Nattokinase 4000 FU - 60 Veg Capsules

Product Overview: High-Potency Systemic Fibrinolytic Support

Think of your circulatory blood vessels like household water pipes that gradually accumulate fibrous debris. Source Naturals Nattokinase 4,000 FU functions like an organic precision drain sweeper, dissolving excess protein mesh to keep blood flowing freely. This formula delivers a clinically validated 200 mg dose of NSK-SD®, the premier patented extract derived from traditional Japanese fermented soy (natto).

By clearing microscopic clutter from your vascular pathways, this systemic enzyme promotes healthy blood viscosity and cardiovascular balance.

• ✓ Active Form & Potency: 4,000 Fibrinolytic Units (FU) from 200 mg of standardized NSK-SD® nattokinase per single capsule.
• ✓ Primary Target: Supports vascular fibrin breakdown (fibrinolysis), optimal blood viscosity, and healthy cardiovascular circulation.
• ✓ Supply & Value: 60 vegetarian capsules per bottle, providing a full 60-day maintenance supply at one high-potency capsule daily.
• ✓ Purity & Dietary Status: 100% vegetarian, non-GMO, Vitamin K2-free, and formulated without gluten, dairy, egg, or synthetic preservatives.

Buyer's Guide: Why NSK-SD® Purity Matters

Why the Form Matters

Standard commodity supplements sold in big-box retail stores frequently use crude, unstandardized natto powders. These discount products rarely declare active Fibrinolytic Units (FU). Without standardized enzymatic activity, stomach acid degrades the active protein before your body absorbs it.

Source Naturals utilizes authentic NSK-SD®, developed by Japan Bio Science Laboratory. This proprietary preparation undergoes a patented isolation process that removes Vitamin K2. Vitamin K2 naturally encourages blood clotting, which works against the circulatory clearing properties of nattokinase. Generic formulas leave Vitamin K2 intact, diluting the cardiovascular benefits you want.

Is This Formula Right for You?

• ✓ Aging Adults: Individuals seeking to support vascular elasticity, smooth arterial flow, and healthy blood pressure within normal ranges.
• ✓ Frequent Travelers & Sedentary Workers: People looking to support microvascular circulation during prolonged sitting or long flights.
• ✓ Targeted Enzyme Users: Shoppers who prefer a potent single-capsule dose of 4,000 FU over swallowing multiple low-dose pills.

• ✗ Anticoagulant Medication Users: Individuals taking prescription blood thinners (like warfarin, heparin, or aspirin) without direct medical supervision.
• ✗ Pre-Surgical Patients: Anyone scheduled for medical or dental surgery within the next 14 days.
• ✗ Severe Soy Allergies: Individuals with diagnosed hypersensitivity to soy-derived fermentation substrates.

Order with complete confidence backed by VitaNet®, LLC's 31-year reputation and unconditional 100% money-back guarantee, allowing you to test digestive tolerance risk-free even on opened bottles[cite: 1, 32].

How It Works in the Body

Picture a tangled spiderweb that snags floating debris in a slow-moving river. In your bloodstream, a fibrous protein mesh (fibrin) captures cellular components to form clots. When circulation slows, excess fibrin makes blood thicker and harder to pump.

Nattokinase functions as a specialized protein-cutting enzyme (serine protease). Once absorbed into your circulation, it works through a distinct two-step pathway:

• 1. Direct Fibrin Breakdown: Nattokinase directly cuts the structural bonds of excess fibrin mesh, breaking it down into harmless microscopic fragments [1].
• 2. Natural Clot-Clearing Activation: It stimulates your body's built-in defense enzyme (plasmin) by boosting tissue plasminogen activator (tPA) while suppressing plasminogen activator inhibitor-1 (PAI-1) [1, 3].

By supporting natural fibrin turnover, nattokinase reduces circulating clotting markers like fibrinogen and factor VII [3]. This action eases vascular resistance, helping maintain healthy blood pressure and smooth blood flow through narrow capillaries [2, 4].

Daily Timing, Synergy & Realistic Timelines

Best Time to Take

Take nattokinase on an empty stomach with a full 8-ounce glass of water. If taken with meals, the enzyme acts like a digestive aid, breaking down food protein instead of entering your bloodstream. Consume it at least 30 to 60 minutes before eating, or 2 hours afterward.

Daily Schedule

Take your capsule at night before bed. Cardiovascular events and natural fibrin accumulation peak during the early morning hours. Taking nattokinase at bedtime provides peak enzymatic support while you sleep.

Smart Pairings & Spacing

Pair nattokinase with Coenzyme Q10 (CoQ10) or pure omega-3 fish oil for enhanced cellular energy and endothelial wellness. Keep a 2-hour separation window away from dietary fiber supplements or activated charcoal, which can trap and deactivate active enzymes.

What to Expect Over Time

• ✓ Days 1–7: The systemic enzyme enters the bloodstream within 2 to 4 hours of ingestion, initiating initial cellular uptake and baseline fibrin turnover [1].
• ✓ Weeks 3–4: Continuous enzymatic activity stabilizes circulating fibrinogen levels, supporting smoother vascular microcirculation and peripheral warmth [3].
• ✓ Months 2–3+: Long-term arterial support establishes steady maintenance for healthy blood pressure and vascular flexibility [2, 4].

Physical Feel, Sensory Traits & Clean Ingredients

Pill Format & Ease of Use

Each serving is packed in a compact Size '0' clear vegetable capsule that swallows smoothly with water. We advise against opening the capsule into liquid; swallowing it intact shields the enzyme from gastric breakdown.

Natural Aroma, Taste & Color

Traditional fermented natto has an overpowering ammonia aroma. In contrast, patented NSK-SD® undergoes gentle purification to remove harsh odors, leaving a subtle, neutral grain scent. The encapsulated powder has a natural off-white to light cream tone without artificial bleaching agents.

Other Ingredients Explained

• Microcrystalline Cellulose: Plant-derived purified wood pulp used as a safe, inert filling agent to ensure uniform enzyme distribution.
• Hydroxypropyl Cellulose (Capsule): 100% plant cellulose shell that dissolves rapidly in the digestive tract without animal gelatin.
• Magnesium Stearate: Vegetable-derived salt that acts as a flow agent to prevent powders from sticking to clean encapsulation machinery.
• Silica: A natural earth mineral that absorbs ambient moisture to prevent clumping and preserve enzymatic activity.

Proper Storage

Store tightly capped in a cool, dry pantry away from direct sunlight, steam, and excessive heat. Do not store in humid bathroom medicine cabinets.

Manufacturer Quality & Lab Testing Standards

Source Naturals enforces strict quality control across every production lot in their in-house analytical laboratories. Their technicians utilize advanced scientific instrumentation to verify the purity and identity of every raw material:

• ✓ Heavy Metal Screening via ICP-MS: Inductively Coupled Plasma Mass Spectrometry measures heavy metals—lead, cadmium, arsenic, and mercury—down to parts-per-billion (ppb) limits, passing strict California Proposition 65 standards.
• ✓ Potency & Identity Testing via HPLC: High-Performance Liquid Chromatography verifies the chemical identity and active 4,000 FU potency of every capsule batch.
• ✓ Microbiological Pathogen Clearance: Automated testing screens out harmful biological contaminants, confirming the total absence of Escherichia coli, Salmonella species, yeasts, and molds.

These rigorous internal laboratory controls protect you from unlisted chemical fillers, microbial contamination, and sub-potent raw materials common among cut-rate online brands.

Complete Supplement Facts Panel

† Daily Value not established.
FU (Fibrinolytic Units) is a measure of active enzyme potency.

Other Ingredients: Microcrystalline cellulose, hydroxypropyl cellulose (capsule), magnesium stearate, and silica.

Allergen Warning: Contains soy. Formulated with Vitamin K2-free NSK-SD®. Contains no yeast, dairy, egg, gluten, wheat, sugar, preservatives, or artificial color, flavor, or fragrance.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Scientific References & Clinical Studies

1. Kurosawa Y, Nirengi S, Homma T, et al. "A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles." Scientific Reports, 2015;5:11601. PMID: 26109079.
2. Jensen GS, Lenninger M, Ero MP, Benson KF. "Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial." Integrated Blood Pressure Control, 2016;9:95-104. PMID: 27785095.
3. Hsia CH, Shen MC, Lin JS, et al. "Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects." Nutrition Research, 2009;29(3):190-196. PMID: 19358933.
4. Kim JY, Gum SN, Paik JK, et al. "Effects of nattokinase on blood pressure: a randomized, controlled trial." Hypertension Research, 2008;31(8):1583-1588. PMID: 18971533.

Frequently Asked Questions

Why must I take nattokinase on an empty stomach instead of with meals?

Nattokinase is a systemic protein-digesting enzyme. If consumed with food, the enzyme acts as a digestive aid, breaking down proteins in your meal. Taking it on an empty stomach allows the enzyme to pass intact into the bloodstream to break down vascular fibrin.