Gugulipid: Controlling cholesterol levels

Darrell Miller

07/27/05

Date: July 27, 2005 03:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Gugulipid: Controlling cholesterol levels

Gugulipid: Controlling cholesterol levels

An ancient Indian plant contains a compound that can help reduce cholesterol as effectively as drugs, but without side effects.

By Michael T. Murray, N.D.

An ancient medicinal plant from India shows promise in the fight against heart disease. The mukul myrrh tree (Commiphora mukul) secretes a resinous material called gum guggul. The classic ayurvedic medical text, the “Suchruttasamhita,” describes guggul’s role in the treatment of obesity and other lipid (fat) disorders.

Comprehensive scientific studies have investigated the clinical effectiveness of gum guggul in disorders of lipid (fat) metabolism. Specifically, researchers have studies this extract’s ability to support healthy cholesterol and triglyceride levels and promote weight loss. As a result of this research, scientists have developed a natural substance-gugulipid-that appears to be safer than many other cholesterol-lowering agents, including niacin.

What is gugulipid?

Gugulipid is the purified standardized extract of crude gum guggul (oleoresin). The active components of gugulipid are Z-guggulsterone and E-guggulsterone. Other components of gugulipid include various diterpenes, sterols, steroids, esters, and fatty alcohols.

Gugulipid is preferred to crude gum guggul because it is safer and more effective. In early studies, gum guggul was linked with mild side effects such as skin rashes, gastrointestinal irritation and diarrhea. In contrast, no side effects have been reported with gugulipid. Apparently, the insoluble irritants of gum guggul are removed in the production of the soluble gugulipid.

This just one example of how science is advancing in the efficacy of herbal therapy. Through careful scientific study, researchers developed a safer and superior form of natural plant medicine.

Pharmacology

Numerous scientific studies have shown gugulipid effectively supports healthy levels of cholesterol and triglycerides. Gugulipid supports low levels of LDL (“bad”) cholesterol and high levels of HDL (“good”) cholesterol. HDL cholesterol has been shown to protect against heart disease caused by atherosclerosis or hardening of the arteries. Research indicated gugulipid itself appears to help reduce atherosclerotic plaques.

Gugulipid has been shown to improve the heart’s metabolism and act as an antioxidant, protecting the heart against free radicals. Gugulipid appears to help inhibit platelet aggregation (clumping of red blood cells), an important factor in preventing stroke or embolism.

According to research findings, gugulipid promotes the liver’s uptake of LDL cholesterol from the blood, thus increasing the liver’s metabolism of LDL cholesterol. This function accounts for gugulipid’s ability to support healthy cholesterol levels.

Because of gugulipid’s effects on heart function and cholesterol, this natural compound appears to be especially useful for individuals with cardiovascular disease. In addition, guggulsterone appears to stimulate thyroid function. This steroid stimulating effect may account for some of gugulipid’s impact on lipid levels and weight loss.

Clinical studies

Gugulipid’s impact on cholesterol and triglycerides is quite startling. When the diet is supplemented with gugulipid, cholesterol levels typically drop 14 to 27 percent in four to twelve weeks, while triglyceride levels drop 22 to 30 percent. Those are extremely significant reductions.

The effect of gugulipid on serum cholesterol and triglycerides compares favorably to that of lipid-lowering drugs. Clofibrate and cholestyramine lower cholesterol levels from six to 12 percent and 20 to 27 percent respectively, but are associated with some degree of toxicity. In contrast, no side effects have been reported with gugulipid. IN addition to the excellent safety demonstrated in human studies, gugulipid has been shown to be nontoxic in safety studies on laboratory animals.

Dosage

Appropriate dosage of gugulipid depends on its guggulsterone content. Clinical studies indicate that 500 mg of gugulipid with a guggulsterone content of 25 mg taken three times per day effectively supports healthy cholesterol and triglyceride levels.

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