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Folic acid enhances Chemotherapy

old message Folic acid enhances Chemotherapy Darrell Miller 10/10/05


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Date: October 10, 2005 12:05 PM
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Subject: Folic acid enhances Chemotherapy

Folic acid enhances Chemotherapy

Scientists have discovered that cancer cells have a natural attraction to folic acid. This safe constituent of vitamin B is now being used as a nontoxic “Trojan horse” to carry chemotherapy directly to various cancers. Researchers reported at the 4th annual Gene, Drug Therapy and Molecular Biology meeting that the vitamin can be used with conventional chemotherapy drugs and a variety of new gene therapies to destroy cancer cells.

Scientists have repeatedly found that folic acid is overexpressed in certain cancers: specifically, cancers of the ovary, cervix, endometrium, kidney, breast, brain, lung and colon. Scientists found that folic acid is especially overexpressed on tumors that are resistant to conventional chemotherapy. Dr. Philip Low of Purdue University and chief scientific officer at Endocyte, Inc. based in Lafayette, Indiana, told attendees that folic acid could become a perfect carrier for many types of tumor targeting. Endocyte researchers estimate that cancers that overexpress the folate receptor are diagnosed in about 300,000 people each year in the US.

This new specific targeting approach exploits cancer cells' insatiable appetite for folic acid. Compared to healthy cells, researchers say that cancer cells have 500,000 times greater affinity for folic acid. The folic acid that these cells ravenously seek can be used to target and deliver drugs to easy-to-find and hard-toreach cancer cells at the same time while avoiding normal, healthy cells. Folic acid does not trigger an immune response in the human body. It is readily available, easy to produce on large scale, and can be attached to a great number of drugs.



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