Immune Renew Fact Sheet
|Immune Renew Fact Sheet||Darrell Miller||12/07/05|
December 07, 2005 01:07 PM
Author: Darrell Miller (firstname.lastname@example.org)
Subject: Immune Renew Fact Sheet
Immune Renew Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05
LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans
KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg)
MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth.
ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels
SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach.
COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect.
This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995
2. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999;19(1):65-96.
3. Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002 Nov;60(3):258-74. Epub 2002 Sep 10.
4. Nanba H, Hamaguchi AM, Kuroda H. The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 1987;35:1162–8.
5. Yamada Y, Nanba H, Kuroda H. Antitumor effect of orally administered extracts from fruit body of Grifola frondosa (maitake). Chemotherapy 1990;38:790–6.
6. Nanba H. Immunostimulant activity in vivo and anti-HIV activity in vitro of 3 branched b-1–6-glucans extracted from maitake mushrooms (Grifola frondosa). VIII International Conference on AIDS, Amsterdam, 1992 [abstract].
7. Kubo K, Nanba H. Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I. Biol Pharm Bull 1997;20:781–5.
8. Adachi K, Nanba H, Otsuka M, Kuroda H. Blood pressure lowering activity present in the fruit body of Grifola frondosa (maitake). Chem Pharm Bull 1988;36:1000–6.
9. Jones K. Shiitake: A major medicinal mushroom. Alt Compl Ther 1998;4:53–9 [review].
10. Taguchi I. Clinical efficacy of lentinan on patients with stomach cancer: End point results of a four-year follow-up survey. Cancer Detect Prevent Suppl 1987;1:333–49.
11. Matsuoka H, Seo Y, Wakasugi H, et al. Lentinan potentiates immunity and prolongs survival time of some patients. Anticancer Res 1997;17:2751–6.
12. Guangwen Y, Jianbin Y, Dongqin L, et al. Immunomodulatory and therapeutic effects of lentinan in treating condyloma acuminata. CJIM 1999;5:190–2.
13. Jones K. Reishi mushroom: Ancient medicine in modern times. Alt Compl Ther 1998;4:256–66 [review].
14. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531–3.
15. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.
16. Suzuki H, et al. Immunopotentiating Substances in Lentinus edodes Mycelial Extract(LEM)-- Activation of Macrophage and Proliferation of Bone Marrow Cell. Nippon Shokakibyo Gakkai Zasshi. Jul1988;85(7): 1430.
17. Suzuki H, et al. Inhibition of the Infectivity and Cytopathic Effect of Human Immunodeficiency Virus by Water-soluble Lignin in an Extract of the Culture Medium of Lentinus edodes Mycelia (LEM). Biochem Biophys Res Commun. Apr1989;160(1):367-73.
18. Gordon M, et al. A Placebo-controlled Trial of the Immune Modulator, Lentinan, In HIV-positive Patients: A Phase I/II Trial. J Med. 1998;29(5-6):305-30.
19. Li JF, et al. Study on the Enhancing Effect of Polyporus Polysaccharide, Mycobacterium Polysaccharide and Lentinan on Lymphokine-activated Killer Cell Activity in vitro. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. Apr1996;16(4):224-26.
20. Li KR, et al. Anti-atherosclerotic Properties of Higher Mushrooms (a Clinico-experimental Investigation. Vopr Pitan. Jan1989;1:16-19.
21. Shouji N, et al. Anticaries Effect of a Component From Shiitake (An Edible Mushroom). Caries Res. Feb2000;34(1):94-98.
22. Levy AM. Eosinophilia and Gastrointestinal Symptoms After Ingestion of Shiitake Mushrooms. J Allergy Clin Immunol. May1998;101(5):613-20.
23. Zjawiony JK. Biologically active compounds from Aphyllophorales (polypore) fungi. J Nat Prod. 2004 Feb;67(2):300-10.
24. Oliva D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev Med Chem. 2004 Oct;4(8):873-9.
25. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
26. Borchers AT, Stern JS, Hackman RM, Keen CL, Gershwin ME. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med. 1999 Sep;221(4):281-93.
27. Mau JL, Lin HC, Chen CC. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002 Oct 9;50(21):6072-7.
28. Hirasawa M, Shouji N, Neta T, Fukushima K, Takada K. Three kinds of antibacterial substances from Lentinus edodes (Berk.) Sing. (Shiitake, an edible mushroom). Int J Antimicrob Agents. 1999 Feb;11(2):151-7.
29. Rajewska J, Balasinska B. Biologically active compounds of edible mushrooms and their beneficial impact on health. Postepy Hig Med Dosw (Online). 2004 Oct 5;58:352-7.
30. Chang R. Functional properties of edible mushrooms. Nutr Rev. 1996 Nov;54(11 Pt 2):S91-3.
31. Lin ZB, Zhang HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004 Nov;25(11):1387-95. PMID: 15525457
32. Cheung NK, Modak S, Vickers A, Knuckles B. Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies. Cancer Immunol Immunother. 2002 Nov;51(10):557-64. Epub 2002 Sep 20. PMID: 12384807
33. Shamtsyan M, Konusova V, Maksimova Y, Goloshchev A, Panchenko A, Simbirtsev A, Petrishchev N, Denisova N. Immunomodulating and anti-tumor action of extracts of several mushrooms. J Biotechnol. 2004 Sep 30;113(1-3):77-83. PMID: 15380649
34. Zhang YD, Shen JP, Zhu SH, Huang DK, Ding Y, Zhang XL. Effects of astragalus (ASI, SK) on experimental liver injury Yao Xue Xue Bao. 1992;27(6):401-6. Chinese. PMID: 1442065
35. Sheng BW, Chen XF, Zhao J, He DL, Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chin Med J (Engl). 2005 Jan;118(1):43-9. PMID: 15642225
36. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005 Jan 4;96(1-2):71-7. PMID: 15588652
37. Li C, Cao L, Zeng Q. Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):379-84. PMID: 15587404
38. Wang SH, Wang WJ, Wang XF, Chen W. [Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Oct;24(10):926-8. Chinese. PMID: 15553830
39. Shao BM, Dai H, Xu W, Lin ZB, Gao XM. Immune receptors for polysaccharides from Ganoderma lucidum. Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41. PMID: 15351712
40. Mao SP, Cheng KL, Zhou YF. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. Chinese. PMID: 15015443
41. Guo FC, Williams BA, Kwakkel RP, Li HS, Li XP, Luo JY, Li WK, Verstegen MW. Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poult Sci. 2004 Feb;83(2):175-82.