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	Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?	Darrell Miller	12/7/23
	six top-notch supplements that can help you achieve your goals.	Darrell Miller	12/6/23
	Your tongue can tell you about your digestive health	Darrell Miller	6/16/17
	Natural Sweeteners Vs. Artificial Sweeteners	Darrell Miller	4/30/09
	Memory And Focus	Darrell Miller	5/8/07
	New Frontiers in Enzyme Supplementation	Darrell Miller	2/16/06
	Folic Acid: Strengthening the Immune System in the Elderly	Darrell Miller	1/9/06
	History	Darrell Miller	6/24/05
	Recognizing the Signs: Roadmap to a Healthy Heart	Darrell Miller	6/13/05
	Basics of the Immune System	Darrell Miller	6/10/05
	COLLOIDALIFE Trace Minerals - The Precious Elements of Life...	Darrell Miller	6/1/05

Date: December 07, 2023 12:12 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?

Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body.

While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption.

GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age.

The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels.

In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body.

This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form.

But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them.

So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing!

Liver Health

When it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ.

Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds.

During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances?

But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker!

The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning.

So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being!

Alcohol Intoxication

Alcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells.

To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes.

The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group.

The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver.

Nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels.

ReCognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy.

In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management.

Beautiful Skin

By activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions.

Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores.

Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects.

Skin Lightening

Skin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract.

The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women.

In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH.

Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin.

The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities.

In summary, the administration of glutathione, whether oral, buccal, or topical, has shown promising results in skin lightening and the improvement of complexion. Studies have demonstrated that glutathione not only enhances skin brightness but also reduces hyperpigmentation, wrinkles, and minimizes pores. Moreover, its effects have been evident in as little as two weeks, with a sustained impact over longer periods. These benefits were observed across a range of different skin types and ethnicities. However, it is important to highlight that these findings are based on specific populations, and more research needs to be conducted to confirm the consistency of these effects across a broader spectrum of skin types and ethnicities. The studies have also confirmed that the usage of glutathione is well-tolerated with no serious adverse effects reported.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6592)

Date: December 06, 2023 04:55 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: six top-notch supplements that can help you achieve your goals.

If you're looking to stay in the game longer and improve endurance while promoting rapid recovery, we've got you covered! six top-notch supplements that can help you achieve your goals.

For most of us, life can feel like quite the balancing act. In an ideal world, we would all have ample time throughout the day to dedicate to our health and well-being. However, reality paints a different picture, where 24 hours can seem like an insufficient amount of time to squeeze in work, school, family, and the countless responsibilities that life throws at us. In recent years, the use of supplements for recovery has gained popularity, becoming more common than ever before.

Our bodies face a barrage of daily stresses, including exposure to environmental toxins, electromagnetic pollution, and the strain of intense physical activity. These factors increase our body's demands for antioxidants and essential nutrients that aid in the process of recovery. While consuming antioxidant-rich foods can certainly make a difference, it can be challenging to meet these requirements solely through our diet. That's where a well-rounded supplement regimen can play a crucial role in promoting optimal health and aiding in recovery. Even with our best efforts to exercise regularly, eat nutritious meals, and get sufficient sleep, life in the 21st century can be incredibly demanding, depleting our bodies on a cellular level.

For athletes, consistent training is key to reaching desired performance levels. It's important to understand that the muscle recovery and building process primarily occurs between gym sessions. Developing a comprehensive recovery strategy during this crucial window, through the use of supplements, proper nutrition, and adequate rest, can help athletes perform at their best week in and week out. Failing to make the most of this recovery period may result in free radical damage and delayed onset muscle soreness (DOMS). To maximize the benefits, it's important to prioritize food as the primary source of vital nutrients, while also reCognizing the significant role supplements can play in providing the necessary building blocks for muscle repair due to their rapid absorption rate. However, it's essential to ensure that any chosen supplements are clinically validated, demonstrating efficacy and supported by solid scientific evidence.

In today's fast-paced world, there is a growing demand for quick and convenient solutions to jumpstart the recovery process. Nevertheless, when it comes to choosing supplements, it's important to remember that one size does not fit all. The market offers an overwhelming array of options, often leaving individuals feeling bewildered about which products to select.

Before diving into my recommendations for the top six supplements to aid in recovery, I believe it's crucial to emphasize the significance of cellular renewal and its direct impact on the recovery process. This, in my opinion, serves as the key to achieving a quick and effective recovery.

Oxidation and Free Radical Damage

A fundamental key to staying young and maintaining optimal health is cellular renewal and minimizing the damage to cells over time. We all age, but studies have shown that some individuals age better than others. Have you ever wondered why? Well, recent research has linked oxidative stress to the aging process. So, what exactly is oxidative stress? Allow me to explain in simple terms – oxidation occurs when the body produces by-products commonly known as free radicals. It's almost like a machine rusting, but instead of rust forming on iron, our bodies experience the effects of aging and age-related diseases.

Now, our bodies naturally produce free radicals as part of our daily metabolism, and they can also be produced as a result of environmental pollutants from everyday things like air, water, and even sun exposure. As we age, our bodies become more vulnerable to the long-term effects of oxidative stress, which simply means we accumulate too many free radicals and experience increased inflammation at the cellular level.

As interesting as it may sound, the process of oxidation is actually abundant and can be beneficial for our bodies to function properly. But, and this is an important "but," this very process can also cause potential harm. You see, the oxidizing process creates these molecules called free radicals, which are electrically charged. These free radicals interact with our cells, and this interaction can lead to both positive and negative outcomes. For example, our immune system utilizes free radicals to help fight infection. However, when LDL cholesterol (often referred to as bad cholesterol) is oxidized, it can become a concern (cholesterol buildup).

Let's talk about oxidative stress. It occurs when the level of free radicals overwhelms the body's natural antioxidant defense system, resulting in cell damage. As I mentioned earlier, while free radicals serve useful functions in the body, they are highly unstable molecules. If they remain uncontrolled, they have the potential to wreak havoc by causing damage to cells, enzymes, and even our DNA, which ultimately accelerates the aging process. In addition, these free radicals can also contribute to the development of various age-related diseases, including arthritis, cancer, and heart disease

Now, inflammation is triggered by free radical damage, and it is this inflammation that leads to the negative effects of free radicals due to oxidation. The question then becomes, how can we address this in our daily nutritional regimen? The answer lies in the incorporation of antioxidants, which play a vital role in combating oxidative stress and minimizing the damage caused by free radicals in our bodies. You'll be glad to know that there are foods rich in antioxidant content that can help us on this journey. In fact, certain foods contain phytonutrients that, according to many health professionals, hold the potential to unlock the secrets of longevity and overall well-being.

So, my dear friend, let's take a proactive approach, nourish our bodies with antioxidant-rich foods, and strive to minimize the effects of oxidative stress caused by free radicals. It's never too late to make positive choices for our health and age gracefully.

Phytonutrients, also known as health boosters, are substances produced by plants to protect themselves from harmful bacteria and viruses. However, these compounds also offer significant benefits to the human body. Packed with essential nutrients, phytonutrients play an active role in promoting good health. They belong to the antioxidant family, responsible for eliminating harmful free radicals and thus slowing down the aging process. Incorporating a diet rich in high antioxidant foods like fresh fruits and vegetables is crucial as the first line of defense against aging.

While vitamins A, C, and E are commonly known antioxidants, there are other antioxidants available in both food and supplement form. These antioxidant supplements play a vital role in bridging the nutritional gap left by processed foods, lacking the necessary antioxidants and nutrients to combat free radicals effectively.

Let's take a closer look at my top six supplement recommendations, known for their efficacy in fighting oxidative stress and promoting optimal recovery:

Beta Alanine: As an amino acid derivative, Beta Alanine is proven to enhance intramuscular carnosine content, improving the body's ability to buffer hydrogen ions. During exercise, the body accumulates hydrogen ions, contributing to fatigue and lowering pH levels. Beta Alanine supplementation can reduce fatigue, enhance exercise performance, and increase training volume. Whether it's interval training or weightlifting to improve running economy, incorporating beta-alanine can have a positive impact on endurance performance and overall training results.

BCAAs: Branched Chain Amino Acids (BCAAs) have become a staple supplement for athletes due to their role in muscle and energy production during exercise. Consisting of three essential amino acids - leucine, isoleucine, and valine - BCAAs have been shown to significantly reduce muscle soreness and expedite the recovery process. Supplementing with BCAAs helps prevent muscle breakdown, as the body does not need to rely on its own muscle tissue for energy. Consequently, protein synthesis remains high, supporting muscle growth and repair.

Creatine, a natural molecule found in muscle cells. When engaging in high-intensity workouts like weightlifting, Creatine helps your body produce adenosine triphosphate (ATP), a vital energy source. This amazing compound improves strength, boosts lean muscle mass, and aids in faster muscle recovery.

Flavonoid Root, a breakthrough extract known for its cardiovascular benefits. This extract is packed with potent antioxidants and acts as a nitric oxide booster, promoting increased endurance during workouts. Studies have shown that it fights against free radical damage and increases the flow of oxygen-rich blood, ensuring optimal cardiovascular health. You can also boost nitric oxide with beet root, and l-citruline.

Speaking of studies, a published research paper in Food and Nutrition Research (April 2016) highlighted the effects of the unique flavonoid root extract on arterial health. The study revealed that after one year of consumption, participants experienced a decrease in artery wall thickness, total cholesterol, LDL levels, and blood pressure. This indicates that the extract may help reduce the risk of oxidation-related cerebral vascular issues and improve overall cardiovascular health

Glutamine. It's the most abundant amino acid in the human body and plays a vital role in muscle recovery and repair. Glutamine aids in preventing muscle soreness, optimizing post-workout recovery, and supporting muscle rebuilding. By facilitating nitrogen transport, regulating acid-base balance, and acting as an antioxidant, Glutamine ensures faster post-workout muscle recovery, giving you the freedom to train harder for better results.

Protein plays a crucial role in replenishing and repairing your muscles after a workout, making it a key nutrient to consume alongside carbohydrates. By opting for a protein shake as a post-workout option, you can efficiently supply amino acids to your muscles, stimulating muscle protein synthesis, enhancing recovery, and promoting growth. It's important, though, to choose a protein shake that contains high-quality ingredients, as prioritizing quality over quantity is key when it comes to protein.

Apart from protein, there are several other supplements that work through various mechanisms to provide natural, broad-spectrum antioxidant and nutrient support, ultimately contributing to optimal health and recovery. Taking preventative measures to protect the health of different body systems is much easier than trying to restore their function after damage has occurred. With this in mind, retailers should suggest a preventive program to their customers, aiming to limit free radical damage and promote recovery. As the adage goes, "an ounce of prevention is worth a pound of cure," emphasizing the significance of protecting and preserving one's health.

In conclusion, the role of antioxidants, particularly phytonutrients, in maintaining overall health and combating oxidative stress cannot be overstated. These beneficial compounds not only slow down the aging process, but also enhance the body's ability to recover from physical exertion. Various supplements, including Beta Alanine, BCAAs, Creatine, Flavonoid Root, Glutamine, and Protein, each offer distinct benefits in supporting muscle growth, improving athletic performance, and promoting quicker recovery. The incorporation of these supplements into one's regimen can effectively bridge the nutritional gap left by processed foods. A preventive strategy, emphasizing a diet rich in antioxidants and high-quality supplements, holds the key to optimal health and longevity. As the saying goes, 'an ounce of prevention is worth a pound of cure'.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6591)

Date: June 16, 2017 09:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Your tongue can tell you about your digestive health

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4842)

Date: April 30, 2009 10:16 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Natural Sweeteners Vs. Artificial Sweeteners

Artificial sweeteners are food additives intended to replace the sweetness of sugar without the calorie intake. There are also natural sweeteners that can replace sugar, so which should you choose? Natural sweeteners such as sugar, honey and grape juice are well known, although there are also the less well known, but much more effective, sucanat and stevia.

Sucanat is dried unrefined cane sugar, and unlike refined sugar retains the molasses. Stevia, on the other hand, is a shrub, native to Paraguay, the leaf of which contains a non-sucrose sweetener, 300 times the sweetness of sugar, and which is not absorbed by the body. It is a sweetener pure and simple, with no proven health issues. It is also Japan's most popular sugar substitute.

Artificial sweeteners have been known for many years, the first and best known being benzoic sulfanide, known to you as saccharin. The health risks of saccharin have been the subject of debate for over 100 years and have yet to be resolved. Studies had shown it to cause cancer in rats, and it was placed on a list of known or suspected carcinogens.

It has been banned for use in the USA, but that was lifted by the FDA in 1991, and in 2000 saccharin has no longer required a health warning label. The issue appears to have been resolved by rats metabolizing saccharin in a way not possible in humans. However, many are still suspicious of it, and if you don't trust a food additive then do not voluntarily consume it.

The top two artificial sweeteners in the USA are sucralose and aspartame. Sucralose, discovered in the UK in 1976, is the less emotive of the two, and is chemically the chlorocarbon trichlorogalactosucrose, produced by chlorination of sucrose and 600 times as sweet. It should be stressed that a chlorocarbon is totally different to a chlorinated hydrocarbon. It is generally considered safe to use, although it is very slow rate of degradation in waste water has raised concerns that concentrations could increase with increasing popularity of the sweetener.

According to' Sweet Deception', the book states sucralose to be discovered during the search for an insecticide, and is produced when sugar is treated with acetic anhydride, hydrogen chloride and trityl chloride among others in the presence of toluene, MIBK and dimethyl formamide among other solvents. Although marketed as coming from a natural source, it is anything but natural.

Aspartame was developed by G.D. Searle, and its approval by the FDA has been a matter of concern for many years. Promoted by Donald Rumsfeld, then CEO of Searle, he "called in his markers" to have the substance approved, which was not one of the more glorious moments in America's history.

It is used in over 6,000 products, most household names, yet was based on "inconclusive and incompetent science" according to detractors. In 1981, on the day of his inauguration, Ronald Regan suspended the powers of the FDA on aspartame, and then a month later appointed a new FDA head, Arthur Hayes, who immediately licensed the substance. Donald Rumsfeld was on President Regan's team.

There is a strong body of evidence that aspartame is toxic to humans, although the official evidence has discredit such studies. Recent evidence that linked aspartame to cancer has been stated as irrelevant to humans. In spite of the concerns, the substance has been approved, not only in the USA but also by the European Union. This might call into question the relevance of studies to humans, but many still believe that commercial considerations are behind these decisions.

In fact, an extensive study carried out by the Italian European Ramazzini Foundation, showed that aspartame can cause a significant increase in cancers and leukemias in rats at well below the doses allowed by the EU or the US. This substance required further study by bodies with no vested interest in the outcome.

Those that believe so point to the stevia situation. This natural sweetener is banned for use as a food additive in the EU, and cannot be sold as sweetener due to the FDA not reCognizing it as such. It has also been banned in Hong Kong, even though it is the sweetener of choice in Japan, with no apparent side-effects becoming endemic in that country. The USA might not approve stevia as a sweetener, but it is considering lifting its ban on cyclamate.

Cyclamate was banned by the FDA due to tests on rats indicating a possibly carcinogenic effect, but no more positive than those on aspartame. Cyclamate is permitted in Canada, where saccharin is not, and also in the UK, but not throughout the EU.

It is obvious, then, looking at the various claims and counter-claims, and the conflicting legislation between civilized countries, that the artificial sweetener industry is wrought with uncertainty. In the past, it is almost certain that commercial considerations have come before the health of the nation, and that does not engender confidence.

In fact, the only sane approach to take at this time would be to avoid artificial sweeteners altogether, and stay natural. That is not to claim that natural products are safe to eat - far from it! Many of the most virulent poisons are natural, but the well-used natural sweeteners appear to be safer at this time than any of those artificially manufactured.

There might be objections to this where diabetes is concerned, and Canada, while banning saccharin for normal use, still allows it for use by diabetics. This is the one of the two major bodies that promotes the use of artificial sweeteners: the diabetic lobby and the weight loss lobby.

It is difficult to question the obesity and weight problem that America has while at the same time arguing against the use of artificial sweeteners. However, don't forget that stevia is widely used in Japan with no reported health problems, and stevia is a natural sweetener that is permitted for use as a food additive, and that is not absorbed by the body.

However, there is also a recent 2005 study that has indicated that diet drinks containing artificial sweeteners might fool your body into believing that the sweet taste is promising energy, and when it doesn't materialize, you feel hungry and eat more. This has been supported by animal studies.

These have shown convincingly that the sensation of sweetness induces the production of insulin with resulting hypoglycemia because there is no actual increase in blood sugar. This induces increased food intake. This has been proved with rats, and also proved was the fact that the natural response of eating less at the next meal, after sugary food, was gradually diminished in animals fed non-calorific sweeteners.

The choice is yours, but it would seem advisable to stick to natural sweeteners for the time being, at least until the studies carried out are in concurrence as opposed to offering conflicting results depending upon who is doing the testing.

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Buy Natural Sweeteners at Vitanet ®, LLC

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Date: May 08, 2007 02:05 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Memory And Focus

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Improve Memory and Focus at Vitanet Vitamin Store

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Date: February 16, 2006 04:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: New Frontiers in Enzyme Supplementation

New Frontiers in Enzyme Supplementation

By Nick Rana, CN, NOW Quality Assurance

Serrazimes® is a proteolytic (protein digesting) enzyme system containing protease that is derived from edible non-genetically engineered fungi (Aspergillus oryzae and Aspergillus melleus), that is designed as an alternative for Serrapeptidase (also known as serratio-peptidase and serrapeptase) in dietary supplements used for cardiovascular, anti-inflammatory, respiratory, or immune support.

Serrapeptidase was initially isolated from Serratia marcescens, a potentially pathogenic bacteria found in the gut of the Japanese silkworm. Recognized as a pharmacological agent, Serrapeptidase has wide clinical use in Asia and Europe for the management of assorted inflammatory processes (Rothschild, 1991). In recent years, recognition of the efficacy of the Japanese product has lead to growing interest in the US dietary supplement market.

The product’s efficacy and availability over the internet has fueled its popularity in the US dietary supplement industry, where it is used for anti-inflammatory support, cardiovascular support, respiratory support, and as an adjunct to antibiotic therapy. ReCognizing the potential for a "Serrapeptidase-type” enzyme in the U.S. dietary supplement market, the National Enzyme Company developed a protease system that has the same in vitro (lab test) activity as Serrapeptidase, but that is from organisms that have a long history of safe use in dietary supplements. Serrazimes® is the product resulting from this search.

Since the 1960’s, plant and microbial protease enzymes have been studied for their role in the management of inflammation and inflammatory processes. In both animal and human trials, proteolytic enzymes, from a variety of sources, have repeatedly been shown to significantly reduce inflammation resulting from sickness or injury (Ryan, 1967)(Smyth et al, 1967)(Shaw, 1969)(Kumakura et al, 1988)(Lomax, 1999). The earlier research on the anti-inflammatory actions of proteases pointed entirely to their antithrombic and fibrinolytic aspects to explain this phenomenon. However, studies by Parmely (Infect and Immun Sept 1990) and others indicate that, in addition to degrading fibrin, microbial proteases may actually inactivate pro-inflammatory cytokines and to interrupt inflammatory responses.

Persons taking blood thinning or antibiotic medications and those with serious health disorders should consult their medical practitioner prior to taking Serrazimes®. As is the case with most supplements, please consult your doctor about the use of Serrazimes® during pregnancy and lactation.

The Product Development Team at NOW Foods is constantly researching new products like Serrazimes® to provide our customers with the tools that empower them to live healthier lives. Look also for our new unique digestive enzyme formulations from plant sources - backed by laboratory studies - to be introduced in March of 2006.

TECHNICAL NOTES:

Serrapeptidase is a selective alkaline metalloprotease enzyme, meaning that it works to activate specific biological systems of mammals and directly degrades or inhibits IgG and IgA immune factors as well as the regulatory proteins á-2-macroglobulin, á-2-antiplasmin, and antithrombin III (Molla et al, 1989)(Maeda and Molla, 1989).

While originally isolated from Serratia marcescens, a bacteria found in the gut of the Japanese silk worm, Serrapeptidase activity is also found in fermentation extracts of Serratia E-15, Aspergillus oryzae, and Aspergillus melleus. (Salamone and Wodzinski, 1997).

The Serrapeptidase activity of this high potency proteolytic (protein digesting) enzyme is determined using a spectrophotometric assay testing procedure that measures the enzyme’s ability to hydrolyze (digest) a standard casein protein substrate. Laboratory analyses have established that Serrazimes® has a 1:1 enzymatic equivalent of Serrapeptidase activity guaranteed to provide 600,000 specialized proteolytic Units per gram, or 20,000 units per capsule.

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Buy Serrapeptase at Vitanet ®

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Date: January 09, 2006 09:38 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Folic Acid: Strengthening the Immune System in the Elderly

Folic Acid: Strengthening the Immune System in the Elderly

By Greg Arnold, DC, CSCS, December 20, 2005, abstracted from “Dietary folate improves age-related decreases in lymphocyte function” in the January 2006 issue of the Journal of Nutritional Biochemistry Recent research has elucidated health-promoting roles for folic acid beyond that of insuring normal development of the fetus. In addition to helping decrease neural tube defects,1 folic acid can also help treat inflammatory bowel disease 2 improve memory 3 and help decrease an amino acid in the body, homocysteine,4 that increases heart disease risk.5 Now a new study 6 has found another way that folic acid can help us age more gracefully: by helping strengthen our immune system. ReCognizing the importance of nutrition in the overall health of the immune system 7 and knowing that certain types of immune system cells, called “T cells”, decrease with age,(8,9) researchers fed 11-month-old and 23-month-old male rats either a control diet or a diet fortified with 35.7 mg per kg of folic acid for three weeks. Researchers found “a significant” increase in immune system strength in the folic acid group, specifically that of increased T cell levels, other immune system proteins called IL-2, IL-4, and anti-cancer proteins called “tumor necrosis factor”. While the study reaffirmed the immune system’s weakening with increasing age, the researchers concluded that “supplementing…with additional folate improves [immune system function] and that dietary folate requirement may be higher in the older population than in the younger population to support immune functions.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:ChiroDocPSUalum@msn.com or visiting his website www.CompleteChiropracticHealthcare.com Reference:
1 “Spina Bifida and Anencephaly Before and After Folic Acid Mandate --- United States, 1995--1996 and 1999—2000” from MMWR Weekly 2004; 53(17): 362-365
2 Danese S. Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease. Am J Gastroenterol. 2005 Apr;100(4):886-95
3 “The First Ever Dementia Conference Opens In Washington, DC” posted on the Alzheimer’s Association Website www.alz.org/preventionconference/pc2005/overview.asp
4 Daly S. Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age. QJM. 2002 Nov;95(11):733-40
5 Stampfer J. Homocysteine levels and cardiovascular disease. Am Fam Physician. 1997 Oct 15;56(6):1568, 1571-2
6 C.J. Field, I.R. Johnson and P.D. Schley, Nutrients and their role in host resistance to infection, J Leukoc Biol 71 (2002), pp. 16–32
7 L. Haynes, S.M. Eaton, E.M. Burns, M. Rincon and S.L. Swain, Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo, J Immunol 172 (2004), pp. 5194–5199
8 R.B. Effros, Replicative senescence of CD8 T cells: effect on human ageing, Exp Gerontol 39 (2004), pp. 517–524

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Date: June 24, 2005 01:13 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: History

HISTORY

Because 20th century medical practices have routinely over - prescribed antibiotics, the notion of a natural antibiotic with virtually no side-effects is intriguing to say the least. Echinacea is one of several herbs which possesses antibacterial, antiviral and antifungal properties. In a time when new life-threatening microbes are evolving and pose the threat of modern-day plagues, herbs such as echinacea are particularly valuable. More and more health practitioners are focusing on fortifying the immune system to fight off potential infections rather than just treating infection after it has developed.

Echinacea is enjoying a renaissance today. During the late 1980’s, echinacea re-emerged as a remarkable medicinal plant. In addition to its infection fighting properties, echinacea is known for its healing properties as well. As was the case with so many herbs, echinacea lost its prestige as a medicinal treatment with the advent of antibiotics. It has experienced a resurgence over the last two decades.

Echinacea has several other much more romantic names including Purple Coneflower, Black Sampson and Red Sunflower. It has also become the common name for a number of echinacea species like E. angustifolia, E. purpurea, and E. pallida. The genus derives its name from the Greek word echinos which refers to sea urchin. This particular association evolved from the prickly spiny scales of the seed head section of the flower. Historically, echinacea has sometimes become confused with Parthenium integrifolium.

The word echinacea is actually apart of the scientific latin term, echinacea angustifolia, which literally translated means a narrow - leafed sucker. The plant grows wild as a perennial exclusively in the midwestern plains states, but can be cultivated almost anywhere . Echinacea leaves are pale to dark green, coarse and pointy. Its florets are purple and its roots, black and long.

Echinacea has a strong Native American link in the Central Plains. Native Americans are credited with discovering the usefulness of this botanical without knowing its specific chemical properties. It was routinely used by Na t i ve Americans to treat toothaches, snakebite, fevers and old stubborn wounds.

Native Americans thought of echinacea as a versatile herb that not only helped to fight infection, but increased the appetite and s t rengthened the sexual organs as well. The juice of the plant was used to bathe burns and was sprinkled on hot coals during traditional “sweats” used for purification purposes. It is also believed that some Native Americans used echinacea juice to protect their hands, feet and mouths from the heat of hot coals and ceremonial fires.1 According to Melvin Gilmore, An American anthropologist who studied Native American medicine in the early part of this century, Echinacea was used as a remedy by Native Americans more than any other plant in the central plains area.

In time, early white settlers learned of its healing powers and used the plant as a home remedy for colds, influenza, tumors, syphillis, hemorrhoids and wounds. Dr. John King, in his medical journal of 1887 mentioned that echinacea had value as a blood purifier and alterative. It was used in various blood tonics and gained the reputation of being good for almost every conceivable malady. It has been called the king of blood purifiers due to its ability to improve lymphatic filtration and drainage. In time, echinacea became popular with 19th century Eclectics, who were followers of a botanic system founded by Dr. Wooster Beech in the 1830’s. They used it as an anesthetic, deodorant, and stimulant.

By 1898, echinacea had become one of the top natural treatments in America. During these years, echinacea was used to treat fevers, malignant carbuncles, ulcerations, pyorrhea, snake bites and dermatitis. In the early twentieth century, echinacea had gained a formidable reputation for treating a long list of infectious disease ranging from the commonplace to the exotic. The Lloyd Brothers Pharmaceutical House developed more sophisticated versions of the herb in order to meet escalating demands for echinacea.

Ironically, it was medical doctors who considered echinacea more valuable than eclectic practitioners. Several articles on echinacea appeared from time to time in various publications. Its attributes we re re v i ewed and, at times, its curative abilities ranged from the sublime to the ridiculous. In 1909, the Council on Pharmacy and Chemistry of the American Medical Association decided against reCognizing echinacea as an official drug, claiming that it lacked scientific credibility. It was added to the National Formulary of the United States despite this type of negative reaction and remained on this list until 1950.

Over the past 50 years, echinacea has earned a formidable reputation achieving worldwide fame for its antiviral, antifungal and antibacterial actions. Consumer interest in echinacea has greatly increased, particularly in relation to its role in treating candida, chronic fatigue syndrome, AIDS and malignancies. Practitioners of natural medicine in Eu rope and America have long valued its attributes. In recent, years, German research has confirmed its ability to augment the human immune system. Extensive research on echinacea has occurred over the last twenty years. Test results have s h own that the herb has an antibiotic, cortisone-like activity.

Echinacea has the ability to boost cell membrane healing, protect collagen, and suppress tumor growth. Because of its immuno-enhancing activity, it has recently been used in AIDS therapy. Research has proven that echinacea may have p rofound value in stimulating immune function and may be particularly beneficial for colds and sore throats.3

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Date: June 13, 2005 10:06 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: ReCognizing the Signs: Roadmap to a Healthy Heart

ReCognizing the Signs: Roadmap to a Healthy Heart by Louis McKinley Energy Times, January 2, 2004

From time immemorial, people have tuned into life's lessons that come from the heart. Sadly, times are changing: If you're like most inhabitants of today's harried world, you may be too distracted to detect important clues about your cardiovascular circumstances.

And while heart lessons may be more complicated than simply connecting the physiological dots, understanding those heart messages are imperative for improving and maintaining your heart health.

Every cell in your body relies on heart-powered blood flow to keep it supplied with nutrients, oxygen, hormones and other natural chemicals necessary for survival. Without that supply of life-giving substances, few cells in the body-including those within the heart itself-can survive very long.

And just as damage to a major roadway can cause mayhem with traffic patterns, damage to blood vessels and the heart can wreak a lumpy cardiovascular havoc that blocks the passage of blood and endangers your heart's well-being.

Your Heart Disease Chances

Within the last ten years, scientific research performed by investigators around the world has focused on the specific factors that most strongly influence your chances of developing heart disease and suffering either a heart attack or a stroke.

While much of your risk depends on your genetic inheritance and family history, several factors that determine your heart health are within your control.

The most important factors you can do something about include:

* Smoking: free radicals generated by burning tobacco causes significant damage to blood vessels and other cells

* Lack of exercise: the human body is designed for consistent, moderate physical activity; without exercise, the body slacks off in creating antioxidant protection for arteries

* Diabetes: when excess blood sugar persists, physiological processes begin that endanger the heart and arteries

* Cholesterol: when oxidized (a chemical process that has been compared to a kind of internal rusting), cholesterol can form artery-blocking plaque; antioxidant nutrients like vitamin C and natural vitamin E may help the body limit this process

* High blood pressure: excessive pressure within the blood vessels raises the risk of damage to the heart and arteries; a program of weight loss and exercise can help control blood pressure

* Being overweight: the extra body fat carried around your middle is linked to a greater risk of heart problems

Heart Attack Signs

Do you think you know what a heart attack feels like? Well, if you think it feels like a dramatic pain somewhere in your chest that knocks you to the floor, you're probably wrong. "Most heart attacks do not look at all like what one of my colleagues calls the 'Hollywood' attack-the heart attack you see on television or in the movies," warns Julie Zerwic, MD, professor of surgical nursing who has studied what happens when people develop heart disease and suffer damage to their hearts.

"The symptoms [of heart problems] are not necessarily dramatic. People don't fall down on the floor. They don't always experience a knife-like, very sharp pain. In fact, many people describe the sensation as heaviness and tightness in the chest rather than pain," she says. And, if you're a woman experiencing a heart attack, you may not even feel discomfort specifically in your chest. Instead you may experience a severe shortness of breath. The apparent ambiguity of the discomforts caused by a heart attack lead many people to either ignore them or take hours to realize they need to go to the emergency room at the hospital.

Consequently, much fewer than half of all individuals undergoing a heart attack actually go to a hospital within an hour of the start of the attack. That delay can be a fatal mistake.

"Timing is absolutely critical," laments Dr. Zerwic. "If treatment starts within a hour after the onset of symptoms, drugs that reestablish blood flow through the blocked coronary artery can reduce mortality by as much as 50%. That number drops to 23% if treatment begins three hours later. The goal is to introduce therapy within two hours."

However, in Dr. Zerwic's research, only 35% of non-Hispanic whites go to the hospital within an hour of the start of a heart attack. And among African-Americans, the number of people going to the hospital right away drops to a frighteningly low 13%.

Often, people will lie down or use a heating pad to relieve the tightness they feel in the chest," says Dr. Zerwic. "They may take some medicine and wait to see if that works. All these steps postpone needed treatment."

Signs of a possible heart attack include:

* Chest discomfort: Heart attacks most frequently cause discomfort in the center of the chest that can either go away after a couple of minutes (and come back) or persist. The discomfort may feel like strong pressure, fullness or pain.

* Upper body discomfort: An attack may set off pain or discomfort in either or both arms, and/or the back, neck, jaw or stomach.

* Shortness of breath: Chest discomfort is frequently accompanied by shortness of breath. But it's important to note that shortness of breath can take place even in the absence of chest discomfort.

* Other signs: You can also break out in a cold sweat, or feel nauseated or light-headed.

A Woman's Sleep Signs

If you are a woman who suddenly experiences a marked increase in insomnia and puzzling, intense fatigue, you may be in danger of an imminent heart attack.

In an attempt to understand how women's symptoms of heart problems differ from those of men, researchers talked to more than 500 women in Arkansas, North Carolina and Ohio who had suffered heart attacks. (Technically, what they had experienced is referred to as acute myocardial infarction.)

They found that chest pain prior to a heart attack was only reported by about 30% of the women surveyed.

More common were unusual fatigue, sleep disturbances and shortness of breath (Circulation Rapid Access, 11/3/01).

"Since women reported experiencing early warning signs more than a month prior to the heart attack, this [fatigue and sleep problems] could allow time to treat these symptoms and to possibly delay or prevent the heart attack," says researcher Jean C. McSweeney, PhD, RN, nursing professor at the University of Arkansas for Medical Sciences in Little Rock. In Dr. McSweeney's study, more than nine out of ten women who had heart attacks reported that they had had new, disturbing physical problems more than a month before they had infarctions.

Almost three in four suffered from unusual fatigue, about half had sleep disturbances, while two in five found themselves short of breath.

Other common signs included indigestion and anxiety.

"Women need to be educated that the appearance of new symptoms may be associated with heart disease and that they need to seek medical care to determine the cause of the symptoms, especially if they have known cardiovascular risks such as smoking, high blood pressure, high cholesterol, diabetes, overweight or a family history of heart diseases," says Dr. McSweeney.

Dr. McSweeney warns that, until now, little has been known about signs that women are having heart trouble or heart attacks. The fact that most of Western medicine's past attention has been on heart problems in men has obscured the warning signs in women. As part of Dr. McSweeney's studies, she and her fellow researchers have discovered that more than 40% of all women who suffer a heart attack never feel any chest discomfort before or during the attack.

"Lack of significant chest pain may be a major reason why women have more unrecognized heart attacks than men or are mistakenly diagnosed and discharged from emergency departments," she notes. "Many clinicians still consider chest pain as the primary symptom of a heart attack."

Vitamins for Diabetes and Heart Disease

Having diabetes significantly raises your chance of heart disease, which means that keeping your blood sugar levels under control can reduce your chances of suffering a heart attack.

Today, 17 million Americans have diabetes and, as the country's population in general gains weight and fails to exercise, the number of people suffering this problem continues to grow.

The first line of defense against diabetes consists of exercise and weight control. All you have to do is take a brisk walk for 30 minutes a day to drop your chances of diabetes (American Journal of Epidemiology 10/1/03).

"We have found that men and women who incorporate activity into their lifestyles are less likely to develop type 2 diabetes than those who are sedentary. This finding holds no matter what their initial weight," said Andrea Kriska, PhD, professor of epidemiology at University of Pittsburgh Graduate School of Public Health.

To help your body fight the development of diabetes, researchers also recommend vitamin C and natural vitamin E.

Researchers working with lab animals at the University of California at Irvine have found that these antioxidant vitamins can help insulin (the hormone-like substance secreted by the pancreas) reduce harmful blood sugar. In addition, these vitamins shrink the chances of organ damage that can be caused by diabetes (Kidney International 1/03).

In this investigation, these vitamins also helped reduce blood pressure, another risk factor that raises heart disease risk.

"Blood pressure was lowered to normal, and free radicals were not in sufficient numbers to degrade the sugars, proteins and nitric oxide," notes Nick Vaziri, MD, professor of medicine at the University of California. "We think this shows that a diet rich in antioxidants may help diabetics prevent the devastating cardiovascular, kidney, neurological and other damage that are common complications of diabetes."

Free Radical Blues

Dr. Vaziri and his group of researchers found that untreated diabetes raised blood pressure and increased the production of free radicals, caustic molecules that can damage arteries and the heart. Free radicals can change blood sugar and other proteins into harmful substances, boosting tissue and heart destruction.

In Dr. Vaziri's work with lab animals, he found that treating diabetes with insulin lowered blood pressure and helped keep sugar and protein from changing into dangerous chemicals, but allowed the free radicals to subvert nitric oxide, a chemical the body uses to protect itself from free radicals.

In this investigation, adding vitamins C and E to insulin insulated the body's sugars, proteins and nitric oxide from oxidative assault. This produces a double advantage: Lowering the risk of heart disease and other damage to the body from diabetes.

Maitake, an Oriental mushroom that has been shown to have many health benefits, can also be useful for people with diabetes who are trying to avoid cardiovascular complications. Laboratory studies in Japan demonstrate that maitake may help lower blood pressure while reducing cholesterol (Biological & Pharmaceutical Bulletin 1997; 20(7):781-5). In producing these effects, the mushroom may also help the body reduce blood sugar levels and decrease the risk of tissue damage.

No Smoking!

Tobacco smoke is one of the most notorious causes of heart problems. In the same way a hard frost exerts a death grip on a highway, the smoke from cigarettes can freeze up arteries and hamper their proper function. A healthy artery must stay flexible to comfortably allow adequate circulation.

But "...when blood vessels are exposed to cigarette smoke it causes the vessels to behave like a rigid pipe rather than a flexible tube, thus the vessels can't dilate in response to increased blood flow," says David J. Bouchier-Hayes, MD, professor of surgery at the Royal College of Surgeons in Ireland, who has studied the deleterious effects of tobacco.

This rigidity is called endothelial dysfunction. When arteries are rigid, blockages gum up vessels, clots and other impediments to blood flow appear, and your risk of heart attack and stroke increases (Circulation 2001 Nov 27; 104(22):2673).

This condition can also cause chest pain (angina) similar to that caused by a heart attack, and should be evaluated by a knowledgeable health practitioner.

Although all experts recommend you stop smoking to lower your heart disease risk, some studies have found that Pycnogenol(r), a pine bark extract that helps the body fight inflammation, may ease some of smoking's ill effects.

In a study of platelets, special cells in the blood that can form dangerous blood clots, researchers found that Pycnogenol(r) discouraged platelets from sticking together (American Society for Biochemical and Molecular Biology 5/19/98). By keeping platelets flowing freely, this supplement may alleviate some of the heart-threatening clots that tobacco smoke can cause.

In Ayurvedic medicine, a traditional therapy from India, an herb called guggul has also been used to lower the risk of blockages in arteries. This herb, derived from the resin of the mukul tree, has been shown to reduce cholesterol by about 25%. People taking this herb have also reduced their triglycerides (harmful blood fats) by the same amount (Journal Postgraduate Medicine 1991 37(3):132).

The Female Version of Heart Disease

For one thing, women often don't suffer from the crushing chest pain that for most people characterizes a heart attack; instead, many women experience back pain, sweating, extreme fatigue, lightheadedness, anxiety or indigestion, signs that can be easily misread as digestive troubles, menopausal symptoms or indicators of aging.

The genders also differ in how heart disease poses a threat. While men seem most endangered by the buildup of blockages in arteries, women apparently are more at risk from endothelial dysfunction. But more study needs to be done since, in many cases, researchers have been unable to pin down the precise mechanism that causes many women to die of heart disease.

Scientists have found that the number of women in their 30s and 40s who are dying from sudden cardiac arrest is growing much faster than the number of men of the same age who die of this cause. But research by the Oregon Health & Sciences University and Jesse E. Edwards Cardiovascular Registry in St. Paul, Minnesota, shows that while doctors can pinpoint the coronary blockages that kill men, they can't find specific blockages in half of the female fatalities they have studied (American Heart Journal 10/03).

"This was an unexpected finding. However, the study underscores the need to focus on what is causing these younger women to die unexpectedly because the number of deaths continues to increase," says Sumeet Chugh, MD, a medical professor at Oregon.

Since the failure of arteries to relax probably contributes to heart disease in many women, eating red berries, or consuming supplements from berries such as chokeberry, bilberry or elderberry, may be important in lowering women's heart disease risk. These fruits help arteries expand and allow blood to flow freely.

Red berries are rich sources of flavonoids, polyphenols and anthocynanins. The anthocyanins are strong antioxidants that give the berries their color. Research at the Indiana University School of Medicine have found that these chemicals can interact with nitrous oxide, a chemical produced by the body, to relax blood vessels (Experimental Biology conference 5/20/02).

Working Out

As researchers work to devise lifestyle roadmaps that can steer you around the perils of heart disease, they are finding that exercise is a key path to avoiding cardiovascular complications.

A 17-year study of about 10,000 Americans found that those who exercised and kept their weight down (or took weight off and kept it off) experienced a significantly lower risk of heart problems (Preventive Medicine 11/03).

"The fact is that those who both exercised more and ate more nevertheless had low cardiovascular mortality," says Jing Fang, MD, of the Albert Einstein College of Medicine in the Bronx, New York. Burning calories in physical activity may be the secret to reducing heart disease risk and living longer, she says.

Dr. Fang's research used information collected from the First National Health and Nutrition Examination Survey in 1975 and then computed how much people exercised, how their body mass indices varied and which of these folks died of heart disease during the next two decades.

In the study, more than 1,500 people died of heart disease. Those who worked out and consumed more calories cut their risk of heart disease death in half.

Exercise Is Essential

"Subjects with the lowest caloric intake, least physical activity, and who were overweight or obese had significantly higher cardiovascular mortality rates than those with high caloric intake, most physical activity, and normal weight," Dr. Fang notes. The individuals in the study who were overweight and didn't exercise had a bigger risk of heart disease even if they tried (and succeeded) at eating less.

"This suggests that heart disease outcome was not determined by a single factor, but rather by a compound of behavioral, socioeconomic, genetic and clinical characteristics," according to Dr. Fang.

According to researchers, if your job requires a great deal of physical activity, your health will be better if you get another job. Exercise on the job not only doesn't decrease your risk of heart disease, it may actually raise it. The reason: On-the-job activity is linked to heart-endangering increases in job stress.

Research into this subject, performed at the Keck School of Medicine of the University of Southern California, found that while recreational exercise slowed hardening of the arteries, workers who had to exert themselves during the workday had arteries that were blocked at a younger age (American Journal of Medicine 7/03).

In this study, researchers examined about 500 middle-aged employees as part of what is called the Los Angeles Atherosclerosis Study.

"We found that atherosclerosis progressed significantly faster in people with greater stress, and people who were under more stress also were the ones who exercised more in their jobs," says James Dwyer, PhD, professor of preventive medicine at the Keck School. According to Dr. Dwyer, "This suggests that the apparent harmful effect of physical activity at work on atherosclerosis-and heart disease risk-may be due to the tendency of high-activity jobs to be more stressful in modern workplaces.

"It appears from our findings that the psychological stresses associated with physically active jobs overcomes any biological benefit of the activity itself."

Playful Workouts

On the other hand, the scientists found that heart disease drops dramatically among those who exercise the most in their spare time. In the study, people who vigorously worked out at least three times a week had the lowest risk. But even those who just took walks enjoyed better heart health than people whose most strenuous activity was working the TV remote. Dr. Dwyer says, "These results are important because they demonstrate the very substantial and almost immediate-within one or two years-cardiovascular benefit of greater physical activity."

Lowering your risk of heart disease is substantially up to you. Listen to what your heart tells you it needs; then, exercise your right to fetch some cardiovascular necessities.

--
Vitanet ®

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Date: June 10, 2005 03:01 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Basics of the Immune System

Basics of the Immune System

by Leonid G. Ber, MD Energy Times, September 1, 1998

In a world filled with pathogens and microbes, good health and resistance to disease is no accident. It requires a vigorous and vigilant immune system. The immune system should be viewed as an internal security force that is constantly checking the identity of everything entering and already existing in the body. A cell or substance may be recognized as "non-self" and a potential enemy if it does not have the right molecular make-up. A cell displaying molecules produced according to a different blueprint than the body's own code may be recognized as foreign. To eliminate alien material that may harm the body, the immune system must take swift action.

ReCognizing entities that originate outside the self forms the key to overall immune system response. This key is carried in the body by cells called macrophages (ma-kro-fajs), a name derived from a Greek term meaning "big eater." Macrophages eat or engulf foreign cells and molecules. When a macrophage encounters something that it distinguishes as being "non-self" or abnormal, it can attack the enemy with a series of assault weapons, including free-radicals (reactive substances) and enzymes, that dissolve and weaken the intruder. In fact, an enzyme produced by macrophages called lysozyme is recognized as one of nature's most powerful anti-infective agents. These chemical defenses, along with engulfment and complete digestion by macrophages, can effectively stymie invasion by disease-causing pathogens.

Disease Invasion

Harmful invasion can originate in the body's own cells as well as begin from outside sources. While we are constantly exposed to bacteria, viruses, fungal cells and parasites, destructive cancerous growths often start within the body.

Every day, thousands of the body's cells mutate into possible cancers. Under most circumstances, the immune system keeps these cells under control. But when the immune "security" system slips up, these harmful growths multiply unrecognized.

Getting Specific

The initial immune response that recognizes invaders is called a "non-specific defense mechanism" since this immune response is generally the same toward all invaders. This counter-attack entails battling every invader pretty much identically: a macrophage can engage, dissolve, weaken, engulf, digest, eliminate. However, if, despite the initial immune efforts, the problem persists, a macrophage can tag an invader and "introduce" it to the rest of the immune system, thus recruiting more specialized types of immune cells to enter the battle. This tagging function endows macrophages with the name "antigen-presenting cells." (Antigens are substances that can provoke specific responses by the immune system.)

Most antigens are proteins. Proteins are relatively large molecules made of smaller units called amino acids. The specific geometric organization of amino acids is what conveys uniqueness to each protein. (Your genetic code forms a blueprint for the production of your own, individual proteins.) Protein molecules produced by one human being can act as an antigen for another human being. That's why organs transplanted from one person to another can be rejected by the immune system. Unless organs are transplanted from one identical twin to another (who share the genetic blueprint for protein creation), doctors must use immune-suppressing drugs to curtail organ rejection. At the same time as these medicines prevent transplant rejection, they also make people more susceptible to infectious diseases and cancer.

Specialized Immunity

After one set of immune cells chemically tags antigens (invaders) for recognition, other highly specialized parts of the immune system go into action: Cells called T cells or T lymphocytes acknowledge the invaders and can take the further action (second line of defense) that is necessary to render them harmless.

T cells get their name from the thymus (an organ located behind the sternum) where they originate. The thymus, most active when we're young, usually shrinks and apparently slows or shuts down its activity about the age of forty.

A wide variety of T cells inhabit lymph nodes (soft, usually round, pea- or nut-sized organs) and other body areas. For instance, natural killer cells, as their name implies, are a particularly aggressive type of T cell. Another type of T cell is called T helper (a cell that supports development of immune response). T suppressors halt immune response when infection ends.

In order to make all these different cells work in concert, cytokines or messenger molecules are produced that facilitate constant communications between all the parts of the immune system.

The B Team

Other organs of the immune system include:

*bone marrow: a powerful cell producing organ where the majority of immune cells are born;

*spleen: an abdominal organ that forms a reservoir for the production of immune cells.

Lymph nodes oversee particular segments of the body where they collect and recycle tissue fluids. Like an early warning system, lymph nodes react when an invader is detected in the part of the body that it controls.

Yet another step in the so-called immune cascade entails action by lymphocytes, called B cells, which originate in the bone marrow. These cells produce antibodies which are immune proteins (immunglobulins) that attack specific antigens.

While traveling in the blood, an antibody can bind to an antigen, curtailing its harmful action. This bound up molecule forms a complex easily recognized by scavenging macrophages which make a quick meal out of the unlucky invader.

After enemy cells are removed from the body, knowledge of this victory resides in the immunological memory prolonging your resistance toward specific disease pathogens indefinitely. That's why someone who has recovered from a disease like the measles may be impervious to reinfection.

Rules for Optimum Immunity

Even though the immune system consists of a complex team of hard-working cells, enhancing your immunity is relatively easy:

Maintain a healthy lifestyle. Avoid continuous stress and negative emotions or cope with them through exercise or meditation. Consistent, moderate exercise can boost the immune system. Massage can also help although extreme care must be taken when inflammation or disease is already present.

Sleep 7-8 hours a day. Sleep allows the body to recover and rebuild. Protein synthesis, vital for a healthy immune system, increases during the night.

Stick to a healthy diet. Your immune system consists of trillions of cells. Consequently, nutrients important for cell health boost the immune system. A balanced low-calorie diet rich in complex carbohydrates, "good" fats (including fish oils, olive oil and flaxseed oil) along with vitamins, minerals and phytonutrient antioxidants from fresh fruits and vegetables can fortify immune cells. Plus, drinking plenty of water helps improve circulation of lymph fluid.

These recommendations are not hard to meet once they become a part of your daily routine. However, extra immune security may be necessary during flu season, while traveling long distances (airplanes are notorious sources of pathogens) or when working extensive hours in front of a computer screen. In addition, exposure to x-rays, immunosuppressive chemicals, ultraviolet radiation (the sun) or simply aging may give your immune cells extra burdens.

Your "specific" immune system does not respond immediately to the challenge of invasion by an infectious organism. Instead, it may require about 2 weeks for an effective reaction after antigen recognition and alerting T cells. During this period, the macrophages' non-specific defense assumes a crucial role in keeping infection in check.

Enhanced activity by macrophages is especially important for reCognizing and destroying cancer cells. The most dangerous cancers are those that can mimic normal cells and avoid the immune system's wrath. Few substances can activate macrophage function in the body (aloe vera contains substances that contribute to this process). The most powerful macrophage activator recognized by the scientific community is a sugar-like substance called beta-1,3-D-glucan. Beta-glucan, extracted from the cell walls of common Baker's yeast, when taken in certain small amounts, can prevent infection by making macrophages more active in reCognizing and attacking infectious bacteria, fungi and certain viruses.

This kind of activation can encourage macrophages to attack previously unrecognized tumor cells. As a result, tumors may be eradicated as the immune system mobilizes and produces what may be known as "spontaneous healing."

Hungry Macrophages

When a macrophage works overtime fighting disease, its demand for nutrients and energy increases dramatically. Vitamin C, known for its immune supporting function, seems to be especially important for maintaining fully active macrophages. Vitamin C collects in macrophages, often reaching forty times the concentration found in surrounding blood. What are conventionally considered normal amounts of vitamin C in the body may be insufficient to keep macrophages well supplied with this antioxidant. Therefore, extra amounts of vitamin C can keep the immune system in fighting trim.

Scientists are only now beginning to uncover the secrets of the highly organized immune system. One thing's certain: The immunity security team depends on proper lifestyle, nutrition and supplements to maintain the critical defenses necessary for good health.

Dr. Ber received his doctorate in internal medicine from the Yaroslavle, State Medical Institute in Yaroslavle, Russia.

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VitaNet ®
VitaNet ® Staff

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=268)

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