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Search Term: " IP-6 "
Conclusion   
Date:
November 22, 2006 01:45 PM
These three natural discoveries may be some of the most important health discoveries to date. From the mountains of Japan, the rainforests of Peru, and the learned halls of a prestigious university we have been given powerful allies in healthy immunity and cancer prevention. Thankfully, there are formulas available at health food stores that contain all three natural discovery dietary supplements in one convenient product. Our immune systems are continuously assaulted from pollutants in the environment, toxic additives in our food, and common chemicals we use and depend on everyday. These assaults can leave us vulnerable to so-called simple diseases, like colds and the flu, as well as serious problems, such as cancer and autoimmune diseases. Staving off these threats means our white blood cells must stand ready to mount incredibly intricate defenses. Cat’s claw root extract, maitake D-fraction, and IP-6 with inositol provide powerful protection from disease and an all natural boost to our immune system.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1432) Q. If these three natural products are taken together, could they over-stimulate my immune 
Date:
November 22, 2006 01:44 PM
A. That is a very good question. And at first glance, it might seem a possibility. However, one of the most amazing aspects of all three nutritional products, POA cat’s caw root extract, maitake d-fraction, and IP-6 with inositol, is their ability to both strengthen a weakened immune system and calm down a hyperactive immune system. They modulate the immune system. The POAs in Cat’s claw root extract do not take over the immune system’s job, they simply strengthen the body’s immune system so it can do its job better. Maitake D-fraction does not act on cancer cells directly, it encourages the body’s own immune system regulators to act. IP-6 with inositol does not increase NK cells, it increases NK cell activity. In other words, these three natural discoveries strengthen and balance the immune system without the fear or over-stimulation. In fact, it is theorized that cat’s claw root extract, maitake mushrooms, and IP-6 with inositol may work synergistically. Meaning, together they strengthen and balance the immune system even better when they are taken together. However, if you use a cat’s claw supplement that contains any amount of TOAs, not only will the good “spirits” of the POAs be cancelled, experts believe that they will interfere with IP-6 with inositol as well. That’s why it is vital to choose a cat’s claw supplement that is 100% TOA-free and says so on its label.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1431) Q. Why not just take IP-6 by itself? Why does IP-6 need to be combined with inositol?
Date:
November 22, 2006 01:43 PM
A. When scientists studying this combination used plain IP-6 in the laboratory, good cancer preventative effects and good cancer killing effects happened. When scientists used plain inositol in the laboratory, again, good cancer preventative and cancer killing effects occurred. However, when IP-6 was combined with inositol, powerful cancer killing and cancer preventative effects happened. Clearly, IP-6 with inositol is the superior choice in cancer prevention. Scientists are interested in the very unique way IP-6 works in our body. One theory of how this combination exerts its effects is that IP-6 mixed with inositol breaks down into IP-3 in the body. IP-3 is more active than IP-6, but is very unstable. That is why it is so important to use a product that is an exact combination of IP-6 and inositol, precursors that are both needed to yield the maximum amount of IP-3 needed for immune stimulation and cancer growth inhibition.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1430) Q. If IP-6 comes from bran, wouldn’t eating more whole grain or high fiber foods = IP-6
Date:
November 22, 2006 01:42 PM
A. Scientists who study a specific IP-6 and inositol blend asked this very same question and went to the laboratory to find the answer. They took cancerous tumors and exposed them to either the nutrients of fiber and bran, or to IP-6. The nutrients of the fiver and bran were the equivalent of a 20% bran diet. The scientists discovered that the IP-6 was twice as effective as the nutrients of the 20% bran diet. In bran or fiber, IP-6 is bound to protein. For IP-6 to be well absorbed in the stomach, enter the bloodstream, and travel to the various organs where cancer has occurred, the IP-6 must first be separated from the protein. This normally happens with digestion, but it can take awhile and is inefficient. Phytase, an enzyme found in food and also the intestine, can actually break down IP-6, making it ineffective as a cancer fighter. The longer it takes IP-6 to be released from food, the more time phytase has to break down IP-6 to an ineffective form. Pure IP-6 is better, because it will be absorbed into the bloodstream before phytase has a chance to destroy it.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1429) Q. How does IP-6 with inositol help the immune system?
Date:
November 22, 2006 01:41 PM
A. Scientists who study IP-6 with inositol have discovered many amazing things how this combination works. While many cancer drugs work by killing all cells, both cancerous and normal, IP-6 with inositol only affects cancer cells. When cancer cells in the laboratory are exposed to IP-6 with inositol, they lose their aggressive nature, stop dividing uncontrollably, and eventually die. The combination of IP-6 with inositol does not affect normal cells. Researchers have also discovered that this powerful combination boosts the activity of natural killer (NK) cells, those important white blood cells that “naturally” kill cancer cells. Increased NK cell activity can result in the increased killing of cancer cells, as well as cells infected by viruses. And, finally, researchers have discovered that IP-6 with inositol also acts like an antioxidant to help prevent cellular damage.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1428) Q. What is IP-6 with inositol?
Date:
November 22, 2006 01:41 PM
A. In the m id 1980s, scientists at the University of Maryland were studying various plant fibers and how they affected our health. They were particularly interested in fiber and cancer. They discovered that fiber and bran contain many natural components. One of these components, IP-6, has been studied extensively for over 20 years. IP-6 is the abbreviation for the inositol hexaphosphate, an all-natural substance found in the bran of brown rice. IP-6 is also referred to as phytic acid. Inositol is part of the B vitamin group, and IP-6, in a special and specific combination with inositol, had powerful effects on the immune system.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1427) Cancer, The Immune System, and Nutritional Supplements
Date:
November 22, 2006 01:31 PM
This is a tale of three discoveries. One transpired deep in the rainforests of Peru. Another happened high in the mountains of Japan. And the third discovery occurred in a university on the East Coast of the United States. All of these discoveries resulted in amazing all-natural nutritional supplements. All of these nutritional supplements have powerful effects on the human immune system. And, while each of these natural nutritional supplements help prevent and treat immune diseases individually, together they may work even more powerfully to help strengthen our immunity and keep us cancer-free. In this issue of Ask the Doctor, we will learn about these three important natural discoveries: namely, POA cat’s claw root, maitake mushrooms, and IP-6 with inositol. We will discover for ourselves how these all-natural supplements work directly on specific cells of the immune system to protect us from cancer and boost our immunity.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1422) AHCC® Fact Sheet - from Now Foods.
Date:
December 08, 2005 10:20 AM
AHCC® Fact SheetNeil E. Levin, CCN, DANLA 6/30/05LIKELY USERS: People needing increased activity of their Natural Killer cells; People seeking improved immune system response; People with a need for tissue repair; People with oxidative challenges; People seeking to increase liver function People defying aging or with a need to improve cellular integrity. KEY INGREDIENTS: AHCC® (Active Hexose Correlated Compound) MAIN PRODUCT FEATURES: AHCC® is a proprietary extract produced from specially cultivated and hybridized mushrooms. According to extensive research in humans, as well as numerous non-clinical studies, AHCC®supports immune system function through its effects on macrophages and NK (Natural Killer) Cells. NK cells and the intercellular mediators they produce are critical for the maintenance of healthy cell cycle function. AHCCR® has also been shown possess antioxidant properties, and supports healthy liver function. ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: AHCC® (Active Hexose Correlated Compound) is a patented ingredient that has been the subject of research studies. It is supported by the scientific staff in the laboratories of both NOW Foods and the raw material supplier, both of which have a mutual interest in protecting the integrity and efficacy of this product. AHCC® is a rich source of polysaccharides such as beta glucan 1,3 and activated hemicellulose produced by enzymatic modification of organic medicinal mushrooms, including shiitake. It also has been shown to support normal levels of macrophages and cytokines, further strengthening the immune system. This formula is suitable for vegetarians and is offered in Vcaps. SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, take 2 Vcaps® 3 times daily, preferably on an empty stomach. COMPLEMENTARY PRODUCTS: Antioxidants, Astragalus, Colostrum, Dr. Verghese Liver Formula, Immune Renew, Indole-3-Carbinol (I3C), Inositol Hexaphosphate (IP-6), CAUTIONS: None. PRODUCT SPECIFIC: None GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. When taking any new supplement, use common sense and cautiously increase to the full dose over time to avoid any potential problems. Packages may contain moisture or oxygen controlling packets or canisters that are not intended for consumption. In order to maintain maximum freshness, please do not remove these from your bottle (until the bottle is empty). Please recycle your container. DISCLAIMER: Information given here may vary from what is shown on the product label because this represents my own professional knowledge and understanding of the science underlying the formula and ingredients. The information in this review should not be used as diagnosis, prescription or as a specific product claim. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES: Aviles H, Belay T, Fountain K, Vance M, Sun B, Sonnenfeld G. (2003) Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infectin in mice in the hindlimb-unloading model of spaceflight conditions. J Appl Physiol 95:491-496. Burikhanov RB, Wakame K, Igarashi Y, Wang S, Matsuzaki S (2000) Suppressive Effect of Active Hexose Correlated Compound (AHCC®) on Thymic Apoptosis Induced by Dexamethasone in the Rat. Endocrine Regulations 34:181-188. Matsui Y, et al. (2002) Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. J Hepatol. 2002 Jul;37(1):78-86. PMID: 12076865 Matsushita K, et al. (1998) Combination therapy of active hexose correlated compound plus UFT significantly reduces the metastasis of rat mammary adenocarcinoma. Anti-Cancer Drugs 9:343-350. Sun B, Wakame K, Mukoda T, Toyoshima A. Kanazawa T, Kosuna K (1997) Preventive Effects of AHCC® on Carbon Tetrachloride Induced Liver Injury in Mice. Nat Med 51(4):310-315. Ye SF, Ichimura K, Wakame K, Ohe M. Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress. Life Sci. 2003 Dec 19;74(5):593-602. PMID: 14623030 Ye SF, Wakame K, Ichura K, Matsuzaki S (2004) Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat. Endocr Regul 38(1):7-13.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=993) Astragalus Fact Sheet
Date:
December 07, 2005 01:15 PM
Astragalus Fact SheetNeil E. Levin, CCN, DANLA 02/10/05LIKELY USERS: Everyone seeking a healthy immune system; Those lacking energy KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg) MAIN PRODUCT FEATURES: A Chinese “tonic herb” used in Traditional Chinese Medicine for night sweats, diarrhea and lack of energy. Tonic herbs are often known as “adaptogens”, helping the body adapt to stresses and modulating immune system responses. Some reports credit Astragalus with shortening colds and strengthening the heart.Astragalus additionally contains triterpene glycosides, also known as astragalosides. ADDITIONAL PRODUCT INFORMATION: Vegetarian formula.May be useful to maintain the patient’s immunity in dialysis patients, those with liver problems and those who have suffered from strokes, according to Chinese studies (not as a treatment for those conditions!). SERVING SIZE & HOW TO TAKE IT: For everyday use take one to five caps per day, either with meals or on an empty stomach. COMPLEMENTARY PRODUCTS: Immune Renew, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and other antioxidants. CAUTIONS: Pregnant & lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease, though there is some (not enough) evidence that Astragalus may balance immune function for at least one autoimmune disorder. This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
REFERENCES: 1. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000 Jul;7(7):715-29.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=984) Immune Renew Fact Sheet
Date:
December 07, 2005 01:07 PM
Immune Renew Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05 LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg) MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth. ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach. COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect. This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=983) Takeing Cat's Claw, IP-6 and Maitake Mushroom over stimulate immune system?
Date:
November 11, 2005 06:33 PM
Q. If these three natural products are taken together, could they over-stimulate my immune system? A. That is a very good question. And at first glance, it might seem a possibility. However, one of the most amazing aspects of all three nutritional products, POA cat’s claw root extract, maitake d-fraction, and IP-6 with inositol, is their ability to both strengthen a weakened immune system and calm down a hyperactive immune system. They modulate the immune system. The POAs in cat’s claw root extract do not take over the immune system’s job, they simply strengthen the body’s immune system so it can do its job better. Maitake D-fraction does not act on cancer cells directly, it encourages the body’s own immune system regulators to act. IP-6 with inositol does not increase NK cells, it increases NK cell activity. In other words, these three natural discoveries strengthen and balance the immune system without the fear of over-stimulation.
In fact, it is theorized that cat’s claw root extract, maitake mushrooms, and IP-6 with inositol may work synergistically. Meaning, together they strengthen and balance the immune system even better when they are taken together. However, if you use a cat’s claw supplement that contains any amount of TOAs, not only will the good “spirits” of POAs be cancelled, experts believe that they will interfere with IP-6 with inositol as well. That’s why it is vital to choose a cat’s claw supplement that is 100% TOA-free and says so on its label.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=940) Why does IP-6 need to be combined with inositol?
Date:
November 11, 2005 06:30 PM
Q. Why not just take IP-6 by itself? Why does IP-6 need to be combined with inositol? A. When scientists studying this combination used plain IP-6 in the laboratory, good cancer preventative effects and good cancer killing effects happened. When scientists used plain inositol in the laboratory, again, good cancer preventative and cancer effects occurred. However, when IP-6 was combined with inositol, powerful cancer killing and cancer preventative effects happened. Clearly, IP-6 with inositol is the superior choice to cancer prevention. Scientists are interested in the very unique way IP-6 works in our body. One theory of how this combination exerts its effects is that IP-6 mixed with inositol breaks down into IP-3 in the body. IP-3 is more active than IP-6, but is very unstable. That is why it is so important to use a product that is an exact combination of IP-6 and inositol, precursors that are both needed to yield the maximum amount of IP-3 needed for immune stimulation and cancer growth inhibition.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=939) If Ip-6 comes from bran, wouldn’t eating more whole grain or high fiber foods provide IP6
Date:
November 11, 2005 06:30 PM
Q. If IP-6 comes from bran, wouldn’t eating more whole grain or high fiber foods provide IP-6? A. Scientists who study a specific IP-5 and inositol blend asked this very same question and went to the laboratory to find the answer. They took cancerous tumors and exposed them to either the nutrients of fiber and bran, or to IP-6. The nutrients of fiber and bran were the equivalent of 20% bran diet. The scientists discovered that the IP-6 was twice as effective as the nutrients of the 20% bran diet. In bran or fiber, IP-6 is bound to protein. For IP-6 to be well absorbed in the stomach, enter the bloodstream, and travel to the various organs where cancer has occurred, the IP-6 must first be separated from the protein. This normally happens with digestion, but it can take awhile and is inefficient. Phytase, an enzyme found in food and also the intestine, can actually break down IP-6, making it ineffective as a caner fighter. The longer it takes IP-6 to be released from food, the more time phytase has to break down IP-6 to an ineffective form. Pure IP-6 is better, because it will be absorbed into the bloodstream before phytase has a chance to destroy it.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=938) How does IP-6 with inositol help the immune system?
Date:
November 11, 2005 06:29 PM
Q. How does IP-6 with inositol help the immune system? A. Scientists who study IP-6 with inositol have discovered many amazing things how this combination works. While many cancer drugs work by killing all cells, both cancerous and normal, IP-6 with inositol only affects cancer cells. When cancer cells in the laboratory are exposed to IP-6 with inositol, they lose their aggressive nature, stop dividing uncontrollably, and eventually die. The combination of IP-6 with inositol does not affect normal cells. Researches have also discovered that this powerful combination boosts the activity of natural killer (NK) cells, those important white blood cells that “naturally” kill cancer cells. Increased NK cell activity can result in the increased killing of cancer cells, as well as cells infected by viruses. And, finally, researchers have discovered that IP-6 with inositol also acts like an antioxidant to help prevent cellular damage.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=937) What is IP-6 with inositol?
Date:
November 11, 2005 06:28 PM
Q. What is IP-6 with inositol? A. In the mid 1980s, scientists at the University of Maryland were studying various plant fibers and how they affected our health. They were particularly interested in fiber and cancer. They discovered that fiber and bran contain many natural components. One of these components, IP-6, has been studied extensively for over 20 years. IP-6 is the abbreviation for inositol hezxaphosphate, an all-natural substance found in the bran of brown rice. IP-6 is also referred to as phytic acid. Inositol is part of the B vitamin group, and IP-6, in s special and specific combination with inositol, has powerful effects on the immune system.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=936) Cancer at the Millenium - the war on cancer entering its third decade... 
Date:
June 13, 2005 10:23 AM
Cancer at the Millenium by Harriet Brown Energy Times, May 1, 1999 With the war on cancer entering its third decade, the necessity grows clearer for medical science to engage the enemy on several fronts. Until recently, high-tech medical weapons like vaccines and gene therapy, inspired by a flood of insights into the molecular basis of cancer, garnered most of the hope, hype, headlines and research money. The science was sexy and the prospect of a "cure" dramatic. But, today, advocates of prevention receive equal, if not greater, attention. Improving our diets and prudently supplementing with vitamins and minerals, can deliver a major preventive impact. Contentious experts concede that at least a third (and probably more) of all cancers can be blamed on a combination of eating too much of the wrong foods and not enough of the right ones. The Dietary Difference Though cancer can progress rapidly once it leaps past its inception, it develops over many years and in several stages. Beneficial compounds in food and supplements may intervene along a line that runs from initial exposure to carcinogens to the final step into outright malignancy. Nutrients may: - counteract environmental poisons and the toxic byproducts of liver metabolism The Big Picture The dietary guidelines advocated by the American Cancer Society and the National Cancer Institute (which generally coincide with those of most health organizations) may sound familiar: Eat plenty of fruits and vegetables. Get lots of fiber. Limit fat, especially animal fat. Go easy on meat and avoid the cured variety (they contain nitrites). If you drink alcohol, do it in moderation. Watch your total calories, and your weight. Pretty straightforward stuff. Carotenoid Characteristics Carotenoids, as their name suggests, are orange and red pigments in fruits and vegetables, most notably carrots and tomatoes, although they're also in everything from sweet potatoes to spinach and brussels sprouts (in the latter their distinctive color is masked by green chlorophyll). Lycopene, a carotenoid found primarily in tomatoes, displays double the free radical-fighting activity of beta carotene, the most widely studied carotenoid. Of 72 studies looking at consumption of tomatoes or tomato-based products reviewed in the February 1999 Journal of the National Cancer Institute, almost half showed a significant reduction in one or more of a variety of cancers. Research shows that lycopene may be best at lowering a man's risk of prostate cancer. A 1995 Harvard Medical School study (Journal of the National Cancer Institute 1995; 87: 1767-76) queried nearly 48,000 male health-care professionals about their consumption of fruits and vegetables. The only foods that reduced their risk of prostate cancer were, apparently, tomato sauce, tomatoes, pizza (tomato paste). For those who ate ten servings a week, risk dropped 45 percent; with four to seven servings, 20 percent. In animal studies lycopene decreased the number and size of mammary tumors (Eleventh International Symposium on Carotenoids, 1996). Tomatoes are one of the richest sources of lycopene. Cooking tomatoes helps by releasing the lycopene from the plant cell walls. Also, the oil in tomato sauce enhances absorption in the stomach. Lycopene is also available in supplements. Unreserved Resveratrol Wine drinkers rejoiced when resveratrol, a constituent of the skin of red grapes, was found to protect their hearts (by blocking oxidation of LDL cholesterol and discouraging blood clotting). Now they have another reason to toast this potent antioxidant. When researcher John Pezzuto at the University of Illinois at Chicago screened about 1,000 plants for anticancer activity, he came up with one whose active ingredient turned out to be resveratrol. In lab tests it squelched both free radicals and inflammation, two well-known cancer inducers (Science, 6/10/97). In a study with mice, resveratrol reduced the number of skin tumors by up to 98 percent compared to control animals. Because the effective doses were high (Pezzuto estimates a person would have to quaff about five gallons of wine a day to get the equivalent) and because more than a drink or two a day may raise the risk of breast cancer, researchers don't recommend nondrinkers take up wine. But supplements of synthesized resveratrol (as well as grape juice) may help. Fat Chance Saturated fat is an authentic dietary villain. Aside from clogging arteries, it's a suspected contributor to several cancers, though the evidence is greater for some cancers (prostate) than for others (breast cancer) Of the two other main categories of fats, monounsaturated and polyunsaturated, mono seems benign, if not positively protective. For example, in a study of the influence of diet on breast cancer, Greek researchers discovered that women who consumed higher amounts of olive oil (which is mostly mono) were less likely to be afflicted with breast cancer (Journal of the National Cancer Institute 1995: 87; 110-116). When it comes to polyunsaturated fats, however, things get complicated. The fat that predominates in corn, sunflower and other vegetable oils, called omega-6, has long been associated with cancer risk in animal experiments. Likewise the type found in margarines, trans fats, which are partially saturated vegetable oils. On the other hand, the omega-3 fats called EPA and DHA, which are found primarily in deep- and cold-water fish like cod, mackerel, and halibut, protect against both heart disease and cancer. In an epidemiological study covering 24 European countries, British researchers established that mortality rates for colon and breast cancers declined as fish and fish oil consumption rose (British Journal of Cancer 1996: 74; 159-64). And Finnish scientists discovered that the breast tissue of women who had breast cancer contained significantly less DHA and EPA than the breasts of healthy women (Nutrition and Cancer 1995: 24; 151-160). Experts believe the omega-3s' anticancer effect derives from its ability to tamp down the prostaglandins that stimulate inflammation. Chronic inflammation unleashes a steady stream of free radicals, which can damage DNA and thereby trigger cancer. Omega-3s also help the liver detoxify potentially harmful substances. Fortunately for the fish-phobic, nonmarine sources of omega-3 fats include flaxseed and hemp oils. Minerals to Lower Cancer Risk n Calcium: possibly protective against colon cancer. In a recent trial (New England Journal of Medicine, 1/14/99) researchers gave people with a history of precancerous colon polyps either two 600 mg calcium tablets a day or a placebo for nine months and found fewer polyps. n Selenium: powerful antioxidant and supporter of immunity. Researchers find that cancer rates in various regions is lowered when soil and vegetables contain more selenium In a selenium-depleted area in China afflicted with one of the highest incidences of stomach and esophageal cancer mortality in the world, scientists asked different groups to take various combinations of nutrients. After five years they found a significant reduction in the cancer rate among those who had gotten supplements of selenium, vitamin E and beta carotene (Biological Trace Element Research 1985; 7: 21-29). In the U.S. researchers studying the potential effectiveness of selenium supplementation for preventing nonmelanoma skin cancers came up with a surprise. The 200 mcg a day the subjects received for an average of 4.5 years had no impact on skin cancer but did significantly cut the rates of lung, colorectal and prostate cancers (Journal of the American Medical Association, 12/25/96). More recently Harvard researchers determined that men with prostate cancer had much lower levels of selenium in their toenails (a measure of consumption) than healthy men (Journal of the National Cancer Institute, 8/119/98). Cruciferous Vegetables Cruciferous vegetables like broccoli, brussels sprouts, cauliflower and kale, have long been singled out for their association with protection against cancer. In a 1996 survey of 94 population studies and clinical trials focusing on consumption of cruciferous vegetables, 67 percent showed a reduced risk, the strongest link being with lung, stomach, colon and rectal cancers (Cancer Epidemiological Biomarkers 1996; 5: 733-748). Scientists at Johns Hopkins showed that sulforaphane, from these plants, stimulates enzymes that help detoxify carcinogens generated in the liver. When they injected rats with a cancer-causing chemical, only 26 percent of the rodents pretreated with sulforaphane developed mammary cancer, compared to 68 percent of controls. Even animals who did come down with cancer had tumors that appeared later and smaller. Other researchers have focused on a cruciferous-vegetable compound called indole-3-carbinol, which has proved especially effective against breast cancer cells. Recently, scientists at the University of California at Berkeley found that indole-3-carbinol, rather than acting as an anti-estrogen, (as had been thought), actually stops breast cancer cells by turning off a protein critical to their replication (Jrnal of Bio Chem, 2/13/98). Consequently, when treating certain forms of cancer, some doctors have paired indole-3-carbinol with the chemotherapy drug tamoxifen - which counteracts estrogen - and found that the combination has proven more potent than either separately. Fiber Several decades ago British physician Denis Burkitt proposed that the low incidence of colon cancer among native peoples in South Africa was attributable to the fact that their diet was rich in fiber. The fiber, it was hypothesized, bulked up the stool, speeding its passage through the bowel and reducing the time carcinogens contact its lining; it also helped neutralize cancer-promoting bile acids. This concept has been backed up by numerous studies. Recently, Harvard researchers sprinkled cold water on this idea, finding that an examination of the eating habits of more than 80,000 female nurses, could find no protective effect against colon cancer or precancerous polyps from consuming fiber (NEJM, January 21, 1999). Most experts' take on this apparent refutation: Maybe the "high fiber" intake in this case wasn't high enough, and this is just one study among many. Fighting Breast Cancer Fiber has also been linked to reduced rates of breast cancer. At first it was thought that if fat was a breast-cancer culprit, fiber might just be a marker for a low-fat diet. But a look at Finland undermined that idea: Finnish women eat both a lot of fat and a lot of fiber, and their breast cancer rate ranks much below that in the U.S., (where we eat gobs of fat and little roughage). Fiber helps take estrogen out of circulation as it passes through the liver, while the isoflavones in many high-fiber plants and vegetables are themselves weak estrogens, which compete for slots on breast tissue's estrogen receptors. The special fiber in flaxseed oil called lignans act against estrogen in two ways: by binding its receptors and by inhibiting the enzyme that converts other hormones into estrogen. Fiber comes in two basic forms, insoluble (e.g., wheat bran, celery, the skins of fruits and vegetables) and soluble (e.g., oat bran, citrus fruits, beans). Until a few years ago, scientists believed that cancer protection came mainly from insoluble fiber, but that thinking has turned around. A soluble fiber called citrus pectin has been shown to halt the tendency of prostate, lung, breast and skin cancers to metastasize, or spread (e.g., Journal of the National Cancer Institute 1995; 87: 3448-353). Typically cancer turns deadly only when it gets into the bloodstream and invades new territory. Modified citrus pectin appears to stop this aggression by preventing cancer cells from attaching to healthy tissue. Novel Antioxidant While the name inositol hexaphosphate (IP6) sounds like a mouthful, many of us consume mouthfuls of this natural substance every day - in foods like corn, rice, whole-grain cereals, oats and wheat. But now scientists have isolated IP-6 and found that this powerful antioxidant can slow the destructive cellular processes that lead to tumors. In a study published in Anti-Cancer Research (Nov/Dec 1998), scientists at the University of Maryland School of Medicine demonstrated that IP-6 could shrink liver tumors in laboratory animals. The researchers believe that IP-6 can help prevent cancer and also be useful in lowering the risk of health problems like kidney stones and heart disease. Research like this continues to expand our knowledge of how to lower the risk of cancer. In the next millennium, with more and more information making its way into the media and onto websites, our power and the responsibility to reduce our risk of cancer will continue to grow and offer new possibilities.
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