Search Term: " Trans-Resveratrol "
Prostate Health - Clinical Strength
May 28, 2010 01:50 PM
Clinical Strength Prostate Health
Medical professionals, health experts, and researchers now concur that approximately one in three men over thirty will face some form of prostate challenge during their lifetime. One of the most frequently encountered is BPH, or Benign Prostatic Hyperplasia. This common, non-cancerous condition occurs in aging males as a result of normalized shifts in hormonal production. While the exact cause of BPH continues to intrigue the research community, findings from ongoing studies have indicated that it may be linked to excess free testosterone reaching the prostate gland in high concentrations, or possibly excess production of DHT, or dihydrotestosterone, a natural testosterone metabolite. Current research is looking at possible estrogenic causes, as well. While the volume of men affected by BPH is indeed concerning, hope for supporting optimal prostate function, once only within view of the health horizon, is now a very real and accessible alternative option.
The constant evolution of nutraceutical science has explored many ways in which to support the physiology and function of a healthy prostate gland. Keeping in mind that natural products are not intended to treat or cure BPH, well-conducted studies have showcased the ability of several nutritionals in providing support for normal prostate health. The most recognized is Saw Palmetto; a popular, effective natural extract which needs no formal introduction to health enthusiasts or supplement-savvy retailers. Others, too, appear to help sustain normal prostate function. These include Pumpkin Seed Oil, Lycopene, Stinging Nettle, Quercetin, Phytosterols, and numerous others. The results of these findings, coupled with growing consumer interest in natural alternatives, have come together in our newest addition to NOW’s line of male support products.
Clinical Strength Prostate Health is a science-inspired formula developed to deliver the pinnacle of nutritional support for healthy prostate function.* Each 3 softgel serving supplies 320 mg of Saw Palmetto Berry extract (min. 85% fatty acids), along with Pumpkin Seed Oil, Zinc, Selenium, Natural Trans-Resveratrol, Vitamin D-3 and other potent synergists. 850 mg of Phytosterols, including eta-Sitosterol, is represented, as well as standardized extracts from Nettle Root, Turmeric, Green Tea, Pomegranate, and Flax Seed Lignans. This novel arrangement of thoroughly researched compounds makes Clinical Strength Prostate Health the last natural prostate support formula* male enthusiasts will ever need. As with every NOW® product, we formulate using only the best raw materials, under the most exacting quality standards, offered at prices that yield high margins and even happier customers.
Pomeratrol™ Fact Sheet
December 19, 2005 09:09 AM
Pomeratrol™ Fact SheetNeil E. Levin, CCN, DANLA 9/28/04
USER: Those needing antioxidant protection; People with a family history of cell growth abnormalities; Anyone concerned with aging
KEY INGREDIENT(S): Pomegranate fruit standardized extract 200 mg. (Punica granatum) containing 80% total polyphenols, including 40% Ellagic acid, Resveratrol (100% Trans-Resveratrol) 20 mg. from a blend of Japanese knotweed root extract (Polygonum cuspidatum) and grape skin extract (Vitis vinifera)
POTENTIAL BENEFITS: Ellagic acid is a polyphenol compound found in raspberries, strawberries, pomegranates, and other fruit. It has been shown to normalize cell death of abnormal cells, a process called apoptosis. This enhances the body’s cell growth control system by providing an important plant substance. It may bind to DNA to prevent damage to this all-important genetic material. This is a key step in preventing cell damage that leads to signs of aging.
The American Cancer Society says that research in animal and laboratory models has found that ellagic acid inhibits the abnormal growth of certain cells. Research at Ohio State University indicates that berries typically contain a few milligrams per ounce of ellagic acid, the actual level varying quite a bit from variables such as species, variety and growing conditions.
Resveratrol is an antioxidant compound that is a phytoestrogen, or plant estrogen, which is protective of hormone-mediated cells in the body. Resveratrol is a potent antioxidant if stabilized. If not stable, it may quickly metabolize out of the body. This compound is believed responsible for some of the beneficial effects of moderate red wine drinking on the cardiovascular system. Resveratrol is also considered to be beneficial to smokers’ lung tissue if it is stabilized to last long enough in the system to be transported there. Resveratrol is also an inhibitor of the COX-2 inflammatory enzyme and encourages cell death (apoptosis) of abnormally growing cells. In insect experiments resveratrol even repaired DNA, leading to a longer life for healthy cells even as it helped get rid of unhealthy cells. Again, this ability to protect cells and help the body rid itself of abnormal cells is a key factor in preventing signs of aging. One liter of red wine contains between 1.5 and 3 mg. of resveratrol.
OTHER IMPORTANT ISSUES: Resveratrol is a difficult substance to stabilize. Because of the difference between resveratrol produced in the oxygen-poor environment in red wine and the form of resveratrol in unstabilized supplements, it has long been thought that resveratrol supplements were not very effective in comparison with wine. Knowing the importance of how a resveratrol supplement is metabolized, Now’s scientific staff has recently developed a special technique of stabilizing this compound in order to have an antioxidant effect closer to drinking a good glass of wine. While both trans and cis forms of resveratrol are naturally occurring, most of the recorded health benefits are attributed to the trans form. Now’s Pomeratrol provides Trans-Resveratrol.
DOSE: One capsule per day. Resveratrol has been used safely in studies at doses equivalent to 500 mg./day.
COMPLEMENTARY PRODUCTS: Other antioxidants and plant compounds: Vitamin C, pycnogenol, grape seed extract, and alpha lipoic acid.
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. There are some indications that resveratrol is a mild anticoagulant ("blood thinner"), and it also may help keep blood vessels to remain open and flexible. Caution should be used by those on blood-thinning drugs. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
December 19, 2005 09:06 AM
Pomeratrol™ - NOW® Pomeratrol™ gets its anti-aging properties from two cell protecting agents, pomegranate and Trans-Resveratrol. Fueled by powerful antioxidant compounds that include polyphenols (standardized to 80%) and anthocyanidins, pomegranate is also high in ellagic acid (standardized to 40%) that helps support healthy cellular function. In addition, the trans- Resveratrol in Pomeratrol™ is a hard-working antioxidant that helps sustain healthy cell cycles while protecting against DNA damage. This combination encourages normal cellular growth and renewal – a key factor in healthy aging.
Red Wine and Resveratrol
May 23, 2005 09:20 AM
The red wine phenolics Trans-Resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis:
Implications for protection against coronary heart disease Authors: Pace-Asciak, Cecil R.a; Hahn, Susanb; Diamandis, Eleftherios P.b; Soleas, Georgec; Goldberg, David M. Affiliations: a. Department of Pharmacology, University of Toronto and Research Institute, Hospital for Sick Children, Toronto, Canada b. Department of Clinical Biochemistry, University of Toronto, 100 College Street, Banting Institute, Toronto, Ontario, M5G 1L5, Canada c. Andres Wines Ltd., Grimsby, Ontario, Canada Keywords: Atherosclerosis; Thromboxane B2; Hepoxilins; Anti-oxidants; Resveratrol; Quercetin
A number of lines of evidence suggest that red wine may be more effective than other alcoholic beverages in decreasing the risk of coronary heart disease (CHD) mortality. This protection over and above that due to ethanol itself may be explained by phenolic components with which red wines are richly endowed. We have studied the effects of the trihydroxy stilbenetrans -resveratrol on human platelet aggregation and on the synthesis of three eicosanoids from arachidonate by platelets, i.e. thromboxane B2 (TxB2), hydroxyheptadecatrienoate (HHT) and 12-hydroxyeicosatetraenoate (12-HETE). These effects were compared with the actions of other wine phenolics (quercetin, catechin and epicatechin) and antioxidants (a-tocopherol, hydroquinone and butylated hydroxytoluene). trans-Resveratrol and quercetin demonstrated a dose-dependent inhibition of both thrombin-induced and ADP-induced platelet aggregation, whereas ethanol inhibited only thrombin-induced aggregation. The other compounds tested were inactive. Trans-Resveratrol also inhibited the synthesis of TxB2, HHT, and to a lesser extent 12-HETE, from arachidonate in a dose-dependent manner. Quercetin inhibited only 12-HETE synthesis, and hydroquinone caused slight inhibition of TxB2 synthesis, the remaining compounds being ineffective. De-alcoholized red wines inhibited platelet aggregation; their ability to inhibit the synthesis of TxB2 but not that of 12-HETE from labelled arachidonate by washed human platelets was proportional to their Trans-Resveratrol concentration. These results are consistent with the notion that Trans-Resveratrol may contribute to the presumed protective role of red wine against atherosclerosis and CHD.