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Supplements that provide nutritive support for healthy cardiovascular health

Resveratrol - support for healthy cardiovascular health	Darrell Miller	05/23/05
Red Wine and Resveratrol	Darrell Miller	05/23/05

Date: May 23, 2005 09:11 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Resveratrol - support for healthy cardiovascular health

The following abstract proved that Resveratrol improves cardiovascular health:

Mechanisms of Cardiovascular Protection by Resveratrol. Hao, Han Dong; He, Li Ren. Postgraduate School, Shanghai University of Traditional Chinese Medicine, Peop. Rep. China. Journal of Medicinal Food (2004), 7(3), 290-298. CODEN: JMFOFJ ISSN: 1096-620X. Journal; General Review written in English. CAN 142:147537 AN 2004:763821 CAPLUS

Abstract

A review. The phytoantitoxin resveratrol is a plant-derived polyphenol with phytoestrogenic properties. Resveratrol protects the cardiovascular system by mechanisms that include defense against ischemic-reperfusion injury, promotion of vasorelaxation, protection and maintenance of intact endothelium, anti-atherosclerotic properties, inhibition of low-d. lipoprotein oxidn., suppression of platelet aggregation, and estrogen-like actions.

Keeps lipids flowing smoothly through the blood system and helps prevent them from sticking the the artery walls.

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Date: May 23, 2005 09:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Red Wine and Resveratrol

The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis:

Implications for protection against coronary heart disease Authors: Pace-Asciak, Cecil R.a; Hahn, Susanb; Diamandis, Eleftherios P.b; Soleas, Georgec; Goldberg, David M. Affiliations: a. Department of Pharmacology, University of Toronto and Research Institute, Hospital for Sick Children, Toronto, Canada b. Department of Clinical Biochemistry, University of Toronto, 100 College Street, Banting Institute, Toronto, Ontario, M5G 1L5, Canada c. Andres Wines Ltd., Grimsby, Ontario, Canada Keywords: Atherosclerosis; Thromboxane B2; Hepoxilins; Anti-oxidants; Resveratrol; Quercetin

Abstract:

A number of lines of evidence suggest that red wine may be more effective than other alcoholic beverages in decreasing the risk of coronary heart disease (CHD) mortality. This protection over and above that due to ethanol itself may be explained by phenolic components with which red wines are richly endowed. We have studied the effects of the trihydroxy stilbenetrans -resveratrol on human platelet aggregation and on the synthesis of three eicosanoids from arachidonate by platelets, i.e. thromboxane B2 (TxB2), hydroxyheptadecatrienoate (HHT) and 12-hydroxyeicosatetraenoate (12-HETE). These effects were compared with the actions of other wine phenolics (quercetin, catechin and epicatechin) and antioxidants (a-tocopherol, hydroquinone and butylated hydroxytoluene). trans-Resveratrol and quercetin demonstrated a dose-dependent inhibition of both thrombin-induced and ADP-induced platelet aggregation, whereas ethanol inhibited only thrombin-induced aggregation. The other compounds tested were inactive. trans-Resveratrol also inhibited the synthesis of TxB2, HHT, and to a lesser extent 12-HETE, from arachidonate in a dose-dependent manner. Quercetin inhibited only 12-HETE synthesis, and hydroquinone caused slight inhibition of TxB2 synthesis, the remaining compounds being ineffective. De-alcoholized red wines inhibited platelet aggregation; their ability to inhibit the synthesis of TxB2 but not that of 12-HETE from labelled arachidonate by washed human platelets was proportional to their trans-resveratrol concentration. These results are consistent with the notion that trans-resveratrol may contribute to the presumed protective role of red wine against atherosclerosis and CHD.

red wine with alcohol removed or present reduced platelet aggregation - preventing platelets from sticking to the artery walls.

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