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Glutathione Is A Powerful Antioxidant For The Liver

Glutathion, Antioxidants, And The Body

Darrell Miller

07/14/10

Date: July 14, 2010 02:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Glutathion, Antioxidants, And The Body

Glutathione is a simple protein that consists of three amino acids. These amino acids include glutamic acid, cysteine, and glycine. Due to the chemical nature of sulphur-containing cysteine, glutathione is able to effortlessly donate electrons. This ability is the reason why it has powerful antioxidant properties. Intracellular glutathione status is a sensitive indicator of cellular health and of the cell’s ability to resist toxic challenges.

Glutathione is an important water-phase antioxidant that is an essential component in the glutathione peroxidase system. Glutathione peroxidase enzymes are crucial for detoxifying peroxides including hydrogen peroxide, which is generated within cellular membranes and lipid-dense areas of the cell, especially the mitochondrial membrane. Severe glutathione depletion often leads to cell death, while experimental glutathione depletion has been found to induce cellular apoptosis.

A cellular level of glutathione depletion seems to cause extensive damage to the mitochondria. Depletion of mitochondrial glutathione may, in fact, be the ultimate factor that determines a cell’s vulnerability to oxidative(free radical) attack. The mitochondria is the most crucial place for glutathione presence, as the cascade of oxidation-reduction reactions complete the final steps in respiration take place here. Throughout this process, which is called oxidative phophorylation, electrons invariably escape and react with the ambient oxygen in order to generate toxic free radicals. It has been estimated that 2% to 5% of the electrons that enter the mitochondria are converted into reactive oxygen species that generate considerable oxidative stress for the cell. These free radicals cause an immediate threat to other cellular components, such as the DNA, enzymes, structural proteins, and lipids.

The cumulative damage that is caused by oxygen and other free radical species is now determined to be the principal contributor to the degenerative disease process and the progressive loss of organ function that is commonly recognized as aging. Because of this, the cell is constantly challenged to destroy these free radicals before they can inflict any lasting damage. Minimizing oxidative attacks may actually be the ultimate challenge of being alive. Because of this, the reducing power of glutathione is of huge important to the cell.

Glutathione is important for helping to regenerate other antioxidants that are depleted from their constant work to fight off free radical challenges. Regeneration that is glutathione-induced may be the mechanism that is actually used by the cell in order to conserve lipid-phase antioxidants, vitamin A, vitamin E, and the carotenoids. It has been confirmed by recent investigations that dietary vitamin C can actually protect us against tissue damage that results from glutathione depletion.

Additionally, supplementation with glutathione or its precursors can also quickly replenish any vitamin C deficiencies. Because of this, glutathione and ascorbic acid, both of which are pre-eminent cellular antioxidants, are tightly linked, as glutathione can conserve vitamin C and vitamin C can conserve glutathione. When they are both present, these two antioxidants protect the entire spectrum of biomolecules that are found within the cell, as well as facilitate the cell’s best performance. It has been said that the glutathione status of a cell may be the most accurate single indicator of the health of the cell. This means that as glutathione levels go, the health of the cell will go as well.

Glutathione is available in capsule or tablet form at your local or internet health food store. Always choose name brands to ensure quality and purity of the glutathione supplement you choose to purchase for consumption.