DHT - PROSTATE - SAW PALMETTO

Saw Palmetto for treating prostate related problems.	Darrell Miller	05/13/05
Prosta Response -- Supports proper prostate function!	Darrell Miller	05/20/05

Date: May 13, 2005 06:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Saw Palmetto for treating prostate related problems.

SAW PALMETTO BERRY EXTRACT INHIBITS CELL GROWTH AND COX-2 EXPRESSION IN PROSTATIC CANCER CELLS

Cell Biology International 2001, Vol. 25, No. 11, 1117–1124 doi:10.1006/cbir.2001.0779

"Formulations based on Saw Palmetto berry extract (Serenoa repens) (SPBE) have traditionally been used for treating prostate related problems, and clinical research has supported the application of SPBE in the fight against benign prostatic hyperplasia BPH (Wilt et al., 1998; Plosker and Brogden, 1996; DiSilverio et al., 1998; McKinney, 1999; Lowe and Ku, 1996). The combination of this extract with other herbs has been shown to lower not only testosterone concentrations but also the concentration of prostatespecific antigens (DiPaola et al., 1998). Researchers have further demonstrated in animal studies that SPBE inhibits the binding of dihydrotestosterone DHT to its receptor (Carilla et al., 1984; Sultan et al., 1984) and blocks the conversion of testosterone to DHT by inhibiting the activity of 5-- reductase. So far the mechanism of action is not known for this phytotherapy but it may include an anti-oestrogenic, anti-androgenic, anti-spasmolytic, or anti-inflammatory effect, or the inhibition of 5--reductase, since all of these activities have been documented for it in in vitro experiments (Stoner, 1996; Carraro et al., 1996). In the present study, we investigate the role of SPBE in prostate cancer by comparing the growth of prostatic cancer cell lines in the presence and absence of SPBE. The data presented here demonstrate that SPBE inhibits the growth of a normal prostatic derived cell line and two prostatic carcinoma cell lines. The results may suggest an ‘operating mechanism’ involving growth inhibition via alterations in the expression of Bcl-2 and prevention of prostate carcinoma development through the inhibition of expression of Cox-2. "

" [Note: The ‘mechanism of action’ of SPBE is reported to be its ability to inhibit the conversion of testosterone to DHT (Bayne et al., 1999; Iehle et al., 1995; Delos et al., 1994). SPBE also inhibits the binding of DHT to its receptors (Sultan et al., 1984; Carilla et al., 1984). Further, it has been suggested that too much DHT could cause prostate cells to divide at an abnormal rate leading to enlargement of the prostate gland. Other effects of SPBE are anti-inflammatory (Di Silverio et al., 1992) and anti-estrogenic (Di Silverio et al., 1992; Briley et al., 1983). In conclusion, SPBE is a well-tolerated drug that has an efficacy similar to Finasteride in improving symptoms in men with BPH (Plosker and Brogden, 1996; Gerber et al., 1998). An additional effect of SPBE is the inhibition of growth factor-induced proliferation of human prostate cell-cultures (Paubert-Braquet, 1998). This drug also induces a significant reduction in DHT and epidermal growth factor concentrations in human BPH following three months of treatment (Di Silverio, 1998). Amongst other effects suggested for how SPBE functions, is the inhibition of signal transduction through the prolectin receptor (Vacher et al., 1995)]."

Saw Palmetto 320mg Standardized 60sg Vegetarian Formula

Saw Palmetto 320mg Standardized 120sg Vegetarian Formula

Saw Palmetto Berry Extract 60sg

Saw Palmetto Berry Extract 120sg

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Date: May 20, 2005 07:28 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Prosta Response -- Supports proper prostate function!

Prosta Response

Prosta-Response is a Bio-Aligned Formula that supports multiple body systems involved with the health of the prostate - a walnut-sized gland located under the bladder and surrounding the urinary tract in men. Prosta-Response supports hormonal regulation, cellular regeneration, antioxidant defense, the bladder and urinary tract, and the body's natural soothing mechanisms. It contains clinically researched amounts of saw palmetto extract and beta-sitosterol, plus quercetin, soy, and lycopene. These antioxidants and compounds, along with essential vitamins and minerals, help maintain tissue and cell integrity, which are vital to prostate health.