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Beet juice may reduce walking pain with leg artery disease
October 10, 2018 03:26 PM
It may be hard to believe but beet juice is being considered as a way to improve the living conditions of someone with leg artery disease. Some may wonder how this is even remotely possible. However, reports are saying that people who suffer from this disease feel as if beet juice reduces some of the pain when walking. This is a massive revelation because, if true, now doctors and scientists have a sort of remedy for something they did not have before.
"“This makes it an attractive potential therapeutic approach for individuals with PAD who have severely limited blood/oxygen supply to the lower limbs which severely reduces their function and makes everyday tasks require a vigorous effort,” said senior study author Jason David Allen of the University of Virginia in Charlottesville."
Read more: https://www.reuters.com/article/us-health-blood-vessels-legs/beet-juice-may-reduce-walking-pain-with-leg-artery-disease-idUSKCN1LN2JC?feedType=RSS&feedName=healthNews
GLUCOSAMINE: Origin and Action of Mechanism
February 06, 2012 01:08 PM
Glucosamine is an amino sugar made from glucose and amino acid glutamine. It is a monosaccharide that is found naturally in healthy joints, cartilages, ligaments, muscles and tendons. It helps in the formation and repair of cartilage and other body tissues. Glucosamine is available in the form of dietary supplements, cosmetics and sports drinks. Let us find out about the history of glucosamine and its role in repair and treatment of joint disorders.
HISTORY of GLUCOSAMINE:
Glucosamine was first discovered in 1876 by Dr. Georg Ledderhose. It was prepared by hydrolysis of chitin with Hydrochloric acid. Later on it was developed in sulphate blend. Since then, it has been studied multiple times and in multiple ways to find out its potent health benefits. It has been used clinically in Europe since 1960s. In 1971, researcher K. Karzel glucosamine HCl stimulated the production of glycosaminoglycan layer, which helps in protecting cartilages, ligaments and tendons from normal wear and tear. It became popular in United States in the mid 1990s with the publication of popular bestsellers such as 'The Arthritis Cure' by Jason Theodosakis. Now it has become the most popular selling dietary supplement with sales of $200 million per year.
Glucosamine is naturally found in the body and can be synthetically made from the natural sources of chitin that is found in sea creatures such as shells of shell fish, bones and bone marrow.
How does Glucosamine Works in reducing Joint pain?
Our body's ability to produce glucosamine decreases as we age. Hence after any kind of injury cartilage, spinal discs and joints, the body may not be able to heal optimally. Aging and glucosamine depletion in the body leads to joint degradation. However, glucosamine supplementation can support cartilage and CT-integrity limiting degeneration.
Glucosamine supplements do not work like NSAIDS, which are known to have anti-inflammatory and analgesic effects on the body. The exact mechanism of significant analgesic effect of glucosamine supplements is unknown but according to various studies, glucosamine has no effect on cyclooxygenase system. Studies have shown that glucosamine stimulates synthesis of proteoglycan in a dose dependent manner. It helps in stimulating the production of cartilaginous matrix, hence counteracting the degrading loss of cartilage in case of arthritis or injury.
Several important studies demonstrate the role of glucosamine in stabilizing cell membranes, inhibit lysosomal enzymes and reduce the generation of oxygen free radicals by macrophages. It may inhibit interleukin 1 induced nitric oxide activity that leads to chondriotic cell death. Hence it increases aggrecanase activity that helps in preservation of proteoglycan.
Glucosamine along with Chondroitin sulphate stimulates synthesis of cartilage precursors as well as synovial fluid. They also limit the degradation of existing cartilage in any loss of joint integrity.
This non rapid acting drug has many beneficial effects in reducing the symptoms of osteoarthritis. It is a powerful joint repairing supplement that rebuilds joint cartilage. Glucosamine supplements have been thoroughly evaluated to find out any potential side-effects. However, it has been proved that it does not have any of the side-effects of NSAIDS, surgery or opiods.
All Natural Hair Care Products - Salon Quality!
September 01, 2006 01:48 PM
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Jason Fragrance Free: Pure and Natural
Studies indicate that 15-30% of the population reports some sensitivity to fragrance. More than 80% report that exposure to fragrances is bothersome*. Fragrance chemicals can cause health effects, primarily in the skin, lungs and brain.
Jason Fragrance Free is a line of hair and body care products formulated for individuals with fragrance or skin sensitivities and those who just want to steer clear of fragrance, dyes and synthetics. Many “unscented” products mask the odor of the formula with fragrance so they remain a potential source of skin irritation. Synthetic fragrances often contain phthalates which have been linked to birth defects and health related issues.
Unlike “unscented” products-which often contain fragrance to mask the scent of the formula—Jason Fragrance Free is truly sans fragrance. Stock up on Jason Naturals complete product line.
*”scents and Sensitivity,” Environmental Health Perspectives, the research journal of the National Institute of Environmental Health Sciences, www.herc.org, Nov. 1998
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The Joints Are Jumping
June 11, 2005 04:56 PM
The Joints Are Jumping by Rachel Alexander Energy Times, October 8, 2003
It usually starts with a twinge in your back or an ache in your knees: Knee stiffness, back pain and joint inflammation can signal the beginning of arthritis.
According to the US Food and Drug Administration, arthritis affects over 42 million Americans-that's 1 in every 3 adults-and costs the economy nearly $65 billion annually. But as common as arthritis is, it doesn't have to extract a high cost from your joints.
Who's At Risk?
Arthritis literally means an "inflammation of the joints" and can affect anyone-from small children to 80-year-olds. Some groups are more prone to certain types of arthritis; for instance, those over 40 are at greater risk for developing osteoarthritis, a degenerative condition of the joints.
According to Johns Hopkins Medical Institute, more than 50% of all individuals over the age of 40 have x-ray signs of osteoarthritis in weight-bearing joints (such as those in the knees and hips), and nearly half of those over 65 have measurable symptoms of arthritis. Osteoarthritis is often caused by overuse, age, excess weight or genetics, or by a combination of these factors.
Rheumatoid arthritis, on the other hand, is a disease of the immune system that affects the joints, which can make it harder to diagnose because early symptoms-fatigue, weakness, loss of appetite and low-grade fever-can mimic other chronic conditions.
Stiffness and pain may or may not accompany the initial symptoms of rheumatoid arthritis. However, joints eventually become inflamed and swollen. Although less common that osteoarthritis, rheumatoid arthritis affects more than 2 million Americans.
Covering Up the Signs
Treating arthritis can involve the use of both conventional and non-conventional therapies.
"In osteoarthritis specifically, conventional medicine has just been focused on covering up the symptoms," says Jason Theodosakis, MD, author of The Arthritis Cure (St. Martin's Press). "In the history of medicine, this approach has been considered primitive."
But Dr. Theodosakis points out that treatment often depends on the type of arthritis involved: "Rheumatoid arthritis patients should be taking prescription drugs that are known to prevent the disease from progressing. [Use] alternative medicine as an adjunct..."
Conventional therapies often involve the use of non-steroidal anti-inflammatory (NSAID) medicines, such as ibuprofen and naproxen. The chief drawback of NSAIDs is the toll these treatments extort from the gastrointestinal system.
In fact, a 2002 study conducted by researchers at the University of South Florida, Tampa, found that more than 15% of patients developed digestive problems after a five-week course of ibuprofen. In addition, ibuprofen may increase blood pressure.
Newer prescription NSAIDs called COX-2 inhibitors, which work by suppressing the body's inflammatory response, also carry risks of side effects ranging from diarrhea and fluid retention to liver damage and kidney problems. In addition, people with asthma or chronic allergies (including to aspirin) should not take these medicines.
Corticosteroids-another treatment option that has been used to lessen inflammation-can cause side effects such as increased appetite, mood changes and even immune system breakdown.
A growing body of evidence shows that nutrients such as glucosamine and MSM, coupled with lifestyle changes, can help decrease or eliminate some of the aches and pains of arthritis. Glucosamine is a natural chemical that helps build joints. When the cartilage in joints deteriorates due to age or other factors, studies indicate that glucosamine provides the necessary building blocks for rebuilding and repairing this tissue.
In one investigation (Archives of Internal Medicine 2002; 162:2113-23), scientists discovered that glucosamine slowed the progression of osteoarthritis and improved symptoms for over 200 patients. Another study, conducted by researchers in the Netherlands, demonstrated that a combination of glucosamine and chondroitin holds promise for conditions such as spinal disc degeneration.
To date, several studies have confirmed glucosamine's ability to help the symptoms of arthritis, and the National Institutes of Health is currently supporting research to further study the benefits of glucosamine.
Other Joint Aids
MSM is often an adjunct therapy as it does not work directly on joints, but provides the raw materials, in this case sulfur, to help rebuild cartilage in the joint matrix. Studies indicate that sulfur has a protective effect and may interact with magnesium, an essential bone nutrient.
Traditionally, the herb horsetail (Equisetum arvense) has been used to supply silica, a mineral component of nails, bones and joints. Its support of these structures can help in the fight against arthritis.
As the body ages, it may lose much of its silica reserves. Resupplying much of this mineral may help support joints. In addition, experts believe, silica can help the body use calcium more effectively and support bone health.
Since rheumatoid arthritis is a systemic affliction, you should work with a trained health professional in treating it. Complementary care practitioners often use antioxidant nutrients, such as vitamins C and E, to reduce free radical damage, along with pantothenic acid (vitamin B5) to lessen morning stiffness.
A Joint Project
According to Dr. Theodosakis, exercise is the key to dealing with arthritis: "[Start with] an individualized exercise program that strengthens the joints without causing more damage...and an eating program to control your weight if you are currently overweight." To limit the effects of arthritis, you should quit smoking, since smoking generates free radicals that can harm the tissues which make up joints. In addition, a strict vegan diet may help alleviate some of the pains of rheumatoid arthritis.
Dr. Theodosakis also recommends looking for hidden causes of symptoms, such as food allergies, that may contribute to arthritis.
Heat helps ease arthritis pain and encourages both blood flow and tissue repair. A plain, old-fashioned hot water bottle works quite well. Or you can use one of the newer heat-generating wraps, which are thin enough to be worn under clothing and don't have to be constantly reheated.
You can't always avoid arthritis, especially as you get older. But you don't have to let it get the better of you.
June 10, 2005 05:32 PM
Allergy Alleviation by Cal Orey , February 2, 2002
Allergy Alleviation By Cal Orey
Welcome to the stuffed up world of seasonal allergic rhinitis: the wheezing, sneezing "inhalant allergies" that torment 35 million Americans. Adding insult to sinus pain, other allergens attack year-round. Air pollution, dust mites (microscopic gremlins that infest bedding, upholstery and rugs) and animal dander trigger allergies-or other respiratory ailments-in any season. Urban air is full of rubber tire particles, a true blowout for those with latex sensitivity. Altogether, roughly 50 million Americans-about one in five-suffer from some form of allergy, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Tired of cross-pollinating with plants or being bowled over by dust balls? Vitamins, herbs and other nutrients can help you nip allergy discomfort in the bud.
The Allergy Response
Your immune system triggers an allergic response when it overreacts to otherwise harmless substances or antigens (we're talking dust, pollen and mold).The alarmed immune system then launches a defensive chemical reaction, releasing potent chemicals (antibodies) supposed to destroy the "invaders." The antibodies, called IgE, carry the invading substances to special cells, which zap them with more biochemicals. Among these protective cells are mast cells: they release histamine, the substance that causes swelling and inflammation to the linings of the nose, sinuses and eyelids, resulting in sneezing, upper respiratory congestion and itchy, watery eyes.
Just Blame The Folks
Most allergies are determined by your genes. If your Mom or Dad sneeze and scratch, there's a good chance you will, too. "That is not to say that we directly inherit an allergy to any specific substance. Rather, it seems as if we might inherit some kind of immune system defect or weakness that leaves us more vulnerable to allergies," explain co-authors Glenn S. Rothfeld, MD, and Suzanne LeVert in their book Natural Medicine for Allergies: The Best Alternative Methods for Quick Relief (Rodale). For some people, allergies lurk in food, throwing the immune system into overdrive. "Many natural medicine practitioners believe that a diet high in animal fats will contribute to the development of allergy and asthma, as does a diet high in food additives, such as preservatives and dyes," says Gary McLain, PhD, in his book The Natural Way of Healing: Asthma and Allergies (Dell). Worse, allergies can up the risk of asthma, which afflicts 15 million Americans. Most people afflicted with asthma also suffer allergies: the two are linked, according to the AAAAI. Allergy triggers of asthma include pollen, mold spores and house dust mites. Remember Helen Hunt's asthmatic son in the movie As Good As It Gets? His character endured allergies to dust, and living in New York (and watching his mom date Jack Nicholson) didn't help his immune system. Coughs, ear infections, fevers and visits to hospital emergency rooms curtailed his social life (and limited his close-ups as well). That kind of routine happens in real life, too. (Well, maybe close encounters with Jack N. are not included for most.) But when we breathe substances such as molds, they can induce swelling and inflammation of the bronchial airways which narrow and restrict air flow. This, in turn, causes wheezing and shortness of breath and can trigger an asthma "attack," according to Andrew Engler, MD, who specializes in allergy and asthma in San Mateo, California.
The Nose Knows: Chemical Sensitivities
Imagine a picture-perfect, crisp, clear Saturday morning. You make a final stop on your weekly errand run to the dry cleaner, where you drop off your laundry and spend a moment chatting up the owner. Back in your car, your eyes tear and you feel a bit woozy. Kenneth Bock, MD, and Nellie Sabin, writing in The Road to Immunity: How To Survive and Thrive in a Toxic World (Pocket Books) sense that your reaction could be chemical sensitivity, a difficult to diagnose but, in their opinion, very real malady. (Of course, a clinician can test you for immune responses to certain chemicals.) Reactions to chemicals produce the typical allergic responses: puffy or red-rimmed eyes; swelling; aching or stiff joints and muscles; irritability or dizziness; respiratory inflammations; headaches and the like. Villains include aerosol sprays, tobacco smoke, glues, insecticides and herbicides, household chemicals and fragrances. Identification and avoidance are key, say the authors. Vitamin C, which binds with chemicals, is one of the best nutritional defenses.
Breathing Problems Expand
Americans now freely take lifesaving medicines such as antibiotics and insulin but, in some people, "they have the potential to alter the immune system, which is where allergies begin," says Dr. McLain. (Consult your pharmacist if you have questions about your prescription medication.) We, as a nation, are also eating more chemicals, from the pesticides drenched on plants to the preservatives poured on prepared foods. We're breathing polluted air, which can lead to or exacerbate asthma, and then we choke on recycled air in sealed buildings. And while a century ago you were likely to have spent much of your time close to home, you can now hop on a supersonic plane and be taken to the other side of the globe within a matter of hours. With travel comes exposure to even more exotic allergens that can drive your immune system to distraction.
The All-Natural Gesundheit
Certain allergy-relief nutrients and herbs can help make life more bearable. Here's how they work: n Vitamin C for the lungs. According to experts, when vitamin C is low, asthma is high. Vitamin C carries the major antioxidant load in the airways and therefore contributes mightily to the health of the lungs. A study in the Annals of Allergy (73(1994):89-96) reported that in seven of 11 clinical trials since 1973, vitamin C supplementation provided "significant improvements" in respiratory function and asthma symptoms. n Vitamin E and carotene to suppress allergic reactions. These antioxidants may also help protect the respiratory tract from caustic pollutants. Vitamin E is reputed to be one of the most important nutrients for antioxidant protection in the lungs. In addition, these two substances decrease production of allergy-related compounds called leukotrienes. n Zinc for the immune system. Research shows that a deficiency in this trace mineral can weaken your immune system, setting you up as a target for allergies and infections. (Some vegetarians may not store sufficient amounts of this mineral and should take supplements.) Zinc comes to the body's rescue by taking part in the production of IgA, the gastrointestinal antibody that lines the digestive tract. "When IgA binds to an allergen, it keeps it from being absorbed into the bloodstream and thus from causing an allergic reaction," report Rothfeld and Levert. Also, zinc protects mucous membranes and helps convert beta carotene to vitamin A, another anti-allergy, immune-boosting nutrient. In a study of 100 participants at the Cleveland Clinic Foundation, half took a zinc-based lozenge, while the other half received a dummy preparation. The participants taking zinc experienced a 42% reduction in the duration and severity of their common colds (Annals of Internal Medicine, 7/96). n Quercetin as an antihistamine. A valuable, anti-allergic flavonoid (plant coloring agent that is a powerful antioxidant), quercetin shines as a potent weapon against allergies and asthma. Believed to inhibit histamine release from mast cells and slow the production of other allergy-related compounds, it stabilizes mast cell membranes. Other flavonoid-rich extracts include grape seed, pine bark, green tea and Ginkgo biloba. n Additional helpful nutrients: Vitamin B-12, particularly to combat sensitivity to sulfites (The Nutrition Desk Reference [Keats]); selenium, an antioxidant that breaks down leukotrienes (Clinical Science 77, 1989: 495-500); and magnesium to relax bronchial tissues (Journal of the American Medical Association, 262 : 1210-3).
Herbal Remedies To The Rescue
n Nettles for hay fever relief. Research at the National College of Naturopathic Medicine in Portland, Oregon, showed that 40 of 69 folks suffering from hay fever found moderate to extreme relief from taking freeze-dried stinging nettles (Planta Medica,  44-47). "It is nontoxic, cheap and preferable to antihistamines, which I think are significantly toxic," reports Andrew Weil, MD, in his book Natural Health, Natural Medicine: A Comprehensive Manual for Wellness and Self-Care (Houghton Mifflin). n Cayenne to reduce inflammation. Cayenne, known as hot red pepper, is rich in capsaicin, a potent flavonoid "counter-irritant" that dilates and soothes inflamed nasal and bronchial tissues, according to experts. A bonus: Cayenne also contains a rich amount of antioxidant vitamin C, which can help enhance your immune system. n Echinacea for allergy prevention. This popular Native American herb provides cold and allergy protection, particularly when you take it before encountering allergens. Studies reveal that echinacea aids your body's tissues and protects you from germs and allergens. In fact, German studies have found it possesses valuable antiviral, antibacterial and immunity-boosting properties.
Make Your World Allergy-Free
For the most effective allergy relief, make sure you stay clear of allergens that wreak allergy havoc. Visit an allergy-savvy health practitioner and get tested to find out which substances rock your respiratory world. Plus, allergy experts recommend: n Banish dust mites: sweep out clutter and have your house power-vacuumed, if necessary; wash bedding and linens in very hot water. n De-pollinate your environment: flip on the air conditioner to sift out pollen (keep its filter and any forced air registers clean); exercise indoors; machine dry, rather than line dry, your clothes. n Buy a home air filter, especially if you experience dust, pollen or pet dander allergies. n Avoid allergy triggers that dog your days: cats and canines (or consider the hairless or shed-less breeds), mold and tobacco smoke. No matter what you do or actions you take, allergies may always remain an annoyance in your life. But attention to the foods you eat, the places where you exercise and the right combination of anti-allergy nutrients can limit your discomfort.
Leveling The Leukotrine Playing Field
On a microscopic level, a series of biochemicals implicated in allergic reactions are leukotrienes, substances that may constrict the bronchial tubes (breathing passages). In some people, consuming the food additive tartrazine can cause severe asthmatic breathing difficulties by boosting leukotrine release. In turn, this can interfere with the body's use of vitamin B-6. The process in which lack of B-6 or "errors" in how your body uses B-6 causes allergic reactions and is complex. According to Michael Murray, ND and Joseph Pizzorno, ND in the revised edition of the Encyclopedia of Natural Medicine (Prima), breathing problems may begin when the metabolism of tryptophan (an amino acid) goes awry: "Tryptophan is converted to serotonin, a compound that, among other things, can cause the airways of asthmatics to constrict...Vitamin B-6 is required for the proper metabolism of tryptophan." Accordingly, a study of vitamin B-6, published in the American Journal of Clinical Nutrition, shows that people with compromised breathing may possess less B-6 in their blood than others who breathe normally. When people with asthma were given B-6, their wheezing and asthmatic attacks dropped.
Fat Fix For Allergies
The fat in your diet or supplements can also influence your susceptibility to allergies and asthma linked to allergies. Epidemiologists have found that countries where children eat fish at least four times a month cut their risk of asthma by 67% compared to other parts of the world where they consume fewer fish. Research on omega-3 fatty acids, the kind of fat found in fish, flax and hemp oil, demonstrates that some of these substances can improve breathing. In particular, fatty acids called eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can help open up bronchial tubes. Studies in the American Review of Respiratory Disease and the International Archives of Allergy and Applied Immunology show that breathing passageways may not react so negatively to the presence of allergens when you eat more fish or take supplements containing these types of fats. Many of the scientists who study the kinds of fats we eat believe that the increase in allergies and asthma in the US during the twentieth century may be due to both increasing air pollution (which irritates our lungs) plus a simultaneous increase in our consumption of what are called omega-6 fatty acids. Omega-6 oils are contained in most of the vegetable oils Americans eat, including sunflower and peanut oils. While experts believe that we would be better off consuming a diet containing about five times as many omega-6 fatty acids as omega-3s, today we eat about 40 times as much omega-6s. The chemistry of how these fats influence our allergy susceptibility is complex. It begins in our cell membranes which consist mostly of fat. When we consume omega-3 fatty acids, in our diet or in supplements, and these fats enter cell membranes, the change in structure cuts the availability of arachidonic acid, a fatty acid your body can make and which is found in meat, eggs and dairy products. Eventually, it is thought that this change in cellular metabolism and reduction in arachidonic acid forces the body to make less 4-series leukotrienes, substances which are quite prone to provoking allergic inflammation and, instead, produce 5-series leukotrienes, leukotrienes which don't cause nearly as much trouble. This process requires patience. According to Pizzorno and Murray. "It may take as long as one year before the benefits are apparent, as it appears to take time to turn over cellular membranes in favor of the omega-3 fatty acids."
Chinese Medicine Versus Allergies
Traditional Chinese Medicine (TCM) views allergies as an imbalance of the liver, says Jason Elias, co-author with Katherine Ketcham of The Five Elements of Self-Healing (Harmony Books). "The average American's (liver) deals with about fourteen pounds of chemicals a year. What would normally be a minor irritant becomes major because the liver can't process them anymore," explains Elias. Licorice root (Glycyrrhiza glabra) has traditionally been used to fight allergies since this herb battles inflammation as evidenced by Japanese research and a study published in the journal Allergy. Much of this anti-allergy action is thought to proceed from licorice's interaction with a biochemical called cortisol, a hormone secreted by the adrenal glands. Cortisol (along with epinephrine, another adrenal hormone) relaxes the muscles controlling airways. By slowing the liver's breakdown of cortisol, licorice prolongs circulation of this hormone which, in turn, can help breathing passages stay clear. In addition, glycyrrhetinic acid, a compound in licorice, slows the body's manufacture of prostaglandins and leukotrienes, substances which exacerbate allergic inflammatory reactions. Ma Huang (Ephedra sinica) has been employed for thousands of years to aid breathing since chemicals in this plant widen breathing passages.
Homeopathic Remedies for Allergy
Homeopathic treatments consist of highly diluted substances designed to coax the body into healing itself. The effectiveness of homeopathy for hayfever has been demonstrated by research published in Lancet performed at the University of Glasgow, Scotland. There, scientists showed that homeopathically-prepared medicines produced statistically significant improvements in allergy sufferers. The appropriate homeopathic remedy for any illness depends on the personality type of the person suffering an allergy. These treatments are among those recommended by Dana Ullman: n Allium cepa: appropriate for burning nasal discharge that grows worse in warm rooms and improves outdoors. Relieves non-burning tearing from eyes, raw feeling in the nose with tingling sensation and violent sneezing. n Nux vomica: used when feeling irritable and chilled, with daytime fluent nasal discharge and night congestion that grows worse indoors. Also for those sensitive to cold and to being uncovered. n Pulsatilla: best for women and children with daytime nasal discharge and night congestion who are gentle, yielding, mild, impressionable and emotional. Used when congestion is worse in warm rooms, hot weather or while lying down.
Food Allergy Conundrum Food allergies can prove to be the toughest allergies to identify and eliminate. Jason Elias believes that people may develop food sensitivities from eating the same foods too often. "If someone has an allergy, I might say 'Let's get you off dairy for three weeks,'" he says, noting that some people have limited their hay fever problems by ceasing to consume dairy products. Many have also found relief by maintaining a food diary, keeping track of which foods are associated with allergy attacks and then eliminating those foods. So the next time you sneeze, don't just reach for your hanky, think back to the meal that you just ate. Your allergy problem may be sitting in your stomach as well as making you sneeze and stuffing your sinuses. Taking these kinds of anti-allergy preventive measures can provide life-enhancing relief that feels like a godsend. That lets you attain your healthy best.
This article included reporting by Judy Pokras.