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Astaxanthin Protects The Eye And More!
November 13, 2013 02:52 PM
Astaxanthin is a carotenoid that is commonly found in the marine environment. It is naturally found in salmon, krill, trout, crayfish, shrimp, crustaceans and yeast. It is the chemical that is responsible for the red color in cooked shellfish and salmon meat. The algae Haematoccus has the richest natural source of astaxanthin.
Astaxanthin can also be produced synthetically, but due to the synthetic product consisting of different steriosmers it is not preferred to be used in some cases.
Unlike beta-carotene it has two more oxygenated groups on each of its ring structure, these additional functional groups make it a highly potent antioxidant and give it a configuration that is more polar than that of other carotenoids. Vitamin E has been known as the strongest antioxidant both in topical use in cosmetics and in internal use, but research has shown that astaxanthin has a greater antioxidant strength than Vitamin E. For example in the quenching of singlet oxygen it has an antioxidant strength five hundred times stronger than Vitamin E.
Unlike many other antioxidants it has the ability of crossing the blood-brain barrier and enter into the eyes, brain and central nervous system (CNS). Most diseases of the CNS and eye are caused by increased generation of free radicals or by a decrease in the ability to remove free radicals from the body. Some of the diseases that are caused by problems with inflammation and oxidation include Glaucoma, Cataracts, and Huntington’s disease. These can be prevented by taking astaxanthin.
It has anti-inflammatory properties that are related to its strong antioxidants properties. It suppresses some of the inflammatory mediators such as, prostaglandin E-2 (PGE-2), tumor necrosis factor –alpha (TNF-a), and nitric oxide. Unlike other anti-inflammatory drugs like acetaminophen that can damage the liver and aspirin that may cause stomach bleeding, astaxanthin doesn’t have any side effects.
In people suffering from rheumatoid arthritis and carpal tunnel syndrome it has the ability of reducing pain. Studies have shown that it is able to reduce pain in rheumatoid arthritis by 40% after 8 weeks of continuous use.
It prevents Ultra Violet induces oxidative stress of the skin and prevents the photo aging of the skin. It prevents UV induced formation of wrinkles and collagen degradation in the skin. It may be applied on the skin or taken orally.
In people participating in sports it eliminates the soreness of joints after exercise, and reduces the pain caused by inflammation. This enables athletes to train harder and as a result increase their endurance, skill, and strength. This is through its ant-inflammatory and ant-oxidant effects in the mitochondria (energy producing organelle).
It strengthens the immune system, research by scientists has shown that it causes increase in production of T cells, stimulates the proliferation of lymphocytes, amplify the cytotoxicity of natural killer cells, decrease damage of DNA, and increases significantly delayed type hypersensitivity syndrome.
It prevents heart disease and reduces the risk of people already suffering from heart disease form getting a stroke or heart attack. It improves the blood lipid profiles by increasing HDL (high density lipoprotein) and decreasing LDL (low density lipoprotein).
The liver main function of the liver and kidney is the detoxification and removal of harmful substances in the body. These activities lead to the formation of free radicals. Astaxanthin being a strong antioxidant helps by destroying these free radicals hence it eliminates their oxidative effects.
As a result of its immune benefits Astaxanthin also has anti-tumor properties and as a result it prevents the development of cancer. Its prevention of cancer is also caused by its antioxidant properties and by it regulating gene expression.
What is Schizandra Fruit Good for?
May 17, 2011 02:57 PM
Schizandra and your Health.
Schizandra fruit refers to the berries of schizandra. It is widely used in China and the plant is considered one of the 50 fundamental herbs in Traditional Chinese Medicine. It is a highly prized ingredient to a health tonic historically prepared for Chinese royalty and nobility. In recent years it has become available to more people across the globe as cultivation increases to meet large-scale productions. Also, herbal supplements that contain extracts of schizandra fruit are becoming popular.
Schisandra chinensis is an indigenous plant species of, as the name suggests, China. However, its native range goes as far north as Asiatic Russia. It is cultivated for its leaves, bark, and berries. The name of the fruit in Chinese translates as “the berry that possesses all five basic flavors,” inasmuch as the Chinese believe it contains organic compounds responsible for its unique taste: salty, sweet, sour, bitter, and spicy. The berries are often dried and made into tea that can be served hot or cold.
Scavenges Reactive Oxygen Species
Reactive oxygen species, or ROS, are natural by-products of cellular respiration, the process of energy metabolism that takes place within each individual cell. These include peroxides, singlet oxygen, and free radicals. ROS can interrupt cellular activities and even damage DNA synthesis, the reason why each cell has its own antioxidant defense. That being said, cells are overwhelmed by ROS as we age.
The process of aging has been tied to the weakening antioxidant defense of cells. Free radicals are also believed to be responsible for the fast progression of many life-threatening diseases, such as cancer. Schizandra fruit is a natural remedy for oxidative stress, the cellular damage brought on by ROS. The berries are rich in antioxidants that help replenish the antioxidant stores of the body.
Displays Hepatoprotective Properties
Schizandra fruit is particularly good for the liver. Practitioners of Chinese herbal medicine believe that its berries rejuvenate the liver, the kidneys, and the circulatory system by washing away the toxins these tissues have amassed over the years. The cleansing properties of juices and tinctures that contain schizandra have been ascribed to the organic compounds naturally occurring in the fruit.
Lignans are a class of polyphenolic substances that occur naturally in nature. Schizandrin, deoxyschizandrin, gomisin, and pregomisin are lignans unique to the schizandra fruit. The antioxidant properties of lignans are well established, but those found in the berries of this plant species have an affinity toward hepatocytes, or liver cells. It protects liver cells from oxidative damage and raises the capacity of liver to deal with drugs and their harmful metabolites during first pass metabolism.
Increases Physical Working Capacity
Schizandra fruit is a symbol for youth in the East, and for good reason. For one, it is an adaptogen that increases tolerance to stress and raises the physical capacity of the human body. It is also an aphrodisiac believed to enhance libido and improve sexual performance. Modern herbalists believe its aphrodisiac effects are attributable to its stress-relieving properties.
You too can experience the health benefits of schizandra by picking up a bottle at your health food store.
Can Lycopene Help with Prostate Problems
May 09, 2011 11:14 AM
Lycopene and The Prostate.
Lycopene is an organic compound often associated with tomatoes. It is almost always touted to prevent prostate cancer, though the scientific community has not come to a conclusion yet. Scientists are nevertheless positive that it is good for the prostate, for it displays antiproliferative effects on prostate cells. Laboratory studies are very promising as it appears to inhibitory effect on tumor growth.
Prostate health has long been tied to consumptions of foods rich in lycopene. It is a carotenoid that is bright red in color, and as such can easily be obtained from brightly colored plant products, such as watermelon, papaya, pink guava, and apricots in addition to tomatoes. Like other carotenoids, it displays antioxidant properties. In fact, it is the most efficient scavenger of singlet oxygen of all antioxidants that are classified as carotenoids.
Reverses Oxidative Damage
There have been numerous studies on lycopene in the past few decades, and many of them have noted its antioxidant potential. It has become common knowledge that lycopene is good for the prostate, but not all people know that the prostate gland is its primary storage in the human body. Indeed lycopene interferes with the health of cells and tissues that make up the prostate gland.
One study that tracked down malignant prostate tissues prior to scheduled surgical removal studied the effects of regular intake of lycopene. It was documented and published that lycopene concentrations in the prostate doubled and the oxidative damage to DNA in prostate tissues decreased, suggesting a dose-related efficiency in the prevention of cellular damage brought on by free radicals and other reactive oxygen species.
Induces Apoptotic Death
High consumptions of lycopene appear to directly counteract with cancer cells and tumor growth, not only in the prostate gland, but also in the lungs, breasts, ovaries, stomach, and cervix. It has also been tied to other disorders of the prostate, such as prostatitis and benign prostatic hyperplasia, or BPH. It has been noted to slow down cell proliferation that leads to the enlargement of the prostate.
More imporatantly, lycopene seems capable of inducing the cellular process called apoptosis, or programmed cell death, in prostate tissues, most notably in carcinoma regions. This is also evidenced by a significant decrease in prostate-specific antigen in the blood, the reason why lycopene has gained the attention of researchers for prostate health, spurring a number of studies in recent years.
Maintains Prostate Health
Lycopene levels in the human body are largely dependent on dietary intake. As a general rule, the higher the intake of lycopene is, the healthier the prostate becomes. First, it neutralizes reactive oxygen species such as singlet oxygen and free radicals. It also inhibits the multiplication of prostate cells, effectively preventing benign prostatic hyperplasia, which is believed to afflict up to 80 percent of the male population. For those suffering from prostate enlargement, it slows the progression of the disease.
If you are, 40 years old or more you should consider taking lycopene as a preventative daily!
Lycopene is More than Just a Tomato Extract!
February 08, 2011 04:38 PM
Lycopene is a naturally occurring antioxidant, and a very powerful one at that. Like beta-carotene, it is a carotenoid, a phytochemical that gives certain plants their orange or bright red pigmentation. While lycopene belongs to a group of carotenoids called carotene, known precursors of vitamin A, it does not get converted into vitamin A inside the human body, which is not a bad thing, inasmuch as lycopene in itself exhibits antioxidant properties that surpass the effects of vitamins.
Tomatoes are very rich in lycopene, and indeed consumptions of tomatoes have been reported to show the antioxidant properties of lycopene. Papayas, pink guavas, and watermelons are also good sources of this compound, but the plant source identified to have the highest concentrations of lycopene is Gac, in English also known as Sweet Gourd, a bright red fruit native to Southeast Asia and largely unknown to the rest of the world. With that, a significant fraction of the total lycopene consumption worldwide is derived from tomatoes.
Reactive Oxygen Species (ROS)
Chemical reactions in the human body that respond to the presence of oxygen are part of a process called oxidation, which takes place everywhere else in nature. These reactions entail a change in the oxidation number of atoms or molecules involved in the movement of electrons between molecules inside the body, giving rise to toxic by-products collectively known as reactive oxygen species.
When cells produce the energy that they use to power their physiological functions, they also produce reactive oxygen species, or ROS, which is now believed to be a key factor in the progression of physical infirmities associated with the aging process of human beings and other mammals. That being said, ROS are actually in the employ of the immune system, and particularly effective against pathogens, which may be invasive extracellular matter or harmful microorganisms.
Every single cell make use of enzymes that change the chemical makeup of unnecessary ROS, which must always be kept in check as they damage cells even at low amounts. These enzymes outmaneuver the damaging activities of ROS, thereby protecting the cells. In spite of that, the human body is known to produce more ROS as we age or during long-standing exposure to stress.
Lycopene versus ROS
One type of ROS is singlet oxygen, a form of oxygen that is highly reactive to free radicals. In fact, singlet oxygen is a known catalyst of free radicals especially when it gets excited at the molecular level. Lycopene is the best known carotenoid to counter the damaging effects of singlet oxygen in the human body, and reported to have antioxidant properties far superior to vitamin E and glutathione.
The good thing about lycopene is that its bioavailability compounds when exposed to heat, so cooking tomatoes actually brings out the goodness of this chemical compound. Lycopene acts against the proliferation of cancer cells in a number of mechanisms, and, to date, there have been innumerable reports in support of the role of lycopene against most known types of cancer.
Have you had your Lycopene today?
Astaxanthin, a Member of the Carotenoid Family, is a Powerful Antioxidant
January 31, 2008 09:00 AM
Astaxanthin is a member of the carotenoid family responsible for the red color of many types of algae. Being a carotenoid, it is a powerful antioxidant and free radical scavenger as well as support proper eye function.
However, such a bland statement belies the true worth of astaxanthin in its fight against free radicals. It is of particular benefit in its ability to absorb the high energy of singlet oxygen, releasing it as heat, and returning the singlet oxygen to its ground neutralized state. Singlet oxygen is a particularly harmful and reactive oxygen species of free radical that is formed in the body as part of our normal metabolism, and that contains a high level of free energy that can be used to oxidize and destroy the cells of your body.
In achieving this, astaxanthin is regarded as one of the most potent plant derived antioxidants known, being up to ten times more active than beta carotene, Lutein or its cousin canthaxanthin. So why are antioxidants so valuable to our biochemistry and what would happen if they did not exist?
Free radicals are thieves that use your body as their operating ground. They operate by stealing an electron from a molecule that comprises part of you, and in some cases when this occurs the cell from which the electron is removed is destroyed. Generally electrons go around in pairs, but occasionally an electron pair can lose one of the electrons during a chemical reaction. Many such reactions occur naturally inside the body, especially during the production of energy from blood sugars in the mitochondria, and such a molecule containing a single unpaired electron is called a free radical. Free radicals are also generated by the reactive components of many pollutants such as traffic fumes and cigarette smoke, tars and pesticides, and also by the effect of UV radiation in sunlight.
The only purpose of a free radical is to steal an electron from the first source it can find. Such reactions occur very rapidly after the free radical has been generated, and if this electron belongs to another body cell, then the cell is destroyed leading to effects such as premature aging or even cancers. Free radical oxidation of the LDL lipids that carry cholesterol around the blood causes the deposition of fatty plaques inside arterial walls that eventually become constricted or even blocked, leading to heart disease or strokes.
That is why antioxidants that destroy these free radicals are so prized, and the more of them that there are in your body then the less affect the free radicals will have on you. You will retain your youthful looks longer, and will be less liable to suffer from heart disease, cancers, circulation problems and conditions such as diabetes. Many abnormal conditions can be laid at the door of free radicals.
The stronger the free radical, the more harm it can do to you and a strong antioxidant such as astaxanthin is a very powerful weapon in your armory against them. Astaxanthin is a member of the oxygenated xanthophylls, and its high level of antioxidant power likely comes from the ketonic and hydroxyl functional groups of the ionone ring structure. It is more polar than most carotenoids, and this is a likely reason for its ability to span the cell membrane layers, with the active groups close to the hydrophilic-hydrophobic interface. They are thus more readily available at the sites where most free radicals tend to be found and provide immediate protection to the cell membrane and also to the intracellular mitochondrial membrane.
Many antioxidants destroy free radicals by donating an electron, and become oxidized themselves. Astaxanthin, however, does not do this, but instead adds the free radicals to its long double bonded chain hence avoiding oxidation and rendering it much more powerful than normal antioxidants. It is unusual among antioxidants in that it is also able to cross the blood-brain barrier, and so reduces oxidative stress that can cause neurological disorders in general, and also problems with eyesight. It can also attach itself to lipoproteins to enable it to be carried throughout the bloodstream, being available anywhere that free radicals are generated. The carotenoid is also active against active oxygen species that are responsible for inflammation.
Another property is its ability to neutralize the oxygenated free radicals formed by the photo-oxidation properties of UVA and UVB radiation. Included in these are the previously mentioned highly reactive singlet oxygen and also triplet oxygen that astaxanthin is able to neutralize without becoming oxidized. In fact reactive oxygen species in general can cause oxidative stress, and they have been thought responsible for many forms of disease and health conditions, and the powerful effect of astaxanthin in targeting many of these has led it to be regarded as highly beneficial to the immune system and to health in general.
Another benefit is the ability of the substance to help prevent the oxidation of high density lipoproteins (HDL) that are responsible for carrying cholesterol in the blood back to the liver for destruction. Free radical oxidation of HDL impairs its ability to transport cholesterol, and so decreasing the level of such free radical oxidation will by definition increase the quantity of good HDL available, and hence reduce the concentration of cholesterol in the blood. Studies have proved this to be the case, and astaxanthin supplements are very beneficial to those suffering from high blood cholesterol levels, and helps protect them from heart disease and strokes.
The substance is naturally available from a wide range of marine sources, such as lobsters (where it was first discovered), shrimp, salmon, trout and in a wide variety of red and green algae. The substance is also used as a red pigment. Carotenoids are essential, meaning that they are not produced in the human body and can only be obtained in our diets.
For that reason, the most convenient way to take it, apart from continually eating shrimp and lobster, is as a supplement. Astaxanthin is available either as a powerful antioxidant in its own right, or in combination with other substances with which it acts to provide a very strong deterrent to any free radicals that think they can freely roam your body.
Neptune Krill Oil - EPA and DHA Rich!
July 02, 2007 12:43 PM
Complete List of Now Vitamins Starting at 40% OFF.The oil of Atlantic Krill, a zooplankton crustacean, contains one of the most unique nutrient profiles ever discovered. In addition to rich concentrations of EPA and DHA, krill also boasts an impressive amount of phospholipids, all-trans retinol vitamin A, natural vitamin E, and omega-9 fatty acids. The oil is an excellent source of esterified astaxanthin—a powerful, immune supporting carotenoid that has been clinically proven to quench singlet oxygen radicals within cell membranes. The potent arrangement of naturally occurring compounds exhibits strong synergist properties that support and protect many of the body’s most vital system.*
At the most basic level, krill oil contains compounds that the body needs in order to construct healthy cell membranes. By nature, omega-3 essential fatty acids can be particularly sensitive to oxidation. Atlantic krill, however, contain antioxidants and Carotenoids that bind to these fatty acids, thus improving the biological stability. Accordingly, studies have shown that as much as 95% - 95% of the EPA and DHA in krill oil is capable of being absorbed for use throughout the body.
Among its most impressive qualities, Neptune Krill Oil contains phospholipids that are rich in EPA and DHA, and structurally similar to those produced by the human brain. The most significant include phosphatidyl Choline, phosphatidyl Inositol, and phosphatidyl ethanolamine. Researchers believe that their unique structure and ability to cross the blood-brain barrier make it possible for those compounds to support brain and cognitive health.* Now Vitamins Neptune Krill Oil is manufactured under the strict quality control, and tested to be free of potentially harmful levels of mercury and other heavy metals, PCB’s, dioxins and other contaminants.
100% Pure Neptune Krill Oil
Astaxanthin - PHYTONUTRIENT ANTIOXIDANT
December 28, 2005 10:20 AM
"PHYTONUTRIENT ANTIOXIDANT" Astaxanthin
Carotenoids are a class of lipid-soluble natural pigments found in plants, as well as in phytoplankton and certain fungi and bacteria. The red, orange and yellow colors seen in fruits and vegetables are from carotenoids. When various aquatic animals such as salmon and shrimp eat plants containing some of the over 700 compounds that make up the carotenoid class, those animals are also decorated with the same brilliant colors. However, carotenoids do more than provide color - they’re powerful phytonutrient antioxidants. Beta carotene, lutein, and lycopene are some of the more well-known carotenoids, but the most powerful found to date is astaxanthin.
Astaxanthin is a fat-soluble carotenoid with a unique molecular structure that makes it an extremely effective antioxidant. The PDR® Medical Dictionary 2nd Edition defines an antioxidant as, “An agent that inhibits oxidation; any of numerous chemical substances, including certain natural body products and nutrients, that can neutralize the oxidant effect of free radicals and other substances.” Not only is astaxanthin a potent free radical scavenger, but it also can protect against oxidation, which limits the number of free radicals produced. Additionally, it’s very effective at quenching a molecule called singlet oxygen, a harmful reactive oxygen species formed through normal biological processes. Singlet oxygen possesses a high amount of excess energy that must be released to keep it from damaging other cells. Astaxanthin absorbs this energy and dissipates it as heat, and in the process returns the singlet oxygen to a grounded state.
A growing body of research is showing that astaxanthin is the creme de la creme of phytonutrient antioxidants. Studies comparing astaxanthin to other carotenoids have shown it to possess antioxidant activity up to 10 times stronger than that of beta carotene, canthaxanthin, lutein and zeaxanthin.4 A study published in 1990 conducted by Kurashige and associates compared the effectiveness of vitamin E and astaxanthin for the prevention of lipid peroxidation. The results showed that astaxanthin is 100-500 times more effective in preventing lipid peroxidation in vivo than vitamin E.5
Astaxanthin in algae provides protection against the effects of ultraviolet (UV) light exposure, and studies are showing that this protective effect is also imparted with dietary astaxanthin. Scientists believe that astaxanthin effectively scavenges the oxygen radicals produced through photo-oxidation caused by UV exposure. A 1995 study by Savoure and associates studied the protective effects of astaxanthin, beta carotene and retinol against UVinduced photo-oxidative stress. The results showed that astaxanthin is extremely effective in preventing increases of certain polyamines created through photo-oxidation, which damages skin. A particular polyamine was found to increase only 1.5-fold in subjects fed astaxanthin, whereas subjects in the control group experienced a significant 4.1- fold increase. It was concluded that astaxanthin works through a particular enzyme, increasing this enzyme’s consumption of polyamines in response to irradiation.
Research has shown that astaxanthin also offers cardioprotective effects through its ability to decrease oxidation of HDL (“good” cholesterol), which is a cholesterol transporter in the blood. It‘s well established that high levels of HDL and low levels of LDL (“bad” cholesterol) are desirable for healthy cardiovascular function, so protecting HDL from oxidation means there’s more circulating in the bloodstream. In a 1992 study by Murillo, subjects were fed dietary astaxanthin for 30 days. HDL cholesterol increased 57mg/dL, compared to the control diet (42.4 mg/dL). LDL cholesterol decreased from 12.5 mg/dL to 9.6 mg/dL. Clearly, astaxanthin exhibited an influence on the ratio of these two lipoproteins.
We can thank the lobster for the discovery of astaxanthin. Researchers working with an extract of the lobster Homarus astacus first characterized astaxanthin in 1938. It was soon discovered that astaxanthin is abundant in nature, although mostly in very low concentrations. The greatest source found is in green algae called Haematococcus pluvialis, which also contains other carotenoids such as beta carotene and lutein. NOW® Foods Astaxanthin supplies 4mg of this effective phytonutrient antioxidant and is an excellent source of this outstanding member of the carotenoid family. The astaxanthin used for our product is BioAstin® supplied by the Cyanotech Corporation, one of the premier suppliers of highquality astaxanthin taken from Haematococcus pluvialis, the richest natural source discovered. In addition to Astaxanthin, NOW® offers other carotenoids, including Lutein, Beta Carotene and Lycopene. Research continues to support the inclusion of carotenoids in the diet to support overall health. This is even truer for those with less than perfect diets and for those who smoke or spend any time with someone who does.
Vitaberry Plus + Super Fruit Antioxidant
December 07, 2005 05:43 PM
Vitaberry Plus +™ Super Fruit AntioxidantBy Nilesh Patel, NOW Quality Assurance, April 20, 2005 Why are FRUITS AND VEGETABLES important? “Diets rich in FRUITS AND VEGETABLES may reduce the risk of some types of cancer and other chronic diseases.”- National Cancer Institute. OXYGEN AND ANTIOXIDANTS As we all know, “Oxygen is critical to life,” but is itself a double-edged sword. While oxygen is necessary to sustain life and for natural defense against microbes, too much oxygen in our cells can lead to the production of “free radicals” (mitochondrial respiratory chain) or ROS (Reactive Oxygen Species). Free radicals come in many forms - singlet oxygen, hydrogen peroxide, superoxideperoxynitrite, to name a few - but all have one commonality. Each has an unpaired (unbalanced) electron, a situation it remedies by stealing an electron from a stable molecule. This sets off a domino effect of oxidation, a chain reaction that usually ends up damaging cellular integrity and compromising overall health. Nature has a defense system in place to protect these processes in the form of antioxidants. Whether endogenous (produced by the body, such as liver enzymes, SOD, coenzymes and sulfur-containing compounds) or exogenous (obtained through the diet, such as vitamins C & E, bioflavonoids, carotenes, etc.), antioxidants “quench” free radicals by donating an electron to stabilize a molecule, thus controling the chain reaction and stopping the oxidation “domino effect”. ANTIOXIDANT-RICH FOODS Research suggests that eating plenty of foods high in antioxidants helps to slow the processes associated with aging and protect against many chronic diseases. Maximizing one’s antioxidant power will enhance overall health. Fruit and vegetables contain both nutritive and non-nutritive factors that can affect oxidative damage and enzymatic defense and might contribute to redox (antioxidant and prooxidant) actions. A new “6-a-day” study looked into the effects of fruits and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers by The Danish Institute for Food and Veterinary Research in Denmark. The study found that fruits and vegetables increase erythrocyte glutathione peroxidase activity and resistance of plasma lipoproteins to oxidation more efficiently than do the nutritive factors (vitamins and minerals) that the fruits and vegetables are also known to contain. Certain berries, such as blackberries, also contain salicylates, which are also linked to heart health and prevention of atherosclerosis. The protective effects of fruits and vegetables intake on both heart disease death and deaths in general have previously been demonstrated but researchers at the Human Nutrition Research Center on Aging at Tufts University, Boston. Quercetin is an anti-oxidizing flavonoid found in many berries (such as cranberries, bilberries, blueberries, strawberries, etc.) and can prevent CVDs (coronary vascular diseases), according to a recent Finnish study. All these natural plant polyphenols are responsible for the colors of many red and purple berries, fruits, vegetables and flowers. GOVERNMENT GUIDELINES The new federal guidelines released earlier this year by the U.S. Department of Health and Human Services (HHS) and U.S. Department of Agriculture (USDA) recommend eating more fruits and vegetables, combined, than any other food group -- five cups or about 10 servings a day for most adults. The amount of fruits and vegetables recommended has increased for men and women of every age. “Fruits and vegetables are the "good news" story of the new Dietary Guidelines for Americans for food-loving consumers, the industry and America's public health”, stated the Produce for Better Health Foundation (PBH). Eating a variety of colorful phytochemical-rich fruits and vegetables has been associated with lower risk of some chronic diseases such as cancer and heart disease. Many authoritative organizations such as the National Cancer Institute and The American Heart Association recommend getting phytochemicals from whole foods, such as fruits and vegetables, rather than from individual component supplements. The Scottish government is promoting healthy eating through a scheme designed to increase purchasing of fruit and nutritional foods. Scottish health minister Andy Kerr said, "This initiative shows that healthy eating can be good for customers and good for business." Scottish women are said to have the highest rates of death from lung cancer in the world as well as the highest rates in Europe for coronary heart disease. They also have low consumption of fruits and vegetables, shown in studies to help protect against some cancers and benefit heart health. ROS (Reactive Oxygen Species) Free radicals and oxygen free radicals play an important role in the development and progression of many brain disorders such as brain injury, neurodegenerative disease, and Down syndrome. Oxidative stress is an important factor in the etiology and pathogenesis of diabetes & is also linked to other host of degenerative health conditions. Fortunately, antioxidants are available to support the body’s defense and fight disease and aging. Examples of “Fast acting antioxidants” in the body (serum) are: uric acid (polyphenols), ascorbate, bilirubin, vitamin E (the later two are lipid soluble). Examples of “Slow acting antioxidants” are glucose, urea nitrogen etc. In short, free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated as by-products of normal cellular metabolism. Their deleterious effects are minimized in vivo (in the body) by the presence of antioxidant systems. How do Antioxidants work? Antioxidants are substances in plants that help maintain health. Antioxidants protect against damage to cells caused by too many “free oxygen radicals,” which form because of the effects of oxidation. Smoking, sunlight, heavy exercise, and pollution all increase oxidation in the body. Most people would benefit by eating more (five to nine or more servings) fruits and vegetables & colorful plant foods, such as purple, dark green, yellow, orange, blue, and red ones, each day. These have healthful pigments along with antioxidant nutrients such as vitamin C, carotenoids, beta-carotene, lycopene, lutein, zeaxanthin, vitamin E, selenium, flavonoids, and other beneficial substances. There are numerous ways in which these antioxidants affect, but can be explained in two groups: Alpha (a) Effects: This refers to the scavenging or neutralizing of free radicals. These effects do not change the way humans (or animals) feel. There are also no noticeable health, psychological or emotional benefits. While there are no obvious changes, increased total antioxidant intakes are associated with decreased tumor rates, prevention of heart attacks and increased longevity. Beta (ß) Effects: These are the changes on health, psychological or emotional state that you or others will notice. In this case, the antioxidant is affecting metabolic processes (enzymes) with consequent changes in the physical (improvement in joint movements, improved skin condition, tissue damage recovery), emotional (better ability to cope with stress) or psychological state (increased alertness). The ORAC value Because most of the active nutritional components in fruits and vegetables are antioxidants, accurate measurement of antioxidant activity serves as a good indicator of potential health benefit. Scientific opinion runs high that ORAC (Oxygen Radical Absorption Capacity) will eventually become a government standard of reference for overall daily fruits and vegetables intake. ORAC units are a measurement of the ability of food to stop oxidation. It is most generally expressed in terms of Trolox equivalent per gram (µmole Trolox equivalents (TE)/g). POPULATION DATA A survey done by the National Research Council indicates that only 10% of the US population consumes the recommended five servings of fruits and vegetables per day. The equivalent to eating 5 mixed servings of fruits and vegetables per day is about 1,670 ORAC units. Based on scientific evidence it is suggested that daily antioxidant intake should be increased to between 3,000 and 5,000 ORAC units per day, per human subject, in order to reach a significant antioxidant capacity in blood plasma and other tissues. WHAT IS NOW DOING TO HELP? In accord with our mission, “To provide value in products and services that empower people to lead healthier lives,” NOW® Foods is introducing an ALL-FRUIT-DERIVED antioxidant product called VitaBerry Plus +™ Super Fruit Antioxidant Vcaps (vegetarian capsules) (product number #3336). At time of manufacture this product provides an ORAC value of at least 2,500 units per serving from a full-spectrum antioxidant blend of fruits containing phytochemicals and phenolic compounds such as anthocyanins, proanthocyanins, chlorogenic acid, ellagic acid, quinic acid, resveratrol , many organic acids, resveratrol and vitamin C. VitaBerry Plus +™ is formulated with VitaBerry™ Hi-ORAC Fruit Blend [a proprietary blend of fruit extracts & concentrated powders containing Wild Blueberry (Vaccinium angustifolium) extract, Grape (Vitis vinifera) & Grape seed extract, Raspberry (Rubus idaeus) & Raspberry seed extract, Cranberry (Vaccinium macrocarpon), Prune (Prunus domestica), Tart Cherry (Prunus cerasus), Wild Bilberry (Vaccinium myrtillus) extract & Strawberry (Fragaria virginia)], Hi-Active™ Orange (Citrus sinensis) and Pomegranate (Punica granatum) min. 40% ellagic acid fruit extract. One gram of VitaBerry™ Hi-ORAC Fruit Blend provides at least 6,000 ORAC units (i.e., µmole Trolox equivalents (TE)/g). (Also watch for an upcoming antioxidant product from NOW called Enzogenol® (Pinus radiata bark extract from New Zealand) with Rutin (a flavonoid from South American fruit of Dimorphandra mollis) and Grapeseed extract. IS IT EFFECTIVE? Total ORAC value includes both lipophilic and hydrophilic components. VitaBerry Plus +™ contains only water/hydroethanol based extracts and concentrated (100:1 to 125:1) freeze-dried fresh fruit blends, so the lipophilic ORAC value is mere 2-4% of the total ORAC value. Glutathione peroxidase is a selenium-containing enzyme that decreases cell death from brain injuries. It also acts as a critical first-line antioxidant defense on the airway (respiratory) epithelial surface against ROS and RNS (reactive nitrogen species. Genetics research has found that the glutathione S-transferase gene controls the onset of Alzheimer’s, Parkinson’s disease etc. Taking glutathione (GSH) itself as a supplement does not boost cellular glutathione levels, since it breaks down in the digestive tract before it reaches the cells. So glutathione precursor dietary supplements (such as NAC and GliSODin), along with fruits and vegetables, are effective in boosting intracellular levels of GSH. The lungs have a defense system against the ROS oxidants consisting of low molecular weight antioxidants such as GSH and intracellular enzymes such as SOD, catalase and glutathione peroxidase to protect against the toxic effects of oxidants generated within the cells. Some of the primary effects of VitaBerry Plus +™ against the common reactive free-radical species or ROS are as follows: - Superoxide dismutase-SOD (destroys Superoxide radicals),
- Catalase (neutralizes peroxides),
- Functions similar to reduced Glutathione (GSH),
- Glutathione peroxidase enzyme (detoxifies peroxides, using GSH as a reducing agent),
- Functions similar to Glutathione S-transferase (GST),
- Nullifies Superoxide-generating NADH/NADPH oxidase system In conclusion More concentrated than fresh berries, with over 6000 ORAC units per gram, VitaBerry Plus +™ provides consumers with the antioxidant power of almost 15 servings per day of FRUITS AND VEGETABLES ina convenient vegetarian capsule form! VitaBerry™ PLUS +™ (# 3336) provides a powerful, convenient way to supplement diets that do not include sufficient fruit and vegetable antioxidants Selected References: USDA/HHS guidelines report at: etaryguidelines/dga2005/document/
ls.com/proprietary/pdf/VitaberryBrochure.pdf g Kaplan M., Hayek T. , Raz A., Coleman R. and Aviram M. Pomegranate juice supplementation to apolipoprotein E deficient mice with extensive atherosclerosis reduces macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 131: 2082-2089 (2001) Lars O Dragsted et. al., The 6-a-day study:effects if fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. American Journal of Clinical Nutrition, Vol. 79, No. 6, 1060-1072, June 2004 Fuhrman B. and Aviram M. Polyphenols and flavaonoids protects LDL against atherogenic modifications.In: Handbook of Antioxidants Biochemical, Nutritional and Clinical Aspects, 2nd Edition. Cadenas E & Packer L (Eds.) Marcel Dekker, NY(Pub.). 16:303-336 (2001) Wood, Jacqueline, et al. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry 77 (2002) 155-161 Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. Free Radical Research 36 (Supplement 1): 71-72 (2002) Jennifer Schraag, Antioxidants: Nature’s Way of Balancing Life. HSR Health Supplement Retailer, Vol. 11, No. 2, 24-27, February 2005 com/news/printNewsBis.asp?id=58665 com/news/printNewsBis.asp?id=58697
Curcumin - Turmeric Extract
August 19, 2005 12:47 PM
Turmeric- History and Traditional Usage
Native to Southeast Asia, Curcuma longa is a tall
In addition to its
Turmeric is named in
Protects cells and tissues by fighting free radicals.*
Supports joint function*
The numerous beneficial
Animal studies- In vivo protective effects
Through its free radical scavenging
Curcumin exhibits free-radical scavenging ability when
Bioperine-Nature’s Absorption Enhancer
Traditional Ayurvedic herbal
Curcumin is poorly absorbed in the intestinal
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
NEW PRODUCT ANNOUNCEMENT
July 05, 2005 06:29 PM
The Most Comprehensive Antioxidant Formula Available!
Four tablets contain: Vitamin A (as beta-carotene 8,500 IU & palmitate 4,000 IU) 12,500 IU
gamma-Vitamin E Complex 500 mg
Quercetin 100 mg
RENEWAL ANTIOXIDANTS - The Most Comprehensive Antioxidant Formula Available
June 24, 2005 05:34 PM
The average American’s life expectancy has risen dramatically over the last 100 years. Ideally those extra years will be quality ones. High levels of stress and exposure to environmental and dietary toxins can deplete our antioxidant stores, leaving us more susceptible to chronic health challenges. When we are young and healthy the body unleashes its own antioxidants, but as we age this internal antioxidant producing system declines and the body needs help. Free radicals cause oxidative stress, which is a major cause of accelerated aging. Source Naturals presents the science of RENEWAL ANTIOXIDANTS. This Bio-Aligned Formula™ is a significant advancement over other products currently available. No other formula provides the broad range of high potency, established and newly discovered water and fat-soluble antioxidants that RENEWAL ANTIOXIDANTS delivers.
Bio-Aligned Antioxidant Support
RENEWAL ANTIOXIDANTS™ supports multiple body systems with a balanced spectrum of plantioxidants™ (botanical extracts with unparalleled ability to combat free radicals), vitamins and specialty nutrients that have powerful antioxidant properties. Research suggests dietary antioxidants help balance and modulate free radical activity and help maintain structure and function of important components of cells such as lipids, proteins, and DNA.
Oxygen is required by your cells to generate energy, but it also contributes to oxidative stress or free radical damage, which is one of the primary causes of age-related damage to cells and tissues. Free radicals are unpaired electrons that can damage cells and compromise the function of tissues and organs. Antioxidants make free radicals stable by providing them with an additional electron. Unfortunately, now the antioxidant is missing an electron so, ironically, it becomes a free radical, which requires another antioxidant to donate an electron. Because this process starts a cascade of free radicals, scientists strongly recommend a broad range of lipid and water soluble antioxidants to minimize this negative effect. No other antioxidant formula follows the science better than RENEWAL ANTIOXIDANTS to defend against the widest spectrum of destructive free radicals, including peroxyl, hydroxyl, and superoxide radicals, and singlet oxygen.
Antioxidants neutralize destructive free radicals and support cardiovascular health by halting the oxidation of cholesterol. Cholesterol is only harmful to us if it becomes oxidized. Oxidized cholesterol is an unstable molecule that damages arteries. RENEWAL ANTIOXIDANTS contains hearthealthy antioxidants including gamma E and tocotrienols, which are major lipid-soluble antioxidants that help maintain the integrity of cell membranes by preventing lipid oxidation. The formula includes hawthorn berry and grape seed, CoQ10, lycopene and other powerful antioxidants for heart support.
Nourishing the Brain
Antioxidants are critical for brain and nerve tissue because the brain is mostly composed of fats, which are very sensitive to free radical damage. Research has shown that stress can directly set in motion mechanisms that promote aging, which affects brain and nerve tissue. Ginkgo has been shown to increase memory performance and learning capacity as well as improve blood flow. It is also a free radical scavenger. RENEWAL ANTIOXIDANTS also contains DMAE, bilberry, CoQ10, grape seed, lipoic acid, vitamin B-2 and lutein for broad spectrum support.
Powerful antioxidants help minimize stress damage to liver cells and tissues, thereby supporting detoxification. N-acetyl cysteine is a powerful antioxidant. It is also a precursor to glutathione, a critical antioxidant and detoxifying substance produced in the liver. Silymarin is known for supporting the regeneration of the liver. Since the liver is prone to fat incursion, which makes it vulnerable to oxidative damage, the following fat soluble antioxidants provide critical protection: CoQ10, lipoic acid, ascorbyl palmitate, and gamma E.
The immune system is unlike other body systems in that it is not a group of physical structures but a system of complex interactions involving many different organs. White blood cells generate enormous amounts of destructive free radicals in order to kill invading organisms. Vitamin C, a free radical scavenger, is concentrated in these white blood cells at a much higher level than in surrounding fluid. This extends their life and effectiveness by providing them with a built in defense mechanism against their own free radicals. RENEWAL ANTIOXIDANTS provides water and fat-soluble vitamin C (ascorbyl palmitate and ascorbic acid) along with vitamin A, beta carotene, CoQ10, lipoic acid, quercetin, selenium, gamma vitamin E, tocotrienols, zinc and turmeric, for added immune defense.
Skin & Connective Tissue
Skin is rich in lipids, proteins, and DNA, which are extremely sensitive to oxidation. Age-related changes due to oxidation, loss of elastic fibers and thickening of collagen fibers, cause skin to become fragile and less supple. A broad array of antioxidants protects skin and helps maintain its structure and tone. These include beta carotene, vitamin C, vitamin E, grape seed, zinc, amla (Phylanthus emblica), quercetin, DMAE, manganese and myricetin. Amla is a very effective herbal tonic. It is rich in polyphenols and vitamin C.
Eye tissue is particularly prone to the effect of free radicals. Vision involves light being focused through the lens onto the retina. The macula, or center of the retina, receives the most light. However, sunlight is a powerful free radical generator. Lutein, a potent, fatsoluble antioxidant concentrated in the macula, helps maintain the integrity of the macula and the blood vessels that supply the macular region. The eye also has aqueous tissue that is better protected by water-soluble antioxidants, such as bilberry and grape seed. RENEWAL ANTIOXIDANTS provides these ingredients, along with lycopene, zeaxanthin, lipoic acid, vitamin A, beta carotene and ascorbyl palmitate to support healthy eyes.
Mitochondria, the tiny energy factories within the cells, are the major source of free radicals produced by our own bodies. These components of cells produce ATP (the energy molecule) and provide energy for all cellular activity; therefore, antioxidants are crucial to keep the levels of oxidants they produce in check. RENEWAL ANTIOXIDANTS provides the antioxidant power of green tea, lipoic acid, zinc, vitamin B-2, CoQ10 and Mega H-, a source of electron rich hydrogen ions. Coenzyme Q10 is fat-soluble and its primary functions include activity as an antioxidant and as a cofactor in many metabolic pathways, particularly in the production of ATP in oxidative respiration.
DNA, the blueprint for all molecules in the body, can be altered or damaged by oxidation. Protecting DNA is important for optimal health of all cells and tissues. According to invitro research, certain compounds, such as curcumin (from turmeric) and quercetin, can directly protect against strand-breakage and base oxidation. RENEWAL ANTIOXIDANTS contains these ingredients along with rosemary, pomegranate, raspberry, blueberry leaf, and carnosine. In in-vitro studies, L-carnosine reduced glycation, a process in which DNA and protein are damaged by glucose.
Living Longer, Living Better Strategies for Wellness
Taking personal responsibility for your health and exploring safe alternatives to support prevention is the basis for the wellness revolution. Your health food outlet is leading the way with education and quality products to help you take control of your well-being. Source Naturals is pleased to partner with these outlets to bring you the cutting edge nutritional science of RENEWAL ANTIOXIDANTS. Antioxidant protection is a fundamental part of the holistic healing system. Make this profound formula the cornerstone of your anti-aging program today.
Clement, M., Bourre, J. Graded dietary levels of RRR-y-tocopherol induce a marked increase in the concentrations of a- and y-tocopherol in nervous tissues, heart, liver, and muscle of vitamin E-deficient rats. Biochimica et Biophysica Acta 1334 (1991) 173-181. Borgstrom, L. Pharmacokinetics of N-acetylcysteine in Man. Eur J Clin Pharmacol (1986) 31:217-222. Hipkiss, A.R., et al. Carnosine, a protective, antiaging peptide? Int J Biochem & Cell Biol. 30, May 1998, 863-868.
Heart and Blood Vessels Resveratrol, Gamma E, Tocotrienols, Vit C, Hawthorn Berry, Grapeseed, Myricetin, CoQ10, Ginkgo, Beta & Alpha Carotene, Zeaxanthin, Lycopene, Lutein, Astazanthin, Lipoic acid, Green Tea, Bilberry, Ginger, Turmeric, Blueberry Leaf
Brain and Nervous System DMAE, Ginkgo, Carnosine, Bilberry, CoQ10, Grapeseed, Lipoic Acid, Vit B-2, Lutein
Liver Lipoic Acid, N-Acetyl Cysteine, Vit A, B-2,and C, Beta Carotene, Silymarin, CoQ10, Selenium, Zinc, Gamma E, Tocotrienols, Turmeric, Ginger Glutathione, Wheat Sprouts
Immune System Vit A & C, Beta Carotene, CoQ10, Lipoic Acid, Quercetin, Selenium, Gamma E, Tocotrienols, Zinc, Turmeric
Skin & Connective Tissue Beta Carotene, Vit B-2, C & E, Grapeseed, Lutein, Lycopene, Zeaxanthin, Zinc, Amla, Quercetin, Manganese, DMAE
Eyes and Vision Lutein, Beta Carotene, Vit A & C, Bilberry, Lycopene, Zeaxanthin, Lipoic Acid, Quercetin, Gamma E, N-Acetyl Cysteine, Selenium, Zinc
Energy Production and Metabolism Green Tea, Ginger, Mega H-, Ginkgo, CoQ10, Lipoic Acid, Zinc, Vit B-2, Carnosine DNA Protection Turmeric, Quercetin, Rosemary, Grapeseed , Resveratrol, Lycopene, Lutein, Tocotrienols, GliSODin®, Carnosine, Zinc, Manganese, Amla, Pomegranate, Raspberry leaf, Blueberry leaf
VITAMIN A and CAROTENOIDS - What are they good for?
June 09, 2005 09:27 AM
In 1912, Casimir Funk coined the term 'vitamine' to refer to a 'vital factor' he proposed was an essential component present in foods. His conjecture dovetailed with other research, leading to the isolation in the 1930's and 40's of the compounds we now call vitamins.
Vitamins are chemical substances which play a variety of roles in the human body. They are core components of any nutritional supplementation program.
While many people are aware of vitamins as necessary substances for good nutrition, few have a grasp of the extraordinary complexity of the roles they play in our bodies. As you'll see below, vitamins are involved in trillions of biochemical interactions every minute to keep us alive and functioning. For example, B-vitamins are converted into coenzymes which are directly necessary for the production of ATP energy from food, a process that goes on continuously in every cell in the body and which in turn fuels myriad physiological events such as muscle contraction, brain activity or tissue repair.
Source Naturals offers a full line of vitamins in bioactive forms, allowing you to tailor a nutritional supplementation plan to your individual needs.
VITAMIN A and CAROTENOIDS
Vitamin A is a generic term for a class of fat-soluble substances called retinoids, which can either be consumed preformed or synthesized by the liver from plant pigments called carotenoids (see 'Carotenoids', below). An essential nutrient, vitamin A is perhaps best known for its role in vision.
The outer segments of the rods, a type of light-sensitive cell in the retina of the eye, contain a pigment called rhodopsin (or 'visual purple') that mediates vision in dim light. Cone cells mediate color vision via three additional pigments. Both rods and cones are surrounded by pigmented epithelial cells that store vitamin A. Rhodopsin is formed from a protein called opsin and a vitamin A-dependent compound called 11-cis retinal. As light strikes the rods and cones it is absorbed by the pigment molecules, and retinal is split off from opsin. This chemical change allows an electrical impulse to be sent to the optic nerve and thus to the brain. The pigment must then be regenerated from opsin and retinal. Repeated small losses of retinal during this process require a constant replenishment of vitamin A to the eyes.
Vitamin A also plays an extremely important role in epithelial cell differentiation. Cell differentiation is the process by which a cell undergoes a change to a specialized cell type, allowing it to perform particular functions in the body. It is not yet understood precisely how vitamin A is involved in this process. One hypothesis is that it directly affects gene expression through its interaction with chromatin, a complex of DNA, RNA and protein in the cell nucleus. These interactions affect the process of transcription of DNA to messenger RNA, leading to synthesis of a specific group of cellular proteins.
Each one of us carries in our DNA a unique genetic blueprint. This genetic material is the same in every cell of our bodies. It is only because of this mysterious and magical process of differentiation that we have specialized cell types - and therefore eyes, ears, lungs and hearts.
Vitamin A is necessary, either directly or indirectly, for the healthy growth and functioning of many of our tissues and organ systems, including the eyes, the skin, the bones, the reproductive system, and the natural defenses. It is not yet known whether this requirement is due to the role of vitamin A in cell differentiation or whether there are other physiological processes for which vitamin A is essential.
Vitamin A is related to a class of nutrients called carotenoids, including alpha and beta carotene, lycopene and lutein. Carotenoids are botanical pigments whose colors range from red to orange to yellow. Some carotenoids, particularly beta carotene, can be converted into vitamin A predominantly in the intestinal mucosa and to some extent in the liver. Carotenoids are completely non-toxic; their conversion into vitamin A is well-regulated by the body, making them extremely safe sources of this essential nutrient.
In addition to their role as safe sources of vitamin A, carotenoids are powerful nutrients in their own right. Their primary claim to fame is their powerful antioxidant action, particularly against singlet oxygen. Singlet oxygen is an 'excited' ion of oxygen which, while not technically a free radical, is nonetheless highly reactive. It causes 'oxidative' reactions which can impair or destroy membranes, enzymes and DNA. It can also lead to the formation of free radicals which can cause additional damage.
Certain carotenoids such as beta carotene, because of their chemical structure, can neutralize singlet oxygen by absorbing its extra energy and dissipating it throughout the carotenoid molecule, releasing the energy as heat and converting the singlet oxygen back to 'normal' oxygen. One molecule of beta carotene can quench up to 1000 molecules of singlet oxygen.
In addition to their role as singlet oxygen quenchers, carotenes provide antioxidant protection against free radicals as well. In nature, they protect plants from photo-oxidative reactions; in humans, certain carotenoids, notably beta carotene, may help protect the skin from such reactions. Other carotenoids may provide more localized protection to particular organs. Lutein and zeaxanthin, for example, are selectively concentrated in the retina of the eye. Along with vitamins C and E, carotenes are among the most important nutrient antioxidants in the human body.
LYCOPENE - Tomatoes Like You’ve Never Seen Them Before ...
June 03, 2005 10:51 AM
It’s hard to imagine that the ancestor of the beefsteak tomato was a tiny yellow fruit first harvested by the Incas. Tomatoes have come a long way since their origin in the Andes, becoming more popular than any other fruit or vegetable in America. (Botanically, the tomato is really a fruit, despite the Supreme Court’s 1893 ruling that it’s a vegetable.) Today, our appreciation of this dietary staple is entering a new chapter. Modern nutrition science has delved into the biochemistry of the tomato and discovered unique phytonutrients with powerful influences on the human body. Utilizing this research, Source Naturals has introduced a concentrated form of the tomato’s most vital nutritional compound: Lycopene.
Tomatoes and their Healthy Red Color
Lycopene is the pigment that gives tomatoes, watermelons and some grapefruits their healthy red color. Found most abundantly in tomatoes (Lycopersicon esulentum), lycopene is a member of the carotenoid family. This group of phytonutrients are major contributors to the health of the human race. (Phyto is derived from the Greek word for plant.)
Over 500 different carotenoids have been identified by science, and almost 10% of them are found in human blood and tissue. Best known is beta-carotene, whose important benefits have been well-documented. Other familiar phytonutrients include allicin from garlic, and capsaicin from chili peppers. Lycopene, lutein, alpha-carotene and betacarotene are the most abundant of the carotenoids present in human blood and tissues. Human breast milk has been found to contain 19 carotenoids, including lycopene. Like many carotenoids, lycopene has evolved as an integral part of human biochemistry, with many benefits to our well-being. Since mammals cannot synthesize it, lycopene must be obtained from the diet.
Lycopene and Prostate Function
One of the most interesting aspects of the way phytonutrients interact with the human body – beyond their broad spectrum antioxidant activity – is their tendency to be “organ specific.” Different carotenoids have an affinity for different organs in the body! In the case of lycopene, it’s the most plentiful carotenoid in the prostate gland. Studies have explored the link between diets high in lycopene and proper prostate function.
Lycopene Protects Cells
Research has shown that lycopene may protect DNA by its powerful antioxidant activity against singlet oxygen free radicals, dangerous forerunners to cellular damage. Lycopene was found to be the most efficient biological carotenoid to neutralize singlet oxygen – almost 3 times more powerful than beta-carotene. Also, lycopene has a “sparing effect” for beta-carotene: lycopene sacrifices itself to free radicals so that beta-carotene can be reserved for conversion to vitamin A. Lycopene has another ability that has excited further investigation. It increases gap junctional intercellular communication, which is the chemical and electrical coupling between neighboring cells. This enables a healthy exchange of the signals that regulate normal growth – thereby offering a protective influence on cellular reproduction.
Getting the Most From Tomatoes
Until recently, lycopene was not commercially available, and hasn’t been studied as extensively as has beta-carotene. But now, thanks to a unique (non-chemical) proprietary process, lycopene can be obtained from specially bred and cultivated tomato varieties that are rich in lycopene, and very red. Source Naturals LYCOPENE is standardized to 5% lycopene in a base of vegetable oil. It also contains small amounts of other carotenoids, naturally present in tomatoes. While it’s important to continue eating fruits and vegetables, we can also benefit from the fruits of nutritional research. This is especially important since so much of our food supply has become denatured, lacking the traditional nutrition our bodies require. Source Naturals LYCOPENE is a significant step toward reclaiming the nutrients we need to help create a life of health and vitality. Get a taste of the 21st Century – Source Naturals LYCOPENE.
Heart Science - A Five-Tiered Approach to Heart Health ...
June 02, 2005 12:07 PM
Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available.
Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health
Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for
Energy Generators for An Energetic Organ
Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply.
There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently.
CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10
Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound.
Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21
HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells.
B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization.
The Dangers of Oxidized LDL Cholesterol
While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL.
When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse.
The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes.
Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol.
Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits:
The Regulating Trio
Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings.
Artery Lining Protectors
Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6
Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart.
The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care.
Source Naturals HEART SCIENCE™