Search Term: " Synergy "
From Tradition to Science: Herbs and Your Immune System
September 21, 2017 12:14 PM
Using herbs to keep yourself healthy is traditional. It has been done for millennia. It also works on scientific levels if you do it right. Herbs can be very healthy and can give your immune system a much needed boost so your body can fight off bad bacteria. You can take herbal supplements or can just eat the herbs. There are also teas you can make from herbs. These are often delicious and are a good way to get the herbs in.
"Your immune system isn’t a magic switch you can simply flip on with the right supplement says Reisman. Your body has a very symbiotic relationship with the pathogens that challenge your immunity."
Read more: http://wholefoodsmagazine.com/supplements/features-supplements/from-tradition-to-science-herbs-and-your-immune-system/
What is the Vitamin D/Vitamin K Connection?
November 11, 2016 10:09 AM
New research suggest Vitamin K may be far more necessary than originally thought. Our bodies produce Vitamin D through exposure to the sun's rays, as well has consumption of certain foods. Vitamin K assists Vitamin D in handling calcium for out bodies, meaning they are both needed for good health in your bones and teeth. However, many people have trouble getting the right balance of these two.
"Vitamin D is a very important nutrient for proper body function. It is unique in that our skin has the ability to make it from sunlight"
What Are The Health Benefits Of Acai?
October 16, 2013 10:12 AM
The Acai is basically a type of berry that grows on the Acai palm trees, well known to be a natural flora of the Amazon Rainforest. For a long time, it has also been on cultivation in some parts of the Southern and Central America as a foodstuff. These berries are known to have various varieties but there are two distinct types of Acai berries: the ones that remain green upon ripening and the ones that turn into dark purple color upon ripening. Scientific research has it that the ripe-green type has more oil constituents while the ripe-purple variety has less oil but a wider range of antioxidants.
Strengthen The Liver and Kidneys With Leucine
April 27, 2009 02:08 PM
L-leucine is an amino acid that is used by the body to fuel exercise and muscle-building to provide you with that athletic edge that gets you ahead of your opponents. It does so in a number of ways, none of them specifically by the direct generation of energy as such.
It is also an essential amino acid, since it cannot be manufactured by your body and hence must be taken as a supplement or as part of your diet. Foods rich in leucine include nuts, whole wheat products such as wholemeal bread, and brown rice. It is a hydrophobic amino acid, meaning that it does not like water.
It is also one of three essential branched chain amino acids, the other two being L-valine and L-isoleucine, and offers many benefits to athletic performance that shall be discussed below It also helps to preserve the body's stores of glycogen, used as an emergency energy source. Other than these properties, it possesses others, such as the maintenance of the nitrogen balance in the body.
So how does it work to fuel your body while you are exercising? The answer is not as you might think. L-leucine doesn't increase your energy levels as creatine does when it elevates your ATP (adenosine triphosphate) levels. ATP is the molecule of energy that is synthesized in your body cells, and is then converted back to ADP, the diphosphate, with the release of energy in the form of muscular contractions.
This amino acid is what is referred to as a 'limiting' substance, in that the other amino acids cannot do their jobs in your body unless you have sufficient L-leucine in proportion to them. Specifically, you need two parts of L-valine and two parts of L-leucine to one part of L-isoleucine for optimum usage of the food that you eat.
Therefore you cannot just take the supplement without considering how much should be taken to ensure this balance. Excess will be wasted and a deficiency would fail to make proper use of the protein content of your food.
If you suffer from a deficiency, therefore, your body cannot make best use of the protein in your diet to the extent that muscle tissue will not be generated during exercise. In fact it causes catabolism, or the breakdown of muscle tissue, resulting in a loss of performance and possible increase in fatty tissue as opposed to lean muscle. The only way to build muscle is take in sufficient nitrogen in the form of amino acids and protein, along with L-leucine to put that protein to best use.
One of the major properties of L-leucine is in stimulating the synthesis of skeletal muscle tissue and by using a supplement, the protein balance can be positive after a workout. It has been shown that this protein balance is generally negative until specifically L-leucine is consumed.
The way it works is to activate a muscle-generating pathway known as mTOR (mammalian Target of Rapamycin). mTOR is normally activated when the levels of ATP in the muscle cells is high, and when these levels drop then mTOR is deactivated. The activity of mTOR is sensitive to the concentration of L-leucine, and when the concentration of the amino acid in the body rises it informs mTOR that the protein in the diet is sufficient to manufacture skeletal muscle tissue, and so mTOR s activated.
Exactly how this is done is unknown, but is a fact the mTOR depends upon both L-leucine concentration and also ATP levels. This amino acid also decreases catabolism through a number of different mechanisms, one of which involves increasing insulin levels.
In fact, when insulin and L-leucine levels increase at the same time, there is a Synergy that promotes the synthesis of new protein. Not only that, but the response of insulin to the presence of carbohydrates is enhanced, this resulting in an enhancement of your body's metabolism.
The amino acid can also be used to help those suffering from kidney and liver problems because it increases liver protein synthesis. It is therefore a useful adjunct both to diabetics and those suffering from liver and kidney disease.
However, because L-leucine is an essential amino acid with so many important properties, a deficiency can have specific consequences. Catabolism has been stated earlier as one such reaction to a deficiency, and others include decreased energy levels and irregularities in the levels of blood sugar.
Everything about this substance is not good however, and when taken by itself in excess, it can reduce the amount of the other amino acids in the blood, particularly of the other two branched chain amino acids (BCAAs). This in turn upsets the balance of amino acids, and reduces further the ability of the body to produce muscle tissue until a balanced supplement is taken.
Leucine also helps to maintain the nitrogen balance. It is essential for the human body to maintain a positive nitrogen balance, and L-leucine supports this. In fact, one study has demonstrated that after 12 hours infusion with L-leucine, nitrogen balance was improved by as much as 23%.
A supplement alone is not always sufficient to maintain a positive nitrogen balance. It is generally essential that you rest your body for a sufficient length of time to allow protein to be generated. If you don't take the required amount of rest, a surplus of protein could be used to maintain energy levels rather than replace lost protein and maintain a good nitrogen balance.
A positive nitrogen balance is essential for the generation of muscle tissue, such as in bodybuilding for example, since all proteins contain nitrogen and the net nitrogen intake must exceed the excretion rate. Not in gaseous form, of course, but in the intake of amino acids and proteins. The more positive your nitrogen balance is, the faster you will recover after exercise. It is essential for anabolic exercise.
L-leucine, therefore, is a supplement that can help to maintain your current muscle mass while undergoing strenuous exercise, in addition to increasing it while resting. It offers other health benefits, one being helping to maintain clarity of thought in the aged. However, it is for its effect on muscular build-up and the athletic edge that provides that the supplement is most commonly taken.
B Vitamin Complex
June 23, 2008 03:19 PM
The vitamin B supplement you take is a mixture of nutrients that, although they share the same vitamin letter, are in fact distinctly different chemical entities. The reason that they share the same reference letter of the alphabet is that they are all essential water soluble vitamins (Vitamin C being the only other), they frequently work in Synergy with each other and they often come from common sources and have similar properties in the body. They were therefore at one time believed to be just the one chemical entity.
They are essential in that they must form part of our diet because our bodies cannot manufacture these substances from others, and although most share common biochemical and health functions, there is no health function that requires all of them, and none of them can be totally replaced by another.
The B-Vitamin complex that you take can consist of as many as eight different B vitamins, each of which is essential for a healthy body and at one time it was believed that this mixture was only one single vitamin. That is why they are collectively known as vitamin B and were subsequently allocated numbers: it was only later that the individual components were discovered.
These eight are vitamin B-1 (thiamine), vitamin B-2 (riboflavin), vitamin B-3 (niacin), vitamin B-5 (pantothenic acid), vitamin B-6 (pyridoxine), vitamin B-12 (cobalamins), biotin and folic acid (folate). They are found in yeast, liver, tuna, bananas and rice among other sources, and, as with all vitamins, without them life would not be possible. Not all vitamins are found in each of these food sources, and vitamin B-12, for example, is available in nutritional quantities only from animal sources.
Knowing what they are is all very well, but what does your body do with the B vitamin supplement that you take? Before considering that, the reason that a regular supply is important is because of their water solubility. This is a useful property for a vitamin to possess, because it means that they can easily be transported by the body fluids to the tissues where they are needed. The downside, however, is that they are consequently also easily flushed from the body, and your body cannot store any of the B vitamins.
You therefore must have a regular dietary source that can be augmented through supplementation. This is particularly desirable in alcoholics, those on diets to lose weight and vegans who are advised to take a regular vitamin B-12 supplement.
A lack of vitamin B will make you feel tired and lack energy because they play a big part in your body’s metabolism of blood glucose into energy. They also help to maintain a healthy immune system, keep your nervous system in tip-top condition and maintain good healthy skin, hair and muscles. The B complex is also very important in maintaining healthy blood and liver, and each and every component of the mixture has a specific part to play, both on individually and by interaction with others in the B complex.
Rather than examining what your body does with the supplement as a whole, let’s have a look at each component, and what your body does with that. Taking them one at a time, thiamine (B1) helps you to burn carbohydrates to generate energy. It is highly water soluble and must be taken daily. In the form of thiamine pyrophosphate it plays a key part in the metabolism of carbohydrates to energy, and also in the metabolism of certain amino acids. If you rely heavily on a high carbohydrate diet, you will need a good regular supplement of thiamine to be able to convert them to energy.
Vitamin B2 (riboflavin) also plays a part in fat and carbohydrate metabolism and the formation of adenosine triphosphate (ATP), the molecule of energy. It plays a significant part in the health of your skin and a deficiency is associated with mouth ulcers, cracked lips, flaky skin and bloodshot watery eyes. It also activates vitamin B6 and folic acid, one of the cases where the B vitamins work together synergistically.
Vitamin B3, or niacin, is well known to women as a component of some shampoos, and helps to promote health hair. However, this vitamin also takes part in the process of energy creation within your body, and helps to maintain a good muscle tone within the digestive tract. It is also used as a supplement for the treatment of diseases related to high levels of LDL cholesterol and is useful for the treatment of atherosclerosis.
Pantothenic acid is also found as a component of shampoos, so no prizes for guessing one of its functions. Vitamin B-5 plays a significant part in the energy-producing Krebs Cycle, or Citric Acid Cycle, that is used by every cell in your body to generate energy just where it is needed. It is also needed to synthesize acetylcholine, a neurotransmitter needed for good brain function and it helps to reduce stress. Pantothenic acid is also closely involved in the production of cholesterol in your liver: cholesterol is not all bad, and is needed by your body to produce some of the steroid hormones and also vitamin D.
Amino acids are the small units that are used to biosynthesize proteins and ultimately the genes and DNA that determine who you are. The major factor involved in processing these amino acids is Vitamin B6 (pyridoxine), one of the lesser known of the vitamin B complex. It synthesizes and breaks up different amino acids to produce a variety of other compounds, such as the hormones serotonin, melatonin and dopamine.
Deficiencies in these hormones can be very serious, Parkinson’s disease believed to be connected with a dopamine deficiency for example, and other disorders include kidney stones, anemia and many skin complaints. Although deficiency of vitamin B6 is rare, it can occur in alcoholics and those with chronic kidney problems. It is believed that many diets are deficient, however, and a good vitamin B supplement would ensure that this did not occur.
Vitamin B-12 is one where deficiency can occur, particularly in alcoholics and vegans. It is available in sufficient quantities only from meat sources, and a supplement is indicated in anyone with a low meat intake in their diet. It is used by your body for the replication of DNA and to allow the normal activity of your body cells. It also helps to control homocysteine levels in conjunction with vitamin B6 and folic acid: homocysteine is a high-risk amino acid associated with atherosclerosis and cardiovascular disease that can lead to Alzheimer’s disease, heart attacks and strokes.
The seventh, biotin (sometimes referred to as vitamin B7) also takes part in the metabolism of energy, but deficiencies have not been known, and the final known member of the B vitamin complex is folic acid. This is essential for cell growth and the synthesis of RNA and DNA in the body. RNA (Ribonucleic acid) is responsible for the synthesis of proteins in your body, and the well known Deoxy-ribonucleic acid (DNA) holds the genetic information of your body. Folic acid is therefore essential in the growing fetus, and any other cellular system that rapidly regenerates such as blood cells and the various cells of the immune system.
Without folic acid your body would be more susceptible to bacterial and viral attack, and less able to protect you from foreign invaders into your body tissues. Although deficiency is not common, folic acid is present in fresh food only and degrades when stored at room temperature and when cooked. A supplement is therefore advisable during pregnancy to help to prevent neural tube defects.
It is evident that the Vitamin B complex plays many parts in the chemistry of your body, and that a supplement can be of benefit in assuring that there are no deficiencies. A good B complex can be found at your local or internet health food store.
The Awesome Foursome: Coenzyme Q10, D-Ribose, L-Carnitine, and Magnesium
May 18, 2007 01:06 PM
The Awesome Foursome: Coenzyme Q10, L-Carnitine,
The “Awesome Foursome” of Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium helps our hearts metabolize energy more efficiently and protects them from the stress of cardiovascular disease. This powerful combination of nutrients goes directly to the basic biochemistry of cellular energy metabolism. Now let’s take a closer look at how Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium work in Synergy to promote cardiovascular health.
Energy Recycling through the Electron Transport Chain
Coenzyme Q10 is a powerful antioxidant that helps protect the mitochondrial membrane, mitochondrial DNA, and cell walls from free-radical attack. But its most important function in the body is its central role in energy metabolism.
Most – about 90 percent – of the ATP used by cells is recycled as food (fuel) and oxidized in the mitochondria. Fatty acids, carbohydrates, and, occasionally, proteins are carried across the mitochondrial membrane and enter the Krebs’ cycle, moving from step to step and spinning off electrons. These electrons are then handed off to the electron transport chain, where, in the presence of oxygen, the energy from the electrons is captured as a phosphate group is added to ADP to form ATP. This recycling of ATP is called oxidative phosphorylation, and the by-products of these pathways are CO2 and water.
In this fashion, Coenzyme Q10 acts as a gatekeeper of electrons, making sure they are carried to just the right place to pass on their life-giving energy.
What is critical, however, is the simple fact that without Coenzyme Q10 the electron transport chain would totally break down. And since the electron transport chain is (by far!) the largest contributor to cellular energy turnover, its loss would be catastrophic. It is also important to know that there has to be an excess of Coenzyme Q10 in the mitochondria to be maximally effective. Having just enough isn’t sufficient to do the job properly, and having a deficiency seriously affects the mitochondria’s ability to supply the cell with energy.
Cellular stress can cause Coenzyme Q10 deficiency, which places a severe strain on Coenzyme Q10 availability. People with heart disease, hypertension, gingival disease, Parkinson’s disease, and the other disorders we’ve discussed are known to be deficient in Coenzyme Q10. Whether these deficiencies are the cause or the effect of these varied medical problems, the end result is that they sap the life out of their mitochondria and reduce their energy supplies. You see, Coenzyme Q10 cannot function properly if electrons are not coming out of the Krebs’ cycle, and the Krebs’ cycle won’t work without the fuel that’s transported into the mitochondria by L-Carnitine.
Transporting the Cellular Energy Fuel
Fatty acids are the preferred energy fuel for hearts and most other cells in the body. L-Carnitine facilitates the beta oxidation of fatty acids as energy fuel. And since fatty acids are the preferred fuel for energy recycling in cells, this action is critical to cell and tissue function. Unfortunately, L-carnitine is deficient in people with heart disease, peripheral vascular disease, lipid metabolic disorders, mitochondrial disorders, and many other disease syndromes we reviewed earlier. This L-carnitine deficiency disrupts the normal metabolism of fatty acids, reducing available energy supplies and leading to the accumulation of toxic by-products of fatty acid metabolism. L-carnitine supplementation revives fatty acid metabolism and restore normal mitochondrial function. But even this powerful improvement in cellular energy metabolism cannot up for the energy drain that comes from the loss of energy substrates caused by low oxygen delivery to the tissue. Only D-Ribose can do that.
Rebuilding the Cellular Energy Pool
As long as cells and tissues have plenty of oxygen, the pool of energy substrates in the cell remains high. And as long as there is enough L-carnitine and Coenzyme Q10 available, the process of energy utilization and supply can proceed unimpeded. However, the cellular supply of oxygen can be restricted by acute or chronic heart disease, peripheral vascular disease, any number of skeletal – or neuromuscular diseases, or even high-intensity exercise.
When cells are deprived of oxygen the mitochondrial energy turnover becomes inefficient. Remember, oxygen is required to let the oxidative pathway of energy recycling work properly. If the mitochondria are not able to recycle energy efficiently, cellular energy supply cannot keep pace with demand. But the cell has a continuing need for energy so it will use all its ATP stores and then break down the by-product, adenosine diphosphate (ADP), to pull the remaining energy out of this compound as well. What’s left is adenosine menophosphate (AMP). Since a growing concentration of AMP is incompatible with sustained cellular function it’s quickly broken apart and the by-products are washed out of the cell. The net result of this process is a depletion of the cellular pool of energy substrates. When the by-products of AMP catabolism are washed out of the cell, they are lost forever. It takes a long time to replace these lost energy substrates even if the cell is fully perfused with oxygen again.
Ribose is the only compound used by the body to refill this energy pool. Every cell in the body has the capacity to make ribose, but hearts, muscles, and most other tissues lack the metabolic machinery to make ribose quickly when the cells are stressed by oxygen depletion or metabolic insufficiency. Ribose is made naturally in the cells from glucose. In stressed cells, however, glucose is preferentially metabolized for the energy turnover and is not available for ribose synthesis. So when energy pools are drained from stressed cells, the cells must first wait for the slow process of ribose synthesis before they can begin to replace their lost energy stores.
Acute ischemia, like that which takes place during a heart attack, heart surgery, or angioplasty, drains the cell of energy. Even when oxygenated blood flow returns, refilling the energy pool may take ten or more days. But when oxygen deprivation is chronic, or when energy metabolism is disrupted by disease, there may be so much continual strain on the energy supply that the pool can ever refill without the assistance of supplemental ribose. Conditions like ischemic heart disease or congestive heart failure fall into this category. In these situations, supplementing the tissue with exogenous ribose is the only way the cell can keep up with the energy drain.
Switching on the Energy Enzymes
Magnesium is an essential mineral that's critical for energy requiring processes, in protein synthesis, membrane integrity, nervous tissue conduction, neuromuscular excitation, muscle contraction, hormone secretion, maintenance of vascular tone, and in intermediary metabolism. Deficiency may lead to changes in neuromuscular, cardiovascular, immune, and hormonal function; Impaired energy metabolism; and reduced capacity for physical work. Magnesium deficiency is now considered to contribute to many diseases, and the role for magnesium as a therapeutic agent is expanding.
Magnesium deficiency reduces the activity of important enzymes used in energy metabolism. Unless we have adequate levels of magnesium in our cells, the cellular processes of energy metabolism cannot function. Small changes in magnesium levels can have a substantial effect on heart and blood vessel function. While magnesium is found in most foods - particularly vegetables - deficiencies are increasing. Softened water and a trend toward lower vegetable consumption are the culprits contributing to these rising deficiencies.
Supporting the Links in The Energy Cycle Chain – the Synergy
Clearly, each membrane of the “Awesome Foursome” is fundamental to cellular energy metabolism in its own right. Each plays a unique and vital role in supplying the heart with the energy it needs to preserve its contractile force. Each is independently effective in helping hearts work through the stress of disease. And while each contributes immeasurable to the energy health of the cell, in combination they are unbeatable. Allow me to reiterate the step-by-step, complicated cellular processes involved to be sure that you really understand the rationale for using these nutrients.
The cell needs a large, sustained, and healthy pool of energy to fuel all its metabolic functions. Contraction, relaxation, maintenance of cellular ion balance, and synthesis of macromolecules, like proteins, all require a high energy charge to carry their reactions to completion. The energy pool must be preserved, or these fundamental cellular functions will become inefficient or will cease to operate altogether. To keep the pool vibrant and healthy, the cell needs ribose. But even with supplemental ribose, the cell needs the efficient turnover of its energy stores to balance ongoing energy utilization with supply. That’s where CoQ10 and L-carnitine come into play.
The converse is also true. Even if the cell is fully charged with energy, cellular energy supply will not keep pace with demand if the mitochondria are not functioning properly. CoQ10 and L-carnitine work to keep mitochondrial operations running at peak efficiency, and one side cannot work effectively without the other. Even though CoQ10 and L-carnitine can make the energy turnover mechanisms work more efficiently, they cannot increase the cell’s chemical driving force, and their action will be only partially effective. Ribose on the other hand, can keep the energy pool supplied with substrate, but the value of energy pool repletion cannot be fully realized if the substrate cannot be maximally utilized and recycled. Ribose fills the tank; CoQ10 an L-carnitine help the engine run properly.
Magnesium is the glue that holds energy metabolism together. By turning on the enzymes that drive the metabolic reactions, magnesium allows it all to happen.
These four nutrients must be utilized by cardiologists and other physicians as they treat patients day-to-day. On my own journey, using Coenzymes Q10 for two decades, L-carnitine for more than ten years, D-Ribose for two years, and magnesium equally as long, I’ve seen this “Awesome Foursome” reduce suffering and improve the quality of life for thousands of patients.
The future of nutrition in conventional medicine is very bright, although the integration of nutritional supplements has been a slow and, at times, lonely process.
L-carnitine and Coenzyme Q10 are finally gaining the recognition they deserve. D-Ribose is emerging as a new player in the complex understanding of metabolic cardiology, and doctors are beginning to discuss the important role of magnesium deficiency in heart patients. As a practicing cardiologist for over thirty years, I see metabolic cardiology as the future for the treatment of heart disease and other complex disease conditions, as well.
Benefits of Best Alpha Lipoic 35!
February 12, 2006 03:11 PM
Omega-3’s Fight Postpartum depression
January 23, 2006 02:42 PM
Omega-3’s Fight Postpartum depression
Tucson, AZ—Marine-sourced omega-3 essential fatty acids (N-3 EFAs) combat postpartum depression (PPD), according to a study published online in acta Psychiatrica Scandinavia (www.blackwell-Synergy.com).
In the eight-week trial, test subjects were randomized to receive 0.5 g/d (n-6), 1.4 g/d (N-3) or 2.8 g/d (n-7) n-3 EFAs (as EPAX omega-3 oil provided by Epax AS, Previously a division of Pronova Biocare AS [www.provona.com]). All groups had reductions in mean scores on Edinburgh Postnatal and Hamilton Rating depression scales (51.5 percent and 48.8 percent, respectively); changes from baseline were significant within each group and when combining groups. The researchers concluded results of the study support further study of n-3 fatty acids as a treatment for PPD.
“Omega-3 fatty acids were assessed in a double-blind dose-ranging trial,” said Marlene Freeman, M.D., director of the Women’s Mental Health Program and assistant professor of Psychiatry, Obstetrics & Gynecology, and Nutritional Sciences at the University of Arizona College of Medicine. “A combination of omega-3 EPA and DHA fatty acids provided by EPAX AS was utilized. Among all three doses, patients with postpartum depression improved substantially during the trial. Scores on depression measures decreased by approximately 50 percent and differences were statistically significant.”
RESILIENCE RESCUE ™ SKIN CREAM
December 19, 2005 09:13 AM
RESILIENCE RESCUE™ SKIN CREAM
Resilience Rescue™ Hyaluronic Skin Cream - Resilience Rescue™ helps restore the supple elasticity of youthful, healthy skin. A unique pairing of natural nut butters and hyaluronic acid team-up to reclaim the natural moistures and elastin levels that each one of is born with. But this premium formula does more than just moisturize; it penetrates deep below the skin’s surface to deliver the nutrients needed to reignite a healthy, youthful glow. To further promote anti-aging Synergy, Resilience Rescue™ also contains MSM
Benefits of Alpha Lipoic Acid
October 13, 2005 05:08 PM
Benefits of Alpha Lipoic Acid
Alpha-lipoic Acid––the "Ideal Antioxidant"
The antioxidant potential of a substance is based on a number of criteria, including:
The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes.
As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3
DHLA-regenerates vitamin C, vitamin E and glutathione
Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.
DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7
Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10
1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50.
2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63.
3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31.
4. Serbinova, E. Maitra, I., Packer, L. The Synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21.
5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561.
6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637.
7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87.
8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4.
9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14.
10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804.
SYTRINOL - For Heart Health, Don’t Be Confused About Cholesterol...
June 29, 2005 09:44 AM
SYTRINOL - For Heart Health, Don’t Be Confused About Cholesterol...
Maintaining your cardiovascular health is one of the best ways you can stay fit. That means working to keep your cholesterol levels within the normal range. And contrary to popular belief, the amount of cholesterol you consume in food is not the most important factor for regulating normal cholesterol levels. It is actually the liver’s imbalanced production of cholesterol that is much more critical for your cardiovascular health.
You can address the root cause of maintaining normal cholesterol levels today with Source Naturals SYTRINOL™. This patented blend of citrus polymethoxylated flavones and tocotrienols has been clinically shown to promote cardiovascular health by supporting normal cholesterol production by your liver, promoting balanced triglyceride (fat) production, and providing antioxidant protection. Source Naturals, an industry leader in many categories, introduces the science of SYTRINOL™ in the CHOLESTEROL RESCUE™ product family to support your better heart health today.
The Truth About Cholesterol
Cholesterol is a very confusing subject – our bodies require it but we can also get too much of it. Cholesterol is one type of the ring-shaped compounds called sterols. Other sterols include bile acids, sex hormones, adrenal hormones and vitamin D. Approximately 90% of the cholesterol in your body is in your cell membranes. The remaining 10% can be found in your blood and throughout your body.
Liver’s Over-Production of Cholesterol
When your body needs more cholesterol, your liver takes carbohydrates, proteins and fats (also called triglycerides) from your diet and converts them into cholesterol. The amount of cholesterol that you might consume from foods (in animal products such as eggs, milk, cheese and beef ) is minute compared to the amount of cholesterol produced by your liver. Thus, cholesterol from food isn’t as critical to your total cholesterol. But balancing the cholesterol produced by your liver is very critical to your total cholesterol and thus, your cardiovascular health.
Oxidized LDL Cholesterol
Despite the confusion, cholesterol is a vital component of good health that strengthens cell membranes and provides building blocks for hormones, bile and vitamin D production. However, there is one potential pathway where cholesterol can contribute to an imbalance. When cholesterol moves through the blood to individual cells, it can travel in groups such as lipoproteins, which also contain fats and proteins. When the cholesterol is moving through your blood in Low Density Lipoproteins (LDL) it can undergo oxidation by free radicals in the artery walls. Some medical experts theorize that the oxidized LDL cholesterol becomes trapped in the artery walls as imbalanced deposits instead of completing the journey to join cell membranes. These deposits can eventually reduce the size and function of the arteries, compromising blood flow. Thus, antioxidant protection, balanced triglyceride production, and normal cholesterol production by the liver can all be critically important to your good health. And SYTRINOL™ provides all of these benefits.
How SYTRINOL™ Supports Heart Health
SYTRINOL is a powerful scientifically formulated blend protected by U.S. patent numbers 6,251,400, 09/ 481724. It contains natural citrus polymethoxylated flavones (PMFs) and tocotrienols that go deep to address the root causes of cholesterol wellness.
Polymethoxylated flavones are types of polyphenolic compounds called flavonoids, which are the largest known category of phytonutrients. Health benefits of various flavonoids include antioxidant activity, immune system support, and cellular protection. The unique structure of polymethoxylated flavones, which naturally contain methyl groups paired with oxygen in key places, enables PMFs to interfere with cholesterol production. The citrus PMFs in SYTRINOL, such as tangeretin and sinensetin, promote normal cholesterol levels by inhibiting both the production of cholesterol precursors, such as cholesteryl esters, and the activity of HMG CoA Reductase, an enzyme that synthesizes cholesterol in the liver. These PMFs can also balance the body’s production of triglycerides by inhibiting the activity of your liver’s triglyceride producing enzyme, diacylglycerol acetyltransferase. Since LDL cholesterol is made from cholesterol and triglycerides, decreasing your liver’s production of triglycerides will reduce the amount of those triglycerides available to form LDL cholesterol compounds.
Tocotrienols are compounds similar to vitamin E in structure and function. The tocotrienols in SYTRINOL increase degradation of cholesterol building blocks such as Apolipoprotein B, interfere with cholesterol production, and provide antioxidant protection. The tocotrienols in SYTRINOL are also especially protective antioxidants for LDL cholesterol compounds that have already been produced, helping to prevent the oxidized LDL cholesterol conditions that may affect your cardiovascular circulation.
SYTRINOL’s Proactive Synergy
SYTRINOL works so well because this natural blend of PMFs and tocotrienols works proactively, synergistically, and independently. In preliminary human research, SYTRINOL proactively supported balanced cholesterol and triglyceride production by the liver through the synergistic effects of the PMFs and tocotrienols. Furthermore, SYTRINOL promotes LDL cholesterol antioxidant protection.
The above information has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Other products work reactively to disable existing cholesterol and may only work in conjunction with diets. And because SYTRINOL works independently of diet, you can take it anytime.
Three Lifestyle Strategies for Cardiovascular Health
1. Exercise regularly to increase hearthealthy HDL cholesterol and lower blood triglycerides (fats).
2. Eat a healthy diet rich in fruits, vegetables, whole grains, and lean proteins to help maintain normal cholesterol and triglyceride levels.
3. Take the right supplements to promote your cardiovascular health. In preliminary clinical studies, the amino acid L-ARGININE supported healthy blood flow to the heart and body. GARLIC OIL helps to maintain healthy cholesterol levels and promotes healthy circulation. POLICOSANOL CHOLESTEROL COMPLEX, CHOLESRESPONSE™, CHOLESFIBER™, CHOLESTREX®, and GRAPEFRUIT PECTIN all help to support normal cholesterol levels. HEART RESPONSE™ and HEART SCIENCE™ are advanced formulas that address heart health. Additionally, you can get cardiovascular system supporting compounds such as folic acid, betacarotene, CoQ10, lipoic acid, ginkgo, grapeseed extract, hawthorn extract, magnesium, vitamin E, and many other nutrients in LIFE FORCE MULTIPLE™, Source Naturals’ best-selling multiple. There is a revolution underway in natural health consciousness, and your local health food store is at the forefront. You can benefit right now – long before word spreads to the general public – with the innovative heart nutrition of SYTRINOL, a CHOLESTEROL RESCUE™ product. SYTRINOL™ is a trademark of KGK Synergize exclusively licensed worldwide to SourceOne Global Partners.
PADMA BASIC: A Tibetan Herbal Formula
June 21, 2005 05:27 PM
By Isaac Eliaz, M.D.
"As an integrated system of health care, Tibetan medicine can offer allopathic medicine a different perspective on health. However, like other scientific systems, it must be understood in its own terms, as well as in the context of objective investigation. In practice it can also offer Western people another approach to achieving happiness through health and balance." --His Holiness the Dalai Lama, May 16, 1997
In this article I want to discuss a Tibetan-based herbal formula that reflects the philosophy outlined by H.H. the Dalai Lama. PADMA BASIC® is an extensively researched formulation that bridges the gap between Classical Tibetan Medicine and the modern Western medical paradigm. With over 50 published scientific papers spanning the last 30 years, PADMA's popularity among Western medical professionals can be attributed to its history of safe use and its health-enhancing properties. The original formula, used for centuries as a cardiovascular tonic and to counteract "heat" (inflammatory processes or infections), made its way to Europe by the first half of the 20th century. Acceptance of an ancient Tibetan formula into the Western medical tradition requires sensitivity to both the original Tibetan intention, and the rigorous requirements of the international pharmaceutical community. Today PADMA BASIC is produced in accordance with strict manufacturing guidelines. The herbs are grown organically, or meticulously tested to ensure they are not contaminated. Ingredients are verified using thin layer or high pressure liquid chromatography. While the highest "scientific Western methods" are used, traditional Tibetan "scientific methods" of smelling and tasting are also followed.
PADMA BASIC can be understood from two viewpoints. In Classical Tibetan Medicine, good health means maintaining a dynamic equilibrium of universal elemental forces. Illness is a manifestation of imbalance. Therapeutic intervention aims at restoring balance by treating the cause, not just the symptoms. Within this traditional model, PADMA has three functions:
Ingredients: Iceland moss (Cetraria islandica), Costus root, neem fruit (Azadirachtaindica), Cardamom fruit, Red Saunders heart wood (Pterocarpus santalinus), chebulic myrobalan fruit (Terminalia chebula), Allspice fruit, bael tree fruit (Aegle marmelos), Calcium Sulfate, Columbine aerial part (Aquilegia vulgaris), English Plantain aerial part, Licorice root, Knotweed aerial part (Polygonum aviculare), Golden cinquefoil aerial part (Potentilla aurea), Clove flower, Spiked ginger lily rhizome (Hedychium spicatum), Valerian root, Lettuce leaf (Lactuca sativa), Calendula flower, Natural Camphor (Cinnammum camphora).
Dr. Isaac Eliaz is a medical doctor and licensed acupuncturist with extensive training in complementary modalities. For 15 years, his practice has centered on the integrative treatment of cancer. He has been involved in numerous studies investigating the effects of nutritional supplements on cancer and has been granted two patents.
OptiZinc - The king of Zinc ...
June 04, 2005 10:43 AM
Source Naturals brings you yet another breakthrough in mineral nutrition: OptiZinc! Opti Zinc is Zinc Monomethionine — Zinc combined with the essential amino acid Methionine. It is FDA approved as safe for human nutrition, and is so unique, it’s patented.
Opti Zinc — THE MOST POTENT FORM OF ZINC AVAILABLE Extensive scientific research shows that Opti Zinc is the most bioavailable and bioactive form of Zinc tested.1 Aside from demonstrating superior absorption and utilization by the body for Zinc’s many functions, Opti zinc is also more efficient than other forms of Zinc in getting needed Vitamin A out of storage in the liver, thus making it available for use.2 Perhaps most outstanding is the Synergy offered by this combination of Zinc and Methionine: while both of these nutrients are well-known for their freeradical- neutralizing properties, the antioxidant activity of Opti Zinc far surpasses that of either Zinc or Methionine alone. ZINC — ESSENTIAL
FOR YOUR HEALTH
Zinc is one of the most important minerals your body uses. Among its many functions, Zinc is: ? critical for the health of the thymus gland, which is necessary for the natural defenses, as demonstrated in recent research by Nicola Fabris, Ph.D., director of the Gerontology Research Department of the Italian National Research Center on Aging in Ancona, Italy;3
DO YOU GET ENOUGH ZINC IN YOUR DIET?
As vital as Zinc is, it can be hard to get enough of, even when following a healthy diet. Surveys show that the daily intake of Zinc in the average American diet ranges from 8 to 11 mg, yet the U.S. RDA is 15 mg. The few excellent sources include seafoods (such as oysters, herring, and clams), whole oatmeal, wheat germ, wheat bran, and milk.4 If some of these are not a regular part of your diet, you may be one of many people who are Zinc deficient, and you may want to use a dietary supplement.
SOURCE NATURALS™ — Opti Zinc THE SUPPLEMENT OF CHOICE One Source Naturals’ Opti Zinc tablet provides 30 mg of Zinc (from 150 mg Opti Zinc Zinc Monomethionine), which is 200% of the U.S. RDA for Zinc. 300 mcg of the essential mineral Copper is also included, to offset the displacement of Copper that can occur when high levels of Zinc are consumed. The form of Copper used is also state-of-the-art: it is Copper Sebacate, a natural compound that is Copper:SOD-mimetic, meaning that even on its own, it can act as an antioxidant. Its inclusion with Zinc Monomethionine makes Source Naturals’ OptiZinc a powerful antioxidant combination that is truly on the cutting edge of nutrition science.
OPTI ZINC® brand of Zinc Monomethionine complex is a trademark of InterHealth Company; U.S. Patents Nos. 3,941,818, 4,021,569, & 4,764,633. Source Naturals’ OPTI ZINC® is all-Vegetarian and hypoallergenic: contains no yeast, dairy, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.