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The Health Benefits of Calcium, Magnesium, and Zinc Darrell Miller 5/18/23
Amino acid arginine found to be crucial to mental health; lowlevels contribute to oxidative stress and inflammation VitaNet, LLC Staff 10/1/18
Health Watch: What Do You Know About Vitamin K? Darrell Miller 12/30/17
Probiotics: Research Beyond the Belly...and to the Brain and Heart) Darrell Miller 6/13/17
Health Benefits Of Black Sesame Seed Oil | Health Tips Education Darrell Miller 2/4/17
HEALTHY BENEFITS OF ALMOND FLOUR Darrell Miller 1/28/14
Omega-3 Fish Oil Darrell Miller 5/2/08
Fruit and Vegetable Lightning drink mixes from Natures Plus Darrell Miller 2/6/07
Your emotions, your thoughts may effect your health... Darrell Miller 8/9/05
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease Darrell Miller 6/9/05
Glycerylphosphorylcholine -- Supports Cognitive Function in AD ... Darrell Miller 5/24/05




The Health Benefits of Calcium, Magnesium, and Zinc
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Date: May 18, 2023 05:01 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Health Benefits of Calcium, Magnesium, and Zinc

Calcium, magnesium, and zinc are vital minerals that play a crucial role in maintaining good health. Each of these minerals are essential for various bodily functions and plays a critical role in promoting overall physical wellbeing. While some may know a few of the benefits of these minerals, it's important to understand how each of them contributes to better health and why they should be included in your diet.

Calcium is an important mineral that is necessary for strong bones and teeth. Without it, the body is likely to suffer from conditions such as osteoporosis, a disease where bones become fragile and brittle. However, calcium is not just important for bone health; it also plays a significant role in nerve impulse transmission and muscle contraction, helping to ensure proper functioning of the nervous system and muscular system. Calcium can also help reduce the risk of developing conditions such as high blood pressure, heart disease, and type 2 diabetes.

Magnesium is another important mineral that is often referred to as the forgotten mineral. This is because people tend to focus more on other minerals such as calcium and iron and ignore magnesium. However, magnesium plays a vital role in several bodily functions. It is a component of bones and teeth and participates in numerous enzymatic reactions in the body. Magnesium is intended to provide normal, healthy heart, muscle, nerve, and circulatory function. It can also help reduce the risk of developing conditions such as stroke, heart disease, and osteoporosis. Seventy percent of the population are deficient in magnesium.

Zinc is just as important a mineral as the ones listed above, zinc plays a critical role in overall physical wellbeing. It is involved in over 100 enzymatic reactions in the body, making it an essential mineral. Zinc plays an important role in immune system function, and it is vital for the normal structure of cell membranes. Zinc can also help reduce the risk of developing conditions such as age-related macular degeneration, which can cause vision loss, and can also reduce the chances of suffering from the common cold.

It's important to note that calcium, magnesium, and zinc work synergistically together. For instance, calcium combined with magnesium can help reduce the risk of developing osteoporosis. Similarly, zinc combined with calcium and vitamin D can help improve bone density and enhance the effectiveness of the immune system. These minerals can be found in several foods such as dairy products, leafy green vegetables, nuts, seeds, whole grains, and legumes. However, it can be challenging to get all the necessary minerals from diet alone, which is why supplements may be necessary.

In Summary, calcium, magnesium, and zinc are essential minerals that play crucial roles in our body. These minerals help the body maintain strong bones and teeth, reducing the risk of developing various conditions such as heart disease and osteoporosis, improving immune system function, and enhancing muscular and nervous system function. Taking a supplement can ensure one is obtaining enough of these important minerals daily. Grab a bottle today and take steps to better your health.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6575)


Amino acid arginine found to be crucial to mental health; lowlevels contribute to oxidative stress and inflammation
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Date: October 01, 2018 09:52 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Amino acid arginine found to be crucial to mental health; lowlevels contribute to oxidative stress and inflammation





Amino acid arginine found to be crucial to mental health; low levels contribute to oxidative stress and inflammation

Mental health problems aren't always easy to treat but now that researchers have found an amino acid called arginine may help. This amino acid reduces oxidative tress and inflammation which lowers the risk of developing mental illness such as anxiety and depression. Improving your diet and supplementing with a supplement containing amino acid arginine could be the key to finally beating these conditions and the decreased quality of life they often bring to the patients suffering.

Key Takeaways:

  • Some people struggle with their own mind and they do not know how to cope with it.
  • There are some things that can help someone be okay with themselves and they are more healthy this way.
  • So many things, like arginine, actually have a massive role to play in the battle for people with mind issues.

"Still, the authors argue that more research should be conducted to truly determine the role of amino acids (particularly those that reduce inflammation) in mental health."

Read more: https://www.naturalnews.com/2018-09-16-amino-acid-arginine-found-to-be-crucial-to-mental-health.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5778)


Health Watch: What Do You Know About Vitamin K?
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Date: December 30, 2017 03:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Health Watch: What Do You Know About Vitamin K?





Most people are familiar with benefits of vitamins. The most common vitamins with which people are familiar are A, B, C, D and E. However few people know about the benefits of vitamin K. It derives from the German word Koagulation which is similar to the English word coagulation. That refers to blood clotting. Most people are not deficient in vitamin K unless they suffer from malnourishment. Babies are usually given a shot of vitamin k within a day of birth to stimulate coagulation. There are a number of forms of vitamin K with K1 being the most common. It is also the one present in green vegetables. When people have blood clots, strokes or abnormal heart rhythms, doctors often prescribe anti K drugs such as warfarin which act as anticoagulants. Food high in vitamin K can aid in having a healthy heart. Foods that are high in vitamin K include green vegetables such as kale, spinach, collard greens, parsley, broccoli and Brussels sprouts. Fruit , milk and meat also have vitamin k in different quantites. Vitamin K also comes in K2 and K3 versions which also aid in bone health. In fact study of 72,000 women over a decade followed by the The Nurses' Health Study found that those with less than 109 micrograms a day of vitamin K were 30% more likely to suffer a hip fracture. Overall Americans are not eating enough vitamin K. Eating more would promote healthier cardiovascular systems and stronger bones.

Key Takeaways:

  • Vitamin K is required by the human body for coagulation or clotting of blood.
  • Dietary sources of Vitamin K include but are not limited to kale, blueberries, spinach, mustard greens, and broccoli.
  • Some anticoagulant medications may interfere with the action of Vitamin K.

"K2, as well as K1, are believed to play an important role in bone health; low levels have been associated with an increased risk of both osteoporosis and arthritis."

Read more: http://www.caledonianrecord.com/features/health/health-watch-what-do-you-know-about-vitamin-k/article_b2ae97dd-2bd4-57df-8a42-307a4d5fe6a0.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5465)


Probiotics: Research Beyond the Belly...and to the Brain and Heart)
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Date: June 13, 2017 04:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Probiotics: Research Beyond the Belly...and to the Brain and Heart)





Probiotics are a very successful thing. It is very popular among consumers and also among clinicians. The digestive tract is considered a main hub in our bodies. They have a long track record of digestive health and other positive things. Your digestive and immune health. The research on the links between probiotics and the heart is still in the very early stages. There are many factors to consider in this area. There is still much developing in this area.

Key Takeaways:

  • Though research on the ties linking probiotics with the heart and the head remains in its early stages, the notion that there’s a real “there” there is gaining traction
  • “The digestive tract is considered a main hub in our bodies and has an effect on almost every other vital bodily function—making it crucial that we keep it in balance,” Keller observes
  • While the gut-brain axis is an emerging focus of research, and while early results in mood and anxiety look promising, we’re still a long way from improving cognition and memory,” he says.

"The latest eye-opener: Not only do probiotics have a proven track record of promoting digestive and immune health; emerging findings associate some strains with marked improvements in cognition and cardiovascular wellness, to boot."

Read more: http://www.nutritionaloutlook.com/brain-health/probiotics-research-beyond-bellyand-brain-and-heart

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4826)


Health Benefits Of Black Sesame Seed Oil | Health Tips Education
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Date: February 04, 2017 10:19 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Health Benefits Of Black Sesame Seed Oil | Health Tips Education





Black sesame seed oil has many minerals and qualities that are very important for human health. Used as a culinary additive when cooking or even rubbed into the skin, black sesame seed oil can be beneficial for: heart health; hair health; bone health; skin health; anti-inflammatory effect; blood pressure reduction; cancer and diabetes.

https://www.youtube.com/watch?v=UxurvVZeTFI

Key Takeaways:

  • Can improve hair health
  • Boost bone health
  • Helps keep skin nourished

"Using black sesame seed oil, either topically or by consumption, can help reduce ailments and conditions caused by inflammation."

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3880)


HEALTHY BENEFITS OF ALMOND FLOUR
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Date: January 28, 2014 08:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HEALTHY BENEFITS OF ALMOND FLOUR

almond nutsBenefits of Almond

Almond is considered one of the earliest domesticated tree, the tree produce the drupe consisting of a hard shell and with a seed inside. The seed is grind to make the almond flour, which is used to make different kind of recipes, almond flour, is nutritious and also high in protein, low sugar and carbohydrates. Unlike other domestically used flour, almond flour is delicious in terms of taste.

Regular and daily use of Almond flour is good for the health; here are health benefits of almond flour;

Protects Arteries

When using Almond flour, reduces the chances and reduces the risk of heart disease, the flavonoids in the almond skin works with vitamin E which act as antioxidant, where it protect the arty walls from damages.

Weight Loss

Almonds is low in sugars and carbohydrates which are responsible to generate body fat, the almond provide healthy fats, just enough that is required by the body. Using the almond flour at least 2 times per week will help in balancing the body fat thus aid in weight loss.

Energy Nutrients

Almond is naturally low on cholesterol, but contain a limited amount of carbohydrates, which is a good source of fiber, certain amount of almond contain enough calories, protein, that are capable to give you energy to go all day long.

Brain and nervous system function

Almond flour contain L-carnitine and riboflavin nutrient, this nutrients help boost brain activities and stimulate the nervous system, they are also responsible in reducing the risk of Alzheimer’s disease. If used often the almond increase longevity and intellectual levels.

Rich in vitamin

The Almond flour is the best source of Vitamins; it contains vitamin E and vitamin B, and niacin, this vitamins support immune system and serves to protect cells against damage.

Alkalize the body

The almond flour has few protein that are able to form alkaline, this is a good course meal when you are low in alkaline, with low alkaline the body may be at risk of Osteoporosis, unhealthy weight gain and poor immune system. Almond reduce the rise in blood sugar and insulin after almond meal, the healthy benefit a lot beyond measure, if feed to the young ones, it help build strong teeth and bones.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2990)


Omega-3 Fish Oil
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Date: May 02, 2008 03:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Omega-3 Fish Oil

The benefits of fish oil come from two long chain polyunsaturated fatty acids: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). DHA primarily helps prevent behavioral and attention issues in children and adults. DHA is good for brain development starting as far back as when we are developing in the womb.

Scientists at Wayne State University in Detroit found that babies who had higher concentrations of DHA in their cord blood had greater visual, cognitive, and motor development when tested at the six month and twelfth month marks. Most pregnant women get less DHA then they need during those last few months of pregnancy. Supplementing with DHA can have profound benefits for baby as well as mother. DHA can extend gestation time which can reduce the rate of premature birthing. Some research suggests that DHA can help fight pre-eclampsia, a life threatening condition that happens to women that are pregnant. Omega-3 fish oil reduces platelet aggregation and vasoconstriction – both of which are symptoms of pre-eclampsia.

Eating fish is a good way to get the needed DHA in our diets but safety is always an issue with the fish that is being consumed. Cold water fish have been known to have potential toxins like mercury, polychlorinated biphenyls, and dioxins. These toxins are not good for developing baby as well as the mother.

Brain power can be boosted in babies who are breast fed because of the high concentrations of DHA present in breast milk. Infants begin developing neuronal pathways associated with learning as soon as they are born and if they are not breast fed they should be supplementing their diet with DHA. Studies suggest that DHA plays a role in the production and regulation of dopamine and serotonin in the brain. Numerous studies show that breast fed babies have greater cognitive development and visual acuity then those who are formula fed.

The importance of fish oil for infants in brain development is clearly seen, fish oil is also important for older children and adults who want a mental boost. It’s never too late to take fish oil to boost mental health; studies suggest that Alzheimer’s disease can be slowed with the consumption of omega-3 fish oil as well. Have you had your fish oil today?

If burping up fish oil is not your cup of tea, give vectomega a try. vectomega is a dry fish oil that provides the same health benefits you experience with regular oil pills minus the oil.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1781)


Fruit and Vegetable Lightning drink mixes from Natures Plus
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Date: February 06, 2007 02:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Fruit and Vegetable Lightning drink mixes from Natures Plus

Enjoy the Rainbow – the Color Wheel of Fruits and Vegetables

 

We’ve all heard the statistics, and have probably seen the signs in the produce section of our favorite grocery store: eating 5 servings of fruits and veggies a day is important,

 

Chances are also pretty good that we’ve also seen the newest food pyramid, encouraging Americans to “eat a rainbow of frits and vegetables.” That is, choose from the rich variety of colors for the best all-around health benefits.

 

In this Ask the Doctor, we’re going to look at the unique health components of different colored fruits and vegetables, and why they’re so important. Plus, we’ll learn about supplemental options, like fruit and vegetable drink mixes, for those days when our diets just aren’t that great.

 

Q. What’s the big deal about fruits and vegetables?

A. Well, for the main reason that they are whole foods – created by nature (or at least generations of farming) and are rich in a variety of nutrients. Processed foods can’t match the health benefits of strawberries or broccoli – items that have fiber, vitamins, and enzymes built right in.

 

Q. What does “eating a rainbow” of fruits and vegetables really mean?

A. This is simply an easy way of remembering to get as much color variety in your diet as possible to maximize your intake of a broad range of nutrients. The colors of fruits and vegetables are often a tangible clue to the unique vitamins and other healthy substances they contain. Getting a variety of colors, therefore, means getting a variety of the essential nutrients your body needs to stay healthy and strong.

 

Enjoying the Rainbow: Fruit and Vegetable Benefits:

Color

Source

Nutrients

Benefits

Red

Tomatoes, Berries, Peppers, Radishes

Lycopene, Anthocyanins, Ellagic Acid, Bioflavonoids including Quercetin, and Hesperidin

Reduces risk of prostate cancer; lowers blood pressure; scavenges harmful free-radicals; reduces tumor growth; reduces LDL cholesterol levels and supports joint tissue in cases of rheumatoid arthritis

Orange/ Yellow

Carrots, Yams, Squash, Papaya

Beta-carotene, Zeaxanthin, Flavonoids, Lycopene, Vitamin C, Potassium

Reduces age-related macular degeneration; lowers LDL (bad) cholesterol; fights harmful free radicals; reduces risk of prostate cancer, lowers blood pressure; promotes collagen formation and healthy joints; encourages alkaline balance and works with magnesium and calcium to build healthy bones

White

Mushrooms, White Tea, Flaxseed/ Pumpkin

Beta-glucan, EGCG (epigallocatechin gallate), SDG (secoisolariciresinol digulcoside), lignans

Provides powerful immune boosting activity; activates natural-killer cells, B-cells and T-cells; may reduce risk of colon, breast and prostate cancers; boosts immune-supporting T-cell activity; balances hormone levels and may reduce risk of hormone-related cancers

Green

Wheat Grass, Barley Grass, Oat Grass, Kale, Spinach, Cabbage, Alfalfa Sprouts, Mustard Greens, Collard Greens

Chlorophyll, Fiber, Lutein, Zeaxanthin, Calcium, Folate, Glucoraphanin, Vitamin C, Calcium, Beta-Carotene

Reduces cancer risks; lowers blood pressure; normalizes digestion time; supports retinal health and reduces risk of cataracts; builds and maintains bone matrix; fights harmful free-radicals; boosts immune system activity; supports vision and lowers LDL cholesterol levels

Purple/ Blue

Blueberries, Pomegranates, Grapes, Elderberries, Eggplant, Prunes

Anthocyanins, Lutein, Zeaxanthin, Resveratrol, Vitamin C, Fiber, Flavonoids, ellagic acid, quercetin

May protect brain cells against Alzheimer’s and other oxidative-related diseases; supports retinal health; lowers LDL cholesterol and prevents LDL oxidation; boosts immune system activity and supports healthy collagen and joint tissue; supports healthy digestion; improves calcium and other mineral absorption; fights inflammation; reduces tumor growth; acts as an anticarcinogen in the digestive tract, limits the activity of cancer cells –depriving them of fuel; helps the body fight allergens

 

Q. Can you tell me a little more about the healthy components of fruits and vegetables?

Let’s take a look at some of the most well-studied and important nutrients:

 

Quercetin is found in apples, onions and citrus fruits (also is hawthorn and other berries and apple-related fruits usually used in traditional herbal remedies and modern supplements). It prevents LSL cholesterol oxidation and helps the body cope with allergens and other lung and breathing problems.

 

Clinical studies show that quercetin’s main points of absorption in the body appear to be in the small intestine – about 50%. The rest – at least 47% is metabolized by the colonic micro flora – the beneficial bacteria such as Lactobacillus acidophilus and Bifidobacterium longum. You may consider adding these beneficial bacteria (found in yogurt) either through the diet or a supplemental form.

 

Ellagic Acid is a component of ellagitannins – dietary polyphenols with antioxidant (and possibly anticancer) properties. Polyphenols are the basic building blocks of many plant-based antioxidants. More complex phenolic compounds, such as flavonoids are created from these molecules.

 

Ellagic acid is found in many fruits and foods, namely raspberries, strawberries, pomegranates, and walnuts. Clinical studies suggest that ellagitannins and ellagic acid act as antioxidants and anticarcinogens in the gastrointestinal tract.

 

Ellagitannins are durable antioxidants, and happily, they do not appear to be diminished by processing, like freezing. This means the benefits are still strong, even in frozen packs of raspberries or strawberries, or some of the better multi-ingredient supplement drink mixes.

 

In scientific studies, ellagic acid also showed an anti-proliferative effect on cancer cells, decreasing their ATP (adenosine triphosphate) production. ATP is the molecule that provides the primary energy source for the cells in our bodies. In a sense, ellagic acid seems to deprive cancer cells of their fuel.

 

Beta-Carotene: Probably the best-known of the carotenoids, beta-carotene is converted by the body into vitamin A. Many vegetables, especially orange and yellow varieties, are rich in this nutrient. Think summer squash, yams and of course, carrots.

 

Beta-carotene has long been associated with better eyesight, but it has other benefits, too. In a scientific study, beta-carotene decreased cholesterol levels in the liver by 44% and reduces liver triglycerides by 40%.

 

Lycopene is a carotenoid mostly found in tomatoes, but also in smaller amounts in watermelon and other fruits. Clinical studies have shown that lycopene consumption may decrease the risk of prostate cancer. In fact, high intakes of lycopene are associated with a 30% to 40% reduced risk. And, as good as beta-carotene is, its cousin, lycopene, seems to be an even stronger nutrient, protecting not just against prostate cancer, but heart disease as well.

 

Lutein is found in many fruits and vegetables, including blueberries and members of the squash family. Lutein is important for healthy eyes, and in fact it is found in high concentrations naturally in the macular region of the retina – where we see fine detail. It is one of the only carotenoids, along with its close sibling zeaxanthin, that is found in the macula and lens of the eye.

 

Lutein also supports your heart, too. In a scientific study, lutein reduced atherosclerotic lesion size by 43%. In other words, high intakes of lutein may actually help prevent coronary artery disease!

 

Interestingly, as is the case with lycopene, cooking or processing foods with lutein may actually make it more easily absorbed.

 

In clinical studies, men with high intakes of lutein (and its close cousin, zeaxanthin, found in broccoli and spinach) had a 19% lower risk of cataract, and women had a 22% decreased risk, compared to those whose lutein intakes were much lower.

 

Vitamin C: One of the best-known nutrients out there, vitamin C keeps our immune system strong; speeds wound healing, and promote strong muscles and joints. A free-radical fighter, vitamin C prevents oxidative damage to tissues, builds strength in collagen and connective tissue, and even reduces joint pain.

 

Sources of vitamin C are scattered throughout the spectrum of fruits and vegetables. Oranges and other citrus are the most commonly associated with vitamin C, but it also is present in tomatoes, and to a lesser extent in berries and cherries.

 

Potassium: Most Americans are deficient in potassium. For the most part, it’s hard to get too much of this valuable mineral. Potassium does great things for our hearts. Higher intakes of dietary potassium from fruits and vegetables have been found in clinical research to lower blood pressure in only 4 weeks.

 

Many researchers believe that the typical American diet has led to a state of chronic, low-grade acidosis – too much acid in the body. Potassium helps change pH balance to a more alkaline environment in the body and increases bone density.

 

This was proven in the long-running Framingham Heart Study which showed that dietary potassium, (along with magnesium and fruit and vegetable intake) provided greater bone density in older individuals.

 

Fiber is another food component many just don’t get enough of – especially if they’re eating a “typical American diet.” Fruits, vegetables and whole grains are excellent sources of fiber. However, fiber from a good fruits and vegetable drink mix should be derived from inulin and chicory root. This soluble fiber source not only adds to the overall amount of fiber you need (25 to 38 grams a day), but also provides a nice “nesting ground” for the beneficial bacteria that populate the intestines. And, even though some fiber has a bad rap for inhibiting mineral absorption, inulin and chicory root are “bone building” fibers – they actually help the body absorb calcium.

 

Flavonoids are an overarching term that encompasses flavonols, anthocyanidins, and flavones, isoflavones, proanthocyanidins, Quercetin and more. They are almost everywhere: in fruits, vegetables, grains, herbs, nuts and seeds – even in the coffee, wine and tea we drink. Flavonoids are responsible for the colors in the skins of fruits and the leaves of trees and other plants.

 

Flavonoids have many health benefits. They can help stop the growth of tumor cells and are potent antioxidants. Additionally, flavonoids have also been studied for their ability to reduce inflammation.

 

Anthocyanins: High on the list of important “visible” nutrients are anthocyanins. They color fruits and vegetables blue and red.

 

Anthocyanins are members of this extended family of nutmeats, the flavonoids. Typically found in high amounts in berries, anthocyanins are readily absorbed in the stomach and small intestine.

 

As antioxidants, anthocyanins dive deep into cell membranes, protecting them from damage. IT may be one reason why the anthocyanins from blueberries are considered such an important component in battling neuronal decline, like Alzheimer’s. Blackberries, raspberries, and strawberries are also excellent sources of this flavonoids group.

 

SDG lignans, (short for secoisolariciresinol diglucoside) are polyphenolic components of flaxseed, pumpkin and other herbal sources. Much of the recent research surrounding lignans has focused on flaxseed. In scientific and clinical studies, lignans from flaxseed support hormonal balance and may have cancer-preventing abilities. In fact, in one study, flaxseed lignans reduced metastatic lung tumor by 82% compared to controls.

 

The lignans in pumpkin seed, also considered a major source, target 5-alpha reductase activity.

 

This enzyme catalyzes the conversion of testosterone into the more potent dihydrotestosterone (DHT). DHT, like testosterone, is a steroid hormone or androgen. Androgens are responsible for the development and maintenance of masculine sex characteristics in both men and women. Excess levels of DHT can cause serious problems with prostate or bladder health. That’s why modulation of the 5-alpha reductase enzyme is so important – it helps maintain healthy testosterone and DHT levels. By balancing the levels of these key hormones, pumpkin seed lignans provide protection for prostate and bladder cells.

 

In addition, pumpkin seed has been shown to modulate the enzyme aromatase. Aromatase is present in the estrogen-producing cells of the adrenal glands, ovaries, testicles, adipose tissue, and brain. Aromatase converts testosterone, an androgen, into estradiol, and estrogen.

 

Inhibition of the aromatase conversion can help maintain a balance of healthy testosterone levels in women, which has been shown to strengthen pelvic muscles and reduce incidence of incontinence.

 

In fact, a clinical study, involving a pumpkin extract in conjunction with soy, resulted in significant support for bladder health. After two weeks of supplementation, 23 of the 39 postmenopausal women enrolled in the study showed great improvement in urinary frequency and sleep. By the end of the six week study, 74.4 percent of participants found pumpkin extract safely and significantly improved “nocturnia,” that is, the need to urinate frequently at night. For individuals with 2 to 4 episodes of nocturnia prior to the stud, and 81.8% improvement was seen – also showing great improvement in sleep quality. After all, if you don’t have to wake up every couple of hours to go to the bathroom you’re bound to get better sleep.

 

Beta glucan: Mushrooms are intense immune-boosting powerhouses due to their beta-glucan content. Three well-studied power-house mushrooms that contribute beta glucan to the diet include maitake, reishi and shiitake.

 

The most significant constituents of mushrooms are long chain polysaccharides (molecules formed from many sugar units) known as beta-glucan. These huge molecules act as immunoregualtors in the human body, helping to stabilize and balance the immune system.

 

This includes specific support of white blood cells, or lymphocytes, the primary cells of the immune system. Lymphocytes fall broadly into three categories: T cells, B cells, and natural killer (NK) cells.

 

In one clinical study, 165 patients with various types of advanced cancer were given maitake mushroom compounds alone or with chemotherapy. Cancer regression or significant symptom improvement was observed in 58% of liver cancer patients, and 62% of lung cancer patients. Plus, when maitake was taken in addition to chemotherapy, the immune cell activities were enhanced 1.2 to 1.4 times, compared with chemotherapy alone.

 

In another clinical study, researchers determined that Reishi increased the number of cancer killing white blood cells and made them more deadly to cancer cells.

 

And, in a scientific study of human breast cancer and myeloma cancer and myeloma cancer cell lines, shiitake compounds provided a 51% antiproliferative effect on the cells – inducing “apoptosis’ – the programmed cell death that should occur naturally.

 

While beta-glucan are distributed throughout the mushroom body, the beta-glucan concentrations are significantly higher in the mycelium – the interwoven fibers or filaments that make up the “feeding structure” of the mushroom.

 

Bioflavonoids are commonly found in bright yellow citrus fruits, including lemons, limes and oranges. They are responsible for the bright pigment found in the skin of the fruit, and are considered a “companion” to vitamin C, seeming to extend the value of the nutrient within the body.

 

Hesperidin is just one of the valuable bioflavonoids found in citrus. Hesperidin appears to lower cholesterol levels, as well as support joint collagen in examples of rheumatoid arthritis.

 

Epigallocatechin gallate (EGCG):

Polyphenols, most notably EGCG, or epigallocatechin gallate, are well-studied and powerful components of tea. EGCG has been shown to reduce colon and breast cancer risk. Green tea also boosts the immune system and encourages T-cell formation – part of the front-line defense of our bodies against sickness and disease.

 

Q. I’ve been seeing articles about fruits, vegetables and supplements touting “high ORAC value.” What does this mean?

ORAC is an acronym for Oxygen Radical Absorption Capacity, and is simply a measurement of antioxidant activity of nutrients. Oxygen radicals, or free radicals, are unstable molecules. They grab electrons from other cells to use for themselves, and in the process can damage them. It is believed that free radical activity plays a role in the development of many diseases such as heart disease and cancer, and also plays a role in aging.

 

Antioxidants help prevent this damage by “loaning out” extra electrons to stabilize free radicals/ Consider any fruit or vegetable with a high ORAC rating as having a lot of “antioxidant power.”

 

I know I should eat more fruits and vegetables, but it just seems so hard to get five servings a day.

The number one excuse I hear for not buying frits and veggies is that “fruits and vegetables are too expensive.” But are they really? Certainly, fresh foods that aren’t in season and have to be shipped a distance can be a bit pricey. If anyone added up how much spend on fast food, or prepackaged or processed snacks, it would probably be shocking.

 

Luckily, there are many ways to get your “Daily 5”. For instance, frozen fruits and veggies retain much of their nutrient profile. They can be an excellent alternative when certain foods are out of season. So too, are fruit and vegetable drink mixes – excellent supplemental sources of some of the nutrients our bodies need most.

 

More recently, the American Institute of Cancer Research discovered a reason many adults don’t eat their vegetables is – I’m not making this up – “a fear of flatulence.”

 

Of course, for people not accustomed to the fiber in fruits and veggies, there is some reason to think it’ll increase gas. When cell walls break down, and fiber passes through the system, it can create flatulence. Folks who eat fruits and vegetables every day generally don’t have this problem. Their systems are already accustomed to it.

 

For those just starting out on a better diet, however, start slowly – it helps your body adapt. Cooking vegetables can help, too, because it begins breaking down the cell walls early on.

 

One thing is certain, however. The “Typical American Diet” and good health are mutually exclusive. The increase in type 2 diabetes, heart disease, high cholesterol, and hypertension all point to the abuse our bodies suffer by eating diets high in fatty meats, processed sugars, and refined grains.

 

Q. Can I just drink fruit and vegetables drinks in place of 5 servings of fruits and vegetables?

Green drinks and fruit and vegetable drink mixes aren’t meant to replace whole foods, but they can be an excellent substitute when you’re rushed or traveling or just trying to fill everyday nutritional gaps. Their whole food ingredients absorb very easily and gently in the gut, and many of these drink mixes contain healthy doses of fiber, too.

 

Green drink mixes and food-based drink mixes combine many colorful fruits and vegetables and sometimes grasses in a healthy, mixable supplement assortment. While there have been many advancements in the field of green drinks, there are only a few that take the primary reason we eat into consideration: taste!

 

Happily, there are some companies out there with great-tasting drink mixes that also formulate based on the color concept, ensuring you get the broadest assortment of nutrients from a full range of fruit and vegetable colors to promote optimal health.

 

High-quality fruit and vegetable drink mixes offer the best from nature’s color wheel in a convenient and great-tasting supplement. So, the next tie you feel like taking a coffee break – try a fruit and veggie break instead. Your body and spirit will thank you.

 

 



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Your emotions, your thoughts may effect your health...
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Date: August 09, 2005 03:10 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Your emotions, your thoughts may effect your health...

Your emotions, your thoughts May effect your health

Concerning the supposed connection between positive emotions and overall health, many feel that, well, they’re not so connected. It is interesting to note that they’d be right—and wrong. The way we think and feel has a definite correlation to our health; in other words, our bad thoughts and emotions may affect us in the same manner as our good ones. In a recent study at Duke University, a research professor discovered that high levels of hostility have been shown to lead to an increased susceptibility of coronary disease by the age of 50.

These “hostile” people are four to seven times more likely to have coronary problems, mainly due to the stress the hostile emotions put on their body. Negative thoughts and feelings can affect the state of your health, usually in the form of stress.

“A group of researchers found that the number of ill-nesses suffered decreased as peopl e had mor e positive thoughts, including a relief.”

On the other hand, a group of researchers found that the number of illnesses suffered decreased as people had more positive thoughts, including a relief from stress-based illnesses. The negative thoughts were thought to be a factor contributing to these people’s decreased state of health, and as the “bad thoughts” lessened and the “good thoughts” increased, the overall state of health seemed to improve. Ultimately, your health and mood are connected—they influence one another. The brain and the nervous system work hand in hand, and any differences in the levels of hormones and neurotransmitters can affect your mood positively and negatively. One timeproven method for fighting off a bad mood is exercise. Exercise stimulates a release of endorphins, which work to improve your mood and alleviate stress.



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The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
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Date: June 09, 2005 05:22 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease

The Latest Breakthroughs in Garlic Research

on Cancer and Cardiovascular Disease

Presented at the 2005 World Garlic Symposium

Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.

“For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”

Presentation highlights included:

  • • Clinical Intervention Trial and pre-clinical substantiation on Cancer using Garlic, presented by National Cancer Institute scientists, Mitchell Gail and John Milner Mounting evidence points to the anticancer properties of aged garlic extract and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis.

  • • Inhibition of Coronary Arterial Plaque Accumulation by Garlic, presented by Matthew Budoff, Harbor-UCLA Medical Center

    Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.

  • • Influence of Garlic on Endothelial Dysfunction in Hyperhomocysteinemia, presented by Norbert Weiss, University of Munich in Germany Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute high homocysteine on endothelium-dependent brachial artery vasodilatation and on acetylcholine-induced stimulation of skin perfusion.

  • • Anti-glycation properties of aged garlic extract: possible role in prevention of diabetic complications, presented by Nessar Ahmed, Manchester Metropolitan University in England Aged garlic extract inhibited the formation of advanced glycation end products, which have been previously shown to increase the risk of diabetic complications ranging from heart disease to retinopathy, kidney failure, impaired wound healing and many more.

    “Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”

    Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .

    Abstracts

    PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892

    Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.

    INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA

    Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.

    INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany

    Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.

    Bibliographies

    David Heber, MD, PhD, FACP, FACN

    Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center

    Matthew Budoff, MD, FACC

    Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.



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    Glycerylphosphorylcholine -- Supports Cognitive Function in AD ...
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    Date: May 24, 2005 09:52 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Glycerylphosphorylcholine -- Supports Cognitive Function in AD ...

    Cognitive Improvement in Mild to Moderate Alzheimer's Dementia After Treatment with the Acetylcholine Precursor Choline Alfoscerate: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Maria De Jesus Moreno Moreno, MD Instituto Nacional de la Senectud, Mexico City, Mexico


    This study assessed the efficacy and tolerability of the cholinergic precursor choline alfoscerate (CA) in the treatment of cognitive impairment due to mild to moderate AD (Alzheimer's disease).

    in both men and woman they consistently improved after 90 and 180 days versus baseline with adiministration of GPC three times a day, whereas in the placebo group they remained unchanged or worsened. Statistically significant differences were observed between treatments after 90 and 180 days.

    Keypoints:

  • improved cognition and global function
  • showed a statistically significant improvement after 90 and 180 days of treatment
  • Increased neurotransmission
  • With out treatment men and woman declined consistantly
  • references:

    Bartus RT, Dean RL III, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction, Science. 1982;217:408-414. 2. Larson EB, Kukull WA, Katzman RL. Cognitive impairment: Dementia and Alzheimer's disease. Annu Rev Public Health. 1992;13:431-449. 3. Hofman A, Rocca WA, Brayne C, et al, for the European Prevalence Research Group. The prevalence of dementia in Europe: A collaborative study of 1980-1990 findings. Int d Epidemiol. 1991;20:736-748. 4. Blackwood W, Corsellis JAN, eds. Greenfield's Neuropathology. 3rd ed. London: Arnold; 1976. 5. Geldmacher DS. Cost-effective recognition and diagnosis of dementia. 5emin Neurol. 2002;22:63-70. 6. Perry EK, Tomlinson BE, Blessed G, et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. BMJ. 1978;2:1457-1459. 7. Perry EK. The cholinergic hypothesis--ten years on. Br Med Bull. 1986;42:63-69. 8. Giacobini E. From molecular structure to Alzheimer therapy. Jpn d Pharmacol. 1997;74:225-241. 9. Giacobini E. Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: From tacrine to future applications. Neurochem Int. 1998;32:413-419. 10. Brinkman SD, Smith RC, Meyer JS, et al. Lecithin and memory training in suspected Alzheimer's disease. J Gerontol. 1982;37:4-9. 11. Davis E, Emmerling MR, Jaen JC, et al. Therapeutic intervention in dementia. Crit Rev Neurobiol. 1993;7:41-83. 12. Amenta E Parnetti L, Gallai V, Wallin A. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropiate approaches? Mech Ageing Dev. 2001;122:2025-2040. 13. Sigala S, Imperato A, Rizzonelli P, et al. k-Alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat. Eurd Pharmacol. 1992;211:351-358. 14. Govoni S, Battaini E Lucchi L, et al. Effects of alpha-glycerylphosphorylcholine in counteracting drug-induced amnesia: Through cholinergic and non-cholinergic mechanisms [in Italian]. Basi Raz Ter. 1991;21:75-78. 15. Canonico PL, Nicoletti F, Scapagnini U. Neurochemical and behavioral effects of alpha-glycerylphosphorylcholine [in Italian]. Basi Raz Te~ 1990;20: 53-54. 191 CLINICAL THERAPEUTICS ® 16. Parnetti L, Amenta E Gallai V. Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: An analysis of published clinical data. Mech Ageing Dev. 2001;122:2041-2055. 17. Venn RD. The Sandoz Clinical Assessment-Geriatric (SCAG) scale. A general-purpose psychogeriatric rating scale. Gerontology. 1983;29:185-198. 18. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res. 1991;19:330-341. 19. Frattola L, Piolti R, Bassi S, et al. Multicenter clinical comparison of the effects of choline alphoscerate and cytidine diphosphocholine in the treatment of multi-infarct dementia. Curt Ther Res Clin Exp. 1991;49:683-693. 20. Muratorio A, Bonuccelli U, Nuti A, et al. A neurotropic approach to the treatment of multi-infarct dementia using L-c~-glycerylphosphorylcholine. Curt Ther Res Clin Exp. 1992;52:741-75l. 21. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: APA; 1994. 22. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944. 23. Folstein ME Folstein SE. "Mini-mental state": A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12:189-198. 24. Loeb C, Gandolfo C. Diagnostic evaluation of degenerative and vascular dementia. Stroke. 1983;14:399-401. 25. Hamilton M. A rating scale for depression.J Neurol Neurosurg Psychiatry. 1960;23:56-62. 26. Hamilton M. Development of a rating scale for primary depressive illness. BrJ Soc Clin Psych& 1967;6:278-296. 27. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. AmJ Psychiatry. 1984;141:1356-1364. 28. Reisberg B, Ferris SH, De Leon MJ, et al. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry. 1982;139:1136-1139. 29. National Institute of Mental Health. Clinical global impressions. In: Guy W, ed. ECDEU Assessment for Psychopharmacology. Revised edition. Rockville, Md: National Institute of Mental Health; 1976:217-222. 30. Burns A, Russell E, Page S. New drugs for Alzheimer's disease. Br J Psychiatry. 1999;174:476-479. 31. Kumar V, Anand R, Messina J, et al. An efficacy and safety analysis of Exelon in Alzheimer's disease patients with concurrent vascular risk factors. Eur J Neurol. 2000;7:159-169. 32. Knapp MJ, Knopman DS, Solomon PR, et al, for the Tacrine Study Group. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA. 1994;271:985-991. 192 M. Moreno 33. Lindstrom MJ, Bates DM. Newton-Rapshon algorithms for linear-mixed effects models for repeated measure data. J Am Stat Assoc. 1998;83:1014-1022. 34. Thai LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology 1996;47:705-711. 35. Rogers SL, Friedhoff LT, for the Donepezil Study Group. The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicentre, randomized, double-blind, placebo-controlled trial. Dementia. 1996;7:293-303. 36. Rogers SL, Doody RS, Mohs RC, Friedhoff LT, for the Donepezil Study Group. Donepezil improves cognition and global function in Alzheimer disease: A 15-week, double-blind, placebo-controlled study. Arch Intern Med. 1998; 158:1021-1031. 37. Corey-Bloom J, Anand R, Veach J, for the ENA 713 B352 Study Group. A randomized trial evaluating the efficacy and the safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease. Int J Geriatr Psychopharmacol. 1998;1:55-65. 38. Rosler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomised controlled trial. BMJ. 1999;318: 633-638. 39. Amenta E Bronzetti E, Del Valle M, Vega JA. Effects of alpha-glycerylphosphorylcholine in neuroanatomy of aging brain in experimental animals [in Italian]. Basi Raz Te~: 1990;20:31-38. Address correspondence to: Scientific Department, Italfarmaco SpA, via dei Lavoratori 54, 20092 Cinisello Balsamo, Milan, Italy.

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