Search Term: " mea-analysis "
New meta-analysis finds that proper vitamin D levels greatlyimprove the health of diabetics and heart patients
May 17, 2019 04:03 PM
Up to a billion people worldwide may not be getting enough vitamin D, and this is a real problem because vitamin D deficiency can increase the risk of cancer, obesity and other health problems. Meta-analysis published by Current Pharmaceutical Design suggests that getting enough vitamin D can decrease fasting glucose and reduce insulin resistance. Vitamin D can also help moderate your bad cholesterol, as well as reducing your levels of C-reactive protein, which is a sign of inflammation.
"Three of the most significant risk factors for heart disease are high cholesterol, chronic inflammation, and insulin resistance. Researchers wanted to learn more about whether vitamin D supplementation is a way to lower the risk of heart disease or reduce complications in patients who already have it."
Read more: https://www.naturalhealth365.com/vitamin-d-glycemic-control-2947.html
Omega-3 fatty acids can treat male infertility
March 27, 2019 12:08 PM
Medical experts located in Iran and Australia have been studying the connection between the consumption of omega-3 fatty acids and how it can impact male fertility. The study consisted of 143 men that had their semen tested in order to see if it had appropriate levels of DHA and EPA, which are two main components in active fertile responses in men. After consistently taking in omega-3 fatty acids, a recognizable increase in both DHA and EPA were shown.
"In conclusion, the findings of the systematic review and meta-analysis suggest that supplementing infertile men with omega-3 fatty acids may significantly improve sperm motility and seminal DHA concentration."
Read more: https://www.naturalnews.com/2019-01-25-omega-3-can-treat-male-infertility.html
Another study finds turmeric and curcumin to be a safe, effectivetreatment for lowering cholesterol and protecting the heart
November 19, 2018 09:36 AM
Turmeric and its much-lauded, health-giving component, curcumin, have had a health buzz about them for a long time. The health benefits to those that use turmeric and consequently curcumin, have long been noted. But, though its benefits for a wide array of bodily systems, including the cardiovascular, are not disputed, it has heretofore not been understood if turmeric, or more specifically curcumin, does some of its wonders by lowering lipid levels. The Second Affiliated Hospital of Chongqing Medical University has now performed a meta-analysis of available data, surrounding turmeric and curcumin, as a means of filling the knowledge gap. The researchers began by filtering the data, searching for studies revolving around turmeric, cholesterol and triglycerides. To ensure the data was all the more compelling and germane, the researchers trimmed down the parameters even more, allowing for only those tests that involved subjects laboring under the effects of metabolic syndrome or type 2 diabetes. In these cases possible negative effects to the heart would prove particularly relevant. The meta-analysis revealed that turmeric and curcumin had positive effects to impart on the levels of serum triglycerides apparent in its user-subjects. The two components also positively impacted the low-density lipo-protein cholesterol levels of the user-subjects. The researchers theorized that positive chemical activity was initiated by the components, thereby causing the beneficial aspects. Other cholesterol and lipid markers were not affected. In general, turmeric and curcumin have been shown to limit oxidative stress and inflammation as well as benefit the blood vessel lining, all of which can prevent a serious cardiac event.
"Turmeric and curcumin are two substances most known for their wide array of health benefits."
Chlorella supplementation 'more effective in unhealthy subjects,' researchers say
October 26, 2017 10:14 AM
This is interesting research on chlorella supplementation. It actually turns out that unhealthy subjects responded better to it than healthier ones. This is probably due to the fact that their health was so much in need of improvement. There need to be more studies on this subject now because we need to know which health conditions would respond the best to it. Scientific studies do well when they have a diverse group of test subjects with different conditions.
"Consuming chlorella as a supplement improved levels of total cholesterol, systolic blood pressure, and other indicators of cardiovascular disease risk—but may be a better value to unhealthy populations, according to a new meta-analysis."
Read more: https://www.nutraingredients-usa.com/Article/2017/10/19/Chlorella-supplementation-more-effective-in-unhealthy-subjects-researchers-say
Do Prebiotic and Probiotic Supplements Decrease Systemic Inflammation?
October 10, 2017 10:14 AM
Prebiotics and probiotics are good bacteria. They help your body handle many processes. They may help with systemic inflammation as well. Since this can cause pain and can make things hard on you it helps to know what may help. If you want to try this you need only find the foods which contain this bacteria. Yogurt it one example of such foods. That is easily obtained. It is sold at practically every grocery store.
"The studies indicate that this association between fiber intake and anti-inflammatory response may be due to the presence of short-chain fatty acids (SCFAs), which are active byproducts of the fermentation of soluble dietary fiber and resistant starch by bacteria in the colon"
Read more: https://www.medicalnewsbulletin.com/prebiotic-probiotic-systemic-inflammation/
Probiotics a possible treatment for jaundice in newborn babies
August 17, 2017 11:14 AM
Probiotics are being tested as a possible way to treat babies born with potentially fatal jaundice. Studies are still inconclusive as more research and follow up remains necessary. Some babies were noted to experience adverse side effects, while others were not. This disease is rather common, hence adding to the benefit of finding an effective treatment. This study was being done by researchers at Sichuan University. Improvements will be needed for additional research and studies of treating with probiotics.
Read more: Probiotics a possible treatment for jaundice in newborn babies
Organic onions richer in flavonoids
July 08, 2017 12:14 PM
Many studies have tried and failed to successfully prove whether organically grown foods are truly healthier then conventionally grown produce. A six year long study showed that onions grown organically consistently have ten to fifty percent more flavonoids then the conventionally grown onions, however, the difference in the amounts of flavoniods could have been caused by diffences in soil type, pest control or many other variables. Although higher in flavonoids, the studies still are inconclusive whether the higher amount makes the organically grown produce healthier then conventionally grown onions.
"Consistently higher levels of individual flavonoids were also present in the organic onions, and the extracts had higher antioxidant activity in two assays that measure radical scavenging activity."
Read more: http://cen.acs.org/articles/95/web/2017/06/Organic-onions-richer-flavonoids.html
July 08, 2009 10:50 AM
The headline "Doubts over heart claims of omega-3 fats" was published in March of 2006 in the world's largest international news agency, Reuters. This article reported on the findings of a study on omega-3 fats and heart health, which published the exact same month in the British Medical Journal. The article found in Reuters claimed that the systematic review of 89 studies led to the conclusion that there was no substantive evidence that omega-3 fats actually protected individuals against cardiovascular disease or cancer. The New Zealand Herald picked up this article and announced that the heart-healthy advice to eat more oily fish was incorrect, as it advised its readers to put fish oils on the top of the list of medical beliefs that turned out to be myths.
In actuality, the omega-3 investigation, conducted by Lee Hooper and coworkers at the University of East Anglia School of Medicine, was a meta-analysis, as it combined data from several available clinical trials. Meta-analyses are highly speculative due to the differences in the scientific protocols between the included studies, which can lead to difficulty in exposing a common factor. A good meta-analysis is often useful to put contradictory evidence into perspective. However, a poorly designed analysis can lead to bad science and faulty conclusions.
This Hooper analysis was a review of 48 randomized controlled trials, along with 41 cohort studies. However, the investigation only used as few as 15 controlled trials and 3 cohort studies in compiling the data. Included in this analysis were studies that had very small sample sizes and provided little data on the effects under investigation. Extremely low death rates in several of the studies that were included worsened the situation, which resulted in a very large confidence interval and a lower analytical power than what was expected. Additionally, there was a large degree of difference among the included studies. Some of them had death rates in their control groups as low as 0.5%, while others had extremely high control-group death rates exceeding 15% and 22% in two cases. This fact indicates that there were large disparities in the health of subjects. This much heterogeneity among subjects requires a high degree of analytical power in order to produce meaningful results. This was something that the Hooper study lacked.
When addressing the above issues, the authors of the study pointed out that “there were too few events such as deaths, associated cardiovascular events, and incidences of cancer to rule out the possibility of important effects from various interventions.” This basically means that the numbers produced in the study produced results that didn't show much of anything. In a case like this, a person should be extremely cautious as to dismissing a possibly association based on negative results. Dr. Mike Knapton, the Director of Prevention and Care for the British Heart Foundation cautioned the public that they should not stop consuming omega-3 fats or eating oily fish as a result of this study. The wise advice given by Dr. Knapton, however, was not enough to stop the media from fabricating stories and devaluing the necessity for omega-3 fats.
The fact is that omega-3 when taken on a consistent basis can help reduce cholesterol and improve cardiovascular health. Look for high quality omega-3 fish oil that is molecularly distilled at your local or internet health food store. Always select name brands to ensure quality and purity of the product you purchase.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Omega-3 fish oil is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
NHA/Washington Update - Statistics Lie
April 06, 2007 04:57 PM
The mass media targets antioxidants with misleading stats.
The smear campaign against nutritional supplements continues in 2007, with headlines such as the following: “Antioxidants Don’t help You Live Longer,” “Antioxidants Might be Dangerous,” “Antioxidants Do Not Prevent Disease and May Increase Mortality.” Do you notice a theme? Antioxidants are the latest target for media manipulators seeking to steer the public away from life-enhancing nutrition.
The study that spawned these alarmist headlines, first published in the Journal of the American Medical Association, is a “meta-analysis”; this means it draws its conclusions from a number of different studies. In this case, 68 studies involving 232,606 people were analyzed. Meta-analyses are an example of how easily statistics can lie.
Like 2004’s infamous vitamin E-bashing meta-analysis (which proclaimed vitamin E to be deadly, even though it focused on elderly patients who were already stricken with disease), the recent meta-analysis of antioxidants has a preordained outcome—results are determined by which studies are chosen for analysis. Experts have pointed out significant flaws in the execution of this meta-analysis; for example, it includes studies that administered many different combinations of antioxidants, and in varying doses. In addition, these Hitler-skelter antioxidants and dosages are scattered across a wide range of people, everyone from male doctors to elderly nursing home patients. Finally, this meta-analysis neglected to include the most significant antioxidant study ever conducted in its findings. The china study, which in surveying 800 million people was one of the most comprehensive studies of its kind, verified antioxidants effectiveness in fighting cancer, heart disease and stroke. Why was it not included in the meta-analysis?
Even a junior high school science student would question this meta-analysis’s statistical significance. So how can mass media transform this flawed study into headlines that proclaim antioxidants will kill you?
The answer is because the media gets away with it. In our fast paced world, where celebrity rehab stints are front page news, fact-driven journalism is fading—and distracted news readers are enabling its demise. The solution? Consider media reports with awareness and intelligence, and never assume that headlines speak truthfully.
The recent antioxidant bashing study crumbles when subjected to awareness and intelligence. In addition to the obvious study flaws, and even more telling: stories coving the study with headlines proclaiming “antioxidants may increase mortality” are grievously misleading; as it turns out, the study did not identify any causes of death—which were surely diverse given that the study tracked over 200,000 diverse people. Believe the headlines, however, an antioxidants causing all the deaths when in fact they probably caused none—an example of the absurd “association with out causation” logic that may destroy our right to take safe, natural supplements.
Continue investigating and you will find that Denham Harman, MD, PhD, the “father of the free radical theory of aging,” antioxidants pioneer and professor emeritus at the University of Nebraska Medical Center, is able-bodied and active at age 91. Harman takes antioxidants vitamin C, vitamin E and selenium daily—a revelation with more credibility than any antioxidant bashing hatchet-job study.
Educate yourself about antioxidants and other supplements that Congress is trying to take away from you. Fight to keep your health under your own control, always. Patronize the natural health food store that are committed to providing you with quality products and reliable knowledge. For more information, visit www.nha2007.com
Peppermint Oil for IBS
March 24, 2007 11:01 AM
Irritable bowel syndrome (IBS) is a painful and frequently frustrating disorder of the intestines that’s often difficult to treat. Fortunately, there are scientifically studied natural products that effectively reduce the distressing symptoms of IBS.
Q. What is IBS?
A. IBS causes crampy pain, gassiness, bloating, and alterations in bowel habits. IBS is termed a functional disorder, because when the colon is examined, there is no visible sign of disease. While IBS causes significant pain and distress, no actual damage is occurring in the intestines.
There is a wide variability in IBS. Symptoms may be mild and fairly well tolerated. Or, the pain, discomfort, and bowel dysfunction may be disabling, limiting social interactions, employment, or travel.
While some individuals with IBS have diarrhea (frequent, loose stools with an urgent need to move the bowels), others have constipation (hard, infrequent stools that are difficult to pass). And, still others may experience both. Individuals with IBS also may have painful abdominal cramps and feel an urgent need to move the bowels, but are unable to do so.
A. The small intestine receives digestive material from the stomach and delivers it to the large intestine (colon). About two quarts (2,000 ml) of digestive material enter the colon from the small intestine every day. The colon absorbs water and salts from the material, which is progressively moved through the colon. This progressive movement continues until most of the fluid and salts are absorbed into the body and stool is formed. The stool passes to the left side of the colon, where it is stored until a bowel movement occurs.
Because researchers haven’t been able to find actual damage in the colon, it once was suggested that individuals with IBS have emotional problems or are overly susceptible to stress. While stress may cause symptoms of IBS to intensify, it doesn’t cause the condition.
Recent study has determined the colon muscle of an individual with IBS spasms after only mild stimulation. It’s thought the symptoms of IBS are produced by hyperactivity of the intestines. In other words, the intestines of individuals with IBS are more reactive to stressors and diet than usual. Almost everyone has experienced abdominal queasiness in response to everyday stress or certain foods. This may result in a brief bout of diarrhea or an upset stomach. However, this response is exaggerated in individuals with IBS.
Q. How prevalent is IBS?
A. IBS is very common. In fact, it’s one of the most frequent problems seen by family physicians. It’s the most common disorder diagnosed by gastroenterologists (physicians specializing in the treatment of digestive disorders). The overall prevalence rates range from 10% to 20% of the general population in most industrialized countries. As a result, the pain and disabling symptoms associated with IBS result in significant socioeconomic costs, as wall as reduction in quality of life for many individuals.
A. Normal bowel function varies from person to person. Some people move their bowels daily, while others may only have two to three stools a week. A normal bowel movement is soft, formed, and is easily passed without cramping or pain.
IBS, however, causes abdominal cramps and pain, which are often severe and disabling. Bowel movements may be irregular and alternate between diarrhea and constipation. The diarrhea may be quite loose and watery. Mucous may be passed. There is often much straining, urgency, and feeling of incomplete evacuation (emptying). Abdominal bloating and passing of gas is common. Nausea, lack of appetite, heartburn, and belching may also be present. Sleep may be disrupted resulting in fatigue and lack of energy. Understandably, persons with IBS often feel anxious and depressed.
Diagnosis of IBS is usually based on the continuous presence or recurrence of these symptoms for at least three months. Other intestinal conditions must be ruled out. These include Chron’s disease, ulcerative colitis, inflammatory bowel disease, colon cancer, inflammatory conditions of the stomach or pancreas, ulcers, infectious disease, or gastroesphageal reflux disease.
Q. Are there clinically demonstrated natural alternatives to the over-the-counter drugs prescribed by my doctor?
A. Yes, both enteric-coated peppermint oil and clown’s mustard (in combination with other herbs) have significant scientific research behind them. Both have been demonstrated to benefit individuals with IBS.
Q. What is clown’s mustard and what does it do?
A. The scientific name for clown’s mustard is Iberis amara. Other names for this herb are wild candytuft and bitter candytuft. Clown’s mustard is a white-flowering plant from Spain, where it grows in dry soil on hillsides and in cornfields. It is also grown in Britain, France, and the United States. Iberis amara is a member of the Brassicaceae family. Iberis refers to its place of origin, the Iberian Peninsula. Amara means bitter. The key components of clown’s mustard are glycosides and flavonoids that have specific actions on gastrointestinal tract tone.
Q. Is there scientific evidence that clown’s mustard benefits people with IBS?
A. There has been very impressive research on clown’s mustard (in combination with other herbs). And, it has been used with great success in Germany for many years to treat IBS and other gastrointestinal diseases.
In a study of an herbal combination containing clown’s mustard, 20 patients were given the herbal combination for three to 32 days. They all had been diagnosed with chronic functional disorders for at least one to 20 years. The symptoms the patients experienced included pressure and pain in the abdomen, belching, heartburn, vomiting, nausea, fullness, lack of appetite, constipation, and diarrhea. The patients have been treated for their problems with a variety of antacids, anti-spasmodic agents, and motility-inducing substances. For the purposes of the study, the patients stopped taking these medications and received treatment only with the herbal combination.
Abdominal pressure and pain in the abdomen was the most common of all the experienced symptoms, with 11 of the patients rating it as severe. After six days of treatment, only sic of the patients continued to rate their abdominal pain and pressure as severe. After two weeks, this symptom had completely resolved for 16 of the patients. Diarrhea had been rated as severe in five of the patients. By day 14, only one patient continued to have moderate diarrhea.
Medications prescribed and taken for cardiovascular diseases, arthritis, and autoimmune diseases often cause gastrointestinal problems. Because these conditions are chronic, these medications must be taken for a long time, often for life. With long-term use, these medications can cause erosion of the stomach lining and actual ulcers. Many of these medication-caused symptoms are similar to IBS symptoms: pressure and pain in the upper abdomen, nausea, abdominal fullness, and lack of appetite. Most, if not all, of the individuals who have gastrointestinal problems caused from medications experience two or more of these IBS symptoms.
Forty patients who were taking medications for various types of cardiovascular disease and arthritis, and who are experiencing gastrointestinal problems related to their medications, were enrolled in a study. These symptoms included pressure and pain in the upper abdomen, nausea, abdominal fullness, and lack of appetite. Twenty patients received clown’s mustard combined with other herbs that support gastrointestinal motility. Three days after the trial started, a significant improvement of all s symptoms was noted in those taking this combination. By day 14, abdominal pressure and pain, nausea, and heartburn were completely eliminated in the herbal combination group. Several other clinical trials that were conducted in Germany report similar results.
Q. How does this herb compare to prescription drugs?
A. A study compared clown’s mustard (combined with other herbs) to Reglan (metoclopramide), which is frequently prescribed to reduce the symptoms of IBS. While metoclopramide is a very effective medication, it also has numerous side effects. Metoclopramide can cause fatigue, anxiety, agitation, jitteriness, insomnia, yellowing of the skin or eyes, changes in vision, hallucinations, and seizures. Because of these serious side effects, metoclopramide must not be taken longer than 12 weeks.
In comparison study, 77 subjects were randomized to receive treatment of either clown’s mustard in a combination with other herbs, or metoclopramide. All subjects had pain and pressure in the abdomen, cramping, abdominal fullness, nausea, heartburn, and lack of appetite. The subjects took 20 drops of their assigned treatment after meals three times daily. The duration of treatment was one to two weeks.
In both groups, a parallel improvement of all symptoms was observed. At no point in the study was a statistically significant difference in symptoms found. Both treatments significantly reduced pain and pressure in the abdomen, cramping, abdominal fullness, nausea, heartburn, and lack of appetite. In short, both metoclopramide and the clown’s mustard herbal combination worked well at reducing the symptoms of IBS.
However, side effects occurred more frequently and severely in the metoclopramide group. Given the lack of differences noted between the products at reducing symptoms of IBS, it would seem sensible to choose the treatment with the fewest reported side effects and no limits on duration of use.
A. Peppermint oil has been shown to relax intestinal smooth muscle. In Great Britain, peppermint oil is currently being prescribed for IBS by physicians and it has been used as a digestive aid and to soothe upset stomachs for generations.
Peppermint oil has also been studied for use in an important examination of the colon. A colonoscopy is a procedure of viewing the interior lining of the large intestine (colon) using a colonoscope, a slender, flexible, hollow, lighted tube about the thickness of a finger. A study published in the New England Journal of Medicine supports the idea that even people who are not at risk for colon cancer should have this test. The American Cancer Society recommends that men and women at average risk of colon cancer should have a colonoscopy every 10 years, beginning at age 50.
During a colonoscopy, individuals are sedated and almost no discomfort is experienced. The insertion of the colonoscope into the rectum and up through the colon causes some spasming. This is a natural and expected event and the physician performing the exam administers medications that effectively reduce the spasms.
A recent study compared the use of peppermint oil and commonly used medications to reduce the colonic spasming in colonoscopy. The peppermint oil was introduced directly into the colon. Effective reduction of colon spasming was observed in 88% of the patients.
In a critical review and meta-analysis of peppermint oil for irritable bowel syndrome published in The American Journal of Gastroenterology, eight randomized controlled trials were identified. The studies collectively showed peppermint oil is superior to placebo in improvement of the symptoms of IBS. Because of the good results of these trials, the authors of the review urged additional study of peppermint oil in IBS.
However, straight peppermint oil is rapidly absorbed into the blood stream from the stomach. In recent studies comparing enteric-coated peppermint oil capsules and non-enteric coated oil, both preparations provided effective symptom relief. However, the studies concluded the enteric-coated capsules delivered the benefit of the peppermint oil directly to the intestines. In the treatment of IBS, enteric-coated supplemental peppermint is most definitely preferred.
In fact, an enteric-coated peppermint oil capsule containing rosemary and thyme is extremely effective in the treatment of IBS. All three of these oils are classified as volatile oils, derivatives found in plants that impart taste and aroma. The combination of peppermint, thyme, and rosemary oils in enteric-coated capsules provides significant relief in IBS-related pain.
Q. Can clown’s mustard and other herbs be taken with enteric-coated peppermint oil?
A. Yes, peppermint oil capsules and clown’s mustard can be used together. However, depending on the symptoms, individuals with IBS may want to start with one supplement and then add the other if needed.
Q. How do consumers find these formulas?
A. Fortunately, herbal combinations containing clown’s mustard and enteric-coated peppermint oil capsules are both available at health food stores, natural product supermarkets, pharmacies, and from health professionals. Most knowledgeable sales personnel and health professionals can direct consumers to the most effective products.
Q. What should customers look for when purchasing peppermint oil?
A. As mentioned before, enteric coating of the peppermint oil is extremely important. The coating prevents the oil from being absorbed in the stomach. The enteric coated-capsule moves through the stomach to the small intestine and eventually to the colon, where it is released for maximum benefit.
Q. What is the dosage for peppermint oil?
A. The German Commission E approved peppermint oil for the treatment of irritable colon. In enteric-coated form, the Commission E recommends 0.6 ml per day. Enteric-coated peppermint capsules are available.
Q. Are there side effects or other contraindications?
A. Sometimes, the enteric-coated peppermint oil capsules may cause a transient burning sensation in the rectum when moving bowls. Reducing the dose will correct this.
Individuals who must refrain from alcohol should not take clown’s mustard in an herbal tincture, which may contain alcohol.
Q. What else can IBS patients do to feel better?
A. Food allergies or food intolerance may be associated with IBS. Dairy products and certain grains may trigger a painful episode of IBS. Determining those foods that initiate the problems and eliminating them from your diet can be very helpful.
Many people report their symptoms occur after a meal. Hyperactivity of the intestine of IBS is the response. Often, the strength of this response after a meal is in direct relation to the number of calories and he amount of fat in the meal. Reducing saturated fat, limiting calories, and increasing fiber intake may be helpful.
Stress also stimulates the intestinal hyperactivity. Relaxation training may reduce some IBS symptoms. Listening to therapeutic audiotapes, hypnosis, counseling, and biofeedback all have been shown to improve the healing response in persons with IBS.
IBS can be painful and frustrating, capable of causing much distress. While currently there is no cure for IBS, the symptoms can be managed. The pain, abdominal discomfort, and bowel problems of IBS all respond well to treatment with the use of key herbs, including clown’s mustard, and enteric-coated peppermint oil. These herbal combinations can be both effective and safe in treating IBS. Clown’s mustard and enteric-coated peppermint oil are both effective front-line natural alternatives for IBS treatment.
Vitamin D May Show Benefits Against Breast and Colorectal Cancer
February 27, 2007 02:09 PM
Review and meta-analysis of several studies led researchers from several institutions to determine that an increased daily intake of vitamin D may significantly correlate with reduced incidences of colorectal and breast cancer. The breast cancer study pooled dose-response data from two earlier studies of 1,760 subjects. Subjects with the highest serum concentrations of 25-hydroxyvitamin D, or 25(OH)D (50 nanograms per milliliter), had a fifty percent lower risk of breast cancer compared to those with the lowest blood concentrations; less than or equal to 10 nanograms per milliliter. The colorectal cancer meta-analysis looked at fiver studies of 1,448 caucasian subjects. The authors estimate a two-thirds reduction in incidence with serum concentrations of 46 nanograms per milliliter, corresponding to a daily intake of 2,000 IU of vitamin D3. the researchers state the best way to achieve these concentrations is a combination of diet, supplements and 10 to 15 minutes per day in the sun. (Journal of Steroid Biochemistry Medicine, volume 32, Number 3, Pages 210-216)
7-Keto - Anti-Aging and Antioxidant Protection
December 18, 2005 09:44 PM
“Anti-Aging and Antioxidant Protection”
The Fountain of Youth Discovered in Wisconsin
It turns out that Ponce de Leon was looking in the wrong place for the fabled Fountain of Youth. It was recently discovered – in Wisconsin! And it turns out that the Fountain of Youth isn’t really a fountain – it’s a biological compound produced in our own bodies. This compound is extremely important for the growth and development of the human body, and, as the body’s production of this substance decreases with age, the signs of aging begin to appear – weight gain, wrinkled skin, loss of muscle, loss of cognitive function, and loss of libido.
This biological Fountain of Youth was discovered by Dr. Henry Lardy and associates at the Institute for Enzyme Research at the University of Wisconsin. It’s called 7-Keto™, a metabolite of a hormone produced by the adrenal glands called DHEA (dehydroepiandrosterone). Research on 7-Keto™ indicates that it may work through a number of pathways to combat the signs of aging. Helping the body maintain a healthy weight as we age greatly improves overall health and longevity and is one of the strongest benefits discovered for 7-Keto™ to date.
Unfortunately, because 7-Keto™ is a metabolite of DHEA, whose levels decline as we age, so to does this wonderful, natural bio-nutrient. Scientists originally looked to DHEA for improved cardiovascular vitality, and strengthened immune and brain function3. Researchers believed that declining DHEA so profoundly impacted our bodies that it could be partly responsible for the effects of aging. They hypothesized that supplementation with DHEA could sustain hormone levels and stave off many of the degenerative changes we collectively call aging. But there was a catch. Because DHEA is converted into sex hormones, people taking supplemental DHEA would sometimes experience the frightening, unwanted side effects associated with hormone supplementation.
In 1989, Dr. Lardy and his colleagues set out to solve the mystery of eliminating DHEA’s side effects by examining all of the constituents that make up DHEA. Ten long years of research unearthed hundreds of DHEA derivatives, which were developed and tested continuously, until one derivative rose above all the others – a metabolite that was incredibly bio-active and far more promising than any other substance they’d tested. That metabolite is 7-Keto™. 7-Keto™ outperformed DHEA and other metabolites in immune modulation, memory enhancement and thermogenesis and, more importantly, without any adverse side effects3.
The most significant benefit of 7-Keto™ supplementation is its ability to support healthy body weight. Obesity is a major contributing factor in a number of serious medical conditions. A recent study assessed the effectiveness of 7-Keto™ on weight loss and body fat loss. Participants were divided into two groups; one group received 100mg of 7-Keto™ twice daily and the other a placebo. Both groups exercised three times per week. At the end of the study, researchers noted a statistically significant reduction in body weight and body fat only in the 7-Keto™ group. Researchers concluded that 7-Keto™ was three times more effective than diet and exercise alone in promoting weight and fat loss1,2,7. Preliminary research also indicates that 7-Keto™ may support healthy immune and nervous systems. One study measured the effects of 7-Keto™ on memory function. Subjects were given a single dose of a substance that inhibits nerve cell communication and causes shortterm memory loss. Afterwards subjects were given a single dose of 7-Keto™. Results showed that 7-Keto completely reversed the memory impairment, suggesting that 7-Keto™ supports memory retention6.
Another study gauged 7-Keto™’s ability to support immune system function. Interleukin 2 (IL2) is a substance produced by T lymphocytes that causes an increase of disease fighting white blood cells. White blood cells were taken from healthy volunteers and introduced into a solution that contained 7-Keto™ for 24 hours. When the cultures were tested for heightened IL2 production. 7-Keto™ was shown to augment IL2 production by a statistically significant 68%4.
NOW® 7-Keto™ is a well-researched and patented form of this amazing product that’s supplied by the Humanetics Corporation. Humanetics 7-Keto™ has been proven safe and well-tolerated in doses up to 200mg5. Research is clear, the rate at which we age can be influenced by the diet and lifestyle choices we make. One very smart choice would clearly be adding NOW 7-Keto™ to your diet.
1) 7-Keto™: The Key to Healthy Aging – Scientific Support; Humanetics Corporation, 1999
Research on SAMe....
October 26, 2005 12:49 PM
Two groups of researchers have conducted analyses of trials that utilized SAM-e for mood enhancement. One meta-analysis was published in 1994. The researchers analyzed the efficacy of SAM-e in oral or injection forms based on published trials dated between 1973 and 1992. The authors concluded that there was a significant improvement of 17 to 38% seen in trials of SAM-e compared to placebo response. They state that the efficacy of SAM-e was superior to placebo and its administration caused few side effects.5 A second review was published in 2002. The authors analyzed studies in which SAM-e doses ranged from 200 to 1600 mg daily. They also found a significant effect of SAM-e in comparison to placebo, with an evident rapid onset of effect at enhancing mood.6
Promotes Joint Comfort and Mobility*
As a sulfur donor to connective tissue, SAM-e plays a major role in protecting the integrity of cartilage tissue. An in vitro trial assessed the actions of SAM-e in cultured human articular chondrocytes. At a concentration of 10 micrograms/ml, proteoglycan synthesis and sulfate residue incorporation in chondrocytes was shown to be 60% higher than control levels. Based on these results, it was shown that SAM-e has a positive influence on the growth and health of cartilaginous connective tissue.7
In a double-blind trial with 734 individuals with compromised joint health. SAM-e given orally at a dose of 1200 mg daily for 30 days was shown to significantly promote joint comfort compared to placebo, with a high level of tolerability and low incidence of side effects. The researchers concluded that SAM-e is a highly effective supplement for enhancing joint comfort.8
Another trial evaluated the response of individuals experiencing discomfort in the joints to a regimen of 1200 mg SAM-e for 1 week followed by 800 mg for the second week, and then 400 mg for weeks 3 through 8. This open trial of 20, 641 people showed a strong ability of SAM-e to enhance feelings of comfort within the joints. The treatment was rated as “very good” or “good” in 71% of the participants, with an additional 21% rating the treatment effect as “moderate”.9
In a long-term trial lasting 24 months, SAM-e was given to 108 participants with compromised joint function. Individuals were given 600 mg orally per day for the first two weeks followed by 400 mg daily for the remainder of the trial. Individuals experienced significant enhancements in joint comfort, with dramatic improvements noted after 2-4 weeks of treatment. Improvements continued to 6 months and beyond.10
In addition to the above studies, a review was conducted in 1987 to assess the results of SAM-e supplementation in clinical trials for enhancing joint mobility and function. Over 22,000 individuals had participated in the clinical trials that were the subject of this review. The author concluded from his analysis that SAM-e was shown to be highly efficacious, rivaling or surpassing the effectiveness of other treatments, and also possessing a high level of safety.11 Because of this, SAM-e may be the treatment of choice for enhancing joint function.
Supports Liver Health and Detoxification*
SAM-e supplementation can have profound benefits on liver function. These benefits center around its function as the major methyl donor in the liver, as well as its lipotropic activity. SAM-e also enhances the production of the antioxidant glutathione.
A number of trials have been conducted showing the ability of SAM-e to support liver detoxification functions and enhance liver health in individuals susceptible to toxin-induced liver compromise. SAM-e has the ability to normalize liver function by increasing the activity of enzymes needed to upregulate liver detoxification. These effects are comprehensive and rapid. Dosages used in these studies range from 600 mg to 1600 mg daily for 2 months to two years.12,13,14 In these trials, significant benefits of SAM-e supplementation were seen over placebo.
SAM-e has an excellent safety profile and is considered well-suited for long term use based on multiple clinical trials. Individuals diagnosed with manic depression should avoid SAM-e supplementation, as it may aggravate the manic phase *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Agnoli A, Andreoli V, Casacchia M, Cerbo R. Effect of s-adenosyl-l-methionine (SAMe) upon depressive symptoms. J Psychiatr Res. 1976;13(1):43-54.
2. De Leo D. S-adenosylmethionine as an antidepressant. Curr Ther Research. 1987;41(6):865-70.
3. Kagan BL, Sultzer DL, Rosenlicht N,Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 1990 May;147(5):591-5.
4.Salmaggi P,Bressa GM,Nicchia G,Coniglio M,La Greca P,Le Grazie C.Doubleblind, placebo-controlled study of S-adenosyl-L-methionine in depressed postmenopausal women. Psychother Psychosom. 1993;59(1):34-40.
5. Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressant: metaanalysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. 6.Mischoulon D, Fava M. Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. Am J Clin Nutr. 2002 Nov;76(5):1158S-61S.
7. Harmand MF, Vilamitjana J,Maloche E, Duphil R, Ducassou D. Effects of Sadenosylmethionine on human articular chondrocyte differentiation. An in vitro study. Am J Med. 1987 Nov 20;83(5A):48-54.
8. Caruso I, . Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. Am J Med. 1987 Nov 20;83(5A):66-71.
9. Berger R, Nowak H. A new medical approach to the treatment of osteoarthritis. Report of an open phase IV study with ademetionine (Gumbaral). Am J Med. 1987 Nov 20;83(5A):84-8.
10. Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med. 1987 Nov 20;83(5A):89-94.
11. di Padova C. S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies. Am J Med. 1987 Nov 20;83(5A):60-5.
12. Frezza M, et al. S-adenosylmethionine counteracts oral contraceptive hepatotoxicity in women. Am J Med Sci. 1987; 293(4):234-238.
13. Frezza M, Surrenti C, Manzillo G, Fiaccadori F, Bortolini M, Di Padova C. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology. 1990 Jul;99(1):211-5.
14. Mato JM, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol. 1999 Jun;30(6):1081-9.
July 15, 2005 09:52 AM
June 30, 2005 09:20 AM
Depression By Ellen J. Kamhi, Ph. D. with Dorie Greenblatt Depression is a widespread health imbalance that effects many people at some point in their lives, and may be caused by a multifaceted list of factors. Depression can be triggered by personal tragedy, loss of a loved one, or changes in life situations (even if they are positive!). Some of the less recognized causes of depression may involve diet, including over-consumption of sugar, artificial sweeteners, chemical flavorings and preservatives, insufficient nutrition and foods that causes an allergic or sensitivity reaction in an individual. Lack of exercise and not enough sunlight, (i.e. Seasonal Affective Disorder), may be implicated as well. It is essential that those suffering from severe depression seek professional care. Since depression can arise from many different sources and operate on multiple levels, it is helpful to remember that “true healing” requires one to explore and address the root cause(s), not just attempt to cover up the symptom. Proper nutrition is essential. B vitamins can be helpful, such as Nature’s Answer’s B-Stress with Herbs, along with other nutrients such as the amino acids, GABA (particularly for anxiety), Tyrosine and Phenylalanine. Regular exercise, and a nice relaxing bath in lavender oil and sea salt are also enjoyable aids for lifting one’s spirits.
Herbs can be useful in relieving the symptoms of mild to moderate depression. Nature’s Answer offers many high-quality, single herb and combination formulas (liquid or capsule) that feature ingredients well-known for balancing emotional mood. Relora®* features a patented propriety blend of two herbs, Magnolia (standardized to 1.5% honokiol (3.75mg)) and Phellodendron (standardized to 0.1% berberine (0.25mg)) which, when combined according to a particular method, may help reduce the negative effects of stress, a factor that leads to depression as well as “stress overeating”. When the body is under stress, it causes the release of specific “stress hormones” that influence mood and emotional well-being. Relora® is unique because its active plant constituents work on the body’s natural chemistry to re-establish a normal equilibrium of stress hormones, while enhancing feelings of relaxation and cheerful outlook.
Another powerful, “all-in-one” proprietary herbal blend formula from Nature’s Answer® is Mood Balance 2™ (alcohol free liquid, vegetarian capsule). Mood Balance 2™ contains key ingredients well-recognized for their beneficial actions on emotional health, including St. John’s Wort, California Spikenard, Gotu Kola, Skullcap and Eleuthero root**. This combination of ingredients can help “lift the spirits”. (Note that these herbs are also available from Nature’s Answer® as single herb formulas in concentrated liquid herbal extracts and/or vegetarian capsules; Kosher).
Key ingredients in Mood Balance 2™include:
St. John’s Wort (Hypericum perforatum), used for a range of nerve disorders and said to “chase away evil spirits.” Since 1996, it has become one of the most popular herbs in the US due to its use as a mild to moderate antidepressant. A number of current studies confirm its effectiveness, including a review in the British Medical Journal of 23 clinical trials, which reported that it worked nearly as well as the leading pharmaceuticals with far fewer side effects. Although more research is needed, it appears that the activity of St. John’s Wort is due to a variety of naturally occurring components, including Hypericin and Hyperforin. Nature’s Answer’s exclusive formula, Super St. John’s Wort (vegetarian capsule), is standardized to both 3.0% hyperforin and 0.3% hypericin. Gotu Kola (Centella asiatica), used for centuries in Ayurvedic medicine as a nerve tonic and to treat emotional upset, insomnia, stress, anxiety and memory problems. It is currently used along with meditation and yoga due to its abilities to both calm and energize nerves. Skullcap (Scutellaria lateriflora) has the double action of relaxing nervous tension while building the central nervous system. As a mild bitter it will also help stimulate digestion and help the liver. Eleuthero root** (Eleutherococcus senticosus) is an “adaptogen” that helps to balance the entire system. It gives strength and fortitude, especially when dealing with stress; so often a factor in depression.
References for Educational Purposes:
Timed-Release St. John’s Wort Once Daily The Next Generation in Mood Support.
June 29, 2005 09:37 AM
Timed-Release St. John’s Wort Once Daily The Next Generation in Mood Support.
In our high-powered world, countless Americans are searching for a wholesome, natural product to help them maintain a positive outlook and sense of well-being. The remarkable botanical, St. John’s wort, is well-known for its established history of safe use. Now Source Naturals offers you the first and only once-daily, TIMED-RELEASE ST. JOHN’S WORT. This premium botanical is manufactured in a special cellulose base, which is tested to release St. John’s wort over a 12-hour period.
Source Naturals tests each production lot of TIMED-RELEASE ST. JOHN’SWORT. This exclusive supplement is standardized to 0.3% hypericin, yielding 2.7 mg in every convenient daily dose— the amount shown in research to support mild to moderate maintenance of a positive mood. At a time when our emotional well-being is challenged by unprecedented stress levels, research into the most convenient and effective natural remedies is critical. Source Naturals is your connection to this research, dedicated to quickly bringing you the benefts of the latest emerging wellness strategies.
Popular Choice For a Positive Mood—Now Even Better!
St. John’s wort, or Hypericum perforatum, has been valued by diverse cultures as far back as the Middle Ages for its ability to support a positive outlook and sense of well-being. Today modern consumers are experiencing the benefits of this renowned herb, which include mood-brightening, relaxation, alertness, and a sense of overall well-being. Unlike other supplements on the market, Source Naturals TIMED-RELEASE ST. JOHN’SWORT is produced using the most advanced scientific methods. The result is a supplement that offers the once-daily convenience today’s consumers have come to expect.
A review of 23 randomized clinical trials encompassing 1757 subjects was reported in the British Medical Journal. It showed that St. John’s wort was more effective than placebo for mild to moderate maintenance of a positive mental outlook.
The Beneficial Constituents
The beneficial constituents of the St. John’s Wort plant are believed to be the naphthodianthrones, especially hypericin and pseudohypericin, and a wide variety of flavonoids. Source Naturals TIMED-RELEASE ST. JOHN’S WORT is standardized to consistently yield 0.3% hypericin. Each convenient once-daily dose contains 900 mg of St. John’s Wort extract, yielding 2.7 mg hypericin. This is the optimal amount found in most studies to support a positive outlook and sense of wellbeing. Benefits may be experienced within 4 to 6 weeks of initial use.
Emotional Well-Being: Important Component of the Wellness Revolution
Source Naturals is pleased to join with your local health food store in offering you the next generation in St. John’s wort supplementation. TIMED RELEASE ST. JOHN’SWORT can help you support a positive mood with the remarkable properties of the plant world, exclusively formulated for once-daily convenience. This advanced product reflects today’s revolution in natural health care, offering you the benefits of natural, cuttingedge supplementation.
Garlic for Treating Hypercholesterolemia - A Meta-Analysis ...
May 12, 2005 12:44 PM
Garlic for Treating Hypercholesterolemia - A Meta-Analysis of Randomized Clinical Trials
DATA SOURCES: Systematic literature searches were conducted on the MEDLINE, EMBASE, BIOSIS, Cochrane Library, AMED, and CISCOM databases. Manufacturers of commercial garlic preparations and experts in the field were asked about published or unpublished trials.
STUDY SELECTION: Selected trials were required to state that they were randomized, double-blind, and placebo-controlled; use garlic monopreparations; include persons with mean total cholesterol levels of at least 5.17 mmol/L (200 mg/dL); and report total cholesterol level as an end point. There were no language restrictions.
DATA EXTRACTION: Two reviewers, blinded to key identifiers of each paper, independently extracted data in a standardized manner and assessed methodologic quality by using the Jadad scale. Discrepancies were settled through discussion.
DATA SYNTHESIS: In the 13 trials included in the meta-analysis, garlic reduced total cholesterol level from baseline significantly more than placebo (P < 0.01); the weighted mean difference was -0.41 mmol/L (95% CI, -0.66 to -0.15 mmol/L) (-15.7 mg/dL [CI, -25.6 to -5.7 mg/dL]). Six diet-controlled trials with the highest scores for methodologic quality revealed a nonsignificant difference between garlic and placebo groups; the weighted mean difference was -0.11 mmol/L (CI, -0.30 to 0.08 mmol/L) (-4.3 mg/dL [CI, -11.7 to 3.1 mg/dL]).
CONCLUSIONS: The available data suggest that garlic is superior to placebo in reducing total cholesterol levels. However, the size of the effect is modest and the robustness of the effect is debatable. The use of garlic for hypercholesterolemia is therefore of questionable value.
Garlic as a Lipid Lowering Agent-A Meta-Analysis
May 12, 2005 12:20 PM
Garlic as a Lipid Lowering Agent-A Meta-Analysis