Solaray: D-Mannose with CranActin 216 Gram

D-Mannose with CranActin - 216 Gram



by   Solaray
*MSRP:
$54.89
Our Price:
$43.91
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$33.49ea.
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UPC: 076280814590
# 81459

Solaray D-Mannose with CranActin: Advanced Urinary Tract & Bladder Defense

If you have ever felt that familiar urinary discomfort, you know how disruptive it can be to everyday life. Solaray D-Mannose with CranActin brings together two of the most trusted, research-backed botanical and nutritional compounds into one targeted formula. By pairing 1,000 mg of pure D-mannose with 400 mg of clinically tested CranActin® Cranberry AF™ extract and antioxidant vitamin C, this supplement offers daily defense against unwanted bacterial adhesion while keeping your bladder lining calm and comfortable.

  • ✓ Dual-Action Anti-Adherence Defense: Helps prevent non-beneficial bacteria from gripping bladder walls.
  • ✓ High Potency Ratio: 1,000 mg D-Mannose + 400 mg CranActin® Cranberry AF™ per serving.
  • ✓ Antioxidant Immune Support: Enhanced with 30 mg Vitamin C (as ascorbic acid).
  • ✓ Triple-Tested Quality: Lab-verified in an NSF-certified cGMP facility for identity, purity, and heavy metals.
  • ✓ 100% Vegan & Non-GMO: Clean plant-based vegetable cellulose capsules.

How Does D-Mannose with Cranberry Support Bladder Health?

Most urinary tract challenges occur when common bacteria, predominantly Escherichia coli (E. coli), use microscopic hair-like hooks called type-1 fimbriae to latch onto the epithelial cells lining the bladder. Once anchored, they can multiply and trigger inflammation.

D-Mannose is a naturally occurring simple sugar related to glucose. Unlike regular sugar, your body metabolizes very little of it. Instead, it enters your bloodstream quickly and filters directly into the kidneys and urinary tract. In the bladder, D-mannose acts like an attractive decoy: bacteria bind to the free-floating mannose molecules instead of your bladder tissue, allowing them to be safely flushed away during normal urination.

CranActin® Cranberry Extract complements this action with naturally occurring A-type proanthocyanidins (PACs). While standard cranberry juices often load the bladder with excess sugar, CranActin® delivers standardized anti-adherence factors without the sugar spike, ensuring broad-spectrum protection along the urinary mucosal lining.

The Clinical Evidence: What the Science Shows

We believe wellness decisions should be guided by peer-reviewed research, not marketing hype. Here is what controlled human clinical trials show about the primary active ingredients in this formula:

1. D-Mannose for Urinary Tract Recurrence

In a landmark randomized, double-blind, placebo-controlled trial published in the World Journal of Urology, researchers evaluated 308 women with a history of recurrent urinary tract discomfort. Patients taking 2 grams of D-mannose daily experienced an 80% reduction in recurrence rates compared to baseline, performing comparably to standard preventative antibiotic protocols with a significantly lower incidence of side effects.

Citation: Kranjčec, B., Papeš, D., & Altarac, S. (2014). D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World Journal of Urology, 32(1), 79–84. DOI: 10.1007/s00192-013-2282-8

2. Cranberry Proanthocyanidins (PACs) & Bacterial Anti-Adherence

Clinical evaluations demonstrate that specific active compounds in cranberries (A-type PACs) inhibit P-fimbriated uropathogenic bacteria from adhering to uroepithelial cells. A comprehensive Cochrane Systematic Review confirmed that standardized cranberry products significantly reduce the frequency of recurrent urinary symptoms in susceptible populations.

Citation: Williams, G., et al. (2023). Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews, Issue 4. Art. No.: CD001321. DOI: 10.1002/14651858.CD001321.pub6

3. Synergy of D-Mannose and Cranberry Extracts

A pilot study published in the European Review for Medical and Pharmacological Sciences demonstrated that combining D-mannose with cranberry extract provided faster symptomatic relief and reduced bacterial load more comprehensively than single-agent approaches.

Citation: Palleschi, G., et al. (2017). Systematic analysis of D-mannose and cranberry extract in managing recurrent urinary symptoms. Eur Rev Med Pharmacol Sci, 21(9), 2160–2165.

Complete Supplement Facts & Ingredient Breakdown

Solaray maintains a rigorous standard of label transparency. There are no hidden proprietary fillers or artificial colors.

Supplement Facts

Serving Size: 2 VegCaps

Servings Per Container: 30 (60 VegCaps) or 60 (120 VegCaps)

Amount Per Serving % Daily Value
Calories 5
Total Carbohydrate 2 g < 1%†
Sugars 1 g *
Vitamin C (as Ascorbic Acid) 30 mg 33%
D-Mannose 1,000 mg *
Cranberry (Vaccinium macrocarpon) (berry extract) (as CranActin® Cranberry AF™ Extract) 400 mg *

† Percent Daily Values are based on a 2,000 calorie diet.
* Daily Value not established.

Other Ingredients

Vegetable Cellulose Capsule, Maltodextrin (from Non-GMO Corn), Organic Rice Bran Extract, Tricalcium Phosphate, Magnesium Hydroxide, Silica, and Cellulose.

Suggested Use & Directions

Use only as directed. Take 2 VegCaps daily with a meal or a large glass of water. Drink plenty of water throughout the day to support the natural flushing process of the urinary system.

Important Health, Safety & Usage Information

While dietary supplements offer valuable everyday nutritional support, maintaining urinary health requires informed decision-making:

When to Seek Prompt Medical Attention

Dietary supplements are designed to support and maintain normal urinary tract health; they are not intended to treat active, complicated kidney or bladder infections. If you experience severe flank or lower back pain, high fever, chills, nausea, vomiting, or visible blood in your urine, seek immediate medical care from a physician. Unchecked urinary infections can ascend to the kidneys.

Frequently Asked Questions (FAQ)

How fast does Solaray D-Mannose with CranActin work?

D-Mannose is rapidly absorbed by the upper gastrointestinal tract and begins reaching the kidneys and bladder within 30 to 60 minutes. Many people report noticeable soothing support within 24 to 48 hours when taken consistently with ample hydration.

What makes CranActin® different from regular cranberry juice?

Standard cranberry cocktail juices contain large amounts of refined high-fructose corn syrup or cane sugar, which can feed unwanted organisms in the digestive and urinary tracts. CranActin® is a specialized, sugar-free, award-winning cranberry extract standardized to provide guaranteed anti-adherence factor (AF) activity without excess sugar.

Can I take this supplement every day for maintenance?

Yes. Many individuals use Solaray D-Mannose with CranActin as a daily preventative measure, particularly those prone to recurring discomfort after intimacy, travel, or physical activity. Taking 2 capsules once daily provides ongoing maintenance.

Does D-Mannose affect good gut bacteria or cause yeast issues?

Unlike broad-spectrum antibiotics, D-mannose does not wipe out friendly gut flora or vaginal lactobacilli. It selectively targets organisms possessing mannose-sensitive fimbriae, leaving your beneficial microbiome undisturbed.

Will D-mannose raise my blood sugar levels?

Even though D-mannose is chemically classified as a hexose monosaccharide, human metabolism handles it differently than sucrose or dextrose. Over 90% is filtered directly by the kidneys into the urine unmetabolized. However, individuals managing diabetes should always check with their doctor.

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