SearchBox:

BackRefresh

Cinnamon may lower blood sugar...

old message Cinnamon may control sugar levels... Darrell Miller 07/08/05


PreviousNextListen To An Article On Cinnamon may control sugar levels...

Date: July 08, 2005 10:48 AM
Author:
Subject: Cinnamon may control sugar levels...

Best Cinnamon

  • Use as Part of Your Diet to Help Maintain a Healthy Blood Sugar Level*
  • HUMAN CLINICAL TRIALS
  • Cinnamon,
    a staple ingredient in apple pie, has remained one of the
    world's favorite spices throughout recorded history. The
    evergreen cinnamon tree (Cinnamomum verum), considered to be
    true cinnamon, is native to Sri Lanka. Chinese cinnamon
    (Cinnamomum cassia or Cinnamomum aromaticum), the cinnamon most
    commonly sold in the U.S., goes by the name “Cassia.” Usage of
    cinnamon in Chinese medicine is said to date back over 4,000
    years. Mentioned in the Bible, cinnamon was imported to Egypt
    and Europe from the Far East by 500 B.C. In addition to its
    value as culinary spice, cinnamon has traditionally been
    utilized as a folk medicine for colds and minor digestive
    complaints. True cinnamon and cassia are very similar; cassia
    has a more pungent flavor. Cassia buds can be found in potpourri
    and used as a flavoring agent in sweets and
    beverages.1

    Recent research has revealed that constituents in
    cinnamon bark called procyanidin Type-A polymers help maintain
    the body's ability to metabolize glucose in a healthy way.* Best
    Cinnamon Extract is Cinnulin PF®, a patented, water extract of
    Cinnamon that contains Type-A polymers. Cinnulin PF® is a
    registered trademark of Integrity Nutraceuticals International
    and is manufactured under US Patent #
    6,200,569.

    Benefits

    Use as Part of Your Diet to Help
    Maintain a Healthy Blood Sugar Level*

    In Vitro and Animal
    Studies

    Research has revealed that a number of herbs and
    spices have insulin-like activity.2 In a study by the U.S.
    Department of Agriculture (USDA), cinnamon demonstrated the
    greatest ability to stimulate cellular glucose metabolism among
    49 botanicals tested.3

    In a 2001 study, researchers at the
    USDA's Human Nutrition Research Center showed that bioactive
    compounds in cinnamon trigger an insulin-like response in fat
    cells.4 These compounds stimulated glucose uptake into cells and
    increased glycogen (stored glucose) production via activation of
    the enzyme, glycogen synthase.

    The bioactive compounds in
    cinnamon appear to potentiate insulin activity at the level of
    the cell receptor for insulin. It has been shown that insulin
    resistance involves down regulation of “insulin signaling”
    characterized by dephosphorylation of the receptor.5 Enzymes
    called “protein tyrosine kinases” (PTPases) are believed to
    decrease receptor phosphorylation, and increased PTPase activity
    has been observed in insulin resistant rats.6 Cinnamon compounds
    have demonstrated the in vitro ability to inhibit PTP-1 and
    increase autophosphorylation of the insulin receptor.7

    In a
    recent animal study, cinnamon (cassia) extract was administered
    to rats for three weeks. Following this, the rats were infused
    with insulin and glucose to assess their insulin response.
    Increased phosphorylation of the insulin receptor was observed
    in skeletal muscle of these rats, suggesting that cinnamon has
    the ability to potentiate insulin function by normalizing
    insulin signaling, leading to improved uptake of glucose into
    skeletal muscle.8

    Until recently, the precise molecular
    structure of the bioactive compounds in cinnamon had not been
    clearly defined. The USDA has now determined that the bioactive
    compounds in cinnamon are water-soluble procyanidin Type-A
    polymers of catechin and epicatechin. In a 2004 study, type-A
    polymers were isolated from cinnamon and characterized by
    nuclear magnetic resonance and mass spectroscopy. Type-A
    polymers were found to increase in vitro insulin activity by a
    factor of 20. Type-A polymers also exhibited antioxidant
    activity, as measured by inhibition of free radical production
    in platelets. These results suggest that, in addition to
    regulating glucose metabolism, cinnamon may help protect cell
    membranes by controlling the lipid peroxidation associated with
    disruptions in insulin function.9

    HUMAN CLINICAL TRIALS

    The effect of cinnamon on glucose and blood lipids
    levels on people with type 2 diabetes was tested in a recent
    randomized, placebo-controlled trial. A total of 60 subjects
    were divided into six groups administered 1, 3, or 6 grams of
    cinnamon daily, in 500 mg capsules, or equal numbers of placebo
    capsules.

    The cinnamon or placebo capsules were consumed for
    two periods of 20 days each. Serum glucose, triglyceride,
    cholesterol, LDL cholesterol and HDL cholesterol were measured
    after 20 days, 40 days and again at the end of a 20-day wash-out
    period, during which neither cinnamon nor placebo was
    consumed.

    In all three cinnamon groups, statistically
    significant reductions in blood glucose levels occurred, with
    decreases ranging from 18 to 29 percent. Interestingly, glucose
    levels remained significantly lower after the 20-day wash-out
    period (60 days from the study start) only in the group that
    took the lowest cinnamon dose (1 gram daily). The placebo groups
    showed no significant changes.

    Decreases in triglyceride
    levels ranging from 23 to 30% were observed in all three
    cinnamon groups after 40 days. When the study ended at 60 days,
    triglyceride levels remained lower than at the study start in
    the 1 and 3 gram cinnamon groups, but not in the group taking 6
    grams daily. Cholesterol reductions also occurred with the three
    cinnamon doses, with decreases ranging from 13 to 25% that were
    maintained at the study end. For LDL, the 3 and 6 gram cinnamon
    groups showed significant reductions from 10 to 24%, while in
    the 1 gram cinnamon group, non-significant reductions occurred
    after 40 days; LDL levels continued to decrease, reaching
    statistical significance at 60 days. With respect to HDL,
    significant increases were seen only in the 3 gram cinnamon
    group after 20 days; non-significant changes occurred in the 1
    and 6 gram groups after 40 days.

    The overall results of this
    trial demonstrate that cinnamon exerts a beneficial effect on
    blood glucose and lipid levels in people with type 2 diabetes,
    at daily intakes of 1 gram, and that this low dose is equally
    efficacious as are the higher doses of 3 and 6
    grams.10

    Safety

    The various species of cinnamon are
    classified as GRAS (generally regarded as safe) herbs.11 The
    Botanical Safety Handbook lists Cinnamomum cassia a “Class 2b”
    herb; not to be used during pregnancy.12 The water-soluble
    cinnamon extract is largely free of the lipid-soluble components
    of cinnamon most likely to be toxic at high dose of cinnamon and
    long-term consumption of the herb.9

    *This statement has not
    been evaluated by the Food and Drug Administration. This product
    is not intended to diagnose, treat, cure or prevent any
    disease.

    Scientific References

    1. Manniche, L. An Ancient
    Egyptian Herbal. 1989, Austin , TX : University of Texas
    Press.

    2. Khan A, Bryden NA, Polansky MM, Anderson RA.
    Insulin potentiating factor and chromium content of selected
    foods and spices. Biol Trace Elem Res 1990;24(3):183-8.

    3.
    Broadhurst CL, Polansky MM, Anderson R. Insulin-like biological
    activity of culinary and medicinal plant aqueous extracts in
    vitro. J Agric Food Chem 2000;48(3):849-52.

    4. Jarvill-Taylor
    KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from
    cinnamon functions as a mimetic for insulin in 3T3-L1
    adipocytes. J Am Coll Nutr 2001;20(4):327-36.

    5. Nadiv O,
    Shinitzky M, Manu H, et al. Elevated protein tyrosine
    phosphatase activity and increased membrane viscosity are
    associated with impaired activation of the insulin receptor
    kinase in old rats. Biochem J. 1998;298(Pt 2):443-50.

    6.
    Begum N, Sussman KE, Draznin B. Differential effects of diabetes
    on adipocyte and liver phosphotyrosine and phsophoserine
    phosphatase activities. Diabetes 1991;40(12):1620-9.

    7.
    Imparl-Radosevich J, Deas S, Polansky MM, et al. Regulation of
    PTP-1 and insulin receptor kinase by fractions from cinnamon:
    implications for cinnamon regulation of insulin signalling. Horm
    Res 1998;50:177-182.

    8. Qin B, Nagasaki M, Ren M, et al.
    Cinnamon extract (traditional herb) potentiates in vivo
    insulin-regulated glucose utilization via enhanced insulin
    signaling in rats. Diabetes Res Clin Pract
    2003;62(3):139-48.

    9. Anderson R, Broadhurst CL, Polansky MM,
    et al. Isolation and characterization of polyphenol type-A
    polymers from cinnamon with insulin-like biological activity. J
    Agric Food Chem 2004; 52(1):65-70.

    10. Khan A, Safdar S,
    Muzaffar M, et al. Cinnamon improves glucose and lipids of
    people with type 2 diabetes. Diabetes Care
    2003;26(12):3215-18.

    11. Duke, JA. Handbook of Phytochemical
    Constituents of GRAS Herbs and Other Economic Plants. 1992. Boca
    Raton, FL: CRC Press.

    12. Botanical Safety Handbook. American
    Herbal Products Association. McGuffin M, et al., eds. 1997; Boca
    Raton , FL : CRC Press.

    Acting as a biochemical
    "super-thiamin," it does this through several different cellular
    mechanisms, as discussed below.



    --
    Vitanet ®







    Guarantee: VitaNet® LLC Offers a 100% Satisfaction Guaranteed!



    VitaNet ® LLC. Discount Vitamin Store.
    --->