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  Messages 1-17 from 17 matching the search criteria.
Green Tea Extracts: The Best Source of EGCG for Cognitive Health, Cellular Defense, and Mental Well-being Darrell Miller 4/25/22
Drinking chilled yerba mate can help you achieve your weight loss goals Darrell Miller 7/27/18
How to eat to get lean Darrell Miller 1/4/17
GUGGUL EXTRACT Darrell Miller 5/5/14
What is Xylitol? Darrell Miller 2/9/14
Health Benefits Of Taking L-Carnitine Darrell Miller 11/4/13
Raspberry ketone for weight loss Darrell Miller 6/11/12
How DoesTurmeric Help Improve Your Health? Darrell Miller 3/22/12
What is Forskoline and How Does It Help You Loose Weight? Darrell Miller 2/9/12
How Does N-Acetyl L-Carnitine Help Energy Levels? Darrell Miller 8/3/11
GABA Darrell Miller 8/26/08
Free Form Amino Acids Promote Fat Loss! Darrell Miller 9/7/06
Ergopharm Dietary Supplements Darrell Miller 7/29/06
7-Keto - Anti-Aging and Antioxidant Protection Darrell Miller 12/18/05
REFERENCES Darrell Miller 6/25/05
MECHANISMS OF CHITOSAN FAT- BINDING Darrell Miller 6/25/05
Building the Burn Darrell Miller 6/14/05




Green Tea Extracts: The Best Source of EGCG for Cognitive Health, Cellular Defense, and Mental Well-being
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Date: April 25, 2022 04:27 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Green Tea Extracts: The Best Source of EGCG for Cognitive Health, Cellular Defense, and Mental Well-being

Green tea is one of the most popular beverages in the world, and for good reason. It has a delicious flavor and offers a variety of health benefits. One of the most beneficial compounds found in green tea is epigallocatechin gallate (EGCG), a catechin polyphenol that has been extensively studied for its positive effects on cognitive health, cellular defense, metabolism, and mental well-being. We will take a closer look at EGCG and discuss why it is such an important compound for optimal health.

What is EGCG

EGCG is short for epigallocatechin gallate, a type of polyphenol that is found in green tea. In addition to its potential health benefits, EGCG is also a powerful antioxidant. Studies have shown that it can help to protect cells from damage caused by free radicals. EGCG has also been shown to boost metabolism and reduce inflammation. Furthermore, some research suggests that it may even have cancer-fighting properties. While more studies are needed to confirm these effects, EGCG is a promising compound with a wide range of potential applications.

How does it work in the body

EGCG is a polyphenol compound that is found in high levels in green tea. Polyphenols are a type of phytochemical, which are plant-based chemicals that have a number of health-promoting properties. EGCG is the most abundant polyphenol in green tea, and it is thought to be responsible for many of the health benefits associated with green tea consumption. In the body, EGCG can bind to certain enzymes and proteins, preventing them from performing their normal functions. For example, EGCG has been shown to inhibit the activity of angiogenesis, which is the growth of new blood vessels. This may explain why green tea consumption has been linked with lower rates of cancer and cardiovascular disease. Additionally, EGCG has been shown to boost metabolism and promote fat loss. However, more research is needed to confirm these effects in humans. Overall, EGCG appears to be a potent phytochemical with a wide range of potential health benefits. Further research is needed to fully understand its mechanisms of action and therapeutic potential.

Why is it important for health and longevity

Epigallocatechin-3-gallate (EGCG) is the most active and abundant catechin in tea. It is a polyphenol that has attracted much attention for its potential health benefits, which include cancer prevention, cardiovascular protection, and neuroprotection. EGCG has also been shown to boost metabolism and promote weight loss. In addition, EGCG has been linked with longevity. Studies in both animals and humans have shown that EGCG can increase lifespan and protect against age-related diseases. These findings suggest that EGCG may be an important key to health and longevity.

The benefits of EGCG

  • -EGCG is a powerful antioxidant that can help protect cells from damage caused by free radicals
  • -EGCG has been shown to boost metabolism and reduce inflammation
  • -EGCG may even have cancer-fighting properties
  • -EGCG is a potent phytochemical with a wide range of potential health benefits
  • -Further research is needed to fully understand its mechanisms of action and therapeutic potential
  • -EGCG can increase lifespan and protect against age-related diseases
  • -Incorporating more green tea into your diet or lifestyle may have numerous health benefits.

Below are some FAQs that might help:

Q: How much green tea should I drink per day?

A: It is recommended to drink three to five cups of green tea per day to reap the most benefits.

Q: What are some good ways to add green tea into my diet?

A: You can add green tea to your diet by drinking it as a beverage, taking green tea supplements, or adding matcha powder to smoothies or baking recipes.

Q: What are some of the possible side effects of green tea?

A: Green tea is generally safe for most people, but it can cause digestive issues in some individuals. It is also important to note that green tea contains caffeine, so it should be consumed in moderation if you are sensitive to this stimulant.

Free Radical Damage and Green Tea

Free radicals can damage cells, which can lead to health problems over time. You know that free radicals are bad for you, but what can you do about them?

Green tea with EGCG is a great way to protect yourself from the damaging effects of free radicals. EGCG is a powerful antioxidant that can help protect cells from damage caused by these harmful molecules.

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Drinking chilled yerba mate can help you achieve your weight loss goals
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Date: July 27, 2018 09:53 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Drinking chilled yerba mate can help you achieve your weight loss goals





Drinking chilled yerba mate can help you achieve your weight loss goals

Consuming chilled yerba mate can enable humans to burn over 50% more calories than they would without drinking it! This boost in energy expenditure not only relates to more fat loss, but it also helps regulate and improve the cardiovascular system. A study that included 23 participants concluded these findings, showing just how beneficial the consumption of chilled yerba mate is much more useful to the body than simply consuming hot varieties of herbal teas.

Key Takeaways:

  • A drink needs to reach your body's natural temperature in order to digest it as is. When something is colder, it burns energy while digesting the product.
  • Not only can yerba mate help decrease body fat when you have it cold, but it also contains much less sugar than other tea drinks.
  • The antioxidant properties that are present within yerba mate will still be contained when it is in a chilled form.

"Data from the study showed that iced yerba mate tea produced over 50 percent more energy expenditure, or calorie burning, versus hot tea, or 8.3 percent compared to 3.7 percent."

Read more: https://www.naturalnews.com/2018-06-14-drinking-chilled-yerba-mate-can-help-you-achieve-your-weight-loss-goals.html

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How to eat to get lean
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Date: January 04, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: How to eat to get lean





Do you love food but want to lose some inches off your waistline? Let me tell you, this is the article for you. Whether you want to lose fat or build muscle, this article will provide you some insight as to how to accomplish your goals without sacrificing your love of food.

Key Takeaways:

  • Drink water like a fish. Drinking water is associated with faster fat loss and decreased hunger. Even a small level of dehydration can decrease physical and mental performance.
  • Multiply your current body weight in pounds by 10. That is the healthy calorie deficit for most moderately active guys.
  • A study last year in PLOS Medicine found the most beneficial vegetables for weight loss were the non-starchy kinds such as lettuce, asparagus, broccoli, cauliflower, cucumber, spinach, peppers, and tomatoes.

"We’re going to shoot it straight: Cutting calories is going to really suck for the entire first week."



Reference:

//www.mensfitness.com/nutrition/what-to-eat/how-eat-get-lean

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GUGGUL EXTRACT
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Date: May 05, 2014 07:40 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GUGGUL EXTRACT

guggul gum extractObese and overweight

With busy schedules day in and day out, refined foods and drinks have become the order of the day and this has led to a higher percentage of people who are obese and overweight. People have realized how this is hurting them and are very concerned about their health and are taking keen interest in how the body works and what it needs to remain healthy and in good shape. Most body processes are driven by hormones, which trigger the necessary reactions.

Thyroid

The body usually produces these hormones but at times, they need external boosting through intake of certain foods or medication. The T3 thyroid hormone is very important as it is responsible for stimulation of metabolism which if one is trying to lose weight is very important. Most people take thyroid drugs to increase this hormone level but a better and natural way is by using guggul extract, which does not have side effects like insomnia, jitters and heart palpitations.

What is a guggul extract and its benefits

Guggul extract is yellowish in color and it comes from guggul (gum guggul) which is a resin that comes from the mukul mirth tree. It possesses bioactive compounds from its sterols. Guggul has been used to treat obesity, acne, inflammation and hypolidemia. Guggul works by converting T4 into T3 triiodothyronine, which is more active in speeding up metabolism. The conversion increases the amount of T3 in the blood stream. The sterols in the extract also boost thyroid stimulating hormone production, which is more direct.

This extract is best used by lose on fat loss diets as it helps maintain high levels of active thyroid which in turn helps in faster burning of the body fat. Remember dieters usually have low calorie intake and the body is designed to slow down metabolism when there is slow food intake so guggul helps crank it up.

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What is Xylitol?
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Date: February 09, 2014 08:50 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What is Xylitol?

What is Xylitol?

xylitolXylitol is a 5-carbon Sugar alcoholic recognized even more particularly like a polyalcohol (polyol) and it has already been getting used because the 60's. You can find this within nourishments with regard to unique nutritional reasons as well as a number of without having Sugar goodies, candy, mints as well as biting down hard gums.

Never such as additional designed sweeteners, for instance, sorbitol, mannitol xylitol assists an all natural flavor and it has absolutely no after-taste. This particular organic sweetener additionally statements in order to help fat loss since it offers forty % less calories from fat compared to Sugar. Due to the reduced glycemic report worth associated with simply 7, this particular Sugar alcoholic beverages has developed into well-liked choice along with diabetes or even people with hypoglycaemia. It's minimum effect on blood sugar levels as well as doesn't assist insulin in order to metabolize. Some of the greatest recognized wellsprings of the Sugar alternative tend to be fruits, mushrooms, as well as lettuce.

In spite of, actually these types of sustenances most abundant in raised levels include only a fragile quantity of the actual Sugar. For example, 1 cup associated with raspberries consists of simply not precisely 1 gram from it. Appropriately, this particular Sugar alternative is actually in a commercial sense ready with the hydrogenation associated with wooden Sugar (zylose) deduced in the xylan hemicellulose polymer bonded present in hardwoods, hammer toe husks, birch trees and shrubs, oats, nutshells, and so forth. The entire chemical substance process is actually vitality severe as well as big size, consequently causeing this to be Sugar alcoholic beverages 10 occasions more expensive compared to desk Sugar, sucrose.

Additionally, I have to stipulate which around it's producer statements which it's 100% organic Sugar, the way in which this particular sweetener may be handled as well as changed in order to draw out the actual Sugar deposits certainly merely does not seem because wholesome or even an amazing identical to something which normally occurs within meals developed in the floor, is not which correct? It is just difficult to think about this a proper Sugar whenever it's already been therefore extremely dealt with.

Is Xylitol Safe?

Indeed, the actual FDA offers mentioned which Xylitol is actually secure with regard to human being usage within never-ending amounts. The primary threat may be the concern associated with Xylitol as well as young puppies. Don't allow your dog consume Xylitol as it might result in a unexpected as well as possibly deadly decrease within dog sugar!

What exactly are Xylitol's Many benefits?

1. It is normally fairly sweet without any unusual aftertaste

2. Appears & preferences such as Sugar

3. 40% less calories from fat & 75% much less carbohydrates compared to Sugar

Xylitol's Dental & Dental care Advantages

Xylitol represses the power associated with germs to stick to tissue within the mouth area as well as can't be digested through germs, therefore it significantly shells from the procedure which produces dangerous, enamel-eating acids.

1. No cario-genic (doesn't trigger cavities)

2. Reduces cavities through 80%

3. Substantial long term reduction in cavities (88-93%)

4. Reduces dental care plaque development through producing plaque much less adhesive

An additional well-known wellness declare of the Sugar is actually it's capability to homicide germs and steer clear of teeth rot as well as dental illness. It's also believed to assist reduce plaque as well as impede current cavities through decreasing. Like the majority of Sugar alcohols, it may change the calm laxative effect from higher dimensions. Based on research brought within 1977, spending 1. four oz . from the Sugar alcoholic beverages for each day time may cause diarrhoea in several topics. It's producer announced which within doses associated with bigger than 15 gr, that is around 3 teaspoons, the actual sweetener isn't secure for everyone to make use of. Diagnostic tests exposed which 1. 65 gr from it might lead to passing away inside a 100gram rat. An average little bit of xylitol-gum consists of 0. 7 -- 1 gram associated with xylitol, and therefore about 50 % the quantity of the actual sweetener is needed to perform the rat.

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Health Benefits Of Taking L-Carnitine
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Date: November 04, 2013 07:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Health Benefits Of Taking L-Carnitine

 What is L –Carnitine

l-carnatineL –Carnitine is an amino acid that is naturally produced in the body. It is found in two different amino acids; methionine and lysine. Dietary sources of this amino acid include pork, beef and small amounts of milk, chicken and fish. This amino acid is highly required by the body and the following are the health benefits of Carnitine.

Important in the management of heart conditions

Carnitine is important in the management of a number of heart related conditions for example congestive heart failure, diphtheria, chronic chest pain, heart attack and high cholesterol. Studies show that Carnitine indeed is helpful in dealing with a number of heart related diseases.

Boosts overall brain function

A recent study shows that Carnitine aids in the recovery of stroke among animals. This clearly shows that this amino acid targets the brain cells. It contains nutrients that are highly required by the brain to function properly for example vitamins E, B-12 alpha-lipoic acid and folic acid.

Helps in burning body fat

Carnitine is a portent fat burner. It is needed in the transportation of fat into cells which will be used for the production of energy in the body. When the Carnitine levels are increased in the body, the body increases the fat burning process and then boosts energy levels in the body.

Prevents diabetes

This amino acid can prevent diabetes and promotes cardio vascular health. With its antioxidant properties Carnitine eliminates free radicals and also reduces oxidative stress. This is very important in the improvement of your insulin health and also help in fat loss.

Improves male fertility

Studies show that adequate Carnitine levels in the body are necessary for male fertility. According to the study fertile males had adequate levels of this amino acid it was associated with healthier sperm. While the others who were considered infertile had compromised sperm health and lower Carnitine levels.

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Raspberry ketone for weight loss
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Date: June 11, 2012 08:21 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Raspberry ketone for weight loss

Raspberry ketones

Raspberry ketones are natural compounds that are found in raspberry plants and that are able to regulate metabolism in the same manner as synephrine and capsaicin since they are chemically similar. Ketones are also responsible for the pleasant smell of raspberries and they are also used as a flavoring ingredient for processed food. Various studies have shown that these ketones are also extremely potent fat burners and this is the main reason why they are highly marketed as being an effective solution for weight loss.

It was scientifically proven that people who choose to live a healthy lifestyle and who also watch their weight can have a significant benefit from using raspberry ketone supplements. Most people can lose a considerable amount of weight by using these supplements and it works with any type of diet. It also works extremely well and burns fat even more effective when it is combined with a high protein diet that is low on fat. This is basically one of the main reasons why this supplement is so high in demand nowadays.

Weight Loss

Whenever raspberry ketone is used as a supplement the core temperature of the body is significantly raised. Therefore the metabolism rate will also be increased and it will cause the body to burn fat and calories much faster, making this compound very popular and effective when it comes to weight loss. In addition, these ketones will also make the overall fat that the body is absorbing from a regular diet to be reduced. In fact, a study conducted on rats in Japan reveals that this compound is extremely effective in fat loss after it prevented fat from accumulating in their tissues. This is a strong evidence that proves how effective for boosting metabolism and burning fat this supplement really is. Although no study was documented on humans, there are various positive feedbacks from users that prove to be effective and free of any side effects as well.

Due to the raspberry ketone effectiveness, most nutritionists and dietitians are also recommending to eat a few raspberries along with meals. People who went for a healthy diet and also consumed raspberries on a regular basis have experienced positive weight loss results. This fruit is also very delicious and is rich in fiber so it is a good addition to any meal. Raspberry ketones are also known for several other health benefits such as maintain the level of fat and cholesterol in the body. Also, by consuming this compound you can also maintain your blood pressure levels in normal range, therefore these ketones are also good for maintaining the overall health for the cardiovascular system.

So basically all these healthy and beneficial properties make raspberries a very healthy fruit. They also contain anti-oxidants which are most needed for combating the harmful free-radicals present in the body. Since it would take many pounds of actual raspberries in order to get any significant results, supplements based on this compound are the perfect choice in order to get the recommended dosage (usually around 100-300mg).

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How DoesTurmeric Help Improve Your Health?
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Date: March 22, 2012 07:42 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How DoesTurmeric Help Improve Your Health?

Turmeric - Curcumin

This is a perennial herbaceous plant which belongs to the ginger family making it an important plant because of its active ingredient, curcumin and other properties which makes it avery useful plant in terms of health when used. The rhizomes of turmericare gathered annually for preparation of various health products or foods or taken on its own as they are known to have greater concentrations of curcumin and other substances which are essential for good health. When turmeric is taken, it improves one's health in the following ways:

Weight loss; for those people who are overweight and obese, they always face a challenge on how they can get rid of some extra weight as it is associated with negative health implications and on the other hand fats such as belly fat decrease one's self esteem. Turmeric is one of the herbs that if mixed with food will increase the rate of metabolism which will consequently help in fat loss which will ultimately have an effect on the weight. Thereforemanageable weight will always ensure that one is not at risk of developing cardiovascular heart diseases and other lifestyle diseases which will ultimately promote good health.

Cancer and turmeric; cancer is one of the killer diseases which was very common in developed countries but nowadays it is very rampant even in developing countries. By taking turmeric, the active ingredients in it will help in stopping and preventing the development of cancer more especially prostate cancer which affects men. This herb interferes with the abnormal cell division of the cells hence leading to a stop or prevention of cancer progression thus health improvement. It is important to note that turmeric is also very effective in preventing other types of cancers for example breast cancer from spreading to other parts of the body such as the lungs. The effectiveness of turmeric in fighting cancer can be increased by mixing it with cauliflower flower.

Detoxification; turmeric is rich antimicrobial properties, antiseptic properties which make it a very useful plant when it comes to cleansing of the body. The body is usually bombarded with a lot of chemicals and toxins from the environment and what is eaten hence need to cleanse it. This can be achieved by taking turmeric on its own or mixing it with other foods and taking it two to three times a day for a period of about one month. This will go along way in detoxifying the body more especially the liver which will make it more healthy hence work better as it is one of the largest organ in the body.

Fighting inflammation; this is one of the common symptom of very many ailments and by taking turmeric, it will be able to fight inflammation resulting in improved and good health. It has also been associated with the reduction or clearing of symptoms of arthritis (rheumatoid arthritis and osteoarthritis). This will improvemotion of the patient which willfinally have an impact on performance of the patient thus have a positive impact on the health of those with these conditions.

Turmeric can also be used as a natural disinfectant for example when burns and cuts occur at home, it can be applied thus hastening the healing process.

As you can see, turmeric with curcumin has a wide range of uses, you too should have this wonderful herb on hand in case of emergencies.

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What is Forskoline and How Does It Help You Loose Weight?
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Date: February 09, 2012 05:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What is Forskoline and How Does It Help You Loose Weight?

While the Ayurvedic Coleus forskohlii contains numerous ingredients, however, the most integral active ingredient in the herb is known as Forskoline. It is the mint family that this herb belongs to, and Burma,India and Thailand, which are all subtropical areas, are some of the places where this herb grows. Over the years, a lot research has been done on the main ingredient in this herb. In the recent times, this ingredient has become particularly popular for the benefits that have been discovered it offers for weight loss.

What Can Forskoline Be Used For?

In the few clinical and scientific studies that were conducted on Forskoline, this natural component was discovered to be a lipolytic or a fat burning agent. The individuals who were subjected to testing lost quite a significant weight when they were give this ingredient to use as a weight loss aid. Ever since then, several weight loss products have been produced that contain this component as their main ingredient.

What is the Function of Forskoline?

The adenylate cyclase enzyme is activated by this component. Typically, adenylate cyclase are also activated by fat burning hormones, however, their have higher CNS effects. On the other hand, the CNS effects of Forskoline are different so no side effects are caused if it is used for losing weight. Thus, while functioning like most fat loss agents, the levels of the lipolytic hormone are not increased by it.

Apart from acting as a safe weight loss agent, Forskoline also offers various other health benefits too. It, in fact, particular helps with cardiovascular health. As far as cardiovascular health is concerned, not only this but several others of the active ingredients that the Coleus forskohlii have been discovered to be beneficial for the cardiovascular system.

What are the Side Effects of Forskoline?

There are actually no known side effects associated with the use of this component, which has been proven by the several studies conducted on it and the herb it comes from. Nonetheless, if people decide to use Forskoline, they should consult a doctor first. There are chances that people might experience drowsiness if they consume in a really large dose, which is natural considering it is an antihistamine, however, this should be avoided. Taking it before going to bed or taking it along with stimulate is most appropriate.

Today there are numerous Forskoline products available in the market and those who are looking for the best one should pay attention to the amount of this particular ingredient the product contains. Typically, a 2% extract in a 250 mg tablet is adequate enough. Products containing 10 to 20% of this extract can be considered the best. People should start using such a product with two to three doses of 25 to 60 mg in a day, divided accordingly.

These days it is hard to find weight loss products with so many benefits and almost no side effects. The weight loss products containing Forskoline might certainly seem like a miracle for those who want to lose weight and those who decide to use will indeed be able to effectively shed the pounds.

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How Does N-Acetyl L-Carnitine Help Energy Levels?
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Date: August 03, 2011 11:47 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does N-Acetyl L-Carnitine Help Energy Levels?

N-Acetyl L-Carnitine And Cellular Health

N-Acetyl L-Carnitine refers to the ester form of the organic compound carnitine. It has been linked to many different health benefits largely owing to the fact that it is quite ubiquitous at the cellular level. It plays an important role in keeping cells in prime working condition as derivatives of this compound protect cells from oxidative stress as well as contribute to reactions responsible for energy production.

Increases Cellular Energy

The biochemical energy that powers cellular activities comes in the form of adenosine triphosphate. All types of tissues in the human body are capable of manufacturing this chemical compound, the reason why it is often called the molecular unit of currency. The human diet provides the biological precursors of cellular energy, but adenosine triphosphate is obtained from the sugar glucose more often than not.

Cells make use of N-acetyl L-carnitine in the synthesis of adenosine triphosphate. Research has shown that the presence of acetylated carnitine appears to modulate the metabolic processes leading to the manufacture of cellular energy. In recent years, endurance athletes and body builders have relied on supplements that contain this compound to boost their energy levels. Human trials support its safety.

Aids Healthy Metabolism

Glucose is the principal precursor of chemical energy in the form of adenosine triphosphate. Complex carbohydrates are digested to simple sugars such as glucose, which enters the circulation. Insulin is a hormone that induces the uptake of glucose by cells, which convert glucose to usable energy. Studies have observed that N-acetyl L-carnitine improves the activity of insulin and consumption of glucose.

It is a well established fact that carnitine is involved in the breakdown of fats, waxes, and sterols, and their consequent utilization in the production of cellular energy. For this reason, N-acetyl L-carnitine is marketed as a nutritional supplement that promotes fat loss and aids weight loss. Human trials have noted that regular intake upregulates the conversion of fats and other lipids to adenosine triphosphate.

Prevents Oxidative Stress

Lysine and methionine are amino acids that act as immediate precursors of carnitine, which the body synthesizes on a regular basis to support a number of physiological functions. In particular, carnitine plays a major role in supplying cells with a steady supply of chemical energy during intense physical exertion. At the same time, they protect the cells from the harmful effects of reactive oxygen species.

N-acetyl L-carnitine is a very good source of carnitine as it is widely believed to be more bioavailable than L-carnitine. It adds to the number of carnitine in cells, boosts energy levels, and combats free radicals and other reactive oxygen species. Free radicals are natural by-products of energy production, and thus carnitine produces a twofold effect. It promotes cellular longevity and raises chemical energy.

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GABA
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Date: August 26, 2008 04:58 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GABA

GABA is gama amino butyric acid, and is an inhibitory neurotransmitter that is essential for the proper function of your brain and the central nervous system, and has the effect of reducing excessive brain activity and promoting a state of calm.

For many people, the rush of daily life, with its problems, worries and external stimuli, can over-stimulate the brain to the extent that it can all seem too much for them. They feel anxious and overwhelmed, and wish that they could just go into a quiet corner to get away from it all. Most people have felt like that at some time, but the demands of life do not allow them that luxury. They just have to bear it and get on with life.

That is where GABA can come in. It can be used to bring your nervous system back to base, and make you feel more relaxed, calmer and more able to meet these challenges that life often throws at you. When you feel that you just can’t relax or concentrate on what you are doing, GABA can help you. If you look around you and everybody else seems OK, without apparently feeling the stress and irritability that you feel, and then perhaps your problem is due to a GABA deficiency. GABA is the principal inhibitory neurotransmitter in your brain, and a deficiency would certainly give you the symptoms that you are feeling. Let me explain why.

As your brain becomes excited, it can run out of control and needs some form of modification or inhibition to keep it acting as normal. Without this you would become increasingly more restless and irritable, and ultimately have seizures. GABA is not only the main inhibitor in your brain, but also helps in the production of endorphins that provide you with a sense of well being. That sense of calm you feel when endorphins are produced, for example during exercise or sexual intercourse, is commonly referred to as the ‘endorphin effect’.

GABA is at its highest concentration in specific areas of the brain, including the hypothalamus, the hippocampus and the central brain area, and is present in up to 40% of all synapses, the small gaps between neurons across which brain cells can communicate with each other.

It is produced during the Krebs or Citric Acid Cycle that is responsible for cell respiration or the production of energy from carbohydrates. It is synthesized from alpha-keto glutarate, which is produced just before the Succinyl Co-A stage of the Krebs Cycle in the brain. Vitamin B6 in involved in its metabolism, and a Vitamin B6 deficiency can lead to a deficiency in GABA that might result in seizures.

Basically GABA works by inhibiting the firing of neurons in your brain, and thus reducing general brain activity. The GABA receptor allows more chloride ion to enter the brain cell, thus helping to maintain the electrical charge within the cells. Bezodiazepines (e.g. diazepam) work by increasing the effectiveness of GABA in opening the chloride ion cells to allow more chloride ion to enter the neurons, and caffeine does the opposite, and inhibits this property of GABA. Thus diazepam works as a minor tranquilizer and caffeine as a stimulant.

Alcohol has a similar effect to the benzodiazepines, increasing the release of chloride into the neurons, and is the major way in which alcohol affects the brain. In fact, tolerance to drugs and withdrawal symptoms can be explained by the receptors adapting to the drug. They may increase in number, which means that more of the drug is needed to work on them, and they can become hypoactive in the event of the drug being withdrawn, that enhances the symptoms that the drug was intended to treat.

So basically, that is the way that GABA works. In simple terms it increases the flow of chloride electrolyte to the brain, and in so doing affects our mood. This effect is enhanced by prescription drugs such as Valium and Ativan, which are used by those that suffer the effects of a GABA deficiency. However, these drugs have side effects, not the least of which is dependency due to the GABA receptors becoming modified to suit the drug. There is a more natural way to overcome many stress problems and symptoms of mood swings.

Knowing what causes these symptoms, it makes sense to eat foods that stimulate the creation of neurotransmitters to replace those that are deficient. Since GABA is produced in the Krebs Cycle and complex carbohydrates produce glutamine that is an important part of that Cycle, and is also the precursor to GABA, then the consumption of such foods should in theory produce more GABA. In this case the theory works, and you should eat foods rich in complex carbohydrates such as whole grains, brown rice and oats as part of your diet.

Other foods that are high in glutamine or its precursors, glutamic acid and glutamate, include citrus fruits, beef liver, broccoli, halibut and lentils. A useful supplement to take is L-theanine, an amino acid found in green tea, and available in supplement form. L-theanine can calm your nerves while maintaining clarity of thought. In other words it calms you down, but doesn’t make you drowsy and allows you to enjoy your day with anxiety.

Your doctor can determine whether or not you have a neurotransmitter deficiency through a simple urine test, and might also test your saliva for hormone content. A GABA supplement might be indicated, and if so it other beneficial effects on your body other than its effect on your brain cells.

It improves your sleep cycles and promotes vivid dreaming, and can also have a positive effect on your blood pressure. It is also an effective pain killer, and can provide relief from such conditions as back pain and arthritis. Its stimulating effect on the anterior pituitary gland to secrete Human Growth Hormone might also be regarded as a benefit by many. Increasing the level of HGH in your blood can lead to fat loss and improved anabolic activity (increase in muscle tissue). This can be of benefit to older people whose level of HGH secretion has dropped off, and who find it more difficult to lose fat.

GABA is a substance that has many known benefits and no known side effects other than a slight tingling and increase in heart rate when the supplement is first used. It has a definite benefit for people to whom the world seems too hectic and overwhelming.



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Free Form Amino Acids Promote Fat Loss!
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Date: September 07, 2006 01:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Free Form Amino Acids Promote Fat Loss!

To promote fat loss several free form amino acids increase the mobilization and circulation of stored fats in the body. Amino acids also convert fat to energy at the cell’s energy source, the cell mitochondria. With many caloric reduction diets, free form amino acids provide not only fat burning benefits, but also a low calorie, low food volume source of protein with specific benefits to the muscles, liver and immune system critical to optimal health.

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Ergopharm Dietary Supplements
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Date: July 29, 2006 03:01 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Ergopharm Dietary Supplements

About Ergopharm Supplement company.

"Welcome to Ergopharm, a division of Proviant Technologies, the leader in innovative sports supplement technology. Led by world famous chemist Patrick Arnold, Ergopharm employs a full team of chemists, food scientists, and microbiologists to bring you the most effective and highest quality products in the sports supplement marketplace.

Ergopharm started as the industry leader in prohormone products, but has since expanded its line to offer a full spectrum of cutting edge dietary supplements - including fat loss products, protein powders, cellular energizers, and mood enhancers.

As always, Ergopharm stays committed to stringent quality control and its facilities follow strict GMP guidelines. Ergopharm has in-house chemical, physical, and microbiological analytical instrumentation and staff to ensure its products live up to every specification necessary.

If you are not buying Ergopharm products, then you are missing out on the future of sports nutrition."

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7-Keto - Anti-Aging and Antioxidant Protection
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Date: December 18, 2005 09:44 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: 7-Keto - Anti-Aging and Antioxidant Protection

7-Keto

“Anti-Aging and Antioxidant Protection”

The Fountain of Youth Discovered in Wisconsin

It turns out that Ponce de Leon was looking in the wrong place for the fabled Fountain of Youth. It was recently discovered – in Wisconsin! And it turns out that the Fountain of Youth isn’t really a fountain – it’s a biological compound produced in our own bodies. This compound is extremely important for the growth and development of the human body, and, as the body’s production of this substance decreases with age, the signs of aging begin to appear – weight gain, wrinkled skin, loss of muscle, loss of cognitive function, and loss of libido.

This biological Fountain of Youth was discovered by Dr. Henry Lardy and associates at the Institute for Enzyme Research at the University of Wisconsin. It’s called 7-Keto™, a metabolite of a hormone produced by the adrenal glands called DHEA (dehydroepiandrosterone). Research on 7-Keto™ indicates that it may work through a number of pathways to combat the signs of aging. Helping the body maintain a healthy weight as we age greatly improves overall health and longevity and is one of the strongest benefits discovered for 7-Keto™ to date.

Unfortunately, because 7-Keto™ is a metabolite of DHEA, whose levels decline as we age, so to does this wonderful, natural bio-nutrient. Scientists originally looked to DHEA for improved cardiovascular vitality, and strengthened immune and brain function3. Researchers believed that declining DHEA so profoundly impacted our bodies that it could be partly responsible for the effects of aging. They hypothesized that supplementation with DHEA could sustain hormone levels and stave off many of the degenerative changes we collectively call aging. But there was a catch. Because DHEA is converted into sex hormones, people taking supplemental DHEA would sometimes experience the frightening, unwanted side effects associated with hormone supplementation.

In 1989, Dr. Lardy and his colleagues set out to solve the mystery of eliminating DHEA’s side effects by examining all of the constituents that make up DHEA. Ten long years of research unearthed hundreds of DHEA derivatives, which were developed and tested continuously, until one derivative rose above all the others – a metabolite that was incredibly bio-active and far more promising than any other substance they’d tested. That metabolite is 7-Keto™. 7-Keto™ outperformed DHEA and other metabolites in immune modulation, memory enhancement and thermogenesis and, more importantly, without any adverse side effects3.

The most significant benefit of 7-Keto™ supplementation is its ability to support healthy body weight. Obesity is a major contributing factor in a number of serious medical conditions. A recent study assessed the effectiveness of 7-Keto™ on weight loss and body fat loss. Participants were divided into two groups; one group received 100mg of 7-Keto™ twice daily and the other a placebo. Both groups exercised three times per week. At the end of the study, researchers noted a statistically significant reduction in body weight and body fat only in the 7-Keto™ group. Researchers concluded that 7-Keto™ was three times more effective than diet and exercise alone in promoting weight and fat loss1,2,7. Preliminary research also indicates that 7-Keto™ may support healthy immune and nervous systems. One study measured the effects of 7-Keto™ on memory function. Subjects were given a single dose of a substance that inhibits nerve cell communication and causes shortterm memory loss. Afterwards subjects were given a single dose of 7-Keto™. Results showed that 7-Keto completely reversed the memory impairment, suggesting that 7-Keto™ supports memory retention6.

Another study gauged 7-Keto™’s ability to support immune system function. Interleukin 2 (IL2) is a substance produced by T lymphocytes that causes an increase of disease fighting white blood cells. White blood cells were taken from healthy volunteers and introduced into a solution that contained 7-Keto™ for 24 hours. When the cultures were tested for heightened IL2 production. 7-Keto™ was shown to augment IL2 production by a statistically significant 68%4.

NOW® 7-Keto™ is a well-researched and patented form of this amazing product that’s supplied by the Humanetics Corporation. Humanetics 7-Keto™ has been proven safe and well-tolerated in doses up to 200mg5. Research is clear, the rate at which we age can be influenced by the diet and lifestyle choices we make. One very smart choice would clearly be adding NOW 7-Keto™ to your diet.

References

1) 7-Keto™: The Key to Healthy Aging – Scientific Support; Humanetics Corporation, 1999
2) Garbis, Spiro; 7-Keto™ DHEA; internal meta-analysis, 2000
3) Sahelian, Ray, M.D.; DHEA: A Practical Guide; Avery Publishing, 1996
4) Lardy, H. et.al. Dehydroepiandrosterone and 7-Keto™ DHEA Augment Interleukin 2 (IL2) Production by Human Lymphocytes In Vitro, 5th Conference on Retroviruses and Opportunistic Infections, February 1-5, 1998, Chicago, IL
5) Davidson, M.H. et. al. Clinical Safety and Endocrine Effects of 7-Keto™ DHEA; Presented at Experimental Biology 98 (Conference), April 19-22, 1998, San Francisco, CA
6) Shi, J. et. al. The Effect of 7-oxo- DHEA acetate on memory in young and old C57BL/6 mice; Steroids 65 (2000); 124-129
7) Colker, C. et. al. Double-Blind, Placebo-Controlled, Randomized Clinical Trial Evaluating the Effects of Exercise Plus 3-Acetyl- 7-oxo-dehydroepiandrosterone on Body Composition and the Endocrine System in Overweight Adults; Journal of Exercise Physiology online; Vol. 2, No. 4, October, 1999



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REFERENCES
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Date: June 25, 2005 08:13 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: REFERENCES

REFERENCES

1 a. The Surgeon General’s “Nutrition and Health Report.” b. The Centers for Disease Control and Prevention’s “National Health and Examination Survey (NHANES III)” c. The National Academy of Science’s. Diet and Health Report: Health Promotion and Disease Objectives (DHHS Publication No. (PHS) 91-50213, Washington, DC: US Government Printing Office, 1990). e. Dietary Guidelines for Americans. 2 Rolls BJ. Carbohydrates, fats, and satiety. Am J Clin Nutr 1995; 61(4 Suppl):960S-967S. 3 McDowell MA, Briefel RR, Alaimo K, et al. Energy and macronutrient intakes of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1:1988-91. Advance data from vital and health statistics of the Centers for Disease Control and Prevention; No. 255. Hyattsville, Maryland: National Center for Health Statistics; 1994. 4 Center for Science in the Public Interest and McDonald’s Nutrition and You—A guide to Healthy Eating at McDonald’s: McDonald’s Corp,1991. 5 Bray GA. Appetite Control in Adults. In: Fernstrom JD, Miller GD eds. Appetite and Body Weight Regulation. Boca Raton: CRC Press, 1994:1-92. 6 Michnovicz JJ. How to Reduce Your Risk of Breast Cancer. New York: Warner Book Inc. 1994:54. 7 Carcinogens and Anticarcinogens in the Human Diet. National Research Council Report, National Academy of Sciences, 15 Feb. 1996. 8 Van Tallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979:32: 2723-33. 9 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:273. 10 Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16A-hydroxyestrone to estradiol in human breast concer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1988:85;7831-5. 11 Colditz GA. Epidemiology of breast cancer. Findings from the nurses’ health study. Cancer1993;714:1480-9. 12 Hennen WJ. Breast Cancer Risk Reduction. The effects of supplementation with dietary indoles. Unpublished report 1992. 13 Deslypere BJ. Obesity and cancer. Metabolism 1995;44(93):24-7. 14 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:281. 15 Whittemore AS, Kolonel LN, John M. Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst 1995;87(9):629-31. 16 Key T. Risk factors for prostate cancer. Cancer Survivor 1995;23:63- 77. 17 Kondo Y, Homma Y, Aso Y, Kakizoe T. Promotional effects of twogeneration exposure to a high-fat diet on prostate carcinogenisis in ACI/Seg mice. Cancer Res 1994;54(23):6129-32. 18 Wang Y, Corr JG, Taler HT, Tao Y, Fair WR, Heston WD. Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet. J Natl Cancer Inst. 1995;87(19):1456-62. 19 Nixon DW. Cancer prevention clinical trials. In-Vivo 1994;8(5):713-6. 20 Key T. Micronutrients and cancer aetiology: the epidmiological evidence. Proceed Nutr Soc 1994;53(3):605-14. 21 Gorbach SL, Goldin BR. The intestinal microflora and the colon cancer connection. Reviews of Infectious Diseases 1990;12(Suppl 2):S252-61. 22 Shrapnel WS, Calvert GD, Nestel PJ, Truswell AS. Diet and coronary heart disease. The National Heart Foundation of Australia. Med J Australia. 1995;156(Suppl):S9-S16. 23 Ellis JL, Campos-Outcalt D. Cardiovascular disease risk factors in native Americans: a literature review. Am. J. Preventive Med 1994;10(5):295-307. 24 DiBianco R. The changing syndrome of heart failure: an annotated review as we approach the 21st century. J. Hypertension 1994; 12(4 Suppl):S73- S87. 25 Van Itallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979;32(suppl):2723-33. 26 Kestin M, Moss R, Clifton PM, Nestel PJ. Comparative effects of three cereal brans on plasma lipids, blood pressure and glucose metabolism in mildly hyper-cholesterolemic men. Am J Clin Nutr 1990;52(4):661-6. 27 Story JA. Dietary fiber and lipid metabolism. In: Spiller GA, Kay RM. eds. Medical Aspects of Dietary Fiber. Penun Medical; New York, 1980, p.138. 28 Stein PP, Black HR. The role of diet in the genesis and treatment of hypertension. Med. Clin. North America. 1993;77(4):831-47. 29 Olin JW. Antihypertensive treatment in patients with peripheral vascular disease. Cleve. Clin. J. Medicine. 1994;61(5):337-44. 30 Tinker LF. Diabetes Mellitus—a priority health care issue for women. J. Am. Dietetic Association. 1994;94(9):976-85. 31 Gaspard UJ, Gottal JM, van den Brule FA. Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas. 1995;21(3):71-8. 32 Coordt MC, Ruhe RC, McDonald RB. Aging and insulin secretion. Proc. Soc. Exp. Biology and Medicine. 1995;209(3):213-22. 33 Felber JP. From Obesity to Diabetes. Pathophysiological Considerations. Int. Journal of Obesity 1992;16:937-952. 34 Gillum RF. The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes, and cardiovascular risk factors in men and women age 18-79. J Chronic Diseases 1987;40:421-8. 35 Haffner SM, Stern MP, Hazuda HP, et al. Role of obesity and fat distribution in non-insulin-dependent diabetes mellits in Mexican Americans and non- Hispanic whites. Diabetes Care 1986;9:153-61. 36 Bonadonna RC, deFronzo RA. Glucose metabolism in obesity and type 2 diabetes. Diabetes and Metabolism. 1991;17(1 Pt. 2):12-35. 37 Shoemaker JK, Bonen A. Vascular actions of insulin in health and disease. Canadian J. of Applied Physiology. 1995;20(2):127-54. 38 Resnick LM. Ionic Basis of Hypertension, Insulin Resistaince, Vascular Disease, and Related Disorders. The Mechanism of ‘Syndrome X’. Am. J. Hypertension. 1993;6(suppl):123S-134S. 39 Trautwein EA. Dietetic influences on the formation and prevention of cholesterol gallstones. Z. Ernahrugswiss. 1994;33(1):2-15. 40 Cicuttini FM, Spector TD. Osteoarthritis in the aged. Epidemiological issues and optimal management. Drugs and Aging. 1995;6(5):409-20. 41 Melnyk MG, Wienstein E. Preventing obesity in black women by targeting adolescents: a literature review. J Am. Diet. Association. 1994;94(4):536-40. 42 Robinson BE, Gjerdingen Dk, Houge DR. Obesity: a move from traditional to more patient-oriented management. J. Am. Board of Family Practice. 1995;8(2):99-108. 43 Dulloo AG, Miller DS. Reversal of Obesity in the Genetically Obese fa/fa Zucker Rat with an Ehpedrine/Methylxanthines Thermogenic Mixture. J. Nutrition. 1987;117:383-9. 44 Dulloo AG, Miller DS. The thermogenic properties of ephedrin/methylxanthine mixtures: animal studies. Am J Clinical Nutr. 1986;43:388-394. 45 Richelsen B. Health risks of obesity. Significance of the regional distri-bution of adipose tissue. Ugeskr. Laeger. 1991;153(13):908-13. 46 Lissner L, Heitmann BL. Dietary fat and obesity: Evidence from epidemiology. European J. Clinical Nutrition. 1995;49(2):79-90. 47 Lissner L, Heitmann BL. The dietary fat: Carbohydrate ratio in relation to body weight, Current Opinion in Lipidology. 1995;6(1):8-13. 48 Ravussin E. Energy metabolism in obesity. Studies in the Pima Indians. Diabetes Care. 1993;16(1):232-8. 49 O’Dea K. Westernisation, insulin resistance and diabetes in Australian aborigines. Med J. Australia. 1991;155(4):258-64. 50 Bailey C. Fit or Fat . Houghton Mifflen, Boston, 1991. 51 McCarty MF. Optimizing Exercise for Fat Loss. Unpublished report. 52 Weinsier RL, Schutz Y, Bracco D. Reexamination of the relationship of resting metabolic rate and fat-free mass and the the metabolically active components of fat-free mass in humans. Am. J. Clinical Nutrition. 1992;55(4):790-4. 53 Evans WJ. Exercise, nutrition and aging. J. Nutrition. 1992;122(3 suppl):796-801. 54 Schlicker SA, Borra ST, Regan C. The weight and fitness status of United States children. Nutrition Reviews. 1994;52(1):11-7. 55 Raben A, Jensen ND, Marckmann P, Sandstrom B and Astrup A. Spontaeous weight loss during 11 weeks’ ad libitum intake of a low fat/high fiber diet in young, normal weight subjects. Stockholm Press. 1995;916-23. 56 Blundell JE, Cotton JR, Delargy H, Green S, Greenough A, King NA, Lawton, CL. The fat paradox: fat-induced satiety signals versus high fat overconsumption. Short Communication 1995:832-835. 57 Reinhold RB. Late results of gastric bypass surgery for morbid obesity. J Am Coll Nutr 1994;13(4):307-8. 58 McCredie M, Coates M Grulich A. Cancer incidence in migrants to New South Wales (Australia) from the Middle East, 1972-1991. Cancer Causes Control 1994:5(5):414-21. 59 Schiff ER, Dietschy JM. Steatorrhea Associated with Disordered Bile Acid Metabolism. Am. J. Digestive Diseases. 1969;14(6) 60 Nauss JL , Thompson JL and Nagyvary J. The binding of micellar lipids to Chitosan. Lipids. 1983;18(10):714-19. 61 Braconnot H, Sue la natrue ces champignons. Ann Chim Phys 1811;79:265. 62 Odier A. Memoire sur la composition chemique des parties cornees des insectes. Mem Soc Hist Nat Paris 1823;1:29. 63 Johnson EL, Peniston QP. Utilization of shellfish waste for chitin and Chitosan production. Chp 19 In: Chemistry and Biochemistry of Marine Food Products. Martin RE, Flick GJ, Hebard CE and Ward DR (eds.) 1982. p.415-. AVI Publishing Co., Westport, CT. 64 Shahram H. Seafood waste: the potential for industrial use. Kem Kemi 1992;19(3),256-8. 65 Rouget C. Des substances amylacees dans le tissue des animux, specialement les Articules (Chitine). Compt Rend 1859;48:792. Commission on Natural Health Products. 1995 67 Peniston QP and Johnson EL. Method for Treating an Aqueous Medium with Chitosan and Derivatives of Chitin to Remove an Impurity. US Patent 3,533,940. Oct. 30:1970. 68 Poly-D-Glucosamine (Chitosan); Exemption from the Requirement of a Tolerance. Federal Register. 1995;60(75):19523-4. Rules and Regulations. Environmental Protection Agency 40 CFR Part 180. April, 19, 1995. 69 Arul J. “Use of Chitosan films to retard post-harvest spoilage of fruits and vegetables,” Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 70 Karlsen J, Skaugrud O. “Excipient properties of Chitosan,” Manufacturing Chemist. 1991;62:18-9. 71 Winterowd JG, Sandford PA. Chitin and Chitosan. In: Food Polysaccharides and their Applications. Ed: Stephen AM. Marcel Dekker 1995. 72 Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 73 Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 74 Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 75 Zikakis, JP. Chitin, Chitosan and Related Enzymes. Academic Press, Inc. 1984. 76 Abelin J and Lassus A. Fat binder as a weight reducer in patients with moderate obesity. ARS Medicina, Helsinki, Aug- October, 1994. 77 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Increasing effect of a Chitosan and ascorbic acid mixture on fecal dietary fat excretion. Biosci Biotech Biochem 1994;58(9):1617-20. 78 Maezaki Y, Tsuji K, Nakagawa Y, et al. Hypocholesterolemic effect of Chitosan in adult males. Biosci Biotchnol Biochem1993;57(9):1439-44. 79 Kobayashi T, Otsuka S, Yugari Y. Effect of Chitosan on serum and liver cholesterol levels in cholesterol-fed rats. Nutritional Rep. Int., 1979;19(3):327-34. 80 Sugano M, Fujikawa T, Hiratsuji Y, Hasegawa Y. Hypocholesterolemic effects of Chitosan in cholesterol-fed rats. Nutr Rep. Int. 1978;18(5):531-7. 81 Vahouny G, Satchanandam S, Cassidy M, Lightfoot F, Furda I. Comparative effects of Chitosan and cholestryramine on lymphatic absorption of lipids in the rat. Am J Clin Nutr, 1983;38(2):278-84 82 Suzuki S, Suzuki M, Katayama H. Chitin and Chitosan oligomers as hypolipemics and formulations containing them. Jpn. Kokai Tokkyo Koho JP 63 41,422 [88,422] 22 Feb1988. 83 Ikeda I, Tomari Y, Sugano M. Interrelated effects of dietary fiber on lymphatic cholesterol and triglyceride absorption in rats. J Nutr 1989;119(10):1383- 7. 84 LeHoux JG and Grondin F. Some effects of Chitosan on liver function in the rat. Endocrinology. 1993;132(3):1078-84. 85 Fradet G, Brister S, Mulder D, Lough J, Averbach BL. “Evaluation of Chitosan as a New Hemostatic Agent: In Vitro and In Vivo Experiments In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 86 Malette W, Quigley H, Gaines R, Johnson N, Rainer WG. Chitosan A New Hemostatic. Annals of Thorasic Surgery. 1983;36:55. 87 Malette W, Quigley H, Adickes ED. Chitosan effect in Vascular Surgery, Tissue Culture and Tissue Regeneration. In R Muzzarelli, C Jeuniaux, GW Gooday, Eds: Chitin in Nature and Technology. Plenum Press, New York. 1986. 88 Okamoto Y, Tomita T, Minami S, et al. Effects of Chitosan on experimental abscess with Staphylococcus aureus in dogs. J. Vet. Med., 1995;57(4):765-7. 89 Klokkevold PR, Lew DS, Ellis DG, Bertolami CN. Effect of Chitosan on lingual hemostasis in rabbits. Journal of Oral-Maxillofac-Surg, 1991;Aug. 49(8):858-63. 89 Surgery, Tissue Culture and Tissue Regeneration. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 90 Hiroshi S, Makoto K, Shoji A, Yoshikazu S. Antibacterial fiber blended with Chitosan. Sixth International Conference on Chitin and Chitosan. Sea Fisheries Institute, Gdynia, Poland. August 1994;16-19. 91 Shimai Y, Tsukuda K, Seino H. Antiacne preparations containing chitin, Chitosan or their partial degradation products. Jpn. Kikai Tokkyo Koho JP 04,288,017 [92,288,017] 13 Oct 1992. 92 Suzuki K, Okawa Y, Suzuki S, Suzuki M. Candidacidal effect of peritoneal exudate cells in mice administered with chitin or Chitosan: the role of serine protease in the mechanism of oxygen-independent candidacidal effect. Microbiol Immunol. 1987;31(4):375-9. 93 Sawada G, Akaha Y, Naito H, Fujita M. Synergistic food preservatives containing organic acids, Chitosan and citrus seed extracts. Jpn, Kokai Kokkyo Koho JP 04 27,373 [92 27,373] 30 Jan 1992. 94 Min H-K, Hatai K, Bai S. Some inhibitory effects of Chitosan on fishpathogenic oomycete, Saprolegnia parasitic. Gyobyo Kenkyu, 1994;29(2):73-4. 95 Nelson JL, Alexander JW, Gianotti L, Chalk CL, Pyles T. The influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutr 1994;10(1):32-6. 96 Ochiai Y, Kanazawa Y. Chitosan as virucide. Jpn Kokai Tokkyo Koho 79 41,326. 97 Hillyard IW, Doczi J, Kiernan. Antacid and antiulcer properties of the polysaccharide Chitosan in the rat. Proc Soc Expl Biol Med 1964; 115:1108-1112. 98 Shibasaki K, Sano H, MatsukuboT, Takaesu Y. pH response of human dental plaque to chewing gum supplemented with low molecular Chitosan. Bull- Tokyo-Dent-Coll, 1994:35(2): 61-6. 99 Kato H, Okuda H. Chitosan as antihypertensive. Jpn. Kikoi Tokyo Koho JP 06 56,674 [94 56,674] 100 Kato H, Taguchi T. Mechanism of the rise in blood pressure by sodium chloride and decrease effect of Chitosan on blood pressure. Baiosaiensu to Indasutori 1993;51(12):987-8. 101 Muzzarelli R, Biagini G, Pugnaoni A, Filippini O, Baldassarre V, Castaldini C, and Rizzoli C. Reconstruction of Periodontal Tissue with Chitosan. Biomaterials. 1989;10:598-603. 102 Sapelli P, Baldassarre V, Muzzarelli R, Emanuelli M. Chitosan in Dentistry. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 103 Borah G, Scott G, Wortham K. Bone induction by Chitosan in endochrondral bones of the extremities. In Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 104 Ito F. Role of Chitosan as a supplementary food for osteoporosis. Gekkan Fudo Kemikaru, 1995;11(2):39-44. 105 Nakamura S, Yoshioka T, hamada S, Kimura I. Chitosan for enhancement of bioavailability of calcium. Jpn. Kokai Tokkyo Koho JP 07 194,316 [95 194,316] 01 Aug 1995. 106 Maekawa A, Wada M. Food Containing chitin or its derivatives for reduction of blood and urine uric acid. Jpn. Kokai Tokkyo Koho JP 03 280,852 [91 280,852], 11 Dec 1991. 107 Weisberg M, Gubner R. Compositions for oral administration comprising Chitosan and a pharmaceutically acceptable carrier. Antacid preparations for alleviating gastric hyperacidity. U.S. patent 3257275 108 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Mechanism for the inhibition of fat digestion by Chitosan and for the synergistic effect of ascorbate. Biosci Biotech Biochem1995;59(5):786-90. 109 McCausland CW. Fat Binding Properties of Chitosan as Compared to Other Dietary Fibers. Private communication. 24 Jan1995. 110 Deuchi K, Kanauchi O, Imasato Y, Kobayashi E. Biosci Biotech Biochem. 1994:58,1613-6. 111 Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 1989;119(8):1100-6. 112 Weil A, M.D. Natural Health Natural Medicine: Boston: Houghton Mifflin, 1990:182. 113 Chen Y-H, Riby Y, Srivastava P, Bartholomew J, Denison M, Bjeldanes L. Regualtion of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells. J Biol Chem 1995;270(38):22548-55. 114 Intestinal Absorption of metal ions and chelates. Ashmead HD, Graff DJ, Ashmead HH. Charles C Thomas, Springfield, IL 1985. 115 Nutrient Interactions. Bodwell CE, Erdman JW Jr. Marcel Dekker New York 1988. 116 Heleniak EP, Aston B. Prostaglandins, Brown Fat and Weight Loss. Medical Hypotheses 1989;28:13-33. 117 Connor WE, DeFrancesco CA, Connor SL. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann NY Acad Sci 1993;683:16-34. 118 Conte AA. A non-prescription alternative in weight reduction therapy. The Bariatrician Summer 1993:17-19. 119 McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Unpublished manuscript. 120 Bray GA. Weight homeostasis. Annual Rev Med 1991;42:205-216. 121 Dulloo AG, Miller DS. The thermogenic properties of Ephedrin/Methylxanthine mixtures: Human studies. Intl J Obesity 986;10:467-481. 122 Arai K, Kinumaki T, Fujita, T. Bulletin Tokai Regional Fisheries Res Lab. 1968;No. 56. 123 Bough WA. Private communication. 124 Freidrich EJ, Gehan, EA, Rall DP, Schmidt LH, Skipper HE. Cancer Chemotherapy Reports 1966;50(4):219-244. 125 A Drovanti, AA Bignamini, AL Rovati. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebo-controlled double-blind investigation. Clinical Therapeutics 1980;3(4):260-272. 126 K Deuchi, O Kanauchi, M Shizukuishi, E Kobayashi. Continuous and massive intake of Chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet. Biosci. Biotech. Biochemistry. 1995;59(7):1211-6. 127 . BesChitin W in Chitin Wound Healing (video), Unitika Corporation, April 1992.

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MECHANISMS OF CHITOSAN FAT- BINDING
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Date: June 25, 2005 08:02 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: MECHANISMS OF CHITOSAN FAT- BINDING

MECHANISMS OF CHITOSAN FAT- BINDING

The exact way(s) that Chitosan prevents fat absorbtion is not fully understood but a number of experimental observations support two basic mechanisms. The first mechanism involves the attraction of opposite charges which can be compared to the attraction of opposite magnetic poles. The second entrapment mechanism can be compared to the effect of a net. In the first mechanism the positive charges on chitosan attract the negatively charged fatty acids and bile acids binding them to the indigestible chitosan fiber. This mechanism can explain why chitosan reduces LDL cholesterol levels.

Our bodies make bile acids in the liver using the cholesterol from LDL. When chitosan binds bile acids it increases the rate of LDL loss thus improving the LDL to HDL ratio. If enough bile acids are bound, the fats are not solublized, which prevents their digestion and absorption. The second mechanism (figure 2) describes a netting effect of chitosan fiber.

In this model the Chitosan wraps around fat droplets and prevents their being attacked and digested by lipid enzymes. Fats unprotected by Chitosan are digested and absorbed. The “netting” mechanism has been seen to operate in vivo. 108

Substances that Enhance the Action of Chitosan

Fibers can be likened to a tangled-up chain. Fibers must “unravel” in order for them to be of maximum benefit to us. “Unraveling” is especially critical for chitosan because each link has a hook on which to attach lipids. Chitosan can absorb an average of 4 to 5 times its weight in lipids. Reports of numbers above and below this range have also been reported and may well reflect the rate or extent of unraveling that had taken place. Fiber formulations can be prepared that unravel rapidly and swell quickly. These highly effective formulations are called superabsorbants. When certain substances are added to chitosan, its remarkable fat-binding ability can be significantly enhanced.

Ascorbic Acid

D-Ascorbic acid (erythorbic acid) and L-ascorbic acid are C-vitamins which enhance chitosan’s ability to bind lipids. Combining chitosan with ascorbic acid results in even less fat absorption and greater fecal fat losses.77,108 In one study the addition of ascorbic acid to a chitosan enriched diet increased fecal fat losses by 87 percent and decreased fat absorption by over 50 percent.77

Cholesterol oxides cause lesions in artery walls which predispose blood vessels to collect plaque. These dietary cholesterol oxides profoundly influence the initiation of heart disease.Free radicals can also contribute to the formation of cholesterol oxides which are even more likely to damage the heart. Cholesterol oxides have been found in deep-fried foods, powdered eggs, processed meats and in human blood itself. Consequently, taking antioxidants like ascorbic acid is vital to protect against the cellular damage this type of free radical causes.112

Citric Acid

In feeding experiments with animals, adding citric acid to a chitosan enriched diet resulted in a decreased feed consumption.77 The most likely explanation for this effect is that the citric acid may be enhancing the swelling action of chitosan leading to a sense of fullness, producing satiety and appetite suppression.

Indoles

Indoles are remarkable phytochemicals which have the ability to selectively activate certain Mixed Function Oxidases (MFOs).113 These MFO’s help balance estrogen metabolism and prepare dietary toxins for elimination before they are absorbed. The presence of fiber in the intestines provides a bulk agent to carry the metabolized toxins out of the body. Chelat ed Minerals The very best approach to weight loss is to nutritionally augment food choices with nutrient supplementation. Certain biochemical compounds are essential to promoting vigor during the process of thermogenesis. Chelated minerals act to bolster, support and protect the organ systems of the body.114,115

For example, when fat is burned, heat and energy are released. If a lack of certain minerals exists, energy levels will drop. Minerals help to transport needed nutrients to depleted areas of the body, thereby stemming off the fatigue we so often experience after eating a fatty meal. Even more importantly, free radicals are released whenever fat is consumed and burned and the presence of chelated minerals helps to expedite the removal of these metabolites and facilitate the availability of fuel for energy.

Essential Fatty Acids

Prostaglandins control and balance many body functions. The dietary building blocks for making prostaglandins are the essential fatty acids (EFAs). The role of prostaglandins in weight loss has been extensively discussed in a recent review.116 EFAs exert profound lipid-lowering effects.They reduce the synthesis of triglycerides and very low density lipoproteins (bad cholesterol) in the liver. EFA supplementation coupled with a low-cholesterol, low-saturated fat in diet produces a complementary effect in lowering serum lipid levels.117 Garcinia Cambogia ( Hydroxy Cit ric Acid) Garcinia Cambogia contains hydroxycitric acid (HCA). This form of citric acid inhibits the liver’s ability to make fats out of carbohydrates.118

Carbohydrates are converted to glycogen stores, not fat stores, giving the body a better energy reserve and an increase in stamina.119 Ephedra And Thermogenisis Thermogenesis means “creating heat.” This is one of the ways our bodies have of burning off excess calories and maintaining a constant weight.120 This is an area of weight management research that is being intensely studied. When we repeatedly yo-yo diet or abuse ourselves by eating too much, our thermogenic ability may be reduced. Numerous animal and human studies have confirmed the benefits of ephedra and methylxanthines in inducing weight loss and restoring thermogenic responsiveness.43,44,121

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Building the Burn
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Date: June 14, 2005 12:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Building the Burn

Building the Burn by Marjorie Flakowitz Energy Times, June 11, 2004

When was the last time you exercised? During the past decade, the number of obese Americans has jumped by 50%. A big factor in this increase: lack of physical activity.

Today, technological society seems to make everyday life effortless: car windows retreat at the push of a button, remote controls keep couch potatoes from budging off the cushions and video games have replaced non-cyber ball playing. Americans don't move around and burn off the calories they eat. Instead, our sedentary ways are causing big stomach bulges and a big bulge in health problems linked to being overweight.

Want to lose those pounds? Consuming the right nutrients and pounding the pavement are a great start.

Number of Large Americans Grows Larger

Fifty-five out of every 100 Americans are now overweight. And the numbers continue to surge. To take yourself out of these alarming statistics, plan a consistent exercise program. If the thought of sweating during strenuous workouts at the gym scares you, relax. You don't have to do that much. According to a long list of research, a few half-hour walks a week can put you on the road to weight loss.

For instance, researchers at Duke found that walking a total of only 12 miles a week can help you control your weight even if you're not dieting (Archives of Internal Medicine 1/12/04). Of course dieting and taking the right supplements will help you lose weight a little faster, but walking burns off the pounds.

In the study at Duke, scientists gathered about 180 overweight, sedentary people and assigned them to one of four groups. The first group had to jog about 20 miles a week. The second group jogged 12 miles a week. The third group walked 12 miles, and the last group didn't do a thing.

" We found that the two low-exercise groups lost both weight and fat, while those in the more intensive group lost more of each in a 'dose-response' manner," says Cris Slentz, PhD, one of the researchers. " Simply put, the more you exercise, the more you benefit. Just as importantly, the control group of participants who performed no exercise gained weight over the period of the trial."

Everybody who was exercising lost weight; their stomachs and hips shrank. The folks who did nothing didn't just stay at the same weight; their weight went up.

Dr. Slentz adds, "From the perspective of prevention, it appears that the 30 minutes per day will keep most people from gaining the additional weight associated with inactivity. Given the increase in obesity in the US, it would seem likely that many in our society may have fallen below this minimal level of physical activity required to maintain body weight."

Enzyme Help

Of course, limiting the carbohydrates you consume and eating more protein at the same time as you exercise can help you lose weight more effectively. To help your body utilize protein more fully to fuel your exercise, many experts recommend taking enzyme supplements.

One of the most valuable enzyme combinations in this process is Aminogen(r), an all-natural, patented plant enzyme that assists the digestive tract in liberating the amino acids that are the building blocks of dietary protein. By helping separate these amino acids, absorption is boosted through the walls of the small intestines and your metabolism is better able to take up proteins and use them.

Add Chromium to Exercise

The mineral chromium is another supplement found helpful in aiding weight loss. An eight-week study at the University of Texas, Austin, compared weight loss among obese women who exercised and took chromium with the number of pounds that were lost by women performing the same amount of exercise without taking supplements (Medicine & Science in Sports & Exercise 1997; 29:992-8).

The result: women taking chromium lost a significantly greater amount. How does chromium work? A study at the University of Vermont found that chromium may help muscles take blood sugar (glucose) out of the blood more effectively by improving what's called insulin sensitivity (18th International Diabetes Federation Congress, Paris, 8/03).

Sensitizing Insulin

Insulin is released by the pancreas to help cells take in glucose. By exercising and keeping your weight down, and becoming more insulin sensitive, you potentially reduce your chances of getting diabetes. The cells quickly respond to insulin and blood sugar stabilizes.

On the other hand, when insulin sensitivity drops significantly, the body may suffer what's called insulin resistance, a pre-diabetic condition that complicates and slows the removal of sugar from the blood. The Vermont researchers found that chromium increases the activity of a protein called Akt phosphorylation. This is a natural substance made by the body that makes cells more sensitive to insulin and speeds the movement of blood sugar into cells, where it can be burned for energy. So, in combination with exercise, which also helps the body become more responsive to insulin, chromium may help keep blood sugar under control.

As Sandra Woodruff points out in her book Secrets of Good Carb, Low Carb Living (Avery/Penguin), "[P]hysical activity boosts the body's ability to process carbohydrate and helps reduce insulin resistance....Exercise acts much like an insulin-sensitizing drug to make the body's cells more responsive to insulin, which enables them to remove sugar from the blood more efficiently." The results of exercise and getting sufficient chromium can help support weight loss and healthy blood sugar levels. The Vermont research team found that the exercising chromium takers boosted their insulin sensitivity by almost 9%.

Building a Lean Body

A prime benefit of exercising while you lose weight is that physical activity builds muscle tissue. Muscle tissue, even at rest, burns more calories than fat cells, so having extra muscle means you can eat more and still maintain or lose weight. An aid in this process is Coleus forskohlii root, Benth., a plant that originated in India. Research shows that forskohlii furthers molecular energy processes within cells that support the development of lean body tissue (muscle) and the enzymatic reactions that break down fat.

In a study of about two dozen women who took forskohlii extract, researchers found that taking this supplement was associated with feeling more energetic and less hungry (Experimental Biology meeting, 2002). According to Vladimir Badmaev, PhD, who has studied forskohlii, this herb's help in supporting lean body tissue is crucial to maintaining a healthy weight.

" In highly overweight individuals, fat tissue can constitute up to 70% of body weight. The remaining proportion of body composition corresponds to the lean body mass. Lean body mass is composed of muscle, vital organs, bone, connective and other non-fatty tissues in the body," says Dr. Badmaev.

" The body's metabolic rate is in direct proportion to the amount of lean body mass. Therefore, safely maintaining or increasing lean body mass is an important consideration for any weight-loss strategy."

The Skinny on Calcium

Calcium, long known for its ability to strengthen bones, is now turning out to play a key role in weight maintenance as well. In one study, obese mice who were put on calorie-restricted diets lost body fat when fed extra calcium (Experimental Biology meeting 2000). Both supplemental calcium and low-fat dairy proved effective. What's more, low-fat dairy's ability to burn fat and provoke fat loss have been confirmed in additional research (Obesity Research 4/04; 12:582-90).

Fat cells contain calcium, and scientists believe that the more of this mineral a fat cell contains, the more fat will be burned off. This action is especially important when you cut back on calories, since that often gives your body the idea that it's starving, leading your metabolism to slow and making weight loss extremely difficult.

A Complete Program

To lose weight efficiently, stay in top shape and retain your feelings of energy, you also have to make sure you get enough of the vitamins and minerals necessary for good health.

For those eating a high-protein diet who are limiting their fruits and vegetables, taking a supplement that incorporates nutrients from fruits and vegetables can help restore your feelings of well-being and help maintain your motivation for dieting and losing weight. (Supplements are available that deliver these nutrients without carbohydrates.)

In addition, supplements of what are called ketogenic amino acids-the natural substances that form protein's building blocks-can also help fuel your weight-loss program. These special nutrients can be efficiently used for the body's energy needs, a process that helps you lose weight.

And don't forget to keep moving! Soon you may have the kind of results researchers produced at the University of Pittsburgh when they studied women who exercised 40 minutes, five times a week (Journal of the American Medical Association 9/10/03). Those women lost 25 pounds in six months.

Your results may be just as good or better!



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