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Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?   
Date:
December 07, 2023 12:12 PM
Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! Liver HealthWhen it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol IntoxicationAlcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver diseaseNonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. Beautiful SkinBy activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin LighteningSkin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6592) Glutathione Supplementation Can Boost Your Antioxidant potential and more! 
Date:
October 27, 2022 10:47 AM
Glutathione is a small peptide molecule composed of three amino acids: cysteine, glutamic acid, and glycine. It is produced by every cell of the body, with especially high levels in the liver.* Glutathione is critical for healthy immune system function and is necessary for proper detoxification processes.* It also plays a critical role in maintaining cellular health by directly neutralizing free radicals, as well as by maintaining the activity of vitamins C and E.* This product has glutathione in its reduced, active form for optimal bioavailability.* Glutathione has many benefits, which is why it is often referred to as the "master antioxidant."* It is involved in numerous biochemical reactions in the body, including DNA synthesis and repair, protein synthesis, enzyme activity, and cell signaling.* Glutathione also helps to Detoxify the body by binding to heavy metals and other toxins so that they can be excreted from the body.* In addition, glutathione has been shown to boost energy levels, improve mental clarity and focus, and even promote weight loss.* As you can see, there are many good reasons to make sure you are getting enough glutathione! How to Increase Your Glutathione Levels There are a few things you can do to make sure your glutathione levels stay high. First, eat a diet rich in sulfur-containing foods like garlic, onions, eggs, and cruciferous veggies. You can also supplement with N-acetylcysteine (NAC), which is a precursor to glutathione. Taking methylated B vitamins will also help because they are needed for glutathione production. Finally, make sure you are getting enough vitamin C since it is necessary for glutathione recycling. One of the best ways to increase your glutathione levels is to supplement with Glutathione. This product provides 500 mg of pure reduced L-glutathione per capsule. It is GMO free, vegan friendly, and does not contain any artificial colors or flavors. Glutathione is a pharmaceutical grade product that is manufactured in an FDA-inspected facility in accordance with Good Manufacturing Practices (GMP). With Glutathione, you can be sure you are getting a high quality product that will help you maintain optimal health! As you can see, there are many good reasons to make sure you are getting enough glutathione. If you want to maintain optimal health, consider supplementing with Glutathione. With 500 mg of pure reduced L-glutathione per capsule, it is one of the most potent products on the market. You can be sure you are getting a high quality product that will help you maintain optimal health! Order your bottle today!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6536) Glutathione: The Most Important Molecule You've Never Heard Of
Date:
October 22, 2022 10:17 AM
Glutathione is a small peptide molecule composed of three amino acids: cysteine, glutamic acid, and glycine. It is produced by every cell of the body, with especially high levels in the liver.* Glutathione is critical for healthy immune system function and is necessary for proper detoxification processes.* It also plays a critical role in maintaining cellular health by directly neutralizing free radicals, as well as by maintaining the activity of vitamins C and E.* Milk thistle extract and alpha lipoic acid are included as complementary ingredients. What does that mean for your health? In short, glutathione is one of the most important molecules for your overall health and wellness. Read on to learn more about this incredible molecule and how you can make sure you're getting enough of it. Why You Need Glutathione Your immune system is your first line of defense against illness and disease. Glutathione plays a critical role in immune system function, so making sure you have enough of it is crucial to maintaining your health. Glutathione is also necessary for proper detoxification processes. It helps your body eliminate toxins and other harmful substances. In addition, glutathione plays an important role in cellular health. It directly neutralizes free radicals, which can damage cells and lead to chronic diseases like cancer. Glutathione also helps keep vitamins C and E active, which are both important for cellular health. Milk thistle extract and alpha lipoic acid are included as complementary ingredients to help support glutathione production. Getting Enough Glutathione You can get glutathione from certain foods, such as broccoli, cabbage, spinach, and garlic.* However, the best way to ensure you're getting enough glutathione is to take a supplement. supplements are the most bioavailable form of glutathione, which means they're better absorbed by the body.* Look for a supplement that contains all three amino acids (cysteine, glutamic acid, glycine) in a 2:1:1 ratio. You should also make sure that the supplement you choose includes milk thistle extract and alpha lipoic acid as complementary ingredients. In Summary: Glutathione is a small but mighty molecule that plays a pivotal role in overall health and wellness. If you're not already taking a glutathione supplement, now is the time to start! Look for a supplement that contains all three amino acids in a 2:1:1 ratio, as well as milk thistle extract and alpha lipoic acid. Your body will thank you for it!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6517) Can Glutamine Improve Nitrogen Balance in the Body?
Date:
May 07, 2014 09:08 AM
Can Glutamine Improve Nitrogen Balance in the Body? Essentials of glutamine have been found to be many. Nowadays there are commercially produced glutamine which are taken as strong anti-catabolic supplement.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3113) What Are The Health Benefits Of Coconut Sugar?
Date:
March 16, 2014 04:33 PM
Coconut sugar and its health benefits
Coconut sugar has the lowest glycemic sugar component index and is one of the best sources of vitamins and minerals that are crucial for the normal body functioning and systemic cycle. With the same features of the normal sugar such as texture and granules, this is the best alternative to have around. The best part of this is that coconut sugar contains no artificial additives and has no artificial preservatives and this makes it the best source of healthy sugar with no whitening and bleaching.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3065) How L-Glutamine Increases Memory And Cognitive Functions!
Date:
January 20, 2014 09:26 AM
L-Glutamine
How the medicinal utilization of L-Glutamine enhances your memory Presently you can encounter all the rushes of having the ability to recall again when you use this characteristic elective health supplement for sum figure quality and persistence. This animated amino acid works through protein combination and compound transformations in distinctive parts of the form which invigorate sound responses to happen. Engaging your psyche from the cell level up, L-Glutamine enhances memory and evacuates collections of smelling salts and nitrogen in the blood which at last influences the working of your cerebrum. Smelling salts is available when this fixing is changed over into glutamic acid which obliges certain measures of alkali. When you standardize these levels, the mind fogginess vanishes as your units accept fitting measures of oxygen and supplements for sound working. Health points of interest of utilizing L-Glutamine to improve memory capacity Furthermore, there are other sound motivating forces to utilize this part also. The point when this valuable substance is changed over into its hostile to oxidizing structure, it improves the benefit of the focal apprehensive framework, beginning at the cerebrum. It can likewise secure your nerves from harm because of hormones, chemicals, and extreme electrical indicators. When you utilize L-Glutamine to improve memory capacity, you are likewise diminishing the dangers of experiencing tension, melancholy, and a large portion of its identified indications in view of its stimulant qualities. This elective health supplement impacts the pituitary organ to discharge certain chemicals, indicators, and hormones all around the figure to equalize out physiological capacities. Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2975) A brief description of ultra enzymes by Natures Plus
Date:
December 21, 2012 04:07 PM
In our daily lifestyle we have to consume fast food on a regular basis, simply because it saves time for us and also they are cost-efficient to some extent. Well, you should be acquainted with the fact that these fast foods are the prime reason for severe digestive disorders which may appear by consuming excessive fast foods. This may occur when the digestive enzymes of the human body fails to perform their actions on these junk food items. We Need Enzymes To enhance the efficiency of the enzymes in our body, some digestive supplements may prove to be quite beneficial for us. These supplements aids us in fetching the desired results of having a proper health by eliminating all the digestive problems from our body. Ultra enzymes are clinically tested and the results have confirmed that these dietary supplements have a number of health benefits and can produce effective results when consumed on a daily basis. Processed foods When food is cooked, most of the vital enzymes and essential vitamins are lost in the process and it becomes tough for the human body to digest these foods. Ultra enzymes by Nature Plus is a dietary supplement which can deliver appropriate results by giving support to the digestive system of the human body. It is the best available digestive aid which has the capability to prevent the digestive disorders from reoccurring in the human body. Ultra Enzyme Ingredients: The components and supplementary facts which are used to describe the efficiency of this particular product includes amylase, lipase, glutamic acid HCl, acidophilus, papain, cellulase, protease, pancreatin 4x, pepsin-NF, malt diastase, hemicellulase and ox bile. All the components are mixed in the appropriate proportions and served in a single and cost-effective unit, which will surely tailor all the requirements of the dieters and also for those people who are going through digestive disorders. Thus, it can be concluded that the ultra enzymes by natures plus is the ultimate remedy for digestive disorders and can help the human body by increasing the rate of absorption and break down of nutrients in your intestinal tract.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2768) How Does Passion Flower Help Me Relax ?
Date:
April 07, 2011 01:39 PM
Passion flower refers to a group of flowering plants that belongs to the genus Passiflora, comprising of up to 500 species. The commonly known plant species of Passiflora are climbing vines with a woody stem system although there are a few herbaceous shrubs. They are found across the globe with the exception of arctic and sub-Saharan regions and easily recognizable by their unique flower structure which often contains prominent styles and stamens. Passiflora incarnata, or more commonly known as Maypop in the vernacular, has a long association with folk medicine of American Indians, who use various parts of the plant as a relaxant. Different species of Passiflora are called different names, but the trivial name passion flower pertains to the corona that resembles the crown of thorns worn by Jesus. Moreover, the Christians have ascribed many symbolisms for the intricate parts of the flower. For example, the ovary is believed to represent the Holy Grail. Early European settlers in the Americas discovered the calming effects of teas made from Passiflora species through the Indians, and popularized its use against anxiety soon after in Europe. Produces Tranquilizing Effects Several studies have investigated the effects of passion flower on human health, with a few comparing it to the drug exazepam. Its mechanism of action is still under scrutiny, but scientists are convinced that its sedative effects are very similar to the herbs Valeriana officinalis and Piper methysticum. More often than not, it is used in combination with these two herbs. As a mild relaxant with a slow onset of action, Passiflora incarnata, or Maypop, have been documented to benefit individuals suffering from irritability, insomnia, and agitation. In conjunction with a drug called clonidine, it also appears to relieve muscle tremors. Increases Inhibitory Brain Chemicals It has long been postulated that passion flower works on the principle of raising the levels of inhibitory neurotransmitters, such as gamma-aminobutryric acid, or GABA. Glutamic acid, the biological precursor of gamma-aminobutyric acid, has been linked to neuronal excitotoxicity that leads to many known diseases of the nervous system. By aiding the metabolic pathway responsible for converting glutamate into gamma-aminobutyric acid, passion flower not only increases the amounts of the chief inhibitory brain chemicals in the human brain and the rest of the central nervous system, but also lowers the levels of excitatory neurotransmitters. This results in a drop in neuronal activities and a reduced risk of excitotoxicity, which translated into a more relaxed feeling. Alleviates Physical Fatigue Passion flower is known to counter the harmful effects of stress. In addition to alleviating psychiatric symptoms of anxiety, Passiflora incarnata has also been tied to the treatment of muscle weakness characteristic of fibromyalgia. It is one of the herbal nervines used in combination with other herbal adaptogens in combating physical fatigue due to long hours at work and the consequent sleep deprivation. Fortunately, passion flower is generally considered safe and nontoxic, with dosages equivalent to food proportions in general. Passion flower can be taken with valerian and skull cap to help calm the mind and body when under intense stress. Give it a try and See for yourself!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2267) Fight Free Radical Damage From Toxins With Vitamins And Herbs
Date:
July 28, 2010 11:34 AM
There are many things that destroy the immune system. Each day we are bombarded with them in many forms. The following are some of the most common ones that are encountered. Agene, also known as Nitrogen Trichloride, is used to bleach flour and give it a white appearance. Unfortunately, it can cause epileptic-like fits along with failure of muscle coordination. Excessive use of alcohol also severely impairs the immune system. It increases susceptibility to infection and weakens the central nervous system. Alcohol promotes chronic lung disease, malignancies of the neck and head, intestinal problems, hypoglycemia, diabetes, liver disease, and a whole variety of other problems. B vitamins, folic acid, niacin, vitamin E, magnesium, zinc, and protein are depleted by alcohol. All of these nutrients play a huge role in immune health. Aspartame breaks down in the digestive tract into a toxic material known as methanol. In order to prevent methanol from metabolizing into formaldehyde, a poison, a person needs to take another poison, ethanol. Glutamic acid is a substance that is found in monosodium glutamate, a flavor enhancer. It affects the central nervous system and can trigger depression, gloomy fantasies, and rage for as long as two weeks following the ingestion of monosodium glutamate. High-diet fat intake increases the levels of bile acids in the colon. This breaks down into deoxycholic and lithocholic acids, both of which are cancer-causing elements. This can cause cancer of both the colon and the rectum. A diet that is high in animal protein and fat can cause cancer of the pancreas, breast, gallbladder, ovaries, uterus, prostate, and leukemia. Junk food such as sweets, white flour, and white sugar products, put a double amount of stress on the body. When too much junk food is eaten, the appetite for good, wholesome food is dulled. Caffeine decreases immunity in the body, with fibrocystic breast disease being connected with the consumption of foods that contain caffeine. It is often caused by the chemicals methylxanthine, theophylline, and theobromine, which are found in coffee, black tea, cola drinks, chocolate, and other soft drinks. These elements act on hormones that cause breast tissue to develop fibrocystic lumps. Caffeine takes away the body’s own use of iron and inositol, and is often suspected of causing cancer in the pancreas. Food dyes and flavorings are the culprits in behavioral problems that occur in children and adults, with some of these problems being learning disabilities and hyperactivity. Sodium nitrate is a preservative that is often found in cured meats like hot dogs, bologna, and ham. It has the potential to produce permanent epileptic changes in brain activity and damage the central nervous system. High protein diets can deplete calcium in the body, especially when the source of protein is an animal product. There are concentrated doses of hormones and antibiotics that are found in beef which suppress the immune system and promote tumor growth. Poly-unsaturated fats undergo a process that produces rancidity in oils. This process releases dangerous free radicals, which eventually lead to cancer. Heavy metals like lead and mercury can cause serious damage to the nervous system, with even small amounts being considered toxic. Lastly, the wide use of vaccinations and antibiotics is considered to be one of the main causes of immune system disorders. Our bodies are under constant attack by our toxic environment. Fortunately, with regular vitamin and herb use, one can help the body restore its immune system to proper function so we can live a happier healthier life.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2174) Glutathion, Antioxidants, And The Body
Date:
July 14, 2010 02:41 PM
Glutathione is an important water-phase antioxidant that is an essential component in the glutathione peroxidase system. Glutathione peroxidase enzymes are crucial for detoxifying peroxides including hydrogen peroxide, which is generated within cellular membranes and lipid-dense areas of the cell, especially the mitochondrial membrane. Severe glutathione depletion often leads to cell death, while experimental glutathione depletion has been found to induce cellular apoptosis. A cellular level of glutathione depletion seems to cause extensive damage to the mitochondria. Depletion of mitochondrial glutathione may, in fact, be the ultimate factor that determines a cell’s vulnerability to oxidative(free radical) attack. The mitochondria is the most crucial place for glutathione presence, as the cascade of oxidation-reduction reactions complete the final steps in respiration take place here. Throughout this process, which is called oxidative phophorylation, electrons invariably escape and react with the ambient oxygen in order to generate toxic free radicals. It has been estimated that 2% to 5% of the electrons that enter the mitochondria are converted into reactive oxygen species that generate considerable oxidative stress for the cell. These free radicals cause an immediate threat to other cellular components, such as the DNA, enzymes, structural proteins, and lipids. The cumulative damage that is caused by oxygen and other free radical species is now determined to be the principal contributor to the degenerative disease process and the progressive loss of organ function that is commonly recognized as aging. Because of this, the cell is constantly challenged to destroy these free radicals before they can inflict any lasting damage. Minimizing oxidative attacks may actually be the ultimate challenge of being alive. Because of this, the reducing power of glutathione is of huge important to the cell. Glutathione is important for helping to regenerate other antioxidants that are depleted from their constant work to fight off free radical challenges. Regeneration that is glutathione-induced may be the mechanism that is actually used by the cell in order to conserve lipid-phase antioxidants, vitamin A, vitamin E, and the carotenoids. It has been confirmed by recent investigations that dietary vitamin C can actually protect us against tissue damage that results from glutathione depletion. Additionally, supplementation with glutathione or its precursors can also quickly replenish any vitamin C deficiencies. Because of this, glutathione and ascorbic acid, both of which are pre-eminent cellular antioxidants, are tightly linked, as glutathione can conserve vitamin C and vitamin C can conserve glutathione. When they are both present, these two antioxidants protect the entire spectrum of biomolecules that are found within the cell, as well as facilitate the cell’s best performance. It has been said that the glutathione status of a cell may be the most accurate single indicator of the health of the cell. This means that as glutathione levels go, the health of the cell will go as well. Glutathione is available in capsule or tablet form at your local or internet health food store. Always choose name brands to ensure quality and purity of the glutathione supplement you choose to purchase for consumption.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2171) Hypoglycemia
Date:
July 16, 2009 01:39 PM
It is critical for one to known that an excess amount of sugar can deplete our vitamin and mineral stores. To make things worse, vitamin and mineral deficiencies can predispose us to both hypoglycemia and diabetes. Significant amounts of B vitamins are necessary in order to metabolize and detoxify sugar after it has entered our bodies. The assimilation of nutrients from other foods is inhibited when the body is overloaded with sugar. To state it simply, our bodies were not designed to cope with the amounts of sugar that we routinely consume. Vitamin A helps the body to maintain normal glandular function. Energy transfers in the body depend upon the presence of vitamin A, which helps to assimilate the mineral efficiently when it is used in conjunction with vitamins D and E. Vitamin B-complex is essential in order to help control the highs and lows associated with hypoglycemia. They boost the adrenal glands and work to calm the nerves and promote mental health. Vitamin B1 is necessary for metabolizing carbohydrates and also improves appetite, digestion, assimilation, and elimination. This vitamin works to protect the nervous system and improve nerve function. Vitamin B2 works in conjunction with niacin and thiamine to protect the nerves and boost the immune system. Additionally, this vitamin helps to facilitate proper digestion, which is essential to healthily metabolize carbohydrates. Vitamin B3 plays a vital role in energy production and carbohydrate metabolism. Also, it is involved in the production of several biochemical’s, among them is adrenaline. Niacin boosts the body’s ability to take in sugar from the blood into the cells. Supplementing the diet of diabetics with niacin is also strongly recommended. A lack of vitamin B5 in the body can cause a drop in blood sugar. This B vitamin is involved in the production of natural cortisone from the adrenal glands and can help to protect the body against the averse affects of stress. It is crucial for the maintenance of a healthy endocrine system. Vitamin B6 is vital in helping to maintain hormonal functions and endocrine balance. Vitamin B6 strengthens the adrenal glands and helps to protect the pancreas. It is essential for the metabolism of proteins and for the production of hormones and antibodies. Additionally, vitamin B6 may also help to prevent complications that may occur from diabetes. Vitamin B9, B12, D, E, C, K, PABA, Biotin, Lecithin, Inositol, and Bioflavonoids are also essential for assisting the body against hypoglycemia. There are also minerals, amino acids, and herbs that helps the body fight against hypoglycemia. These minerals include calcium, chromium, iodine, magnesium, manganese, potassium, selenium, and zinc. Amino acids that assist in hypoglycemia are alanine, carnitine, glutamic acid, and phenylalanine and tyrosine. Herbs for hypoglycemia include alfalfa, bilberry, bitter melon, black cohosh, buchu, cedar berries, damiana, dandelion, dulse, fenugreek, garlic and onions, ginseng, gentian, golden seal, gymnema sylvestre, ho-sho-wu, kelp, licorice, mullein, parsley, pterocarpus, red raspberry, saffron, saltbush, sarsaparilla, saw palmetto, suma, and uva ursi. Alfalfa nourishes all the glands, especially the pituitary, while bilberry is valuable for anyone who suffers from glucose impaired diseases. Suma is used by both men and women to restore body function and are also good for poor circulation, heart disease, and arthritis. Uva Ursi helps to regulate glucose transfer to the nerve fivers which feed the brain. Many of the above listed vitamins, minerals, and herbs are available in combinations directly formulated to help with high blood sugar. Look for these great vitamins and more at your local or internet health food store. Remember to always choose name brands to ensure you purchase a high quality and pure product.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins, minerals and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2033) Protect The Liver with Glutathione And Cysteine
Date:
April 23, 2009 01:54 PM
The tripeptide L-glutathione is synthesized in the body from L. glutamic acid, L-cysteine and glycine, a reaction that can occur in any cell of the body although it is essential that it also occurs in the liver. Should glutathione concentrations drop, they can be increased by supplementing with cysteine or any other of the three amino acids that are used in the biosynthesis of this important if substance The tripeptide exists in two forms: the reduced form (GSH) which contains a sulfhydryl (SH) functional group attached to the cysteinyl part of the molecule, and the oxidized form glutathione disulfide (GSSG). As electrons are lost from the reduced form, two molecules combine to create a dimer formed by a disulfide bridge, the process which can be reversed through reduction of the GSSG. Such electrons are lost during its reaction with free radicals, in which the free radicals are neutralized by the donation of an electron from the oxidized version of glutathione. The definition of a free radical is a molecule that is lacking one electron from an electronic pair. Its prime purpose is then to steal an electron from the nearest molecule to it. In doing so, it can not only destroy that molecule, but also destroy body cells and lead, not only to premature aging, but also to some potentially fatal conditions. It is an unusual peptide in that it involves a link between the cysteine amino grouping and the carboxyl functional group of the glutamic acid. It is a powerful antioxidant, acting as an effective free radical scavenger and protecting the body cells from the effects of free radical oxidation. However, it is on its detoxification effect in the liver that we shall focus here prior to discussing some other uses to which the body puts glutathione in its two manifestations. Much of the detoxification is connected with the thiol group in the molecule. Take mercury for example. The thiol grouping forms a strong Hg-sulfydryl chemical bond within the liver, in the form of a glutathione-mercury chelate. In this form mercury is unable to exert any toxic effect on the body and can be excreted in the normal manner. The same reactive pathway is followed by other heavy metals that can bond to thiol groupings. In this way L-glutathione can protect the liver from the effects of a number of toxic heavy metals such as cadmium and chromium. This is an important property of the amino acid, particularly in industrial and urban environments where the population is more prone to exposure to heavy metals than their rural counterparts. However, the end result on the glutathione is that it is removed from the body, and, particularly with city dwellers, a supplement may be required to maintain a healthy concentration of this amino acid in the body and in particular in the liver. Therefore, although L-glutathione is not considered an essential amino acid, in that it is biosynthesized within the body, a supplement is sometimes required, particularly by those who live in large cities. It is important to consider the form in which the glutathione supplement is administered. This is because of the presence of gamma-glutamyltranspeptidase within the digestive system. This enzyme appears to destroy L-glutathione before it can be absorbed in the intestine so normal oral forms of supplementation are likely to be ineffective. Possible forms of effective administration include buccal (between the cheek and teeth) and hypodermically. An alternative means of supplementation is to take substances such as selenium, methionine, alpha-lipoic acid, vitamin C and glutamine that stimulate the biosynthesis of glutathione. Also, since the substance utilizes the raw materials of L-cysteine, glutamic acid and glycine in its intracellular production, supplementation with these amino acids should also help to produce L-glutathione. That said, let's return to its antioxidant properties and its effect on the liver that contains the largest stocks of glutathione in the body. It is generally regarded as the most important antioxidant in the body. It protects cellular cytoplasm from oxidation by reducing disulfide groups and maintaining a highly reducing environment within the cytoplasm. It reacts with hydrogen peroxide and other oxidative agents, and is converted to the oxidized form GSSG. It is then reduced back to GSH through the combination of the reducing agent and an enzyme. The reducing agent is nicotinamide adenine dinucleotide phosphate (NADPH), the enzyme being glutathione reductase. The implications that this strong reducing effect has on the liver are significant. Reduced GSH L-glutathione levels have been found in patients suffering from HIV, hepatitis C and other liver diseases. Supplementation with GSH has been found to restore normal levels of glutathione to the liver, and it has been demonstrated that the treatment has improved such conditions significantly. Atherosclerosis is a condition of the arteries caused by the deposition of plaques formed from oxidized low-density lipoproteins, otherwise known as bad cholesterol. The strong antioxidant effect of GSH prevents this from LDLs from being oxidized and deposited on the arterial wall. There are other results of glutathione supplementation that indicate the effectiveness of antioxidants in the treatment of serious liver conditions, and there are no doubts that combating the effects of free radicals and oxidizing agents within the liver has a positive effect on many potentially serious liver diseases. Many of these are exacerbated by the generation of free radicals by relatively modern pollution sources such as pesticides, petrol and diesel emissions, tobacco fumes and various other chemical emissions. A strong antioxidant such as L-glutathione cannot be anything other than an effective means of reducing the biological effect of these oxidants. It protects not only the liver but also the lungs and cardiovascular system. For all these reasons a supplement consisting of L-glutathione or its constituent parts, glutamic acid, cysteine and glycine, provide significant protection against the stresses and strains of modern living. Increased pollution levels and heightened oxidative stress levels within the body are playing havoc with our body defenses, and GSH is an important one of them that can easily be enhanced by supplementation. There are no known reactions to L-glutathione supplementation, but pregnant women and babies should receive expert medical advice prior to taking it.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1996) Glaucoma (loose your eye sight)
Date:
February 16, 2009 01:18 PM
Glaucoma is a group of diseases that affect the optic nerve and can lead to irreversible vision loss. It is usually associated with elevated fluid pressure within the eye. All forms of glaucoma can cause damage to the optic nerve and lead to vision loss, even blindness, if left untreated. About 2.2 million Americans have been diagnosed with glaucoma and as many as 2 million more could have it and not yet know. It is one of the lading causes of blindness and is expected to become more prevalent in years to come due to the growing population of older adults. Those people who are at greatest risk for developing glaucoma are people over the age of sixty, people of African ancestry, and people with diabetes, high blood pressure, severe myopia, or a family history of glaucoma. Smokers also have an elevated risk, as do those who have sustained eye injuries or who have used steroids for an extended period of time. About 3 percent of Americans are believed to have open-angle glaucoma, which is the most common form of this disease. Because this disorder causes no symptoms until it is quite advanced, only about half of those who have it are actually aware of it. In open-angle glaucoma, there is no physical blockage and the structure of the eye appear to be normal. However, the drainage of fluid is inadequate to keep the intraocular pressure at a normal level. The most pronounced symptoms of open-angle glaucoma are the gradual loss or darkening of peripheral vision and a marked decrease in night vision or the ability of the eye to adjust to darkness. Other possible symptoms include chronic low-grade headaches, the need for frequent changes in eyeglass prescription, and/or seeing halos around electric lights. A far less common, yet more serious, form of glaucoma is closed-angle glaucoma. Closed-angle glaucoma is much more dangerous than open-angle forms because it almost never manifests any symptoms until very late in the condition. By that time, vision may be irreversibly damaged. Glaucoma probably has many causes, with many scientists believing it may be closely linked to stress and nutritional problems or disorders like diabetes and high blood pressure. Some think that excessive amounts of glutamic acid, which is a nonessential amino acid, may be involved. Glaucoma has also been linked to deficiency in nitric oxide, which is a molecule that is critical for healthy blood vessels. Problems with collagen, the most abundant protein in the human body, have been linked to glaucoma as well. Collagen increases the strength and elasticity of tissues in the body, especially those of the eye. Collagen and tissue abnormalities at the back of the eye contribute to the clogging of the tissues through which the intraocular fluid normally drains. This results in elevated inner eye pressure, leading to glaucoma and related vision loss. The following nutrients are considered to be very important when dealing with and preventing glaucoma: choline, essential fatty acids, glutathione, rutin, vitamin A, vitamin B complex, vitamin C with bioflavonoids, vitamin E, alpha-lipoic acid, magnesium, a multivitamin and mineral complex, and zinc. Additionally, the following herbs are helpful: bilberry, chickweed, eyebright, coleus forskohli, fennel tea, chamomile, ginkgo biloba, zinc sulfate, jaborandi, and rose hips. To resolve issues with the eyes, one must change their diet, exercise, and take supplements and herbs like what are listed above. Medical doctors are at a loss as to how glaucoma happens but they can help stop the progression of this disease if detected early on. Always consult your doctor before adding vitamins and herbs to your diet, vitamins and herbs are available at your local or internet health food store. *Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1966) L-Alanine Non Essential Amino Acid
Date:
January 05, 2009 04:31 PM
L-Alanine is one of 20 amino acids that are used by the body to manufacture the proteins essential for life. Each protein possesses specific biological properties that are imparted by the sequence of amino acids it contains. Proteins control the chemistry that takes place within the cells of our body, and comprise all of the enzymes that catalyze the body's biochemistry. Amino acids are also the building blocks of DNA that determines the genetic make-up of individuals, and that also provides recipes or templates for the production of proteins from amino acid sequences. There is a different DNA template for every protein required by the body that determines which of the 20 amino acids are needed, and in what order they are to be combined with one another to manufacture the desired protein. 10 of these 20 amino acids can be synthesized by your body's biochemistry, the other 10 being essential parts of your diet. If you fail to include just of these 10, then your body will break down its proteins until it has obtained a sufficient supply of that amino acids for its needs. That involves muscle and other tissue degradation, and is one of the symptoms of malnutrition. Amino acids are not stored, and a daily supply is essential to avoid these symptoms. L-Alanine is one of the ten that the body can manufacture, and used by the body to help build protein and also to enable the body to make use of glucose to generate energy. It does so as part of what is known as the glucose-alanine cycle. During anaerobic exercise, such as in weightlifting and sustained running, muscles produce lactate and also alanine. The alanine is passed on to the liver where it is converted to energy via its conversion to glucose. This is not a particularly efficient means of creating energy because a byproduct of the process is urea, the removal of which in turn requires energy. However, it serves its purpose as an energy source once the liver is depleted of glycogen. In fact that is the major use to which alanine appears to be put by the body: the conversion of glucose to energy. The way the glucose-alanine cycle works is that a process known as transamination produces glutamate from the amino groups of amino acids that are degraded during exercise. Glutamate is then converted to pyruvate by means of the enzyme alanine aminotransferase, with the production of alanine and alpha-ketoglutarate. This is a reversible reaction, and after the alanine has been carried by the bloodstream to the liver, the reaction reverses with the regeneration of pyruvate that undergoes gluconeogenesis (generation of glucose). The result of this is glucose that returns to the muscle tissue to provide more energy. The glutamate is broken down to the ammonium ion in the mitochondria, which in turn enters the urea cycle with the production of urea. In a nutshell, then, the glucose-alanine cycle removes glutamate and pyruvate from muscle tissue to the liver where glucose is generated from the pyruvate and returned to the muscle. Since gluconeogenesis involves the expenditure of energy, and this occurs in the liver rather than in the muscle, all the energy in the muscle can be used for muscle contraction. L-Alanine possesses other properties, among them the ability to help maintain the health of the prostate. A study of benign prostatic hyperplasia (enlarged prostate) indicated that treatment with L-alanine, glutamic acid and glycine over a period of three months reduced the symptoms. However, make sure that you consult your physician before using alanine in this way. This is not because there are any known adverse side effects, because there are not, but because it I always wise to so with any supplement taken with a view to treating any medical condition. A less obvious application derives from the fact that it forms a stable free radical when deaminated. Deamination can be initiated by radiation, and so the concentration of this free radical can be measured to ensure that the correct dose of radiation is being given in dosimetric radiotherapy. It is not always easy to control the dose accurately, and this property of alanine allows it to monitored and to ensure that it is neither too low to have the desired effect, nor dangerously high. Although it is a non-essential amino acid, and can be produced by the body, a dietary supply or supplement is advantageous if extra energy is required. Good dietary sources of L-alanine include meats, seafood, eggs, nuts, beans, seeds, brewer's yeast, corn and legumes among others. Supplements are also available, and useful for body-builders, weightlifters and others involved in anaerobic exercise. Due to the glucose-alanine cycle, it can possibly provide energy when lactate build-up would otherwise lead to muscle cramps. Those for whom a supplement could be useful are athletes and others who are trying to build muscle and stamina, or reduce their body fat and also the obese and overweight for the same reason. There is also evidence that a combination of the amino acids alanine, glycine and arginine can help to reduce arterial plaque from oxidized low density lipoproteins, and can also help to reduce high blood pressure. Deficiencies are rare, although groups that do not eat meat should be careful to eat foods with a good alanine content. There are no known side effects of a deficiency since the body will generate what is needed for normal purposes, and while the supplement appears to have no side effects, it is advisable that pregnant and lactating women should first seek medical advice. The same applies if you suffer from hypertension or diabetes. High doses of alanine might also affect those with kidney or liver disease.
Although the benefits of supplementation of L-alanine might not be immediately obvious, the results and the science indicate that it is effective in making better use of blood glucose in that the adenosine triphosphate (ATP) created in the muscle tissue is allowed to be expended on muscle contraction while the glucose-alanine cycle provides the energy needed for gluconeogenesis.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1958) GABA
Date:
August 26, 2008 04:58 PM
GABA is gama amino butyric acid, and is an inhibitory neurotransmitter that is essential for the proper function of your brain and the central nervous system, and has the effect of reducing excessive brain activity and promoting a state of calm. For many people, the rush of daily life, with its problems, worries and external stimuli, can over-stimulate the brain to the extent that it can all seem too much for them. They feel anxious and overwhelmed, and wish that they could just go into a quiet corner to get away from it all. Most people have felt like that at some time, but the demands of life do not allow them that luxury. They just have to bear it and get on with life. That is where GABA can come in. It can be used to bring your nervous system back to base, and make you feel more relaxed, calmer and more able to meet these challenges that life often throws at you. When you feel that you just can’t relax or concentrate on what you are doing, GABA can help you. If you look around you and everybody else seems OK, without apparently feeling the stress and irritability that you feel, and then perhaps your problem is due to a GABA deficiency. GABA is the principal inhibitory neurotransmitter in your brain, and a deficiency would certainly give you the symptoms that you are feeling. Let me explain why. As your brain becomes excited, it can run out of control and needs some form of modification or inhibition to keep it acting as normal. Without this you would become increasingly more restless and irritable, and ultimately have seizures. GABA is not only the main inhibitor in your brain, but also helps in the production of endorphins that provide you with a sense of well being. That sense of calm you feel when endorphins are produced, for example during exercise or sexual intercourse, is commonly referred to as the ‘endorphin effect’. GABA is at its highest concentration in specific areas of the brain, including the hypothalamus, the hippocampus and the central brain area, and is present in up to 40% of all synapses, the small gaps between neurons across which brain cells can communicate with each other. It is produced during the Krebs or Citric Acid Cycle that is responsible for cell respiration or the production of energy from carbohydrates. It is synthesized from alpha-keto glutarate, which is produced just before the Succinyl Co-A stage of the Krebs Cycle in the brain. Vitamin B6 in involved in its metabolism, and a Vitamin B6 deficiency can lead to a deficiency in GABA that might result in seizures. Basically GABA works by inhibiting the firing of neurons in your brain, and thus reducing general brain activity. The GABA receptor allows more chloride ion to enter the brain cell, thus helping to maintain the electrical charge within the cells. Bezodiazepines (e.g. diazepam) work by increasing the effectiveness of GABA in opening the chloride ion cells to allow more chloride ion to enter the neurons, and caffeine does the opposite, and inhibits this property of GABA. Thus diazepam works as a minor tranquilizer and caffeine as a stimulant. Alcohol has a similar effect to the benzodiazepines, increasing the release of chloride into the neurons, and is the major way in which alcohol affects the brain. In fact, tolerance to drugs and withdrawal symptoms can be explained by the receptors adapting to the drug. They may increase in number, which means that more of the drug is needed to work on them, and they can become hypoactive in the event of the drug being withdrawn, that enhances the symptoms that the drug was intended to treat. So basically, that is the way that GABA works. In simple terms it increases the flow of chloride electrolyte to the brain, and in so doing affects our mood. This effect is enhanced by prescription drugs such as Valium and Ativan, which are used by those that suffer the effects of a GABA deficiency. However, these drugs have side effects, not the least of which is dependency due to the GABA receptors becoming modified to suit the drug. There is a more natural way to overcome many stress problems and symptoms of mood swings. Knowing what causes these symptoms, it makes sense to eat foods that stimulate the creation of neurotransmitters to replace those that are deficient. Since GABA is produced in the Krebs Cycle and complex carbohydrates produce glutamine that is an important part of that Cycle, and is also the precursor to GABA, then the consumption of such foods should in theory produce more GABA. In this case the theory works, and you should eat foods rich in complex carbohydrates such as whole grains, brown rice and oats as part of your diet. Other foods that are high in glutamine or its precursors, glutamic acid and glutamate, include citrus fruits, beef liver, broccoli, halibut and lentils. A useful supplement to take is L-theanine, an amino acid found in green tea, and available in supplement form. L-theanine can calm your nerves while maintaining clarity of thought. In other words it calms you down, but doesn’t make you drowsy and allows you to enjoy your day with anxiety. Your doctor can determine whether or not you have a neurotransmitter deficiency through a simple urine test, and might also test your saliva for hormone content. A GABA supplement might be indicated, and if so it other beneficial effects on your body other than its effect on your brain cells. It improves your sleep cycles and promotes vivid dreaming, and can also have a positive effect on your blood pressure. It is also an effective pain killer, and can provide relief from such conditions as back pain and arthritis. Its stimulating effect on the anterior pituitary gland to secrete Human Growth Hormone might also be regarded as a benefit by many. Increasing the level of HGH in your blood can lead to fat loss and improved anabolic activity (increase in muscle tissue). This can be of benefit to older people whose level of HGH secretion has dropped off, and who find it more difficult to lose fat. GABA is a substance that has many known benefits and no known side effects other than a slight tingling and increase in heart rate when the supplement is first used. It has a definite benefit for people to whom the world seems too hectic and overwhelming.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1875) L-Glutathione Can Eliminate Toxins in the Liver
Date:
December 07, 2007 11:54 AM
L-glutathione is the reduced form of glutathione, and is a tripeptide synthesized in the animal and plant tissues from glycine, cysteine and glutamate. Commonly known as GSH, it contains thiol groups that are maintained in a reduced state, and is a very powerful antioxidant, considered to be the key antioxidant and protective substance in the body. Glutathione can reduce any disulfide groups in the cytoplasm within the body of the cell, and ensures that the cytoplasm is a strongly reducing medium protecting against oxidation. It has a synergistic effect with other antioxidants to protect the body against free radicals and oxidizing agents that cause so much damage to the body through what is commonly referred to as ‘oxidative stress’. However, there is more to it than that and it attaches itself to toxic chemicals and drugs in the liver and renders them into a state suitable for elimination from the body. These toxic materials include poisonous pesticides, hydrogen sulfide, carbon monoxide, heavy metals such as mercury, cadmium and chromium and many other substances that we come into contact with due to present day pollution of our atmosphere and foodstuffs. Glutathione can also help protect the body from the effects of chemotherapy and evidence is suggesting possible links with the control of some cancers, diabetes, atherosclerosis and many other degenerative conditions caused by free radical attack and the effects of pollutants. The way that GSH acts in the cells is that the redox state of the glutathione-glutathione disulfide couple is critical to the health of the intercellular and intracellular fluid. GSH in the reduced state of glutathione reacts with an oxidative agent such as hydrogen peroxide to form the oxidized form, glutathione disulfide and water. It hence mops up oxidizers such as peroxides and free radicals within the cytoplasm of the body’s cells, and also in between the cells. The disulfide is then converted back to GSH by the combined action of the enzyme glutathione reductase and NADPH (the reducing agent nicotinamide adenine dinucleotide phosphate). The cycle then repeats so that two molecules of glutathione continue to reduce damaging oxidizing agents without themselves being consumed. In so doing, the NADPH becomes oxidized. A continuous supply of NADPH is needed to allow GSH to undergo these biochemical reactions, and up to 10% of our blood glucose is used by the pentose phosphate pathway by which NADPH is synthesized. Since this cycle consumes no glutathione, it would appear that a supplement is unnecessary. However, this is not the case since the molecule takes part in other reactions in the body, particularly in the elimination of toxic heavy metals from the body. Mercury is highly reactive with the thiol that GSH is, and so will bind to form a stable Hg-sulfydryl bond in the liver. This mercury-glutathione chelate is unable to bind to other proteins or gain access to the body cells, and is eventually harmlessly secreted. The same is true of many other heavy metals that are reactive with thiol’s. In this way the body is protected from the harmful effects of these heavy metals. However, it results in the loss of the glutathione, and the pollution of modern day living can take a heavy toll of the GSH content of our bodies. For this reason a glutathione supplement is recommended, especially for city dwellers that may be exposed to more heavy metals than those residing in rural areas. However, the form in which this supplement is taken is very important, because the human digestive tract contains a significant amount of gamma-glutamyltranspeptidase. That is an enzyme which apparently destroys glutathione before it can be absorbed. However, it can be absorbed directly into the bloodstream by dissolving the pill between the teeth and inner cheek. It has also been suggestion that the supplement could be administered by injection. Others have suggested that rather than administer a supplement, individuals could take other supplements that contain the materials needed to stimulate the formation of GSH. Substances such as vitamin C, selenium (important in GSH biochemistry), methionine, alpha-lipoic acid and glutamine could all help to increase the body’s production of glutathione. A supplement of the constituent parts of cysteine, glycine and glutamic acid should also help. The dosage ranges recommended vary widely from 50mg to 500mg daily, and the effects of supplementation are not yet well know. Some specific conditions that this wonder antioxidant is useful in treating include liver disease such as hepatitis, cirrhosis and so on. Patients suffering from these diseases show a massive reduction in their GSH content and prior GSH treatment appeared to offer a significant degree of protection in controlled clinical investigations. Patients suffering from chronic hepatitis C have been found to be associated with reduced GSH levels, particularly if also HIV positive. Similar deficiencies have been noted in some lung conditions such as asthma and other pulmonary conditions. In such cases it has been demonstrated that administration of GSH supplements sufficient to restore normal levels of the substance improved the patients’ conditions by a significant amount. Its effect on atherosclerosis appears to be significant since a decreased level of GSH peroxidase has been recorded in such patients in addition to an increase in lipid peroxides, indicating that oxidation of the arterial wall had been occurring. Anti-viral therapies that rely on GSH biochemistry for their action have been found to be less effective in those with low GSH levels, and other studies have confirmed that supplementing with GSH improves the response to interferon treatment. These results indicate the activity of oxidizing agents and free radicals in liver conditions, and in fact this has been demonstrated by tests carried out in New York and Philadelphia in the 1990s. This suggests that the liver is prone to damage by oxidative stress, and that GSH levels may be able to be used as an indication of potential liver disease. What is evident is that a strong case can be made for glutathione supplementation as protection against potential liver, pulmonary and cardiovascular diseases, especially by those exposed to specific polluting agents such as primary or secondary tobacco smoke, auto and diesel fumes and chemicals and pesticides. L-glutathione is useful, not only for the elimination of toxins in the liver, but also in protecting this large and vital organ from the oxidative stress that modern living brings. L-Glutathione and its precursors are sold over the counter at your local or internet health food store.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1649) Comprehensive Prostate Formula-the Clinical Studies
Date:
October 13, 2005 04:32 PM
Helps maintain a healthy prostate gland. Supports normal urinary function. Comprehensive Prostate Formula-the Clinical Studies Saw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted over the last fifteen years suggest Saw palmetto extract can produce major improvements in prostate-related urinary function. In clinical studies, Saw palmetto extract has produced measurable improvements in urinary functions and prostate size. Quality of life scores have also improved. The results with Saw palmetto extract have been duplicated in open trials and controlled, double-blind studies.11,12,13 For example, in a large open trial, 505 men took 320 mg of Saw palmetto extract daily for three months.1 The results were evaluated with various measurements such as the International Prostate Symptom Score, the quality of life score, urinary flow rates, residual urinary volume, and prostate size. After 45 days these parameters improved significantly. After 90 days of treatment nearly ninety percent of both the doctors and patients regarded Saw palmetto extract as effective as therapy for the prostate. The changes in prostate health that accompany middle age are related to the hormone DHT, or dihydrotestosterone, a metabolite of testosterone. DHT levels rise, and DHT binds to prostate cells, accelerating growth of prostate tissue. Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an enzyme that controls conversion of testosterone to DHT.14 Experimental evidence suggests Saw palmetto extract blocks the binding of DHT to prostate cells.15 The fatty acids and sterols in Saw palmetto are believed to be responsible for these actions.14,16 These include oleic acid, lauric acid, campasterol, stigmasterol, beta-sitosterol and others. Clinical studies have used extracts containing 85 to 90 percent fatty acids and sterols. Like Saw palmetto, Pygeum contains natural sterols and fatty acids.2 Although the mechanisms for its effect have not been clearly established, animal experiments suggest Pygeum may work by inhibiting prostate cell proliferation and reducing inflammation.17,18 In several European trials, Pygeum has successfully improved urinary function. In a large double-blind, placebo-controlled study, 263 men were given 100 mg of Pygeum extract a day for 60 days. Urination improved in 66 percent of the men taking Pygeum, compared with 31 percent on placebo, based on subjective and objective tests.19 Nettles are approved by the German Commission E as effective for relieving inflammation in the urinary tract.20 As far back as 1950, German investigators have observed favorable effects on the prostate with the use of Nettle root. These initial findings have been confirmed through case studies, as well as double-blind studies, published mainly in German medical journals. In a recent double blind study published in the journal Clinical Therapeutics, 134 men took a combination of Nettle root extract and Pygeum extract over a period of 56 days.3 Urination was significantly improved. L-Alanine, Glutamic Acid and Glycine As noted above, Drs. Feinblatt and Gant discovered that a combination of the amino acids L-alanine, glutamic acid and glycine has a positive effect on prostate-related urinary function.5 A controlled study of 45 men was conducted to follow up on these initial observations.21 The majority of subjects experienced complete or partial relief in urinary complaints such as nighttime urination and urgency.
Scientific References 2. Lawrence Review of Natural Products. Pygeum. Jan 1998. Facts and Comparisons, St. Louis, MO. 3. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses Clinical Therapeutics 1993; 15(6):1011-19. 4. Wagner, H., Willer, F., Samtleben, R., Boos, G. Search for the antiprostatic principle of stinging nettle (Urtica dioica) roots Phytomedicine 1994; 1:213-224. 5. Feinblatt, H.M., Gant, J.D. Palliative treatment of benign prostatic hypertrophy. Journal of the Maine Medical Association, March 1958:99-124. 6. Giovanni, E., et. al. Intake of carotenoids and retinol in relation to risk of prostate cancer. Journal of the National Cancer Institute 1995;87(23):1767-76. 7. Wallace, A.M., Grant, J.K. Effect of zinc on androgen metabolism in the human hyperplastic prostate. Biochemical Society Transactions 1975; 3(3):540-42 8. Badmaev, V., Majeed, M., Passwater, R. Selenium: A quest for better understanding. Alternative Therapies 1996; 2(4):59-67. 9. Fouhad, M.T. Selenium and cancer, chromium and diabetes: two trace elements that have merits as dietary supplements in human nutrition. Journal of Applied Nutrition 1979:31(1&2):14-17. 10. Vescovi, P.P., et. al. Pyridoxine (Vit. B6) decreases opoids-induced hyperprolactinemia. Horm. metabol. Res. 1985; 17:46-47. 11. Tasca, A., et. al. Treatment of obstructive symptomatology caused by prostatic adenoma with an extract of Serenoa repens. Double-blind clinical study vs. placebo. Minerva Urologica e Nefrologica 1985; 37:87-91. 12. Champault, G., Bonnard, A.M., Cauquil, J., Patel, J.C. Medical treatment of prostatic adenoma. A controlled test of PA 109 vs. placebo in 110 patients. Ann. Urol. 1984; 18(6):407-410. 13. Crimi, A., Russo, A. The use of Serenoa repens extract in the treatment of functional disturbances caused by prostate hypertrophy. Med. Praxis 1983; 4:47-51. 14. NiederprŸm, H.J., Schweikert. H.U., ZŠnker, K.S. Testosterone 5 alpha-reductase inhibition by free fatty acids from Sabal serrulata fruits. Phytomedicine 1994; 1:127-133. 15. Sultan, C., et. al. Inhibition of androgen metabolism and binding of liposterolic extract of Serenoa repens B in human foreskin fibroblasts. J. Steroid Biochem. 1984; 20(1):515-519. 16. Weissner, H., et. al. Effects of the Sabal serrulata extract IDS 9 and its subfractions on 5 alpha-reductase activity in human benign prostatic hyperplasia. The Prostate 1996;28:300-06. 17. Yablonsky, F. Nicolas, V., Riffaud, J.P., Bellamy, F. Antiproliferative effect of Pygeum africanum on rat prostatic fibroblasts. J. of Urology 1997; 157:2381-87. 18. Marconi, M. et. al. Anti-inflammatory action of Pygeum extract in the rat. Farmaci. & Terapia. 1986; 3:135. 19. Barlet, A, et. al. Efficacy of Pygeum africanum extract in the treatment of micturational disorders due to benign prostatic hyperplasia. Evaluation of objective and subjective parameters. A multicenter, randomized, double-blind trial. Wien. Klin. Wocheschr. 1990; 22:667-73. 20. The Complete German Commission E Monographs. 1998, Blumenthal, M., ed., (p.216) Austin, TX: American Botanical Council. 21. Damrau, F. Benign prostatic hypertrophy: amino acid therapy for symptomatic relief. American Journal of Geriatrics 1962; 10:426-30.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=838) Prostate Health Naturally
Date:
June 16, 2005 11:11 AM
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Coconut sugar is extracted from young coconut tree flowers and provides the best natural organic sugar and a source of the best alternative to sugar cane based sweeteners and the best solution for people suffering from sugar related conditions such as blood sugar diabetes and heart diseases. Further, coconut sugar is known to reduce incidences of obesity and the bring down the levels of cholesterol in the blood. 
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