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Is NAD+ the "Missing Link" in Modern Longevity Science? Darrell Miller 4/11/26
CuraMed by Terry Naturally Darrell Miller 2/14/24
Ten powerful anti-inflammatory herbs VitaNet, LLC Staff 8/30/18
Foods That Cause Inflammation: 5 Foods to Avoid VitaNet, LLC Staff 8/26/18
Are gut microbes really a panacea, or just overhyped? Darrell Miller 9/22/17
Is there a difference between fresh or frozen fruits and vegetables? Darrell Miller 7/4/17
From golden lattes to wonder drug – is turmeric really such a super spice? Darrell Miller 6/5/17
Remarkable health benefits of moringa Darrell Miller 2/3/17
Does a vegan diet affect your ability to heal? Darrell Miller 1/16/17
Why processed food may cause bowel cancer Darrell Miller 11/22/16



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Is NAD+ the "Missing Link" in Modern Longevity Science?
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Date: April 11, 2026 12:24 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Is NAD+ the "Missing Link" in Modern Longevity Science?


Nicotinamide Mononucleotide (NMN) is a naturally occurring molecule that serves as a direct precursor to Nicotinamide Adenine Dinucleotide (NAD+). As we age, our natural levels of NAD+ decline significantly—by age 50, most people have roughly half the levels they had in their youth. This decline is linked to many of the physiological hallmarks of aging.

How NMN Boosts NAD+ Levels

NMN is essentially a "building block" for NAD+. The process by which the body converts NMN into NAD+ is relatively direct, making it an efficient supplement for raising levels.
  1. Absorption: When NMN is ingested, it is rapidly absorbed from the gut into the bloodstream. Recent research suggests that a specific transporter (Slc12a8) allows NMN to enter cells directly.
  2. Conversion: Once inside the cell, an enzyme called nicotinamide mononucleotide adenylyltransferase (NMNAT) converts NMN into NAD+.
  3. The Salvage Pathway: The body also uses a "recycling" system called the salvage pathway. After NAD+ is used by enzymes, it breaks down into nicotinamide (NAM), which is then converted back into NMN and eventually NAD+ again. Adding supplemental NMN provides the system with more raw material to complete this cycle.

Why Boost NAD+? The Biological Benefits

NAD+ is a "coenzyme" found in every single living cell. It is required for over 500 different enzymatic reactions. Here are the primary reasons why maintaining high NAD+ levels is critical for health:

1. Cellular Energy Production (ATP)

NAD+ plays a starring role in the mitochondria, the powerhouses of the cell. It acts as an electron carrier in the process of turning nutrients from food into ATP (Adenosine Triphosphate), which is the primary energy currency of the body. Without enough NAD+, cellular energy production falters, leading to fatigue and decreased metabolic function.

2. DNA Repair and Stability

Our DNA is constantly under attack from UV radiation, pollutants, and metabolic byproducts. To fix this, the body uses enzymes called PARPs (Poly ADP-Ribose Polymerases). These enzymes are strictly "NAD+-dependent," meaning they cannot function without consuming NAD+. By boosting NAD+, you provide the fuel necessary for cells to repair genetic damage effectively.

3. Activation of Sirtuins (The "Longevity Genes")

Sirtuins are a family of proteins responsible for cellular health, aging, and DNA protection. They are often called "Guardians of the genome."
  • Sirtuins can only function in the presence of NAD+.
  • They help regulate inflammation, protect cells from oxidative stress, and manage how the body responds to fasting and exercise.
  • Low NAD+ levels mean sirtuins remain "dormant," potentially accelerating the aging process.

4. Metabolic Health and Insulin Sensitivity

Research indicates that increasing NAD+ through NMN can improve glucose metabolism and insulin sensitivity. This is particularly relevant for maintaining a healthy weight and reducing the risk of age-related metabolic disorders.

5. Circadian Rhythm Regulation

NAD+ levels fluctuate throughout the day and help regulate the body’s internal clock (the circadian rhythm). Maintaining healthy levels helps ensure that your cells know when to be active and when to undergo repair, which can improve sleep quality and daytime alertness.

Note: While NMN is widely studied in animal models with promising results regarding lifespan and healthspan, human clinical trials are ongoing to fully confirm long-term efficacy and optimal dosage. Always consult a healthcare professional before starting new supplements.

Furthermore:

While the basics of NMN and NAD+ focus on energy and aging, there is a much deeper layer to this "master molecule" that involves cellular theft, "zombie" cells, and the critical importance of a process called methylation.

Here are the vital pieces of the NAD+ puzzle that aren't usually mentioned:

1. The "NAD+ Thieves": CD38 and Inflammation

Boosting NAD+ with NMN is only half the battle; the other half is stopping the "thieves" that steal it.
  • CD38: This is an enzyme that acts as a massive "sink" for NAD+. As we age, our bodies produce more CD38, especially in response to chronic low-grade inflammation. CD38 is incredibly "greedy" - it can destroy up to 100 molecules of NAD+ for every one it processes.
  • Senescent ("Zombie") Cells: These are old cells that refuse to die. They secrete a cocktail of inflammatory proteins (called SASP) that trigger CD38 across the body. This is why NAD+ levels drop so sharply - it’s not just that we produce less; it's that we are destroying it faster than ever.

2. The Methylation Connection (Why you need TMG)

This is perhaps the most important practical detail for anyone taking NMN.
  • When your body uses NMN to make NAD+, it eventually breaks the NAD+ down into a byproduct called Nicotinamide (NAM).
  • To get rid of excess NAM, your liver has to "tag" it with a methyl group so it can be excreted in urine.
  • If you take high doses of NMN without replenishing these methyl groups, you can deplete your "methyl pool." This can lead to fatigue, low mood, or high levels of homocysteine (a risk factor for heart disease).
  • The Solution: Many people take TMG (Trimethylglycine) alongside NMN to provide the body with extra methyl groups and keep the system balanced.

3. The "Double-Edged Sword" of Cancer

NAD+ is essential for all living cells, including cancer cells.
  • Prevention: High NAD+ levels help repair DNA, which prevents the mutations that cause cancer.
  • Fuel: However, recent research (including studies from early 2026) suggests that if a tumor already exists, boosting NAD+ might inadvertently provide the "fuel" the tumor needs to grow or resist chemotherapy.
  • Takeaway: While NAD+ is generally considered safe for healthy individuals, medical experts advise caution and specialist supervision for those with an active cancer diagnosis.

4. Regulatory Status (The 2026 Update)

The legal status of NMN has been a rollercoaster. In late 2022, the FDA initially ruled that NMN could not be marketed as a supplement because it was being investigated as a drug. However, as of late 2025, the FDA issued updated guidance essentially reinstating NMN’s status as a legal dietary ingredient, clearing the way for its continued sale in the U.S.

5. Natural Boosters and "Sirtuin Activators"

Supplementing NMN is just one way to boost the system. You can also:
  • Inhibit CD38: Flavonoids like Apigenin (found in parsley/chamomile) and Quercetin act as natural CD38 inhibitors, effectively "plugging the leak" in your NAD+ tank.
  • The NAD+/NADH Ratio: It isn't just about the total amount of NAD+; it's about the ratio of NAD+ (oxidized) to NADH (reduced). High-intensity interval training (HIIT) and fasting are the most effective ways to naturally "flip" NADH back into the beneficial NAD+ form.
Ultimately, the science of NMN and NAD+ represents a shift from merely treating symptoms of aging to supporting the body’s fundamental cellular machinery. By replenishing the "master molecule" and addressing the "thieves" that drain it, we can effectively fuel DNA repair, boost mitochondrial energy, and activate the longevity-linked sirtuins. However, as we have seen with the necessity of TMG for methylation and the evolving research of 2026, boosting NAD+ is not a "set it and forget it" solution - it is a balancing act. Approaching NMN as one part of a holistic strategy - alongside proper nutrition, exercise, and targeted co-factors—is the most effective way to ensure your cells remain resilient and energized for the long haul.

Are you planning to focus your blog post on the anti-aging benefits for a general audience, or would you like to lean more into the technical "biohacking" side of science?

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6636)


CuraMed by Terry Naturally
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Date: February 14, 2024 05:33 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: CuraMed by Terry Naturally

Experience the transformative power of nature with CuraMed by Terry Naturally, a prized elixir that encapsulates the essence of health and vitality. Imagine a single ingredient, BCM-95® Curcumin, with a heritage spanning centuries, now delivered to you in its most potent and absorbing form. Curcumin, derived from the ancient turmeric root, is revered for its remarkable anti-inflammatory properties and its ability to fiercely protect your cells from oxidative stress and damage.

Step into a story where wellness intertwines with tradition, where each capsule of CuraMed holds the secret of age-old wisdom fused with cutting-edge technology. Feel the comfort of knowing that you're nourishing your body with an extract that's up to 700% more bioavailable than standard turmeric, thanks to the unique process that melds curcumin with essential oils to enhance absorption. Like a golden drop of sunshine, each dose is a concentrated beacon of health.

Envision a life where every day is filled with the vigor you desire. CuraMed by Terry Naturally offers that vitality by maintaining a healthy inflammation response in the body, supporting your joints, brain, heart, and immune system. The power of BCM-95® Curcumin is more than just an antioxidant; it's a commitment to your long-term wellbeing, ensuring that with every capsule, you're paving the path to a vibrant life.

Begin a journey where each morning promises a leap towards wellness. With CuraMed's unparalleled potency, imagine fewer pills and yet feeling the invigorating impact of curcumin flooding through your body, like a wave of restorative energy. It's not just about alleviating the pains of today, but about investing in the joys of your tomorrows.

CuraMed by Terry Naturally isn't just a supplement; it's an ally in your quest for a life brimming with health. Embrace the science of nature with a product that stands apart in its commitment to pure, powerful ingredients designed for maximum impact. Let CuraMed be the Guardian of your health, guiding you to a life where every day feels like a breath of fresh air, clear mind, and a resilient, thriving body.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6594)


Ten powerful anti-inflammatory herbs
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Date: August 30, 2018 03:38 PM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Ten powerful anti-inflammatory herbs





Ten powerful anti-inflammatory herbs

Inflammation in the body is a condition which makes itself known in various clear ways. These include swelling, pain and a mobility loss in the region affected. For an intervention to be effective against inflammation, it would need to address all three of these specific areas, generally by affecting the immune system. Fortunately, there are herbs which do indeed address these particular effects of inflammation. Research has shown that there are specific elements in each of the following herbs that are useful for ameliorating inflammation pain and swelling, and thereby improving motility. These herbs include ginger, spirulina, black pepper and curcumin.

Key Takeaways:

  • Inflammation makes itself known in the body by exhibiting the symptoms of swelling, pain and a loss of mobility to the region.
  • Specific ingredients in natural substances, like piperine, found in black pepper, and gingerol, found in ginger, are anti-inflammatory agents.
  • Other substances with anti-inflammatory action include the herb, curcumin, and the blue-green algae, spirulina.

"To be successful in the management of inflammation with herbs, every attempt has to be made to identify and use herbs that not only deal with inflammation per se, but also those herbs that can take care of individual symptoms."

Read more: https://guardian.ng/features/health/ten-powerful-anti-inflammatory-herbs/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5734)


Foods That Cause Inflammation: 5 Foods to Avoid
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Date: August 26, 2018 05:53 PM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Foods That Cause Inflammation: 5 Foods to Avoid





Foods That Cause Inflammation: 5 Foods to Avoid

Inflammation serves as a guardian of your body warning you to be careful with whatever part is acting up. If inflammation is left untreated, it can cause disease. Eliminating certain foods from your diet can help keep you healthy. Processed meat, like beef jerky or bacon, can cause issues. Foods with large doses of added sugar should also be avoided. Refined carbs and food that contains vegetable and seed oil are also a no-no, as are anything with artificial trans fats.

Key Takeaways:

  • Meat itself contains healthy nutrients, but processed meats like bacon and jerky should be avoided.
  • Too much added sugar can lead to heart disease and mental disorders in addition to inflammation.
  • Choose whole-grain rices, breads, and pastas instead of processed products that cause inflammation,

"While the science behind these diets doesn’t impress most health experts, the ingredients in certain types of foods have been shown to harm the body from the inside out."

Read more: https://www.cheatsheet.com/health-fitness/foods-that-cause-inflammation-5-foods-to-avoid.html/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5724)


Are gut microbes really a panacea, or just overhyped?
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Date: September 22, 2017 09:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Are gut microbes really a panacea, or just overhyped?





Gut microbes and their role in physical as well as mental health has received a lot of attention in the past few years. Researchers are claiming that some day probiotic medicines can be taken to combat disease, both mental and physical. his is not just hype. Serious research is being done to learn how these microbes work on the human body with the hopes of creating probiotic like medications someday. Read here about these recent research advances.

Key Takeaways:

  • Though historically microbial entities have been pointed at as a source of disease, the assumption is not accurate, as only a fraction are truly harmful.
  • Trillions of beneficial, potentially integral to human life, microbes live in the human abdomen in environments scientists call microbiomes.
  • From these internal environments emerge chemicals that influence brain function and development, potentially influencing diseases, like Parkinson's.

"The gut microbiome does indeed show huge potential, but the research is still in its infancy, and many of the big questions remain unanswered."

Read more: https://www.theguardian.com/commentisfree/2017/sep/07/gut-microbes-panacea-brain-probiotic

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5270)


Is there a difference between fresh or frozen fruits and vegetables?
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Date: July 04, 2017 09:14 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Is there a difference between fresh or frozen fruits and vegetables?





People might wonder of there is a difference between fresh or frozen fruits and vegetables. It was believed previously that frozen fruits and veggies do not have as much nutritional value as their fresh counterparts. It was also believed that during freezing, essential vitamins and minerals depleted. There was an article posted at The Guardian's website that stressed today's newer techniques that involve blanching before flash freezing have greatly improved nutrient retention in frozen fruits and veggies.

Key Takeaways:

  • Produce begins to lose essential nutrients as soon as it is harvested, but some studies suggest freezing can preserve produce's nutritional and health value longer.
  • A study examining eight kinds of produce compared fresh and frozen and found no difference in nutritional or mineral content, though some had varying levels of vitamins and riboflavin.
  • Experts have said that frozen and canned vegetables have been processed when most nutritious, while fresh produce can take days or weeks to be cooked and lose more nutrients.

"However, an article published in The Guardian‘s website stressed that today’s newer techniques involving blanching prior to flash freezing have significantly improved nutrient retention in frozen fruits and vegetables."

Read more: http://www.naturalnews.com/2017-07-01-is-there-a-difference-between-fresh-or-frozen-vegetables.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4923)


From golden lattes to wonder drug – is turmeric really such a super spice?
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Date: June 05, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: From golden lattes to wonder drug – is turmeric really such a super spice?





People attribute all kinds of health benefits to turmeric. It is becoming popular because of these. Everyone wants a natural remedy. It is better than taking drugs which often have unpleasant side effects. This gives the scoop on whether or not turmeric is all it's cracked up to be. It's good info because some of these remedies aren't but some really do help a lot. It also helps that turmeric has a great flavor and many enjoy it just for that.

Key Takeaways:

  • In short, turmeric has done a cauliflower – from also-ran to hip ingredient du jour, Google searches for it are up 75% in the last five years.
  • Amazingly, for something with such incredible powers, at under £1 a jar for the powdered stuff, this spice remains cheap, which can’t be said for all the supplements these wellness gurus recommend.
  • Turmeric doesn’t actually taste of very much – bitter, slightly warm (it’s a member of the same family as ginger).

"Is turmeric the magic bullet it’s been claimed to be? Of course not. Might it be beneficial in some way to our health? Very probably"

Read more: https://www.theguardian.com/lifeandstyle/2017/may/31/golden-latte-turmeric-culinary-trends-ingredients-golden-spice

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4775)


Remarkable health benefits of moringa
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Date: February 03, 2017 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Remarkable health benefits of moringa





Moringa is a relatively large tree that is native to North India. It goes by a variety of names, such as drumstick tree, horse radish tree, or ben oil tree. How amazing! Almost all parts of the tree are edible and can be used as ingredients in traditional/herbal medicines. The leaves and pods are commonly eaten in parts of India and Africa. Moringa which is botanically known as Moringa oleifera, is a popular plant known for its rich antioxidant property and its several bioactive content of plant compounds.

Key Takeaways:

  • Ever heard about the mystical miracle plant or the plant referred to as ‘the tree of life’?
  • These are the descriptions given to the remarkable Moringa plant as a result of its numerous health benefits.
  • This mystical plant has been in existence for over hundreds of years.

"Ever heard about the mystical miracle plant or the plant referred to as ‘the tree of life’?"



Reference:

https://www.google.com/url?rct=j&sa=t&url=//Guardian.ng/features/remarkable-health-benefits-of-moringa/&ct=ga&cd=CAIyGjVkYjY3ZDViNDdiNGM3ZTc6Y29tOmVuOlVT&usg=AFQjCNE8Cxv7nn0fs3gKPVfT0UjYcMNc1w

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3875)


Does a vegan diet affect your ability to heal?
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Date: January 16, 2017 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Does a vegan diet affect your ability to heal?





For all you vegans out there what if I told you being a vegan may give you the ability to heal faster? Sounds crazy I know but recently a once vegan man survived a brutal plane crash. There is no proof of this but some researches and scientist believe this may be true.

Key Takeaways:

  • Only two people survived on September 19, 2008, celebrity disc jockey DJ AM and Blink-182 drummer Travis Barker, when a plane attempting to takeoff from the Columbia Metropolitan Airport in South Carolina had blown a tire and were unable to stop the plane on the remaining runway.
  • Travis Barker, a vegan at the time, suffered second- and third-degree burns over his torso and lower body. He was taken to the Joseph M. Still Burn Center in Augusta, Georgia, where, he told the Guardian in an interview several weeks after the crash, he had to eat 6,000 calories a day in order to speed his recovery.
  • Giving up veganism, in this case, came with an added health benefit: Early in his hospital stay, his doctors reportedly had trouble getting his skin grafts to take, which Barker said in interviews was due to his low levels of protein; after a while on his new high-calorie diet, they had more success.

"The pilots, who thought that they had blown a tire, were unable to stop the plane on the remaining runway they had left."



Reference:

//www.cnn.com/2017/01/03/health/vegan-diet-healing/index.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3791)


Why processed food may cause bowel cancer
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Date: November 22, 2016 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Why processed food may cause bowel cancer





Researchers at Georgia State University has found a link between emulsifiers used to keep food fresh and bowel cancer. By feeding mice two common emulsifiers found in preserved food, they found that their instances of bowel inflammation increased and created an environment in which cancer is more likely to occur. It is believed that the chemicals alter the bacteria of the gut and allow bad bacteria to grow, which causes inflammation.

Key Takeaways:

  • Common additives used in everyday foods including bread, margarine and sweets may be behind the huge rise in bowel cancer, scientists claim.
  • Emulsifiers, which are added to most processed foods to aid texture and extend their shelf life, alter gut bacteria in the stomach.
  • Crohn’s disease and ulcerative colitis, two of the most common forms of the disease, are known to aid tumour growth.

"Common additives used in everyday foods including bread, margarine and sweets may be behind the huge rise in bowel cancer, scientists claim."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//Guardian.ng/features/why-processed-food-may-cause-bowel-cancer/&ct=ga&cd=CAIyGmZmMDFkMTU2YWMzMmQ5OTU6Y29tOmVuOlVT&usg=AFQjCNFqWZiNEVxHpexbzms1yTW84w8Cww

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3488)



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