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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) Is Your Cinnamon Causing Inflammation? The Hidden Risks of a Common Spice 
Date:
July 16, 2026 05:28 PM
Cinnamon is widely praised for its ability to improve cellular glucose uptake and support insulin sensitivity, but the direct answer is yes - under specific conditions, consuming cinnamon can cause or trigger inflammation. While cinnamon naturally contains powerful anti-inflammatory polyphenols (like cinnamaldehyde), its potential to drive inflammation boils down to two distinct triggers: the specific variety you ingest, and your individual immune response to its volatile oils. 1. Coumarin-Induced Liver InflammationThe primary metabolic risk stems from Cassia cinnamon, which is the standard, inexpensive variety found on most grocery store spice racks. Cassia contains significant concentrations of a naturally occurring compound called coumarin.
2. Contact Hypersensitivity (Cinnamon Stomatitis)Cinnamaldehyde gives cinnamon its signature warmth and flavor, but it is also a documented contact allergen.
3. Gastrointestinal Mucosal IrritationBecause concentrated spice powders contain highly concentrated volatile oils, taking large doses on an empty stomach can physically irritate the delicate mucous lining of the upper gastrointestinal tract. This localized chemical irritation can mimic or exacerbate inflammatory discomfort in the stomach wall, resulting in heartburn, acid reflux, or cramping.Mitigating the Risk: Ceylon vs. CassiaIf you are leveraging cinnamon as a daily tool for metabolic health and blood sugar management, switching to Ceylon cinnamon (often labeled as "True Cinnamon") fundamentally changes its biochemical impact.
While cinnamon is highly regarded for improving insulin sensitivity and managing blood sugar, it can paradoxically trigger inflammation under specific conditions. The primary systemic risk stems from Cassia cinnamon, the common grocery store variety, which contains high concentrations of a compound called coumarin. When consumed regularly or in large therapeutic doses, coumarin can overwhelm the liver's metabolic pathways, leading to elevated liver enzymes and acute hepatic inflammation. Beyond liver toxicity, cinnamon can also incite localized inflammation; its volatile oil, cinnamaldehyde, can induce a Type IV delayed hypersensitivity reaction known as contact stomatitis - causing painful burning and swelling in the mouth - while concentrated doses can physically irritate the gastrointestinal lining. To safely harness the metabolic benefits of the spice without triggering these inflammatory responses, switching to Ceylon cinnamon ("true cinnamon") is the most effective strategy. Systemically, Ceylon contains only trace, negligible levels of coumarin (0.004% to 0.007%), making it safe for daily medicinal dosing, whereas Cassia contains significant levels (up to 1.0%) that require strict consumption limits to avoid toxicity. Visually and structurally, the two varieties are distinctly different: Ceylon features a light tan color with multiple thin, fragile, and tightly rolled layers, while Cassia is characterized by a dark reddish-brown hue and a single, thick, hard quill that is difficult to break.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6645) Magnesium Glycinate: An In-Depth Guide
Date:
November 04, 2023 10:53 AM
Magnesium Glycinate: An In-Depth GuideMagnesium is an essential mineral for the body, playing a crucial role in the regulation of blood pressure and numerous other bodily functions. The shortcoming of this nutrient can be addressed through the consumption of magnesium glycinate, a supplement also known as magnesium diglycinate and magnesium bisglycinate. Key Roles of Magnesium
This article delves into the details of magnesium glycinate, looking at its benefits, potential side effects, the recommended dosage, and more. Benefits of Magnesium GlycinateThe human body needs a significant amount of magnesium for optimal function. Although the best way to obtain nutrients is in their natural form, supplements like magnesium glycinate are available to enhance magnesium intake in individuals with low levels. Benefits of this supplement include:
Precautionary Measures
Conditions that may Benefit from Magnesium Glycinate
Sources of Magnesium Glycinate Nutritional sources rich in magnesium include legumes, nuts, seeds, whole grains, spinach, fortified breakfast cereals, yogurt, milk, and other dairy products. Recommended Dosage The amount of magnesium glycinate to be taken can vary. It is advised to consult a doctor before starting a magnesium glycinate regimen. Potential Side Effects Magnesium glycinate, like other dietary supplements, can cause side effects such as nausea, abdominal cramps, and diarrhea when taken in large or frequent doses. However, a study from 2013 indicated that magnesium glycinate is less likely to induce diarrhea compared to other magnesium supplements. Extreme doses could lead to magnesium toxicity, resulting in more severe side effects. Easy Ways to Consume More Magnesium One effective method of increasing magnesium intake is by incorporating dietary supplements into your daily regime. For instance, Solaray Magnesium Glycinate is a popular supplement that is widely recognized for its efficacy. It is an easily digestible form of magnesium that is gentle on the stomach and less likely to induce diarrhea. Solaray's supplement provides an accessible option for those looking to supplement their diet with magnesium, especially for individuals who might struggle to meet their nutritional requirements through diet alone. Conclusion Magnesium glycinate can be a beneficial supplement for individuals with magnesium deficiency. However, caution must be exercised in its consumption, with potential side effects and individual health conditions taken into account. As always, it is best to seek medical advice before starting a new supplement regimen.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6587) Modified citrus pectin helps to reduce heavy metal toxicity by 74percent, study says
Date:
April 25, 2019 04:54 PM
As you may know, heavy metals are everywhere, in our water, food, dental fillings, and air. Fortunately, according to the latest research, modified citrus pectin is a substance that can help to safely remove these toxic metals from the body. The accumulation of heavy metals in the body not only can lead to chronic disease, but it also compromises the body's ability to heal from illness. Some common toxic heavy metals are lead, mercury, and cadmium. To reduce your body's burden of heavy metals, take 15 grams of the product PectaSol three times a day. Key Takeaways:
"Mercury, a known neurotoxin, is found in fish such as swordfish and shark, as well as in “silver” dental fillings. The crazy part is: we know that mercury can seriously affect the nervous system, causing tremors, loss of coordination, muscular spasms and even death." Read more: https://www.naturalhealth365.com/modified-citrus-pectin-2824.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6187) Study: PQQ (pyrroloquinoline quinone) may prevent and even reverseAlzheimer's
Date:
January 04, 2019 08:12 AM
Pyrroloquinoline quinone (PPQ) is a microbe that is derived from plants, and it is showing to have neurological benefits that are associated with the prevention of Alzheimer's progression. This particular microbe is able to reduce inflammation in the brain, which can lead to several neurological conditions. It also helps patients in post-stroke recovery because it is able to reduce the area of the brain that is impacted by stroke activity. Most importantly, it helps in the prevention of Alzheimer's due to how it can neutralize levels of oxidative stress. Key Takeaways:
"Glutamate is an important chemical in the brain, but too much of it results in excitotoxicity, a risk factor in both stroke and neurodegenerative disease. PQQ protects the brain from overstimulation by glutamate and the resulting death of brain cells." Read more: https://www.naturalnews.com/2018-12-15-ppq-can-prevent-alzheimers.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5928) Say NO to GMO in America
Date:
December 05, 2016 10:18 PM
Coming from over 50 countries, countless millions of people have expressed their disapproval over attempted corporate ownership of plant seeds through GMO (genetically modified organisms). Having said that, the corporations involved have assured the public that GMO is safe and want us to believe that it's more efficient at feeding the world by giving higher yields and have greater resistance to extreme weather conditions. Safety of GMOAccording to a growing number of scientists such as world leading expert Dr Don Huber GMO expert, professor of plant pathology at Purdue University, Lafayette, Indiana, USA, there has been NO peer reviewed evidence to support the idea that GMO crops are safe. On the contrary, a vast catalogue of scientific evidence has built up over the years showing that GMO is unsafe.Public consumption of genetically modified crops have been accused of causing ill health in the form of allergies, cancer, birth defects and infertility. It also includes toxicity, reduced nutritional value, environmental damage and political unrest such as that with farmer's and consumer's disputes. The Revolving Door EffectApproval bodies like the FDA (Food and Drug Administration) decide whether or not a food or drug is fit to go out on the market for consumption. GMO is not safe. Nor has it shown to produce higher yield, greater nutritional value or resist drought conditions better than non-GMO according to many experts such as Professor John Fagan, award-winning Geneticist, Maharishi University of Management, Iowa, USA.Yes, of course we should say NO to GMO. It is spurred on by corporate greed and political self interest with more than its fair share of hidden ulterior motives. The technology is unimaginably potentially dangerous and could be perceived as one of the biggest threats to humanity if allowed to get out of control.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3577) Warning: 4 common vitamins no one told you become toxic if you take too much
Date:
October 28, 2016 03:59 AM
Vitamins are used to enhance your life when you're not eating the right foods. Many vitamins are sold in which you can use to gain these necessary vitamins and minerals. But, before you head out to the vitamin store to make a purchase, take a look at these four common vitamins that, when taken in too large of a quantity, can be toxic. Key Takeaways:
"Excess of some vitamins can cause problems due to toxicity, although far fewer people experience side effects from multivitamin pills compared to the number affected by prescribed medications. Even so, as Goldilocks might have said, it’s important to obtain not too much, not too little, but just the right amount."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3340) Are Laxatives Safe For Your?
Date:
April 26, 2014 10:03 PM
Herbal laxatives could promote bowel activity with mild purgation. They are usually used when there is a blood toxicity, constipation, an infection that cleansing of people bowel is needed, insufficient fiber in diet, a skin condition which caused by insufficient elimination, gallstones or hypertension. Common laxatives The most common laxative herbs used are senna, cascara sagrada, sesame, psyllium and milkweed. Milkweed or Asclepias syriaca is an old home remedy for warts, and medicinally important in heart disease treatment. The seed of Psyllium contain copious amounts of the mucilage, which are able to treat constipation, diarrhea and act as an effective and safe weight loss aid. Why Would You Use Laxatives? For relief of constipation you might suppose to use laxatives. Constipation is a gastrointestinal disorder, which make result in fewer or difficult bowel movements. Low fluid or fiber intake is the common causes of constipation. You will discover that bulk-forming laxatives are usually recommended for first aid when you have a constipation problem that will draw fluid into your intestines. However, it is not recommended to use laxatives in long-term, because it could give you harmful side effect. The Pros and Cons of Taking Laxatives Laxatives were used for conditions like irregularity, painful elimination and hard stools. For temporary use laxatives are help to treat some chronic condition and invaluable. However, using laxatives for long-term use may give you several risks: cramping, bloating, nausea, gas and diarrhea. The most important risk you might want to know, is your body will be dependent on that herbs. It is an important option to consult to your doctor when having a risk of laxatives. Since there are some risks of using laxatives, you would like to try the alternatives of laxative when you are planning to use in a long term. Here are some valuable alternatives: Fiber rich food, drink plenty of water daily and exercise regularly.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3105) How Does Passion Flower Help Me Relax ?
Date:
April 07, 2011 01:39 PM
Passion flower refers to a group of flowering plants that belongs to the genus Passiflora, comprising of up to 500 species. The commonly known plant species of Passiflora are climbing vines with a woody stem system although there are a few herbaceous shrubs. They are found across the globe with the exception of arctic and sub-Saharan regions and easily recognizable by their unique flower structure which often contains prominent styles and stamens. Passiflora incarnata, or more commonly known as Maypop in the vernacular, has a long association with folk medicine of American Indians, who use various parts of the plant as a relaxant. Different species of Passiflora are called different names, but the trivial name passion flower pertains to the corona that resembles the crown of thorns worn by Jesus. Moreover, the Christians have ascribed many symbolisms for the intricate parts of the flower. For example, the ovary is believed to represent the Holy Grail. Early European settlers in the Americas discovered the calming effects of teas made from Passiflora species through the Indians, and popularized its use against anxiety soon after in Europe. Produces Tranquilizing Effects Several studies have investigated the effects of passion flower on human health, with a few comparing it to the drug exazepam. Its mechanism of action is still under scrutiny, but scientists are convinced that its sedative effects are very similar to the herbs Valeriana officinalis and Piper methysticum. More often than not, it is used in combination with these two herbs. As a mild relaxant with a slow onset of action, Passiflora incarnata, or Maypop, have been documented to benefit individuals suffering from irritability, insomnia, and agitation. In conjunction with a drug called clonidine, it also appears to relieve muscle tremors. Increases Inhibitory Brain Chemicals It has long been postulated that passion flower works on the principle of raising the levels of inhibitory neurotransmitters, such as gamma-aminobutryric acid, or GABA. Glutamic acid, the biological precursor of gamma-aminobutyric acid, has been linked to neuronal excitotoxicity that leads to many known diseases of the nervous system. By aiding the metabolic pathway responsible for converting glutamate into gamma-aminobutyric acid, passion flower not only increases the amounts of the chief inhibitory brain chemicals in the human brain and the rest of the central nervous system, but also lowers the levels of excitatory neurotransmitters. This results in a drop in neuronal activities and a reduced risk of excitotoxicity, which translated into a more relaxed feeling. Alleviates Physical Fatigue Passion flower is known to counter the harmful effects of stress. In addition to alleviating psychiatric symptoms of anxiety, Passiflora incarnata has also been tied to the treatment of muscle weakness characteristic of fibromyalgia. It is one of the herbal nervines used in combination with other herbal adaptogens in combating physical fatigue due to long hours at work and the consequent sleep deprivation. Fortunately, passion flower is generally considered safe and nontoxic, with dosages equivalent to food proportions in general. Passion flower can be taken with valerian and skull cap to help calm the mind and body when under intense stress. Give it a try and See for yourself!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2267) What is Vinpocetine and How Does it Help with Memory?
Date:
March 24, 2011 02:18 PM
Vinpocetine And Brain HealthVinpocetine is a derivative of an organic compound found in the plant species Vinca minor, or common periwinkle. It is best known for its neuroprotective effects and used in Europe and Japan in treatment of age-related cognitive decline. More often than not, its activities inside the human body are described as vasodilator, which means it increases blood flow. It has also seen a growing presence in the North American market as a dietary supplement. Vinpocetine is available as a prescription drug in certain European countries and Japan and has shown to be speed up prognosis of patients who suffered cerebrovascular accident, or CVA, which is commonly referred to as stroke. Most cases of cerebrovascular accident are brought on by ischemia, or very poor circulation of blood to certain parts of the brain. This is exactly what vinpocetine is beneficial for, and recommended dosages have so far yielded very encouraging results. Improves Blood Circulation in the Brain It has long been postulated that one of the mechanisms of action of vinpocetine is limiting the effects of Na+ channels that are sensitive to voltage. This creates a neuroprotective effect believed to contribute to mental clarity and sustained attention. Striatal nerve endings produce extracellular Ca+ ions that induce neuronal damage through a phenomenon called excitotocity. High levels of Ca+ ions are now alleged to be correlated with voltage-sensitive Na+ channels. Striatal nerve endings see a decline in Ca+ ions when Na+ channels are influenced by vinpocetine, and in the process lessen excitotoxicity. Attenuates Ischemic Neuronal Damage In addition to limiting neuronal damage induced by excitotoxicity, which in turn results from cerebral ischemia, vinpocetine plays an active role in the upkeep of brain cells after being subjected to ischemic damage. As a vasodilator, it not only counters the effects of ischemia but also significantly increases the brain’s access to bioactive molecules like oxygen and other nutrients exclusively distributed by the circulatory system. It also inhibits the enzyme phosphodiesterase, which is specialized for the breakdown of cyclic adenosine monophosphate, or cAMP, and cyclic guanosine monophosphate, or cGMP. By so doing, vinpocetine contributes to glucose metabolism and energy production in the brain, and at the same time, improves the distribution of bioactive compounds in the central nervous system. Displays Neuroprotective Activities Vinpocetine and its precursor belong to a group of indole alkaloids known as tryptomines, which are present in the human brain and the rest of the central nervous system in minute quantities. These organic compounds make up several psychoactive drugs and in the human body act as neuromodulators and neurotransmitters in the form of melatonin and serotonin. Vinpocetine in particular displays activities that are primarily anti-inflammatory in nature. Several studies point to its effects on the enzyme complex called IkB kinase, which regulates cellular responses to inflammation, by preventing the translocation of a protein complex called responsible for the process of inflammation within cells. In a Nutshell, vinpocetine can help you think clearer and protect the brain from inflammation and free radical damage. Give vinpocetine a try today!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2257) How to detoxify from heavy metal aluminum toxitity
Date:
November 09, 2010 06:04 PM
When aluminum salts accumulate in the brain, seizures and reduced mental function can often result. In order to reach the brain, aluminum must pass the blood-brain barrier, which is an elaborate structure that filters the blood before it reaches the vital organ. Although elemental aluminum does not ordinarily pass through this barrier, certain aluminum compounds, such as aluminum fluoride, will. Many municipal water supplies are treated with aluminum sulfate and fluoride. These two chemicals readily combine with each other in the blood and are poorly excreted in the urine. The absorption of high levels of aluminum and silicon in the intestines can result in the formation of compounds that accumulate in the cerebral cortex and prevent nerve impulses from being carried to and from the brain in the proper manner. This situation can be aggravated by a chronic calcium deficiency. People who have spent their career in aluminum smelting plants for long periods have been known to experience dizziness, impaired coordination, and a loss of balance and energy. When aluminum accumulates in the brain, the above symptoms are often caused. Perhaps the most alarming thing to note it that there is evidence to suggest that long-term accumulation of aluminum in the brain may contribute to the development of Alzheimer’s disease. It has been estimated that an ordinary person ingests about 3 and 10 milligrams of aluminum a day. Aluminum, being the most abundant metallic element in the earth’s crust, is primarily absorbed in the body through the digestive tract, but can also be absorbed through the lungs and skin. Additionally, aluminum can be absorbed by and accumulate in the body tissues. Since aluminum permeates our air, water, and soil, it can be found naturally in varying amounts in almost all food and water. Aluminum is also used to make cookware, cooking utensils, and foil, along with being present in many other everyday products including over-the-counter painkillers, anti-inflammatories, douche preparations, antacids, baking powder, food processing, antiperspirants, toothpaste, dental amalgams, bleached flour, grated cheese, table salt, beer, and municipal water supplies. The following nutrients are very helpful when dealing with aluminum toxicity: apple pectin, calcium, magnesium, coenzyme A, garlic, kelp, lecithin capsules or granules, l-glutathione, a multivitamin and mineral complex, SAMe, vitamin B complex, N-Acetyl Cysteine, and vitamin E. Additionally, the following herbs are great for blocking damage to the body from toxic heavy metals and radiation when taken regularly: burdock root, Echinacea, ginseng, ginkgo biloba, and fiber. Other recommendations to help prevent aluminum toxicity include maintaining a diet that is high in fiber and includes apple pectin; using only stainless steel, glass, or iron cookware, with stainless steel being the best; and being aware of the products that contain aluminum by reading labels and avoiding those that contain aluminum. Sulfur container foods like N-Acetyl Cysteine can help find up heavy metals and eliminate them from the body. If you suspect you have heavy metal toxicity, consult your health care provider immediately. ~facebook~
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2195) Kava Kava Root
Date:
September 05, 2009 12:11 PM
Kava is an ancient crop of the western Pacific. The word kava refers to both the plant and the beverage that is produced from its roots. Kava is a tranquilizer that is primarily consumed to relax the body without disrupting mental clarity. The active ingredients found in this herb kavalactones. Kava extract is marketed as an herbal medicine in some parts of the Western world, fighting against stress, insomnia, and anxiety. It has been concluded that this herb is more effective than a placebo at treating short-term social anxiety. Safety concerns have been raised over liver toxicity, but research indicates that this may be largely due to use of stems and leaves in supplements, which were not indigenously used. Kava is used by many island communities in the Pacific in their ceremonial drinks as a mild sedative and relaxant. Among these include Polynesia, Micronesia, and Melanesia. This herb was used to relax the body and mind and to promote restful sleep. Kava is considered to be an important herb for pain relief. It is also helpful for insomnia and nervous conditions. This herb is recommended to be used as a strong muscle relaxant. It is considered to be one of the most powerful of all of the herbal muscle relaxants. Kava is used as an analgesic sedative, for rheumatism, for insomnia, and to relax the body. Studies have determined that kava contains anticonvulsant and muscle-relaxing properties. This may be extremely helpful to those people who have stress-related muscle tension or seizures. Those individuals who drink kava often relate the effects to a sense of tranquility and sociability. The herb helps to achieve a feeling of well-being and relaxation. Kava seems to have an advantage over other drugs that are prescribed for anxiety and insomnia because it does not seem to lose effectiveness over time. A variety of studies have shown that there is a significant benefit for individuals who are suffering from anxiety. This is extremely promising for those individuals who require long-term therapy for anxiety disorders. Kava is not addictive and is free of associated complications. This is different from many of the medications that are routinely prescribed. Kava also provides benefits as an analgesic for pain relief. The chewed leaves of this herb cause numbness in the mouth. This anesthetic activity is similar to cocaine and it lasts longer than benzocaine. The root of the kava plant is used to provide alterative, analgesic, anesthetic, antifungal, antiseptic, antispasmodic, aphrodisiac, diuretic, and sedative properties. The primary nutrients found in this herb are calcium and magnesium. Primarily, kava is extremely beneficial in dealing with insomnia and nervousness. Additionally, this herb is very helpful in treating anxiety, asthma, bronchitis, fatigue, pain, rheumatism, uterine infections, vaginitis, and venereal diseases. It is important to consult your health care provider before taking this herb so that you do not have any adverse reactions to medication which is associated with this herb. In order to obtain more information on the many beneficial effects provided by kava, please feel free to contact a representative from your local health food store.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2074) ChickWeed
Date:
June 16, 2009 09:46 AM
Chickweeds are an annual herb that can be found growing in temperate zones, artic zones, and throughout. The most likely origin of this plant, although not known for sure, is Eurasia. Chickweeds have established themselves all over the world, as they may have been carried by clothes and shoes of explorers. Chickweed plants are as numerous in species as they are in region. Most species are succulent with white flowers. All of the species have practically the same edible and medicinal values. This plant exhibits an interesting trait, as it folds its leaves over its buds and the new shoots every night. This event is known as the sleeping of the plant. Cultivating this plant is not exactly necessary, as it is abundant and easy to find. The plant can be gathered fresh and edible between May and July, as soon as the flowers appear. Not only can the plant be used fresh, it can also be dried for later herb use. Chickweed can be found growing abundantly in areas of Europe and North America. The Ojibwe and Iroquois Native American tribes used chickweed as eyewash. They also used it in poultice form to heal wounds. It has recently been studied for its abilities in helping to prevent cancer. Chickweed is extremely valuable in treating blood toxicity, fevers, and inflammation. Its mucilage elements are known to help with stomach ulcers and also inflamed bowels. Chickweed is great for helping to dissolve plaque in blood vessels as well as other fatty substances that can be found in the body. Chickweed acts as an antibiotic in the blood, as it may be recommended as an anticancer treatment. Some people have used chickweed to treat tumors. Chickweed can be used as a poultice for boils, burns, skin diseases, sore eyes, and swollen testes. Chickweed is also recommended to aid in weight loss and to break down cellulite. This herb is mild and has been sued as a food as well as a medicine. Chickweeds are very nutritious and high in vitamins and minerals. They can be added to salads or cooked as a pot herb. The plant tastes somewhat like spinach. The whole plant can be taken internally as a postpartum depurative, emmenagogue, glactogogue, and cirucaltory tonic. A decoction can also be used externally to treat rheumatic pains, wounds, and ulcers. Chickweed can be applied as a medicinal poultice to relieve any kind of roseola. It is effective wherever there are fragile superficial veins or itching skin conditions. The entire chickweed herb is used to provide alterative, anorectic, antineoplastic, blood purifier, demulcent, diuretic, emollient, expectorant, febrifuge, mucilant, nutritive, pectoral, and stomachic properties. The primary nutrients found in this herb are calcium, copper, iron, manganese, phosphorus, sodium, vitamins C, D, and B-complex, and zinc. Primarily, this herb is extremely beneficial in dealing with excessive appetite, bleeding, blood impurities, convulsions, obesity, skin rashes, and ulcers. Additionally, chickweed can be extremely helpful in treating arteriosclerosis, asthma, bronchitis, bruises, bursitis, colitis, constipation, cramps, eye infections, gas, hemorrhoids, lung congestion, excessive mucus, pleurisy, blood poising, swollen testicles, inflamed tissue, water retention, and wounds. For more information the many beneficial affects of chickweed, please feel free to contact a representative from your local health food store with questions. Chickweed is available in capsule and tablet forms at your local or internet health food store. Look for name brands like Solaray, Natures Answer, and Natures Herbs to ensure quality and purity of the products you purchase. *Statements contained herein have not been evaluated by the Food and Drug Administration. Chickweed is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2018) Cat's Claw Bark
Date:
December 19, 2008 09:54 AM
We are currently living in a time when vital health issues that greatly affect our families are a huge concern. Cat's claw has been shown to offer a huge array of therapeutic actions, as it is currently drawing a huge amount of attention in health-care. Because cat's claw has anti-tumor, anti-inflammatory, and anti-viral capabilities, it is currently being widely used in Europe for the treatment of cancer, aids, arthritis, and several other degenerative diseases. Cat's claws emergence could not have been better timed, as many people feel that the war on cancer is being lost, with new potentially fatal viruses continuing to evolve and the over-prescription of antibiotics making us even more vulnerable to infection. Recently, taking supplements such as cat's claw is becoming more of the rule than the exception. It is safe to say that almost all of us want to know how to reduce our risk of cancer, protect ourselves from toxins and pollutants, boost our immune system to fight off new viral strains and bacterial diseases, and prevent premature aging and degenerative diseases. Additionally, many of us have found that treating the disease after the fact is much less desirable than the protecting our immune systems, as a well-nourished and healthy immune system can keep us from developing diseases, including cancer. Cat's claw has the ability to fortify immunity, works to scavenge free radicals, and eases inflammation. Cat's claw was traditionally used by Peruvian natives in a variety of applications. They apply its leaves for headaches, use teas for infections including influenza, and have placed plants in antipyretic baths for fevers. Additionally, gargles are used frequently and poultices of the boiled crushed bark have been applied to affected areas. Peruvian tribal medicine has also vigorously rubbed infusions of the raw bark on parts of the body, such as the limbs. The vines of cat's claw are often macerated with a pestle or stems are allowed to stand in water for several hours. In Peruvian culture, snuffing or smoking the dried leaves or bark occurs on occasion. Also, enemas are used in some regions of the tropical South America, but they are relatively rare in the Amazon. Cat's claw can be taken in many forms including a dried, powdered form that is usually available in gelatin capsules; compressed tablets; a decoction or tea; or a liquid suspension that are in the form of gels or extracts, which can often be taken in soft gelatin form. Some experts seem to think that cat's claw extracts have not yet proven their potency and therefore, they recommend taking reliable sources of the plant which use the inner bark of the vine. The alkaloid content of some plants can vary significantly because of many different factors, so only reputable sources of cat's claw are recommended to be purchased. Many studies that have taken place in Europe have shown that cat's claw has extremely low toxicity, even when it is taken in large doses. Anyone who has had a transplant or any pregnant or nursing women should not take cat's claw. Taking cat's claw can potentially cause diarrhea or adjust bowel consistency in some people.
If one is looking for a immune boosting herb from the Amazon look no further, cat's claw can help the sick get well and keep the healthy person free from disease by boosting the immune system.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1950) Benefits - Supports joint function and tissue health*
Date:
December 11, 2006 03:46 PM
To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage. Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3 Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3 Promotes optimal joint comfort, function and flexibility* Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4 Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7 Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8 Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11 Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results. Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption* Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14 Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability. Sustained Release – For lasting joint comfort and convenient dosing To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day. Safety Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.
Scientific References 2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68. 3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149. 4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7. 5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146. 6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002. 7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5. 8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers. 9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46. 10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7. 11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308. 12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34. 13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232. 14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J. 15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1438) Hypoallergenic Free Form Amino Acids
Date:
September 07, 2006 01:29 PM
Free form amino acids are hypoallergenic (extremely non-allergic). Many sources of animal and plant proteins cause allergic reactions. Amino acids are molecularly pure and appropriate for the lactose intolerant and those who suffer from a variety of food allergies. Protein toxicity is a common problem for athletes, especially bodybuilders who create serious liver and kidney conditions due to over consumption and malabsorption of protein. To protect against protein toxicity, free form amino acids are used instead of protein, or as a digestive aid to improve assimilation of food protein.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1372) How Does It Work?
Date:
July 08, 2006 01:24 PM
Proprietary Probiotic blend Acidophilus Pearls is a probiotic dietary supplement designed to help support digestion and a healthy intestinal system. Probiotics, such as lactobacillus acidophilus and Bifidobacterium longum are live microbial food supplements that are non-toxic and do not cause disease (non-pathogenic). Probiotics do not permanently colonize in the body. Therefore, they need to be ingested regularly for their health-promoting effects to persist. After ingestion, probiotics must adhere to the wall of the intestine. Once attached to the intestinal wall, the bacteria are capable of multiplying and colonizing in the gut, thereby enhancing the immune response. 1-3 Oral probiotics help support the composition and metabolic activities of the large intestine micro flora.1 Micro flora of the large intestines assist digestion through fermentation (making the intestines inhospitable to invading species), protection against pathogenic bacteria, and stimulation of the development of certain components of the immune system.3 Lactobacillus acidophilus and Bifidobacterium longum occupy a central role in the guy micro flora, thereby enabling them to influence the composition of the micro flora to provide health benefits.4 Breakdown of Lactose Lactose is an important sugar that is converted to lactic acid by lactic acid producing bacteria (such as lactobacillus acidophilus and Bifidobacterium longum).6 Lactose intolerance results from an inability to digest lactose.7 Lactose intolerance may be due to genetics, age related declines in intestinal lactase (the enzyme that metabolizes lactose), or other reasons.8 Lactase deficient people accumulate non-absorbed lactose in the gastrointestinal tract, which draws water and electrolytes into the gut and accelerates transit time, which can lead to diarrhea.2,8 Lactic acid bacteria can help metabolize the non-absorbed lactose in the gastrointestinal tract. In a randomized, controlled clinical trial, Bifidobacterium longum was shown to support the breakdown of lactose and reduce the symptoms of lactose intolerance (flatulence) in people with lactose intolerance.5 Immune system support While a normal micro flora is associated with good health, changes in intestinal health are associated with altered immune function. A well-functioning gastrointestinal immune system mediates immune responsiveness at mucosal sites and throughout the entire body via the control of quality and quantity of foreign substances gaining access to the immune system.9 Lactobacillus acidophilus and Bifidobacterium longum have shown to possess immunoprotective/immunomodulatory properties. These benefits include modulation of: cytokine and various interleukin production, autoimmunity, natural killer cells cytotoxicity, lymphocyte proliferation, and antibody production.3 In an open, randomized, controlled trial, Lactobacillus acidophilus and Bifidobacterium bifidum were supportive of colon health in older adults. In addition, B cell (important antibody producing immune cells) levels increased as compared with the untreated group. The probiotics were very well tolerated, with no significant side effects or variations in clinical chemistry or hematologic parameters. Decrease Occasional Constipation Constipation is defined as infrequent or difficult defection that can result from decreased motility of the intestines. It is a common problem, particularly in older adults. When the feces remain in the large intestine for prolonged periods, there is excessive water absorption, making the feces dry and hard.7 Insufficient amounts of lactobacillus acidophilus and Bifidobacterium longum may play a role in delayed bowel movement, which can favor the activity of undesireable putrefactive bacteria (bacteria that break down organic matter into potentially harmful compounds) in the intestines. Lactic acid bacteria contribute to the re-establishemtn of healthy intestinal flora (at the expense of pathogen growth) and stimulation of intestinal peristalsis via lactic acid. 10 Support of putrefactive Processes When unbalanced conditions are present in the intestines (ie, unbalanced diet, high acidity, and/or low levels of lactic acid bacteria), organic matter may be putrified (decomposed or rotting) by certain bacteria and produce harmful substances such as ammonia.1,11 Micro flora or the large intestines promote homeostasis (balance) in both the intestine and the vagina.1,12,13 these activities are carried out via support of direct production of antibodies, competition with adhesion to intestinal cells, or indirect modulation of the immune system.2 Support Digestion Normal micro flora of the large intestine help support and complete digestion via fermentation.1,11 The risk of diarrhea, for example, increases when the capacity of colonic micro flora to ferment carbohydrates decreases.8 Oral ingestion of probiotics produces a stabilizing effect on the guy flora.2 Additional Benefits The benefits of probiotics extend beyond digestion support and immune support. Lactobacillus acidophilus and Bifidobacterium longum also help support the better utilization and bioavailability of nutrients, including vitamins, minerals, proteins, fats, and carbohydrates.14 Candida albicans is a fungus that is a naturally occurring component of normal gastrointestinal micro flora.15 however, C. albicans should be maintained at healthy levels. Probiotics have been shown to help retain healthy levels of C. albicans that are already within normal limits. True Delivery Technology Recently, our Enzymatic Therapy laboratory tested four leading probiotics nutritional supplements in the marketplace. These supplements were best selling brands, two of the supplements were enteric coated, and all had label guarantees about potency (guaranteed number of live bacteria). The laboratory scientist counted the levels of living bacteria found in compared these findings to the bacterial levels claimed by each manufacturer. The products were also subjected to a simulation of stomach acid conditions, after which the levels of living bacteria were re-counted. The laboratory results found the probiotic supplements contained less than 50% of the number of living bacteria that they clamed on their labels. Furthermore, the laboratory results found that only 10% of the liver bacteria clamed on the manufacturer’s label survived the simulated stomach conditions. Acidophilus pearls used a revolutionary proprietary “pearl” encapsulation process called True Delivery Technology. The True Delivery Technology is a special type of natural coating that protects the probiotic bacteria. The True Delivery is a seamless “pearl”, which consists of three layers. The inner layer is a paste of probiotic bacteria suspended in a protective oil suspension. The second layer actually “seals” the bacteria in the capsule, which protects them from air, moisture, and the effects of heat. Probiotic bacteria are anaerobic organisms (grow in the absence of oxygen) and the presence of oxygen can actually injure or kill them. Because probiotic bacteria are injured or destroyed by the acids of the stomach, the third, outermost layer of the pearl is specially developed to only dissolve in the alkaline environment of the intestines. This patented gelatin pearl protects the probiotic bacteria from the acid environment of the stomach, so that they can successfully reach the intestine. The patented seamless pearl capsule of Acidophilus Pearls assures the virtually all the bacteria remain uninjured and healthy to colonize in the intestine. In addition, the special pearl capsule’s ability to seal the bacteria inside it eliminates the need for the nutritional supplement to be refrigerated – though they can be kept in the refrigerator, if desired. Storage recommended Store at controlled room temperature, 59 degrees F to 86 degrees F (15 – 30C). May refrigerate if desired This statement has not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1328) Curcumin - Turmeric Extract
Date:
August 19, 2005 12:47 PM
Turmeric- History and Traditional Usage
Native to Southeast Asia, Curcuma longa is a tall
In addition to its
Turmeric is named in
Protects cells and tissues by fighting free radicals.* Supports joint function*
The numerous beneficial
Curcumin demonstrates Animal studies- In vivo protective effects
Through its free radical scavenging Human Trials
Curcumin exhibits free-radical scavenging ability when
Bioperine-Nature’s Absorption Enhancer
Traditional Ayurvedic herbal
Curcumin is poorly absorbed in the intestinal Scientific References
© 2002 *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=734) HERBAL FORMS
Date:
July 12, 2005 09:48 AM
HERBAL FORMS
NOTE: Most health food stores stock this herb under the name of Milk Thistle, however, it may also be found as Thisilyn, Silymarin or Silybum STORAGE: Keep in a dark container in a cool, dry environment. REGULATORY STATUS:
US: None RECOMMENDED USAGE: Because Silymarin is not very water soluble, decoctions are not as effective as extracts and powder forms of Milk Thistle. The advantages of bound silymarin should be investigated. Obtaining the best results with Milk Thistle depends on taking higher dosages three times daily before meals. For bound silymarin, dosages are less. In cases where poisoning or alcoholism is severe, dosages may be increased without toxicity, side effects or allergic reactions. Alcohol based extracts are not recommended. The best forms of Milk Thistle are guaranteed to contain 80% silymarin. NOTE: A new form of silymarin has recently become available, which may be even more absorbable than other types. It is silymarin that has been bound to phosphatidycholine. Apparently this binding makes silymarin compounds more clinically effective in the body. SAFETY: No contraindications are associated with this herb even in substantial dosages. Milk Thistle has been extensively used in Europe and numerous studies have shown very little if no toxicity. Taking silymarin can p roduce looser stools, although the effect is not that common. At high dosages, it may be desireable to add a source of fiber to the diet to prevent loose stools or digestive tract irritation. Suggested fibers include: psyllium, oat bran or pectin. Long term use of Milk Thistle poses no problem because of its non-toxicity. The long-term safety and advisability of the use of Milk Thistle extracts in pregnant or nursing women has not been established.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=578) Modified Citrus Pectin (MCP) and Mercury Cleansing Programs... 
Date:
June 21, 2005 05:02 PM
Modified Citrus Pectin (MCP) and Mercury Cleansing Programs by Isaac Eliaz, M.D., M.S., L.Ac. Modified Citrus Pectin (MCP) is a dietary supplement derived from the peel and pulp of citrus fruit. MCP is mostly known for its positive effects on cellular health. Recently, however, clinical research on MCP has produced exciting results for its use as a gentle chelator (eliminator) of mercury and other heavy metals. Some of the expanding clinical applications for MCP include: The Problem with Mercury Recent news on mercury is particularly concerning for the U.S. population. In March 2004 the EPA issued a press release reporting nearly all fish contained traces of mercury. Some samples contained levels high enough to harm an unborn baby or young child's developing nervous system. These findings prompted the EPA to issue a warning to women who may become pregnant, pregnant women and nursing mothers advising them to eat only two meals of fish per week that are thought to have lower levels of mercury.1 In their most recent update (August 2004), the EPA issued a warning that 1/3 of the nation's lakes and 1/4 of its river ways are contaminated with toxic levels of mercury and other contaminants, and warned pregnant women and children against consumption of fish from these sources. Additionally, a National Academy of Sciences panel definitively warned that some children who had been exposed to mercury while in the wombs of their mothers were at risk for becoming those children "who have to struggle to keep up in school and who might require remedial classes of special education." The risk of mercury toxicity from fish has reached epidemic levels. Two studies have further spurred on the concerns of mercury toxicity, as they both found women to have mercury levels that are 8-10% above what is considered safe.1,2 Furthermore, women who ate more fish were found to have higher levels of mercury. Another source of mercury toxicity may be amalgam dental fillings. Heavy metals, in conjunction with the abundant presence of environmental toxins and xenoestrogens, constitute a dangerous insult to the body through DNA damage, hormonal modulation, immune suppression, oxidative stress, and cellular irritation. A New Application for MCP Use: Heavy Metal Detoxification The standard western medical approach for removing mercury from the body to treat mercury toxicity is chelation. This procedure is performed with harsh chelators that can cause multiple side effects while potentially robbing the body of some of its essential nutrients. While this may be the routine and most beneficial procedure when facing a serious toxicity problem, are there other, gentler ways to reduce mercury levels? Two recent clinical studies have found that MCP may be a promising new dietary solution for reducing heavy metal load. In one recent clinical study, MCP was administered to a group of volunteers, and baseline levels of their total body mercury burden were measured and then compared against levels after treatment with MCP (15 grams of PectaSol® daily) for four months. The results showed a significant average decrease (over 60%; p=0.03) in the total body mercury burden after treatment with MCP3 In an earlier study, PectaSol® was given to patients and proven to increase urinary secretion of heavy metals such as lead, mercury, cadmium and arsenic.4 Both studies concluded that MCP may be a promising alternative to the harsher intravenous chelating therapies as MCP was found to be both effective and free of any side effects. How MCP Works as a Gentle Chelator Pectins are natural gelling agents, binders, thickeners, and stabilizers in foods. They mostly consist of galacturonic acid and galacturonic-acid methyl esters with average molecular weights from 50,000 to 150,000 daltons. High-methoxy (HM) pectin has at least 50% DE (degree of esterification) or greater, while a low-methoxy (LM) pectin?s DE is 50% or less. For systemic chelation of heavy metals, pectin is modified to a low molecular weight, and low-methoxy content. My observation from using MCP as a detoxification agent in my clinic is that it works as a gentle chelator in the bloodstream and it is very useful for ongoing use. Because fish are still recommended as part of a healthy diet and an essential source of certain nutrients (essential fatty acids like DHA), mercury levels are also becoming a widespread health concern. It is a Catch-22 for dietary health. As the widespread environmental cleanup of mercury is unlikely in the short-term, the medical community should develop methods to treat toxicity or reduce high body levels of mercury body burden. One approach is the use of traditional and alternative medicine cleansing programs along with the use of dietary supplements such as MCP that may act as gentle chelators. For chelation purposes, 5-15 grams of MCP should be taken per day depending on mercury levels for one year. Maintenance at 2-5 grams per day thereafter is usually sufficient. In my practice, I use 15 grams per day or 15 grams per day in the first 3-5 days of the month and 5 grams per day for the remainder of the month. MCP is generally regarded as safe and is well tolerated. Reported side effects have been rare, but may include mild and transient gastrointestinal discomfort. References: 1-CDC Press Release: Blood and Hair Mercury Levels in Young Children and Women of Childbearing Age-United States, 1999 (see:/media/mmwrnews/n010302.htm#mmwr3) 2-Schober, SE, Sinks, TH, Jones, RL et al. (2003) Blood mercury levels in US children and women of childbearing age, 1999-2000. Journal of the American Medical Association. 289(13) :1667-74. 3-Eliaz, I. (2004) Modified citrus pectin (MCP) in the treatment of cancer. Paper presented at: The American Chemical Society Annual Meeting; Philadelphia, PA. 4-Eliaz, I. and D. Rode (2003). The effect of modified citrus pectin on the urinary excretion of toxic elements. Fifth Annual Conference of Environmental Health Scientists: Nutritional Toxicology and Metabolomics, University of California, Davis.
-------------------------------------------------------------------------------- Isaac Eliaz, M.D., M.S., L.Ac., is a pioneer in the field of integrative medicine and founder of Better Health Publishing®, an education-based company that provides health care professionals, consumers and other interested parties with scientific research on integrative medicine. He is a respected author, clinical practitioner and frequent guest lecturer on integrative medical approaches to health, immune enhancement and cancer prevention and treatment. Since 1991, Dr. Eliaz has maintained a busy private practice in Sebastopol, California, and is the current medical director of the Amitabha Medical Clinic and Healing Center (email:information@amitabhaclinic.com) which focuses primarily on integrative and holistic protocols for cancer patients as well as those with chronic health challenges.
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Laxatives
Although aluminum is not a heavy metal, it can be toxic if present in excessive amounts or small amounts if it is deposited in the brain. Many of the symptoms of aluminum toxicity are similar to those of Alzheimer’s disease and osteoporosis. 
