Search Term: " SUPPRESSED "
Can aloe vera be used to treat sepsis?
May 10, 2019 10:42 AM
Aloe vera can be used for plenty of skin conditions, but new evidence suggests it could be used for blood infections, because of the metabolites in the plant. A Chinese and Japanese study looked at this using mice, and found that aloe metabolites suppressed inflammation, due to reduced nitric oxide level. This is important because sepsis harms the body's own tissues and organs, and can be fatal. Aloe also has other uses, such as skin care, warding off cancer, treating digestive issues, and lowering blood sugar levels.
"After using various tests to determine inflammation, the Chinese and Japanese research team found that aloe metabolites suppressed the expression of inducible nitric oxide synthase (iNOS) and mitogen-activated protein kinases (MAPKs). Aloe metabolites also decreased the production of proinflammatory cytokines and nitric oxide."
Read more: https://www.naturalnews.com/2019-04-17-can-aloe-vera-be-used-to-treat-sepsis.html
Omega-3 intake found to substantially slow brain "aging" byboosting nutrient circulation to memory-related brain regions
April 11, 2019 01:16 PM
Our brains are the most important thing we could ever possess, so why not take something that helps naturally assist it’s function. Omega-3 is the main focus of this article and centers on new evidence found that an aging brain can be somewhat suppressed by consuming some good ole omega-3. It quickly touches on two specific studies and their findings concerning the size of one part of the brain. Additionally, it outlines a few extra benefits of the vitamin and the importance of striking a good bodily balance.
"The researchers found that people who had higher blood levels of certain omega-3 fatty acids – namely ecosatrienoic acid, stearidonic acid, and ALA – had a bigger frontoparietal cortex and therefore performed better on fluid intelligence tests."
Read more: https://www.naturalnews.com/2019-02-13-omega-3-intake-found-to-substantially-slow-brain-aging.html
Medical benefits of cannabis SUPPRESSED and banned throughout mostof the 20th century
March 23, 2019 10:59 AM
Cannabis sativa, otherwise known as marijuana, has been used as a natural medicine for thousands of years, prior to the development of western civilization. However, with the introduction of synthetic pharmaceutical drugs, governments deemed marijuana as evil and dangerous. By the 1930s, the U.S., England, and Canada all outlawed marijuana. However, over the last twenty years, there has been an overwhelming amount of cannabis research out of Spain, Israel, and Brazil, uncovering the human body’s endocannabinoid system and identifying marijuana as the new powerhouse drug of this century.
"By making cannabis “illegal,” governments of the West paved the way for Big Pharma to take over and declare its poisons as the only safe and effective medicine out there – “medicine” that, in some cases, was derived and synthesized from the very same cannabis plant that, under Schedule I designation, was deemed to have no legitimate medical use."
Read more: https://www.naturalnews.com/2019-01-20-medical-benefits-of-cannabis-suppressed.html
Could CBD oil be used for bone disorders ?
September 28, 2017 12:14 PM
Cannabidiol oil, or CBD oil, has the potential for use as a treatment of osteoarthritis, inflammatory joint pain, and other related joint pains. CBD is valuable in this regard because it has the potential to, by attaching to CBD1 and CBD2 receptors present in the joints of mammals, reduce the inflammation and pain that patients experience. However, there is still a need for more research. CBD is confirmed to have the potential to solve the issues of pain and inflammation suffered by those with OA, and possibly even prevent OA from developing at all, but as of yet there has been no testing of CBD as a treatment for OA and joint pain.
"In musculoskeletal disease models, systemic administration of CBD suppressed the progression of collagen-induced arthritis by reducing inflammatory cytokine production."
Read more: http://mmjreporter.com/could-cbd-oil-be-used-for-bone-disorders-31091.html
WARNING: Sugar destroys your body's ability to absorb these 5 essential nutrients
March 26, 2017 11:59 AM
If you consume too much sugar, it affects your body in many ways. It increases risk of certain health conditions, but it also causes your body the inability to absorb nutrients very important for you to maintain to be at your best. These five essential nutrients aren't getting into your body the way they need to be if you are eating a diet filled with sugary substances. You need to fight back and get your body back.
"ncreased glucose levels appear to inhibit vitamin C from entering the cells, thereby resulting in limited vitamin absorption. Sugar-induced vitamin C deficiency may result in suppressed tissue regeneration and decreased immune function."
Read more: http://www.naturalnews.com/2017-03-23-warning-sugar-destroys-your-bodys-ability-to-absorb-these-5-essential-nutrients.html
Research Proving Cannabis Kills Cancer Cells Safely has been Suppressed Since 1974
March 15, 2017 08:59 AM
In 1974 the NIH working with the DEA sponsored research to prove that cannabis caused destruction of brain cells and suppresses the immune system. The research was cancelled and documents were destroyed when it was found it actually enhanced the immune system as well as destroyed cancer cells. Studies are now being sponsored overseas with promising results. Cannabis, when vapors instead of smoked kills cancer cells and city's off blood supply to the cells. There us even a case if a baby cured if brain cancer without surgery or radiation. Standard oncology treatments kill healthy cells as well as cancer while cannabis kills only cancer cells. The research should be allowed in the US with federal funding.
"After several attempts to get cannabis oil allowed through the court system with many testimonials from those who had been helped, Rick realized this important harsh reality: The cancer industry does not want a cure for cancer."
Anti-aging 'Holy Basil' herb supports natural detoxification
January 27, 2017 02:59 PM
Anyone who loves Italian food is probably aware of basil. Hindus actually view the plant as sacred and use it in many religious ways. However, Western herbalists are just now beginning to understand the power this herb has to detoxify and hold off aging. Indians already use basil to help with immunity and stress. It is this stress-relieving property that they believe to be the cause of its anti-aging properties. It also seems to have an effect on cortisol in the body. There is still much research that needs to be done on the subject.
"According to Ayurveda, holy basil can be used to boost mood, stamina and endurance by filling the body with a calming energy. It can help speed up slowed digestion or free up SUPPRESSED emotions."
vitamin d influences longevity by working at genetic level
November 07, 2016 09:54 AM
We know that constant badgering from our doctors saying that Vitamin D or any of the recommended vitamins are important to take but did you know that taking Vitamin D may help produce longevity in your life by working at the genetic level? A new study in worms shows that Vitamin D SUPPRESSED protein insolubility and prevented the toxicity.
"Excess vitamin D can raise blood levels of calcium which leads to vascular and tissue calcification, with subsequent damage to the heart, blood vessels and kidneys."
Green Coffee Bean Extract
November 22, 2012 10:31 PM
Many studies have been carried out to establish the health benefits of Green coffee bean extract for several years. It was just in 2012 that some group of scientists revealed a particular study that demonstrated Green Coffee Bean Extract‘s effectiveness in contributing to weight loss. Leading this study was Dr Joe Vinson, a scientist from the University of Scranton. On the same note, sixteen over-weight people also participated in the study. They were all given varying doses of the Green Coffee Bean Extract for a period of 22 weeks.
These participants lost around 17 pounds when the study ended. They did not report any side effect. Moreover, they were under no exercise plan or diet change during the period of study. The coffee powder that people normally use is prepared after roasting some green coffee beans. The extract is obtained from green coffee bean at a temperature of about 70°C for 2 hours using 70 percent of ethanol. A green coffee bean extract is a yellowish brown hygroscopic powder that has high polyphenols levels referred to as hydroxycinnamic acids, which contains caffeic and chlorogenic acids.
Green coffee bean extract and weight loss
A Japanese scientist, known as Hiroshi Shimoda, did a research about the green bean extract and discovered that it facilitates body weight loss. The weight loss is brought about by some two natural chemical compounds found in the green coffee bean. Since coffee beans are not roasted, they still have their natural chemicals that can otherwise be lost if they are roasted.
The two natural chemicals are chlorogenic acid and caffeine which jointly lead to loss of weight. The caffeine in coffee works by stimulating the release of fatty acids from the fats stored inside the body. The chlorogenic acid, on the other hand, helps the liver to process the released fatty acids thus resulting in weight loss. If one consumes 1kg of food containing 10g of green bean extract daily for 14 days, then the increase in weight can be SUPPRESSED by about 35 percent.
Other Health Benefits of Green coffee bean extract Anti-aging Benefits
The chlorogenic acids in green coffee bean destroy any free radicals formed within the body through metabolism. If such free radicals are left, they can destroy the cell membrane and trigger some ageing symptoms. By destroying such harmful radicals, green coffee bean extract actually slows down the natural aging process. Some studies also reveal that the absorption capacity for oxygen radicals by the green coffee extract is twice that of green tea or grape seed extracts.
Reduce Blood Pressure
Animal research also reveals that chlorogenic acids in the green bean extract helps in alleviating high levels of blood pressure. Considering the results of this particular study, some research was further conducted on human beings. This experiment, performed on people with mild hypertension, revealed that the consumption of the green coffee extract supplement contributed in lowering high blood pressure levels. When a dose of about 185mg of green coffee extract supplement was consumed, the extract proved quite effective in reducing symptoms of hypertension. Hence they are often used for the treatment of the same.
Using Cherries to Deal with Arthritis
May 25, 2011 03:41 PM
Call it what you will: arthritis, osteoarthritis, rheumatoid arthritis or gout - cherries can deal with it and enable you live and sleep more comfortably than without them. When the bones and lubrication systems of your joints become worn you begin to feel pain - not because your bones are grinding against each other but because of the inflammatory response of your immune system.
Your cartilage begins to wear and your body reacts to the damage first by activating cells already close by - macrophages, mastocytes, dendritic cells and so on, and then calls on the release of leukocytes such as neutrophils. Your blood vessels dilate to enable the large cells to get to the general area of the problem, and then leak to enable fluids to get right to the exact spot where they are needed.
With arthritis, the joint swells because of the above actions, and the synovial fluid can become infected and inflamed. The temperature around the joint increases in temperature to render it less attractive to invading cells and pathogens, and you feel pain because of the pressure on your nerve endings. Then you should take some cherry extract.
The activity of the cytokines and prostaglandins that are creating this situation is SUPPRESSED, and the temperature starts to drop. The blood vessels are contracted and the situation begins to return to normal. One more bout of inflammation successfully dealt with, and now that you understand what has caused it you will be better placed to get the cherry extract down your throat next time.
Buy It And Try It Today!
Melatonin, What is it, Sleep And How it Helps!
December 22, 2010 03:20 PM
What is Melatonin?
Melatonin, or N-acetyl-5-methoxytryptamine, is a hormone secreted during the hours of darkness by the light-sensitive pineal gland located in the brain and also by bone marrow, epithelial cells and lymphocytes. Melatonin plays a role in the human circadian cycle because of the fact that it is secreted only when it is dark. It can therefore be used to treat sleeping disorders, although it also affects conditions such as fibromyalgia and depression.
Melatonin is also a powerful antioxidant, particularly protecting the DNA from free radical oxidation and studies have indicated a potential application in inhibiting the aggregation of amyloid beta protein in the brain that promotes Alzheimer's disease. It not only reduces the production of cholesterol in the gall bladder, but also increases the rate of conversion of cholesterol to bile, thus reducing the amount available for oxidation in the arteries that leads to atherosclerosis.
A melatonin supplement is also believed to be an effective treatment for migraine and helps the gall bladder to expel gallstones, rendering them less likely to become a problem.
Melatonin and Sleep
Melatonin is a hormone that is secreted mainly by the pineal gland, a small pea-sized gland in the brain that is sensitive to light in that it secretes this hormone only during the hours of darkness. For this reason, melatonin can be used to help people sleep earlier and awake earlier, by shifting the circadian cycle to an earlier time.
An interesting factor learned from the effect of light on melatonin is that it is SUPPRESSED only by blue light (460-480 nanometers) and by wearing blue filtering glasses it is possible to achieve the same effect as taking a supplement of the hormone. That is, to sleep earlier and waken earlier.
People suffering jet lag, or who have to adapt to differing shift work patterns, benefit by taking melatonin, and it has also been used in helping with benzodiazepine withdrawal and helping people to stop smoking. You must let your doctor know you are using it, and in many countries it is available only by prescription.
October 29, 2009 12:56 PM
The pennyroyal herb is a member of the mint genus. It is an essential oil that is extracted and used in aromatherapy. Crushed pennyroyal leaves and foliage give off a very strong spearmint fragrance. Traditionally, pennyroyal is used as culinary herb, folk medicine, and abortifacient. This herb was commonly used by the Greeks and Romans as a cooking herb. The Greeks often flavored their wine with pennyroyal. Additionally, a large number of the recipes in the Roman cookbook of Apicius use pennyroyal along with herbs such as lovage, oregano, and coriander. Although it was still commonly used for cooking in the Middle Ages, it slowly fell out of use as a culinary herb. Today, it is seldom used. However, the essential oil of pennyroyal is extremely high in pulegone, which is toxic volatile organic compound, and is therefore poisonous to the liver and can stimulate uterine activity.
Pennyroyal was brought by European settlers to the New World. There, they found that Native Americans were using the American variety of pennyroyal for repelling insects, skin irritations, and many of the same illnesses that they were using their own variety for. Additionally, this herb was used to soothe the stomach and relieve cold symptoms. The pennyroyal that is found in America has similar properties to the herb that is found in Europe. However, the European variety is thought to be much more potent.
This herb possesses a volatile oil that works to remove gas from the stomach. It can be consumed as a tea of used as a footbath. If it is taken a few days before menstruation is due, it can help increase a SUPPRESSED flow. The pennyroyal tea is beneficial in relieving cold symptoms and also promoting perspiration. This herb has a strong, minty odor. It is used externally to repel insects like fleas, flies, and mosquitoes.
The oil of the pennyroyal plant is extremely concentrated and is often linked to toxic results. The oil is often associated with abortions and convulsions that result in death. It is believed that the oil irritates the uterus, which causes uterine contractions. The action is not predictable and is potentially dangerous. It is recommended that the oil be used only externally as a natural insect repellant. This herb is suggested for use as a decongestant for coughs and colds. Tea that is made from the pennyroyal herb is not associated with toxicity. In fact, it helps to relax the digestive tract and soothe the stomach.
In short, the entire pennyroyal plant is used to provide alterative, antispasmodic, antivenomous, aromatic, carminative, decongestant, diaphoretic, diuretic, emmenagogue, nervine, oxytocic, parasiticide, sedative, stimulant, and stomachic properties. Primarily, pennyroyal is extremely beneficial in treating bronchitis, childbirth pain, colds, colic, uterine cramps, fevers, gas, lung infections, and absent menstruation. Additionally, this herb is very helpful in dealing with convulsions, coughs, abdominal cramps, delirium, earache, flu, gout, headaches, leprosy, measles, migraines, mucus, nausea, phlegm, pleurisy, pneumonia, smallpox, sunstroke, toothaches, tuberculosis, ulcers, uterine problems, and vertigo.
In order to obtain the best results when supplementing with this, or any herb, it is important to consult your health care provider before beginning any regimen. For more information on the many beneficial effects provided by pennyroyal, please feel free to consult a representative from your local health food store with questions.
Nopal Prickly Pear And Your Health
August 18, 2009 12:41 PM
Nopal is also referred to as the prickly pear cactus. The broad, thick, succulent leaves of the cactus are used for medicinal purposes. The nopal prickly pear herb is the most commonly found in the southwestern United States.
The nopal prickly pear is a vegetable that is made from the young cladophyll, pad-like, segments of the prickly pear plant. These are carefully peeled to remove the spines. The nopal prickly pear is extremely common in its native Mexico. Although the pads of almost all Opuntia species are edible, farmed nopales are most often of the species Opuntia ficus-indica. Generally, a nopal is sold fresh, bottled, or canned. Less often, it is sold dried. It is used to prepare nopalitos. The nopal has a light, slightly tart flavor, and a crisp, mucilaginous texture. This herb is commonly used in Mexican cuisine dishes include huevos con nopales, which is eggs with nopal; carne con nopales, also known as meat with nopal; or tacos de nopales. Nopales are also an important ingredient in New Mexican cuisine. Currently, the nopal is gaining popularity elsewhere in the United States.
De-thorned nopal stems are used as food in Mexico and among Native Americans. Early settlers used the stems in wound dressing after they had been peeled. The gel that comes from the cactus pads was used to soften the skin. This lessened tension against the wound and alleviated pain. Nopal juice is valued as an anti-inflammatory diuretic. Practitioners of folk medicine recommend this herb fore use against painful urination. The mashed pulp of the cactus was traditionally eaten by the West Coast Indians in order to ease childbirth. Additionally, the pulp was used as a lung remedy and as a cardiac aid.
The nopal prickly pear herb contains a variety of phytochemicals. Among these components are pectin, mucilage, and gums that assist the digestive system. This herb also contains nutrients which inhibit bowel absorption of dietary fat and excess sugars. Nopal is responsible for fortifying the liver and pancreas. This enhances insulin’s ability to move glucose from the blood into the cells, where it is able to produce energy. Research has determined that nopal prickly pear has hypoglycemic benefits as well. This could be extremely helpful for those people suffereing from diabetes. Other studies have determined that nopal lowers serum levels of LDL cholesterol and triglycerides. Additionally, it may inhibit cancer growth and prevent cancer development. Laboratory animals that were treated with cactus juice showed an increase immune response regarding tumor growth, Epstein-Barr virus, and SUPPRESSED immune function.
The leaves of the nopal plant are used to provide antiasthmatic, astringent, laxative, pectoral, and vemrifuge properties. The primary nutrients found in this herb are mucilage, pectin, and phytochemicals. Primarily, nopal is extremely beneficial in dealing with cancer, diabetes, high cholesterol, and immune function. This herb also acts as a great digestive aid.
In order to obtain the best results when supplementing with this, or any herb, it is important to consult your health care provider before beginning any regimen while on medications. For more information on the many beneficial effects provided by nopal prickly pear, please feel free to consult a representative from your local health food store with questions.
Polyphenols is an Antioxidant
October 13, 2008 02:14 PM
A lot of new evidence suggests that consuming more plant polyphenols is a powerful way to protect aging arteries. These polyphenol compounds help improve endothelial function, a critical factor in preventing atherosclerosis; inhibit abnormal platelet aggregation which causes most sudden heart attacks and strokes; fight inflammation; and support healthy blood lipids. Polyphenols that are of particular interest are those derived from green tea, cocoa, apples, and black chokeberry, which all complement each other in helping to build the body’s defenses against various ailments.
All throughout history, the medicinal potential of plants has been celebrated. Modern science has found that edible plants are to be valued for their high vitamin and fiber along with their rich store of polyphenols. Polyphenols are found in fruits and vegetables, as well as cocoa, tea, and chokeberry and have been shown to be a type of chemical that may protect the body against some common health problems as well as certain effects of aging. Polyphenols protect cells and body chemicals against damage that is caused by free radicals and block the action of enzymes that cancers need for growth, deactivating substances that promote the growth of cancer. The increased consumption of polyphenols has been associated with a reduced risk of cardiovascular disease and potentially cancer and stroke.
In Aztec culture, cocoa was one of the most highly prized due to its medicinal and stimulant value, along with its taste. The polyphenols found in cocoa occur in a higher concentration than can be found in any other food. They also have antioxidant activity much greater than those found in broccoli or red wine. The catechins and procyanidins that are found in cocoa seem to lower the risk of cancer and heart disease. Cocoa has also been proven in studies to reduce blood pressure, improve insulin sensitivity, and slightly ameliorate the lipid profile. Although cocoa is a healthy and tasteful food, it is high in caloric content and therefore, its ingestion must be accompanied by the careful reduction of calories from other sources.
Many studies have shown that tea polyphenols can be extremely beneficial to human health, possessing anti-obesity, antihypertensive, anti-diabetic, antioxidant, anti-inflammatory, and anticancer effects. Tea is the world’s second most consumed beverage, although less popular in the Western diet. Green tea and white tea retain more polyphenols in their intact form, as oolong and black teas undergo more extensive processing before they are marketed. Tea polyphenols break down in high temperatures therefore; freshly brewed tea contains a higher amount of polyphenols per serving than do tea drinks that are canned or bottled.
Similar to the blueberry, the black chokeberry is high in anthocyanins and antioxidant activity. It is native to eastern North America and has become popular in Eastern Europe and Russia due to its health-promoting potential. This berry protects the liver from chemical poisoning and the stomach lining from ulcers. It also acts as an anti-inflammatory, lowers harmful cholesterol levels, and prevents dangerous swings in blood pressure. Some studies have shown that this berry seems to prevent the harmful mutations in cell cultures, regulates immune function of human white blood cell cultures, and SUPPRESSED the growth of human colon cancers.
Flax Seed Oil
August 07, 2008 01:53 PM
Flax seed naturally contains a variety of different categories of essential fatty acids, which includes alpha linoleic acid, linoleic acid, and omega-9 oleic acid. A lot of flax seed’s benefits are a function of its content of alpha linoleic acid, which is converted in the body to a longer chain of omega-3 EPA. Research has proven that supplementation with flax seed oil can help to increase the EPA concentrations in many tissues of the body. One of the main areas of research has been inflammation.
Many factors contribute to inflammatory reactions, including omega-6 linoleic acid, which can be converted into pro-inflammatory substances. Flax alpha linoleic acid can convert into EPA, which has the ability to convert into a prostaglandin that has anti-inflammatory properties. In inflammatory states, alpha linoleic acid and EPA compete with linoleic acid for enzymatic metabolism, resulting in a decreased production of pro-inflammatory substances. Many studies have found that the use of flax seed oil in domestic food preparation can reduce the production of inflammatory cytokines.
These studies have also shown the ability of omega-3 rich fish oils to inhibit inflammatory mechanisms in the autoimmune disease lupus nephritis, which lead to the investigation into flax having any abilities in this area. One trial found that 30g/d of flax seed was optimal for improving kidney function, decreasing inflammation, and reducing atherosclerotic development. Flax also contains antioxidants, which may be helpful to those who have SLE.
Research has also been conducted to investigate the hormonal modulating effects of ingesting lignans, which are antioxidant and phyto-estrogenic compounds that are found in flax seed. Clinical evidence indicates that phytoestrogens have an anti-cancer effect on the breast. Experimental studies in animals and humans have also demonstrated flax’s anti-cancer effects, with a 1998 review indicating that the consumption of flax may be used as a secondary prevention method against breast cancer. Flax seed has also been shown to promote prostate health, as it plays a key role in the treatment of an enlarged prostate.
The cardiovascular system is also another area of research focus for flax seed. One study showed that three months of flax seed supplementation resulted in LDL cholesterol levels dropping significantly, while HDL cholesterol did not change. Other research has shown serum lipid level reduction, but a large amount of flax seed was required to be consumed to get the same lipid-lowering effects as fish oils. Flax lignans also possess anti-platelet activating factor activity and antioxidant activity. Animal research has shown that flax seed reduced the development of aortic atherosclerosis’ by 46 percent and SUPPRESSED oxygen-free radicals.
The research concluded that dietary flax seed supplementation could prevent hypercholesterolemia-related heart attack and strokes. Lastly, the elasticity of arteries is an important factor of circulatory function, which decreases as the cardiovascular risk increases. Research has proven that obese people consuming a diet high in ALA from flax seed oil experience a marked rise in arterial elasticity, which reflects a rapid improvement in the arterial circulation.
Although flax seed offers many potential benefits, ingesting the right form of supplemental flax is crucial to gaining these benefits. Flax oil supplements are a good source of EFAs, but they do not provide great amounts of lignans. On the other hand, whole or ground flax seed is effective, but is not especially palatable. The best option of flax seed is the liquid in capsule form, as it delivers both EFAs and lignans. The nutritional value and certain beneficial results can be gained by consuming about 3,000 mg daily.
How Important Is It To Have Proper Digestion
July 09, 2008 11:46 AM
The part played by food in the health of your body is to furnish it with the nutrients needed for the biochemistry that keeps you alive. The digestive process breaks the food that you eat down into a form that can be absorbed by your bloodstream, and from there to your liver which is your body’s chemical plant. That is where most of the biochemical reactions of your body take place, such as the manufacture of bile needed to break down fats during digestion.
Most people do not take this into account when eating, and in today’s hectic world nourishment is the last thing on their minds, yet the one aspect of their lives that can provide them with the energy to carry on as they do. They eat to get rid of the feeling of hunger, and any old thing will do: a burger or a pizza, but rarely an orange or some cheese on wholegrain bread.
Poor eating habits lead to poor digestion, which in turn leads to poor extraction of the nutrients from what we do eat, and therefore malnutrition. Yes, malnutrition! It is possible to suffer from that even though you fill your belly every day. It’s not the filling that matters, it’s what does the filling and how well it is digested. Proper digestion is very important to every living creature on this planet. The first step in ensuring that have a proper digestion function is to assess the quality of the food that you eat:
a) What nutrients does your food contain, and
b) Have you sufficient of the proper enzymes needed to break it down so that these nutrients can be extracted?
Nourishing meals are just as easy to find and eat as junk foods, and it is just as easy to a breakfast containing a high protein and fat content as it is to eat a chocolate biscuit. A hard boiled egg with whole meal toast and yoghurt isn’t difficult to prepare for breakfast, and some tuna, or cheese and whole meal crackers make a nutritious lunch. These foods are easier to digest than the greasy high-fat foods that most people eat at lunchtime.
Proper digestion requires relaxation, and eating when stressed or in a hurry creates the wrong pH conditions in your stomach, with hydrochloric acid production being SUPPRESSED and the production enzymes by the liver inhibited. Enzymes are essential to your health, and are types of protein that enable most biochemical reactions to take place. Without the proper production of enzymes, your food will pass through your body largely unchanged, and this indigestion can not only give you stomach pains but also weaken you because the nutritional value of your food is not being realized.
You should take the time to eat, and not try to eat on the job: that is why so many high fliers end up with ulcers. Take time to chew, and mix your food with saliva which itself contains the enzymes amylase and lysozyme. Amylase breaks down starch into sugars, while lysozyme inhibits the growth of oral bacteria. The digestive system therefore begins in the mouth when you chew your food. The breakdown of food into smaller particles also produces more surface area from which the nutrients can be absorbed.
Enzymes are very important to proper digestion, and your diet should include enzyme-rich food such as tropical fruits (pineapple and bananas), honey, and many vegetables. Yoghurt and lacto-fermented foods are also rich in enzymes, and many cooked foods also contain enzymes. An enzyme supplement can also be taken to top-up what you eat, and make up for any enzyme deficiency in your diet. Processed foods are fairly empty of good nutritional value, particularly enzymes, which is why so many people are so overweight: their food is a nutritional desert and their body keeps craving for food that leads to eating binges.
For your food to be properly digested your stomach acid has to be at a certain pH. If you drink too much liquid when eating then the acid will be diluted, and you will not properly digest your food. A glass of water is fine but two or three pints of beer, or a gallon of fruit juice, will dilute the hydrochloric acid concentration in your stomach, and it will not be able to break down your food. Consequently, your digestive system loses much of the nutritional content of what you eat. Restrict heavy drinking of liquid to about two hours before and two hours after eating each meal for maximum efficiency. Many people find that they have to take not only vitamin and mineral supplements to replace those which are lost through inefficient digestion, but also other supplements such as enzymes and extra proteins.
When food is processed or cooked, the process destroys enzymes. Since the body stores only a limited supply of enzymes, eating well cooked or highly processed foods continuously, places great strains on the enzyme reserves, and ultimately the metabolic enzyme reserves have to be used in order to digest your food. This diverts them from their proper purpose, and many of the functions of your body are disrupted.
For example, your lose energy and your immune systems begins to weaken, making you feel tired and more susceptible to illness and disease. You should therefore try to eat foods rich in enzymes, or use an enzyme supplement. Natural raw foods are an excellent addition to your diet, and salads and fruit should be regular components of your meals. Obviously you must eat some cooked foods, but that does not mean that you should avoid eating fresh raw fruits and vegetables altogether. That is a recipe for a dietary disaster.
Enzymes are extremely important components of your digestive system, as is dietary fiber. In fact if you eat a diet containing dietary fiber, some raw fruit and vegetables, and protein, either cooked or uncooked, you will be giving your digestive system a boost. If you are unable to maintain that, then enzyme supplementation, together with general multi-vitamin and mineral supplement daily, should help you to maintain a healthy digestive system. However, fiber is essential since without it you will become constipated, especially if you consume a lot of pulpy foods that mainly consist of water.
It is extremely important that you have proper digestion of the food that you eat, and that your body makes the best use of the nutrients that it contains. To achieve this, you have to maintain the correct pH of stomach acid, and eat foods with the nutritional content required by the human body. This means not overcooking a balanced diet containing protein, fiber, enzymes and other nutrients such as vitamins, minerals and phytochemicals (plant-based chemicals).
April 29, 2008 10:49 AM
Butterbur extract is taken mainly from the rhizome, root and leaves of the butterbur, a member of the daisy family. They are very hardy and have creeping underground rhizomes and large leaves like those of rhubarb. Another name given to it is the sweet Coltsfoot, and they generally grow in the temperate climates of Europe, North Africa and South west Asia. They like damp conditions, specifically marshes and ditches, and also riverbanks where there are always plentiful supplies of moisture.
It has been used by Native Americans for headaches and inflammation, and has been shown to be an effective remedy for hay fever and to provide relief from painful menstrual cramps. Butterbur has also been used throughout the middle Ages to treat fever and the plague, and has been recorded in the seventeenth century as being used for asthma, wounds and coughs. However, one of its most important applications is in restore bladder function in the incontinent and semi-incontinent.
Urinary incontinence is typified by an unusually high frequency of urination – more than 8 times a day, an immediate strong urge to pass water or leaking and involuntary urination. Any two of these three indicates urinary incontinence. As people age their bladders become smaller, and by definition the periods between urination will reduce. This does not, however, suggest that bladder size is the cause of urinary incontinence.
Urination is caused by the contraction of the smooth layered muscle that surrounds the bladder, called the detrusor, a contraction in turn caused by neurons both in the brain and in the detrusor itself. This naturally contracts and expands according to the volume of urine in the bladder, and once the bladder is about half full the brain will tell you that the detrusor is ready to contract to expel the urine. However, if the time is not convenient, the cortex will suppress this desire until a more convenient time.
In incontinence, the desire is SUPPRESSED but the neurons still fire to contract the detrusor, expelling urine at inconvenient moments. Butterbur contains the sesquiterpenes petasin and isopetasin, which are known to reduce spasms in smooth muscle tissue and in vascular walls. It can therefore be used to control the involuntary spasms that cause urine leakage or expulsion against the patient’s wishes. These sesquiterpenes are at highest concentration in the roots of the plant.
The effect that the sesquiterpenes have in inhibiting the synthesis of leukotriene in leukocytes tends to support this effect, since leukotrienes can cause contraction of vascular and smooth muscle tissue. Not only this, but the spasmolytic effect could also be explained by the inhibition of cellular calcium caused by the petasin isomers.
Many studies have indicated that the effectiveness of butterbur extract is also useful in the prevention of migraines. There has been a lot of research carried out on the use of butterbur extract on migraine sufferers, and the effective dose appears to about 75 mg twice daily. There is little evidence of it being a cure but as a prophylactic there appears no doubt of its efficacy: there have been too many positive results against placebos for its effect to be deniable.
It is significant that leukotriene can cause constriction of the small blood vessels in the veins, and so affect the flow of blood. Butterbur, in inhibiting its biochemical production, helps to keep these blood vessels open. Lekotrienes are also important components of inflammation, and altogether it appears that whatever the real cause of migraine, the petasin isomers in butterbur have an effect in inhibiting its initiation. Add to that the potential reduction in calcium content that can cause blood vessels to become less flexible, and the argument for its effectiveness is both irrefutable and well explained.
In one example of such a double blind study that is representative of many, a group of patients given 50 mg butterbur extract twice a day for twelve weeks experienced a 60% reduction in the frequency of attacks, a reduction in the severity of the attacks they did have, and a reduction in the length of the attacks. Although the vascular theory of the cause of migraine is no longer supported, maintenance of the vascular system appears to at least reduce the likelihood of attacks.
The effect of butterbur on asthma and other allergic reactions is also well documented. This again is due to its anti-spasmodic properties and inhibitory effect on the inflammatory immune response through the inhibition of leukotriene synthesis and the consequent positive effect on the metabolism of prostaglandin. Prostaglandins also constrict vascular smooth muscle cells, regulate the mediation of the inflammatory response and constrict general smooth muscle cells. All of these can lead a to a variety of disorders cause by smooth muscle spasms in additional to urinary incontinence, such as menstrual cramps, liver and gastrointestinal disorders and asthmatic conditions.
In one study of allergic rhinitis, administration of butterbur extract appeared to result in a reduction in the histamine and leukotriene content of nasal fluids and no difference was noticed between this treatment and histamine treatment. This was a useful study because histamines causes drowsiness and butterbur can be used as a substitute for histamine without the sedative effect. A study in Germany in 1993 has shown that the stomach ulceration caused by the anti-inflammatory medications for arthritis was reduced by the administration of butterbur extract
Cetirizine is a commonly prescribed prescription treatment for allergic conditions, and studies comparing that with butterbur demonstrated them to be equally effecting in reducing the symptoms typical of allergic reactions such as sneezing, runny nose and nasal congestion. 50% of the patients in the group took each and there was no difference in results. Again it was explained by the petasin limiting the production of leukotriene and histamine, both of which are produced by the immune response and promote mucous secretions and inflammation. They also constrict airways that can be serious to asthma sufferers
These studies are simply providing scientific evidence and explanations for the tradition use of this plant for such conditions. Butterbur has been used for centuries to treat such conditions all over Western Europe, and once again the use of traditional medicine has been supported by modern investigative techniques.
Chronic Fatigue Syndrome and Fibromyalgia
February 28, 2007 12:02 PM
This is a fast paced world. We are all busy; living our full lives, burning the candle at both ends. We all get tired. We all get sick from time to time and maybe even depressed. But the illness called chronic fatigue syndrome is not like the normal ups and downs that we experience in everyday life. People with chronic fatigue syndrome feel overwhelming fatigue, and often pain as well. This is an illness that does not go away with a few good nights’ sleep. It drags on and on and doesn’t resolve itself. It steals vigor and energy over months, and sometimes even years.
In this issue of Ask the Doctor, we will talk about powerful vitamins, minerals, amino acids, and herbs combined in scientifically validated formulas that people with chronic fatigue syndrome or fibromyalgia can use every day. These nutrients help address some root problems of chronic fatigue syndrome and fibromyalgia by restoring energy and health to sufferers.
Q. What is chronic fatigue syndrome?
A. Chronic fatigue syndrome (CFS) also known as chronic fatigue and immune dysfunction syndrome (CFIDS), or myalgic encephalomyelitis (ME), is a group of symptoms associated with unrelenting and debilitating fatigue. The profound weakness of CFS causes a persistent and substantial reduction in activity level. You feel too tired to do normal activities or are easily exhausted for no apparent reason.
Besides extreme fatigue, symptoms of CFS include general pain, mental fogginess, flu-like symptoms, and gastrointestinal problems. A list of symptoms includes:
The number of symptoms and the severity of these symptoms can vary among people. The symptoms of CFS hand on or reoccur frequently for more than six months.
Q. Are chronic fatigue syndrome and fibromyalgia considered being the same illness?
A. Fibromyalgia syndrome (FMS) is a painful shortening of muscles throughout the body. FMS is basically a sleep disorder characterized by many tender knots in the muscles. These tender knots, called tender or trigger points, are a major cause of the achiness that people with fibromyalgia and CFS feel.
Approximately 80 percent of chronic fatigue syndrome patients have received and overlapping diagnosis of fibromyalgia syndrome. For most people, fibromyalgia and chronic fatigue syndrome are the same illness.
Q. What causes chronic fatigue syndrome?
A. There are many causes that can trigger CFS. Current research is looking at the roles of neuroendocrine dysfunction, viruses, environmental toxins, genetic predisposition, food sensitivities, yeast overgrowth, faulty digestion, or a combination of these factors.
For many people, CFS is triggered by a bout with a viral illness (like a cold or the flu), or even a stressful event. CFS is usually a mix of underlying causes. It is like a domino effect in that each problem can trigger another problem, and so on. For example, fatigue and poor sleep can trigger a weakened immune system, which can, in turn, trigger yeast or bacterial infections.
Q. Who gets chronic fatigue syndrome?
A. CFS is more common than you might expect. It strikes people of all ages, racial, ethnic, and socioeconomic groups. Approximately 800,000 people nationwide have CFS and over six million have fibromyalgia at any given time.
It is important to stress that CFS is a real illness; it is not “just in your head.” Unfortunately, sufferers of CFS may find that many healthcare practitioners discount the symptoms of this illness or misdiagnose it as another disease. This can lead to additional emotional suffering.
Q. How long does chronic fatigue syndrome last?
A. The illness varies greatly in its duration. Some people recover after a year or two. More often, those who recover are more likely to do so three to five years after onset. Yet for some people, the illness seems to simply persist. There are rare cases of spontaneous improvement after five years without undergoing any treatment. However, this is very unusual.
Q. What are the complications of chronic fatigue syndrome?
A. The patterns of CFS vary from individual to individual. However, many common patterns of symptoms are seen in CFS sufferers. These symptoms and problems interact and create new symptoms and problems. For example, infections and disrupted sleep can lead to digestive, hormone, and immune problems.
The most notorious pattern seen in CFS is the one in which a person suddenly comes down with a flu-like illness that doesn’t go away. These viral or bacterial infections can suppress the body’s master gland, the hypothalamus. Since the hypothalamus controls the other glands, including the adrenals, ovaries, testes, and thyroid, suppression of this gland will lead to a subtle but debilitating decrease in the functioning of all glands and their hormones. SUPPRESSED hypothalamic function from chronic infections can then trigger sleep dysfunction.
The suppression of the hypothalamus gland can lead to poor sleep because the body confuses its day/night cycles. Because of this, people with CFS have trouble staying in the deep, restorative stages of sleep that “recharge their batteries.”
Poor sleep can cause immune suppression, which may lead to secondary bowel infections. The bowel infections seen in people with CFS can cause decreased absorption of nutrients, which can lead to chronic vitamin and mineral deficiencies.
Q. Is there a cure for chronic fatigue syndrome?
A. Treating chronic fatigue syndrome presents a significant challenge to people with CFS and their healthcare practitioners. Recently, a published placebo-controlled study ( of which I was the lead investigator) showed that when using an integrated treatment approach, over 85 percent of CFS and fibromyalgia patients can improve, often dramatically. The full text of this study can be seen at ‘www.endfatigue.com’. An editorial in the April 2002 issue of the Journal of the American Academy of Pain Management noted that this treatment, which I developed, is now a highly effective and excellent part of the standard of practice for treatment of fibromyalgia. Since this treatment addresses many different problems associated with CFS/FMS, it needs to be individualized to each patient.
Medications that provide symptom relief are frequently the first line of treatment chosen by healthcare practitioners for the person with CFS. These include medications for pain, sleep disturbances; digestive problems such as nausea, depression and anxiety, and flu-like symptoms.
However, medications have not been universally successful because they tent to put a bandage on symptoms instead of addressing the root problems. Because of this, medications may need to be supplemented by the other supportive therapies that can address the root problems.
People with CFS/FMS may be depressed, given the catastrophic lifestyle disruption these diseases may cause. They may also feel guilt and frustration because their symptoms were not taken seriously for such a long time. Fear can be a factor as employment and family relationships may be jeopardized by this illness.
Therapies that help people to relax and improve coping skills may be helpful and include counseling for emotional and mental health, cognitive behavioral therapy, sleep management therapy, and massage.
Daily Nutritional Supplementation for Energy
Good overall nutrition is important for everyone, of course. However, there are several vitamins, minerals, and amino acids that can have powerful nutritional effects for a person with CFS. All of the vitamins and minerals in a chronic fatigue/fibromyalgia formula should work together synergistically to help improve energy levels and overall health. Here are some key nutrients to look for in an energy formula:
Vitamins, Minerals & Other Key Ingredients
Vitamin A: Essential for healthy skin and mucous membrane integrity, healthy immune system responses and healthy bone growth and healthy reproductive processes. Vitamin A in the form of beta-carotene is an antioxidant and free radical fighter. Vitamin E: Helps to relieve pain in CFS patients. Can also improve night leg cramps, which interferes with sleep.
Vitamin C: Enhances immune function by increasing natural killer cells, B and T cells. Can prevent chronic bladder infections by acidifying urine.
Vitamin D: Regulates immune functions of monocytes and neutrophils. Neutraphils are white blood cells that ingest invasive bacteria, and act as the first line of defense once bacteria makes it past the skin barrier.
Magnesium: Involved with immune support. Working with malic acid, enhances immune function by increasing natural killer cells. Magnesium is also critical for the relief of muscle pain.
Inositol: Enhances immune function by increasing natural killer cells.
Malic Acid: Working with magnesium, improves energy levels by improving cellular functions. Especially important in muscle metabolism.
Betaine: Works with B vitamins to synthesize amino acids, and acts as a precursor to SAM-e. SAM-e (S-adenosylmethionine) is a naturally-occurring molecule in the body, and may have an effect on overall mood elevation.
Amino Acids: Glycine, Serine, Taurine, Tyrosine are essential for the production of energy in the body. Also essential for brain function.
Zinc: Supports the immune system by enhancing neutrophils activity and supporting healthy antigen-antibody binding.
Selenium: Supports immune function by enhancing antibody production.
Fructooligosaccharides: Provides nutrition for good bacteria in the intestinal tract, improving digestion and healthy microflora.
All of the vitamins, minerals, and other nutritional supplements on the list are important to ensure recovery from chronic fatigue syndrome. To ensure that your nutritional supplement regimen contains all of these ingredients, look for a powdered supplement formulated specifically for CFS/FMS sufferers that can be reconstituted in a beverage of your choice. A powdered drink mix is a pleasant, easy way to ensure that you are taking all of the needed vitamins, minerals, and amino acids that will give you the needed energy to recover from your illness.
B Vitamin Complex for Energy
In addition to the powdered energy drink mix, it is important that you also take a vitamin B-complex supplement specifically formulated for people with CFS/FMS. The B vitamin formula, which should include niacinamide, thiamin, riboflavin, vitamin B6, folic acid, vitamin B12, pantothenic acid, and choline, is especially important to restore the energy production needs of your body, as well as for mental function. It is also important to make sure that the dosages are high enough CFS/FMS needs. The chart in the next column lists the B vitamins that are critical for people suffering from CFS/FMS.
B Vitamins Effect on Chronic Fatigue Syndrome
Studies have demonstrated that people with CFS/FMS are often deficient in many of the B vitamins, which tends to worsen their symptoms of fatigue and mental “fogginess” and ultimately lead to a weakened immune system.
B vitamins - Effect on Energy
Thiamine (B1) - Essential in the process of energy production. This vitamin also removes lactic acid from muscles, which causes them to be sore in fibromyalgia patients.
Riboflavin (B2) - Riboflavin (vitamin B2) is crucial in the production of body energy. Supports healthy gluthathione reductase activity, which helps maintain gluthathione, a major protector against free radical damage. Vitamin B2 itself also has antioxidant qualities.
Niacinamide(B3) - Essential vitamin that is a component of the body’s energy furnace, helping to improve fatigue and “brain fog”.
Pantothenic Acid (B5) - This vitamin improves adrenal gland function, which will boost energy levels. It can also aid in weight loss by decreasing appetite.
Vitamin B6 - Working along with thiamine, this vitamin is critical in the process of energy production.
Vitamin B12 - Important for brain function and nerve repair. Aids in relieving fatigue symptoms in CFS patients. Folic Acid - Aids in strengthening the immune system, and aids in mental clarity and concentration.
Q. What other supplements can help me with CFS?
A. Many people with CFS/FMS are suffering from adrenal burnout. Adrenal burnout occurs when the adrenal glands are constantly producing cortisol in response to chronic stress like that seen in cases of CFS. Over time, this exhausts the adrenal reserve, meaning the adrenal gland can no longer increase cortisol production in response to stress.
The good news is that changes in our hormone levels can return to normal when stress is decreased. However, in cases of CFS that return to normal can be made much simpler by using a glandular therapy regimen to ensure healthy cortisol levels and adrenal function.
Glandular therapy uses the concentrated forms of bovine (cow) or porcine (pig) glands to improve the health of our glands. Pioneers in the field of endocrinology (the study of hormones) hypothesized that glandular extracts work by providing nutrients the body lacks and thus repairing the malfunctioning gland.
If CFS has left your adrenal glands in a stressed-out state, you should see great results by taking adrenal supplements. Be sure to buy an adrenal extract supplement that contains both whole adrenal and adrenal cortex extracts.
The best adrenal supplement should also contain vitamin C, vitamin B6, L-tyrosine, betaine, pantothenic acid and licorice. Licorice contains glycyrrhizin, which is broken down into glycyrrhizic or glycyrrhetinic acid. This compound inhibits the activity of an enzyme that turns active cortisol into inactive cortisol. While in high amounts (greater than 100 mg of glycyrrhizic acid/day), licorice administration causes hypertension, no such effects have been observed at lower doses. Experts have speculated that inhibition of the cortisol-converting enzyme may reduce cortisol-related symptoms associated with adrenal insufficiency. The adrenal glands use these nutrients to manufacture cortisone and other compounds. It just makes sense to purchase an adrenal supplement with these supportive ingredients.
The Road to Recovery-Adequate Sleep
Disordered sleep is the underlying process that drives many of the symptoms of CFS/FMS. The most effective way to eliminate pain in CFS/FMS is to get seven to nine hours of deep sleep each night.
However, getting adequate sleep is easier said than done for CFS sufferers with underlying fibromyalgia symptoms. The muscle knots of fibromyalgia make it uncomfortable to lie in one position for an extended time, causing difficulty in returning to deep sleep. Because of this, people with CFS/FMS do not stay in deep stages of sleep to recharge their “batteries.” In addition, poor sleep can cause and be caused by the suppression of the hypothalamus gland, which causes the brain to think it is daytime instead of night time.
It may be helpful to use herbal products to promote good quality sleep. There are many natural supplements that are marketed as sleep formulas. To get the best results, it is very important that the right ingredients are in the sleep formula you buy. Therefore, it is important to look for an herbal sleep formula that is especially formulated for people with CFS/FMS. The combination of herbs is important as each herb addresses a different aspect of sleeplessness and muscle tension.
Ingredients - Effect on Sleep
Wild Lettuce - Has been found to have sedative effects.
Hops - Acts as mild sedative and has a sleep-inducing effect. Jamaica Dogwood Has been found to be mildly sedative and is often used for anxiousness.
L-Theanine - Causes significant increases of neurotransimitter concentrations in the brain, which promotes muscle relaxion and improves sleep.
Valerian - This herb has been clinically studied for its ability to improve sleep quality.
Passionflower - This herb eases nervousness and insomnia.
Putting It All Together
After a good night’s rest, a powdered energy drink mix formulated for people with CFS/FMS should be drunk along with a well-balanced breakfast as discussed earlier. In addition to the nutritional beverage mix, a vitamin B complex supplement designed specifically for CFS sufferers, also discussed earlier, containing niacinamide, thiamin, riboflavin, vitamin B6, vitamin B12, pantothenic acid, and choline, should be taken every morning. The nutritional drink mix and the vitamin B complex supplement will ensure that your body has all the vitamins, minerals, amino acids, and other nutrients, to combat your overwhelming fatigue, pain, and “brain fog.” Taking a daily adrenal supplement, like the one discussed earlier, will provide the much-needed (and often depleted) nutrients your body may be lacking, and help you recover lost energy.
Together, these four interventions: sleep formula; morning energy drink; energy B complex supplement; and an adrenal complex- can make an incredible difference that you should begin to notice within 2-3 weeks of starting this program.
Chronic fatigue syndrome and fibromyalgia are complex physical diseases with physical causes. The unrelenting symptoms of fatigue, pain, and mental fogginess can be overwhelming and frightening. Partnering with a healthcare practitioner specializing in CFS and utilizing different medical treatments, supportive therapies, and lifestyle changes are healthy ways to combat chronic fatigue syndrome. And taking nutritional supplements formulated specifically for people with CMS/FMS that help boost energy or help you get a good night’s sleep can give you critical control over the outcome of your illness and set you on the road to recovery.
Vitamin B-1, C prove Worthy Complementary Therapies
March 31, 2006 06:30 PM
An increasing number of healthcare experts are calling for conventional and alternative treatments to be used together, an idea supported by a growing body of research. For example, British scientists found that taking one gram of supplemental vitamin C a day for 10 weeks helped 92 adults with asthma reduce the medication they needed for symptom control (respiratory Medicine 2006; 100:174-9). Inhaled asthma drugs have been associated with severe side effects, such as bone loss, cataracts and SUPPRESSED immunity. Increasing Vitamin Intake (in this case B-1) may also prove vital to people undergoing gastric bypass surgery, an increasingly common option for obesity. The December 27, 2005 issue of Neurology reported on a 35-year-old woman who suffered numerous difficulties after gastric bypass, including fatigue, confusion and an inability to coordinate eye movement. Her condition improved after she received 100mg of intravenous B-1 every eight hours.
Other supplement news:
Substance abuse –and the problems it causes-may be amenable to supplementation. At a meeting of American College of Neuropsychopharmacology (12/5), researchers claimed that hospitalized cocaine addicts experienced reduced desire for the drug after taking the supplement NAC (N-acetylcysteine); they said more study is needed. In another investigation presented at the same meeting, fish oil helped reduce anger among male substance abusers, possibly reducing the risk of aggressive behavior.
What are the complications of chronic fatigue syndrome?
December 10, 2005 03:14 PM
A. The patterns of CFS vary from individual to individual. However, many common patterns of symptoms are seen in CFS suffers. These symptoms and problems interact and create new symptoms and problems. For example, infections and disrupted sleep can lead to digestive, hormone, and immune problems.
The most notorious pattern seen in CFS is the one in which a person suddenly comes down with a flu-like illness that doesn’t go away. These viral or bacterial infections can suppress the body’s master gland, the hypothalamus. Since the hypothalamus controls the other glands, including the adrenals, ovaries, testes, and thyroid, suppression of this gland will lead to a subtle but debilitating decrease in the functioning of all glands and their hormones. SUPPRESSED hypothalamic function from chronic infections can then trigger sleep dysfunction.
The suppression of the hypothalamus gland can lead to poor sleep because the body confuses its day/night cycles. Because of this, people with CFS have trouble staying in the deep, restorative stages of sleep that “recharge their batteries.”
Poor sleep can cause immune suppression, which may lead to secondary bowel infections. The bowel infections seen in people with CFS can cause decreased absorption of nutrients, which can lead to chronic vitamin and mineral deficiencies.
July 15, 2005 12:15 PM
While aspartame and saccharine continue to dominate the non-caloric sweetener scene, a remarkable herb called stevia remains relatively obscure. Why would a substance that is much sweeter than sugar, can be used in baking (unlike aspartame), is diabetic-safe and calorie- free remain unknown and unused? Unfortunately, the FDA has managed to unfairly keep stevia out of the American market due to a long history of unwarranted regulation. Recently, however, due to the passage of specific legislation, limited purchase of stevia products is now available.
Anyone who suffers from blood sugar disorders or who needs to limit their caloric intake should know about the remarkable properties of stevia. Stevia offers an ideal alternative to other sugars or sugar substitutes. Moreover, the herb has numerous therapeutic properties and has proven its safety and efficacy for hundreds of years. In spite of FDA efforts to ban this herbal sweetener, stevia’s comeback has begun amidst a glut of approved artificial, pharmaceutical products that pose significant health risks. The story of stevia illustrates the struggle which many natural products have experienced in gaining the FDA stamp of approval. Patents, politics and profits are all involved in determining the selection of products we are allowed to purchase. The history of stevia’s use in this country epitomizes the sad fact that effective natural supplements are often SUPPRESSED, while much riskier artificial chemicals are praised and aggressively marketed.
Pain - Post Op and Relaxation
July 13, 2005 09:24 AM
Relaxation, Music Reduce Post-Op Pain. New research has found that relaxation and music, separately or together, significantly reduce patients' pain following major abdominal surgery. The study, published in the May issue of the journal Pain, found that these methods reduce pain more than pain medication alone. Led by Marion Good, PhD, RN, of Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, the study is supported by the National Institute of Nursing Research (NINR), at the National Institutes of Health. "This is important news for the millions of Americans who undergo surgery and experience postoperative pain each year," said Dr. Patricia A. Grady, director of the NINR.
"Better pain management can reduce hospital stays and speed recovery, ultimately improving patients' quality of life." Dr. Good and her research team studied three groups of patients undergoing abdominal surgery. In addition to the usual pain medication, one group used a jaw relaxation technique, another group listened to music, and a third group received a combination of relaxation and music.
Findings revealed that, after surgery, the three treatment groups had significantly less pain than the control group, which received only pain medication. "Both medication and self-care methods which involve patient participation are needed for relief," said Dr. Good.
"These relaxation and music self-care methods provide more complete relief without the undesired side effects of some pain medications." The findings have important implications for the 23 million people who undergo surgery and experience postoperative pain annually in the United States. Pain can hamper recovery by heightening the body's response to the stress of surgery and increasing tissue breakdown, coagulation and fluid retention. Pain also interferes with appetite and sleep and can lead to complications that prolong hospitalization.
Dr. Good and her research staff worked with 500 patients aged 18-70, who were undergoing gynecological, gastrointestinal, exploratory or urinary surgery. Prior to surgery, those in the music, relaxation or combination groups practiced the techniques. The relaxation technique consisted of letting the lower jaw drop slightly, softening the lips, resting the tongue in the bottom of the mouth, and breathing slowly and rhythmically with a three-rhythm pattern of inhale, exhale and rest. Patients in the music group chose one of five kinds of soothing music--harp, piano, synthesizer, orchestral or slow jazz.
On the first and second days after surgery, all patients received morphine or Demerol for pain relief by pressing a button connected to their intravenous patient controlled analgesia pumps. The groups receiving the additional intervention used earphones to listen to music and relaxation tapes during walking and rest, while the control group did not. The research team measured the patients' pain before and after 15 minutes of bed rest and four times during walking to see if the sensation and distress of pain changed.
Dr. Good found that during these two days postsurgery the three treatment groups had significantly less pain than the control group during both walking and rest. "Patients can take more control of their postoperative pain using these self-care methods," says Dr. Good. "Nurses and physicians preparing patients for surgery and caring for them afterwards should encourage patients to use relaxation and music to enhance the effectiveness of pain medication and hasten recovery."
Dr. Good's findings have implications for future research into the effectiveness of self-care methods on other types of pain, including chronic pain, cancer pain, and pain of the critically ill.
Vitamin D Lack Linked to Hip Fracture. Vitamin D deficiency in post-menopausal women is associated with increased risk of hip fracture, according to investigators at Brigham and Women's Hospital in Boston, Mass. In a group of women with osteoporosis hospitalized for hip fracture, 50 percent were found to have a previously undetected vitamin D deficiency. In the control group, women who had not suffered a hip fracture but who were hospitalized for an elective hip replacement, only a very small percentage had vitamin D deficiency, although one-fourth of those women also had osteoporosis. These findings were reported in the April 28, 1999, issue of the Journal of the American Medical Association.
The study, conducted by Meryl S. LeBoff, MD; Lynn Kohlmeier, MD; Shelley Hurwitz, PhD; Jennifer Franklin, BA; John Wright, MD; and Julie Glowacki, PhD; of the Endocrine Hypertension Division, Department of Internal Medicine, and Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, was supported by grants from the National Institute on Aging (NIA) and the National Center for Research Resources (NCRR. These investigators studied women admitted to either Brigham and Women's Hospital or the New England Baptist Hospital, both in Boston, between January 1995 and June 1998.
A group of 98 postmenopausal women who normally reside in their own homes were chosen for the study. Women with bone deterioration from other causes were excluded from the study.
There were 30 women with hip fractures caused by osteoporosis and 68 hospitalized for elective joint replacement. Of these 68, 17 women also had osteoporosis as determined by the World Health Organization bone density criteria. All the participants answered questions regarding their lifestyle, reproductive history, calcium in their diet, and physical activity.
Bone mineral density of the spine, hip, and total body were measured by dual X-ray absorptiometry (DXA) technique, as was body composition. Blood chemistry and urinary calcium levels were analyzed. The two groups of women with osteoporosis did not differ significantly in either time since menopause or bone density in the spine or hip. They did, however, differ in total bone density.
The women admitted for a hip fracture had fewer hours of exercise than the control group. Fifty percent of the women with hip fractures were deficient in vitamin D, 36.7 percent had elevated parathyroid hormone (PTH) levels (a hormone which can stimulate loss of calcium from bone), and 81.8 percent had calcium in their urine, suggesting inappropriate calcium loss. Blood levels of calcium were lower in the women with hip fractures than in either elective group.
These researchers propose that vitamin D supplementation at the time of fracture may speed up recovery and reduce risk of fracture in the future. Current Dietary Reference Intake Guidelines contain a daily recommendation of 400 IU of vitamin D for people aged 51 through 70 and 600 IU for those over age 70.
"We know that a calcium-rich diet and regular weight-bearing exercise can help prevent osteoporosis. This new research suggests that an adequate intake of vitamin D, which the body uses to help absorb calcium, may help women to reduce their risk of hip fracture, even when osteoporosis is present," observed Dr. Evan C. Hadley, NIA Associate Director for geriatrics research.
"Osteoporosis leads to more than 300,000 hip fractures each year, causing pain, frequent disability, and costly hospitalizations or long-term care. "Prevention of such fractures would greatly improve the quality of life for many older women and men, as well as significantly reduce medical costs." The bones in the body often undergo rebuilding. Some cells, osteoclasts, dissolve older parts of the bones. Then, bone-building cells known as osteoblasts create new bone using calcium and phosphorus.
As people age, if osteoporosis develops, more bone is dissolved than is rebuilt, and the bones weaken and become prone to fracture. Also in many older persons, levels of vitamin D in the blood are low because they eat less or spend less time in the sun, which stimulates the body's own production of vitamin D.
Experts do not understand fully the causes of osteoporosis. However, they do know that lack of estrogen which accompanies menopause, diets low in calcium, and lack of exercise contribute to the problem. Eighty percent of older Americans who face the possibility of pain and debilitation from an osteoporosis-related fracture are women. One out of every two women and one in eight men over the age of 50 will have such a fracture sometime in the future. These fractures usually occur in the hip, wrist, and spine.
Sleep Apnea, Diabetes Link Found. Adults who suffer from obstructive sleep apnea are three times more likely to also have diabetes and more likely to suffer a stroke in the future, according to a new UCLA School of Dentistry/Department of Veterans Affairs study published today in the Journal of Oral and Maxillofacial Surgery. Sleep apnea, a serious condition marked by loud snoring, irregular breathing and interrupted oxygen intake, affects an estimated nine million Americans. The culprit? Carrying too many extra pounds.
"The blame falls squarely on excess weight gain," said Dr. Arthur H. Friedlander, associate professor of oral and maxillofacial surgery at the UCLA School of Dentistry and associate chief of staff at the Veterans Affairs Medical Center in Los Angeles. Surplus weight interferes with insulin's ability to propel sugars from digested food across the cell membrane, robbing the cells of needed carbohydrates. Diabetes results when glucose builds up in the bloodstream and can't be utilized by the body. Being overweight can also lead to obstructive sleep apnea, according to Friedlander.
"When people gain too much weight, fatty deposits build up along the throat and line the breathing passages," he explained. "The muscles in this region slacken during sleep, forcing the airway to narrow and often close altogether." Reclining on one's back magnifies the situation. "When an overweight person lies down and goes to sleep," Friedlander said, "gravity shoves the fat in the neck backwards. This blocks the airway and can bring breathing to a halt."
Friedlander tested the blood sugar of 54 randomly selected male veterans whom doctors had previously diagnosed with obstructive sleep apnea. He discovered that 17 of the 54 patients, or 31 percent, unknowingly suffered from adult-onset diabetes. Using the same sample, Friedlander also took panoramic X-rays of the men's necks and jaws. The X-rays indicated that 12 of the 54 patients, or 22 percent, revealed calcified plaques in the carotid artery leading to the brain.
These plaques block blood flow, significantly increasing patients' risk for stroke. Seven of the 12, or 58 percent, were also diagnosed with diabetes. In dramatic comparison, the 17 patients diagnosed with diabetes showed nearly twice the incidence of blockage. Seven of the 17 men, or 41 percent, had carotid plaques. Only five of the 54 patients who displayed plaques did not have also diabetes. If he conducted this study today, Friedlander notes, he would likely find a higher number of diabetic patients. After he completed the study in 1997, the American Diabetes Association lowered its definition for diabetes from 140 to 126 milligrams of sugar per deciliter of blood.
"This is the first time that science has uncovered a link between sleep apnea and diabetes," said Friedlander. "The data suggest that someone afflicted with both diabetes and sleep apnea is more likely to suffer a stroke in the future." "Persons going to the doctor for a sleep-apnea exam should request that their blood be screened for diabetes, especially if they are overweight," he cautioned. More than half of the individuals who develop diabetes as adults will need to modify their diet and take daily insulin in order to control the disease, he added.
Stress, Surgery May Increase CA Tumors. Stress and surgery may increase the growth of cancerous tumors by suppressing natural killer cell activity, says a Johns Hopkins researcher.
Malignancies and viral infections are in part controlled by the immune system's natural killer (NK) cells, a sub-population of white blood cells that seek out and kill certain tumor and virally infected cells. In a study using animal models, natural killer cell activity was SUPPRESSED by physical stress or surgery, resulting in a significant increase in tumor development.
These findings suggest that protective measures should be considered to prevent metastasis for patients undergoing surgery to remove a cancerous tumor, according to Gayle Page, D.N.Sc., R.N., associate professor and Independence Foundation chair at the Johns Hopkins School of Nursing. "Human studies have already found a connection between the level of NK activity and susceptibility to several different types of cancer," says Page, an author of the study.
"We sought to determine the importance of stress-induced suppression of NK activity and thus learn the effects of stress and surgery on tumor development. "Many patients undergo surgery to remove cancerous tumors that have the potential to spread. If our findings in rats can be generalized to such clinical settings, then these circumstances could increase tumor growth during or shortly after surgery." The research was conducted at Ohio State University College of Nursing and the Department of Psychology at UCLA, where Page held previous positions, and at Tel Aviv University.
Results of the study are published in the March issue of the International Journal of Cancer. In laboratory studies, Page and her colleagues subjected rats to either abdominal surgery or physical stress, and then inoculated them with cancer cells. In the rats that had undergone surgery, the researchers observed a 200 to 500 percent increase in the incidence of lung tumor cells, an early indicator of metastasis, compared with rats that had not received surgery.
The experiment also showed that stress increased lung tumor incidence and significantly increased the mortality in the animals inoculated with cancer cells. "Our results show that, under specific circumstances, resistance to tumor development is compromised by physical stress and surgical intervention," says Page.
"Because surgical procedures are life-saving and cannot be withheld, protective measures should be considered that will prevent suppression of the natural killer cell activity and additional tumor development. "Researchers do not yet know how to prevent surgery-induced immune suppression, but early animal studies have shown increased use of analgesia reduces the risk."
The study was funded by the National Institutes of Health, and the Chief Scientist of the Israeli Ministry of Health. Lead author was Shamgar Ben-Eliyahu, Ph.D., and other authors were Raz Yirmiya, Ph.D., and Guy Shakhar.
The Immune System - with Kyolic Garlic
July 11, 2005 05:23 PM
The immune system is our body's natural defense system that keeps us healthy. Without it, invading organisms, which we come into contact with constantly, would cause illness and disease. There are many components of the immune system, including natural killer cells, T&B cells, macrophages and many others. Collectively, this network mainly functions against bacteria, viruses, fungi, and parasites.
It is possible for the immune system to be SUPPRESSED. Things like stress, unhealthy habits, lack of nutrition, genetics, and other factors damage the immune system, which leaves us vulnerable to disease.
The immune system can benefit from proper, and constant care. A healthy immune system can mean the difference between getting mildly sick versus something much worse. If you are looking for ways to boost your immune system via nutritional supplements, here are a few that might interest you:
Aged Garlic ExtractTM (AGE): Numerous scientific studies have been conducted on AGE in relation to its effect on the immune system. Studies suggest that Aged Garlic Extract may support various immune factors,1-5 such as the ability of immune cells to engulf foreign organisms, T-lymphocyte activity,3 natural killer cell activity1,2 and antibody generation.6 Anti-fungal (Candida albicans-yeast) properties have been shown, and antiviral (herpes1,7, influenza8,9) properties have also been noted. Aged Garlic Extract has also been shown to modify, directly or indirectly, the function of immune cells, which play a leading role in allergic reactions including inflammation.10 In addition, Aged Garlic Extract has been shown to improve age-related deterioration of the immune response.
For your convenience AGE is available as a liquid, and in a capsule, such as the Reserve, FORMULA 100 (tablet or capsule), or as the One Per Day (caplet).
AGE also comes in combination with other herbs and nutrients that may further enhance the immune system. We have formulated a couple of products containing Aged Garlic Extract, specifically for the immune system due to the additional ingredients added that work as an extra boost in this area. Firstly, FORMULA 103 (brown/orange label) in addition to Aged Garlic Extract contains Astragalus, a potent herb demonstrating immune stimulating properties12-17 and vitamin C as Ester-C® (a unique form of Vitamin C) which may support healthy immune function.18 Another product, FORMULA 105 (pink/purple label), contains Vitamins A, C, E, selenium and green tea extract, which are very potent antioxidants. Antioxidants attack free radicals that cause damage to our body, leading to illness and aging. Please keep in mind that the various antioxidant functions attributed to AGE may also help to boost the immune system.
Kyo-Green® is another one of our superb products. Mixing Kyo-Green in a juice or beverage may help to provide extra nutritional support since it is a source of vitamins, minerals, chlorophyll, superoxide dismutase (a very potent anti-oxidant enzyme) and other nutrients. A test tube study by Dr. Lau from Loma Linda University showed that Kyo-Green may provide nutritional support for the immune system by enhancing the activity of macrophages (immune cells that engulf foreign agents).19 Two teaspoons of Kyo-Green also provide the nutrients in a serving of vegetables so this product may function as an easy way to provide extra nutrition for the whole body.
For those who may be interested in a more potent immune boosting formula, please try our Kyo-Green Harvest Blend The Harvest BlendTM contains all of the ingredients in the Kyo-Green, except for the kelp. However, in addition to these ingredients, other active ingredients are added to make forty-four ingredients in total, which may give the immune system a powerful kick. To help support your health there are many different greens, an immune-boosting herbal blend, antioxidant fruits and veggies, immune-enhancing mushrooms, an enzyme active sprout blend, a super energizing blend, special phytonutrients important to immune health, and a nutritious fiber blend. Please read the specifics on each of these constituents, available from the technical information available on this website.
Finally, Kyo-Dophilus® is a probiotic supplement made of a combination of Lactobacillus acidophilus, Bifidobacteria bifidum, and Bifidobacteria longum, which help to maintain a healthy balance of the intestinal microflora and increase our first line of devense in the guy by enhancing macrophages and other immune factors by releasing immune boosting materials. This potent supplement of beneficial bacteria is also ideal for those taking antibiotics, those who are traveling or for those who just want to insure a plethora of beneficial bacteria in their intestinal tracts. Antibiotics are not selective in the bacteria that they kill off. When our friendly bacteria are wiped out, the bad guys have a window of opportunity to take over, as they grow much quicker than our friendly bacteria, and cause us problems. The lactic acid (friendly) bacteria have been shown to produce vitamins, enzymes and antimicrobial compounds that may improve the environment in the intestinal tract. Studies also suggest that friendly bacteria may help to increase resistance to some microbial infections.20-21 Kyo-Dophilus has demonstrated incredible stability at room temperature maintaining more than one billion live cells per capsule through its three-year shelf life. A minimum of one billion live cells per day is considered to be necessary to obtain desired effectiveness from a probiotic supplement. Kyo-Dophilus also comes in tablet form, in a nine-strain formation known as Kyo-Dophilus® 9, and in a smaller form for children, Kid's Kyo-Dophilus®.
Supplying your immune system with adequate nutrition may promote health and ward of illness. If you give the body the tools it needs to heal it-self, it is amazing what it is capable of.
UROVEX: BUTTERBUR EXTRACT Supports healthy urinary urge and frequency Promotes healthy ...
June 29, 2005 02:13 PM
UROVEX: BUTTERBUR EXTRACT Supports healthy urinary urge and frequency Promotes healthy bladder control
Fear—the fear of job loss, embarrassment in social settings, sexual frustrations and psychological stress. That’s what life is like for the nearly 30 million people in the United States who have concerns with bladder control. A burden at any age, bladder issues are highly prevalent in both genders but more common in women. Urinary urge and frequency occurs when the smooth muscle of the bladder contracts without warning. SOURCE NATURALS UROVEX BUTTERBUR is a patented standardized extract that supports healthy urinary urge and frequency. Further, it has been shown to help minimize the sudden urge to urinate, according to a human clinical trial. It has also been shown to support smooth muscle relaxation in animal studies. In vitro studies show that UROVEX BUTTERBUR may reduce bladder cell irritation by inhibiting leukotriene synthesis.
What Goes On
If you experience this circumstance, you probably have two of the following indicators: frequency of urination (usually more than 8 times in 24 hours), urgency (an immediate and strong urge to urinate) and leaking or involuntary loss of urine. Although the changes in urinary anatomy—the result of normal aging—do not cause urinary trouble, they do create a situation that allows this to occur more easily. Aging results in a reduced size of the bladder, producing a decreased bladder volume and a need for more frequent bladder emptying.
Urination involves physiological processes within the urinary tract and the brain. Our brain normally suppresses the urge to urinate until we initiate urination. Neurons in the brain and in smooth muscle of the bladder involuntarily govern the detrusor (layered, smooth muscle that surrounds the bladder) muscle. This muscle contracts and relaxes based on the volume of urine in the bladder and the initiation of urination. The desire to urinate usually starts when the bladder has reached about half its physiologic capacity. This desire is SUPPRESSED by the cerebral cortex until a suitable time and place has been chosen. Butterbur relaxes the detrusor muscle, which reduces pressure on the bladder and thus relieves the urge to urinate. Each capsule contains 50 mg of standardized butterbur, yielding 7.5 mg of the active ingredients petasin and isopetasin. Our extract has been specially processed to remove undesirable pyrrolizidine alkaloids found in some brands.
UROVEX BUTTERBUR EXTRACT has been shown in research to improve the sudden urge to urinate. In one study, 24 women were given butterbur for 8 weeks. After three weeks, 17 women reported a significant reduction of the frequency of urination. Before they began taking butterbur, urination intervals were 30 to 90 minutes, while three weeks later the intervals of 17 of the women were between 90 and 150 minutes. Butterbur is a perennial shrub native to Europe, northern Africa and southwestern Asia that has been used medicinally for centuries to maintain a healthful, active lifestyle. The use of preparations from butterbur has included promoting proper smooth muscle tone, including relief for painful menstrual cramps and other traditional uses.
An All-Natural Solution
Source Naturals is pleased to partner with your natural food product retailer to deliver this botanical treasure that is so effective in solving this often untreated problem. Look for Source Naturals UROVEX BUTTERBUR. It is the only patented butterbur product for bladder control and other traditional uses and is available in 12, 30 and 60 capsule bottles.
INFECTIONS AND GARLIC
June 25, 2005 10:12 AM
INFECTIONS AND GARLIC
With the advent of modern antibiotic drugs, garlic lost its status as an effective infection fighter. Unfortunately, Garlic’s past track record was diminished by the arrival of new and potent antibiotics like penicillin. Ironically, several years ago, garlic was reported to be more valuable than penicillin when treating throat infections.26
One reason for this may be that the allicin component of garlic is effective against the streptococci bacteria. Traditional Oriental medicine utilized garlic in a variety of forms to treat all kinds of infections: garlic juice for typhoid, and meningitis, garlic vapors for whooping cough, garlic suppositories for yeast infections and garlic soup for pneumonia.27 According to studies in the Journal of the National Medical Association, Garlic has proved its ability to act as a potent antibiotic against various gram-negative, gram-positive and acid fast bacteria.
In view of the fact that garlic has even been shown to be effective against some antibiotic-resistent organisms, it should be utilized more in standard medical treatments. Several medical practitioners have discovered that like throat infections, ear infections also respond nicely to garlic. The great advantage of using garlic over antibiotics is that Garlic will not kill friendly intestinal bacteria or make one more susceptible to future infections. Antibiotics will. In cases where antibiotics are deemed necessary, they should at the very least be supplemented with garlic.
Current research supports the fact that garlic does indeed inhibit bacterial growth.28 Several strains of Mycobacterium are SUPPRESSED by the presence of garlic. For anyone who fights chronic bladder infections, garlic may prove invaluable. It has been shown to inhibit the growth of several organisms associated with urinary tract infections.29
Evidence suggests that garlic can effectively treat bacterial ear infections, sore throats, and infected wounds. Several reports have shown that aged garlic extract is particularly effective for the kind of ear infections that children are prone to develop. (Note: Ingesting raw garlic is not a practical way to utilize its allicin compounds as an effective antibiotic. Too much raw garlic would be required to be effective.)
It is common knowledge that as of now, viruses do not respond to antibiotics and are extremely resistent to other forms of treatment. A virus usually has to run its course, as those of us who suffer periodically from colds and flu know all too well. Because viruses are so hardy, it is important to know that garlic possesses antiviral as well as antibacterial properties. Dr. Andrew Weil M.D. states that the best home remedy he has found for the treatment of colds is to eat several cloves of raw garlic at the first indication that a cold is developing.30 Several laboratory tests have shown that garlic is an effectual treatment for both the influenza B virus and herpes simplex virus.31
Two independent researchers in Japan and Romania have found that garlic is able to protect living organisms form the influenza virus.32 Chinese scientists have studies the effect of garlic on viral encephalitis for almost 30 years.
Clarissa McCord of Cloverdale, British Columbia used garlic extract to treat a stubborn virus that attacks horses. She relates:
“A bottle of liquid garlic administered on two successive days to each animal does the job of curing. One of my race hors es developed the virus symptoms and was to be scratched from the racing program scheduled for the following day. I gave one bottle of liquid garlic to the animal and he improved sufficiently to enter the race. He hit the board first, second and third.”33
In relation to human beings, it would seem that Garlic is especially effective in cases of influenza as both a treatment to shorten the duration of the disease and as a preventative. Again, garlic’s ability to stimulate the immune system seems intrinsically linked to its anti-viral action. Whether the infection is bacterial or viral, garlic mobilizes immune function, thereby potentiating the body’s ability to defend itself against infectious organisms.
Garlic in certain forms is considered a potent antibiotic and can be particularly effective against certain fungal infections. Like viruses, fungal infections are particularly difficult to treat . Traditional medical treatments for fungal infections are usually toxic and can be ineffectual over the long term. To the contrary, garlic has proven itself as an effective anti-fungal agent against candida, aspergillus and cryptococci.
A report from a Chinese medical journal delineates the use of intravenous garlic to treat a potentially fatal and rare fungal infection of the brain called cryptococcal meningitis. In the report, the Chinese compared the effectiveness of the garlic with standard medical treatment which involved a very toxic antibiotic called Amphotericin-B. The study revealed that intravenous garlic was more effective than the drug and was not toxic regardless of its dosage.34
One study using liquid garlic extract found that candida colonies were substantially reduced in mice that had been treated with the garlic. This same study also revealed that garlic stimulated phagocytic activity. This implies that infections such as candida may be controlled because garlic stimulates the body’s own defenses. Applied externally, garlic oil can be used to treat ringworm, skin parasites and warts. Lesions that were caused by skin fungi in rabbits and guinea pigs were treated with external applications of garlic extract and began to heal after seven days.35
Allicin is primarily a fungistatic substance which can slow or completely stop the proliferation of the microorganisms. As an external treatment, garlic has also been found to effectively treat acne and thrush.
GARLIC (allium sativum)
June 25, 2005 09:54 AM
GARLIC (allium sativum)
Common Names: Stinking Rose, Poor Man’s Treacle
Plant Parts: bulb
Active Compounds: Garlic contains more than 200 chemical compounds.
Some of its more important ones include: volatile oil with sulphur-containing compounds: (allicin, alliin, and ajoene), and enzymes: (allinase, peroxidase and myrosinase). Allicin is what gives garlic its antibiotic properties and is responsible for its strong odor. Ajoene contributes to the anticoagulant action of garlic. Garlic also contains citral, geraniol, linalool, Aphellandrene and B phellandrene. The allyl contained in garlic is also found in several members of the onion family and is considered a very valuable therapeutic compound.
Pharmacology: The allicins contained in garlic have a fibrinolytic activity which reduces platelet aggregation by inhibiting prostaglandin E2. Allivium sativum has also exerted some effect on glucose tolerance for both hypo-and hyperglycemia by reducing insulin require-ments to control blood sugar. The compounds contained in garlic have also demonstrated their ability to lower total serum cholesterol and triglyceride levels while elevating HDL levels. LDL synthesis is SUPPRESSED by garlic. Garlic allicins have also acted as a larvacide and bacteriostat, active against gram-positive or gram-negative microorganisms. In addition, the compounds can destroy certain fungi such as Candida albicans. Several other microbes are effected by garlic, including some viruses. Most researchers agree that the sulfur containing compounds of garlic, especially allicin, alliin, cy-croalliin, and dialllyldisulphide are the most biochemically active. In addition, certain unidentified substances of garlic will probably emerge as other therapeutic agents.
(Note: Before a bulb of garlic is crushed or chopped, it contains relatively few medically active compounds. Once it is cut, however, chemical reactions take place which create dozens of new compounds.)
Vitamin and Mineral Content: B-vitamins especially B-1, vitamin C, vitamin A, flavonoids, ascorbic acid, phosphorous, potassium, sulphur, selenium, calcium, magnesium, germanium, sodium, iron, manganese and trace iodine. Seventeen amino acids are found in garlic, including eight essential ones.
Character: antibiotic, antihistamine, anticoagulant, expectorant, antibacterial, antiparasitic, alterative, diaphoretic, diuretic , expectorant, stimulant, antispasmodic, promotes sweating, lowers blood sugar and blood cholesterol levels, lowers blood pressure Body Systems Targeted: respiratory, cardiovascular, digestive, and nervous systems
Say Goodbye to Headaches
June 13, 2005 07:25 PM
Say Goodbye to Headaches by Susan Weiner Energy Times, December 8, 1999
What's in a name? A headache by any other name hurts just as much. But categorizing your headache can be as overwhelming as finding an obscure breakfast cereal at the supermarket. Medical folks pigeonhole headaches as tension headaches, allergy headaches, morning headaches and sinus headaches, plus the organic, migraine, cluster, trauma, TMJ, eyestrain, rebound, exertion, hormonal and muscle tension varieties. You may also suffer the self-induced hangover and toxicity headaches.
Americans are no strangers to self-medication, and as a society we battle these headaches by consuming nearly 80 billion tablets of aspirin each year, about 20 million aspirins a day, according to Burton Goldberg, co-author of An Alternative Medicine Definitive Guide to Headaches (Future Medicine Publishing). And while we drown ourselves in over-the-counter and powerful prescription products, our tolerance, just like a drug addict's, grows. So what begins as a twodose headache slowly evolves into three, four or five doses, until you realize that no dosage can make your headache go away.
Unless you're fond of medieval practices such as ritualistic healings and bloodletting, drugs seem the only answer to headache misery. But even modern medicine has been unable to solve headaches. Rather than a cure, medications provide only temporary relief, and even that isn't guaranteed. Additionally, over-reliance on medications can lead to chronic head pain. According to Goldberg, rebound headaches often result from the consumption and withdrawal of drugs.
Halt Your Headaches
Rather than strive to simply eliminate headache pain, why not identify the underlying cause and prevent the headache? Almost always, every type of headache results from a health or lifestyle-related activity. In an ideal world, the best approach would be to eliminate the tensions, stress, frustrations, anger, insufficient sleep, excessive drinking and poor diet that contribute to your headaches. For better or for worse, however, you can't always: a. quit your job; b. ask your spouse to leave; c. sit on the beach all day; or d. all of the above. But you can make appropriate lifestyle changes and learn to express SUPPRESSED feelings.
This approach, lifestyle modification, is a treatment program based on a Loma Linda University study, originally published in Medical Hypothesis and the Journal of Women's Health and Gender-Based Medicine and later explained in No More Headaches, No More Migraines: A Proven Approach to Preventing Headaches and Migraines by Zuzana Bic, DrPH and L. Francis Bic, PhD (Avery). The program, conducted on a group diagnosed with chronic migraines, dramatically decreased the frequency, intensity and duration of headaches in nine of 10 headache sufferers. Rather than demand radical life changes, the lifestyle modification program introduces gradual changes in three specific areas: nutrition, exercise and understanding stress. The study doesn't expect you to change your entire diet, join a gym and eliminate everything that triggers stress, but teaches techniques to make subtle lifestyle changes and reduce the impact of daily stress. These same techniques can also improve sleep patterns, a factor known to affect headaches. The lifestyle modification approach clarifies that while very few headaches directly result from existing acute conditions, recurring headaches often derive from a larger lifestyle factor. If these issues are ignored, the body's natural defense mechanisms may kick into overdrive and become exhausted, leaving you susceptible to other chronic diseases. By finding and eliminating the cause of your headaches, you may be saving yourself from other eventual illnesses.
Willing to make some lifestyle changes and step away from medications? Try these remedies, courtesy of Nature's Pharmacy by Lynn Paige Walker, PharmD and Ellen Hodgson Brown, JD (Prentice-Hall).
For simple headaches, start with relaxation and neck stretches. Or try rubbing your forehead with peppermint oil, a natural antispasmodic and diuretic shown in German research to be as effective as acetaminophen in easing tension headaches.
Never underestimate the old-fashioned ice pack to the forehead as an effective treatment that works by constricting the swollen blood vessels that cause your head to ache. If the ice pack isn't enough, try putting your arms in icy water up to your elbows to constrict additional blood vessels. But if it's a sinus headache you're fighting, take the opposite approach and try hot compresses.
The herbal, and original, form of aspirin is white willow bark. Used by Chinese practitioners 2,500 years ago, it contains salicin, nearly the same pain reliever found in aspirin. Other herbal aspirins include meadowsweet tea, just as effective as aspirin with few side effects. For migraines, Walker and Brown recommend feverfew and magnesium supplements, which reduce nerve excitability and migraine susceptibility. In fact, individuals with frequent headaches have been found to have low brain and tissue magnesium, says Julian Whitaker, MD, author of Julian Whitaker's Guide to Natural Healing (Prima). For all headaches, Goldberg suggests essential fatty acid supplementation with evening primrose oil (EPO), which improves circulation, helps regulate inflammation and relieves pain.
The Curse of the Migraine
Migraines, a debilitating headache distinguished by a throbbing pain, may be humanity's oldest malady. The name is derived from the word the Greek physician Galen used to describe the disorder in 200 A.D. Six-thousand-year-old Sumerian writings refer to the ravages of migraines, and prehistoric skeletons bear testimony to a crude form of trephination-holes chiseled in skulls to allow the escape of pain-creating demons, according to Lifetime Encyclopedia of Natural Remedies by Myra Cameron (Parker Publishing).
In the common migraine, throbbing pain develops gradually from distended veins around the brain and may be accompanied by nausea, vomiting and sensitivity to light. These miseries can be preceded by 15 to 90 minutes of an "aura," which includes visual disturbances, distorted perception, hallucinations, flashes of light and temporary loss of sight or hearing. In fact, skeptical historians attribute some of the religious visions of the Middle Ages to the visual effects of migraine aura, according to Cameron.
Snacking on high fiber foods between three light meals each day helps stabilize blood sugar and prevent migraines. And while some doctors summarily attribute migraines to diet, other experts attribute at least half of all migraines to food sensitivities. The most common edible villains are aged cheeses, yeast breads, chocolate, cured meats, citrus fruits, eggs, fermented foods, wheat, milk, milk products, alcoholic drinks and food additives, including nitrates and MSG.
Suggested daily supplements for migraine-susceptible individuals include a multivitamin, one capsule of B complex to help maintain normal vascular control, 3,000 to 6,000 milligrams in divided doses of vitamin C with bioflavonoids to assist the production of anti-stress hormones, and 500 to 1,000 milligrams of magnesium to reduce nerve excitability and pain. At the onset of a migraine, says Cameron, try homeopathic remedies, dilutions of natural substances from plants, minerals and animals. For throbbing pain, take natrum muriaticum according to package directions. Other homeopathic options to explore include iris versicolar, lac defloratum and sanguinaria.
Take Charge of Your Headaches
Headache management involves managing your life. Practice relaxation techniques to reduce stress. Calmly discuss your feelings. Take a leisurely stroll at lunch. Walk your dog, or a neighbor's dog, after dinner. Keep a food diary. Sit and stand tall. Skip the fast food tonight. Join a yoga class. Take vitamins and supplements. Get a two-hour massage. Turn the television off earlier and sleep in a little later.
Taking the time to care may take effort, but it will soon become second nature. Invest in yourself. It's your most precious possession.
Menopause: Disease or Condition?
June 13, 2005 03:44 PM
Menopause: Disease or Condition?
by Mary Ann Mayo & Joseph L. Mayo, MD Energy Times, September 4, 1999
It's front-page news. It's politically correct and socially acceptable. Talking about menopause is in. Suddenly it's cool to have hot flashes. Millions of women turning 50 in the next few years have catapulted the subject of menopause into high-definition prominence.
It's about time. Rarely discussed openly by women (what did your mother ever advise you?), meno-pause until recently was dismissed as "a shutting down experience characterized by hot flashes and the end of periods." Disparaging and depressing words like shrivel, atrophy, mood swings and melancholia peppered the scant scientific menopausal literature.
What a difference a few years and a very vocal, informed and assertive group of Baby Boomers make. Staggered by the burgeoning numbers of newly confrontational women who will not accept a scribbled prescription and a pat on the head as adequate treatment, health practitioners and researchers have been challenged to unravel, explain and deal with the challenges of menopause.
Not An Overnight Sensation
Menopause, researchers have discovered, is no simple, clear cut event in a woman's life. The "change of life" does not occur overnight. A woman's body may begin the transition toward menopause in her early 40s, even though her last period typically occurs around age 51. This evolutionary time before the final egg is released is called the perimenopause. Erratic monthly hormone levels produce unexpected and sometimes annoying sensations.
Even as their bodies adjust to lower levels of estrogen, progesterone and testosterone, some women don't experience typical signs of menopause until after the final period. A fortunate one-third have few or no discomforts.
According to What Your Doctor May Not Tell You About Premenopause (Warner Books) by John R. Lee, MD, Jesse Hanley, MD, and Virginia Hopkins, "The steroid hormones are intimately related to each other, each one being made from another or turned back into another depending on the needs of the body...But the hormones themselves are just part of the picture. It takes very specific combinations of vitamins, minerals and enzymes to cause the transformation of one hormone into another and then help the cell carry out the hormone's message. If you are deficient in one of the important hormone-transforming substances such as vitamin B6 or magnesium, for example, that too can throw your hormones out of balance. Thyroid and insulin problems, toxins, bad food and environmental factors, medication and liver function affect nutrient and hormone balance."
The most important reproductive hormones include:
Estrogen: the female hormone produced by the ovaries from puberty through menopause to regulate the menstrual cycle and prepare the uterus for pregnancy. Manufacture drops significantly during menopause. Estradiol is a chemically active and efficient form of estrogen that binds to many tissues including the uterus, breasts, ovaries, brain and heart through specific estrogen receptors that allow it to enter those cells, stimulating many chemical reactions. Estriol and estrone are additional forms of estrogen.
Progesterone: also produced by the ovaries, it causes tissues to grow and thicken, particularly during pregnancy, when it protects and nurtures the fetus. Secretion ceases during menopause.
Testosterone: Women produce about one-twentieth of what men do, but require it to support sex drive. About half of all women quit secreting testosterone during menopause.
Estrogen's Wide Reach
Since estrogen alone influences more than 400 actions on the body, chiefly stimulating cell growth, the effects of its fluctuations can be far-reaching and extremely varied: hot (and cold) flashes, erratic periods, dry skin (including the vaginal area), unpredictable moods, fuzzy thinking, forgetfulness, fatigue, low libido, insomnia and joint and muscle pain.
Young women may experience premature menopause, which can occur gradually, as a matter of course, or abruptly with hysterectomy (even when the ovaries remain) or as a result of chemotherapy. Under such conditions symptoms can be severe.
In the 1940s doctors reasoned that if most discomforts were caused by diminishing estrogen (its interactive role with progesterone and testosterone were underestimated), replacing it would provide relief. When unchecked estrogen use resulted in high rates of uterine cancer, physicians quickly began adding progesterone to their estrogen regimens and the problem appeared solved.
For the average woman, however, hormone replacement therapy (HRT) became suspect and controversial, especially when a link appeared between extended use of HRT (from five to 10 years) and an increase in breast and endometrial cancers (Journal of Clinical Pharmacology 37, 1997). The result: Women have drawn a line in the sand between themselves and their doctors.
Resolving The Impasse
Since hormone replacement reduces the risk of major maladies like heart disease, osteoporosis, Alzheimer's, colon cancer and diabetes that would otherwise significantly rise as reproductive hormone levels decrease, most doctors recommend hormone replacement shortly before or as soon as periods stop. Hormone replacement also alleviates the discomforts of menopause.
But only half of all women fill their HRT prescriptions and, of those who do, half quit within a year. Some are simply indifferent to their heightened medical risks. Some are indeed aware but remain unconvinced of the safety of HRT. Others complain of side effects such as bloating, headaches or drowsiness.
Women's resistance to wholesale HRT has challenged researchers to provide more secure protection from the diseases to which they become vulnerable during menopause, as well as its discomforts. If the conventional medical practitioners do not hear exactly what modern women want, the complementary medicine community does. Turning to centuries-old botanicals, they have validated and compounded them with new technology. Their effectiveness depends on various factors including the synergistic interaction of several herbs, specific preparation, the correct plant part and dosage, harvesting and manufacturing techniques.
Research demonstrates that plant hormones (phytoestrogens) protect against stronger potentially carcinogenic forms of estrogen while safely providing a hormone effect. Other herbs act more like tonics, zipping up the body's overall function.
Help From Herbs
Clinical trials and scientific processing techniques have resulted in plant-based supplements like soy and other botanicals that replicate the form and function of a woman's own estrogen.
The complementary community also can take credit for pushing the conventional medical community to look beyond estrogen to progesterone in postmenopausal health.
Natural soy or Mexican yam derived progesterone is formulated by pharmacologists in creams or gels that prevent estrogen-induced overgrowth of the uterine lining (a factor in uterine cancer), protect against heart disease and osteoporosis and reduce hot flashes (Fertility and Sterility 69, 1998: 96-101).
A quarter of the women who take the popularly prescribed synthetic progesterone report increased tension, fatigue and anxiety; natural versions have fewer side effects.
These "quasi-medicines," as Tori Hudson, a leading naturopathic doctor and professor at the National College of Naturopathic Medicine, Portland, Oregon, calls them, are considered "stronger than a botanical but weaker than a medicine." (Hudson is author of Gynecology and Naturopathic Medicine: A Treatment Manual.)
According to Hudson, the amount of estrogen and progesterone in these supplements is much less than medical hormone replacement but equally efficacious in relieving menopausal problems and protecting the heart and bones.
According to a study led by Harry K. Genant, PhD, of the University of California, San Francisco, "low-dose" plant estrogen derived from soy and yam, supplemented with calcium, prevents bone loss without such side effects as increased vaginal bleeding and endometrial hypoplasia, abnormal uterine cell growth that could be a precursor to endometrial cancer (Archives of Internal Medicine 157, 1997: 2609-2615).
These herbal products, including natural progesterone and estrogen in the form of the weaker estriol or estrone, may block the effect of the stronger and potentially DNA-damaging estradiol.
Soy in its myriad dietary and supplemental forms provides a rich source of isoflavones and phytosterols, both known to supply a mild estrogenic effect that can stimulate repair of the vaginal walls (Journal of the National Cancer Institute 83, 1991: 541-46).
To enhance vaginal moisture, try the herb cimicifuga racemosa, the extract of black cohosh that, in capsule form, builds up vaginal mucosa (Therapeuticum 1, 1987: 23-31). Traditional Chinese herbal formulas containing roots of rehmannia and dong quai have long been reputed to promote vaginal moisture.
Clinical research in Germany also confirms the usefulness of black cohosh in preventing hot flashes and sweating, as well as relieving nervousness, achiness and depressed moods caused by SUPPRESSED hormone levels. It works on the hypothalamus (the body's thermostat, appetite and blood pressure monitor), pituitary gland and estrogen receptors. Green tea is steeped with polyphenols, mainly flavonoids, that exert a massive antioxidant influence against allergens, viruses and carcinogens. The risks of estrogen-related cancers such as breast cancer are particularly lowered by these flavonoids, as these substances head directly to the breast's estrogen receptors. About three cups a day exert an impressive anti-inflammatory, antiallergenic, antiviral and anticarcinogenic effect.
Other phytoestrogen-rich botanicals, according to Susun Weed's Menopausal Years: The Wise Woman Way (Ash Tree Publishing), include motherwort and lactobacillus acidophilus to combat vaginal dryness; hops and nettles for sleep disturbances; witch hazel and shepherd's purse for heavy bleeding; motherwort and chasteberry for mood swings; dandelion and red clover for hot flashes.
Our Need For Supplements
Adding micronutrients at midlife to correct and counter a lifetime of poor diet and other habits is a step toward preventing the further development of the degenerative diseases to which we become vulnerable. At the very minimum, you should take:
a multivitamin/mineral supplement vitamin E calcium
Your multivitamin/mineral should contain vitamins A, B complex, C, D, E, calcium, magnesium, potassium, copper and zinc. Look for a wide variety of antioxidants that safeguard you from free radical damage, believed to promote heart disease and cancer, as well as contribute to the aging process.
Also on the list: mixed carotenoids such as lycopene, alpha carotene and vitamin C; and folic acid to help regulate cell division and support the health of gums, red blood cells, the gastrointestinal tract and the immune system.
Studies indicate a deficiency of folic acid (folate) in 30% of coronary heart disease, blood vessel disease and strokes; lack of folate is thought to be a serious risk factor for heart disease (OB.GYN News, July 15, 1997, page 28).
Extra vitamin E is believed to protect against breast cancer and bolster immune strength in people 65 and older (Journal of the American Medical Association 277, 1997: 1380-86). It helps relieve vaginal dryness, breast cysts and thyroid problems and, more recently, hit the headlines as an aid in reducing the effects of Alzheimer's and heart disease. It is suspected to reduce the thickening of the carotid arterial walls and may prevent the oxidation of LDL (bad) cholesterol, which contributes to the formation of plaque in arteries.
Selenium also has been identified as an assistant in halting cancer (JAMA 276, 1996: 1957-63).
The Omegas To The Rescue
Essential fatty acids found in cold water fish, flaxseed, primrose and borage oils and many nuts and seeds are essential for the body's production of prostaglandin, biochemicals which regulate hormone synthesis, and numerous physiological responses including muscle contraction, vascular dilation and the shedding of the uterine lining. They influence hormonal balance, reduce dryness and relieve hot flashes.
In addition, the lignans in whole flaxseed behave like estrogen and act aggressively against breast cancer, according to rat and human studies at the University of Toronto (Nutr Cancer 26, 1996: 159-65).
Research has demonstrated that these omega-3 and omega-6 fatty acids can reverse the cancer-causing effects of radiation and other carcinogens (Journal of the National Cancer Institute 74, 1985: 1145-50). Deficiencies may cause swelling, increased blood clotting, breast pain, hot flashes, uterine and menstrual cramps and constipation. Fatigue, lack of endurance dry skin and hair and frequent colds may signal EFA shortage. Plus, fatty fish oils, along with vitamin D and lactose, help absorption of calcium, so vital for maintaining bone mass.
In addition, studies show that the natural substance Coenzyme A may help menopausal women reduce cholesterol and increase fat utilization (Med Hyp 1995; 44, 403, 405). Some researchers belive Coenzyme A plays a major role in helping women deal with stress while strengthening immunity.
Can't shake those menopausal woes? Menopause imposters may be imposing on you: The risk of thyroid disease, unrelenting stress, PMS, adrenal burnout, poor gastrointestinal health and hypoglycemia all increase at midlife. Menopause is a handy hook on which to hang every misery, ache and pain but it may only mimic the distress of other ailments. For this reason every midlife woman should have a good medical exam with appropriate tests to determine her baseline state of health. Only with proper analysis can you and your health practitioner hit on an accurate diagnosis and satisfying course of therapy.
And if menopause is truly the issue, you have plenty of company. No woman escapes it. No woman dies from it. It is not a disease but a reminder that one-third of life remains to be lived. Menopausal Baby Boomers can anticipate tapping into creative energy apart from procreation. If not new careers, new interests await. An altered internal balance empowers a menopausal woman to direct, perhaps for the first time, her experience of life. She has come of age-yet again. Gone is the confusion, uncertainty, or dictates of a hormone driven life: This time wisdom and experience direct her. There is no need to yearn for youth or cower at the conventional covenant of old age. Menopause is the clarion call to reframe, reevaluate and reclaim.
Mary Ann Mayo and Joseph L. Mayo, MD, are authors of The Menopause Manager (Revell) and executive editors of Health Opportunities for Women (HOW). Telephone number 877-547-5499 for more information.
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
June 09, 2005 05:22 PM
The Latest Breakthroughs in Garlic Research
on Cancer and Cardiovascular Disease
Presented at the 2005 World Garlic Symposium
Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.
“For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”
Presentation highlights included:
Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.
“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”
Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .
PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892
Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with SUPPRESSED tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.
INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA
Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.
INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany
Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.
David Heber, MD, PhD, FACP, FACN
Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center
Matthew Budoff, MD, FACC
Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.