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Advantages of taking Multiple Vitamin and Mineral Pills Darrell Miller 1/16/14
Horsetail Darrell Miller 8/31/09
Honey from bee's Darrell Miller 7/1/09
L-Carnitine Darrell Miller 5/7/09
L-Alanine Non Essential Amino Acid Darrell Miller 1/5/09
Are Inflammation, Immunity, And Allergic Reactions A Role For Supplements? Darrell Miller 11/10/07
The Awesome Foursome: Coenzyme Q10, D-Ribose, L-Carnitine, and Magnesium Darrell Miller 5/18/07
Complete Liver Cleanse Darrell Miller 4/19/07
Supplements good for reducing stress and boosting energy! Darrell Miller 3/26/07
The Important Role of Nutritional Magnesium & Calcium Balance in Humans Living with Stress Darrell Miller 8/23/06
The unique clinical benefits of Sun Chlorella Darrell Miller 3/25/06
Astaxanthin - PHYTONUTRIENT ANTIOXIDANT Darrell Miller 12/28/05
Anti-Aging Nutrients Darrell Miller 6/18/05
Nutrients for Longevity Darrell Miller 6/10/05




Advantages of taking Multiple Vitamin and Mineral Pills
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Date: January 16, 2014 06:19 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Advantages of taking Multiple Vitamin and Mineral Pills

Multiple Vitamin and Mineral pills

fruits and vegetablesMultiple vitamins, also known as multivitamins are dietary supplements containing vitamins and dietary minerals, among other important elements. These supplements often are in the form of capsules, tablets, injections and syrup. They are normally provided in conjunction with dietary minerals. The minerals provided by these supplements fulfill various roles in the body. Research findings have indicated that taking multiple vitamins does not protect you from diabetics, heart attacks, cancer, among other lifestyle diseases. Nonetheless, some categories of people like malnourished people and people with an increased chance of macular deterioration. Overally, the benefits of taking a multivitamin daily exceed the probable risks associated with them.

Reasons for taking these pills

Enhancing nutrient intake

For people who cannot get the recommended nutrient amounts, these people are urged to take supplements so as to boost their diet. Processed and inorganically grown food have been depleted of their vitamins and essential minerals. It is for this reason that it is suggested to take multivitamins and minerals daily to supplement your dietary intake. People essentially take dietary supplements to back up their food intake.

Improving your health and suppression of recurrent diseases

Specific supplements can be very helpful for individuals with particular diseases. Increasing your daily dose of vitamins and minerals is likely to slow down loss of vision. Studies have also indicated that taking multivitamins lowers the risk of developing growth in the large intestines. The folate in multivitamins is thought to be responsible for this protection.

Do you really have to take these pills?

In as much as multivitamins cannot take the place of real food, it is imperative to get extra vitamins and nutrients for people taking incomplete diets. One advantage of these supplements is that they offer higher nutrient returns with low calories unlike regular food. They are also recommended for pregnant, breastfeeding and post-menopausal women.

As the old adage goes; your health is in your hands, start taking nutritional supplements today to enjoy the advantages a balanced diet has to offer.

References:

  1. //ods.od.nih.gov/factsheets/MVMS-QuickFacts/
  2. //hsph.harvard.edu/nutritionsourece/multivitamins/
  3. //en.wikipedia.orrg/wiki/Multivitamin


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Horsetail
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Date: August 31, 2009 01:36 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Horsetail

Horsetail has been used for healing in both Chinese and Asian cultures. During times of famine, the Romans ate horsetail shoots, while Native Americans used horsetail as a diuretic for kidney problems, cancer, and dropsy to increase blood circulation. The Hopi tribe in New Mexico mixed horsetail and cornmeal as a mush and in their bread. One of the oldest plants on the earth, horsetail is approximately two hundred million years old. It used to be a giant fernlike plant. However, there are now around twenty species of the original plant living today. These species are small in comparison to the original plant and are usually considered to be a nuisance. The species Equisetum arvense is a small perennial fern plant that is most common in North America.

The horsetail plant is a descendent of huge tree-like plants that thrived 400 million years ago during the Paleozoic era. The plant is a non-flowering weed that can be found throughout parts of Europe, Asia, the Middle East, and North America. This plant returns each year with hollow stems and shoots that resemble asparagus. As the plant dries, silica crystals, which form in the stems and branches, give the plant the scratching effect that made it historically useful for polishing metal.

Horsetail is believed to aid the immune system and the nervous system because of its silica content. The nerves contain almost the same amount of silica as does the albumin in the blood. The pancreas is especially rich in silica. Silica is found combined with fluorine in the enamel of the teeth. Additionally, hair needs silica to grow, and it is needed as a protection for the skin and cell walls. This herb helps in treating urinary tract problems. It contains silicic acid, which is responsible for helping with circulation of the blood. This herb is also credited with helping coagulate the blood and decreasing blood flow. An externally-applied decoction has the ability to stop bleeding of wounds and help with healing. Horsetail can also be used as a mouthwash for mouth infections. Often found in calcium combinations, horsetail is helpful in building the skeletal system and improving bone structure. The silica that is found in horsetail also helps in healing bones, keeping the arteries clean, and facilitating the absorption of calcium in the body.

This herb is known for its antibiotic properties and its contribution to the overall healing process. Horsetail is also thought to help with bleeding, urinary and prostate disorders, bed-wetting, skin problems, and lung disease. Horsetail also possesses a weak diuretic effect, which is most notably due to the equisetonin and the flavone glycosides.

In short, the entire horsetail herb is used to provide alterative, antilithic, antineoplastic, astringent, diuretic, emmenagogue, galactogogue, lithotriptic, nephritic, nutritive, and vulnerary properties. The primary nutrients found in this herb are flavonoids, iodine, iron, manganese, PABA, pantothenic acid, silicon, sodium, and vitamin E. Primarily, this herb is extremely beneficial in treating arthritis, poor circulation, diabetes, glandular problems, weak hair, kidney stones, weak nails, nervousness, osteoporosis, parasites, rheumatism, and urinary problems.

Additionally, this herb is very helpful in dealing with edema, eyestrain, gas, gout, heart problems, hemorrhage, incontinence, liver disorders, membrane irritations, neuralgia, palsy, skin disorders, tumors, and water retention. For more information on the many beneficial effects provided by horsetail, please feel free to contact a representative from your local health food store.

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Honey from bee's
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Date: July 01, 2009 12:12 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Honey from bee's

Bees make honey out of the nectar that they sip from flower blossoms. A long and tedious process is necessary to transform nectar into the thick, golden substance that we call honey. Like each product that is produced by the honeybee, care and a number of steps are essential in order to create this beehive food, with honey being no exception. This sweet, nutritious edible substance is a viscous fluid that is exclusively created by the honeybee. Even the most sophisticated modern techniques have failed to synthetically manufacture honey. Like royal jelly, propolis, and bee pollen, honey is only available from Mother Nature. It is a precious and coveted substance that has fascinated and pleased cultures throughout time.

The ancient Greeks called honey one of nature’s most precious gifts, while the Assyrians, Chinese, and Romans routinely prescribed it for its medicinal value. Numerous biblical references refer to the “Honeycomb” and the “Land of Milk and Honey,” as well as the “Enlightenment” that comes from eating honey. Hippocrates recorded that a honey drink cures phlegm and calms down a cough. He was one of the first known advocates for using Honey and Vinegar for fevers and other ailments. All of ancient cultures believed that the use of honey each and every day would insure health and longevity. All kinds of wines and foods were routinely mixed with honey, causing them to be viewed by all peoples as a treasure which the gods provided for health.

Of all the ancient cultures, Egyptians prized honey enough to use it as a form of money. Hieroglyphics often refer to honey as the universal healer and jars of honey were routinely placed in tombs of the dead. Because of its superior preservative properties, honey used to be an integral part of the formula that was used in the mummification process. Throughout all of history, honey has been used to treat open wounds and fight infection. Unfortunately, the advent of refined sugar caused honey to take a back seat to other more popular sweeteners. Thankfully, today honey is experiencing resurgence, as it was once an often overlooked beehive food that is full of nutritive and medicinal value.

When a bee lands on a flower, it sucks a tiny amount of nectar to its honey sac. It is within this sac that the transformation of nectar to honey begins. The nectar is mixed with acid secretions to eventually form the coveted honey that we consume. Substantial amounts of nectar are necessary to produce significant amounts of honey, making flying the distance of up to three miles necessary to obtain the amounts of nectar that is needed to fill the sac. Once the sac is full, the honeybee returns to the hive, where a receiving bee takes the nectar and continues the process, changing, enriching, and concentrating the nectar. Following this, the receiving bee drops the mixture into the empty cells of the honeycomb.

In order to produce a single pound of honey, bees must provide the hive with over 70,000 loads of nectar. A healthy beehive can produce about 300 pounds of honey each season. The health benefits of honey have now been captured by manufactures like Premier one and Montana big sky. Natural honey is available in liquid form at your local or internet health food store. Look for name brands to ensure quality and purity of the product you purchase.

*Statements contained herein have not been evaluated by the Food and Drug Administration. Honey is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.

Fine Honey Products from Premier one are available at VitaNet ®, LLC Health Food Stores.

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L-Carnitine
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Date: May 07, 2009 05:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: L-Carnitine

L-carnitine is amino acid essential for the metabolism of fats into a form of energy necessary for extended aerobic activity. Originally discovered in Russia, and Germany a year later, the structural formulation of carnitine, as it is correctly known, was determined in 1927, although it is physiological and biochemical activity was not understood until the 1960s.

The amino acid is biosynthesized in the liver and kidneys from lysine and methionine. The vitamins niacin, B6, C and iron are essential for this reaction to take place. However, the supply of L-carnitine has to be supplemented by the diet, good sources being dairy products, red meat, nuts and seeds, pulses and fruits such as apricots, bananas and avocado. Most of the L-carnitine supply of the body is stored within the muscle tissue. However, it is not unusual for conditions to arise making it difficult for the body to obtain all the carnitine required.

L-carnitine enables fatty acids to be transported into the mitochondria, where cell metabolism occurs. The biochemistry is discussed below, although in simple terms the amino acid allows body fats, in the form of triglycerides, to be made more readily available for the generation of energy required for extended exertion. In this way, body fats can be used for energy and the supplies of glycogen stored by the liver can be retained for emergency use.

By providing the energy for endurance and stamina in this way, carnitine makes use of an otherwise unavailable energy source, and has the added benefit of reducing body fat stores and reducing strain on the heart.

Although there is generally a plentiful supply of L-carnitine available in a healthy diet, supplementation can ensure that a deficiency does not occur. Supplements are available in the form of L-carnitine or its acetylated derivative, acetyl L-carnitine.

In order for fatty acids to be used in the production of energy, their long-chain acetyl groups have to get inside the mitochondria where they are oxidized to the acetate to be used for the production of energy via the Citric Acid or Krebs cycle.

In order for the biochemistry to take place, fatty acids must be rendered suitable for binding to the carnitine molecule. The chemical grouping with a good affinity for L-carnitine is the acetyl or acetyl group, available in the molecule acetyl coenzyme A (CoA). The free fatty acid, therefore, is attached to coenzyme-A by means of a thioester bond, catalyzed by means of the enzyme fatty acetyl-CoA synthetase. The reaction is then completed by means of in organic pyrophosphatase.

In this way, the fatty acid in the form of an acetyL-carnitine derivative can be transported through the mitochondrial wall. This transportation takes place by means of several steps. These are:

1. As explained, the acetyl-CoA is attached to L-carnitine by means of the enzyme carnitine acetyltransferase I. This enzyme is conveniently located on the outer mitochondrial membrane.

2. The enzyme carnitine-acetylcarnitine translocase helps the acetyL-carnitine through the membrane.

3. Another enzyme, carnitine acetyltransferase II, located on the inner mitochondrial membrane, converts the acetyL-carnitine to acetyl-CoA, liberating the carnitine which returns to the muscle mass.

L-carnitine is the only known substance that allows fatty acids to cross the mitochondrial membrane, and therefore deficiencies must be avoided.

Another way in which carnitine is used in energy production is in the Krebs cycle itself. Part of this cycle involves the conversion of guanine diphosphate to the higher energy form guanine triphosphate. In this way energy can be stored in much the same way as it is in the conversion of ADP to ATP. Succinyl CoA is involved in this conversion, and one of the by-products of it is a corresponding succinate, that is then converted to a fumarate by the action of L-carnitine fumarate. Carnitine, therefore, has two parts to play in the production of long-term energy from the fatty acids contained in body fats.

Since the fatty acid triglycerides contained in body fats are a major source of energy in the heart and skeletal muscles, it is easy to understand how L-carnitine is believed to lead to the increased energy levels required for stamina and staying power. A major reason for its effect on longer-term or extended energy requirements is that in enabling stored body fats to be used for immediate and longer-term energy requirements, L-carnitine allows emergency glycogen stores to be retained for use once immediate fatty acid supplies or those of carnitine have been depleted, and so allows the energy supply to be extended even farther. Research has also suggested that the amino acid can possibly be used to treat liver and kidney disease, diabetes and chronic fatigue syndrome.

As with many supplements, the question is often asked how does L-carnitine work in practice as opposed to the claims made for it by the supplement providers? Recent research indicates mixed results, but sufficient to justify its use. It is generally accepted that a supplement is necessary when there is a deficiency, but once that deficiency has been corrected further intake is unnecessary. However, it is also believed that during long and extended periods of exercise a carnitine deficiency does occur as L-carnitine is used up, and the supplement is necessary to ensure sufficient energy supply throughout the period of exercise.

There has also been a case reported in the Journal of Clinical Neurology (Negoro, Tsuda, Kato & Morimatsu, 1995) where a deficiency, caused by anorexia nervosa damaging the liver to the extent that it was unable to synthesize L-carnitine, was remedied by means of an oral supplement. Studies on endurance athletes have been mixed, ranging from no effect to L-carnitine being found to promote weight loss.

Carnitine has no unknown harmful side effects, and has been studied for medical applications other than as an energy supplement. For example it possesses extensive antioxidant properties, and can be used as a supplement against oxidative stress and the prevention of the lipid peroxidation that is a precursor to atherosclerosis.

Its use in osteoporosis and reducing bone mass is also being studied. The concentration of L-carnitine diminishes with age, and affects fatty acid metabolism in a number of tissues. Bones are particularly affected since they require continuous reconstruction. Without detailing the biochemistry involved in this, administration of carnitine helps to reduce the speed by which this occurs. Trials are so far been carried out only on animals.

In studies on both healthy volunteers and patients with type II diabetes, L-carnitine was found to improve storage of glucose in both groups, although its oxidation increased only in the group with diabetes. Other studies carried out include improving the function of neurotransmitters in the brains of elderly patients and in the treatment of Alzheimer's and Parkinson's disease, and other neurological disorders.

In conclusion then, although the jury is out on the use of L-carnitine is an energy-giving or weight-loss supplement, it appears to be effective where the body's stores of carnitine could be depleted such as with long-term exercise, natural deficiencies or deficiencies caused through age. It is also under study in the treatment of various medical conditions. On balance, it would appear that the prospective benefits of L-carnitine render it worthy of use.

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L-Alanine Non Essential Amino Acid
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Date: January 05, 2009 04:31 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: L-Alanine Non Essential Amino Acid

L-Alanine is one of 20 amino acids that are used by the body to manufacture the proteins essential for life. Each protein possesses specific biological properties that are imparted by the sequence of amino acids it contains. Proteins control the chemistry that takes place within the cells of our body, and comprise all of the enzymes that catalyze the body's biochemistry.

Amino acids are also the building blocks of DNA that determines the genetic make-up of individuals, and that also provides recipes or templates for the production of proteins from amino acid sequences. There is a different DNA template for every protein required by the body that determines which of the 20 amino acids are needed, and in what order they are to be combined with one another to manufacture the desired protein.

10 of these 20 amino acids can be synthesized by your body's biochemistry, the other 10 being essential parts of your diet. If you fail to include just of these 10, then your body will break down its proteins until it has obtained a sufficient supply of that amino acids for its needs. That involves muscle and other tissue degradation, and is one of the symptoms of malnutrition. Amino acids are not stored, and a daily supply is essential to avoid these symptoms.

L-Alanine is one of the ten that the body can manufacture, and used by the body to help build protein and also to enable the body to make use of glucose to generate energy. It does so as part of what is known as the glucose-alanine cycle. During anaerobic exercise, such as in weightlifting and sustained running, muscles produce lactate and also alanine.

The alanine is passed on to the liver where it is converted to energy via its conversion to glucose. This is not a particularly efficient means of creating energy because a byproduct of the process is urea, the removal of which in turn requires energy. However, it serves its purpose as an energy source once the liver is depleted of glycogen. In fact that is the major use to which alanine appears to be put by the body: the conversion of glucose to energy.

The way the glucose-alanine cycle works is that a process known as transamination produces glutamate from the amino groups of amino acids that are degraded during exercise. Glutamate is then converted to pyruvate by means of the enzyme alanine aminotransferase, with the production of alanine and alpha-ketoglutarate. This is a reversible reaction, and after the alanine has been carried by the bloodstream to the liver, the reaction reverses with the regeneration of pyruvate that undergoes gluconeogenesis (generation of glucose).

The result of this is glucose that returns to the muscle tissue to provide more energy. The glutamate is broken down to the ammonium ion in the mitochondria, which in turn enters the urea cycle with the production of urea.

In a nutshell, then, the glucose-alanine cycle removes glutamate and pyruvate from muscle tissue to the liver where glucose is generated from the pyruvate and returned to the muscle. Since gluconeogenesis involves the expenditure of energy, and this occurs in the liver rather than in the muscle, all the energy in the muscle can be used for muscle contraction.

L-Alanine possesses other properties, among them the ability to help maintain the health of the prostate. A study of benign prostatic hyperplasia (enlarged prostate) indicated that treatment with L-alanine, glutamic acid and glycine over a period of three months reduced the symptoms. However, make sure that you consult your physician before using alanine in this way. This is not because there are any known adverse side effects, because there are not, but because it I always wise to so with any supplement taken with a view to treating any medical condition.

A less obvious application derives from the fact that it forms a stable free radical when deaminated. Deamination can be initiated by radiation, and so the concentration of this free radical can be measured to ensure that the correct dose of radiation is being given in dosimetric radiotherapy. It is not always easy to control the dose accurately, and this property of alanine allows it to monitored and to ensure that it is neither too low to have the desired effect, nor dangerously high.

Although it is a non-essential amino acid, and can be produced by the body, a dietary supply or supplement is advantageous if extra energy is required. Good dietary sources of L-alanine include meats, seafood, eggs, nuts, beans, seeds, brewer's yeast, corn and legumes among others. Supplements are also available, and useful for body-builders, weightlifters and others involved in anaerobic exercise. Due to the glucose-alanine cycle, it can possibly provide energy when lactate build-up would otherwise lead to muscle cramps.

Those for whom a supplement could be useful are athletes and others who are trying to build muscle and stamina, or reduce their body fat and also the obese and overweight for the same reason. There is also evidence that a combination of the amino acids alanine, glycine and arginine can help to reduce arterial plaque from oxidized low density lipoproteins, and can also help to reduce high blood pressure.

Deficiencies are rare, although groups that do not eat meat should be careful to eat foods with a good alanine content. There are no known side effects of a deficiency since the body will generate what is needed for normal purposes, and while the supplement appears to have no side effects, it is advisable that pregnant and lactating women should first seek medical advice. The same applies if you suffer from hypertension or diabetes. High doses of alanine might also affect those with kidney or liver disease.

Although the benefits of supplementation of L-alanine might not be immediately obvious, the results and the science indicate that it is effective in making better use of blood glucose in that the adenosine triphosphate (ATP) created in the muscle tissue is allowed to be expended on muscle contraction while the glucose-alanine cycle provides the energy needed for gluconeogenesis.

--
Buy Discount Amino Acids at Vitanet ®, LLC

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Are Inflammation, Immunity, And Allergic Reactions A Role For Supplements?
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Date: November 10, 2007 11:29 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Are Inflammation, Immunity, And Allergic Reactions A Role For Supplements?

Inflammation, immunity diseases and allergic reactions are all connected with your immune system, and the way the body reacts to what it considers to be foreign invaders that are a risk to your health. Although you may not understand that all three have the basic underlying cause, in fact they do, and here is why.

Inflammation manifests as pain and swelling in the inflamed area, and not only can the area also get hot, but it can also raise your temperature in general, commonly called a fever. Fever is the body’s way of raising temperature above that at which foreign organisms such as bacteria and viruses can live, so any inflammatory condition that results in fever by definition must be an immune response through the body trying to eliminate foreign invaders.

If your body gets injured in any way, your immune system responds, and usually calms down again if decides that the injury is not serious. Your immune system is actually initiated by what are known as pro-inflammatory hormones, such as prostaglandins that stimulate the nerves to signal pain and swell the blood vessels close to the injury to make room for the large white blood cells when they arrive. That also allows blood and plasma to rush out and cause swelling at the site of the injury. Other prostaglandins act to quell the immune response, and get your body back to normal.

Another such hormone is a cytokine, which informs the brain of the intrusion. Some cytokines called leukocytes stop the immune system when necessary to prevent the destruction of healthy tissue, and also halt the inflammatory response. If the leukocytes are not working properly, the body can be severely damaged as the immune system becomes uncontrolled and starts to attack healthy tissue.

Then there are the histamines that allow you to expel the agents causing the problem by sneezing, watery eyes, runny noses and scratching. They lead lymphatic fluid and blood to the site of the problem in order that the invasion can be attacked and destroyed.

It is the histamines that provide what is commonly referred to as an allergic reaction, which is really the immune system coming into action to remove invaders such as pollen, dust mites and any other agent that can cause an allergy. Immunity is caused by introducing small amounts of the agent into the blood, so that the immune system can develop a memory of them. Then, when the same invader returns at a later date, the system can immediately attack them with the antibodies that have been produced.

All of these: inflammation, immunity and allergies, are caused by the reaction of the immune system to what it perceives as an invader. Normally these are bacteria and viruses, but sometimes they react to other foreign bodies such as pollen. In some people this provokes no response at all, while in others it provokes the immune system to create antibodies against the pollen, and emit histamine to expel it.

Substances that cause allergies are referred to as allergens. Many allergens are environmental, such as dust, pollen and peanuts. Some people are allergic to certain animals, such as cats or dogs, and others to chemicals in the air such as hydrocarbon emissions, particularly when in particulate form.

The symptoms can be simple, such as a runny nose, a cough and hay fever or more complex such as hives, eczema and asthma. All of these are caused by the immune system reacting to an invader. There are also foods that cause internal inflammation, such as shellfish and whitefish, eggs and tomatoes. Many of these can be extreme, leading to serious illness and can even be fatal. So what can be done to treat people who are particularly prone to inflammation and allergic reactions?

Omega-3 fatty acids have been found to reduce inflammation, unlike their Omega-6 cousins that appear to increase it. Omega-3 oils contain chemicals known as eicosanoids, of which the prostaglandins are an example. While this might seem paradoxical, since prostaglandins are what set off the whole process, there are many types of these. Prostaglandin E2 is the type that leads to allergic immune reactions, and omega-3 fatty acids reduce the concentration of these in the blood.

Those who eat little fish tend to suffer more from inflammatory conditions such as arthritis and other conditions indicating a lack of control of the immune system. On the other hand, processed foods contain more omega-6 fatty acids that can promote these conditions. The major components of omega-3 oils are alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) and also DHA, docosahexaenoic acid. These are all anti-inflammatories and have been shown to have very positive effects on inflammatory conditions such as rheumatoid arthritis, Crohn’s disease and eczema. Each of these is a different type of inflammatory condition caused by inappropriate immune response.

However, it not just fish oils that can help resolve problems with our immune system. Quercetin is what is known as a flavonoid. It is a strong anti-oxidant and natural anti-histamine that combats histamine release and the swelling associated with the immune response to allergens. It also counters the inflammatory agents of arthritis and so helps to reduce the pain associated with many of these conditions. It appears to work better in conjunction with bromelain, a very powerful anti-inflammatory that also possesses anti-allergen response properties. Bromelain is extracted from pineapple stems.

Another natural product is a resin extract that is obtained from the Boswellia serrata tree. It has powerful anti-inflammatory properties, and has been recommended for the treatment of arthritis (rheumatoid and osteo), Crohn’s disease and has been suggested as a treatment for asthma, though studies are still under way. However, world wide experience is that Boswellia is effective against gout, psoriasis and ulcerative colitis, to name another three totally different inflammatory conditions.

What all of this indicates are two things. First that inflammation, immunity and allergic reactions are connected conditions, and due to either poor control over or an over stimulated immune response to what the body perceives as being abnormal, in the way that hormones and other chemicals that are used to control our immunity detect it to be.

Secondly, there are many natural products that can be used as supplements to treat these effects caused by the immune system, and that their effectiveness has been proven, if not by scientific study, then by generations of traditional application as treatments of the symptoms of the conditions concerned.

However, although many have been proved by scientific study, others have not, and you should always refer to your physician before undergoing any treatment other than that prescribed. Also, there is incontrovertible evidence that the role for supplements in the treatment of inflammation, immunity and allergic reactions are beneficial. Many use nothing else.

--
Dietary Supplements

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The Awesome Foursome: Coenzyme Q10, D-Ribose, L-Carnitine, and Magnesium
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Date: May 18, 2007 01:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Awesome Foursome: Coenzyme Q10, D-Ribose, L-Carnitine, and Magnesium

The Awesome Foursome: Coenzyme Q10, L-Carnitine,

D-Ribose, Magnesium

 

The “Awesome Foursome” of Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium helps our hearts metabolize energy more efficiently and protects them from the stress of cardiovascular disease. This powerful combination of nutrients goes directly to the basic biochemistry of cellular energy metabolism. Now let’s take a closer look at how Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium work in synergy to promote cardiovascular health.

 

Coenzyme Q10:

Energy Recycling through the Electron Transport Chain

Coenzyme Q10 is a powerful antioxidant that helps protect the mitochondrial membrane, mitochondrial DNA, and cell walls from free-radical attack. But its most important function in the body is its central role in energy metabolism.

Most – about 90 percent – of the ATP used by cells is recycled as food (fuel) and oxidized in the mitochondria. Fatty acids, carbohydrates, and, occasionally, proteins are carried across the mitochondrial membrane and enter the Krebs’ cycle, moving from step to step and spinning off electrons. These electrons are then handed off to the electron transport chain, where, in the presence of oxygen, the energy from the electrons is captured as a phosphate group is added to ADP to form ATP. This recycling of ATP is called oxidative phosphorylation, and the by-products of these pathways are CO2 and water.

In this fashion, Coenzyme Q10 acts as a gatekeeper of electrons, making sure they are carried to just the right place to pass on their life-giving energy.

What is critical, however, is the simple fact that without Coenzyme Q10 the electron transport chain would totally break down. And since the electron transport chain is (by far!) the largest contributor to cellular energy turnover, its loss would be catastrophic. It is also important to know that there has to be an excess of Coenzyme Q10 in the mitochondria to be maximally effective. Having just enough isn’t sufficient to do the job properly, and having a deficiency seriously affects the mitochondria’s ability to supply the cell with energy.

Cellular stress can cause Coenzyme Q10 deficiency, which places a severe strain on Coenzyme Q10 availability. People with heart disease, hypertension, gingival disease, Parkinson’s disease, and the other disorders we’ve discussed are known to be deficient in Coenzyme Q10. Whether these deficiencies are the cause or the effect of these varied medical problems, the end result is that they sap the life out of their mitochondria and reduce their energy supplies. You see, Coenzyme Q10 cannot function properly if electrons are not coming out of the Krebs’ cycle, and the Krebs’ cycle won’t work without the fuel that’s transported into the mitochondria by L-Carnitine.

 

L-Carnitine:

Transporting the Cellular Energy Fuel

Fatty acids are the preferred energy fuel for hearts and most other cells in the body. L-Carnitine facilitates the beta oxidation of fatty acids as energy fuel. And since fatty acids are the preferred fuel for energy recycling in cells, this action is critical to cell and tissue function. Unfortunately, L-carnitine is deficient in people with heart disease, peripheral vascular disease, lipid metabolic disorders, mitochondrial disorders, and many other disease syndromes we reviewed earlier. This L-carnitine deficiency disrupts the normal metabolism of fatty acids, reducing available energy supplies and leading to the accumulation of toxic by-products of fatty acid metabolism. L-carnitine supplementation revives fatty acid metabolism and restore normal mitochondrial function. But even this powerful improvement in cellular energy metabolism cannot up for the energy drain that comes from the loss of energy substrates caused by low oxygen delivery to the tissue. Only D-Ribose can do that.

 

D-Ribose:

Rebuilding the Cellular Energy Pool

As long as cells and tissues have plenty of oxygen, the pool of energy substrates in the cell remains high. And as long as there is enough L-carnitine and Coenzyme Q10 available, the process of energy utilization and supply can proceed unimpeded. However, the cellular supply of oxygen can be restricted by acute or chronic heart disease, peripheral vascular disease, any number of skeletal – or neuromuscular diseases, or even high-intensity exercise.

When cells are deprived of oxygen the mitochondrial energy turnover becomes inefficient. Remember, oxygen is required to let the oxidative pathway of energy recycling work properly. If the mitochondria are not able to recycle energy efficiently, cellular energy supply cannot keep pace with demand. But the cell has a continuing need for energy so it will use all its ATP stores and then break down the by-product, adenosine diphosphate (ADP), to pull the remaining energy out of this compound as well. What’s left is adenosine menophosphate (AMP). Since a growing concentration of AMP is incompatible with sustained cellular function it’s quickly broken apart and the by-products are washed out of the cell. The net result of this process is a depletion of the cellular pool of energy substrates. When the by-products of AMP catabolism are washed out of the cell, they are lost forever. It takes a long time to replace these lost energy substrates even if the cell is fully perfused with oxygen again.

Ribose is the only compound used by the body to refill this energy pool.  Every cell in the body has the capacity to make ribose, but hearts, muscles, and most other tissues lack the metabolic machinery to make ribose quickly when the cells are stressed by oxygen depletion or metabolic insufficiency.  Ribose is made naturally in the cells from glucose.  In stressed cells, however, glucose is preferentially metabolized for the energy turnover and is not available for ribose synthesis.  So when energy pools are drained from stressed cells, the cells must first wait for the slow process of ribose synthesis before they can begin to replace their lost energy stores.

    Acute ischemia, like that which takes place during a heart attack, heart surgery, or angioplasty, drains the cell of energy.  Even when oxygenated blood flow returns, refilling the energy pool may take ten or more days.  But when oxygen deprivation is chronic, or when energy metabolism is disrupted by disease, there may be so much continual strain on the energy supply that the pool can ever refill without the assistance of supplemental ribose.  Conditions like ischemic heart disease or congestive heart failure fall into this category.  In these situations, supplementing the tissue with exogenous ribose is the only way the cell can keep up with the energy drain.

 

Magnesium:

Switching on the Energy Enzymes

Magnesium is an essential mineral that's critical for energy requiring processes, in protein synthesis, membrane integrity, nervous tissue conduction, neuromuscular excitation, muscle contraction, hormone secretion, maintenance of vascular tone, and in intermediary metabolism.  Deficiency may lead to changes in neuromuscular, cardiovascular, immune, and hormonal function; Impaired energy metabolism; and reduced capacity for physical work.  Magnesium deficiency is now considered to contribute to many diseases, and the role for magnesium as a therapeutic agent is expanding.

    Magnesium deficiency reduces the activity of important enzymes used in energy metabolism.  Unless we have adequate levels of magnesium in our cells, the cellular processes of energy metabolism cannot function.  Small changes in magnesium levels can have a substantial effect on heart and blood vessel function.  While magnesium is found in most foods - particularly vegetables - deficiencies are increasing.  Softened water and a trend toward lower vegetable consumption are the culprits contributing to these rising deficiencies.

 

Supporting the Links in The Energy Cycle Chain – the Synergy

Clearly, each membrane of the “Awesome Foursome” is fundamental to cellular energy metabolism in its own right. Each plays a unique and vital role in supplying the heart with the energy it needs to preserve its contractile force. Each is independently effective in helping hearts work through the stress of disease. And while each contributes immeasurable to the energy health of the cell, in combination they are unbeatable. Allow me to reiterate the step-by-step, complicated cellular processes involved to be sure that you really understand the rationale for using these nutrients.

The cell needs a large, sustained, and healthy pool of energy to fuel all its metabolic functions. Contraction, relaxation, maintenance of cellular ion balance, and synthesis of macromolecules, like proteins, all require a high energy charge to carry their reactions to completion. The energy pool must be preserved, or these fundamental cellular functions will become inefficient or will cease to operate altogether. To keep the pool vibrant and healthy, the cell needs ribose. But even with supplemental ribose, the cell needs the efficient turnover of its energy stores to balance ongoing energy utilization with supply. That’s where CoQ10 and L-carnitine come into play.

The converse is also true. Even if the cell is fully charged with energy, cellular energy supply will not keep pace with demand if the mitochondria are not functioning properly. CoQ10 and L-carnitine work to keep mitochondrial operations running at peak efficiency, and one side cannot work effectively without the other. Even though CoQ10 and L-carnitine can make the energy turnover mechanisms work more efficiently, they cannot increase the cell’s chemical driving force, and their action will be only partially effective. Ribose on the other hand, can keep the energy pool supplied with substrate, but the value of energy pool repletion cannot be fully realized if the substrate cannot be maximally utilized and recycled. Ribose fills the tank; CoQ10 an L-carnitine help the engine run properly.

Magnesium is the glue that holds energy metabolism together. By turning on the enzymes that drive the metabolic reactions, magnesium allows it all to happen.

These four nutrients must be utilized by cardiologists and other physicians as they treat patients day-to-day. On my own journey, using Coenzymes Q10 for two decades, L-carnitine for more than ten years, D-Ribose for two years, and magnesium equally as long, I’ve seen this “Awesome Foursome” reduce suffering and improve the quality of life for thousands of patients.

The future of nutrition in conventional medicine is very bright, although the integration of nutritional supplements has been a slow and, at times, lonely process.

L-carnitine and Coenzyme Q10 are finally gaining the recognition they deserve. D-Ribose is emerging as a new player in the complex understanding of metabolic cardiology, and doctors are beginning to discuss the important role of magnesium deficiency in heart patients. As a practicing cardiologist for over thirty years, I see metabolic cardiology as the future for the treatment of heart disease and other complex disease conditions, as well.



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Complete Liver Cleanse
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Date: April 19, 2007 04:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Complete Liver Cleanse

Complete Liver Cleanse

Technical Data Sheet

 

DESCRIPTION:

The liver performs over 500 functions, including metabolizing carbohydrates and proteins, synthesizing and storing vitamins, and regulating hormones – naming just a few. To do this job, the liver is also required to be exposed to potentially harmful toxins and chemicals, every day.

One way to support the liver is through periodic supplementation with the proper balance of herbal ingredients, phytosterols, and fiber. Complete Liver Cleanse is a convenient, multi-ingredient formula that supports overall liver health and detoxification.

Complete Liver Cleanse:

Includes ingredients for various aspects of liver and gallbladder support:

-Herbal ingredients that support liver and gallbladder health

-Detoxifying ingredients that keep bound toxins from being reabsorbed

-Phytosterols to block cholesterol absorption in the intestines

-Fiber that moves cholesterol and toxins out of the body

-Oat beta-glucan fiber with up to 4 times higher viscosity than other beta-glucan

Fibers

-Simple, two week liver cleanse program

FORMULA:

Each 3 capsules contain:

Calcium (as calcium D-glucarate) 13 mg

Proprietary PuraFiber Blend: 1 mg

Viscofiber Oat B-Gucan Concentrate, phytosterols

(beta sitosterol, campesterol, stigmasterol, brassicasterol,

and other plant sterols), and glucomannan

Milk Thistle (Silybum marianum) Fruit Phytosome 220 mg

One part Milk Thistle Extract, standardized to contain 80%

Silymarin bound to two parts phosphatidylcholine (soy) using

a patented process

Burdock (Arctium lappa) Root Extract 4:1 100 mg

Calcium D-Glucarate 100 mg

Boldo (Peumus boldus) Leaf Extract 2:1 75 mg

Turmeric (Curcuma longa) Rhizome Extract 50 mg

Standardized to contain 90% curcuminoids

Dandelion (Taraxacum offinale) Root Extract 4:1 50 mg

Artichoke (Cynara scolymus) Leaf Extract 30 mg

Standardized to contain 13-18% caffeylquinic

Acids calculated as chlorogenic acid

Contains no: sugar, salt, yeast, wheat, dairy products, artificial coloring, artificial flavoring, ingredients of animal origin, or preservatives. This product contains natural ingredients; color variations are normal.

Other ingredients: See label for most current information

Viscofiber is a registered trademark of Cebena Bioproducts, Inc. The use and composition of the Viscofiber proprietary formula is protected by patients and patent applications filed in the U.S., Canada and internationally.

This product contains calcium D-glucarate, the use of which is licensed from Applied Food Sciences, LLC, and protected by U.S. patent 4,845,123.

HOW DOES IT WORK?

The Liver

Every day, the liver must process an almost unbelievable amount of blood – at a rate of three pints every minute. All the while, the liver performs over 500 physiologic functions, including protein and glucose synthesis, carbohydrate metabolism, vitamin and mineral storage, synthesis of clotting factors, urea formation, metabolism of medications, and the production of bile. The liver also assists in hormonal regulation, blood glucose control, and other regulatory functions.

Harmful substances that have been neutralized by the liver are carried to the intestines and kidneys for excretion. They are transported by bile, a greenish, watery solution that is synthesized, and continuously being excreted, by the liver. Stored in the gallbladder, a small sac cupped in the under surface of the liver, bile is also required for the digestion of dietary fats. However, in the case of toxins, bile is primarily an early transporter of the toxic compounds to the intestines, where they can be bound to fiber that helps transport them out of the body. Environmental toxins, including lipid (fat) soluble toxins, are broken into water-soluble components by bile to be excreted through the kidneys or colon.

Liver Detoxification

Detoxification refers to the process of excreting potentially harmful compounds that are both generated by the body and acquired through exposure to the environment. In the body, toxins are generated as by-products of cellular metabolic processes. Examples include dead and digested bacteria, hydrogen peroxide, cellular debris, and carbon dioxide.

The Environmental Protection Agency has determined that the amount of environmental toxins in the air, groundwater, and soil has increased significantly in the last 40 years. In fact, the use of pesticides has doubled every ten years since 1945. Americans are increasingly exposed to heavy metals, pesticides, fossil fuel emissions, sulfur oxides, hydrocarbons, and other harmful chemicals. The Environmental Protection Agency reports that traces of toxic chemicals can now be found in nearly every American.

Herbal Liver Support

One of the major components in Complete Liver Cleanse is its milk thistle extract, standardized to contain 80% silymarin, the plant’s most bioactive compound. Milk Thistle provides support, at a cellular level, for healthy liver function. A patented delivery system, known as the Phytosome process, provides superior absorption of the milk thistle extract.

Silymarin, a key compound found in milk thistle, is a mixture of flavonoids with a long history of liver support. Silymarin supports the health of Kupffer cells, specialized liver cells responsible for removing bacteria, old blood cells, and other foreign matter from the liver’s blood supply. Silymarin scavenges free radicals (superoxide anion radical and nitric oxide) produced by activated Kupffer cells, supports healthy leukotriene levels, and supports glutathione production that is used in detoxification.

Silymarin also supports the health of hepatocytes, highly versatile liver cells with unique physiologic functions. Studies of silymarin have demonstrated that it supports the health of the hepatocyte outer membrane, which is crucial to the liver’s detoxification processes. Silymarin also supports the healthy regenerative ability of the liver through support of protein synthesis in the hepatocytes.

Phytosome Process

A special, patented proves known as Phytosome enhances the absorption of milk thistle in Complete Liver Cleanse. The Phytosome process pairs herbal ingredients with phosphatidylcholine molecules. Phosphatidylcholine is a naturally occurring substance found in soybeans, egg yolks, and some vegetables. In the body, phosphatidylcholine is an important building block of cell membranes.

When milk thistle (or other herbs) are bound with phosphatidylcholine, the phosphatidylcholine molecule facilitates absorption through the intestines into the bloodstream. Research has shown increased blood and serum levels for phytosome herbs in comparison to the individual herb alone.

To test whether binding an herb with phosphatidylcholine increased its bioavailability, researchers gave volunteers identical amounts of either milk thistle alone, or milk thistle phytosome. The researchers then took blood sample from the participants and measured the level of silybin (a key compound in milk thistle). The measurements showed that silybin levels in participants taking the phytosome form of milk thistle were higher, and that silybin was detected for a longer time, than those who took milk thistle without the phytosome delivery system.

Other Herbal Liver Supportive Ingredients

Herbal extracts are often at their best when they are working synergistically – that is, when different constituents of each plant work together and support each other. Complete Liver Cleanse contains a variety of herbal extracts that have noted benefits for supporting the body’s healthy bile flow and free-radical scavenging effects. These ingredients provide a wide spectrum of liver supportive benefits.

For instance, dandelion root extract supports healthy bile flow from the gallbladder.

Burdock Root:

Burdock is originally native to Europe and Asia, but was introduced to North America, probably during colonial times. The plant is commonly found in the northern United States, and is very recognizable, with large, heart-shaped leaves. It has a long history of traditional use for gastrointestinal support.

Burdock root (Arctium lappa) supports the natural physiologic processes of organs involved in detoxification and elimination: notably, the liver, kidneys, and intestines.

Boldo:

Bolodo (pemus boldus) is a small evergreen native to South America, but naturalized to southern Europe. The leaves are considered the health supportive part of the plant. This herb has a long history of use in Chile, and became known in Western countries in the late 19th century.

In scientific studies, boldo appears to have strong free-radical scavenging ability, mostly attributed to the catechin and flavonoids content of its leaves. In a clinical study, boldo also appears to relax smooth muscle and support intestinal transit time.

Artichoke Leaf extract specifically supports healthy bile production in the liver and healthy gastrointestinal function in general. Research into artichoke’s gastrointestinal supportive properties has included at least three clinical trials. Artichoke’s role in supporting healthy cholesterol levels within normal limits has also been investigated.

Turmeric:

Turmeric (Curcuma longa) is a perennial shrub native to southern Asia with a long history as both a food ingredient and for health support.

More recently, turmeric has been investigated for its support of healthy bile secretion, and pancreatic and gastric function.

In a scientific study, dietary curcuminoids derived from turmeric supported healthy lipid metabolism and cholesterol levels already within normal limits.

Curcumin has also been shown in scientific studies to enhance the activity of glutathione S-transferase - an enzyme responsible for linking glutathione (one of the body’s natural antioxidants) with toxins to help remove them from the body. In this way, it provides additional support for healthy liver function.

Detoxification

Calcium d-glucarate:

The process of detoxification is the breakdown and excretion of substances that are no longer needed or may be harmful to the body. One of the ways in which the body excretes hormones and toxins is by binding them to glucuronic acid in the liver, and then excreting this compound in the bile.

However, this process can be disrupted by B-glucuronidase, an enzyme that is produced by intestinal bacteria. This enzyme has the ability to break (uncouple) the chemical bond established by glucuronic acid. This action releases the bound toxins, which are then reabsorbed into the body instead of being excreted.

Calcium D-Glucarate is the calcium salt of d-glucaric acid. It is found in both the human body, and in some plant sources, including broccoli and oranges.

Calcium d0glucarate enhances the body’s detoxification systems by inhibiting the actions of beta-glucuronidase. This helps decrease the portion of active compounds that could be hazardous to the body.

Phytosterols

Cholesterol is a waxy, fat-like substance that is vital to fat digestion, cell structure, nerve insulation and hormone production. Cholesterol comes from two sources: dietary or “exogenous” cholesterol absorbed in the intestine, and “endogenous” cholesterol formed mostly by the liver and stored in the gallbladder.

Cholesterol occurs in two forms known as lipoproteins. Lipoproteins act as transports that carry fat s to and from the cells.

High-density lipoprotein (HDL) carries low lipid density cholesterol (LDL) away from arterial walls and returns it to the bloodstream. LDL then travels back to the liver, which processes and eliminates it. While high levels of HDL cholesterol is desirable, high amounts of LDL cholesterol is not supportive of optimal health.

LDL-cholesterol is both synthesized in the body, or absorbed into the bloodstream through receptor sites in the intestines. Think of these receptors as “parking spaces” for cholesterol. As it happens, the liver can receive up to 500 mg per day of cholesterol from intestinal absorption. (It can also produce as much as 1000 mg per day).

One way to help reduce the absorption of LDL cholesterol molecules it to occupy their “parking places” in the intestines. Phytosterols in Liver Cleanse are essentially the “fat” of plants. They’re found in nuts, corn and rice and are some of the “good” fats associated with the benefits of olive oil, flaxseed oil and other healthy oils.

The structure of phytosterols is so similar to cholesterol that they fit perfectly in the specially-shaped intestinal parking spaces that LDL-cholesterol would normally occupy.

Taken with, or just before meals, phytosterols block the cholesterol receptor sites so that cholesterol is excreted from the body rather than absorbed. Phytosterols also have the additional role of helping promote healthy bile salt excretion in the intestines.

The phytosterol blend in Complete Liver Cleanse can help minimize the absorption of cholesterol from high-protein food sources, help retain healthy cholesterol levels that are within normal limits, and move bile sat through the digestive system.

Fiber and detoxification

Fiber plays a key role in the removal and excretion of intestinal toxins in detoxification. Only fibers that can effectively bind toxins will be successful in eliminating these harmful substances. Due to the unique benefits of individual fibers, the best binding, removal, and elimination effects are noted when combining different fiber types. Complete Liver Cleanse contains a combination of oat beta-glucan and konjac fiber that has been shown in scientific studies to bind to bile salts.

Dietary fibers are complex mixtures of cellulose, hemicellulose, pectin, mucilage, and gums, which are resistant to digestive fluids or enzymes – that is, they aren’t absorbed into the bloodstream. So, while fiber itself doesn’t necessarily provide nutrients, it does promote laxation and modulate gastric and intestinal physiology. Intestinal flora that normally reside within the colon utilize fiber as a medium for microbial fermentation, resulting in the synthesis of the vitamins, vitamin K and biotin, and the formation of short chain fatty acids, or SCFA.

SCFA have a simple, but important job: to be absorbed by the colon mucosa, increasing fecal matter bulk and providing energy. Fiber has been demonstrated in numerous clinical studies to provide support of gastrointestinal, cardiovascular, immune, and endocrine function health.

Complete Liver Cleanse also features two unique fibers to promote detoxification – konjac and oat beta-glucan.

Konjac:

Konjac, (Amorphophallus Konjac) is a tuber native to Asia, rich in glucomannan polysaccharide. This viscous material is made into a jelly, noodles and other foods. It has been used in Japan for at least a thousand years.

As a fiber, konjac has shown positive results maintaining healthy cholesterol levels within normal limits in clinical studies. This beneficial effect is due to konjac’s ability to boost excretion of bile acid.

Oat beta-glucan:

Oat beta-glucan has been a widely studied fiber source for supporting healthy cholesterol levels within normal limits.

In a randomized clinical study, oat beta-glucan showed support of healthy HDL/LDL ratios already within normal limits in individuals over a three week trial.

Closely linked to cholesterol, oat beta-glucan has also been studied for its support of healthy bile excretion.

Fiber has benefits beyond maintaining healthy cholesterol levels already within normal limits. It also contributes to healthy blood sugar levels already within normal limits. In a double-blind, clinical study, the oat beta-glucan fiber used in Liver Cleanse was shown to have 4 times higher viscosity than another high concentrate beta-glucan fiber.

Viscosity – the resistance to flow – is an important factor in beta-glucan, and all fiber. Water, for instance, would have a low viscosity, because it provides very little resistance to movement. Fiber, on the other hand, should have a higher viscosity in order to maximize its transit time through the GI tract, providing a gentle “scrubbing” on the intestinal walls. Therefore, the higher the viscosity, the greater the potential benefit.

RECOMMENDATIONS:

Three capsules in the morning and three capsules at bedtime for 14 days.

LABEL PRECAUTION:

Warnings: Do not use if you know or suspect you have an obstructed bile duct or problematic gallstones. If pregnant, nursing or taking prescription drugs, consult your healthcare practitioner prior to use. Keep out of reach of children.



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Supplements good for reducing stress and boosting energy!
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Date: March 26, 2007 02:05 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Supplements good for reducing stress and boosting energy!

Vitality 101

 

More and more Americans are feeling overworked, overtired, and overcome by life’s demands. We just do not have the energy we need to meet our responsibilities to the people we care about. More importantly, we don’t even have the energy to have fun! It seems that a constant feeling of fatigue has become part of the American way of life.

Research has shown that the same processes that cause lack of energy can rob us of sleep, saddle us with excess weight, disrupt our hormonal balance, and create significant amounts of stress in our daily lives. Chronic stress can dramatically contribute to fatigue, sleep disorders, irritability, and anxiety. The research simply confirms what most of us already know – uncomfortable stress can really wear us out mentally and physically! It can take away the satisfaction of a job well done. It can take away our ability to believe in ourselves. And, sadly and maybe most importantly, continual stress can take the fun and joy out of life.

In a separate issue of Ask the Doctor, we discuss the energy and sleeping needs of people suffering from chronic fatigue syndrome and fibromyalgia. In this issue, I discuss the 3-step process I call “Vitality 101.” People do not have to accept pain, insomnia, or fatigue. It’s time for everyone to feel great and have a life they love!

 

Step 1 – Nutrition

Good overall nutrition is important for everyone! As a foundation product to support energy levels, a powdered drink mix is a pleasant, easy way to ensure that you are taking all of the necessary vitamins, minerals, and amino acids that you need to have great energy all through your day.

The following chart lists the most critical ingredients. You can see that almost all of the vitamins and minerals work together to help improve energy levels and overall health.

Nutrients

Effect on Vitality & Energy

Vitamin A

Essential for healthy skin and mucous membrane integrity, healthy immune system responses and healthy bone growth and healthy reproductive processes. Vitamin A in the form of beta-carotene is an antioxidant and free radical fighter.

Vitamin C

Necessary for the proper functioning of the immune system. Antioxidant, free radical fighter. Assists with hormone synthesis; supports healthy skin integrity; supports healthy iron absorption.

Vitamin D

Essential for healthy calcium and phosphorus metabolism, and the absorption of vitamin A; supports bone mineralization.

Vitamin E

Helps oxygen circulation; supports healthy nerve transmissions; supports healthy leg nerves and muscles; helps boost energy levels.

Magnesium

Supports enzyme activity involved in energy production; supports healthy nerve and muscle function; supports healthy immune system functions

Malic Acid

Catalyst to stimulate the complete burning of fuel for energy; supports healthy connective tissue and muscle functioning.

Betaine

Works with B vitamins to synthesize amino acids, and acts as a precursor to SAM-e. SAM-e (S-adenosylmethionine) is a naturally-occurring molecule in the body, and may have an effect on overall mood elevation

Selenium

Works with vitamin E to maintain healthy cell membranes; supports healthy thyroid functioning.

Zinc

Supports healthy immune system, healthy enzyme processes and healthy immune response.

Amino Acids

Glycine, Serine, Taurine, Tyrosine are essential for the production of energy in the body. Also essential for brain function.

Fructooligosaccharides

Provides nutrition for good bacteria in the intestinal tract, improving digestion and healthy microflora.

In addition to the powdered energy drink mix, it is important that you also take a high potency vitamin B-complex supplement. This should include niacinamide, thiamin, riboflavin, vitamin B6, vitamin B12, pantothenic acid, and choline, which are especially important to restore the energy production needs of your body. It is also critical to get enough water, as most Americans are chronically dehydrated.

 

B Vitamins

Effect on Vitality & Energy

Thiamine B1

Supports healthy energy, growth, appetite, and learning capacity; healthy red blood cell production; carbohydrate metabolism and the production of hydrochloric acid.

Riboflavin B2

Riboflavin (vitamin B2) is crucial in the production of body energy. Supports healthy glutathione reductase activity, which helps maintain glutathione, a major protector against free radical damage. Vitamin B2 itself also has antioxidant qualities.

Niacinamide B3

Niacinamide is an essential nutrient for the healthy metabolism of carbohydrates, fats, and proteins, as well as for the production of hydrochloric acid for digestion.

Pantothenic Acid B5

An essential component in the production of coenzyme A, a vital catalyst that is required for the conversion of carbohydrates, fats, and protein into energy.

Pyridoxine HCL B6

Aids in the conversion of amino acids to carbohydrate or fat for storage or energy. Also required for the production of serotonin, melatonin, and dopamine. Since it aids in the formation of several neurotransmitters it is an essential nutrient in the regulation of mental processes.

Vitamin B12

An essential nutrient for healthy energy production. Vitamin B12 helps support metabolism of carbohydrates and fats. It contributes to healthy cell formation and cellular longevity.

Folic Acid

Folic acid promotes energy production and supports the immune and nervous systems. Folic acid works best when combined with vitamin B12. Recent research shows folic acid can reduce the amount of the amino acid homocysteine in the blood.

 

Step 2 – Rest Your Body

Having trouble sleeping is one of the most troubling symptoms of stress. While the stress is wearing us down and making us tired, it’s also keeping us tense and unable tot relax. The result? That easy drift into sleep becomes harder and harder. And if we are lucky enough to actually get some shut-eye, stress will often wake us up, sometimes several times a night.

This occurs because excess stress suppresses the sleep center in the brain. It is important to break the “stress/insomnia cycle” early, before it results in pain and hormonal and immune dysfunction!

Because good quality sleep is how the body repairs and re-energizes itself, it may be helpful to use herbal products to promote good quality sleep. There are many natural supplements that are marketed as sleep formulas. To get the best results, it is very important that the right ingredients are in the sleep formula you buy. Look for a supplement that has a blend of herbs that promote deep sleep, such as valerian, L-theanine, hops, passionflower, Jamaica dogwood and wild lettuce. This combination of herbs is important as each herb addresses a different aspect of sleeplessness and muscle tension caused by stress. Taking only one or two of these herbs alone is much less likely to be effective.

 

Ingredients

Effect on Sleep

Wild Lettuce

Has been found to have sedative effects.

Hops

Acts as a mild sedative and has a sleep inducing effect.

Jamaica Dogwood

Has been found to be mildly sedative and is often used for anxiousness.

L-Theanine

Causes significant increases of neurotransmitter concentrations in the brain, which promotes muscle relaxation and improves sleep.

Valerian

This herb has been clinically studied for its ability to improve sleep quality.

Passionflower

This herb eases nervousness and insomnia.

 

Step 3 – Manage Excess Stress Levels

In this fast paced world, it is important to learn to manage the stressor in our lives. Glandular extracts, such as raw adrenal extract, can offer natural support to help our bodies deal with the effects of stress and, in turn, can boost your energy levels. Exercise is another stress buster. Using your body physically is important for good health. Find something that is fun for you, however, or you are unlikely to stick with it!

 

Q. Does stress zap my energy in any other ways besides making me lay awake at night and causing me to be a zombie the next morning?

A. Most people are familiar with the body’s dramatic response to an emergency. The heart pounds, the muscles constrict, and the lungs expand – and while this is happening, we are capable of greater than normal strength and speed. This response is the body’s way of rescuing itself when faced with an emergency. We don’t have to think about it to make it happen. It’s automatic.

The same can be said of a chronic stress response. Whether we’re late for a business meeting because we’re stuck in traffic, or worrying about how we are going to pay for our children’s college tuition, our response to stress happens automatically. The difference between the two is that the body’s response in an emergency starts and resolves itself quickly. The response to being stuck in traffic may not.

The body makes the “stress hormone”, cortisol, to handle the normal stresses of day-to-day living. But in an emergency situation, the adrenal glands, located above the kidneys, secrete increased amounts of this hormone until the emergency passes. Then the body returns to its normal function. Unfortunately, however, chronic stress is more complex. When our body is subjected to increased amounts of the hormone, cortisol, for an extended time, it can lead to a condition known as “adrenal burnout” or “adrenal fatigue.” While it’s true that very large amounts of cortisol can have damaging effects on our hormones, too little cortisol doesn’t allow us to respond to stress properly. It’s really a matter of balance.

 

Q. How can I control the stress in my life and re-energize?

A. Many people who are under constant stress may have adrenal burnout. Adrenal burnout occurs when the adrenal glands are constantly producing cortisol in response to chronic stress. Over time, this exhausts the adrenal reserve, meaning the adrenal gland can no longer increase cortisol production in response to stress.

The good news is that changes in our hormone levels can return to normal when stress is decreased. The key in learning how to deal with daily stress is to allow the body to return to its normal state. I discuss additional techniques for coping with stress in my recent book Three Steps to Happiness! Healing Through Joy (see my website, www. jacobeitelbaum .com, for more information). In addition to stress control, it is important to supplement your adrenals with a glandular therapy regimen to ensure healthy cortisol levels and adrenal function. Glandular therapy, which uses the concentrated forms of bovine (cow) or porcine (pig) glands, can improve the health of our glands. Pioneers in the field of endocrinology (the study of hormones) hypothesized that glandular extracts work by providing nutrients the body lacked and thus repaired the malfunctioning gland.

 

Adrenal Extract

If you are one of the unlucky folks with stressed-out adrenal glands, you should see great results from taking raw adrenal supplements. Be sure to buy adrenal extract supplement that contains both whole adrenal and cortex adrenal.

 

The best adrenal supplement should also contain vitamin C, vitamin B6, pantothenic acid and licorice. Licorice contains glycyrrhizin, which is broken down into glycyrrhizic or glycyrrhetinic acid. This compound inhibits the activity of an enzyme that turns active cortisol into inactive cortisol. While in high amounts (greater than 100 mg of glycyrrhizic acid/day), licorice administration causes hypertension, no such effects have been observed at lower doses. Experts have speculated that inhibition of the cortisol-converting enzyme may reduce cortisol-related symptoms associated with adrenal insufficiency. The adrenal glands use these nutrients to manufacture cortisone and other compounds. It just makes sense to purchase an adrenal supplement with these supportive ingredients.

 

Ingredients

Effect on Stress

Adrenal Polypeptide Fractions & Adrenal Cortex Extract

Polypeptide fractions are easily digested and help support the thyroid and the adrenal gland to regulate levels of cortisol and other hormones.

Vitamin C

Provides extra support during periods of chronic stress.

Vitamin B6

Required to make serotonin, melatonin and dopamine – all vital for maintaining energy levels – very important in dealing with stress-filled lifestyles.

L-Tyrosine

L-tyrosine is an amino acid that supports nerve transmission and healthy adrenal, thyroid and pituitary glands. Converts to epinephrine and norepinephrine, brain neurotransmitters crucial during times of stress.

Licorice

The component of licorice called glycyrrhizin, which breaks down into glycyrrhizic acid. This compound inhibits the breakdown of cortisol produced by the body, helping balance this important hormone. Glycyrrhizic acid’s mechanism of action is through the inhibition of 11-beta-hydroxysteroid dehydrogenase. This enzyme catalyzes the conversion of cortisol to cortisone. It also inhibits the metabolism of corticol, and minimizes the binding of cortisol to mineral corticoid receptors.

 

Liver Extract

Did your grandmother ever tell you to eat your liver so that you didn’t get “tired blood?” Well, it turns out that she was right. Liver extract is another glandular extract that can help improve energy levels.

Liver extract is an excellent source of highly bioavailable nutrients including iron, B vitamins (especially B12), and other minerals. The stamina and energy-enhancing benefits of liver are widely touted. Liver extract has been shown to support healthy function of the liver and increase the energy levels inside our body.

Because heat will destroy the key components in the liver, a high quality liver extract supplement should be cold-processed and encapsulated to enhance speed and absorption of nutrients from liver. A high quality aqueous liver extract supplement should also contain vitamin B12 to support healthy blood iron and oxygen levels to energize.

Ingredients

Effect on Stress

Liver Fractions

Liver extract may have anti-vital properties and increase the mitochondrial production of adenosine triphosphate (ATP). ATP is an important carrier of energy in the cells.

Vitamin B12

B12 is necessary for the production of red blood cells and healthy blood oxygen levels.

 

Q. It will be great to get a good night’s sleep. Are there also any other natural alternatives that could help promote relaxation and increase my energy levels during the day?

A. Yes, there are. Rhodiola rosea is an all-natural herb that has long been used to help relieve stress and increase energy. Rhodiola has also been used to lift our moods, improve sexual satisfaction, and even help in certain nervous system disorders. First used in Siberia and Russia, Rhodiola is now being extensively studied and has been found to increase resistance to toxins (both physical and chemical), balance the work of the body, help memory storage and mental functioning, and improve resistance to physical and emotional stress.

In clinical trials, the most effective Rhodiola rosea extract was found to contain 3% rosavins and 1% salidroside. While there are many Rhodiola supplements in health food stores, only those containing these specific amounts can provide the best results.

 

Lifestyle Treatments

Altered digestion, food intolerances, decreased energy, fatigue, cognitive problems, and sleeplessness create the need for changes in daily living routines. These can include alterations in diet; exercise modifications; alterations in activities of daily living according to one’s energy level; and sleep/rest management. All may require the assistance of a professional clinician, such as a chiropractor, nutrition specialist, physical and/or occupational therapist, mental health professional, or sleep therapist.

 

Conclusion

Super busy lives demand super strength nutrition. Begin each day with a powdered nutritional supplement after getting at least 8 hours of sleep each night. In addition to the nutritional beverage mix, a vitamin B complex supplement should be taken every morning. The nutritional drink mix and the vitamin B complex supplement will ensure that your body has all the vitamins, minerals, amino acids, and other nutrients to combat your fatigue. Taking a daily adrenal supplement, like the one discussed earlier, will provide the much needed (and often depleted) nutrients your body may be lacking, and help you recover lost energy. Rhodiola rosea, and ginseng can offer additional natural nutritional support in your busy life to boost your energy levels. These nutritional supplements can be used daily and you will feel energized to get through each day’s challenges and opportunities!



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The Important Role of Nutritional Magnesium & Calcium Balance in Humans Living with Stress
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Date: August 23, 2006 03:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Important Role of Nutritional Magnesium & Calcium Balance in Humans Living with Stress

 

Part I. The Stress Response

The stress reaction is a host of responses necessary for any animal to live in the world.  Commonly called the fight-or-flight reation,  we as humans often experience it in rapid heartbeat and increased breathing rate.  It comes when we exercise more vigorously than usual, or when we are suddenly and unexpectedly frightened.

We are all different.  We show a range in how strongly we experience the stress response.  Most of us are usually calm and experience the stress response when an unexpected noise frightens us to alertness, or we run to first base as fast as we can in a benefit baseball game that is not on our usual playtime schedule.  We breathe harder for a while and notice our hearts beating faster and harder then usual, but after a while these responses all calm down, and we are again in our usual state—out or the stress response.  Others of us are very low key, and it takes a lot to disturb our physiological calm.  Still others of us are very sensitive to triggers of the stress response and go into it “at the drop of a hat” and to a greater degree than do calmer people.  For some, parts of the stress response are almost always engaged—never really calming down all the way—giving one a hyper-vigilant or anxious demeanor.

When a stress trigger occurs, the body puts out stress hormones, magnesium and calcium, among other things, into the bloodstream.  At the same time, nerve cells begin to “fire,” telling heart and muscles to “speed up. NOW!!!”  These blood, nerve and organ changes make possible the instantaneous and collective rise in the body’s heart rate, blood pressure, and other necessities for the fight-or-flight reaction.

Much research has been done on the stress response, especially on the effects of stress hormones, such as adrenaline (also called epinephrine) on body, organ and cell.  You can get an idea of how widespread the stress response is-affecting every aspect of physiology—by noting some of the reactions to adrenaline, one of the major stress hormones.  See Table 1.

Table 1

The effects of Adrenaline: Adrenaline (also called epinephrine) is one of the body’s major stress hormones.  When adrenaline is released into the bloodstream, it has simultaneous, rapid, and widespread effects on the body. These include:

  • Widespread effects on circulation, muscles and sugar metabolism
  • Raised heart rate
  • Increased heart output
  • Increased rate and depth of breathing
  • Increased metabolic rate
  • Increased force of muscular contraction
  • Delayed muscular fatigue
  • Reduced blood flow to bladder (muscular walls relax and sphincters contract)
  • Reduced blood flow to intestines
  • Increased blood pressure
  • Increased sugar (glucose) in the blood
  • Increased breakdown of glucose for energy*, especially in muscle cells
  • Increased free fatty acids in the blood*
  • More oxidation of fatty acids to produce energy*
  • More ATP (the cells’ primary energy compound) produced*
  • Blood vessels constrict

 

*needs magnesium

 

Much study as the cellular, biochemical and physiological levels has shown that the stress response vitally involves the influx of calcium into cells,  resulting in a drastic change in the cells’ internal magnesium-to-calcium ratio (Mg:Ca).

In simple solutions, such as salt water, all ions are evenly dispersed.  Not so in living cells.  Ions are carefully and meticulously separated in living cells, and this ion “packaging” is vital to life processes and health.  Calcium ions, for the most part, are kept outside cells while magnesium ions are kept mainly inside cells.  The stress response changes this.  During stress response, calcium ions rush inside the cell, and this alters the internal Mg:Ca ratio.  This change in ratio exhibits wide effects because, while magnesium and calcium are very similar in their chemistry, biologically these two elements function and react very differently.  Magnesium and calcium are two sides of a physiological coin: they are antagonistic to one another yet comes as a team. For example:

  • Calcium excites nerves; magnesium calms them down. 
  • Calcium makes muscles contract, but magnesium is necessary for muscles to relax.
  • Calcium is necessary to the clotting reaction—so necessary for wound healing—but magnesium keeps the blood flowing freely and prevents abnormal thickening when clotting reactions would be dangerous.

Scientific study shows more and more that the underlying cellular change enabling the stress response is a low Mg:Ca ratio caused by a large and sudden influx of calcium into cells.  This stress response subsides when the cell’s magnesium returns to its dominant presence inside cells, moving extra calcium back outside cells to its “normal” Mg:Ca ratio.  This underlying principle is present in studies of nerve cell-stress hormone response, organs such as hearts, the high blood pressure response to stress, and the blood-clotting reaction during stress, among many others.  See Table 2.

 

Table 2

Magnesium and calcium are an “antagonistic” team in the fight-or-flight reaction.

Function

Calcium’s influence

Magnesium’s influence

Blood cell clumping

(platelet aggregation)

Activates

Inhibits

Other blood-clotting reactions

Encourages

Discourages

Nerve excitation

Enhances

Discourages

Adrenaline secretion

Enhances

Decreases

Adrenaline response

Enhances

Decreases

Blood vessel contraction

Increases

Decreases

 

“During stress response, calcium ions rush inside the cell, and this alters the internal Mg:Ca ratio.  This change in ratio exhibits wide effects because, while magnesium and calcium are very similar in their chemistry, biologically these two elements function and react very differently.  Magnesium and calcium are two sides of a physiological coin: they are antagonistic to one another yet come as a team.”

 

In the normal healthy state, the stress response occurs when necessary, and subsides when the crisis or trigger is over.  Since magnesium and calcium—two essential nutrients that must be obtained by the body from its dietary environment—are so essential to this important response, it is not surprising that nutritional magnesium and calcium status can affect the response. 

 

Let’s see how.

In the normal unstressed state, cellular Mg:Ca ratio is high.  If this cannot be maintained due to lack of adequate body magnesium or an overwhelming amount of body calcium, the ratio may not be able to maintain or return itself to its healthy nonstressed ratio.  In such a case, the stress response, in the absence of an appropriate trigger, can occur.  This can be seen when nutritional magnesium deficits cause high blood pressure or increase blood stickiness (platelet aggregation). Additionally, since a low Mg:Ca ratio can increase adrenaline secretion as well as cells’ response to adrenaline, a too low magnesium state can keep the stress response from subsiding in a timely way.  Even worse, when body magnesium becomes drastically low, this becomes a stress trigger in itself, alarming the body into further stress response with out enough magnesium to back it up, resulting in a low magnesium-high stress crisis that can end in sudden death.

In the industrialized world, we live in a state of chronic, on-going stress.  This environmental reality increases our daily need for magnesium in order to maintain a healthy stress response that can calm when not necessary.

 

Part II. Heart Disease Is Often a Magnesium Deficiency

Clearly, an adequate amount of nutritional magnesium—in proper balance with adequate nutritional calcium—is key to a healthy stress response.  And yet today we have diets dangerously low in magnesium.  Add the recent additions of nutritional calcium via supplements and food fortifications meant to stave off osteoporosis, and many of us are getting inadequate magnesium plus too much calcium.  This results in a large occurrence of heart disease.

Not all, but much of the heart disease in the industrialized world can be explained by the low magnesium state of these societies.  People with heart disease—for the most part—are people who are in a state of magnesium that is borderline or deficient.  Many studies on heart disease patients exist due to medicine’s effort to understand and treat this widespread malady.  Although not intended as such, this body of research shows us what stress can do to a person in a magnesium deficient state.

 

Part III. Mental and Emotional Stress Deplete Magnesium

It is commonly accepted that certain traditional risk factors for heart disease exist.  This include high cholesterol, high blood pressure, family history of heart disease, and other factors, all of which can be linked to a shortage of nutritional magnesium.  Recent studies tell us that stresses—both sudden and chronic—with their high magnesium requirements, are also strong risk factors for heart disease.

The sudden stress of the L.A. earthquake and the 9/11 World Trade Center attack showed an upsurge of adverse heart events in people with heart disease.  Even heart patients living in Florida, hundres of miles away from the WTC attack, showed more adverse heart events in response to 9/11 than in usual times.  Again, adverse heart events in this largely magnesium deficient population show that the triggered stress response tested their magnesium status and found it wanting.

Emotional stress and phobic anxiety cause heart problems in patients with heart disease—a population we know to be mostly low in their nutritional magnesium status.  Chronic states of emotional stress, including a history of childhood abuse, neglect or family dysfunction, depression, and panic disorder, must now be added to the list of traditional risk factors for heart disease such as high blood pressure and high cholesterol.  Depression can be a symptom of low magnesium status.  So can anxiety, panic attacks, irritability, hyperactivity, and over-sensitivity to loud noises.  Do these newly found risk factors cause heart disease, or are they risk factors because the, as well as heart disease, can all be aspects of low magnesium status?  These chronic sources of stress can increase the human need for magnesium as well as be caused by its deficit.

Emotional stress triggers in susceptible people can even bring a sudden death due to heart attack, presumably by initiating a stress/low-magnesium crisis.  Such emotional “triggers” include work stress, high-pressure deadlines, social isolation and loneliness, low socioeconomic status, anxiety, war, fear of war, anger and rage.  Identical stress triggers cause more human heart attacks regardless of age, race, gender, or geographic location, including continent.

Mental stress, such as working out a math problem, can be shown to have impact upon the magnesium-stress response connection, since it can bring on heart attacks in people with heart disease.

“Recent studies tell us that stresses-both sudden and chronic—with their high magnesium requirements, are also strong risk factors for heart disease.”

 

Part IV. Stress, Magnesium and Aging

We are hearing a lot about stress in the health media, and rightly so as this constant companion to our lives brings on the fight-or-flight syndrome, a stress response that, when activated, has been shown to shorten lifespan.  When we realize that the stress response is exacerbated when we are low in magnesium, that we are living on low-magnesium foods for the most part, and that our lifestyles are more and more filled with chronic stresses and stressful events, we are not surprised to see that several aspects of magnesium deficiency are remarkably like aspects of the aging process.

When faced with out stressful lifestyles, coupled with a society presenting a chronically low-magnesium/high-calcium diet, what is our best defense? For many of us, magnesium supplements can help to preserve or restore a healthy Mg:Ca balance, so important to our health in these stressful times.

 

 



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The unique clinical benefits of Sun Chlorella
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Date: March 25, 2006 12:34 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The unique clinical benefits of Sun Chlorella

Over the years, Sun Chlorella Corporation has been sponsoring true clinical trials, carefully designed and carried out according to current conventional methodologies used in the pharmaceutical industry for drug development and testing. These “double-blind” clinical trial studies have greatly contributed to the substantiation of why Chlorella pyrenoidosa is so widely recognized within the scientific, alternative, and medical communities. With documented positive findings that have been discovered through ongoing research, you can be sure you’re getting the best top quality products with Sun Chlorella.

Unique Clinical benefits.

According to human immunology expert Randall E. merchant, PH.D. of Virginia Commonwealth University, in Richmond, Virginia, Sun Chlorella and Wakasa Gold (Liquid Chlorella) may be helpful to those suffering from a number of serious health problems because of the many unique clinical benefits found naturally in this supper food. Dr. Merchant states that many who suffer from chronic illnesses, “are known to have nutritional deficiencies…and when proper nutrition returns, some of the symptoms and problems dissipate. Such individuals can benefit from the superlative nutritional powers of Sun chlorella.” The four principal components of Chlorella pyrenoidosa that have been shown to have certain health benefits include chlorophyll, the fibrous cell wall, beta-carotene, and the powerful chlorella growth factor (CGF).

Some of the clinical investigations completed by Dr. Randall E. Merchant and a team of physicians at the university have included fibromyalgia, ulcerative colitis, and hypertension. Their primary focus was on the potential benefit of dietary supplementation with Chlorella Pyrenoidosa to help improve quality of life, and normalize body functions in patients with these types of chronic illnesses. All the subjects in each of the clinical studies suffering from either fibromyalgia, ulcerative colitis, or hypertension, consumed 10 grams of chlorella pyrenoidosa in tablet form and 100 ml of liquid chlorella every day for two to three months.

Chlorella – Excellent for Everyone

Dietary supplementation with Chlorella pyrenoidosa has had a beneficial effect in many of the people who participated in the individual clinical trial studies. Dr. Merchant’s research suggested that adding Chlorella pyrenoidosa (a natural whole food) to the diet, rather than relying solely on pharmaceutical drugs may be extremely beneficial to those who are dealing with serious health issues, and those who want to stay healthy.

Everyone – young and old, healthy and ill – can benefit from Sun Chlorella’s purification abilities, natural defense protection, and wholesome nutrition. Sun Chlorella does so by purifying, nourishing, and protecting your body so your own natural defenses are able to work more efficiently. This is clearly a super food that should be a part of everyone’s diet.

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Astaxanthin - PHYTONUTRIENT ANTIOXIDANT
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Date: December 28, 2005 10:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Astaxanthin - PHYTONUTRIENT ANTIOXIDANT

"PHYTONUTRIENT ANTIOXIDANT" Astaxanthin

  • Potent Natural Antioxidant
  • More Powerful Than Vitamin E And Other Carotenoids
  • Supports Healthy Immune and Cardiovascular Function
  • Well-Researched With Documented Results
  • High Quality BioAstin® Astaxanthin

Carotenoids are a class of lipid-soluble natural pigments found in plants, as well as in phytoplankton and certain fungi and bacteria. The red, orange and yellow colors seen in fruits and vegetables are from carotenoids. When various aquatic animals such as salmon and shrimp eat plants containing some of the over 700 compounds that make up the carotenoid class, those animals are also decorated with the same brilliant colors. However, carotenoids do more than provide color - they’re powerful phytonutrient antioxidants. Beta carotene, lutein, and lycopene are some of the more well-known carotenoids, but the most powerful found to date is astaxanthin.

Astaxanthin is a fat-soluble carotenoid with a unique molecular structure that makes it an extremely effective antioxidant. The PDR® Medical Dictionary 2nd Edition defines an antioxidant as, “An agent that inhibits oxidation; any of numerous chemical substances, including certain natural body products and nutrients, that can neutralize the oxidant effect of free radicals and other substances.” Not only is astaxanthin a potent free radical scavenger, but it also can protect against oxidation, which limits the number of free radicals produced. Additionally, it’s very effective at quenching a molecule called singlet oxygen, a harmful reactive oxygen species formed through normal biological processes. Singlet oxygen possesses a high amount of excess energy that must be released to keep it from damaging other cells. Astaxanthin absorbs this energy and dissipates it as heat, and in the process returns the singlet oxygen to a grounded state.

A growing body of research is showing that astaxanthin is the creme de la creme of phytonutrient antioxidants. Studies comparing astaxanthin to other carotenoids have shown it to possess antioxidant activity up to 10 times stronger than that of beta carotene, canthaxanthin, lutein and zeaxanthin.4 A study published in 1990 conducted by Kurashige and associates compared the effectiveness of vitamin E and astaxanthin for the prevention of lipid peroxidation. The results showed that astaxanthin is 100-500 times more effective in preventing lipid peroxidation in vivo than vitamin E.5

Astaxanthin in algae provides protection against the effects of ultraviolet (UV) light exposure, and studies are showing that this protective effect is also imparted with dietary astaxanthin. Scientists believe that astaxanthin effectively scavenges the oxygen radicals produced through photo-oxidation caused by UV exposure. A 1995 study by Savoure and associates studied the protective effects of astaxanthin, beta carotene and retinol against UVinduced photo-oxidative stress. The results showed that astaxanthin is extremely effective in preventing increases of certain polyamines created through photo-oxidation, which damages skin. A particular polyamine was found to increase only 1.5-fold in subjects fed astaxanthin, whereas subjects in the control group experienced a significant 4.1- fold increase. It was concluded that astaxanthin works through a particular enzyme, increasing this enzyme’s consumption of polyamines in response to irradiation.

Research has shown that astaxanthin also offers cardioprotective effects through its ability to decrease oxidation of HDL (“good” cholesterol), which is a cholesterol transporter in the blood. It‘s well established that high levels of HDL and low levels of LDL (“bad” cholesterol) are desirable for healthy cardiovascular function, so protecting HDL from oxidation means there’s more circulating in the bloodstream. In a 1992 study by Murillo, subjects were fed dietary astaxanthin for 30 days. HDL cholesterol increased 57mg/dL, compared to the control diet (42.4 mg/dL). LDL cholesterol decreased from 12.5 mg/dL to 9.6 mg/dL. Clearly, astaxanthin exhibited an influence on the ratio of these two lipoproteins.

We can thank the lobster for the discovery of astaxanthin. Researchers working with an extract of the lobster Homarus astacus first characterized astaxanthin in 1938. It was soon discovered that astaxanthin is abundant in nature, although mostly in very low concentrations. The greatest source found is in green algae called Haematococcus pluvialis, which also contains other carotenoids such as beta carotene and lutein. NOW® Foods Astaxanthin supplies 4mg of this effective phytonutrient antioxidant and is an excellent source of this outstanding member of the carotenoid family. The astaxanthin used for our product is BioAstin® supplied by the Cyanotech Corporation, one of the premier suppliers of highquality astaxanthin taken from Haematococcus pluvialis, the richest natural source discovered. In addition to Astaxanthin, NOW® offers other carotenoids, including Lutein, Beta Carotene and Lycopene. Research continues to support the inclusion of carotenoids in the diet to support overall health. This is even truer for those with less than perfect diets and for those who smoke or spend any time with someone who does.

References
1) Hawkins, E.B.; Astaxanthin and Oxidative Stress; Natural Pharmacy, October 2003, pp. 20-21
2) Lorenz, R.T.; Astaxanthin, Nature’s Super Carotenoid; Bioastin® Technical Bulletin #062, Cyanotech Corporation, October 2000, pp.1-19
3) Lorenz, R.T.; Bioastin®, Nature’s Premier Astaxanthin Source; NatuRose™ Technical Bulletin #078; Cyanotech Corporation, October 2000, pp. 1-13
4) Naguib, Y.M.A.; Antioxidant Activities of Astaxanthin and Related Carotenoids, Journal of Agricultural Chemicals, 2000, 48, pp. 1150-1154
5) Kurashige, M. et. al.; Inhibition of oxidative injury of biological membranes by astaxanthin, Physiological Chemistry and Physics and Medical NMR, 1990, 22 (1), pp.27-38



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Anti-Aging Nutrients
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Date: June 18, 2005 09:07 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Anti-Aging Nutrients

Anti-Aging Nutrients by Edward C. Wallace, DC, ND Energy Times, February 3, 2000

What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful, easy feeling.

How Do We Age?

Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

Programmed Cell Theory

In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

Free Radical/Oxidative Stress Theory

The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain. On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents.

Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution. Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

DNA Repair Theory

Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

What Can We Do?

The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

Antioxidant Protection

Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.) Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725). Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

Nutrition Deficiencies

A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

Longevity Diets

A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460).

Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers (Epidemiology 3[5], 1992: 389-391).

Staying Alive

Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

Longevity and Exercise

Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184). In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

The Treadmill of Life

The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying (JAMA 273 [14], April 12, 1995: 1093-1098).

Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

Longevity Supplementation

Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging. Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

Toning Down Enzymes

Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls. In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

Vitamins E & C

A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

Chronological Age Vs.Biological Age

Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems.

In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

Similar Relationship

A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less.

And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

Carotenoids

When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119[1], Jan. 1989: 112-115).

Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

Flavonoids

Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs. For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

Amino Acid Health

Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68). As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

Attitude & Behavior

Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit. In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

Longevity at Last

While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of longer life. And by staying healthier, your old age will be more enjoyable, too.



--
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=377)


Nutrients for Longevity
TopPreviousNext

Date: June 10, 2005 09:59 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Nutrients for Longevity

Nutrients for Longevity by Edward C. Wallace, ND, DC Energy Times, September 1, 1999

What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful easy feeling.

How Do We Age

Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

Programmed Cell Theory

In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

Free Radical/Oxidative Stress Theory

The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain.

On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents. Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution.

Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

DNA Repair Theory

Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

What Can We Do

The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

Antioxidant Protection

Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.)

Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725).

Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

Nutrition Deficiencies

A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

Longevity Diets

A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460)

Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers. (Epidemiology 3[5], 1992: 389-391).

Staying Alive

Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects. (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

Longevity and Exercise:

Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184).

In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

The Treadmill of Life

The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying. (JAMA 273 [14], April 12, 1995: 1093-1098).

Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

Longevity Supplementation

Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging.

Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

Toning Down Enzymes

Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls.

In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

Vitamins E & C

A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

Chronological Age Vs. Biological Age

Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems. In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

Similar Relationship

A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less. And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

Carotenoids

When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119(1), Jan. 1989: 112-115).

Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

Flavonoids

Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs.

For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

Amino Acid Health

Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68).

As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

Attitude & Behavior

Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit.

In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

Longevity at Last

While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of living longer. An added benefit: By staying healthier, your old age won't only be longer, it will be more enjoyable, too.

And, who knows, if you hang around long enough, taking your nutrients and getting a comfortable amount of consistent exercise, while meditating and refusing to succumb to stress, that magic bullet that will keep you alive for centuries may be discovered. Some day a new antioxidant or other substance may finally prove to provide the elusive fountain of youth. Stay tuned.



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