|
Search Term: " Dismuase "
Curcumin: The Superfood That Fights Inflammation   
Date:
April 30, 2022 09:39 AM
What is inflammation and what causes it? Inflammation is a natural process that helps the body heal. It occurs when the immune system responds to an injury or infection. The symptoms of inflammation include redness, swelling, and pain. While inflammation is a necessary part of the healing process, chronic inflammation can lead to serious health problems. Chronic inflammation is often caused by lifestyle factors, such as smoking, obesity, and stress. dietary factors can also contribute to chronic inflammation, including a diet high in sugar. Sugar causes the body to release inflammatory chemicals that can damage tissues and lead to disease. Therefore, reducing sugar intake can help to reduce the risk of chronic inflammation. What are the symptoms of inflammation? Inflammation is a natural process in the body that helps to protect us from injury and illness. It occurs when the immune system detects harmful stimuli, such as pathogens or damaged tissue, and triggers a series of reactions which boost the production of white blood cells. However, if inflammation becomes excessive or chronic, it can cause a range of physical symptoms, including redness and swelling at the site of inflammation, increased pain sensitivity, headache, fatigue and fever. Other common symptoms include irritation in the eyes and mouth, digestive issues like diarrhea and nausea, rashes or skin lesions, changes in appetite and mood swings. If you are experiencing any of these symptoms on a regular basis, it is important to take anti-inflammatory supplements to help control inflammation. One such supplement is curcumin. How can curcumin help to reduce inflammation in the body? Curcumin is a compound that can be found in turmeric, a bright yellow spice commonly used in cooking. This powerful phytochemical has been shown to have potent anti-inflammatory properties, and can help to reduce inflammation throughout the body. One of the main ways that curcumin achieves this effect is by blocking an enzyme known as cyclooxygenase, or COX. This enzyme is responsible for producing pro-inflammatory compounds called prostaglandins that are often associated with pain and swelling. By preventing their production, curcumin can help to control acute and chronic inflammation in the body, thereby reducing the risk of conditions such as arthritis, heart disease, and cancer. In addition to blocking COX activity, curcumin helps to reduce oxidative stress by inducing production of antioxidants like superoxide dismutase. Overall, these mechanisms make curcumin an excellent natural treatment for chronic inflammation and a host of related health problems. How to add curcumin to your diet? Adding curcumin to your diet is a great way to reap the many health benefits of this powerful natural compound. There are several different ways that you can incorporate more curcumin into your daily routine, from simply adding it to your favorite recipes to taking a supplement. For example, you can start off by incorporating turmeric into your cooking, as turmeric is one of the richest sources of curcumin in nature. Additionally, there are many curcumin supplements available on the market that can be easily incorporated into your daily routine. Ultimately, by making these simple changes in your diet, you can enjoy all the great benefits of curcumin for overall health and well-being. The benefits of taking curcumin regularly Curcumin is a compound found in the spice turmeric. It has powerful anti-inflammatory and antioxidant effects, and it has been used for centuries in traditional Chinese and Indian medicine. Recently, curcumin has begun to gain recognition in the Western world as well. A growing body of research suggests that curcumin may have a wide range of health benefits, including the ability to improve cognitive function, reduce inflammation, and even ward off cancer. Curcumin is generally well tolerated, but it can interact with certain medications. However, for many people, taking curcumin regularly can be a safe and effective way to improve overall health. To fight inflammation, reduce sugar consumption and take curcumin To help reduce inflammation in the body, it is important to reduce your sugar intake and take curcumin supplements. These steps are vital because chronic inflammation has been linked to a wide range of health conditions, such as heart disease, diabetes, and even cancer. Additionally, sugar consumption can also worsen inflammation by triggering the release of inflammatory chemicals like cytokines and free radicals. One of the best ways to fight against inflammation is to take curcumin supplements on a regular basis. Curcumin is a natural anti-inflammatory agent found in turmeric, a spice that is commonly used in Indian cooking. Research has shown that curcumin can be just as effective as anti-inflammatory drugs in reducing levels of tumor necrosis factor alpha (TNF-alpha), a potent inflammatory chemical released by cells. Furthermore, studies have also shown that taking curcumin regularly may benefit overall health and prevent certain age-related diseases like Alzheimer's. Overall, reducing your sugar intake and taking curcumin supplements are two effective ways to fight inflammation and improve overall health. By following these simple steps, you can help protect yourself from the many negative effects of chronic inflammation.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6401) 10 Reasons You should Be Taking curamed daily! 
Date:
September 05, 2017 12:21 PM
Order Today! Call 1-800-877-8702
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5225) Tree nuts literally fight cancer in the human body
Date:
February 21, 2017 02:59 PM
People who eat nuts in their adolescence may have a better chance of fighting off breast cancer later in life, according to data from the Harvard Nurse’s Study. A follow-up study involving the daughters of the nurses corroborated the findings. Those eating more peanut butter, nuts, beans, lentils, soybeans, or corn were found to have just a fraction of the risk for fibrocystic breast disease, which places one at higher risk of cancer. The protective effects were found to be strongest for those most at risk, such as those with a family history of breast cancer. Key Takeaways:
"Eating nuts consistently (and consciously) is perfect for pumping up heart protection, warding off obesity, and keeping clear of diabetes." Reference: //www.mensfitness.com/nutrition/what-to-eat/tree-nuts-literally-fight-cancer-human-body
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3991) Superoxide Dismutase (SOD) and its Protection of the Liver
Date:
September 27, 2015 08:37 AM
SOD consists of enzymes that speed up the break-down or partition/dismutation of the superoxide (O2-) radical into its constituent molecular content Oxygen or hydrogen peroxide. Superoxide is harmful to cells and is produced as a by-product of oxygen metabolism; therefore it needs to be controlled or regulated. The resultant Hydrogen peroxide is also harmful but to a less extent, and it is further broken down by other enzymes like catalase, This sums up the crucial role played by Superoxide Dismutases (SOD) as an important antioxidant in almost all living organism exposed to oxygen. SOD extracted or laboratory manufactured can be used as a medicine orally or taken as an injection. When taken orally it is believed to remove wrinkles, rebuilding tissue, and prolonging life; even though it is not proven that orally administered SOD is absorbed by the body. When injected it functions as a painkiller, treatment of inflammation caused by sports injuries, osteoarthritis, kidney condition known as interstitial cystitis, gout, cancer, lung problems in infants among others. A critical role played by SOD IS the protection of the Liver; which is one of the most crucial organ in the body for it is engaged in high-level metabolism in its function of detoxifying chemicals, breakdown of drugs and conversion of certain food into necessary nutrients for the body. These processes entail the high use of oxygen needed by the liver cells in the effort to function optimally and thus the production of the harmful Superoxide as a by-product. SOD as an enzyme helps to break down this harmful by-product that is potentially harmful to the liver cells and consequently prevent tissue damage. SOD also prevents oxidative tissue damage of the liver as the result of strenuous exercise. Exhausting exercise or running causes a significant surge in the activities of glutathione peroxidase (GPX), and xanthine oxidase (XO), and in addition to increased levels of thiobarbituric acid-reactive substances (TBARS) in liver tissue immediately after the activity. Scientific studies have revealed that effective protection of the liver against such oxidative damages requires increased dosage of the antioxidant SOD.
Reference: //www.ncbi.nlm.nih.gov/pubmed/8820884
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3223) What Is Super Oxide Dismutase (SOD)?
Date:
December 29, 2012 12:06 PM
Super Oxide Dismutase is an important enzyme that plays an important role in protecting the cells from free radical damage. Enzymes are compounds that work by speeding up certain chemical processes in the body. Super oxide dismutase speed up the process of transforming superoxide into oxygen and hydrogen peroxide, making SOD an important component in the processes of providing oxygen to the cells. Without oxygen, cells eventually stop functioning and die. Benefits of Super Oxide Dismutase (S.O.D) This enzyme is present in various living organisms even in some bacteria species that do not utilize oxygen. Because of its function in providing oxygen to the cells, super oxide dismutase is important in keeping cells healthy and ensuring the function of all organs in the body. Without it, cells rapidly age and die, and the body becomes exposed to various kinds of diseases and infections. This becomes more pronounced in individuals who are constantly exposed to pollution and other sources of free radicals. Fortunately, the enzyme is available as a supplement for those who want to ensure that they have the right amounts of super oxide dismutase in their systems. It is important to seek professional consultation before taking the enzyme, but it is often allowed for most people in varying degrees of health. Top Uses of Super Oxide Dismutase Super oxide dismutase is often used to treat various types of organ malfunctions like bladder infections as well as to prevent lung infections in newborns suffering from compromised respiratory systems. This is very important in premature newborns since giving oxygen to a newborn can damage his lungs. The enzyme is also used by bodybuilders and those who want to stay fit and healthy since it enhances oxygen delivery and promotes longer endurance when working out. The antioxidant property of SOD also helps in keeping cells healthy and supports cell tissue repair after strenuous workouts.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2796) Chronic fatigue syndrom and your life styles
Date:
September 01, 2010 07:55 PM
Fight Chronic Fatigue SyndromChronic fatigue syndrome strikes more than two million people in the United States, with eighty-five percent of these people being women between the ages of thirty and fifty. The symptoms of chronic fatigue syndrome often resemble many other viral infections, making it very hard to pinpoint the real problem. This condition is possibly caused by stress as well as by mercury poisoning from amalgam fillings, hypoglycemia, anemia, hypothyroidism, sleep apnea, food and chemical allergies, weak adrenal function, parasitic infections, amino acid deficiencies, and Candida albicans infections. With all of this in mind, there are a couple of herbal combinations and healthful suggestions that can be followed to help prevent or deal with chronic fatigue syndrome.Cordyceps sinensis is a natural Chinese supplement that contains high amounts of L-tryptophan. It provides nutrients that are necessary for relieving fatigue and improving endurance. It also helps to increase blood supply to the heart and brain. This herb increases the production of superoxide dismutase in the body. In China, this herb has been traditionally used to treat the nervous system. Additionally, it is used to help strengthen the kidneys and liver. An herbal combination containing bee pollen, licorice, kelp, barley grass, schizandra, gotu kola, eleuthero, yellow dock, rose hips, and capsicum has been shown to help restore energy to the system. This combination is an excellent combination of herbs to feed and nourish the entire system. It provides nourishment for the adrenals, in the form of licorice, and also for the thyroid, in the form of kelp. The bee pollen in this combination helps to nourish and supply energy to the body. Barley grass nourishes and cleans the body, while schizandra, which is an adaptogen herb, increases the energy supply of cells in the brain, muscles, liver, kidneys, glands, nerves, and in the entire body. The combination of herbs will rebuild the blood, liver, and digestive system.
The following are a few suggestions that can be followed to help deal with and prevent chronic fatigue syndrome. Exercise is very helpful, with even mild exercise helping to increase stamina and oxygenate cells. Exercise also helps to improve sleep. Allergies can be involved in chronic fatigue syndrome, so it is important to look into food allergies, chemicals, and heavy metals, and eliminate them. Anytime there is inflammation in the body that is accompanied by pain, swelling, heat, and redness, allergies are likely the culprits. When the immune system is weak, candida is usually involved.
Candida and Chronic Fatigue SyndromA candida diet would help to restore natural flora to the system. Candida can prevent the body from using sugars properly, which blocks the body’s energy production and causes extreme fatigue. To restore the friendly bacteria, use acidophilus on an empty stomach and eat unsweetened yogurt. If candida is involved, it is important to eliminate sugar, alcohol, mushrooms and all fungi, molds, and yeast in any form. It is also important to eliminate fermented foods. Look into leaky gut syndrome, which typically allows germs, viruses, bacteria, worms, and parasites to flourish. When they flourish, the immune and nervous system become weak, causing diseases such as chronic fatigue syndrome to weaken the body. Trying natural remedies like Fatigue to fantastic herbal supplements may help ease chronic fatigue.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2181) Barley Grass
Date:
May 14, 2009 01:22 PM
Barley is a cereal grain that is derived from the annual grass known as Hordeum vulgare. This nutrient serves as a major animal feed crop, but also is used for malting and in health food. Barley is also used in the making of beer and whisky. In a 2005 ranking of cereal crops in the world, barley was ranked number four in both quantity produced and area of cultivation. It is still used as a major food in the middle east. Barley is a member of the grass family, descending from and inter-fertile with wild barley. For this reason, the two forms are often treated as one species. The main difference between the two forms is the brittle spike on the seeds of the wild barley, which help with dispersal. Barley tends to be more tolerant of soil salinity than wheat, which potentially explains the increase of barley cultivation in Mesopotamia from the 2nd millennium BC and forward. Although barley is not as cold tolerant as the winter wheat, fall rye, or winter triticale, it can be planted as a winter crop in warmer areas of the world like Australia. It is important to note that barley not only as a short growing season, but it is also relatively drought tolerant, making it an easier plant to grow. Barley was valued by the ancient Egyptians and Greeks for its immense health benefits. Because of this, it was cultivated. Hippocrates even wrote of the benefits of gruel that is made from barley. New World settlers planted barley in order to sustain both health and vitality. Barley juice contains antiviral properties that help to strengthen the immune system. This herb can help cleanse the body on a cellular level. It can also normalize metabolism and neutralize heavy metals in the body, such as mercury. Barley can benefit the body by lowering cholesterol levels, aiding digestion, and relieving constipation. This herb also strengthens the entire body as a whole. One study done in Japan separated a new antioxidant that has been found in barley leaves called 2-0-GI. This antioxidant was found to be effective in the preservation of food. 2-0-GI was also found to have anti-inflammatory and antiallergenic activity. Another Japanese study found beneficial results in barley’s ability to inhibit the AIDS virus. Both the juice and powder made from the young leaves and grass of barley are helpful in producing adaptogen, alterative, anti-inflammatory, antioxidant, antiviral, blood purifier, demulcent, emollient, immunostimulant, nutritive, and stomachic properties. The primary nutrients in this herb include calcium, chlorophyll, iron, live enzymes, magnesium, potassium, protein, superoxide dismutase (SOD), and vitamins B1, B2, and C with bioflavonoids. Primarily, barley is beneficial in helping to treat anemia, arthritis, and impurities in the blood, boils, cancer, and metal poisoning. However, this nutrient also offers great benefits with acne, AIDS/HIV, allergies, hay fever, bronchitis, candidiasis, eczema, herpes, infection, kidney problems, leprosy, liver disorders, lung disorders, psoriasis, skin conditions, syphilis, tuberculosis, and ulcers. For more information on the many benefits that barley has to offer, please contact a representative from your local health food store.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Barley is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2007) Protect Your Skin
Date:
August 11, 2008 03:20 PM
SOD, which is short for superoxide dismutase, is an antioxidant that is found in small, insubstantial quantities in the body. It reduces potentially harmful free radicals. Research is also available that looks into antioxidants role in supporting healthy skin against the sun. However, SOD’s benefits have only recently begun to be studied. One studied found that SOD supported skin health against the photo-oxidative stress that is caused by UV radiation better than any other antioxidant. Two studies have found that the oral consumption of carotenoids from tomatoes such as lycopene, phytoene, and phytofluene helps to maintain healthy skin by protecting it against the damage induced by UV rays. Topical application of currently available sun care products provides limited protection against UV light, as even so-called quality products allows some light to still penetrate the skin which causes damage and wrinkling. To provide optimal protection, supplementing the diet with natural antioxidants, especially lycopene, is essential along with applying sun care products that contain UV-B and UV-A filters. Many studies have been done to examine the photo-protective effects of lycopene. It has been shown that this nutrients decreases reddening of the skin. A second study, which involved three groups of antioxidants and two different groups of antioxidant supplements that contained carotenoids and selenium, tested the impact of these nutrients on skin structure and health. After 12 weeks, a significant increase in skin density and thickness, an improvement in skin smoothness and softness, and reduced scaling were the results of using these nutrients. There are many all-natural extracts that contain lycopene, and a complex of tocopherols, beta-carotene, phytoene, and phytofluene. These supplements increase the levels of antioxidants in the skin, which enhances the body’s natural defenses against UV-induced skin damage, supports healthy skin structure, and helps to prevent premature aging of the skin. Zinc oxide is said to provide the most abundant wavelength protection of any sunscreen ingredient, which uniformly covers from 290 to 300 nm, allowing it to protect against UV-B and most of the UV-A rays. Recent studies have shown that topical vitamins C and E offer greater photo-protection than what was previously realized, delivered protection four times stronger, offered seventy percent sunburn reduction, and prevented the formation of thymine dimmers, which are signature DNA mutations found in non-melanoma skin cancers. Actually, a study that was published in the Journal of the American Academy of Dermatology determined that a combination of topical vitamins C and E were better for UV protection to skin than an equivalent concentration of topical vitamin C or E alone. Additionally, the combination of vitamins C and E provided protection against thymine dimmer formation. In order to obtain appreciable photo-protection, a combination of topical vitamins C and E is necessary. Medical experts also suggest that all of the above natural products may protect against skin cancer, photo-aging and the effects that go along with them. For more information on these nutrients and the helpful capabilities that they are able to provide for your body, be sure to contact your local health food store. Sun Care Moisturizers And Creams
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1861) Copper
Date:
May 15, 2008 01:21 PM
Copper is an essential trace mineral necessary for life, and it is necessary for the proper function of certain enzymes that allow certain biochemical functions of the body to take place. Without copper neither plant nor animal life would be possible. Dietary sources include nuts, grains, seeds, beans and other vegetable protein sources. Although it is also obtained from animal sources, these tend to be rich in zinc, and for reasons that will be discussed shortly, the presence of zinc can deplete copper absorption. Other common sources are copper cooking utensils and drinking water from copper pipes. After digestion, copper is absorbed into the body through the stomach and the small intestine. It is also possible for copper to be absorbed through the skin from copper bracelets. Once absorbed, copper is bound to albumin and taken by the blood to the liver, where it is bound to a plasma protein known as ceruloplasmin. Among the enzymes with which copper is associated as a ‘helper’ are Cytochrome C oxidase, used in the conversion of glucose to energy, Dopamine hydroxylase, an essential component in the biochemical production of adrenaline, and superoxidase dismutase, that protects against the oxidative damage of cell tissue. Of particular benefit are its anti-inflammatory and antioxidant properties, and its role in energy production. Because of its antioxidant effect, copper could well play a very important role in protecting against atherosclerosis, and cardiovascular disease, the ravaging effects of free radicals on body cells and also certain forms of cancer. Copper is also important in electron transport, and is responsible for the blue coloration of the blood of most molluscs and many arthropods. This is because rather than hemoglobin, these animals use the copper-based hemocyanin for oxygen transport in the blood. Rather than the iron-containing hemoglobin making the blood of these creatures red as it is with mammals, theirs is blue due to the hemocyanin. Copper salts are generally green and blue, as are the blue copper proteins plastocyanin and azurin. So how is copper used by the body? It is, after all, fairly toxic, as little as 30 grams being fatal to humans, bringing on similar symptoms to those of arsenic poisoning. It is in fact the reason for its toxicity that also renders it so useful to the body. The toxicity is largely due to the ability of copper to accept and donate electrons as it changes between oxidation states. This results in the generation of very reactive radicals that can cause severe oxidative stress. The complete reason for its toxicity has yet to be determined, but the stress caused to body cells by free radical oxidation is a very serious condition. It is this rapid change in its oxidation state that is valuable to the enzymes with which it is associated. The ceruloplasmin is responsible for most of the transport of bivalent copper around the body, in the tissues of which it helps to form the bivalent copper enzymes previously mentioned, such as Cytochrome C oxidase and Lysyl oxidase. In doing so the copper is converted to the monovalent state. It also helps to aid in the production of the strong antioxidant Superoxide dismutase (SOD). What this enzyme does is to catalyze the formation of oxygen and hydrogen peroxide by the dismutation of superoxide, a negative ion consisting of two oxygen atoms and a free electron, and hence a very powerful free radical. Dismutation is the simultaneous oxidation and reduction of the species, rendering the free radical relatively harmless. This type of action on free radicals is a very powerful one, and essential in the body’s fight against such free radical species that are so dangerous to animal cells. SOD exists in more than one form, and can also contain zinc, manganese and nickel in addition to copper. The internal fluid (cytosol) of practically all eukaryotic cells (cells containing a nucleus) contain a form of Superoxide dismutase dependent on copper and zinc, while most mitochondria contain an SOD with manganese. Another of the important uses that your body can find for copper lies in the production of hemoglobin. This is because copper is needed for the storage and release of iron to produce hemoglobin, the protein in red blood cells. It is believed that ceruloplasmin is involved in the catalytic formation of ferric iron by the oxidation of ferrous iron, so allowing the iron to be attached to a protein that transfers it round the body to enable its use in the biosynthesis of various ferrous compounds, especially of hemoglobin. Copper bracelets are commonly worn by arthritis sufferers, and there is a scientific explanation for that. As previously inferred, it is believed to be possible to absorb copper through the skin and copper is known to be involved in the formation of collagen and is a commonly used treatment for arthritis and osteoporosis. Part of its effect on arthritis is likely due to the antioxidant effect of the SOD that helps to reduce the inflammation at arthritis sites. Although a deficiency in copper can lead to serious health problems, an excess is also harmful. Potential conditions include neurological problems, liver damage and bone abnormalities, although deficiency is far more common because of the competition between copper and zinc. Zinc is a copper antagonist, as is iron and manganese, and copper imbalances can be moderated by the use of these as supplements. The symptoms of a copper deficiency include fatigue, hair loss, stunted growth, anorexia and a host of other conditions. Luckily, however, a deficiency is rare and most people receive a sufficient amount of copper in their diet. Supplements are available to ensure an adequate intake. There is still much to be learned about the interaction between copper and enzymes, and there is also a great deal still to be learned of its role in human metabolism and biochemistry than is currently known. However, sufficient is known already for us to be certain that copper is a very important trace element and that we should be certain that our intake is sufficient, given that zinc iron and manganese compete to prevent copper being absorbed by the body.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1790) Did you know GliSODin can do this?
Date:
June 08, 2006 12:01 PM
GliSODin – The Antioxidant Catalyst GliSODin promotes the most powerful antioxidant known, those in the body’s own internal antioxidant defense system. Although dietary antioxidants are certainly important, they only play a supporting role. GliSODin takes an entirely different approach – it stimulates the body’s production of its own antioxidants – including superoxide dismutase (SOD) Glutathione Peroxidase (Gpx), and catalase. These provide the first and most important level of defense against oxidative stress. So add GliSODin to your diet and help your body protect itself. Get the complete solution to antioxidant protection and enjoy real health benefits! *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1307) GliSODin Anti-Aging and Antioxidant Protection
Date:
December 19, 2005 08:47 AM
GliSODin Anti-Aging and Antioxidant Protection
In the time it takes you to finish reading this article, you, your body and your cells will have aged. Some, more than others. Nevertheless, every second that ticks away should serve as a reminder that our time here is temporary. How much time we actually end up with depends on many things. Diet. Lifestyle. Environment. Superoxide Dismutase? I’ll explain. What some of the healthiest individuals fail to realize is that our bodies age from the inside out. Aging is not the result of passing time, but rather the result of what we’re exposed to environmentally, physically and chemically. It is the integrity of our cells, not our clocks, that determine how smooth the aging process fares. Each day, we’re subjected to millions of elements that affect us in ways seldom seen, felt or noticed. From the moment we’re born, we rely on our cells to work around the clock - producing energy, fighting infections and sustaining life. These same cells eventually determine the rate at which we show (or hide) our age. Taking into consideration that our planet has no shortage of toxins & germs, the need to safeguard our cells becomes very real. Constant exposure to exhaust, secondhand smoke, heavy metals, lead, fluoride and uncountable other noxious compounds should ideally provide us with nothing more than a routine immune system workout. Unfortunately, over long periods they hinder our “resistance” abilities and become stepping stones to accelerated aging. Antioxidants. We’ve all heard the term before, and may even have a general understanding of their role. But to better grasp just how vital they are, it helps to know what’s happening at the cellular level. Free radicals are unstable molecular thieves that often lack electrons. To compensate, they rob healthy cells - a process better known as oxidation. Antioxidants work with the immune system to prevent oxidation, and clean up the mess it leaves behind. Hence, the name. There are two types. Exogenous antioxidants are derived from our diet and include vitamins A, E, and C along with others such as alpha lipoic acid, selenium, CoQ10, grape seed, pycnogenol and zinc. To date, we’ve been limited to exogenous antioxidants as a way to increase the rate at which our body wards off oxidation. They are not, however, our first line of defense. At birth, each and every one of us is equipped with three primary endogenous enzymatic antioxidants; SOD (Superoxide Dismutase), Glutathione Peroxidase (GPx) and Catalase. While both types of antioxidants are beneficial, we’ve become reliant on those from the diet to compensate for our inability to boost the effectiveness of our 3 primary antioxidants. For years, researchers have been examining ways to enhance the activity of our built-in bodyguards. One in particular, Superoxide Dismutase (SOD) has been of foremost interest. SOD targets what many researchers regard as one of our greatest health threats and aging accelerators - Superoxide radicals. These highly reactive, merciless molecules incite enormous amounts of oxidative stress and are capable of wreaking havoc on healthy cells. When cells are left unprotected by SOD, the results can be disastrous - respiratory problems, premature aging, memory loss, cardiovascular challenges, vision failure and joint structure damage, among others. Until now, we’ve been at the mercy of our natural SOD reserves to fight superoxides. Researchers have been working feverishly to produce an effective oral SOD supplement, but have continually encountered a frustrating hurdle - exposure to gastric acid denatures SOD, rendering it useless. As a result, the only effective way to supplement SOD was through injections. These, however, only yielded short-term spikes. And then something remarkable happened that changed everything. Nutrition scientists in France determined that by combining Cucumus melo (a melon high in SOD) with a wheat gliadin stabilizer, it would be possible to prevent SOD from deteriorating in the digestive tract, while preserving it in the blood for extended periods. Not only is this the answer to a puzzle that has plagued researchers, it’s a breakthrough that will impact the life of anyone seeking longevity and vitality. As the first proven oral SOD supplement ever introduced to the public, GliSODin® has taken antioxidant protection, immune support and antiaging science to an entirely new level. The primary function of GliSODin® is to scour the body for superoxide radicals and reduce them to less reactive ions that can be swept away; a process known as dismutation. In addition, GliSODin® reduces the oxidation vulnerability of healthy cells, protects mitochondrial activity and safeguards DNA structure. What’s most remarkable is that GliSODin® has actually been shown to stimulate the body’s own natural production of all three enzymatic antioxidants, including SOD. For the first time in history, we will have the ability to enhance the effectiveness of our body’s primary defense mechanism. New GliSODin® from NOW® represents the ultimate in antioxidant protection. By increasing one’s level of SOD while stimulating the natural production of Glutathione Peroxidase and Catalase, GliSODin® delivers antioxidant protection unlike any previously released dietary supplement. Remember, the aging process begins at a level that we simply can not see, the cellular level. Shielding your cells from superoxide damage is one of the smartest steps you can take against aging before your due time. GliSODin® has made this a reality.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1037) The Free Radical Theory
Date:
December 14, 2005 12:11 PM
The popular theory has been the subject of a great deal of research. Developed by Denham Harman, M.D., Ph.D., at the University of Nebraska in 1956, the free radical theory proposes that unstable molecules known as free radicals are responsible for inflicting extensive cellular damage, which causes cell death and dysfunction and eventually, disease. The most common type of free radicals are oxygen derived, and free radical damage is often referred to as oxidation. Environmental sources of free radicals include radiation (I.E., sun exposure, X-rays), ozone and nitrous oxide, heavy metals (i.e., mercury, cadmium, lead), smoke, alcohol, saturated fat, and other chemicals and pollutants. The body itself generates free radicals in performing essential bodily functions including energy production and immune activities. Fortunately, the body also has the ability to create antioxidants to neutralize the free radicals and prevent extensive cellular damage. When free radicals are not neutralized by antioxidants, they inflict large-scale cellular damage which can cascade and lead to age-related degenerative diseases such as osteoarthritis, osteoporosis and age –relaged macular degeneration. For example, free radical damage to joint cells may cause the cartilage to become rough or break down, and can lead to the development of osteoarthritis. Antioxidants are needed to comb at free radicals and prevent this cellular damage. “Oxidative stress can lead to DNA mutations, cell death, and disease, all of which contribute to aging,” said Gerald R. Cysewski, president and chief executive officer (CEO) at Cyanotech corp. “Antioxidants are produced naturally by the body to combat oxidative stress by neutralizing free radicals. Increasing the amount of antioxidants in one’s system by consumption of supplements can provide further protection from the damaging effects of free radicals.” Because the body is continually assaulted by free radicals, antioxidant supplementation is often necessary. “by taking certain nutrients that our bodies stop producing over time, supplements help us to maintain a youthful look and health, which in turn enhances the quality of life,” Alkayali said. “Furthermore, supplements can help decrease oxidative stress that may otherwise accompany age-related illness and disease.” Many Substances are known antioxidants including certain enzymes, vitamins, phytochemicals and minerals, and include Vitamin C, Vitamin E, alpha-lipoic acid, coenzyme Q10 (CoQ10), Carotenoids, Selenium, superoxide dismutase, melatonin, quercetin, catechins, and zinc. Consuming a diet high in plant sources of powerful antioxidants is an important step to deter ageing, because nutrients from foods are often highly bioavailable and can act synergistically to increase their health benefits. Garlic contains several antioxidant phytochemicals and minerals including allicin, beta-carotene, quercetin, selenium and zinc, and may have a protective effect against stomach and colorectal cancers. Catechins are potent antioxidants flavonoids, with the best known source being green tea; they include gallocatechin (GC), epigallocatechin (EGC), epicatechin (EC) and epigallocatechin gallate (EGCG). These antioxidants are being studied for their powerful abilities to combat free radical damage. In particular, EGCG has been researched for its reported protection against certain cancers and Alzheimer’s disease. Green Foods such as seaweed, sea vegetables, young grain grasses and shoots, broccoli, cabbage and other green leafy vegetables pack a nutritional punch due to their concentratged amounts of antioxidant carotenoids, vitamins and the enzyme superoxide dismutase (SOD). SOD is produced by the body and neutralizes free radicals known as superoxide radicals, which cause damaging fat oxidation. GliSODin is a patented form of SOD derived from cantaloupe and bound to a wheat protein for superior bioavailability. “GliSODin promotes the body’s production of its own endogenous antioxidants, including SOD, catalase and glutathione peroxidase, in virtually every cell,” said Eric Anderson, brand manager at P.L. Thomas. “This activation of the cellular antioxidant defenses across the whole body creates a state of alertness against any shock of oxidative stress, including sun rays, to which our body may be exposed.” Pomegranates contain two powerful antioxidants—ellagic acid, derived from fruit’s seeds, and punicaligans, found in the juice. “Research has shown that the juice from the pomegranate, rich in polyphenols, reduces oxidative stress by helping to produce enzymes to fight free radicals,” Alkayali said. NeoCell Corp. manufactures of ellagic-acid based Pomegranate Power, while P.L. Thomas supplies POM40p, a kosher-free pomegranate juice extract standardized to 40-precent punicocides, polyphenols belong to the punicalagin family. Consumer demand is on the rise for products that address degenerative health conditions, including supplements that support function of the bones, joints, eyes. According to a June 2005 report by the freedonia group, “Bone and joint care products will continue to dominate the health maintenance segment, spurred by a growing customer base and a plethora of new and improved products expected to soon enter the marketplace.” The report also projected rapid gains for vision care. “Demand for vision care products will be propelled by aging baby boomers who are becoming aware of debilitating eye conditions and seeking both preventive measures and ameliorative treatments.” Dietary Supplements can help prevent and ease symptoms of age-related diseases affecting the joints, bones and eyes, including osteoarthritis, osteoporosis and age-related macular degeneration (AMD).
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1013) Vitaberry Plus + Super Fruit Antioxidant
Date:
December 07, 2005 05:43 PM
Vitaberry Plus +™ Super Fruit AntioxidantBy Nilesh Patel, NOW Quality Assurance, April 20, 2005 Why are FRUITS AND VEGETABLES important? “Diets rich in FRUITS AND VEGETABLES may reduce the risk of some types of cancer and other chronic diseases.”- National Cancer Institute. OXYGEN AND ANTIOXIDANTS As we all know, “Oxygen is critical to life,” but is itself a double-edged sword. While oxygen is necessary to sustain life and for natural defense against microbes, too much oxygen in our cells can lead to the production of “free radicals” (mitochondrial respiratory chain) or ROS (Reactive Oxygen Species). Free radicals come in many forms - singlet oxygen, hydrogen peroxide, superoxideperoxynitrite, to name a few - but all have one commonality. Each has an unpaired (unbalanced) electron, a situation it remedies by stealing an electron from a stable molecule. This sets off a domino effect of oxidation, a chain reaction that usually ends up damaging cellular integrity and compromising overall health. Nature has a defense system in place to protect these processes in the form of antioxidants. Whether endogenous (produced by the body, such as liver enzymes, SOD, coenzymes and sulfur-containing compounds) or exogenous (obtained through the diet, such as vitamins C & E, bioflavonoids, carotenes, etc.), antioxidants “quench” free radicals by donating an electron to stabilize a molecule, thus controling the chain reaction and stopping the oxidation “domino effect”. ANTIOXIDANT-RICH FOODS Research suggests that eating plenty of foods high in antioxidants helps to slow the processes associated with aging and protect against many chronic diseases. Maximizing one’s antioxidant power will enhance overall health. Fruit and vegetables contain both nutritive and non-nutritive factors that can affect oxidative damage and enzymatic defense and might contribute to redox (antioxidant and prooxidant) actions. A new “6-a-day” study looked into the effects of fruits and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers by The Danish Institute for Food and Veterinary Research in Denmark. The study found that fruits and vegetables increase erythrocyte glutathione peroxidase activity and resistance of plasma lipoproteins to oxidation more efficiently than do the nutritive factors (vitamins and minerals) that the fruits and vegetables are also known to contain. Certain berries, such as blackberries, also contain salicylates, which are also linked to heart health and prevention of atherosclerosis. The protective effects of fruits and vegetables intake on both heart disease death and deaths in general have previously been demonstrated but researchers at the Human Nutrition Research Center on Aging at Tufts University, Boston. Quercetin is an anti-oxidizing flavonoid found in many berries (such as cranberries, bilberries, blueberries, strawberries, etc.) and can prevent CVDs (coronary vascular diseases), according to a recent Finnish study. All these natural plant polyphenols are responsible for the colors of many red and purple berries, fruits, vegetables and flowers. GOVERNMENT GUIDELINES The new federal guidelines released earlier this year by the U.S. Department of Health and Human Services (HHS) and U.S. Department of Agriculture (USDA) recommend eating more fruits and vegetables, combined, than any other food group -- five cups or about 10 servings a day for most adults. The amount of fruits and vegetables recommended has increased for men and women of every age. “Fruits and vegetables are the "good news" story of the new Dietary Guidelines for Americans for food-loving consumers, the industry and America's public health”, stated the Produce for Better Health Foundation (PBH). Eating a variety of colorful phytochemical-rich fruits and vegetables has been associated with lower risk of some chronic diseases such as cancer and heart disease. Many authoritative organizations such as the National Cancer Institute and The American Heart Association recommend getting phytochemicals from whole foods, such as fruits and vegetables, rather than from individual component supplements. The Scottish government is promoting healthy eating through a scheme designed to increase purchasing of fruit and nutritional foods. Scottish health minister Andy Kerr said, "This initiative shows that healthy eating can be good for customers and good for business." Scottish women are said to have the highest rates of death from lung cancer in the world as well as the highest rates in Europe for coronary heart disease. They also have low consumption of fruits and vegetables, shown in studies to help protect against some cancers and benefit heart health. ROS (Reactive Oxygen Species) Free radicals and oxygen free radicals play an important role in the development and progression of many brain disorders such as brain injury, neurodegenerative disease, and Down syndrome. Oxidative stress is an important factor in the etiology and pathogenesis of diabetes & is also linked to other host of degenerative health conditions. Fortunately, antioxidants are available to support the body’s defense and fight disease and aging. Examples of “Fast acting antioxidants” in the body (serum) are: uric acid (polyphenols), ascorbate, bilirubin, vitamin E (the later two are lipid soluble). Examples of “Slow acting antioxidants” are glucose, urea nitrogen etc. In short, free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated as by-products of normal cellular metabolism. Their deleterious effects are minimized in vivo (in the body) by the presence of antioxidant systems. How do Antioxidants work? Antioxidants are substances in plants that help maintain health. Antioxidants protect against damage to cells caused by too many “free oxygen radicals,” which form because of the effects of oxidation. Smoking, sunlight, heavy exercise, and pollution all increase oxidation in the body. Most people would benefit by eating more (five to nine or more servings) fruits and vegetables & colorful plant foods, such as purple, dark green, yellow, orange, blue, and red ones, each day. These have healthful pigments along with antioxidant nutrients such as vitamin C, carotenoids, beta-carotene, lycopene, lutein, zeaxanthin, vitamin E, selenium, flavonoids, and other beneficial substances. There are numerous ways in which these antioxidants affect, but can be explained in two groups: Alpha (a) Effects: This refers to the scavenging or neutralizing of free radicals. These effects do not change the way humans (or animals) feel. There are also no noticeable health, psychological or emotional benefits. While there are no obvious changes, increased total antioxidant intakes are associated with decreased tumor rates, prevention of heart attacks and increased longevity. Beta (ß) Effects: These are the changes on health, psychological or emotional state that you or others will notice. In this case, the antioxidant is affecting metabolic processes (enzymes) with consequent changes in the physical (improvement in joint movements, improved skin condition, tissue damage recovery), emotional (better ability to cope with stress) or psychological state (increased alertness). The ORAC value Because most of the active nutritional components in fruits and vegetables are antioxidants, accurate measurement of antioxidant activity serves as a good indicator of potential health benefit. Scientific opinion runs high that ORAC (Oxygen Radical Absorption Capacity) will eventually become a government standard of reference for overall daily fruits and vegetables intake. ORAC units are a measurement of the ability of food to stop oxidation. It is most generally expressed in terms of Trolox equivalent per gram (µmole Trolox equivalents (TE)/g). POPULATION DATA A survey done by the National Research Council indicates that only 10% of the US population consumes the recommended five servings of fruits and vegetables per day. The equivalent to eating 5 mixed servings of fruits and vegetables per day is about 1,670 ORAC units. Based on scientific evidence it is suggested that daily antioxidant intake should be increased to between 3,000 and 5,000 ORAC units per day, per human subject, in order to reach a significant antioxidant capacity in blood plasma and other tissues. WHAT IS NOW DOING TO HELP? In accord with our mission, “To provide value in products and services that empower people to lead healthier lives,” NOW® Foods is introducing an ALL-FRUIT-DERIVED antioxidant product called VitaBerry Plus +™ Super Fruit Antioxidant Vcaps (vegetarian capsules) (product number #3336). At time of manufacture this product provides an ORAC value of at least 2,500 units per serving from a full-spectrum antioxidant blend of fruits containing phytochemicals and phenolic compounds such as anthocyanins, proanthocyanins, chlorogenic acid, ellagic acid, quinic acid, resveratrol , many organic acids, resveratrol and vitamin C. VitaBerry Plus +™ is formulated with VitaBerry™ Hi-ORAC Fruit Blend [a proprietary blend of fruit extracts & concentrated powders containing Wild Blueberry (Vaccinium angustifolium) extract, Grape (Vitis vinifera) & Grape seed extract, Raspberry (Rubus idaeus) & Raspberry seed extract, Cranberry (Vaccinium macrocarpon), Prune (Prunus domestica), Tart Cherry (Prunus cerasus), Wild Bilberry (Vaccinium myrtillus) extract & Strawberry (Fragaria virginia)], Hi-Active™ Orange (Citrus sinensis) and Pomegranate (Punica granatum) min. 40% ellagic acid fruit extract. One gram of VitaBerry™ Hi-ORAC Fruit Blend provides at least 6,000 ORAC units (i.e., µmole Trolox equivalents (TE)/g). (Also watch for an upcoming antioxidant product from NOW called Enzogenol® (Pinus radiata bark extract from New Zealand) with Rutin (a flavonoid from South American fruit of Dimorphandra mollis) and Grapeseed extract. IS IT EFFECTIVE? Total ORAC value includes both lipophilic and hydrophilic components. VitaBerry Plus +™ contains only water/hydroethanol based extracts and concentrated (100:1 to 125:1) freeze-dried fresh fruit blends, so the lipophilic ORAC value is mere 2-4% of the total ORAC value. Glutathione peroxidase is a selenium-containing enzyme that decreases cell death from brain injuries. It also acts as a critical first-line antioxidant defense on the airway (respiratory) epithelial surface against ROS and RNS (reactive nitrogen species. Genetics research has found that the glutathione S-transferase gene controls the onset of Alzheimer’s, Parkinson’s disease etc. Taking glutathione (GSH) itself as a supplement does not boost cellular glutathione levels, since it breaks down in the digestive tract before it reaches the cells. So glutathione precursor dietary supplements (such as NAC and GliSODin), along with fruits and vegetables, are effective in boosting intracellular levels of GSH. The lungs have a defense system against the ROS oxidants consisting of low molecular weight antioxidants such as GSH and intracellular enzymes such as SOD, catalase and glutathione peroxidase to protect against the toxic effects of oxidants generated within the cells. Some of the primary effects of VitaBerry Plus +™ against the common reactive free-radical species or ROS are as follows: - Superoxide dismutase-SOD (destroys Superoxide radicals),- Catalase (neutralizes peroxides), - Functions similar to reduced Glutathione (GSH), - Glutathione peroxidase enzyme (detoxifies peroxides, using GSH as a reducing agent), - Functions similar to Glutathione S-transferase (GST), - Nullifies Superoxide-generating NADH/NADPH oxidase system In conclusion More concentrated than fresh berries, with over 6000 ORAC units per gram, VitaBerry Plus +™ provides consumers with the antioxidant power of almost 15 servings per day of FRUITS AND VEGETABLES ina convenient vegetarian capsule form! VitaBerry™ PLUS +™ (# 3336) provides a powerful, convenient way to supplement diets that do not include sufficient fruit and vegetable antioxidants Selected References: USDA/HHS guidelines report at: etaryguidelines/dga2005/document/
ls.com/proprietary/pdf/VitaberryBrochure.pdf g Kaplan M., Hayek T. , Raz A., Coleman R. and Aviram M. Pomegranate juice supplementation to apolipoprotein E deficient mice with extensive atherosclerosis reduces macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 131: 2082-2089 (2001) Lars O Dragsted et. al., The 6-a-day study:effects if fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. American Journal of Clinical Nutrition, Vol. 79, No. 6, 1060-1072, June 2004 Fuhrman B. and Aviram M. Polyphenols and flavaonoids protects LDL against atherogenic modifications.In: Handbook of Antioxidants Biochemical, Nutritional and Clinical Aspects, 2nd Edition. Cadenas E & Packer L (Eds.) Marcel Dekker, NY(Pub.). 16:303-336 (2001) Wood, Jacqueline, et al. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry 77 (2002) 155-161 Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. Free Radical Research 36 (Supplement 1): 71-72 (2002) Jennifer Schraag, Antioxidants: Nature’s Way of Balancing Life. HSR Health Supplement Retailer, Vol. 11, No. 2, 24-27, February 2005 com/news/printNewsBis.asp?id=58665 com/news/printNewsBis.asp?id=58697
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=992) GliSODin® (The Antioxidant Catalyst) 100 mg Fact Sheet
Date:
December 07, 2005 12:47 PM
GliSODin® (The Antioxidant Catalyst) 100 mg Fact Sheet Neil E. Levin, CCN, DANLA 01/31/05 LIKELY USERS: People with exposure oxidizing chemicals; People wanting to increase their body’s production of antioxidants. KEY INGREDIENT (S): SOD (Superoxide Dismutase antioxidant enzyme) from melons Organic Wheat Grass leaf MAIN PRODUCT FEATURES: Patented, clinically tested form of SOD to ensure absorbability; Protects cell mitochondria from oxidative stress that leads to genetic damage the cells; Reduces markers of cellular oxidative damage in the blood; May increase the body’s production of important antioxidants including SOD, Glutathione and Catalase. OTHER IMPORTANT ISSUES: This product contains wheat protein as an aid to protecting the SOD and increasing its absorption. The base of organic wheat grass synergistically provides additional, naturally occurring levels of SOD and other nutrients, though this additional SOD is not well absorbed. AMOUNT and HOW TO USE: One to three capsules a day, preferably between meals. If taken at mealtime avoid taking non-chelated (alkaline) forms of minerals at the same meal and take this capsule at the beginning of the meal to speed its transit time through the stomach and minimize exposure to alkaline foods and supplements that may cause the capsule to break down prematurely. That could potentially reduce the effectiveness of this form of SOD. The coating is designed to survive stomach acid and dissolve in the more alkaline conditions of the small intestine. COMPLEMENTARY PRODUCTS: Alpha Lipoic Acid, EGCg Green Tea Extract, Whey Protein Isolate, Selenium, NAC, Vitamin C, other Antioxidants. CAUTIONS: Contains wheat and wheat proteins, should not be used by people who are gluten-intolerant. Gluten intolerance may manifest with neurological, not abdominal symptoms, so please consider having a gluten intolerance test if you do have any neurological problems. Please notify your physician about your supplement use if you are using any drugs! Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCE: Free Radic Res. 2004 Sep;38(9):927-32. Influence of an orally effective SOD on hyperbaric oxygen-related cell damage. Muth CM, Glenz Y, Klaus M, Radermacher P, Speit G, Leverve X. Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum Ulm, D-89073 Ulm, Germany. PMID: 15621710 [PubMed - in process]
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=981) References
Date:
July 12, 2005 10:28 AM
References
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=597) The Immune System - with Kyolic Garlic
Date:
July 11, 2005 05:23 PM
The immune system is our body's natural defense system that keeps us healthy. Without it, invading organisms, which we come into contact with constantly, would cause illness and disease. There are many components of the immune system, including natural killer cells, T&B cells, macrophages and many others. Collectively, this network mainly functions against bacteria, viruses, fungi, and parasites. It is possible for the immune system to be suppressed. Things like stress, unhealthy habits, lack of nutrition, genetics, and other factors damage the immune system, which leaves us vulnerable to disease. The immune system can benefit from proper, and constant care. A healthy immune system can mean the difference between getting mildly sick versus something much worse. If you are looking for ways to boost your immune system via nutritional supplements, here are a few that might interest you: Aged Garlic ExtractTM (AGE): Numerous scientific studies have been conducted on AGE in relation to its effect on the immune system. Studies suggest that Aged Garlic Extract may support various immune factors,1-5 such as the ability of immune cells to engulf foreign organisms, T-lymphocyte activity,3 natural killer cell activity1,2 and antibody generation.6 Anti-fungal (Candida albicans-yeast) properties have been shown, and antiviral (herpes1,7, influenza8,9) properties have also been noted. Aged Garlic Extract has also been shown to modify, directly or indirectly, the function of immune cells, which play a leading role in allergic reactions including inflammation.10 In addition, Aged Garlic Extract has been shown to improve age-related deterioration of the immune response. For your convenience AGE is available as a liquid, and in a capsule, such as the Reserve, FORMULA 100 (tablet or capsule), or as the One Per Day (caplet). AGE also comes in combination with other herbs and nutrients that may further enhance the immune system. We have formulated a couple of products containing Aged Garlic Extract, specifically for the immune system due to the additional ingredients added that work as an extra boost in this area. Firstly, FORMULA 103 (brown/orange label) in addition to Aged Garlic Extract contains Astragalus, a potent herb demonstrating immune stimulating properties12-17 and vitamin C as Ester-C® (a unique form of Vitamin C) which may support healthy immune function.18 Another product, FORMULA 105 (pink/purple label), contains Vitamins A, C, E, selenium and green tea extract, which are very potent antioxidants. Antioxidants attack free radicals that cause damage to our body, leading to illness and aging. Please keep in mind that the various antioxidant functions attributed to AGE may also help to boost the immune system. Kyo-Green® is another one of our superb products. Mixing Kyo-Green in a juice or beverage may help to provide extra nutritional support since it is a source of vitamins, minerals, chlorophyll, superoxide dismutase (a very potent anti-oxidant enzyme) and other nutrients. A test tube study by Dr. Lau from Loma Linda University showed that Kyo-Green may provide nutritional support for the immune system by enhancing the activity of macrophages (immune cells that engulf foreign agents).19 Two teaspoons of Kyo-Green also provide the nutrients in a serving of vegetables so this product may function as an easy way to provide extra nutrition for the whole body. For those who may be interested in a more potent immune boosting formula, please try our Kyo-Green Harvest Blend The Harvest BlendTM contains all of the ingredients in the Kyo-Green, except for the kelp. However, in addition to these ingredients, other active ingredients are added to make forty-four ingredients in total, which may give the immune system a powerful kick. To help support your health there are many different greens, an immune-boosting herbal blend, antioxidant fruits and veggies, immune-enhancing mushrooms, an enzyme active sprout blend, a super energizing blend, special phytonutrients important to immune health, and a nutritious fiber blend. Please read the specifics on each of these constituents, available from the technical information available on this website. Finally, Kyo-Dophilus® is a probiotic supplement made of a combination of Lactobacillus acidophilus, Bifidobacteria bifidum, and Bifidobacteria longum, which help to maintain a healthy balance of the intestinal microflora and increase our first line of devense in the guy by enhancing macrophages and other immune factors by releasing immune boosting materials. This potent supplement of beneficial bacteria is also ideal for those taking antibiotics, those who are traveling or for those who just want to insure a plethora of beneficial bacteria in their intestinal tracts. Antibiotics are not selective in the bacteria that they kill off. When our friendly bacteria are wiped out, the bad guys have a window of opportunity to take over, as they grow much quicker than our friendly bacteria, and cause us problems. The lactic acid (friendly) bacteria have been shown to produce vitamins, enzymes and antimicrobial compounds that may improve the environment in the intestinal tract. Studies also suggest that friendly bacteria may help to increase resistance to some microbial infections.20-21 Kyo-Dophilus has demonstrated incredible stability at room temperature maintaining more than one billion live cells per capsule through its three-year shelf life. A minimum of one billion live cells per day is considered to be necessary to obtain desired effectiveness from a probiotic supplement. Kyo-Dophilus also comes in tablet form, in a nine-strain formation known as Kyo-Dophilus® 9, and in a smaller form for children, Kid's Kyo-Dophilus®. Supplying your immune system with adequate nutrition may promote health and ward of illness. If you give the body the tools it needs to heal it-self, it is amazing what it is capable of.
References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=569) NEW PRODUCT ANNOUNCEMENT
Date:
July 05, 2005 06:29 PM
The Most Comprehensive Antioxidant Formula Available!
Four tablets contain: Vitamin A (as beta-carotene 8,500 IU & palmitate 4,000 IU) 12,500 IU
gamma-Vitamin E Complex 500 mg
Quercetin 100 mg
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=548) GLISODIN POWER - Superoxide Dismutase (SOD)
Date:
June 29, 2005 10:54 AM
Most people know that antioxidants found in food are critical for health and longevity, but did you know that the human body has its own antioxidant defense system? Superoxide dismutase (SOD) is an internal antioxidant manufactured by the body as the first line of defense against free radical damage. Unfortunately, high levels of stress and exposure to environmental and dietary toxins can deplete our antioxidant stores, leaving us more susceptible to chronic health challenges. When we are young and healthy the body unleashes its own antioxidants, but as we age this internal antioxidant producing system declines and the body needs help. Source Naturals introduces GLISODIN POWER, an innovative approach to antioxidant supplementation. Scientific research shows that GliSODin® supports the body’s own production of superoxide dismutase. GLISODIN POWER is a patented, orally effective, 100% vegetable compound comprised of gliadin, a wheat protein extract bound to superoxide dismutase derived from canteloupe. Oxygen is required by your cells to generate energy, but it also contributes to oxidative stress or free radical damage, which is one of the primary causes of age-related damage to your cells and tissues. Free radicals have unpaired electrons that can damage living cells and compromise the proper function of tissues and organs. Antioxidants make free radicals stable by providing them with an additional electron. Unfortunately, now the antioxidant is missing an electron so, ironically, it becomes a free radical, which requires another antioxidant to donate an electron. Because this process starts a cascade of free radicals, scientists strongly recommend a broad range of antioxidants to minimize this negative effect. First Line of Defense There are two classes of antioxidants-external and internal. External antioxidants are supplied to the body by the foods we eat or the supplements we take. They include vitamins A, C and E, selenium, and other antioxidants found in fruits and vegetables. Internal antioxidants are naturally present in every cell of your body. The internal antioxidant defense system includes the enzymes superoxide dismutase (SOD), catalase and glutathione peroxidase. They are the first line of defense against oxidative stress. SOD transforms the superoxide radicals into ions that are less reactive. The superoxide radicals, which are byproducts of normal cell processes, can damage cells if their levels are not controlled. The other enzymes then transform the less reactive ions in a process called dismutation. The superoxide dismutase enzyme gets its name from this process. Research indicates that SOD plays an important role in protecting neurons from oxidative damage. Super Antioxidant: SOD SOD levels decline with age, while free radical production increases. SOD occurs naturally in barley grass, broccoli, Brussels sprouts, cabbage, wheat grass, melon and most green plants. Unfortunately, when taken orally the SOD enzyme is usually destroyed in the digestive process. GliSODin is a new form of SOD that withstands the digestive process and promotes SOD production by the body. This breakthrough technology combines a vegetable source of SOD extracted from melon with gliadin, a wheat protein. Scientific studies have shown that GliSODin promotes the natural production of SOD in the body. Research has also shown that it protects against oxidative stress and provides an optimal defense against free radicals. Wellness Revolution Innovative natural products such as GLISODIN POWER, are part of the Wellness Revolution. Taking personal responsibility for your health is at the heart of this revolution. Your local health food outlet is your source for nutritional education and quality products. Source Naturals is pleased to partner with these outlets to bring you the groundbreaking nutritional science of GLISODIN POWER.
References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=524) Basic Detox
Date:
June 10, 2005 04:08 PM
Basic Detox by Harriet Epstein , February 4, 2002 Basic Detox By Harriet Epstein Trying to stay healthy and clean in a dirty world can prove a difficult task. The rise of modern industry and agriculture has meant the widespread accumulation of toxins in our environment that can cause health problems. As Kenneth Bock, MD, and Nellie Sabin point out in their book The Road to Immunity (Pocket), "Fat soluble chemicals are readily absorbed by the body but are difficult to excrete. To be excreted, they must first be enzymatically converted into water-soluble substances. Some of them can't be converted at all." Bock and Sabin point out that a 1990 survey by the United States Environmental Protection Agency (EPA) that looked at people's tissues found that everyone the agency examined had styrene (a chemical used to make plastic) and xylene (a paint and gasoline solvent) stored in their bodyfat. Toxin Exposure The toxins that you encounter every day are not only present in air and water, but also may be found in food and medicines. If we eat beef that's been exposed to pesticides, those chemicals may be shunted into our bodyfat. Pesticide residues in fruits and vegetables may end up in a similar place. To cope with chemicals, the human body has evolved methods for detoxifying. When we breathe out we often release inhaled toxins. Other toxins are purged through urine, feces and sweat. One of the chief organs responsible for cleansing the body is the liver. This organ utilizes a pair of chemical pathways for breaking down and eliminating toxins. In our hectic, industrialized world, this flow of toxins can overwhelm the liver's ability to detoxify. In addition, the dual processes the liver uses to eliminate noxious substances may become unbalanced, allowing toxins produced by one pathway to build up to dangerous proportions. Languishing Liver Once liver function falters, toxic havoc ensues. Toxins may remain in the body, often stored indefinitely in bodyfat. The body's detoxifying systems may be swamped with toxins. In protecting the liver and enhancing its detox functions, many naturopathic practitioners recommend the herb milk thistle (silybum marianum). According to Steven Bratman, MD, and David Kroll, PhD, authors of the Natural Health Bible (Prima), milk thistle helps the liver cope with its toxic load. Consequently, milk thistle is frequently used in Europe for liver problems like jaundice. Bratman and Kroll point out that milk thistle "is one of the few herbs that have no real equivalent in the world of conventional medicine." As Lise Alschuler, ND, medical director at the Bastyr Natural Health Clinic, told Natural Digest, "Milk thistle protects the liver against toxic damage (and) helps prevent damage to the rest of the body." Toxin Zappers The compounds in milk thistle that help zap toxins, known as silymarin, protect the liver by binding with substances that would otherwise interact with the liver and slow its function. They also help the liver repair itself and regenerate new liver cells. As an extra bonus, silymarin acts as an antioxidant, protecting liver cell membranes from oxidative damage. Dandy Detox Dandelion has a place as another traditional treatment for toning the liver and boosting the body's filtration system. The leaves are a cornucopia of antioxidants and nutrients including B vitamins, vitamins A, C and D, plus boron, silicon, potassium, magnesium and zinc. They help detoxify by acting as a mild diuretic: they cause the body to eliminate excess fluid. But herbalists worldwide have found the compounds in dandelion root most useful for helping alleviate liver and gall bladder malfunction. (If you think you suffer these difficulties, consult your health practitioner.) Two unique and helpful natural substances found in dandelion root are chemicals called germacranolide and eudesmanolide. The root, according to the Natural Health Bible, has traditionally been used to speed up a sluggish or congested liver as well as detoxing the body by eliminating constipation. Research indicates dandelion root may stimulate bile flow (Arzneimittel -forschung 9, 1959: 376-378). Juniper berries (Juniperus communis), may also be taken with dandelion as a diuretic. This botanical, often used to combat urinary tract problems, is also an anti-inflammatory (Phyto Res 1, 1997: 28-31). Metal Problems Heavy metals rank as dangerous toxins unleashed by modern industry. As Michael Murray, ND, and Joseph Pizzorno, ND, explain in the Encyclopedia of Natural Medicine (Prima), metals like lead, mercury, cadmium, arsenic, nickel and aluminum can "accumulate within the (body) where they can severely disrupt normal function." Public health experts estimate at least one in five Americans has been a victim of heavy metal poisoning. Lead may be the most common villain. In your everyday life, you may be ingesting metals from your cookware, from pesticides, cigarette smoke, dental fillings, polluted fish, and chipping house paint. Signs that you may suffer from toxicity linked to heavy metals: Unusual fatigue, Persistent headaches, Unexplained muscle pains, Anemia, Ringing in the ears or dizziness and Tremors. Of course, if you think you suffer from heavy metal poisoning, you should see a knowledgeable health practitioner as soon as possible. Murray and Pizzorno recommend an array of precautions to protect yourself against heavy metals in the environment: Take a daily multivitamin and mineral. Take extra amounts of vitamin C and B-complex. Take amino acids that contain sulfur (taurine, cysteine and methionine) and high sulfur foods like onions and garlic (or supplements). (Consult your pharmacist of health practitioner before taking individual amino acids.) Consume water-soluble fibers like guar gum, oat bran, psyllium and pectin. Smooth Digestion In addition, Leo Galland, MD, in his book The Four Pillars of Healing (Random House) offers these tips for keeping your digestive tract functioning at top capacity: Add spices to your foods and consume garlic, onion, turmeric, rosemary and sage to aid digestion. Take supplements of lactobacil-lus acidophilus and lactobacillus plantarum, friendly bacteria that in-habit the large intestine. These microorganisms can help break down toxins and eliminate them. Use aspirin and ibuprofen as little as possible. They increase the permeability of the digestive system, allowing allergens and other problematic substances to enter the body. Do not use antacids. The stomach's acidic environment is designed to kill ingested bacteria and parasites. To fight digestive problems or heartburn, cut back on saturated fat; eat smaller meals. Chewing on calcium tablets after meals may help. Foods that can exacerbate heartburn include coffee, alcoholic beverages and very spicy foods. Dr. Galland also recommends not eating for four hours before bed. Environmental Free Radicals Detoxing the body may also require taking antioxidant nutrients to fight off what are called free radicals. Free radicals are caustic molecues thought to be involved in causing many chronic problems such as cancer and heart disease. Free radicals are created within the body and its cells every time a metabolic activity takes place. While the human body has developed its own mechanisms for defending itself against these byproducts of metabolism, exposure to pollution, radiation and other toxins may overburden the body's free radical burden. Scientists believe that taking extra antioxidant nutrients like vitamins C and E and carotenoids (natural substances found in many vegetarian foods) may help prevent damage by free radicals. Environmental oxidizing agents include ionizing radiation (from industry, sun, cosmic rays, x-rays) ozone and nitrous oxide (from auto exhaust) heavy metals (mercury, cadmium, lead) and cigarette smoke, along with other chemical and compounds from food, water and air. Free radicals are believed to play a role in more than sixty different health conditions, including the aging process, cancer and arteriosclerosis. (Proc Natl Acad Sci USA 1993;90:7915-7922). The good news? Reducing exposure to free radicals and increasing intake of antioxidant nutrients can shrink the risk of these health problems. Antioxidant focus "Antioxidants can't get rid of heavy metals and solvents," says Dr. Glidden, "but they do cut down on the damage they do while they're there. As toxins wander through your body, they generate metabolic reactions, resulting in free radicals. And anti-oxidants mop them up." The liver is the last line of defense in handling toxins; supplements help it regenerate itself. The body itself does produce enzymes like Superoxide dismutase (SOD) catalase, and glutathione peroxidase which can defend against and defuse many types of free radicals. Supplements of these compounds are also available to augment the body's supply. These building block nutrients include the minerals manganese, zinc, and copper for SOD and selenium for glutathione peroxidase. Many vitamins and minerals act as antioxidants. Dr. Crinnion recommends a multivitamin with "a lot of B, especially magnesium." Since chlorinated pesticides like DDT "rob the body" of B1 and Vitamin A, he says, it's a good idea to supplement these as well. In addition, acidophilus, a beneficial bacteria that grows in the digestive tract (and found in yogurt) may restore immunity hurt by pollutants. A study on women with recurrent vaginal candidiasis found that acidophilus cut their infections by 300% (Annals Int Med 1992; 116:353-357.) Another immunity enhancer, colostrum, a natural immune enhancer that promotes cellular repair (Food Res Intl. 1995, 28(1):9-16) can also help the immune system battle pollution. Vitamin C vs Pollution A study of vitamin's C's antioxidant properties, conducted by University of Buffalo epidemiologists, and presented at the Annual Meeting of the Society of Epidemiologic Research, revealed that people with higher levels of vitamin C in their blood serum have lower levels of a marker of oxidative stress. "It is well known that oxidative stress (cell damage caused by free radicals) plays a role in arteriosclerosis, cancer, pulmonary disease and other chronic conditions," said Holger Schunemann, M.D. a research assistant professor of social and preventive medicine at the University of Buffalo and lead author on the study. "In this population, vitamin C was negatively associated with oxidative stress, suggesting it may play a role in protecting against these diseases." Vitamin C is the "greatest antioxidant," says Dr. Crinnion. "It has even been shown to clear lead from the blood." Effective E A powerful fat-soluble antioxidant, Vitamin E scavenges free radicals protecting cells from oxidative damage. Vitamin E, "reverses toxicity of various toxic chemicals," says Dr. Walter Crinnion, "it is also a stabilizer of membranes." A study published in the American Journal of Clinical Nutrition regarding antioxidant vitamin supplementation and lipid peroxidation in smokers even indicates that an antioxidant-supplemented drink can reduce lipid peroxidation and susceptibility of LDL to oxidation in smokers and may ameliorate the oxidative stress of cigarette smoke. Dr. Glidden recommends E preferably in the form of mixed tocopherols )If you take blood thinners, check with your health practitioner.) Unfortunately, completely avoiding toxins in today's world is probably impossible. Civilization and toxic chemicals accompany each other hand in rubber-glove-encased hand. Still, with proper attention to nutrition and supplements to keep our bodies detoxifying, we can probably minimize health difficulties linked to these undesirables.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=275) Inflama Rest - Natural COX-2 Inhibitor for Joint Comfort
Date:
June 02, 2005 12:37 PM
It happens. You reach for something and feel a sudden discomfort. Your joints and muscles may feel tender from overuse. Inside, your cellular systems are out of alignment, resulting in lessened mobility. Source Naturals understands how difficult joint discomfort can be to live with. We are deeply committed to developing well-researched formulas that address the root cause of joint distress. Our Bio-Aligned Formulas™ bring alignment to multiple interdependent body systems. Only this type of indepth formulation can provide the long-term relief you are looking for. Regain your comfort with Source Naturals INFLAMA-REST. Unlike many products that contain just a few ingredients to offer temporary relief, INFLAMA-REST is a Bio-Aligned Formula™, scientifically designed to address aches. INFLAMA-REST goes deep to the underlying cause of joint discomfort. These systems include: inhibition of pathways involved in joint discomfort, joint and muscle function, DNA protection and antioxidant defense. Addressing Joint Comfort on a Deep Cellular Level Discomfort can come from many places. From your head to your toes there are many tissues that can become uncomfortable from everyday use. Joint discomfort starts when stress, such as tissue damage, causes an imbalance of the biochemical pathways on a deep cellular level. The body has its own “innate intelligence” encompassing more than just the thoughts in the brain. It consists of ongoing and complex chemical reactions regulated by a wide variety of enzymes and chemical messengers. These reactions can sometimes get out of balance – but you can control and inhibit key body chemicals that would otherwise lead to cellular irritation. For example, certain types of prostaglandins that regulate normal physiological functions such as blood flow, are maintained at low levels in all our cells under everyday conditions. In response to stress, a message is sent to the outer membranes of certain cells to convert their fatty acids into arachidonic acid, the raw material for prostaglandins. This stress also directs cells to produce Cyclooxygenase enzyme- 2 or COX-2. This enzyme converts arachidonic acid into Prostaglandin E2, a particular type of prostaglandin specifically responsible for irritation on a cellular level. The result: joint discomfort. But that doesn’t have to happen. By supporting inhibition of the culprit COX-2, you can decrease Prostaglandin E2 production to bring your joint tissues back into a healthy and comfortable balance. INFLAMA-REST includes herbs that support inhibition of COX-2 in a variety of pathways. Ginger, turmeric and green tea all support direct COX-2 inhibition. But there are other places in our biochemical communication system where COX-2 production can be inhibited. Two additional factors that lead to COX-2 production are nitric oxide and the enzyme that produces it, nitric oxide synthase (iNOS). Nitric oxide is a free radical associated with cell growth and regeneration, blood vessel elasticity and COX-2 enzyme production. Resveratrol, rosemary and turmeric support iNOS inhibition, thus inhibiting your body’s over-production of nitric oxide and the COX-2 enzyme. A related irritation factor is also one of the latest scientific discoveries in cellular health - Nuclear Factor kappa-B (NF-kappa-B). NF-kappa-B works at the DNA level – at the blueprints of cells. When activated, this factor controls the genes that regulate cell growth, differentiation and regeneration. And blocking this factor is also associated with inhibition of both COX-2 and iNOS enzymes. Stinging nettle, milk thistle and Chinese Skullcap all block unhealthy NF-kappa-B activation in your body and thereby help support COX-2 inhibition. Cytokine Inhibition Compounds called cytokines, or interleukins, can also stimulate biochemical pathways leading to joint discomfort. Cytokines are chemical messengers produced by the immune system to regulate defensive activity when they are stimulated. For example, cytokines are released by macrophages in response to stimuli such as tissue damage. This results in rapid escalation and amplification of cell number and response. Constant stress can shift this system out of balance, resulting in tissue discomfort. Bringing these compounds back into balance can preserve your short-term comfort and longterm health. INFLAMA-REST contains curcumin from the spice turmeric. Curcumin assists the body’s inhibition of cytokine activity to support reduced cellular irritation. And Bioperine®, which is derived from black peppercorns, is added to assist curcumin assimilation. Stress Response: Joints and Muscle Support Inhibition of chemical messengers involved in joint discomfort is just part of a Bio-Aligned strategy for relieving discomfort. Research has shown that emotional stress, particularly long-term, can directly affect the body and set in motion mechanisms that cause physical discomfort. Ashwaganda and Chinese Skullcap (S. baicalensis) are herbs that help modulate the body’s response to stress and may help ease aches and discomfort. Boswellia, ginger, quercetin, milk thistle, feverfew, Oregon grape root and bromelain (an enzyme found in pineapples) provide additional soothing relief to your cells and tissues. Essential nutrients are also vital to maintaining your joint comfort. The tocotrienol forms of vitamin E, along with selenium, protect cell membranes from lipid-based free radicals. Magnesium aids energy metabolism in muscles and can reduce tenderness as well as muscle spasms. Zinc is essential for normal cellular repair mechanisms such as wound healing and is important for the growth and maintenance of connective tissue. And manganese works to protect cells from oxidation and to build healthy connective tissue as well, an essential component of healthy joints and muscles. Protecting Your DNA To reduce cellular irritation, you need to protect the DNA in your cells. DNA is the blueprint for all of the molecules in the body. If your DNA is altered or damaged, then needed molecules may not be produced, leading to short-term and eventually long-term damage. Curcumin, from turmeric, has been shown in in-vitro studies to protect DNA against strand breakage. Quercetin has also been shown to directly protect DNA against strand breakage and base oxidation from free radicals and damaging chemicals, according to recent in-vitro research. Providing Powerful Antioxidant Cellular Protection Antioxidants are selfless bodyguards of your cells. They donate their own electrons to stabilize free radicals in your body. Thus, antioxidants absorb the damage that would have been done to your tissues. Some regulatory chemicals, such as Nitric oxide, are powerful free radicals and oxidants. Oxidants also activate NF-kappa-B. Tissues, lipids, proteins and DNA are extremely sensitive to oxidation. Quercetin, milk thistle, turmeric, ginger, rosemary, vitamin E and resveratrol are all antioxidants that help modulate the activity of these compounds as well as protect cells and tissues from damage. Plus, Superoxide Dismutase (SOD), one of the most important enzyme antioxidants found in your body, has been added in a new cutting-edge form. The vegetarian SOD used in INFLAMA-REST is attached to Gliadin, a wheat protein, that has demonstrated significantly better absorption than SOD alone. Six Lifestyle Strategies for Fewer Aches
Inhibition of COX-2: Turmeric, Ginger, Chinese Skullcap, Green Tea, Resveratrol, Boswellia, Silymarin, White Willow Inhibition of Cytokine Turmeric, Stinging Nettle, Feverfew Inhibition of Rosemary, Green Tea, Resveratrol, Turmeric, Quercetin, Chinese Skullcap NF-kappa-B Activation Silymarin, Chinese Skullcap, Stinging Nettle, Rosemary, Resveratrol Stress Response: Ashwaganda, Magnesium, Chinese Skullcap, Oregon Grape, Feverfew, White Willow DNA Protection Turmeric, Quercetin, Rosemary Antioxidant Defense Silymarin, SOD Gliadin, Turmeric, Rosemary, Tocotrienols, Resveratrol, Ginger, Selenium, Manganese, Zinc Prostaglandin & Leukotrine Synthesis Joint & Muscle Support Inhibition of Nitric Oxide Synthesis Production
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=158) Garlic Inhibits Free Radical Generation and ...
Date:
May 12, 2005 12:45 PM
Garlic Inhibits Free Radical Generation and Augments Antioxidant Enzyme Activity in Vascular Endothelial Cells
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=39) Guggul – New Benefits for Heart Health 
Date:
May 11, 2005 09:00 PM
Gum Guggul–New Benefits for Heart Health from an Age-Old Herbby Richard Conant, L.Ac., C.N.The 1990's have seen a growing interest in herbs from India's ancient Ayurvedic tradition. One Ayurvedic herb in particular, "gum guggul," stands at the forefront, thanks to its rather remarkable benefits for the heart and cardiovascular health. A relative of myrrh and frankincense, gum guggul is a resin tapped from India's Commiphora mukul tree. Known more commonly in the Far East as simply "guggul," the herb has proven to be one of the most effective natural cholesterol-lowering agents ever discovered. Cholesterol reductions with guggul can be twenty percent or higher, and the herb also raises HDL, the more beneficial form of cholesterol. Studies also show guggul may help prevent atherosclerosis, by retarding the formation of fatty, cholesterol-laden deposits in blood vessel tissues. Recent research on guggul has revealed that guggul also blocks the oxidation of LDL cholesterol, by acting as an antioxidant. LDL, which carries cholesterol from the liver to the rest of the body, is generally regarded as a key element in the development of atherosclerosis. But only when it is oxidized by free radicals does LDL accumulate in arteries. It its unoxidized or "native" state, LDL is more or less benign. Checking LDL oxidation is vital to keeping blood vessels free of plaque.1 (This is one of the major reasons why antioxidants are so important.) Guggul, by both lowering blood cholesterol and acting against LDL oxidation, now stands out as one of the world's most valuable herbs for heart health. Guggul first caught the attention of the scientific world in1966, thanks to an Indian medical researcher who submitted a doctoral thesis on gum guggul.2 Her interest had been kindled by references to the herb in a centuries-old Ayurvedic text. Apparently, poor cardiovascular health and atherosclerosis were a problem back then just as they are today. Translated from Sanskrit, this text describes, in elegant detail, a condition called "coating and obstruction of channels." The cause, according to the ancient writers? Faulty metabolism due to overeating of fatty foods and lack of exercise. Death was said to be the end result of leaving this condition uncorrected. The recommended treatment plan emphasized diet and herbs, chiefly gum guggul.3 References to guggul in ancient literature actually go back even farther. The herb is mentioned in the Vedas, the holy scriptures of India believed to be anywhere from 3,000 to 10,000 years old. One stanza is translated as follows: "Disease (consumption) does not afflict and the curse never affects whom the delicious odor of the healing Guggul penetrates (spreads). The diseases also flee away in all directions from him like horses and deer, O Gugulu! Either born from Sindhu or from the sea. I chant your name for the removal of diseases."3 Struck by the obvious similarity between "coating and obstruction of channels" and atherosclerosis, the Indian researcher decided to study gum guggul's effect on blood fats in rabbits. Over a two-year period, the animals were fed hydrogenated vegetable oil to artificially raise their cholesterol levels. Guggul was administered to one group of rabbits, while the rest served as controls. At the end of the study the rabbits given guggul had normal cholesterol and blood lipid levels. Their arteries showed no fatty streaks or plague deposits. This caught the attention of the Indian scientific community, and numerous clinical trials ensued, both on animals and humans. In study after study, guggul consistently produced substantial reductions in cholesterol and triglyceride levels, while raising HDL. The active ingredients in guggul are a group of natural plant sterols. Among these, substances called "guggulsterones" are the most important ingredients for the cholesterol and blood fat lowering properties of guggul, with the other sterols acting as a synergistic supporting cast.4 A number of mechanisms are suggested, although not definitely proven, for how the herb works; these include reducing the synthesis of cholesterol in the liver, enhancing cholesterol removal from the gut, stimulating thyroid function and increasing the number of receptors in the liver for uptake of LDL.3,5 Guggul extracts are now standardized for guggulsterone content. The herb naturally contains about 2 percent guggulsterones. Quality extracts contain a minimum of 2.5 percent, which assures the user is getting a product potent enough to produce results. Since the late 1980's clinical trials have used the standardized extract.6,7,8 The product is readily available in the U.S. The ability of guggulsterones to prevent oxidation of LDL was discovered in a 1997 study done by scientists at the Central Drug Research Institute in Lucknow, India.9 This study sheds light on how guggul works against "coating and obstruction of channels." Remember that oxidized LDL forms the plaque that coats and eventually obstructs blood vessels. The researchers mixed LDL from human blood with a free radical promoting agent, either alone or in combination with guggulsterones. Samples were then analyzed for the presence LDL oxidation byproducts. The results showed that guggulsterones strongly protect LDL from being oxidized. Guggulsterones block the formation of hydroxyl radicals, a potent type of free-radical that attacks cell membranes. Guggulsterones may also help keep the heart muscle itself healthy. When the heart muscle is deprived of oxygen, a condition known as "myocardial ischemia," it can be severely damaged by free radicals. The body tries to counter this with SOD, a key enzyme present in cells that neutralizes free radicals. SOD levels are significantly reduced in damaged heart tissues. Guggulsterones have been found to reverse this decrease by more than two-fold.10 Like the writer of that age-old verse found in the Vedas, contemporary herbalists hold gum guggul in the highest regard. Backed as it is by scientific research linked to centuries of traditional use, gum guggul has a bright future as a natural resource for maintaining normal cholesterol and blood fats, and for protecting heart health. References 1. Heinecke, J.W. Free radical modification of low density lipoprotein: mechanisms and biological consequences. Free Radical Biology & Medicine 1987;3:65-73. 2. Satyavati, G.V. Effect of an indigenous drug on disorders of lipid metabolism with special reference to atherosclerosis and obesity (Medoroga) M.D. thesis (Doctor of Ayurvedic Medicine). Banaras Hindu University, varanasi, 1966. 3. Satyavati, G. Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii). Economic and Medicinal Plant Research 1991;5:47-82. 4. Dev, S. A modern look at an age-old Ayurvedic drug-guggulu. Science Age July 1987:13-18. 5. Singh, V. et. al. Stimulation of low density lipoprotein receptor activity in liver membrane of guggulsterone treated rats. Pharmacological Research 1990;22(1):37-44. 6. Nityanand, S., Srivastava, J.S., Asthana, O.P. Clinical trials with gugulipid. J. Ass. Physicians of India 1989;37(5):323-28. 7. Agarwal, R.C. et. al. Clinical trial of gugulipid-a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:626-34. 8. 'Gugulipid' Drugs of the Future 1988;13(7):618-619. 9. Singh, K., Chandler, R. Kapoor, N.K. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytotherapy Research 1997;11:291-94. 10. Kaul, S. Kapoor, N.K. Reversal of chnages of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats. Indian Journal of Experimental Biology 1989;27:625-627.
--
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=27) | ||||||||||||
.jpg)
Do you suffer from inflammation? If so, you're not alone. Inflammation is a common problem that can cause pain and discomfort in the body. Fortunately, there is a natural remedy that can help: curcumin. Curcumin is a compound found in turmeric that has powerful anti-inflammatory properties. We will discuss the benefits of curcumin and how to add it to your diet. 
