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Huge 400 page scientific report concludes marijuana effectively treats chronic pain
January 26, 2017 10:59 AM
One of the most controversial topics in recent history is the question of whether or not marijuana can treat chronic pain. The question then arises whether or not the information contained in the report will actually benefit the pro-marijuana movement overall is an open question, since the findings are a mix of positive and negative regarding the use of marijuana and its impact on public health. This information may or may not play an important role.
"The researchers reported evidence associating marijuana to an increased risk of automobile accidents, lower birth weights for babies whose mothers smoked cannabis during pregnancy, and a link between marijuana smoking and bronchial problems."
Free Radicals And Cancer, How Do I Combat Free Radicals?
October 12, 2011 01:09 PM
Free Radicals Overview
Free radicals, just the very sound of those words are so dreaded in so many consultation clinics around the country today, this substance has mainly been linked to cancer and its proliferation but what else is there to know about free radicals and cancer. This is what we will be looking at as we go along this article. These free radicals are organic molecules which are primarily the cause for aging, damaged tissues, and a variety of diseases. The main property that causes them to bind with other molecules in the body there by causing damage is because it is unstable. This is the non-stop process that these molecules will do, destroy cells, takes away its vigor and initiate this pro aging process. In a way it is the natural order of things, our world is filled with so many unstable molecules and just like us, there survival instincts kick in and they have to keep stable. Outside the body, that’s all good, no harm for us, but when the same process occurs inside that’s where our own survival instincts come in and helps us think of ways to stop this process of degeneration. With this degeneration process of cells being damaged, it is not far fetch to see these free radicals as the cause of some disease most especially Cancer.
Cancer has been a close second as the top killing disease in America for the past few years now, 2011 is not over yet so there is no ranking out but my guess is, the top 2 will most likely be the same with number one still being heart disease. Cancer is basically characterized by out of control cell growth. There are many classifications of cancer and one thing remains constant, it is characterized or named based on what type of cells it began to damage to cause the eventual cancer. For many of us out there what we do not want to here are malignant tumors in the body and this can occur based on 2 things, when cancerous cells spreads around the body through the bloodstream which is often referred to as an invasion process and the second is when the cancerous cells divide and grow leaving tissues metastasized in a process called mestastasis. Tumors grow and uncontrollably which are lumps of masses that interfere with our normal bodily functions and causes systems to crash like our digestive and nervous systems just to name a few.
Antioxidants has been well known to be one of the best ways to fight cancer, present in many foods, these molecules does its handy work against cancer by going to the source. More research needs to be done in its healing effects but as an effective treatment it has been proven to be an integral part in minimizing further proliferation of damaged cells. Antioxidants have been shown to have an amazing characteristic against free radicals and that it plays an integral role in killing these cell damaging molecules in the body.
List of antioxidants:
This by far a complete list, but it will get you get started with an antioxidant program to help prevent disease caused by free radical damage.
What Vitamins And Minerals Are For Mental Alertness?
August 29, 2011 10:33 AM
There are many vitamins and minerals which can help improve the health and functioning of the nervous system. Vitamins and minerals are significantly involved in many biological processes of the body. It influences the activities of the organs of the body including the brain. In fact, deficiencies on vitamins and minerals may result to psychological or even psychiatric symptoms in certain individuals. People with psychiatric problems are also prescribed with vitamin and mineral supplements which serve as one of its conventional treatment.
The vitamins and minerals which are good for the improvement of brain function and improvement of mental alertness are the following:
1. THIAMINE OR VITAMIN B1. Generally, insufficient amount of this enzyme may result to mild psychiatric symptoms. Studies revealed that people with inadequate amount of this vitamin has the symptoms of fearfulness, anxiety, depression, agitation and behavioral instability. This vitamin is necessary for the activity the body’s enzyme called pyruvate dehydrogenase. This enzyme is required for the conversion of pyruvate to acetyl – coenzyme A. If pyruvate is not catalyzed into acetyl – coenzyme A, the excess pyruvate in the body might be converted into lactate which can cause muscle pains and also psychiatric symptoms such as anxiety. Deficiency of this vitamin must be suspected when the person is alcoholic or malnourished.
2. RIBOFLAVIN OR VITAMIN B2. This vitamin is closely associated with major depression in relation to oxidative stress. Riboflavin is required for the metabolism of protein, fats and carbohydrates. The building blocks of these macronutrients are important for the maintenance of brain health and proper functioning of the nervous system. It can improve the energy levels and functioning of the brain, thus improving an individual’s mental alertness.
3. PYRIDOXINE OR VITAMIN B6. Studies show that low level of vitamin B6 is directly related to depression. Inside the body, pyridoxine is converted into its biochemical active form called pyridoxal phosphate which is important for mental alertness and brain functioning. Pyridoxine acts as a coenzyme involved in the synthesis of brain chemicals such as serotonin, dopamine and gamma aminobutyric acid (GABA). This vitamin is also involved in the metabolism of carbohydrates and amino acids which are essential for boosting energy levels.
4. COBALAMIN OR VITAMIN B12. Deficiency of this vitamin is closely related to decrease mental functioning. Vitamin B12 is a cofactor of the enzyme methionine synthase which is important in the conversion of homocysteine to methionine. This is required for the production of energy in fatty acids and proteins which is important for the methylation reactions of brain chemicals.
5. VITAMIN C. This vitamin is considered to be a cofactor of the neurotransmitter dopamine and is involved in the conversion of dopamine to norepinephrine. These brain chemicals are important for the maintenance of proper mental alertness.
6. FOLATE. Decreased mental alertness and depression is a common symptom of low levels of folate in the body. This mineral is involved in the methylation and synthesis of DNA. It is important for the development of brain function and improvement of mental alertness.
7. MAGNESIUM. This mineral is involved in many reactions of the body. Individuals with decreased mental alertness are found to have low levels of magnesium in their cerebrospinal fluids.
8. ZINC. This is a mineral which is important in the catalyses of many enzyme sin the body. It is found in high amount in the brain which is important for nervous activities.
Gymnema Sylvestre Leaf Extract
September 16, 2009 11:31 AM
Gymnema has been used for centuries throughout the world for medical purposes. Only recently has it gained popularity in the Western world. The herb grows naturally in Africa and India. It is traded all over the world. Generally, the leaves are the part used. However, the root seems to supply some medicinal properties as well. The plant is a vine-like woody plant that can be found growing on bushes and small tress. It is a member of the milkweed family.
Gymnema has been used by Ayurvedic physicians to treat ailments such as stomach problems, diabetes, and urinary disorders for more than two thousand years. Early physicians found that chewing some of the leaves helped an individual to lose a taste for sweets. Modern scientific research has confirmed that gymnemic acid, the active ingredient, blacks the taste of sugar and blocks sugar’s absorption by the body. It is also thought the gymnema suppresses the taste of saccharin and clycamate, which are two common artificial sweeteners. A study done in 1986 also suggests that this herb is able to significantly increase liver and pancreatic function. This ability is promising for diabetes, obesity, hypoglycemia, allergies, anemia, and osteoporosis.
This herb is used for blocking the passages that sugar is normally absorbed. This prevents calories from being absorbed and blood sugar levels are not so drastically affected. The herb is also thought to block the body’s desire for sweets. One study found a link between the taste buds and the absorption of sugar in the intestines. Because gymnemic acid, found in gymnema, has a molecular structure similar to sugar, these molecules can fill in the receptor locations on the taste buds temporarily, preventing the taste buds from being activated by the sugar eaten. The same basic thing happens in intestines, as the structure of tissue in the intestines is similar to the taste-bud structure that detects sugar. The gymenmic acid fills in the receptors in the intestines, which prevents absorption.
One of the most promising uses of gymnema may be in cases of diabetes. Research on animals has found that a reduction of blood sugar levels occurs after the consumption of gymnema extract. The herb may help to reduce the amount of insulin needed by diabetic individuals on insulin therapy. The herb is found in combinations that are often associated with controlling blood glucose levels and metabolism. Gymnema seems to be successful in some cases of diabetes. Additionally, the herb has been found to actually improve both liver and pancreatic function.
Over time, this herb has proven to be a nontoxic remedy. Gymnema is used for many conditions. Among these are diabetes, digestion, urinary tract problems, obesity, hypoglycemia, allergies, anemia, cholesterol, and hyperactivity. Gymnema may be a useful remedy in the concern over sugar and sugar-related problems, along with many other medical ailments.
In short, the leaves and roots of the gymnema plant are used to provide antiperiodic, diuretic, and stomachic properties. Primarily, this herb is extremely beneficial in dealing with diabetes, hyperactivity, and hypoglycemia. Additionally, gymnema is very helpful in treating allergies, anemia, high cholesterol, gastric disorders, indigestion, obesity, and weight conditions. For more information on the many beneficial effects provided by gymnema, please feel free to contact a representative from your local health food store.
The Awesome Foursome: Coenzyme Q10, D-Ribose, L-Carnitine, and Magnesium
May 18, 2007 01:06 PM
The Awesome Foursome: Coenzyme Q10, L-Carnitine,
The “Awesome Foursome” of Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium helps our hearts metabolize energy more efficiently and protects them from the stress of cardiovascular disease. This powerful combination of nutrients goes directly to the basic biochemistry of cellular energy metabolism. Now let’s take a closer look at how Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium work in synergy to promote cardiovascular health.
Energy Recycling through the Electron Transport Chain
Coenzyme Q10 is a powerful antioxidant that helps protect the mitochondrial membrane, mitochondrial DNA, and cell walls from free-radical attack. But its most important function in the body is its central role in energy metabolism.
Most – about 90 percent – of the ATP used by cells is recycled as food (fuel) and oxidized in the mitochondria. Fatty acids, carbohydrates, and, occasionally, proteins are carried across the mitochondrial membrane and enter the Krebs’ cycle, moving from step to step and spinning off electrons. These electrons are then handed off to the electron transport chain, where, in the presence of oxygen, the energy from the electrons is captured as a phosphate group is added to ADP to form ATP. This recycling of ATP is called oxidative phosphorylation, and the by-products of these pathways are CO2 and water.
In this fashion, Coenzyme Q10 acts as a gatekeeper of electrons, making sure they are carried to just the right place to pass on their life-giving energy.
What is critical, however, is the simple fact that without Coenzyme Q10 the electron transport chain would totally break down. And since the electron transport chain is (by far!) the largest contributor to cellular energy turnover, its loss would be catastrophic. It is also important to know that there has to be an excess of Coenzyme Q10 in the mitochondria to be maximally effective. Having just enough isn’t sufficient to do the job properly, and having a deficiency seriously affects the mitochondria’s ability to supply the cell with energy.
Cellular stress can cause Coenzyme Q10 deficiency, which places a severe strain on Coenzyme Q10 availability. People with heart disease, hypertension, gingival disease, Parkinson’s disease, and the other disorders we’ve discussed are known to be deficient in Coenzyme Q10. Whether these deficiencies are the cause or the effect of these varied medical problems, the end result is that they sap the life out of their mitochondria and reduce their energy supplies. You see, Coenzyme Q10 cannot function properly if electrons are not coming out of the Krebs’ cycle, and the Krebs’ cycle won’t work without the fuel that’s transported into the mitochondria by L-Carnitine.
Transporting the Cellular Energy Fuel
Fatty acids are the preferred energy fuel for hearts and most other cells in the body. L-Carnitine facilitates the beta oxidation of fatty acids as energy fuel. And since fatty acids are the preferred fuel for energy recycling in cells, this action is critical to cell and tissue function. Unfortunately, L-carnitine is deficient in people with heart disease, peripheral vascular disease, lipid metabolic disorders, mitochondrial disorders, and many other disease syndromes we reviewed earlier. This L-carnitine deficiency disrupts the normal metabolism of fatty acids, reducing available energy supplies and leading to the accumulation of toxic by-products of fatty acid metabolism. L-carnitine supplementation revives fatty acid metabolism and restore normal mitochondrial function. But even this powerful improvement in cellular energy metabolism cannot up for the energy drain that comes from the loss of energy substrates caused by low oxygen delivery to the tissue. Only D-Ribose can do that.
Rebuilding the Cellular Energy Pool
As long as cells and tissues have plenty of oxygen, the pool of energy substrates in the cell remains high. And as long as there is enough L-carnitine and Coenzyme Q10 available, the process of energy utilization and supply can proceed unimpeded. However, the cellular supply of oxygen can be restricted by acute or chronic heart disease, peripheral vascular disease, any number of skeletal – or neuromuscular diseases, or even high-intensity exercise.
When cells are deprived of oxygen the mitochondrial energy turnover becomes inefficient. Remember, oxygen is required to let the oxidative pathway of energy recycling work properly. If the mitochondria are not able to recycle energy efficiently, cellular energy supply cannot keep pace with demand. But the cell has a continuing need for energy so it will use all its ATP stores and then break down the by-product, adenosine diphosphate (ADP), to pull the remaining energy out of this compound as well. What’s left is adenosine menophosphate (AMP). Since a growing concentration of AMP is incompatible with sustained cellular function it’s quickly broken apart and the by-products are washed out of the cell. The net result of this process is a depletion of the cellular pool of energy substrates. When the by-products of AMP catabolism are washed out of the cell, they are lost forever. It takes a long time to replace these lost energy substrates even if the cell is fully perfused with oxygen again.
Ribose is the only compound used by the body to refill this energy pool. Every cell in the body has the capacity to make ribose, but hearts, muscles, and most other tissues lack the metabolic machinery to make ribose quickly when the cells are stressed by oxygen depletion or metabolic insufficiency. Ribose is made naturally in the cells from glucose. In stressed cells, however, glucose is preferentially metabolized for the energy turnover and is not available for ribose synthesis. So when energy pools are drained from stressed cells, the cells must first wait for the slow process of ribose synthesis before they can begin to replace their lost energy stores.
Acute ischemia, like that which takes place during a heart attack, heart surgery, or angioplasty, drains the cell of energy. Even when oxygenated blood flow returns, refilling the energy pool may take ten or more days. But when oxygen deprivation is chronic, or when energy metabolism is disrupted by disease, there may be so much continual strain on the energy supply that the pool can ever refill without the assistance of supplemental ribose. Conditions like ischemic heart disease or congestive heart failure fall into this category. In these situations, supplementing the tissue with exogenous ribose is the only way the cell can keep up with the energy drain.
Switching on the Energy Enzymes
Magnesium is an essential mineral that's critical for energy requiring processes, in protein synthesis, membrane integrity, nervous tissue conduction, neuromuscular excitation, muscle contraction, hormone secretion, maintenance of vascular tone, and in intermediary metabolism. Deficiency may lead to changes in neuromuscular, cardiovascular, immune, and hormonal function; Impaired energy metabolism; and reduced capacity for physical work. Magnesium deficiency is now considered to contribute to many diseases, and the role for magnesium as a therapeutic agent is expanding.
Magnesium deficiency reduces the activity of important enzymes used in energy metabolism. Unless we have adequate levels of magnesium in our cells, the cellular processes of energy metabolism cannot function. Small changes in magnesium levels can have a substantial effect on heart and blood vessel function. While magnesium is found in most foods - particularly vegetables - deficiencies are increasing. Softened water and a trend toward lower vegetable consumption are the culprits contributing to these rising deficiencies.
Supporting the Links in The Energy Cycle Chain – the Synergy
Clearly, each membrane of the “Awesome Foursome” is fundamental to cellular energy metabolism in its own right. Each plays a unique and vital role in supplying the heart with the energy it needs to preserve its contractile force. Each is independently effective in helping hearts work through the stress of disease. And while each contributes immeasurable to the energy health of the cell, in combination they are unbeatable. Allow me to reiterate the step-by-step, complicated cellular processes involved to be sure that you really understand the rationale for using these nutrients.
The cell needs a large, sustained, and healthy pool of energy to fuel all its metabolic functions. Contraction, relaxation, maintenance of cellular ion balance, and synthesis of macromolecules, like proteins, all require a high energy charge to carry their reactions to completion. The energy pool must be preserved, or these fundamental cellular functions will become inefficient or will cease to operate altogether. To keep the pool vibrant and healthy, the cell needs ribose. But even with supplemental ribose, the cell needs the efficient turnover of its energy stores to balance ongoing energy utilization with supply. That’s where CoQ10 and L-carnitine come into play.
The converse is also true. Even if the cell is fully charged with energy, cellular energy supply will not keep pace with demand if the mitochondria are not functioning properly. CoQ10 and L-carnitine work to keep mitochondrial operations running at peak efficiency, and one side cannot work effectively without the other. Even though CoQ10 and L-carnitine can make the energy turnover mechanisms work more efficiently, they cannot increase the cell’s chemical driving force, and their action will be only partially effective. Ribose on the other hand, can keep the energy pool supplied with substrate, but the value of energy pool repletion cannot be fully realized if the substrate cannot be maximally utilized and recycled. Ribose fills the tank; CoQ10 an L-carnitine help the engine run properly.
Magnesium is the glue that holds energy metabolism together. By turning on the enzymes that drive the metabolic reactions, magnesium allows it all to happen.
These four nutrients must be utilized by cardiologists and other physicians as they treat patients day-to-day. On my own journey, using Coenzymes Q10 for two decades, L-carnitine for more than ten years, D-Ribose for two years, and magnesium equally as long, I’ve seen this “Awesome Foursome” reduce suffering and improve the quality of life for thousands of patients.
The future of nutrition in conventional medicine is very bright, although the integration of nutritional supplements has been a slow and, at times, lonely process.
L-carnitine and Coenzyme Q10 are finally gaining the recognition they deserve. D-Ribose is emerging as a new player in the complex understanding of metabolic cardiology, and doctors are beginning to discuss the important role of magnesium deficiency in heart patients. As a practicing cardiologist for over thirty years, I see metabolic cardiology as the future for the treatment of heart disease and other complex disease conditions, as well.
March 27, 2006 06:23 PM
If there’s one truth to be told about the natural products industry, it is this. We will never have a shortage of companies claiming to be the best. It happens so often in fact, that distinguishing the quality from the questionable has become an exhausting task all in itself. After all, making claims is easy. What’s challenging, however, is supporting these claims with something concrete.
As no stranger to recognition, NOW takes pride in every honor that is bestowed upon us. And yes, over the past year, we have been blessed in many ways. Nothing, however, can match the sense of reward that comes from having our efforts, values and commitment to human wellness acknowledged by our peers, colleagues and valued customers. It is with the most sincere gratitude that we are once again able to share these with you.
Vitamin Retailer Magazine’s 2005 Vity Awards Every Spring, Vitamin Retailer Magazine recognizes the most outstanding dietary supplements, and honors the recipients with a Vity Award. The winning products are selected based on a number of criteria. This year, three NOW products were awarded 1st place honors.
The first was presented in recognition of our MSM 1000 mg. This marks the third consecutive year that we’ve watched our MSM excel in this category. Next was the award for Vitamin E, which went to our Natural Vitamin E-400 mixed tocopherol formula. Like MSM, this was also awarded 1st place st place for the third year in a row. Finally, the award for “Best Calcium”, which was given to our Calcium Citrate. With the calcium category regarded as one of the most competitive, taking top honors is an accomplishment that we’re all very proud of. Whole Foods Magazine Natural Choice Winner Best Sports Supplement
It should come as no surprise to anyone that there are literally hundreds of protein formulas available. When it was announced that our line of Whey proteins had earned the title of “Best Sports Supplement” from Whole Foods Magazine, we were truly honored to be selected as one of their Natural Choice winners.
Each year, Whole Foods Magazine evaluates hundreds of products, selecting only those that meet their demanding standards. Our Sports division has worked tirelessly to perfect our Whey proteins, and this award is a true testament to the efforts they have put forth. NOW is one of the very few companies that offers a line of 100% natural proteins, free of artifi cial sweeteners. Accordingly, this is an honor that we’re especially proud of. Nutrition Business Journal’s Lifetime Leadership Award, Elwood Richard
Nutrition Business Journal recently honored NOW founder Elwood Richard, with their prestigious Lifetime Leadership Award. Mr. Richard has been an active member of the natural products business since 1960 and is a strong advocate for both science and quality. He co-founded the NNFA standards committee, and sponsors industry organizations such as Citizens for Health, NNFA, ABC, AOAC and AHPA among others. His hard work, vision and commitment have inspired our entire organization
in supporting independent retailers, producing quality products and taking proactive measures towards environmental preservation.
Nutrition Business Journal’s Business Achievement Award, Environment of Sustainability In addition to the award presented to Elwood Richard, NOW was also the recipient of the NBJ Business Achievement Award for Environment of Sustainability. This honor is presented to businesses who have consistently participated in both internal and local initiatives to make positive environmental impacts. Notably, our recycling program has reduced waste output by over 50%. NOW FOODS Vitamins also conducts employee training programs, supports community conservation efforts and hosts volunteer workdays to plant vegetation, remove litter and control lakeside erosion in a local forest preserve. These actions have earned us a number of community service awards from several local recreation organizations. Finally, we help support environmental organizations, including The Nature Conservancy and World Wildlife Fund.
AOAC adopts NOW Glucosamine Method
NOW Foods’ glucosamine HPLC method has passed the AOAC’s 2-year validation process to become the fi rst offi cial method for testing the standards of this popular joint health ingredient. It was selected by the expert review panel in April of 2003 as the “best method for further laboratory validation”. It will be published in the Journal of AOAC International and become available to the industry this summer, 2005. “Having NOW’s method for glucosamine become the offi cial AOAC method is a testament to the expertise of our staff, our focus on the science, and our commitment to quality,” said Michael Lelah, technical director of NOW Foods.
DuPage County Forest Preserve District’s Shooting Star Award.
The DuPage County Forest Preserve District of Illinois recently presented NOW Foods their Shooting Star Award at their annual Forest Preserve District volunteer banquet. This award recognizes the long-term efforts that our entire organization has made in order to improve and support the quality of the East Branch Forest Preserve in Glendale Heights, IL. This is also the fi rst time that the District has given this award to a company. As the primary recipient, we look forward to furthering our environmental efforts.
Recapping our 2004 Achievements
Eight 1st Place Vity Awards, from Vitamin Retailer Magazine
United States Department of Commerce Excellence in Export Achievement Award
Nutrition Business Journal’s Effort on Behalf of Industry Award Consumerlab.com Top Rated Brand in Health Food Stores based on Customer Satisfaction Natural Nutritional Foods Association (NNFA) Crusader Award, Elwood Richard Vitamin Retailer Magazine Manufacturer of the Year (2003)