Search Term: " ALA "
Alpha lipoic acid (ALA) treats back pain naturally: Research
April 13, 2019 11:15 AM
Studies of chronic pain sufferers that have been dealing with pain over a twelve week span have shown promising success by consuming alpha lipoic acid (ALA) supplements. By taking 600 mg per day, patients saw a large decrease in the amount of pain that they were suffering due to the consumption of the ALA pills. Researchers hope that the success of ALA in correlation to chronic lower back pain could give patients the opportunity to rely on more natural methods as opposed to opiates.
"If you suffer from chronic lower back pain, there is hope beyond a life of just taking pharmaceutical painkillers all the time to cope with the agony."
Read more: https://www.naturalnews.com/041571_alpha_lipoic_acid_back_pain_natural_treatment.html
How much omega-3 should you take each day?
March 27, 2019 10:28 AM
Many of us are well aware of the benefits surrounding omega-3 fatty acids, but exactly how much should we take on a routine basis in order to experience the most potent advantages? To receive benefits such as improved heart health, enhanced cognitive function, and inflammation reduction, people should be consuming 250 grams each day. This recommendation excludes pregnant women and children who should have around 300 grams each day due to their brains still being at a developmental milestone.
"DHA is essential for the eyes, brain and sperm cells. EPA is beneficial in reducing inflammation in the body."
Read more: https://timesofindia.indiatimes.com/life-style/food-news/how-much-omega-3-should-you-take-each-day/articleshow/67672802.cms
Top 8 Vegan Omega-3 Sources: How to Get Vegan Omega-3 Into the Diet
February 11, 2019 12:50 PM
Omega-3s have a wide variety of health benefits, from controlling inflammation to improving brain health. For vegans who wish to avoid fish-based omega-3 sources, a number of good vegan sources exist. Brussels sprouts are a superb source of omega-3s, as well as many other nutrients, as are walnuts. Algal oil — derived from algae — is another good source, and makes an excellent substitute for fish oil. Other good vegan sources include chia, flaxseed, hemp seed and spirulina.
"Fortunately, there are plenty of ways to get a good amount of all three forms of omega-3 fatty acids into a plant-based diet, including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and alpha-linolenic acid (ALA)."
Read more: https://draxe.com/vegan-omega-3/
Chia Seeds vs Flax Seeds: Which Is Healthier?
February 07, 2019 10:42 AM
Although chia and flax seeds both have distinct benefits that provide consumers with health advantages, each of these seedling varieties excel in different areas. For instance, if you are experiencing some constipation, the high amounts of fiber located within chia seeds may help relieve your discomfort. When it comes to other ailments such as Crohn's Disease, flax seeds may help due to their significant amount of selenium. Both chia seeds and flax seeds have over 4 grams of protein per serving, making them a go-to treat for body builders.
"Chia seeds and flax seeds nutrition both include a good amount of fiber and protein. They both also have an extensive nutrient profile and provide a type of omega-3 fatty acid called alpha-linolenic acid (ALA)."
Read more: https://draxe.com/chia-seeds-vs-flax-seeds-which-is-healthier/
10 Healthy reasons to add flax seed to your diet
May 03, 2017 12:29 PM
Flaxseed has been cultivated in the US since the earliest colonists used it to produce textiles. However, modern research has shown that the health benefits of adding flaxseed to your diet are significant and numerous. High nutrient content, including fiber, protein, and heart-healthy omega-3s, great control over blood sugar and satiety, and a good source of anti-cancer lignan compounds all make flaxseed an important part of a healthy diet. It isn't just a superfood: it also makes a great ingredient!
"Years of research have shown that flaxseed and its byproducts contain high levels of essential vitamins and minerals, making the crop a staple superfood in various diet schemes"
Read more: http://www.naturalnews.com/2017-04-28-10-healthy-reasons-to-add-flax-seed-to-your-diet.html
The Health Benefits of Flaxseed Oil.
March 14, 2014 11:00 PM
What is flaxseed
Flaxseed and also flaxseed oil incorporate alpha-linolenic chemical p (ALA), a precursor to the primary omega-3 oily acid that to a certain degree and inefficiently turns in to DHA and EPA -- extra active omega-3s -- methods. While flaxseed hasn't yet been proven to improve heart disease risk, there's very good evidence that flaxseed and also flaxseed oil may reduced cholesterol degrees.
Benefits of flaxseed
Flaxseed oil may also be helpful with menopausal signs. Research has proven in which 40 grams daily may be a lot like hormone treatment for improving mild menopause signs, such as sizzling whizzes and nights sweats. Ground flaxseed may also ease constipation.
Flaxseed has additionally been shown to improve kidney function in people with lupus. If you have lupus or any other medical condition it’s crucial to talk together with your doctor about almost any supplements you receive.
Flaxseed oil, including sea food oil, has been studied for reducing triglycerides. Nevertheless, it is vital to ingest much flaxseed oil (38-60 grams) to have any noticeable consequences.
Flaxseed is being studied for several other conditions, between cancers to diabetes to assist osteoporosis. At this factor, there is too few evidence to assistance flaxseed for most of these conditions
Flaxseed oil in addition has become found to get beneficial if you happen to suffer from Crohn’s Disease and Colitis. Several studies have found it oil seems to be able to calm the inner lining to the inflamed intestines. Another benefit exists even as have an excessive written content of mucilage in flax this too is an efficient natural laxative.
Flaxseed oil is beneficial in helping to relieve high cholesterol. It’s important to make note of however, that this alone can't be totally effective throughout conserving cholesterol degrees, an overhaul linked to overall diet should work jointly along with flaxseed oil.
The probability of heart illness will be leaner in people that take flaxseed petrol. Evidence indicates that those who eat lots associated using ALA are less in danger of suffer a critical heart attack and yes it reduces high leading to help tinnitus pressure.
Some men and women endure Sjogren’s syndrome, which is dryness with your sight. Flaxseed oil really helps to improve this concern.
Flaxseed Oil - A Essential Oil
November 06, 2012 12:16 PM
Flax seed oil
Flax seed oil is extracted from the flax seeds. According to the research, it is known that, flax seed contains enormous amount of Omega - 3 fatty acids which is considered to be very important for our health. It is also rich in fiber and other necessary proteins, Omega - 6 fatty acids, Vitamin B, copper, magnesium, zinc and potassium.
The following are the benefits of flax seed oil to our overall health which do not limit to the following:
Along with these benefits it is mainly used as a supplement to prevent cancer, particularly, breast cancer and colon cancer. Lignans in flax seed plays an important role to protect cancer. Antioxidant qualities present in lignans help reduce female related ailments, reduces menopause problems, and many more. Lignans also step in to reduce the growth of tumors.
As we know, flax seed oil is rich in Omega - 3 fatty acids, which is also known as alpha-linolenic acid (ALA), helps to fight cardiovascular ailments by lowering cholesterol levels. According to the research it is proved that with regular consumption of flax seed oil, lesser number of people suffer from heart attacks.
Flax seed oil naturally has numerous health benefits. Consumption of this healthy oil will add to our good health. Flax seed oil can be taken in the form of capsules or can be replaced with our daily cooking oil. Please consult a doctor before taking this supplement.
Alpha Lipoic Acid
December 11, 2008 11:19 AM
Alpha lipoic acid is the ideal antioxidant for five main reasons. It can scavenge free radicals of all kinds of both fat and water-based cell structures. It rapidly assimilates and absorbs into cells. Alpha lipoic acid boosts the action of other protective compounds. It chelates free meal ions and it also promotes normal cell replication.
Alpha lipoic acid (ALA) is both fat and water soluble, which makes it a superior free-radical scavenger because it can protect lipid (fat) and aqueous (water) cell parts from free-radical damage. This ability allows ALA to offer excellent cellular protection because it can easily transport across cell membranes and give oxidant protection outside and inside cell structures. ALA has the ability to freely move throughout all cell parts, scavenging for free radicals in a way that is definitely more effective than other antioxidant compounds. Vitamin C, for example, is a good antioxidant but is strictly water soluble and only affects the interior of cells. On the other hand, vitamin E is only fat soluble, meaning that it affects only the lipid portion of cell structures or the membrane, which leaves other areas unprotected.
Cellular glutathione, which is produced in the body and works to neutralize free radicals, is very difficult to artificially boost. Although oral glutathione supplements are available, they have to go through the GI route before they enter the blood stream, leaving little glutathione which actually survives this process. Because of this, cellular levels are not significantly increase by oral supplementation. ALA has been found to help regenerate glutathione by providing extra cellular protection.
If the body becomes deficient in ALA, other antioxidant compounds may not work well. ALA plays an important role in boosting the activity of protective compounds such as vitamin E. ALA dramatically extends the life and effectiveness of other vital compounds.
ALA has been used for decades to treat diabetic conditions and complications including diabetic neuropathy, with ALA actually having the ability to initiate a reverse in the condition in some cases. Additionally, ALA helps to boost glucose uptake and results in less insulin dependency in some cases. Among its other properties, ALA can protect brain tissue on a cellular level, as well as protect brain cells from certain hazardous chemicals.
Research has shown that ALA may even play a role in the treatment of neurological disorders such as Huntington’s disease. As we are all aware, LDL cholesterol has a huge role in the development of cardiovascular disease. LDL cholesterol, which is particularly susceptible to free-radical damage, can be protected by ALA from free radical damage itself. Along with the above properties, ALA has been shown to help in strokes, cancer, cataracts, HIV, liver regeneration, and detoxification.
ALA can be purchased in tablet and capsule form and works well when it is orally ingested so that it can be easily assimilated through the walls of the gastrointestinal tract. Taking between 40 to 50 mg of ALA is recommended for best results. The primary applications of alpha lipoic acid are aging, aids, alcoholism, atherosclerosis, bell’s palsy, cataracts, cancer, cirrhosis, diabetes, diabetic neuropathy, multiple sclerosis, liver disease, radiation sickness or exposure, Alzheimer’s disease, senile dementia, stroke, Huntington’s disease, Parkinson’s disease, and heavy-metal poisoning. Have you had your alpha lipoic acid today?
What is Alpha Lipoic Acid?
July 18, 2008 12:36 PM
You can be sure that a supplement has some remarkable therapeutic possibilities when it makes headlines on the five o’clock news. A recent experiment which showed the conditions of rats that had been fed a diet that was totally deficient in vitamin E tested alpha lipoic acid, which caused the rats to return to full health even though no vitamin E was replenished. The results of this test are profound, as giving these rats an alpha lipoic acid caused existing stores of vitamin E that the body was previously unable to use to be regenerated.
Alpha lipoic acid is a vitamin-like antioxidant that has been used in Europe for a long period of time. It has recently emerged as an extremely impressive therapeutic agent that scavenges free-radicals. Recent studies have suggested that it has the ability to stop some degenerative diseases, the oxidative process of aging, and restores the health of diseased organs. Additionally, it has the ability to make up deficits of vitamin E or C and could potentially be one of the best treatments that have emerged for diabetes. Alpha lipoic acid (ALA) is considered to be more potent than vitamins E and C, as well as coenzyme Q10. Unlike other antioxidants, ALA has properties that make it superior because it is able to replace certain nutritional supplements, while potentiating others, and inhibiting tissues from deterioration that is associated with diseases. This supplement is also both fat and water soluble, which allows it to protect lipid and aqueous cell structures.
Alpha lipoic acid is a compound that is synthesized in small amounts in the body, but can also be supplied from food or supplement sources. A vitamin-like substance, it contains sulfur and also plays a crucial role in energy reactions. It can be found in liver, yeast, spinach, organ meats, broccoli, red potatoes, and red meat. When it is orally ingested, alpha lipoic acid is not compromised in the GI tract or the liver.
Numerous studies have been conducted on ALA, all of which confirm its positive effect on metabolic processes, with recent clinical tests supporting its ability to enhance free-radical protection, slow the aging process, and guard against a variety of degenerative diseases. ALA was discovered in the 1930s, where it was originally classified as a vitamin, and later categorized as an essential coenzyme when scientists discovered that it was involved in the energy processes of cell mitochondria. It wasn’t until 1988 that scientists found that it also has powerful antioxidant effects.
Alpha lipoic acid is important because it protects us from free-radicals which are present in a body as a result of the number of toxic substances such as auto exhaust, tobacco smoke, pollution, preservatives, and additives that we are exposed to on a daily basis. These free radicals can actually accelerate the aging process, causing premature tissue breakdown to occur. Additionally, our environment will continue to surround us with these pollutants that create free radicals.
There are things we can do to minimize our health risks, which include exercising, eating nutritiously, and not smoking. However, these measures are rarely enough to decrease our risk for certain degenerative disease a substantial amount. ALA is beneficial because it scavenges oxidants that are left behind and helps to convert carbohydrates, fatty acids and protein to energy that is needed to drive muscle movements.
Are Inflammation, Immunity, And Allergic Reactions A Role For Supplements?
November 10, 2007 11:29 AM
Inflammation, immunity diseases and allergic reactions are all connected with your immune system, and the way the body reacts to what it considers to be foreign invaders that are a risk to your health. Although you may not understand that all three have the basic underlying cause, in fact they do, and here is why.
Inflammation manifests as pain and swelling in the inflamed area, and not only can the area also get hot, but it can also raise your temperature in general, commonly called a fever. Fever is the body’s way of raising temperature above that at which foreign organisms such as bacteria and viruses can live, so any inflammatory condition that results in fever by definition must be an immune response through the body trying to eliminate foreign invaders.
If your body gets injured in any way, your immune system responds, and usually calms down again if decides that the injury is not serious. Your immune system is actually initiated by what are known as pro-inflammatory hormones, such as prostaglandins that stimulate the nerves to signal pain and swell the blood vessels close to the injury to make room for the large white blood cells when they arrive. That also allows blood and plasma to rush out and cause swelling at the site of the injury. Other prostaglandins act to quell the immune response, and get your body back to normal.
Another such hormone is a cytokine, which informs the brain of the intrusion. Some cytokines called leukocytes stop the immune system when necessary to prevent the destruction of healthy tissue, and also halt the inflammatory response. If the leukocytes are not working properly, the body can be severely damaged as the immune system becomes uncontrolled and starts to attack healthy tissue.
Then there are the histamines that allow you to expel the agents causing the problem by sneezing, watery eyes, runny noses and scratching. They lead lymphatic fluid and blood to the site of the problem in order that the invasion can be attacked and destroyed.
It is the histamines that provide what is commonly referred to as an allergic reaction, which is really the immune system coming into action to remove invaders such as pollen, dust mites and any other agent that can cause an allergy. Immunity is caused by introducing small amounts of the agent into the blood, so that the immune system can develop a memory of them. Then, when the same invader returns at a later date, the system can immediately attack them with the antibodies that have been produced.
All of these: inflammation, immunity and allergies, are caused by the reaction of the immune system to what it perceives as an invader. Normally these are bacteria and viruses, but sometimes they react to other foreign bodies such as pollen. In some people this provokes no response at all, while in others it provokes the immune system to create antibodies against the pollen, and emit histamine to expel it.
Substances that cause allergies are referred to as allergens. Many allergens are environmental, such as dust, pollen and peanuts. Some people are allergic to certain animals, such as cats or dogs, and others to chemicals in the air such as hydrocarbon emissions, particularly when in particulate form.
The symptoms can be simple, such as a runny nose, a cough and hay fever or more complex such as hives, eczema and asthma. All of these are caused by the immune system reacting to an invader. There are also foods that cause internal inflammation, such as shellfish and whitefish, eggs and tomatoes. Many of these can be extreme, leading to serious illness and can even be fatal. So what can be done to treat people who are particularly prone to inflammation and allergic reactions?
Omega-3 fatty acids have been found to reduce inflammation, unlike their Omega-6 cousins that appear to increase it. Omega-3 oils contain chemicals known as eicosanoids, of which the prostaglandins are an example. While this might seem paradoxical, since prostaglandins are what set off the whole process, there are many types of these. Prostaglandin E2 is the type that leads to allergic immune reactions, and omega-3 fatty acids reduce the concentration of these in the blood.
Those who eat little fish tend to suffer more from inflammatory conditions such as arthritis and other conditions indicating a lack of control of the immune system. On the other hand, processed foods contain more omega-6 fatty acids that can promote these conditions. The major components of omega-3 oils are alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA) and also DHA, docosahexaenoic acid. These are all anti-inflammatories and have been shown to have very positive effects on inflammatory conditions such as rheumatoid arthritis, Crohn’s disease and eczema. Each of these is a different type of inflammatory condition caused by inappropriate immune response.
However, it not just fish oils that can help resolve problems with our immune system. Quercetin is what is known as a flavonoid. It is a strong anti-oxidant and natural anti-histamine that combats histamine release and the swelling associated with the immune response to allergens. It also counters the inflammatory agents of arthritis and so helps to reduce the pain associated with many of these conditions. It appears to work better in conjunction with bromelain, a very powerful anti-inflammatory that also possesses anti-allergen response properties. Bromelain is extracted from pineapple stems.
Another natural product is a resin extract that is obtained from the Boswellia serrata tree. It has powerful anti-inflammatory properties, and has been recommended for the treatment of arthritis (rheumatoid and osteo), Crohn’s disease and has been suggested as a treatment for asthma, though studies are still under way. However, world wide experience is that Boswellia is effective against gout, psoriasis and ulcerative colitis, to name another three totally different inflammatory conditions.
What all of this indicates are two things. First that inflammation, immunity and allergic reactions are connected conditions, and due to either poor control over or an over stimulated immune response to what the body perceives as being abnormal, in the way that hormones and other chemicals that are used to control our immunity detect it to be.
Secondly, there are many natural products that can be used as supplements to treat these effects caused by the immune system, and that their effectiveness has been proven, if not by scientific study, then by generations of traditional application as treatments of the symptoms of the conditions concerned.
However, although many have been proved by scientific study, others have not, and you should always refer to your physician before undergoing any treatment other than that prescribed. Also, there is incontrovertible evidence that the role for supplements in the treatment of inflammation, immunity and allergic reactions are beneficial. Many use nothing else.
Taming the Tingle – ALA helps fight nerve damage caused by diabetes…and more.
November 09, 2006 01:27 PM
For some people the constant tingling in their feet is the worst part. Others feel like their feet are being stabbed or burned, or that their extremities are simply lifeless. All these folks suffer from peripheral neuropathy, nerve damage that afflicts nearly 30% of people with diabetes aged 40 and older. And if the discomforting sensations are not enough, neuropathy can lead to falls, wounds that won’t heal, even amputation.
Untold numbers of individuals have been helped by alpha lipoic acid (ALA), a supplement that European practitioners have used as a standard neuropathy treatment for 30 years. ALA (also known as thioctic acid) assists in the chemical reaction that generates energy within cells. It serves as a universal antioxidant—a substance that can fight tissue-damaging free radicals in both the fatty watery parts of a cell-and helps the body create additional free radical fighters, such as glutathione. ALA can even help regenerate several other antioxidants, including coenzyme Q10 (CoQ10) and vitamins C and E.
People with diabetes need antioxidant protection as much as anyone. Fortunately for them, though, ALA fights this insidious disorder in many other ways.
Diabetes occurs when the body can no longer effectively use glucose (blood sugar), its main energy sources; ALA helps shepherd glucose out of the blood and into cells. It also interferes with glycosylation, a process in which glucose sticks to proteins such as the low-density lipoprotein (LDL) that carries cholesterol through the bloodstream. That’s important because this “sticky” LDL can adhere to arterial walls, creating a major risk factor for heart disease. ALA combined with exercise appears to make insulin, the hormone that controls glucose usage, more effective. What’s more, early research indicates that ALA can deflect another cardio hazard by interfering with the ability of salt to push blood pressure upward (molecular and Cellular Biology 12/03).
ALA Annotations – what is it? Alpha Lipoic acid, a substance the body creates naturally.
What it Does: ALA, a powerful antioxidant in its own right, plays a vital role in the creation and renewal of other antioxidants. It is used to treat peripheral neuropathy; nerve damage caused by diabetes, and is also under investigation for possible therapeutic effects in other disorders, including multiple sclerosis and age-related cognitive decline.
Diabetes doesn’t just attack the nerves and the heart—its effects are felt throughout the body. That’s why scientists are examining whether ALA can tackle other diabetic complications: in lab studies it has forestalled diabetes-related kidney and eye damage. (Check blood-sugar levels regularly when using ALA, especially if you’re taking other glucose regulators.)
While diabetes is one of the most common causes of nervous system damage, it isn’t the only one. In test tube studies ALA has promoted chemical reactions that encourage neurons (nerve cells) to survive and grow; as a result some scientists believe this natural antioxidant may eventually play a role in treating degenerative nerve disorders. Such research is in its beginning stages, but the results are still intriguing. For example, in mice ALA has slowed progression of a disorder that mimics multiple sclerosis in human beings (Journal of Neuroimmunology 3/04) and improved age-related memory loss when used with N-acetyl-cysteine (NAC), another antioxidant supplement (Journal of Neurochemistry 3/03). A number of other conditions that become more common with age may also benefit from ALA, including arthritis and thinning skin.
If you suffer from both diabetes and the nerve damage it causes, ask your practitioner about ALA. It just may help your feet and the rest of you feel happy. –Lisa James
Effer-C NUTRITION YOU CAN DRINK
December 27, 2005 09:49 AM
Essential Fatty Acids - Lipids, Cell Memgranes & Eicosanoids
June 09, 2005 09:35 AM
Essential Fatty Acids and Phospholipids
Essential fatty acids & phospholipids are primary constituents of cell membranes, and as such they are vital to the makeup of the human body. Essential fatty acids are used to generate certain intra-cellular hormone-like substances, including prostaglandins and leukotrienes, which are responsible for regulating key bodily processes. Source Naturals essential fatty acid supplements are potent, effective and chemical-free.
LIPIDS, CELL MEMBRANES & EICOSANOIDS
Almost by definition, life is composed of cells, and cells are defined by membranes. One theory suggests that, around four billion years ago, self-replicating molecules, similar to the ribonucleic acid or RNA in our own cells, were synthesized from organic molecules. These self-replicating molecules adapted to changes in their environment to increase their potential for survival. Thus began the process of evolution that has led, over the eons, to us. One turning point was when these molecules developed membranes - envelopes which could help concentrate chemicals needed for the cell's survival. There existed in the "primordial soup" substances uniquely suited to this purpose: a class of organic compounds we call lipids . Lipids are more commonly called fats, and in this health and image-conscious age people often think of them as something to be avoided. However, the word fat refers to a variety of substances with a diverse range of chemical properties, which are essential for survival and well-being . The simplest lipids, fatty acids such as palmitic acid, consist of a hydrocarbon "tail" connected to a carboxyl group (COOH). The majority of lipids in food and in the human body occur in the form of triglycerides - a molecular configuration in which three fatty acid chains are attached to a 'backbone' of glycerol (an organic alcohol composed of a 3-carbon chain with an alcohol group attached to each carbon). The major roles of lipids can be described as energy and storage, structural, and metabolic.
Energy and Storage
Molecules can contain more or less chemical energy. In living systems most of the energy needed to drive chemical reactions is derived from oxidation. Oxygen, the ultimate electron acceptor, is a strong oxidant: it has a marked tendency to attract electrons, becoming reduced in the process. When a molecule undergoes a chemical reaction from a high-energy reduced state to a low-energy oxidized state, energy is released. This is what happens in a fire: the high-energy carbohydrates in wood, such as glucose, react with oxygen, releasing heat and the low-energy molecules of carbon dioxide and water. This is similar to what happens in metabolism.
Most of the carbon in a fatty acid chain is highly reduced, which makes fats more energy-rich than the other organic molecules that can be burned as food. This is what we mean when we say fats are high in calories - a measure of the amount of energy released when a substance is oxidized. Fats contain more than twice as many calories as carbohydrates. This makes fats an important storage fuel for most of the body.
Another important class of lipids in the human body consists of the phospholipids. Like triglycerides, phospholipids contain fatty acid chains- in this case two, one saturated and one unsaturated, attached to a glycerol backbone. Unlike triglycerides, in phospholipids the third carbon of the glycerol molecule is attached to a phosphate (a molecular group that contains phosphorus and oxygen), which is in turn attached to either an amino acid or, in the case of phosphatidyl choline, a molecule of the B-vitamin - like substance, choline.
Their unique molecular structure makes phospholipids amphipathic, which means 'likes both':
Fats, being hydrophobic, tend to separate out from water. When fat is mixed with phospholipids in the presence of water, the phospholipid molecules attach themselves to the molecules of fat and bring them into the water solution, enabling the fats to dissolve in water.
Phospholipids form a structure called a lipid bilayer, a two-ply sheet of phospholipid molecules in which the hydrophilic head groups face outward and are in contact with the water, and the hydrophobic tails face each other on the inside of the bilayer. This structure is one of the key constituents of the cell membranes that surround every living cell.
The lipid bilayer of cell membranes is a fluid in which membrane-embedded proteins "float." These proteins serve a wide variety of different functions. Some are enzymes, serving to carry out chemical reactions in the adjacent solution. Some are involved in signaling, in which a biochemical action in a cell is 'commanded' by means of a hormone or some such other signaling molecule. Still others are involved in transporting substances across the membrane, into or out of the cell.
The functions of membrane-embedded proteins are dependent on a very precise bALAnce of phospholipids for their function. Phosphatidyl serine, for instance, has a negatively-charged head group that associates preferentially with a class of membrane-bound proteins called ATPases. ATPases regulate, among other things, the bALAnce of sodium and potassium in intra- and extracellular fluids, a bALAnce that is necessary for the integrity of our cells and also for the electrochemical impulses that make up our thoughts and feelings. Without phosphatidyl serine, these vitally important membrane-embedded proteins could not function.
Cholesterol is a waxy substance that is essential to the structure of cell membranes, which depend for their function on a delicate bALAnce between fluidity and solidity. Cholesterol provides a semifluid matrix, as well as enhancing membrane fluidity. About 80% of the cholesterol the body uses is manufactured by the liver; the other 20% is consumed in food. Elevated blood cholesterol levels are associated with heart disease. Saturated fats are converted into cholesterol more readily than unsaturated fats, and polyunsaturated fats usually depress blood cholesterol concentration to some degree. Researchers have thus recommended that people lower their consumption of saturated fats and increase their consumption of polyunsaturated fats. A process called hydrogenation , in which hydrogen molecules are added, is used to harden these unsaturated fats to create solid spreads, such as margarine. This process causes formation of altered fats called trans fatty acids. Although the results are not conclusive, human and animal studies have pointed to possible deleterious effects from consumption of trans - fatty acids, which are estimated to account for 5.5% of all fats consumed by Americans. These studies include one in men and women that showed harmful effects of trans - fatty acids on blood cholesterol ratios.
When each link of a fatty acid chain contains an atom of hydrogen, as in palmitic acid, that fatty acid is said to be saturated . If two carbon links are double bonded to each other, each has one less hydrogen atom, and the fatty acid chain is said to be unsaturated. If a fatty acid contains one double bond, it is said to be monounsaturated, and if it has two or more double bonds it is said to be polyunsaturated . Certain polyunsaturated fatty acids cannot be manufactured by the body and must be obtained from the diet. These nutrients are called essential fatty acids and are necessary for the normal function of all tissues. The essential fatty acids fall into two categories:
In addition to being phospholipid precursors, essential fatty acids can be converted to a class of hormone like intracellular messengers called eicosanoids. The physiologic effects of eicosanoids are potent in minute quantities. Their effects are so powerful that they need to be produced near the site of their action and are quickly inactivated. The important eicosanoids include the thromboxanes, leukotrienes and prostaglandins (PGs ). Prostaglandin molecules consist of a five-carbon ring with two side chains. They can be distinguished from each other by numbers that refer to the number of double bonds in their molecular side chains: 1-series PGs have one double bond, 2-series have two double bonds, and so on. Prostaglandins mediate a variety of bodily processes, including inflammatory reactions, blood vessel contraction and dilation, and platelet aggregation. The different PGs have different effects on the body, and different essential fatty acids act as precursors for different PGs.
Important essential fatty acids in humans are the omega-6 fatty acids, which include linoleic acid (LA), gamma-linolenic acid (GLA), and arachidonic acid (AA). 1-series PGs are derived from GLA and tend to cause blood vessels to dilate and reduce the stickiness of platelets (cell fragments in the blood that help initiate blood clotting). 2-series PGs are derived from arachidonic acid and tend to increase platelet stickiness and cause blood vessels to constrict. Meat and dairy products are dietary sources of the PG2 precursor, arachidonic acid; American diets tend to be rich in these foods. The rate-limiting step for production of GLA in the human body is an enzyme called delta-6-desaturase (D6D). The action of this important enzyme can be blocked by a number of different lifestyle factors, including a diet high in saturated or trans- fatty acids and chronic alcohol consumption. A modest increase in consumption of GLA will significantly increase the ratio of GLA to AA in the tissues, which may have a beneficial effect on the homeostasis of the cardiovascular system. Supplementation with omega-3 fatty acids, such as flaxseed oil or fish oil, is beneficial for similar reasons. Omega-3 fatty acids are precursors for 3-series PGs, which reduce platelet stickiness. Series-3 PGs also tend to inhibit conversion of AA into its metabolites, the 2-series PGs.
The lipid composition of our diets has changed radically in the 20th century. Our intake of saturated fats has increased dramatically, and trans fatty acids, which did not exist before the advent of modern food processing technology, now form a major part of our diets. We eat less fish and green leafy vegetables, important sources of omega-3 fatty acids, than our ancestors did. Far from being an inert, homogeneous substance, fat is dynamic and varied - a subtle and interactive matrix for many of the biological processes taking place in our bodies, minute by minute.
R-Lipoic Acid - Fulfilling the Potential of Lipoic Acid
June 04, 2005 02:23 PM
Lipoic acid may be the body’s most versatile nutrient. Its critical importance for health is scientifically documented. Not only is it a powerful antioxidant, it supports healthy sugar metabolism and liver function, and is integral to energy generation, which affects all biological functions. But few know that the commonly available form, alpha lipoic acid (ALA), is not the same compound that occurs naturally in our bodies. ALA is a 50/50 combination of natural form r-lipoic and synthetic s-lipoic acid—and the synthetic form may actually block the activity of r-lipoic acid, resulting in a weaker product. Because it is the natural form, r-lipoic acid is better absorbed and safely metabolized. And it is up to 10 times more effective at producing cellular energy, according to in vitro research, and may be a more potent antioxidant. Source Naturals, the science company, is proud to be one of the first to offer this breakthrough nutrient: R-LIPOIC ACID
R-Lipoic Acid: Key to Cellular Energy Generation
Plants capture solar energy in their carbohydrates. In a reverse process called oxidation, animals extract that energy. R-LIPOIC ACID is a vital link in the metabolic pathway that gives us the power to move and the energy of intelligence. R-LIPOIC ACID is synthesized in the mitochondria, the tiny power plants inside every cell that produce energy in the form of ATP. It is safely metabolized and up to 10 times more effective than other forms of lipoic acid in mitochondrial ATP production, according to an in vitro study.
Supports Glucose Metabolism
Human and animal studies show that R-LIPOIC ACID can increase glucose uptake by muscle and nerve cells. By enhancing sugar metabolism, R-LIPOIC ACID may protect cells from glycation. In this detrimental process, excess glucose reacts with proteins to create tough crosslinked bonds that damage vital proteins, including the myelin sheath of neurons and the lens of the eye. Scientists believe glycation is a major source of tissue degradation and cellular aging. Collagen, another important protein, is also subject to crosslinking, which inhibits the flexibility of blood vessel walls—one of the most important indicators of cardiovascular health.
Increases Antioxidant Protection
R-LIPOIC ACID also neutralizes the harmful byproducts of glucose metabolism, free radicals. The body synthesizes barely enough R-LIPOIC ACID for its metabolic needs, and this decreases with age. As mitochondrial energy production becomes less efficient, more free radicals are generated. R-LIPOIC ACID protects cells, particularly in the mitochondria, where most oxygen damage occurs. R-LIPOIC ACID is a leading component of the body’s antioxidant network. Unlike other antioxidants, it is water and fat-soluble, so it neutralizes a greater number and broader range of free radicals, providing more protection. In animal studies, R-LIPOIC ACID slowed the aging process, which may be the result of cumulative oxidative damage. Lipoic acid, known as the “universal antioxidant,” is a strong antioxidant in its own right, but it also directly recycles vitamin C and indirectly recycles vitamin E for continued use. And R-LIPOIC ACID is more efficient than other forms of lipoic acid at increasing levels of the key antioxidants, CoQ10 and glutathione. Commercial alpha-lipoic acid is 50% synthetic s-lipoic acid, which can interfere with natural form R-LIPOIC ACID when both forms compete for binding sites. Tests showed 40% better absorption by R-LIPOIC ACID, as measured by plasma concentration levels.
Integral to Your Wellness Program
Because it is central to such critical functions as energy generation, antioxidant protection, anti-glycation activity, and liver support, R-LIPOIC ACID belongs at the center of your wellness program. Source Naturals is happy to join forces with your natural foods retailer in bringing you this advanced nutrient.
Arcticpure EFA and EPA Fish Oil supplement ...
May 31, 2005 05:05 PM
Essential fatty acids are crucial for health—as much so as daily vitamins and minerals. And fish oil is one of the best sources of these nutrients. Now Source Naturals offers you three premium fish oil concentrates. ARCTICPURE DHA supplies the essential brain nutrient DHA. ARCTICPURE EPA is ideal for cardiovascular support and joint mobility. ARCTICPURE EFA contains a blend of healthful fatty acids. All ARCTICPURE products contain fish oils from the cleanest and coldest body of water, the Arctic Sea. A series of distillation processes concentrates and extracts beneficial fatty acids, while guaranteeing the absence of heavy metals and PCB’s.
EFA’s: Healthy Fats
Essential fatty acids (EFA’s) support an amazing variety of cellular processes. They maintain cell wall and membrane integrity, generate energy, produce hormones and support brain, nerve, and eye function. Yet too many people today eat diets that are high in saturated or hydrogenated fats, but low in healthy fats—essential fatty acids. ARCTICPURE softgels are an excellent source of EFA’s, including docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), gamma linolenic acid (GLA), and alpha linolenic acid (ALA). ArcticPure DHA™ DHA is an omega-3 long chain fatty acid that is the primary building block of the brain and retina of the eye. The brain is 60% fat, and DHA is the most abundant fatty acid in the brain, comprising 25-35%. DHA is found in even greater concentrations—50-60%—in the retina. DHA is critical for infant development, especially the rapid cerebral and eye development that occurs during pregnancy and in the first few months after birth. It is therefore an important nutrient for pregnant women and nursing mothers. DHA also has been associated with optimal memory function, visual acuity, and maintaining a positive mental state. It is an integral component of all membranes with electrical activity, including the cells in our brain and nervous system. ARCTICPURE DHA contains 50% DHA, or 250 mg, in each softgel.
EPA is another omega-3 fatty acid, which has been associated with many potential health benefits. Epidemiological and animal studies have shown that EPA can support a healthy cardiovascular system. It is important for healthy skin and is a precursor of prostaglandins, thromboxanes and leukotrienes. These chemical mediators help regulate a variety of physiological processes, including blood pressure and blood clotting. ARCTICPURE EPA supplies 45% (450 mg) of EPA—one of the highest concentrations available.
ARCTICPURE EFA is a source of EPA, DHA, and also GLA (gamma-linolenic acid) from borage oil, and additional omega-3 fatty acids including ALA. GLA is an essential polyunsaturated fatty acid. It is used by most cells to produce the soothing, intracellular, hormonelike messengers known as series 1 prostaglandins (PGE1), which help maintain the bALAnce of many functions in the body. GLA supports the immune system and helps maintain healthy skin and circulation. This essential nutrient is incorporated into our cell membranes, where it helps to maintain fluidity and permeability.
Stabilized for Freshness
ARCTICPURE oils are enhanced with antioxidants such as lecithin, ascorbyl palmitate, vitamin E and rosemary oil, for extended shelf life. They also contain natural fruit flavors, so there is no fishy taste! ARCTICPURE softgels are pleasing to both children and adults.
Lignan Extract and Cardiovascular health ...
May 26, 2005 09:38 AM
Lignan Extract 70mg (30sg,60sg)
2 Capsules Contain:
Suggested use: 2 caspules daily with or without meals, or as recommended by your health care professional.
Lignan Extract Supports Cardiovascular healthMaintaining healthy cholesterol levels is of critical importance to your customers. And with so many environmental and lifestyle factors standing in their way, they need an ally in their struggle to stay well. That's why source naturals has developed a highly concentrated Lignan extract.
Lignans are a type of phytoestrogen that clinical research has shown supports the cardiovascular system by reducing lipid peroxidation and maintaining cholesterol levels already in the normal range. It also promotes cell health by regulating hormone metabolism and acting as an antioxidant.
Though lignans is found in a variety of natural sources, flax is an abundantly rich source, providing up to 800 times more of this beneficial nutrient than any other plant. Because it's made from the flax seed hull rather then its oil, Source Naturals Lignan Extract contains up to 30 times more lignan than typical flax extracts.
Our highly potent Lignan Extract offers powerful support for your customers' good health.