Search Term: " 20th "
Study: PQQ (pyrroloquinoline quinone) may prevent and even reverseAlzheimer's
January 04, 2019 08:12 AM
Pyrroloquinoline quinone (PPQ) is a microbe that is derived from plants, and it is showing to have neurological benefits that are associated with the prevention of Alzheimer's progression. This particular microbe is able to reduce inflammation in the brain, which can lead to several neurological conditions. It also helps patients in post-stroke recovery because it is able to reduce the area of the brain that is impacted by stroke activity. Most importantly, it helps in the prevention of Alzheimer's due to how it can neutralize levels of oxidative stress.
"Glutamate is an important chemical in the brain, but too much of it results in excitotoxicity, a risk factor in both stroke and neurodegenerative disease. PQQ protects the brain from overstimulation by glutamate and the resulting death of brain cells."
Read more: https://www.naturalnews.com/2018-12-15-ppq-can-prevent-alzheimers.html
12 Reasons To Use Digestive Bitters For Better Digestion And More
August 03, 2018 09:53 AM
Digestive bitters have been around since the 16th century, and they made a huge comeback in the mid-20th century. Ingesting digestive bitters after you've had a meal can help line your stomach and prepare it for the contractions that go along with healthy digestion. It is also known to help ease problematic symptoms such as gas and bloating that can go along with food intolerance issues or just the digestion process of certain foods in general.
"Together, these comprise four of our five taste senses, but the fifth flavor is virtually absent from our modern day diets."
Read more: https://www.thealternativedaily.com/12-reasons-to-use-digestive-bitters-for-better-digestion-and-more/
How 4/20 became 'Weed Day'
April 22, 2017 10:44 AM
Smoke one, toke one! April 20th is the annual day for weed smokers to unite, just like Easter or Christmas for other people, by tradition. If you are a toker wondering how 420 became the national weed day, this is the information that you want to read. You can learn all about the history of 420 so the next time you take a toke, you will do so with this important information in your mind.
Read more: How 4/20 became 'Weed Day'
Traditional Uses of Blessed Thistle
CHANGING YOUR LIFE WITH MAGNESIUM
October 31, 2014 06:05 AM
Do you want to get some information about Magnesium?
Magnesium has been found to be working in other ways to contribute in preserving the nervous system. Before the end of 20th Century, specialized doctors had established that injection of magnesium in our bodies exerts a depressant effect on the nerves. In fact, the main use of this mineral in early times was to induce sleep. Significantly, any hibernating animal have high levels of magnesium. The mineral has also shown effectiveness in control of convulsion in pregnant women, the shakes in alcoholic and epileptic seizure.
MAGNESIUM CALMING THE NERVOUS SYSTEM
One of paradoxical effect is that, a magnesium deficient person who end up taking magnesium will feel energetic than never before yet the mineral is not a stimulant but rather a depressant. Actually, magnesium normally relieves the irritability of nervous system and the excessive energy, which will result to fatigue.
With this, it will not be surprising to say that when an individual magnesium levels is sub-normal then the nerves will not be in a position of controlling functions such as muscle movement, mental processes and respiration. Irregular heartbeat, twitching, irritability and largely nervous fatigue are the most frequent symptoms of magnesium depletion.
Often, deficiency of magnesium is because of failure on individual side to obtain to use dietary sources such as eggs, wheat germ, green vegetables, cocoa, almonds, soybeans, desiccated liver among many other. However, in some instances, coexisting illness can impair absorption of this mineral, for example the intestinal infections. In such an instant, ingested magnesium may be lost completely in the body and majorly in the nervous system.
PENN of Columbia University published the information of essential of magnesium to nervous system first in 1966. He studied the conduction of electricity by the nerves. The main finding was that calcium is the prime conductor mineral of the electrical current. It was concluded from the finding that Magnesium would in turn maintain the required level of calcium in the nervous system. Actually, Magnesium is Do you want to get some information about Magnesium? The nutrient that is likely to change your living standards by improving your nerve health.
1. THE MAGNESIUM ONLINE LIBRARY.
2. // WWW.MGWATER.COM/
Supplements That Can Improve Focus
March 23, 2014 07:57 AM
A focused mind is one that is able to concentrate on a particular issue and think about it, discuss it or deal with it and pay special attention to that subject. This explains why people have different focus abilities as brought about by their varying environments and capabilities. Enhanced minds quickly grasp ideas as opposed to low minded ones. A determined mind therefore understands and interpret facts more readily in an effective way, and this is why it is important for individuals to to be focused at school. However, there are instances where learners have limited focus abilities, but this can be improved by use of focus supplements. The following are the supplements that can be used to boost an individual's focus levels.
Supplement that can help improve focus
Does Acidophilus Interfere With Antibiotics?
October 19, 2011 03:43 PM
As a term, acidophilus is used for describing various bacteria which aids in the process of human digestion. These different types of bacteria namely are: L. acidophilus, L Casei, L Bulgaricus just to name a few. Lactobacilus acidophilus is a single part of these mixtures however when it is mixed with other good bacteria it is commonly referred to as acidophilus. These good bacteria also known as a probiotics (bacteria that is used for beneficial purposes for the human health) has been touted to have many health benefits. In fact some of these health benefits have been known for thousands of years. Acidophilus is naturally found all throughout the body and is most likely made its way into our food hundreds if not thousands of years ago. It has the ability to ferment in which eventually humans figured they could and should artificially duplicate and alas we did. One of the main functions of acidophilus is to eat up sugar when placed in a rich sugar environment and they convert it to various substances like lactic acid. This is how it is able to preserve food. It is able to lower down the pH of the food it is used in so that the flora is not as friendly to other bacteria. Yogurt is the most well-known example of food that uses acidophilus and that is where it gets that sour taste.
Antibiotics simply mean if literally translated from its greek origins "against bacteria life forms" which is why it is commonly considered as an anti-bacterial substance. They are basically drugs that are used for the treatment for different types of infections which are caused by bacteria, the type of bacteria that are pathogens and not the probiotic ones. When our immune system fails in attacking and killing the bacteria that is attacking our body which does not happen often, we in turn will get ill and this is when we will need the help of antibiotics because that is its main function. The first ever antibiotic was penicillin, it was so amazing for a lot people that it was called the wonder drug when it first came in the mid 20th century. It was able to give hope to people that have infections that previously where life threatening but with the existence of penicillin they were alleviated of the symptoms in just a few days.
Acidophilus and Antibiotics
By now after reading what is above you will be able to conclude that Acidophilus can’t interfere with the work of Antibiotics. That is true because if anything the antibiotic will destroy the acidophilus because that is what an antibiotic does. It kills bacteria and unfortunately is not able to determine which are good and which are bad bacteria? So it will kill all bacteria that it comes into contact with. The recommendation is actually the other way around, avoid probiotic supplementation when you are taking antibiotics as well or if not make sure it is as far apart as possible to when you take antibiotics during the course of the day.
This is why it is important to take acidophilus while on antibiotics. Never take both at the same time. Allow 4 – 6 hours between application of antibiotics when taking acidophilus.
If you are on antibiotics, then grab yourself some probiotic acidophilus today!
How Does Grapefruit Seed Extract Help Fight Candida Yeast Infections?
August 08, 2011 06:51 PM
Grapefruit seed extract is processed from the seeds, pulp, and vesicles of the sour citrus fruit known as grapefruit. Nutrition experts have attributed several medicinal properties to the plant. In addition, practitioners of herbal medicine make use of the seeds and membranes of the fruit in health tonics. It has long been linked to the treatment of earache, sore throat, digestive problems, and yeast infections.
Citrus x paradisi is a hybrid species of pomelo and orange. Its fruits are much larger than oranges but smaller than pomelos, growing up to 15 centimeters in diameter on average. It is widely known as a naturally occurring hybrid, like sweet orange. The juice of popular varieties of the fruit comes in colors red and pink in respect to its ripeness. Some cultivars are sweet, but most are sour at the same time.
Many organic compounds isolated from grapefruit have long been observed to show pharmacological activity. For one, consumptions of the fruit itself have been reported to interact with numerous drugs. It either enhances the potency of drugs or inhibits their pharmacological activities. Researchers have enumerated a long list of drugs whose bioavailability increase in the presence of grapefruit extracts.
Proponents of grapefruit seed extract believe that it possesses antibacterial, antiviral, and antifungal properties. They began promoting its medicinal uses at the turn of the 20th century. At that time, physicians took note of the many benefits tied to grapefruit in the earlier century. Furthermore, they produced the first extracts from the seeds and white membranes of the fruit mixed with glycerin.
Grapefruit seed extract is an all natural remedy for Candidiasis. As its name suggests, Candida yeast infections are caused by different species of fungi that belong to the genus Candida. These fungi are part of the normal flora of the human body that comprises bacteria and other microorganism. While they are not harmful in general, they are capable of producing harm and spurring inflammation.
Oral thrush is one form of Candidiasis that infects mucus membranes located in the mouth cavity. Populations of yeast build up in the surface of the mouth and bring on inflammatory responses. The infection often appears as cream-colored deposits or slightly raised red patches. Candidiasis of the skin, sex organs, and other parts of the body look similar as they are all inflammatory in nature.
The effectiveness of grapefruit seed extract in the treatment of Candidiasis yeast infections has been compared to conventional medications. Its use is supported by anecdotal evidence that is largely positive. While the results of studies are conflicting at best, researchers have compared the extract to benzethonium chloride, a chemical compound that displays strong antibacterial and antifungal activity.
Grapefruit seed extract is a viable remedy for Candidiasis yeast infections. In fact, it may be used as a therapeutic prophylactic for infections caused not only by fungi but also viruses and bacteria. Due to its putative effect, it is added as an active ingredient to many personal care products.
How Does Lithium Help with Memory and Mental Disorders?
July 04, 2011 08:42 AM
Lithium And The Brain
Lithium is a chemical element whose ions have been observed to display pharmacological effects. It is best known as a treatment for mania and remains to this day an approved drug for mood disorders in several countries, including the US. It has been associated with countless scientific studies since the latter half of the 19th century. It is one of the most extensively studied of all drugs that alter mood.
Depression is an ancient disease of the mind that was referred to as melancholia in the ancient world. It has been noted in religious writings over the centuries. High energy levels and mental hyperactivity characteristic of bipolar disorder were once associated with supernatural causes. Religious beliefs have historically considered mental disorders as the work of the devil, and melancholia is not an exception.
Melancholia and mania were two separate mental conditions. The former was always tied to evil forces whereas the latter were thought to be triggered by other supernatural causes. Early Greek and Roman physicians noted that active behavior deemed to be pathological could be cured by drinking spring waters. Research have studied and reported that these spring waters actually contained lithium salts.
Manic depression was first posited in the 1950s to be a mental illness distinct from both melancholia and mania. It was in France when two psychiatrists independently observed the type of insanity that oscillates from between bouts of depression and mania. It was later categorized as a specific type of psychosis in that the condition was acute, and thus the patient functions normally after recovery.
Lithium was introduced as a treatment for manic depressive disorder in the form of lithium carbonate in the first half of the 20th century. Its use was discovered when lithium urate produced tranquilizing effects on animal subjects. Lithium salts were used as tranquilizers shortly after. Human experiments have proven to be effective in controlling patients chronically suffering from bouts of manic disorders.
Bipolar disorder is now the widely used term in psychiatry, though manic depression is still preferred by many medical professionals. It was first used in the 1950s to describe oscillations between two polar behaviors: mania and depression. It is a subtype of depression, the other one being major depression or unipolar depression. Lithium remains a drug for mania amid its changing descriptions.
Medicinal concentrations of lithium are generally considered safe in that they produce no apparent psychoactive effects. Instead, they work as a therapeutic treatment. It has been widely established that lithium possesses properties that stabilize mood, though its mechanism of action is still a matter of controversy. It is believed that lithium rebalances brain chemicals and alters gene expression.
Lithium appears to have an impact on several neurotransmitters present in the central nervous system, such as glutamate and serotonin Inasmuch as these neurotransmitters are noted for their role in mood and memory, some sources have ascribed nootropic effects to regular intake of lithium supplements.
Lithium is a wonderful supplement available over the counter. Try some Lithium today and feel the difference!
Does Boron Really Help Improve Bone Health?
July 01, 2011 11:06 AM
Boron and Bone Health
Boron is now widely considered an essential mineral, though its daily value is still a matter of debate. The physiological roles of this chemical element in the human body were unknown in the first half of the 20th century, but in recent years scientific research has proven that it is necessary for the calcium metabolism and vitamin D utilization, both of which significantly contribute to overall bone health.
There has not been any figure set in the dietary reference intake for boron largely owing to the fact that its nutritional importance has not been discovered until recently. As a result, important data on the safety of boron intake as a dietary mineral remains under investigation. Nonetheless, the scientific community is convinced that the presence of boron is required for many different metabolic processes.
Plants need relatively higher amounts of boron to survive. It follows that plant-based foods are very good sources of dietary boron whereas animal products have negligible amounts of this element. This chemical element was first noted to have a positive effect on joint health. The studies that followed have been observed that boron supplements alleviate symptoms of osteoarthritis in human trials.
Promotes Bone Health
Concentrations of boron in the synovial fluid and joint cartilage help determine the health of joints and bones. It has been reported that people who have higher amounts of elemental boron rarely develops degenerative joints diseases like osteoarthritis and symptoms of joint pain. Also, epidemiologic studies have shown that populations noted for healthy consumptions of boron have lower incidence of arthritis.
More recent studies have shown that boron intake is directly proportional to bone density. For one, it has been documented that supplementation of boron has an impact on bone strength in patients with osteoporosis. Clinical trials have produced very promising results as far as the treatment of bone loss is concerned. There is very good scientific evidence that boron supplements are superior to placebo.
Inhibits Bone Resorption
The skeletal system is the primary depot for minerals in the human body. Chemical elements obtained from the diet are stored in the bones or otherwise utilized by tissues and organs. In particular, more than half of the overall body concentrations of calcium, potassium, and magnesium are found in the bones, which are constantly remodeled to draw minerals out in response to the needs of body tissues.
The process of bone resorption is responsible for releasing the minerals from the bones into the blood. On the other hand, the process of bone resorption takes care of building bone tissue. If consumptions of dietary minerals are insufficient, resorption exceeds formation, as is the case with osteoporosis. The presence of boron promotes mineral retention in the bones, thereby increasing bone mass and density.
If you are experiencing osteoporosis, give boron a try!
Boost Energy, Improve circulation Heart Disease, And More with Methycobalamin (B12)
June 16, 2011 11:45 AM
Methylcobalamin is an organic compound that displays vitamin B12 activities inside the human body. It is one of the active forms of vitamin B12, and as such believed to be the most bioavailable of all vitamin B12 supplements. In fact, all other forms of vitamin B-12 in the market are converted into methylcobalamin when ingested. Its high absorption rate enables it to produce visible health benefits.
Influences Energy Production
Vitamin B12 is an indispensable component of many cellular activities. It is quite pervasive at the cellular level, inasmuch as it is directly involved in chemical reactions that lead to the production of adenosine triphosphate(ATP), the primary source of energy that fuels all metabolic processes within cells.
In particular, methylcobalamin participates in DNA synthesis, allowing each cell to effectively perform its physiological roles. Healthy levels of methylcobalamin protect the cells from DNA damage, and contribute to the rate of metabolism. Vitamin B12 deficiency seriously affects energy production.
Promotes Circulatory Health
Studies on anemia led to the discovery of vitamin B12. The causes for anemia were uncovered at the turn of the 20th century. High consumptions of liver appeared to cure anemia as liver are high in the dietary mineral iron. It was also later identified that vitamin B12 also cure one specific case of anemia.
Pernicious anemia is one of the many types of megaloblastic anemia, in which red blood cells appear large but immature. This results from a deficiency in vitamin B12. Methylcobalamin supplements have shown the best recovery rate for this type of anemia, promoting circulatory health in the process. The presence of methylcobalamin in the blood powers DNA synthesis and nourishes red blood cells.
Prevents Heart Disease
Methylcobalamin is particularly good for the heart and the blood vessels. Its presence in the bloodstream influences the levels of organic compounds, such as homocysteine, which are implicated in the death of myocardial cells and the formation of risk factors of cardiovascular diseases. The same endogenous compounds are incriminated in life-threatening conditions such as heart attacks.
Elevated levels of homocysteine in the blood raise the levels of asymmetric dimethylarginine, or ADMA, which directly cause cardiovascular disease. Regular intake of methylcobalamin has been observed to lower serum levels of homocysteine, which in turn lower ADMA concentrations in the bloodstream.
Improves Neuropathic Disorders
Neuropathy refers to damage to nerve cells to the extent of producing symptoms, such as muscle weakness, impaired reflexes, gait abnormalities, muscle twitch, tingling sensation, difficulty swallowing, speech impairment, urinary incontinence, and erectile dysfunction, among others.
Vitamin B12 is one of the many causes of peripheral neuropathy. Not surprisingly, supplementation of methylcobalamin significantly improves symptoms in very little time. Methylcobalamin has also shown encouraging results as an adjunct treatment for diabetic neuropathy. As a result, it also corrects the symptoms tied to neuropathic disorders, notably reflex impairment and muscle weakness.
Pick Up some Methylcobalamin (b-12) today and feel the difference!
What is Red Marine Algae And What Are Its Health Benefits?
June 01, 2011 04:21 PM
Red Marine Algae And Your Health.
Red marine algae refer to a large group of seaweeds that contain phycobiliproteins, which give them their red coloration. They are simple organisms in that they do not have complex tissues in contrast with terrestrial plants. Many species of red marine algae plays an important role in the formation of coral reefs as they secrete calcium carbonate as well as provide nutrition for other marine species. Like plants, they are capable of making their own food by way of photosynthesis. And like most other seaweeds, they are excellent sources of vitamins, minerals, and other healthy organic compounds.
Rhodophyta is the taxonomic classification of all red marine algae. It is oftentimes considered a part of the plant kingdom, but more recent definitions of plant suggest red algae belong to a kingdom of their own. Rhodophyta is one of the largest groups of algae, second only to green algae. It consists of up to 6000 aquatic species that are widely distributed in the tropical, temperate, and even frigid zones. These species usually take up residence along the coastal regions and significantly contribute to the distribution, abundance, and ecology of organisms found in the extended perimeter of each continent.
Seaweeds have become a part of the staple diet of many communities throughout history, and red marine algae are one of the best sources of human nutrition among all seaweeds. For thousands of years, different species of red algae have enjoyed significant presence in cuisines from all over the world. It is often consumed uncooked or added to salads. It is also an important ingredient in soups and stews. Ocean farmers have learned different techniques of domesticating crops of algae, and cultivation has been the solution to the growing demand of red marine algae in the past few decades.
Red marine algae have steadily grown in economic value since the 20th century. In addition to their historical culinary uses, their application now extends to medical science. Several organic compounds have been isolated from different species of red marine algae are now in wide use in the food and drug industries. For example, gelatinous substances are derived from agarophytes, any species of seaweeds that belong to rhodophyta. These substances are used in the production of beer, food preserves, ice cream as well as papers, fabrics, lubricants, and other personal care products.
Red marine algae have a special place in antiviral research. Many species are now identified to contain organic compounds that are of medicinal value against several viruses. Decades-long studies have come to a conclusion that sulfated polysaccharides derived from red marine algae have an inhibitory effect on replication of herpes simplex virus (HSV). There is good evidence that one class of sulfated polysaccharides called carrageenan offer some protection against transmission of herpes. Furthermore, recent studies have revealed that sulfated polysaccharides are potent inhibitors of HIV-1 in cell culture.
Red marine algae is an excellent source of nutrients found in the sea. Get some red marine algae and reap the benefits of this nutrient rich food today!
What is the Transfer Factor in Colostrum?
May 26, 2011 12:12 PM
Colostrum, Transfer Factor, And Your Health.
Transfer factor refers to any immune molecule found in the milk produced by the mammary glands in the first days after childbirth. It comprises a group of amino acids that are smaller than cells. Since its discovery in the 20th century, it has been suggested as a treatment for a host of diseases, including cancer, diabetes, infertility, fibromyalgia, Alzheimer’s disease, asthma, hepatitis, herpes, and HIV. It has grown in popularity in the past few years due to a resurgence of interest in natural remedies.
The quality of milk that mammals make in the last weeks of pregnancy is called colostrum, which is believed to be superior to ordinary milk. For one, it is lower in lipids and fats, but higher in proteins. More importantly, it contains antibodies called immunoglobulins, which are central to the identification of bacteria and viruses during infections. These antibodies alert the rest of the immune system to effectively deal with pathogens encountered for the first time. Colostrum contains transfer factors.
Like any other form of milk, colostrum is subjected to the digestion process when taken orally. The human gastrointestinal tract treats the carbohydrates, proteins, and even antibodies present in colostrums just like any other bioactive compounds, which are either absorbed or excreted. With the sole exception of transfer factors, everything else undergoes first pass metabolism in the liver. Transfer factors are so small that they pass through physiological screens and filters.
It is becoming common knowledge that transfer factors have antibiotic properties. Indeed they are one of the antibiotics that occur naturally in nature. They are produced by the mammary glands for the sole purpose of transferring the immunity of the mother to the newborn child. Newborns are completely sterile, making them especially susceptible several hours after birth. Transfer factors prepare the immune system of newborns against common pathogens the mother has encountered before.
One of the unique characteristics attributed to transfer factors in colostrum is its antiviral properties. Transfer factors were first observed to interfere with the rapid multiplication of rotavirus, which causes diarrhea in infants. More recent studies have looked into its medicinal potential against other viruses, such as human immunodeficiency virus and herpes. The scientific community has not come to a conclusion yet, with most of the antiviral researches on transfer factors being in their initial stages.
Transfer factors have been linked to faster muscle recover. Proponents believe that the group of proteins that constitutes transfer factors is capable of speeding up the healing rate of skeletal muscles after intense physical exertion. They raise the stress tolerance of individual cells amid harmful levels of aerobic metabolism. By so doing, they also make a viable treatment for muscle weakness and physical fatigue following continued exposure to stress without taking adequate time for recovery.
Boost Your Immune System with Colostrum Daily, you are never to young!
Boost Brain Chemistry, Lower Bad Cholesterol, And More
May 12, 2011 01:27 PM
What is Inositol Good for?
Inositol is an organic compound present in many plant-based foods. Popular nutritional sources of inositol include brown rice, wheat bran, whole grains, beans, nuts, and other foods rich in fiber. It is a polyphosphorylated carbohydrate that was once classified as an essential nutrient together with B-complex group of vitamins. It is an important component of signal transduction of cells, amplifying the strength of signals from the receptors on the cell surface to target molecules within the cytoplasm.
Cancer research on inositol is one of the most publicized. Fruits and vegetables that are known for their high fiber content also contain large amounts of inositol, which is believed to prevent the inactivation of DNA repair gene and protect the cells from mutation that lead to carcinogenesis. In laboratory studies it has shown great medicinal potential as a therapeutic remedy for various cancers. In addition, it has been extensively utilized in the treatment of psychiatric disorders.
Rebalances Brain Chemicals
Supplementation of high dose inositol has been observed to be beneficial to sufferers of mental illnesses. There have been numerous clinical trials focused on its effects on the chemical compounds found in the central nervous system, and early studies recorded that its mechanisms of action are similar to a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs.
A growing body of scientific literature is devoted to its purported role in the amelioration of anxiety disorder, panic disorder, obsessive-compulsive disorder, clinical depression, and bipolar disorder. It has been favored over some SSRIs because of its desirable results and absence of side effects. It has particularly benefited individuals diagnosed with obsessive compulsive disorder, with testimonies being largely positive. Also, it has been reported to also reduce frequency of panic attacks.
Lowers Bad Cholesterol
High-fiber diet has always been recommended to manage high cholesterol levels. It emphasizes the intake of whole grains, fruits, and vegetables. The same group of foods is rich in the carbohydrate inositol. In the latter half of the 20th century, it was discovered that inositol in fact contributes to the breakdown of fatty molecules, such as triglycerides, in the gastrointestinal tract and interferes with their absorption. More importantly, regular consumptions of inositol appear to reduce overall lipid levels in the blood. It is postulated that it blocks the metabolic pathway that integrates triglycerides in very-low-density lipoproteins, the immediate precursors of low-density lipoproteins, also known as bad cholesterol. By so doing, it not only lowers cholesterol and free fatty acids found in systemic circulation but also prevents cardiovascular diseases, such as atherosclerosis.
Many nutraceutical products that contain inositol are commercially touted to aid weight loss. Inositol has also been associated with the alleviation of digestive problems, most notably constipation. It is believed to soften the stool by attracting water as it works its way into the alimentary canal, and regular intake promotes regularity. Furthermore, it has been linked to hair growth as low levels of inositol have often been tied to hair loss.
Taking a inositol supplement can help you obtain all the inositol you need for your daily needs!
Liver Protection With Lipoic Acid and R-Lipoic Acid
May 05, 2011 03:42 PM
Early biochemistry studies pioneered by Linus Pauling associated R-Lipoic acid with orthomolecular medicine in that proponents argued that it biological roles provide protection against diseases. Succeeding research in the latter half of the 20th century supported its status as an essential nutrient, but more recent studies proved that all it is produced in vivo by almost all mammals, including human beings. In the past few years Lipoic acid has been strongly linked to glutathione as its supplementation appears to raise levels of endogenous glutathione.
Strengthens Antioxidant Defense
Lipoic acid is believed to raise the antioxidant capacity of the human body. Its biological roles benefits all cells, most notably hepatocytes, the cells that make up a significant fraction of the liver. For one, it affects productions of glutathione throughout the body. Glutathione is tripeptide that protects cells from the damage caused by reactive oxygen species, such as free radicals. Furthermore, it is a major transport of toxins found in the systemic circulation, facilitating their excretion through the urine.
R-Lipoic acid has been observed to be the form of Lipoic acid that is capable of activating nuclear factor erythroid-derived-2-like 2, commonly abbreviated as NFE2L2, the protein that binds to DNA sequences responsible for regulating the antioxidant defense of the human body. Proponents believe that oral intake of R-Lipoic acid produces more visible results than its racemic counterparts.
Displays Higher Bioavailability
Research on Lipoic acid is one of the most advanced, starting in the 20th century and spanning over 5 decades. It is widely accepted that the forms available in the market are not bioequivalent. Most of the studies in the 1950’s utilize the enantiomer S-Lipoic acid and R/S-Lipoic acid race mixture because they were cheaper to produce. Recent developments in chiral chemistry have increasing allowed for large-scale productions of R-lipoic acid.
Many scientists today believe that R-Lipoic acid is superior to racemic forms. Its rate and extent in availability after oral administration has been noted to be far better, and thus its efficacy is expected to be more remarkable. It is postulated that its higher bioavailability allows it to effective fill the roles of endogenous lipoic acid, not to mention manage to influence the master regulator of antioxidants.
Shows Vitamin-like Properties
The popularity of R-Lipoic acid lies in vitamin-like properties. Researchers are particularly enthusiastic about its purported benefits on human health, though more studies are needed. It is one of the organic compounds needed for enzyme function just like vitamins, and supplementation is believed to produce preventative benefits against diseases. Its pervasive roles at the cellular level enable it to affect energy metabolism, leading to healthy weight loss.
What is Myrrh and How Does it Boost My Health
April 25, 2011 04:22 PM
Myrrh And Your Health
Myrrh is one of the oldest herbal remedies in the East and the West. It had a strong presence in many religious traditions of the ancient world. It was even compared to gold in value at some time in history. Early physicians noted its antibacterial properties and added it to poultices and health tonics. Modern medicine has started to look into its medicinal potential in lowering cholesterol and blood sugar.
Inhibits Pain Chemicals
Myrrh is obtained from the plant species Commiphora myrrha, though there are other related species that produce the same resinous gum. It is native to the Levant and the surrounding regions. As its use were quite common during the ancient times, it spread to eastern countries, eventually reaching India and China, where it remains an important part of folk medicine practices to this day.
In addition to its pleasant aroma, myrrh was prized for its antiseptic and analgesic properties in the old days. It was one of the ingredients used by ancient Egyptians in the mummification of their dead. Throughout the centuries, myrrh has been used primarily as a perfume or wound salve. It has a soothing effect on lesions of body surfaces that seem to remove the perception of pain.
Improves Insulin Resistance
Earlier studies have noted the benefits of myrrh to patients suffering from diabetes, drawing on its uses in Ayurvedic and Unani medicine. In India, physicians that practice both conventional and Ayurvedic medicine have ascribed certain species of myrrh with properties that remove disorders of the circulatory system, notably high blood sugar. Myrrh decoctions are the usual herbal preparations, but it is also available as liniments, balms, salves, tinctures, and incense.
In one laboratory study, myrrh extracts appear to lower serum glucose levels. It is postulated that it ameliorates symptoms of metabolic syndrome by enhancing the effects of the hormone insulin. It increases the sensitivity of cells to insulin, even promoting faster glucose metabolism. In the Middle East, it is one of the mainstays of treatment for diabetes type 2.
Reduces Total Lipid Levels
Myrrh has been the subject of decades-long research on its role in the management of cholesterol. In the latter half of the 20th century, it was discovered that low-density lipoproteins play a major role in many cardiovascular diseases, such as atherosclerosis. The dichotomy of bad and good cholesterol hit the mainstream media to promote awareness of the lifestyle factors tied to cardiovascular diseases.
High-density lipoproteins are dubbed good cholesterol in contrast to low-density lipoproteins, or bad cholesterol. Low-density lipoproteins are actually involved in the formation of plaques within the blood vessel walls that leads to many complications. It has been observed that myrrh reduces total lipid levels in the blood by raising high-density lipoproteins and lowering low-density lipoproteins.
Give myrrh a try and experience its health beneficial properties for yourself!
How does Malic Acid help with Fibromyalgia?
February 09, 2011 01:18 PM
Malic Acid And Fibromyalgia
If you feel sensitized to pain by otherwise harmless stimuli, then you may be experiencing symptoms of fibromyalgia, which has been recorded to affect up to 4 per cent of the population worldwide. It is characterized by a feeling of weakness in the muscles of the limbs, conscious awareness of abnormal heartbeat, problems concerning bowel movement, and disturbances to sleep patterns. All of these are complaints reported to have been addressed by supplementation of malic acid.
The medical community remains inconclusive as to what causes fibromyalgia, some claiming it’s not a disease at all. While symptoms may not be necessarily medical signs, there are innumerable cases that describe complaints we collectively refer to as fibromyalgia. Throughout the past few decades, medical professionals around the world have considered these symptoms as one musculoskeletal disease whereas most neurologists have contended that fibromyalgia is attributable to the abnormalities within the nervous system. Today the American College of Rheumatology has charted nine paired tender points in an effort to describe the symptoms for this condition better.
Known Causes in Scrutiny
The most common symptoms of fibromyalgia more often than not appear simultaneously with stress-induced medical conditions such as chronic fatigue, anxiety disorders, and depression, but they are known to develop independently. A tissue in the brain responsible for long-term memory and spatial navigation called hippocampus have shown abnormalities among patients of fibromyalgia, thereby affecting sleep patterns, perception of pain, and related cognitive functions.
In the latter half of the 20th century it is postulated that serotonin leads to fibromyalgia. Serotonin being a neurotransmitter that governs mood, attention, and pain were found to be significantly decreased in the blood plasma and cerebrospinal fluid among patients who reported to experience this condition. That being said, the introduction of serotonin inhibitors used in treatment of depression has also shown alleviations of pain-related symptoms across the tender point index.
Malic Acid and Prognosis
Malic acid was discovered as a constituent of apple juice as early as the 18th century. Reduced levels of malic acid contribute to the maturity of fruits. In human beings it plays a fundamental role as an intermediate in a metabolic pathway that influences the chemical conversion of bioactive compounds like carbohydrates, fats, and proteins into carbon dioxide and water, which in turn convert the molecules contained in the cytoplasmic fluid of cells into energy generated in the mitochondria.
The availability of malic acid inside the human body modulates functional activities at the cellular level by speeding up the metabolism of bioactive compounds and consequently the production of energy in use by the cells. That being said, malic acid provides vitality to muscle cells, raising their endurance against stress. In addition, there have been reports that intake of malic acid help elevate levels of serotonin, leading to improved response to pain and better management of fibromyalgia.
For now, the tender point index is the primary diagnostic tool for evaluating fibromyalgia, and the use of malic acid has been recorded to reduce pain in these points.
Have you had your Malic Acid today?
Free Radicals and how to Combat Them!
November 30, 2010 02:41 PM
Vitamin C and E
Chances are you have heard about antioxidants. They’re everywhere: in the news, on the internet, and, of course, in our body. The first group of antioxidants that spurred the war against free radicals are Vitamin C and Vitamin E. As early as the 15th century, seafarers knowingly consumed citrus fruits in treatment of scurvy, which today we refer to as a disease caused by a deficiency of Vitamin C. On the other hand, intake of green leafy vegetables results in healthy cells in the body, touted lately as one of the benefits of Vitamin E. Since the latter half of the 20th century the term antioxidants have come into wide use, sparking a series of studies that led scientists and health professionals to a much more well-informed understanding of how important these vitamins are to human life.
Antioxidants and Free Radicals
Two things about biochemistry that have been a part of our growing concern about eating right are antioxidants and free radicals, which you might have learned outside the classroom. The human body deploy free radicals for the purpose of killing harmful microorganisms, but somehow these chemical entities get out of control. It should be noted that most known free radicals are short-lived, explaining how we survive as they are toxic to the body. When not properly disposed of, free radicals are one of the reactive oxygen species that create a chain reaction damaging everything, including DNA. The problem arises when the body fails to detoxify these reactive oxygen species, and then the latter run amok inside the body. This is when antioxidants come into the picture.
Vitamin C, Vitamin E, and Peroxyl Radicals
Vitamin C and Vitamin E are lipids that protect the interior of cells from the outside environment and play a role in storing energy for use by the human body. Different groups of lipids encompass several major chemical reactions in the body, including securing the proper functions of physiological communication lines. In a process called lipid peroxidation, peroxyl radicals go on a killing spree by depriving the lipids of electrons, which continues as they bring in more radicals. The human body make use of Vitamin C and Vitamin E to police the proliferation of lipid radicals in time to deactivate lipid radicals and avoid unwanted effects on cell membranes.
Ascorbate and Tocopherol as Co-Antioxidants
In chemical reactions, the body utilizes forms of tocopherol in Vitamin E and ascorbate ions in Vitamin C. These antioxidants work on the principle of pairing with peroxyl radicals, taking on radical forms, ascorbate and tocopherol, to stop the oxidation process initiated by free radicals. At the molecular level, ascorbate makes an ideal antioxidant as it does not react with oxygen and terminates harmful peroxyl radicals that continue to oxidize. Studies say that Vitamin C and Vitamin E are co-antioxidants in that ascorbate works with tocopherol. For example, when continuing oxidation damage lipids, tocopherol, Vitamin E, removes the harmful radicals, and ascorbate recycles Vitamin E back to its usable tocopherol form.
The Perfect Match
Alpha Lipoic Acid recycles both Vitamin C and Vitamin E because alpha lipoic acid is both water and fat soluble.
June 08, 2009 10:39 AM
For thousands of years, blue vervain has been used as an herbal remedy. The Chinese used this herb to treat malaria, dysentery, and congestion. It was also used during the middle Ages to help cure plagues. Blue vervain was also used by Native Americans as a natural tranquilizer for treating nervous conditions, along with female problems. In Germany, modern research has been found to support the use of blue vervain for the nervous system and for pain relief.
Because of its bitter taste, vervain is used by herbalists to improve digestion. Additionally, this herb was used to treat people with depression and spastic pains in the gastrointestinal tract. Blue vervain was also used as a mild diaphoretic and for all manner of female reproductive system problems that are associated with melancholy or anxiety. Physicians in the United States during the early 20th century believed that vervain may be helpful for mild digestive problems. This herb also had a reputation of being a traditional remedy for stimulating the production of breast milk. Although the active constituents of vervain have not been thoroughly demonstrated, it is believed that glycosides such as verbenalin and acucubin, as well as a volatile oil may be the key contributors to its activity.
Additional research shows that blue vervain has pain-relieving and anti-inflammatory properties that can help to relieve respiratory inflammation. These properties are also calming for coughs. This herb works to fight mucus, especially for coughs that are associated with colds. Dr. Edward E. Shook, a herbalist, recommended using blue vervain to treat all diseases of the spleen and liver. This herb is also used to restore circulation and alleviate menstrual symptoms, epilepsy, indigestion, and dyspepsia.
A vervain tea made from leaves and flowers can be prepared by adding one to two teaspoons to a pint of hot water. This is then left to steep, covered for ten to fifteen minutes. Doctors typically recommend that a person takes three cups each day. Because the taste of the tea is somewhat disagreeable, the majority of people prefer to take this extract in a tincture or pill form. A tincture of one to two teaspoons, three times daily, is also suggested to consume this extract.
No adverse effects of vervain have been reported to this date. However, vervain should be avoided during pregnancy. Even though it was used traditionally during the last two weeks of pregnancy to facilitate labor, if it is used during pregnancy, one should only do so under the guidance of a healthcare professional that is experienced in herbal medicine.
The entire herb is used to provide alterative, anti-inflammatory, antiperiodic, antispasmodic, diaphoretic, expectorant, nervine, and purgative properties. The primary nutrients found in blue vervain include calcium, manganese, and vitamin C and E. Primarily, blue vervain is extremely beneficial in dealing with asthma, bronchitis, poor circulation, colds, colon problems, congestion, convulstions, coughs, fevers, flu, gastric disorders, indigestion, insomnia, liver disorders, lung congestion, nervous conditions, pneumonia, seizures, upset stomach, sore throat, uterine problems, and worms.
Additionally, this herb is extremely helpful in treating catarrh, constipation, diarrhea, dysentery, earaches, epilepsy, gallstones, headaches, kidney problems, malaria, menstrual symptoms, excessive mucus, pain, skin diseases, sores, and spleen ailments. For additional information on the many beneficial effects of blue vervain, please contact a representative from your local health food store. Always purchase name brands to ensure quality and purity of the product you buy.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Blue vervain is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
DHA for Attention and Focus
September 29, 2008 05:33 PM
Attention deficit/hyperactivity disorder emerged in scientific research at the turn of the 20th century when Dr. George Still was introduced to a disobedient, troubled, nine year-old boy. Today, research still just touches the edge of this serious disorder, but our understanding has steadily grown throughout the 20th century. Dr. Still believed that ADHD is not just the result of bad parenting, but also of some sort of condition in the brain. The symptoms that comprised ADHD were considered minimal brain dysfunction or minimal brain damage in the 1940s or 1950s, while others called it hyperactivity. By 1987, scientists were referring to the condition as ADHD.
Today, no one has yet to pinpoint the exact cause of ADHD, but there has been some interesting research that has lead to the discovery of many different facts. Identical twins are much more likely than fraternal twins to both suffer from ADHD, as identical twins share genetic material, causing researchers to believe that ADHD may have a genetic component. A study of adults with ADHD showed that ADHD brain cells were less active by eight percent and used glucose less effectively in the areas of the brain that involved attention control. About seventy percent of ADHD children continue having ADHD when they become adults. Additionally, a study found that fifty-seven boys with ADHD suffered from a slight structural abnormality in the brain, with the prefrontal cortex, caudate, nucleus, and globus pallidus being slightly smaller on the right side than in fifty-five boys who didn’t suffer from this disease. All of these areas are parts of the brain that are believed to inhibit our actions.
The American Psychiatric Association says that children can have ADHD if they have six or more of the following symptoms of hyperactivity, impulsivity, or inattention for six months or longer. Other possible symptoms include: frequently not paying close attention to details; frequently having trouble staying focused on tasks; frequently not following through on instructions; frequently having difficulty organizing duties and activities; frequently failing to listen when directly spoken to; frequently avoiding or hesitating to be involved in tasks requiring continued mental effort; frequently losing objects needed for duties or activities; frequently distracted by external stimuli; and frequently forgetting daily activities.
Other symptoms of hyperactivity and impulsivity would include: frequently fidgets with hands or feet; frequently squirming while sitting down; frequently leaves seat in places where remaining seated is the accepted norm; frequently running around or climbing in places that are inappropriate; frequently having difficult playing quietly; frequently appearing on the go; frequently speaking excessively; frequently blurting out answers before questions are completed; frequently having trouble waiting his turn; and frequently interrupting conversations or games with others.
The most commonly prescribed treatment for ADHD is medication, often being Ritalin, which is a stimulant that helps to enhance the effect of the brain chemicals that help nerve and brain cells to receive messages from each other. Ritalin can help ease the suffering of a child with ADHD, making them more attentive and less aggressive. However, there are many drawbacks to the use of Ritalin, which include it being a form of amphetamine, becoming a popular drug to abuse, having many significant side affects, and being psychologically addictive. Natural alternatives are available such as Dha or essential fatty acids which are suppose to promote proper brain function.
July 28, 2008 03:47 PM
As a society we are undoubtedly suffering from a lack of dietary fiber. Although it is true that we are constantly warned that diets low in fiber can actually kill us, most of us continue eating the way we always have. Our diets are full of empty calories, refined foods, sugar, and very little when it comes to whole foods. As far as fiber is considered, many of us believe that a daily bowl of cereal is more than enough fiber. Sadly, the food in many of our houses consist of white flour products, cooked and canned vegetables, cookies, chips, all of which are fiber-less and artificially altered from their original state, making them less and less like actual food. The typical American eating habits have led to issues of chronic constipation, intestinal gas, bowel disorders, and a variety of infections all leading to colon cancer.
If we want to increase our fiber intake, we must first recognize what exactly fiber is, where it is found, and how it works. A lot of us would not even recognize certain foods in their whole, natural state. For the most part, whole foods from plants offer us a great amount of dietary fiber. Although food producers add natural and synthetic fiber to foods, they cannot improve on the natural fiber that is found in plants. Since ancient times, whole grains have been considered staples of the diet were consumed by the lower-class societies who could not afford the fatty, sweet, high protein diets of the upper class.
It is no coincidence that as our intake of fiber decreased, certain bowel diseases including colon cancer and diverticulitis increased. Physicians of the 19th and early 20th centuries prescribed the worse possible treatment for these bowel disorders, which was eating a bland, highly refined diet. Now today, there are over 85,000 cases of colon cancer that have diagnosed in our country each year, with the number growing.
The science of fiber began in the early 20th century, when studies were initiated on the laxative action of bran, as well as other subjects. Researchers in the sixties noticed that certain diseases, which were devastating our societies, were relatively rare in third world communities. It was concluded that all the diseases of our civilization were caused by our over-consumption of sugar and refined carbohydrates. Thankfully, the medical establishment has become more aware nowadays.
Today we know that the condition of the colon is related to all body systems and can influence numerous chronic diseases, which include cancer. A bacterial flora imbalance may be the cause of many diseases, with this condition being referred to as autointoxication. Autointoxication is caused by the array of poisons that an unhealthy colon can harbor and is based on the belief that what you eat determines the kind of bacteria which will inhabit your bowel.
It has been found that we rarely replenish the good flora by eating good sources of acidophilus and routinely kill the friendly bacteria by using antibiotics and other drugs and alcohol. This creates the perfect habitat for pathogenic bacteria to flourish and leaving our colons as a toxic waste dump. Intestinal microflora can be altered by increasing your intake of dietary fiber in as little as two weeks. Since fiber affects several vital metabolic processes, eating enough of it is extremely important in maintaining good health and preventing disease.
Which Calcium is Best?
October 17, 2006 03:52 PM
Customers walking into a health food store today are faced with a vast array of calcium supplements. They might ask: which one should I pick? Which one is best? Not easy questions to answer. All calcium forms will accomplish the same task: providing your body with a nutrient that it needs to build healthy bones and teeth; however, which form of calcium has the features that you want in a calcium supplement? Looking at shelves of calcium products is kind of like shopping for a car; there are many makes and many models—some are basic and others are more sophisticated.
Fortunately, there are many forms of calcium to satisfy your needs. Like the car lot, a health food store offers many options; therefore, you have to select a calcium product that consumers will feel confident in taking regularly and that will provide the most benefit.
Some consumers have done research and will come armed with information. They have already made choices based on advertising, word-of-mouth or an article they have read. They already know the form of calcium they want, be it a “Ferrari” or a “Ford.” If the client doesn’t have a specific preference: asking these basic questions will help in the selection process:
1. Do you prefer tablets, capsules, softgels, liquid or powder?
2. Do you have high or low stomach acid?
3. Do you have absorption issues?
What is calcium?
Calcium (Ca) is one of the most important minerals found in our bones and teeth—99 percent of body calcium is found there. But the calcium molecule does not like to travel alone and, in its more basic state, it comes bounded to carbon (C), Oxygen (O), and/or hydrogen (H) molecules or in more complex form, it is bonded to organic or amino acids that act as stabilizing carriers. On most labels, the amount of calcium listed actually indicates the pure or elemental calcium because it is that amount of the calcium that is deemed important to our daily supplementation, not the complex of the materials with which it is bonded.
Where does calcium come from?
Other than the calcium found in bone, the only natural form of calcium found in nature is calcium carbonate, a calcium molecule bonded to one molecule of carbon and three molecules of oxygen (CaCO3). One of the most common minerals on the face of the earth, calcium carbonate is called calcite, aragonite or vaterite by geologists. In its geological form, it constitutes approximately four percent, by weight, or the earth’s crust.
Commercial sources of calcium carbonate used to make supplements are: limestone, dolomite, oyster cell, egg shell, coral and sea water (have you ever seen that white deposit left by hard water? That’s mostly calcium carbonate). Calcium carbonate is the starting material for all other forms of calcium supplements. From this starting material, calcium can be reduced to more concentrated forms, such as oxide or hydroxide or it can be chelated (bonded) to organic acids and amino acids to help support enhanced absorption.
Lets look more closely at the different forms of calcium that are available as supplements.
Calcium Oxide (CaO): this form is 71 percent elemental calcium and is also called “lime” commercially. This is one of the oldest and most inexpensive forms of calcium used in a variety of commercial applications and it is occasionally used in supplements where space and price are a factor. It sometimes can be found in inexpensive mass market calcium/mineral combinations or multivitamin/mineral products and in a unique algal calcium from Japan. Unfortunately, CaO is a strong alkali that may cause stomach distress, which is why it isn’t often used in health food supplements.
Calcium Hydroxide (CaHO): at 54 percent elemental calcium, it is the next highest source of elemental calcium and is also known commercially as “slaked lime.” It is used where space is an issue. Although it is also a strong alkali, it is more stable than calcium oxide. It is most often used as a component of multi-mineral formulations or in addition to other forms of calcium (i.e., calcium citrate) to provide potency where space is an issue. It is not often used as a single ingredient in health food supplementation. This is for people who want a high dosage of calcium from a minimum amount of pills in multi-mineral formulas.
Calcium Carbonate (CaCO3): at 40 percent elemental calcium, it is the most widely used form of calcium in single ingredient calcium supplements as well as combination supplements. Inexpensive and an abundant source of elemental calcium, it is the only form of calcium found in nature outside of bone. It is the primary form of calcium used in the mass market and in antacid products. This is for people who have high stomach acid and who need a buffering type of calcium. Also for people who want a high dose of calcium in a minimum amount of pills.
Calcium Citrate: at 21 percent elemental calcium, it is one of the most popular forms of calcium supplements in the health food market as well as the mass market. This calcium salt does not lower stomach acid as much as calcium carbonate. This calcium salt is usually recommended for people who have low stomach acid, have had stomach surgery or who need a form of calcium that will not lower their stomach acid further.
Calcium Gluconate and Lactate: these two forms of calcium are high soluble. Since the amount of elemental calcium is much lower (9 percent and 13 percent respectively), they are used more often in powder form and mixed with liquids or food. When mixed in a beverage, the calcium is already dissolved and is ready to be absorbed. This is the best calcium salt for people who have overactive bowels, who have trouble swallowing pills or who don’t like the taste of pre-formed liquid calcium supplements. These calcium powders can be mixed in juices or smoothies or added to food as they are virtually tasteless.
Calcium Orotate and Asporotate: In the mid 20th century, Dr. Hans Nieper, a German scientist, advanced a theory that orotic and aspartic salt forms of calcium are transported directly to cell membranes for better absorption. The Solaray brand developed an asporotate formula, which combines three organic acids: aspartic acid (-Asp), orotic acid (-oro) and citric acid (-tate) into one product. The asporotate formula has become one of the most popular calcium formulas and is exclusive to the Solaray brand. This product is for customers who appreciate the idea of combining the enhanced absorbability of three organic acids into one. Aspartate and citrate are also part of the krebs (energy) cycle and are natural to the body’s metabolic systems and, according to Neiper, calcium Orotate and Aspartate are mineral transporters that enter into the cells to facilitate enzymatic actions rather than being extra-cellular. For people who believe that intracellular calcium is of importance, calcium Orotate and asporotate may be good choice.
Calcium Hydroxyapatite: this is another “natural form of calcium usually as a mineral ash form bovine source bone. Bone meal is also a form of calcium from bovine bone. These forms of animal derived calcium are for customers who want a source that is closest to their own bone matrix. Not for vegetarians.
Calcium Amino Acid Chelates (*HVP): this form is calcium carbonate bonded (Chelated) to a form of amino acid complex such as whole rice concentrate or other grain source. This form is for customers who want the additional bioavailability of amino acids.
Calcium AEP: Another form of calcium endorsed by Dr. Hans Nieper who theorized that calcium would cross the cell membranes more readily when it was combined with phosphatidyl ethanolamine or Amino Ethanol Phosphate (AEP), a nutrient found in nerve sheaths. This highly specialized form is for very educated customers who are proponets of Hans Niepers theory.
So, which form is best?
Calcium, like cars, comes in a variety of forms. Isn’t it wonderful that we have so many choices? The point is, there is no best one, there are only individual choices. Although we have our favorites, taking a calcium supplement, regardless of which one it is, should:
Our primary concern when choosing a calcium supplement should be to provide our body with the right amount of calcium daily so that our skeleton and teeth can maintain proper mineralization and strength as the cells continuously break down and rebuild. The type of calcium complex we prefer is entirely up to us.
*HVP = Hydrolyzed Vegetable Protein
The Skinny on Fats - Omega-3, Omega-6, Omega-7, Omega-9
October 04, 2006 04:53 PM
Health experts keep changing the storey on fats. First we were told that polyunsaturated fats were better than saturated fats. Then it was discovered that refined polyunsaturates were favorite targets for free radical attack. Next, monounsaturated fats took center stage and have remained in the spotlight ever since. The Mediterranean Diet, with its high intake of olive and other oils high in monounsaturates, offers several important safeguards against cardiovascular disease, cancer and overall mortality. (Laino, de Largeril, Kokkinos, Trichopoulou). While monounsaturated fats are important for maintaining optimum health and smooth supple skin, it’s the kind of fatty acids and antioxidants they contain that make up the real story.
Dark green unrefined “extra Virgin” olive oil has a delightful full bodied flavor due to its natural antioxidants. Not only are the oils of various olive cultivars distinctive, they all help fight arterial plaque buildup. (Visioli) Olive oil has a long history in Europe as both food and medicine, and carbon dating of seeds found in spain have shown that the use of olive oil dates back 8,000 years. Gourmet chefs usually prefer particular oils for various uses in making dressing, marinades, and sauces for dipping. Olive orchards have now achieved a status second only to that of vineyards.
Macadamia nut oil is another designer oil that is fast gaining a reputation among chefs and health experts. The nuts originated in Australia where they were staples in the diets of the Aborigines. In 1881, they were introduced in Hawaii and in the 20th century, made their way to California where several cultivars are now grown. Like olive oil, macadamia nut oil is rich in antioxidants and contains the highest levels, greater than 80 percent monounsaturates, primarily polmitoleic (omega-7) than other oils. (Hiraoka-Yamamoto)
Macadamia nut oil products found in mass market are typically refined, with many of the antioxidants removed. The highest levels of antioxidants in macadamia nuts are found in the shells. During cold processing, some of these antioxidants leech into the oil, increasing its antioxidant potential. (Quinn) unrefined and organic oils have a golden color, pleasing nutty aroma and buttery flavor. Scientists have found that macadamia nut oil lowers, LDL cholesterol and triglycerides, and may help prevent stroke. (Yamori, Colquhoun) It is delightful on vegetables, in soups, on popcorn, and as a replacement for butter in baking.
The essential oils (Fish oils, flaxseed, GLA, DHA), which are available as liquid and packaged in black bottles, must be stored in the Refrigerator even when they have not been opened. You cannot heat or cook with them. Essential fatty acid supplements are convenient to take and have specific therapeutic value.
Cardiovascular and Nerves – Consumers have been advised to eat more fish rich in Omega-3 to reduce their risk of cardiobascular disease. However, experts worry that eating several servings of fish each week may not be safe especially during pregnancy, dursing or trying to conceive. Instead they recommend fish oil supplements such as Omega-3 from Algae , Fish oil, and Omega-6 Evening Primrose and Borage oils.
Pain Relief – A blend of cetylated fatty acids including myristate, myristoleate, laurate, oleate, palmitate and palmitoleate appear to be effective in reducing inflammation and pain in arthritis and other inflammatory conditions. (Vanderhaeghe) In a San Diego California study of sixty-four patients with osteoarthritis, an oral preparation of cetylated fatty acids known as celadrin significantly improved range of motion and flexibility. (Hesslink)
Two other studies of osteoarthritis patients at the University of Connecticut, using a topical preparation of Celadrin, showed significantly greater knee stability, improvement in stair climbing ability, balance and strength, and reduction of pain. (Kraemer)
Animal studies at the University of Minnesota have shown that cetylated fatty acids administered either topically or orally are well tolerated and rapidly dispersed throughout the body. (Gallaher) Doses for the oral form are 1500mg three times a day. The topical cream is applied two to four times a day.
July 12, 2005 09:52 AM
HISTORY or Milk Thistle
Natural substances which afford us protection from toxins and potential carcinogens have recently come to the fore front of scientific attention. Compounds known as antioxidants, which can help minimize the damaging effects of chemical stru c t u res called free radicals, are extensively used today. One of these protectant substances is not as familiar to most people as vitamin C or beta-carotene. It is an herb called Milk Thistle and it has some extraordinary protective properties. Milk Thistle, also known as Silymarin has enjoyed a long history of use in European folk medicine. Centuries ago, Romans recognized the value of this herb for liver impairments. They routinely used the seeds and roots of the plant to restore and rejuvenate a diseased liver. Pliny the Elder, an ancient Roman, re c o rded how the juice of Milk Thistle, when mixed with honey was used for carrying off bile. Dioscorides extolled the virtues of Milk Thistle as an effective protectant against snake bites. The genus silybum is a member of the thistle tribe of the daisy family. Two species of the plant exist and both are native to southern Europe and Eurasia. Plants which grow in the Southern United States actually have more potent seeds than their European and Asian counterparts. Milk Thistle is a stout and sturdy looking plant, which can grow up to 12 feet tall. The flower heads can expand to six inches in diameter and are a vivid purple color. They usually bloom from June to August. Very sharp spines cover the heads. The leaves are comprised of hairless, milky bands, and when young, are quite tender. Historically, the seed of Milk Thistle was used as a cholagogue which stimulated the flow of bile. The seed was also used to treat jaundice, dyspepsia, lack of appetite and other stomach disorders. Homeopathic uses included:
peritonitis, coughs, varicose veins and uterine congestion. While tonics were sometimes made from the leaves of Milk Thistle, the most valuable part of the plant was contained in its seeds.
Milk Thistle is also known as Marian Thistle, Wild Artichoke, Variegated Thistle or St. Mary’s Thistle. Reference to Milk Thistle as “Vi rgin Mary” stems from its white milky veins. Legends explained that these veins were created when Mary’s milk fell on the thistle. Subsequently, a connection between the herb and lactation arose, which has no scientific basis for its claims. Milk Thistle is frequently confused with Blessed Thistle, which does act to stimulate the production of mother’s milk. Gerarde, a practicing herbalist in 1597, said that Milk Thistle was one of the best remedies for melancholy (liver related) diseases. In 1650, Culpeper wrote of its ability to remove obstructions in the liver and spleen. In 1755, Von Haller recorded that he used Milk Thistle for a variety of liver disorders. Subsequently, Milk Thistle became a staple agent for the treatment of any kind of liver aliment. European physicians included it in their written materia medica. Unfortunately, for an extended period during the 18th century, the herb was not stressed, however in 1848, Johannes Gottfried Rademacher rediscovered its medicinal merits. He recorded in great detail how Milk Thistle treated a number of liver ailments and spleen disorders. His research was later confirmed in medical literature. In the early 20th century, Milk Thistle was recommended for female problems, colon disorders, liver complaints and gallstones. Almost every significant European pharmaceutical establishment listed Milk Thistle as a valuable treatment. In recent decades, Milk Thistle has been primarily used as a liver tonic and digestive aid. Nursing women who wanted to stimulate the production of their milk used Milk thistle as a traditional tonic. As mentioned earlier, modern day medical science now refutes this particular action of Milk Thistle, however, its benefit to the liver has been confirmed.
German herbalists have routinely used Milk Thistle for treating jaundice, mushroom poisoning and other liver disorders. This therapeutic tradition contributed to modern German research into Milk Thistle, resulting in its use as a widely prescribed phytomedicine for liver disease. Silymarin or Thisilyn, as it is also known, is a relatively new nutrient in the United States. Since 1954, scientists have known the Milk Thistle contained flavonoids, however, it wasn’t until the 1960’s that they discovered the just how unique silymarin is. Silymarin was considered an entirely new class of chemical compound, and its therapeutic properties continue to impress the scientific community.
HAWAIIAN NONI (Morinda citrifolia)
July 11, 2005 08:50 PM
In a time when we are more concerned than ever with issues of health, a tried and true tropical herb called noni needs t o be added t o our list of the best natural remedies. It susage over hundreds of years supports it s description as a veritable panacea of therapeutic actions. At this writing, noni continues to accrue impressive medicinal credentials, and its emergence as an effective nat ural healing agent is a timely one. Amidst rising cancer rates, the high incidence of degenerative diseases like diabetes, and the evolution of ant ibiotic resist ant bacteria and new viral strains, herbs like noni are sought after for their natural pharmaceutical properties. Unquest ionably, all of us want to know how to:
Indian Mulberry (India), Noni (Hawaii), Nono (Tahiti and Raratonga), Polynesian Bush Fruit, Painkiller Tree (Caribbean islands), Lada (Guam), Mengkudo (Malaysia), Nhau (Southeast Asia), Grand Morinda (Vietnam), Cheesefruit (Australia), Kura (Fiji), Bumbo (Africa) Note: This is only a small sampling of vernacular names for Morinda citrifolia. Almost every island nation of the South Pacific and Caribbean has a term for this particular plant . This booklet will refer to the herb mainly as “ noni” or M. citrifolia, and is referring primarily to Hawaiin noni.
The parts of the noni plant most used for their medicinal and nutritional purposes are the fruit, seeds, bark, leaves, and flowers. Virtually every part of the noni plant is utilized for its individual medicinal properties; however, it is the fruit portion that is regarded as its most valuable. The seeds have a purgative action, the leaves are used to treat external inflammations and relieve pain, the bark has strong astringent properties and can treat malaria, the root extracts lower blood pressure, the flower essences relieve eye inflammations and the f ruit has a number of medicinal actions.
Morinda citrifolia is technically an evergreen shrub or bush, which can grow to heights of fifteen to twenty feet . It has rigid, coarse branches which bear dark, oval, glossy leaves. Small white fragrant flowers bloom out of cluster-like pods which bear creamy-white colored fruit. The fruit is fleshy and gel-like when ripened, resembling a small breadf ruit . The flesh of the fruit is characterist ically bitter, and when completely ripe produces a rancid and very dist inctive odor. Noni has buoyant seeds that can float formont hs in ocean bodies. The wood of the inflammatory, astringent, emollient, emmenagogue, laxative, sedative, hypotensive (lowers blood pressure) , blood purif ier, and tonic.
Noni has various chemical constituents. First, it has an impressive array of terpene compounds, three of which—L. Asperuloside, aucubin, and glucose— have been identified by their actyl derivatives. Both caproic and caprylic acids have been isolated.1 Second, bushfruits, a category of which noni fruit is a member, are also considered a good source of vit - amin C.2 Third, Hawaiin noni has been linked to the synthesis of xeronine in the body which has significant and widespread health implications. Last , the alkaloid cont ent of the noni fruit is thought to be responsible for its therapeutic actions. Alkaloids exhibit a wide range of pharmacological and biological act ivitiesin the human body. They are nitrogencontaining organic compounds which can react with acids to form salts and which are the basis of many medicines. The following is an in-depth chemical analysis of each plant part and it s chemical constituents.
discovered an alkaloid in the Hawaiin noni fruit which he calls proxeronine and which he believes has appreciable physiological actions by acting as a precursor to xeronine, a very crucial compound (see later sections) . In addition, a compound found in the fruit called damnacanthol is believed to help inhibit cert ain viruses and cellular mutations involved in cancer.
ROOT AND ROOT BARK
Recent surveys have suggested that noni fruit exerts antibiotic action. In fact, a variety of compounds which have antibacterial properties (such as aucubin) have been identified in the fruit.5 The 6-Dglucopyranose pentaacet ate of the fruit extract is not considered bacteriostatic.6 Constituents found in the fruit portion have exhibited ant imicrobial action against Escherichia coli, Salmonella typhi (and other types) , Shigella paradysenteriae, and Staphylococcus aureaus. Compounds found in the root have the ability to reduce swollen mucous membrane and lower blood pressure in animal studies. Proxeronine is an alkaloid constituent found in Hawaiin noni fruit which may prompt the production of xeronine in the body. It is considered a xeronine precursor and was discovered in noni fruit by Dr. Ralph M. Heinicke. He has theorized that this proenzyme can be effective in initiating a series of beneficial cellular reactions through its involvement with the integrity of specific proteins. He points out that tissues contain cells which possess certain recept or sites for xeronine. Because the reactions that can occur are so varied, many different therapeutic actions can result when xeronine production escalates, explaining why Hawaiin noni is good for so many seemingly unrelated disorders. Damnacanthol is another compound contained in the fruit of the Hawaiin noni plant which has shown the ability to block or inhibit the cellular function of RAS cells, considered pre-cancerous cells.
Body Systems Targeted
The following body systems have all been effec-freeze-dried capsules, dehydrated powder or fruit, and oil. Noni plant constituents are sometimes offered in combination with other herbs. Some products contain a percent age of the fruit, bark, root and seeds for their individual therapeutic properties.
Extracts of M. citrifolia are considered safe if used as directed; however, pregnant or nursing mothers should consult their physicians before taking any supplement . High doses of root extracts may cause constipation. Taking noni supplements with coffee, alcohol or nicotine is not recommended.
Ideally, noni extracts should be taken on an empty stomach prior to meals. The process of digesting food can interfere with the medicinal value of the alkaloid compounds found in Hawaiin noni, especially in its fruit . Apparently, stomach acids and enzymes destroy the specific enzyme which frees up the xeronine compound. Take noni supplements without food, coffee, nicotine or alcohol. Using supplements that have been made from the semi-ripe or light - green fruit is also considered preferable to the ripe, whit ish fruit .
NONI: ITS USE AND HISTORY
Noni is a tropical wandering plant indigenous to areas of Australia, Malaysia and Polynesia. It is considered native to Southeast Asia although it grows from India to the eastern region of Polynesia. Morinda citrifolia has a long history of medicinal use throughout these areas. It is thought to be the “most widely and commonly used medicinal plant prior to the European era.” 7 Centuries ago, the bushfruit was introduced to native Hawaiians, who subsequently called it “noni” and considered its fruit and root as prized medicinal agents. Among all Polynesian botanical agents of the 19th and 20th centuries, Hawaiin noni has the widest array of medical applications. Samoan and Hawaiian medical practitioners used noni for bowel disorders (especially infant diarrhea, constipation, or intestinal parasites) , indigestion, skin inflammation, infection, mouth sores, fever, contusions and sprains. Hawaiians commonly prepared noni tonics designed to treat diabetes, stings, burns and fish poisoning.8 The herb’s remarkable ability to purge the intestinal tract and promote colon health was well known among older Hawaiian and Tahitian natives and folk healers. Interestingly, field observations regarding its repu-remarkable healing agent .
Wonder Herb of Island Folk Healers
Common to t he thickets and forests of Malaysia and Polynesia, and the low hilly regions of the Philippine islands, noni has been cultivated throughout communities in the South Pacific for hundreds of years. Its Hawaiian use is thought to originate from inter-island canoe travel and settlement dating to before Christ . Its hardy seeds have the ability to float which has also contributed to its distribution among various seacoasts in the South Pacific region. Historical investigation has established the fact that some of Hawaii’s earliest settlers probably came viaTahiti. For this reason, Tahitian herbal practices have specific bearing on the herbal therapeutics of islands to the nort h. The very obvious similarities between the Hawaiian vernacular for herbal plants like noni and Tahitian names strongly suggests the theory of Polynesian migrations to Hawaii. Cultures native to these regions favored using Morinda citrifolia for treating major diseases and ut ilized it as a source of nourishment in times of famine.9 Noni fruit has been recognized for centuries as an excellent source of nutrition. The peoples of Fiji, Samoa and Rarat onga use the fruit in both its raw and cooked forms.10 Traditionally, the fruit was propicked before it was fully ripe and placed in the sunlight . After being allowed to ripen, it was typically mashed and its juice extracted through a cloth. Noni leaves provided a veget able dish and their resiliency made them desirable as a fish wrap for cooking.
Noni’s Medical Reputation
Elaborate traditionalrituals and praying rites usually accompanied the administration of noni. Int erestingly, cultures indigenous to the Polynesian islands had a significant understanding of their flora. For example, native Hawaiians maint ained a folkmedicine taxonomy t hat was considered second to none.11 Noni was not only used for medicinal purposes but for its food value, for clot hing and for cloth dyes as well. Research indicates that noni was among the few herbal remedies that islanders considered “ tried and true.” In Hawaii, trained herbal practitioners reserved the right to prescribe plant therapies.12 Records indicate that Hawaiian medical practices were based on extensive and very meticulous descriptions of symptoms and their prescribed herbal treatments. Dosages were controlled and the collection and administration of plant extracts was carefully monitored.13 In addition to Morinda, it was not uncommon for these herbal doctors to also recommend using In regard to its application for common ailments, Hawaiians and other island communities traditionally prescribed noni to purge the bowel, reduce fever, cure respiratory infections such as asthma, ease skin inflammations, and heal bruises and sprains. In other words, noni was widely used and highly regarded as a botanical medicine.
A Timely Reemer gence
Today, the natural pharmaceutical actions of the chemical constituents contained in noni are scientif-ically emerging as valuable bot anical medicines. Tahitian “nono” intrigued medical practitioners decades ago; however, due to the eventual emergence of synthetic drugs, interest in this island botanical diminished until recent years. Ethnobot anists are once again rediscovering why Hawaiian people havet reasured and cultivat ed Morinda citrifolia for generations. Noni is now finding its way into western therapeutics and is referred to as “ the queen” of the genus Rubiaceae. Its ability to reduce joint inflammation and target the immune system have made it the focus of the modern scientific inquiry. Dr. Ralph Heinicke has conducted some fascinating studies on the chemical constituents of the Hawaiin noni fruit. His research centers on the proxeronine content of the fruit juice and how it profoundly influences human physiology. In addition, scientific studies investigating noni as an anti-cancer agent have been encouraging. It s conspicuous attributes and varied uses have elevat edits status to one of the best of the healing herbs. Today Morinda citrifolia is available in liquid, juice, freezedried capsules, or oil forms, and is considered one of nature’s most precious botanicals.
TRADITIONAL USES OF NONI
Throughout tropical regions, virtually every part of Morinda citrifolia was used to treat disease or injury. Its curative properties were well known and commonly employed. PatoaTama Benioni, a member of the Maoritribe from the Cook Islands and a lecturer on island plants explains: Traditionally Polynesians use noni for basically everything in the treatment of illness. Noni is a part of our lives. Any Polynesian boy will tell you he’s had exper ience with it . We use juice from its roots, its flowers, and its fruit... my grandmother taught me to use noni from the roots and the leaves to make medicine for external as well as internal use, and for all kinds of ailments, such as coughs, boils, diseases of the skin, and cuts.15
decoctions to stimulate delayed menst ruation.
XERONINE: THE SECRET OF NONI?
One informed professional on the subject of noni is Dr. Ralph Heinicke, a biochemist who has researched the active compounds of noni fruit for a number of years. He discovered that the Hawaiin noni fruit contains an alkaloid precursor to a very vital compound called xeronine. Wit hout xeronine, life would cease. In Dr. Heinicke’s view, noni fruit provides a safe and effective way to increase xeronine levels, which exert a crucial influence on cell health and protction. His research suggests that the juice from the M. citrifolia fruit contains what could technically be considered a precursor of xeronine—proxeronine. This compound initiates the release of xeronine in the intestinal tract after it comes in contact with a specific enzyme which is also contained in the fruit .
Because proteins and enzymes have so many varied roles within cell processes, the normalization of these proteins with noni supplemenation could initiate avery wide variety of body responses and treat many disease condit ions. Proteins are the most important catalysts found in the body. The beauty of obtaining a precursor to xeronine from the noni fruit is that the body naturally decides how much of this precursor to convert to xeronine. Disease, stress, anger, trauma and injury can lower xeronine levels in the body, thus creat ing a xeronine deficit . Supplementing the body with noni fruit is considered an excellent way to safely and naturally raise xeronine levels. It is the research and theories of Dr. Heinicke which have made the juice of the Hawaiin noni fruit a viable medicinal substance. He writes: Xeronine is analkaloid, a substance the body produces in order to activate enzymes so they can function properly. It also energizes and regulates the body. This par-ticular alkaloid has never been found because the body makes it, immediately uses it, and then breaks it down. At no time is there an appreciable, isolable amount in the blood. But xeronine is so basic to the functioning of proteins, we would die without it . Its absence can cause many kinds of illness.17 Because so many diseases result from an enzyme malfunction, Dr. Heinicke believes that using the noni fruit can result in an impressive array of curative applications. Interestingly, he believes that we manufacture proxeronine while we are sleeping. He proposes t hat if we could constantly supply our bodies wit h proxeronine from other sources, our need to sleep would diminish.18
How an herb is processed is crucial to how beneficial it is: this is especially true of noni, with its unique enzymes and alkaloids. Morinda citrifolia should be picked when the fruit is turning from its dark green immature color to its lighter green color, and certainly before it ripens to its white, almost translucent color. Once picked, noni, like aloe, will denature extremely quickly due to its very active enzymes. After harvesting, it should swiftly be flash frozen. This is similar to what is done to fish caught at sea to keep them f esh. This stops it from losing its potency while not damaging any of its constituents. To process noni, freeze-drying is recommended. This removes only the water without damaging any of this miracle plant’s vital enzymes and other phytonutrients like xeronine and proxeronine. This pure high-quality noni fruit juice powder is then encapsu-has a very harsh taste and an extremely foul smell, similar to the fruit it self . Other methods of processing include thermal processing, dehydrat ion and air drying. Thermal processing is generally found in liquids, while the dehydrat ed noni is then milled and encapsulated. Unfortunately both methods utilize high heat (110+°F) , which can deactivate many of the vital compounds that make noni so import ant . Air-drying is effect ive without using damaging heat but has serious quality control problems for commercial production.
MODERN APPLICATIONS OF NONI
Noni possesses a wide variety of medicinal properties which originat e from its differing plant component s. The fruit and leaves of the shrub exert antibacterial activities. Its roots promote the expulsion of mucus and the shrinkage of swollen membranes making it an ideal therapeutic for nasal congest ion, lung infect ions, and hemorrhoids. Noni root compounds have also shown natural sedative properties as well as the ability to lower blood pressure.
Leaf extracts are able to inhibit excessive blood flow or to inhibit the formation of blood clots. Noni is particularly useful for its ability to treat painful joint conditions and to resolve skin inflammations. Many people drink noni fruit extracts in juice form for hypert ension, painful menstruation, arthritis, gastric ulcers, diabetes, and depression. Recent studies suggest that its anticancer activit y should also be considered. Concerning the therapeutic potential of the Hawaiin noni fruit, Dr. Heinicke writes: I have seen the compound found in noni work wonders. When I was still investigating its possibilities, I had a friend who was a medical research scientist administer the proxeronine to a woman who had been comatose for three months. Two hour safter receiving the compound, she sat up in bed and asked where she was. . . . Noni is probably the best source of proxeronine that we have today.19 Studies and surveys combined support the ability of noni to act as an immunost imulant, inhibit the growth of certain tumors, enhance and normalize cellular function and boost tissue regeneration. It is considered a powerful blood purifier and contributor to overall homeostasis.
xeronine, which appears to be able to regulate the shape and integrity of cert in proteins that individually contribute to specific cellular activities. Interestingly, this effect seems to occur after ingestion, inferring that the most active compound of noni may not be present in uneaten forms of the fruit or other plant parts. Some practitioners believe that xeronine is best obtained from a noni fruit juice precursor compound. The enzymatic reactions that occur with taking the juice on an empty stomach are what Dr. Heinicke believes set cellular repair intomotion.
A study conducted in 1994 cited the anticancer activity of Morinda citrifolia against lung cancer. A team of scientists from the University of Hawaii used live laboratory mice to test the medicinal properties of the fruit against Lewis lung carcinomas which were artificially transferred to lung tissue. The mice that were left untreated died in nine to twelve days. However, giving noni juice in consistent daily doses significantly prolonged their life span. Almost half of these mice lived for more than fifty days.20 Research conclusions state that the chemical constituents of the juice acted indirectly by enhancing the ability of the immune system to deal with the invading malig-nancy by boosting macrophage or lymphocyte activit y. Furt her evaluation theorizes that the unique chemical constituents of Morinda citrifolia initiate enhanced T-cell activity, a reaction that may explain noni’s ability to treat a variety of infectious diseases. 21
In Japan, similar studies on tropical plant extracts found that damnacanthol, a compound found in Morinda citrifolia, is able to inhibit the function of KRAS- NRK cells, which are considered precursors to certain types of malignancies.22 The experiment involved adding noni plant extract to RAS cells and incubating them for a number of days. Observation disclosed that noni was able to significantly inhibit RAS cellular function. Among 500 plant extracts, Morinda citrifolia was determined to contain the most effective compounds against RAS cells. Its damnacanthol content was clinically described in 1993 as “a new inhibit or of RAS function.” 2 3 The xeronine fact or is also involved in that xeronine helps to normalize the way malignant cells behave. While they are still technically cancer cells, they no longer function as cells with unchecked growth. In time, the body’s immune system may be able to eradicate these cells.
with arthritic disease. One link to arthritic pain may be the inability to properly or completely digest proteins which can then form crystal-like deposits in the joints. The ability of noni fruit to enhance protein digestion through enhanced enzymatic function may help to eliminate this particular phenomenon. In addition, the alkaloid compounds and plant met abolites of noni may be linked to its apparent anti-inflammatory action. Plant sterols can assist in inhibiting the inflammatory response which causes swelling and pain. In addition, the antioxidant effect of noni may help to decrease free radical damage in joint cells, which can exacerbate discomfort and degeneration.
The alkaloid and other chemical compounds found in noni have proven themselves to effectively control or kill over six types of infectious bacterial strains including: Escherichia coli, salmonellatyphi (and other types) , shigella paradysenteriae, and staphylo - coccus aureaus.25 In addition, damnacanthol, was able to inhibitt he early antigen stage of the Epstein- Barr virus.
The bioactive components of the whole plant, combined or in separate portions, have demonst rat - ed the ability to inhibit several different strains of bacteria. Anecdotal reports support this action in that noni seems particularly effective in shortening the duration of certain types of infection. This may explain why noni is commonly used to treat colds and flu. The chemical constituents found in noni and the possibility that they stimulate xeronine production— as well as initiate alkaloid therapy—may explain noni’s reputation for having immuno-stimulatory properties. Alkaloids have been able to boost phagocytosis which is the process in which certain white blood cells called macrophages attack and literally digest infectious organisms. Interestingly, the ant it umoraction of noni has been ascribed to an immune system response which involves stimulating T-cells. tropical regions during World War II learned of the fruit’s ability to boost endurance and stamina. Native cultures in Samoa, Tahiti, Raratonga and Australia used the fruit in cooked and raw forms. M. citrifolia is considered a tonic and is especially recommended for debilitated conditions.
The process of aging bombards the body with free radicals which can cause all kinds of degenerative diseases. The xeronine theory promoted by Dr. Heinicke submit s t hat as our bodies age, we lose our ability to synthesize xeronine. To make matters worse, the presence of many environment altoxins actually blocks the production of xeronine as well. He believes that the proxeronine content of Hawaiin noni fruit juice can help to block these actions, thereby working as an antiaging compound.26 The phytonutrients found in noni assist in promot - ing cell nourishment and prot ect ion from free radicals created by exposure to pollution and other potentially damaging agents. In addition, Morinda citrifolia contains selenium, which is considered one of the best antioxidant compounds available.
While scientific studies are lacking in this particular application of noni, Hawaiians used various parts of the plant and its fruit to treat blood sugar disorders. Anecdotal surveys have found t hat noni is current ly recommended for anyone with diabetes.
A 1990 study found that extracts derived from the Morinda citrifolia root have the ability to kill pain in animal experiments.27 Interest ingly, it was during this study that the natural sedative action of the root was also noted. This study involved a French team of scientists who noted a significant central analgesic activity in laboratory mice.28 Dr. Heinicke has stated, “Xeronine also acts as a pain reliever. A man wit h very advanced int est inal cancer was given three months to live. He began taking the proxeronine and lived for a whole year, pain-free.” 29
Skin Healing Agent
One of the most prevalent hist rical uses of noni was in poultice form for cuts, wounds, abrasions, burns and bruises. Using its fruit extract for very serious burns has resulted in some extraordinary healing. Because skin is comprised of protein, it immediately responds to the presence of xeronine.
burn site throught he direct application of a noni poultice is considered quite effective by Dr. Heinicke and his colleagues, who have studied enzymatic therapy. Concerning burns, he has written: I believe that each tissue has cells which contain proteins which have receptor sites for the absorption of xeronine. Certain of these proteins are the inert for ms of enzymes which require absorbed xeronine to become active. This xeronine, by converting the body’s procol- langenase system into a specific protease, quickly and safely removes the dead tissue from burns.30
The xeronine link to treat ing drug addiction is based on the notion that flooding t he brain with extra xeronine can reverse the neurochemical basis for addiction. This natural alkaloid is thought to normalize brain receptors which subsequent ly results in the cessation of physiological dependence on a certain chemical like nicotine.3 1 The potential of Hawaiin noni as a natural stimulat or for t he production of xeronine may have profound implications in treating various types of addictions.
Complementary Agents of Noni
PrimaryApplications of Noni
FEARING FATS: There's Plenty of Cause Overview
June 25, 2005 07:34 PM
FEARING FATS: There's Plenty of Cause Overview
A wealth of scientific evidence now exists which should have turned each and everyone of us into a fat “phobic.”1a-e In other words, virtually every health expert agrees that a high fat diet is directly linked to cardiovascular disease, various types of cancer and premature death. It’s no secret that excess dietary fat poses a tremendous health risk. The United States National Institutes of Health, the World Health Organization and many other scientific institutes have confirmed the frightening hazards of fat. Health proponents generally concur that excess fat can significantly shorten one’s lifespan. More than 10,000 medical papers are published every year dealing with obesity and cardiovascular disease, two of the most insidious killers of Americans. Western eating habits, which promote fatty, salty, sugary foods, have created massive widespread disease and tremendous suffering. Studies have shown that fat is the macronutrient associated with overeating -
TABLE 1. Total fat grams in single servings.4
and obesity.2 In spite of this finding we are eating more fat and becoming fatter. The average absolute fat intake has increased from 81 to 83 grams per day over the last ten years.3 Our obsession with fatty foods has exacted an enormous toll in the form of rampant obesity, clogged arteries, hypertension, heart attack, stroke, breast cancer, etc. Many of us remain oblivious to the fat gram count of foods we routinely pop into our mouths, unaware that one fast food entree may contain more fat grams than one should consume in one given day. Take a good look at the following list of foods which have been assessed for fat content. Fast food has become a 20th-century sensation which continues to boom and expand throughout our society. Many of us literally exist on fast food, which is frequently also “fat” food. It’s no wonder so many of us “battle the bulge”, and have skyrocketing cholesterol counts. Our love affair with greasy, fried, rich, creamy foods has burdened our bodies with the dilemma of excess fat “baggage,” resulting in phenomenal amounts of money being spent on weight loss programs. Worse still, thousands of Americans are dying before their time or living extremely compromised lives only because they ingest too much fat. Why is this? The bottom line is that fats taste good!5 Many of us were raised on seemingly innocuous foods that are loaded with fat. Some of these include:
macaroni and cheese battered fish sticks hot dogs cheese-filled casseroles pepperoni pizza burritos pancakes, waffles doughnuts pies and pastries ice cream candy bars ramen soup
Fat is also a major ingredient in most of the snack food we constantly nibble on, including chips, crackers, cookies, and nuts. Check ingredient labels to find the fat gram content of most snack foods. You’ll be surprised to find out just how fatty these foods are. Even a healthy sounding food like a “bran muffin” can contain 36 grams of fat! No wonder they stay so “moist”. In addition to the above foods, fat can add wonderful flavor to breads, vegetables and the like, and is usually used liberally in the form of butter, sour cream, whipping cream, melted cheese, cream cheese spreads, dips, cream sauces, and gravies. Fruits can also be high in fats. Did you know that one avocado has 30 grams of fat? One half cup of peanuts contains 35 grams of fat and only one glazed doughnut has 13 grams of fat. The majority of research points to fat as a much more dangerous culprit than anyone might have imagined. Saturated fats such as lard, palm, coconut oil, and beef tallow are particularly menacing. Research scientists have found over and over again that fats can contribute to the growth of tumors in animal studies.6 The National Research Council of the National Academy of Sciences reported that even a relatively small amount of extra body fat increases the risk of certain diseases for women and may compromise their longevity.7 Even being mildly overweight may be much more risky than anyone previously assumed.8
The Relat ionship between Breast Cancer, Fat s, Fiber And Indoles
Dr. Leonard Cohen, of the Dana Institute of the American Health Foundation at Naylor, believes that pre-cancerous lesions found in breast tissue will develop into cancer only if they are stimulated by certain agents such as fat.9 Women increase their risk of developing breast cancer when they consume a diet high in fat and animal protein and low in fiber, vegetables and fruits. When women put on weight, they have a tendency to create more estrogen since adipose tissue produces estrogen. Certain forms of estrogen, the so-called “bad estrogens” can act as carcinogens and are anything but desirable.10 High or unbalanced estrogen levels stimulate concerous tissue in the breast. Obesity is also associated with increased breast cancer mortality.11 The three most important ways to inhibit “bad” estrogen from inducing breast cancer are:
June 24, 2005 01:13 PM
Because 20th century medical practices have routinely over - prescribed antibiotics, the notion of a natural antibiotic with virtually no side-effects is intriguing to say the least. Echinacea is one of several herbs which possesses antibacterial, antiviral and antifungal properties. In a time when new life-threatening microbes are evolving and pose the threat of modern-day plagues, herbs such as echinacea are particularly valuable. More and more health practitioners are focusing on fortifying the immune system to fight off potential infections rather than just treating infection after it has developed.
Echinacea is enjoying a renaissance today. During the late 1980’s, echinacea re-emerged as a remarkable medicinal plant. In addition to its infection fighting properties, echinacea is known for its healing properties as well. As was the case with so many herbs, echinacea lost its prestige as a medicinal treatment with the advent of antibiotics. It has experienced a resurgence over the last two decades.
Echinacea has several other much more romantic names including Purple Coneflower, Black Sampson and Red Sunflower. It has also become the common name for a number of echinacea species like E. angustifolia, E. purpurea, and E. pallida. The genus derives its name from the Greek word echinos which refers to sea urchin. This particular association evolved from the prickly spiny scales of the seed head section of the flower. Historically, echinacea has sometimes become confused with Parthenium integrifolium.
The word echinacea is actually apart of the scientific latin term, echinacea angustifolia, which literally translated means a narrow - leafed sucker. The plant grows wild as a perennial exclusively in the midwestern plains states, but can be cultivated almost anywhere . Echinacea leaves are pale to dark green, coarse and pointy. Its florets are purple and its roots, black and long.
Echinacea has a strong Native American link in the Central Plains. Native Americans are credited with discovering the usefulness of this botanical without knowing its specific chemical properties. It was routinely used by Na t i ve Americans to treat toothaches, snakebite, fevers and old stubborn wounds.
Native Americans thought of echinacea as a versatile herb that not only helped to fight infection, but increased the appetite and s t rengthened the sexual organs as well. The juice of the plant was used to bathe burns and was sprinkled on hot coals during traditional “sweats” used for purification purposes. It is also believed that some Native Americans used echinacea juice to protect their hands, feet and mouths from the heat of hot coals and ceremonial fires.1 According to Melvin Gilmore, An American anthropologist who studied Native American medicine in the early part of this century, Echinacea was used as a remedy by Native Americans more than any other plant in the central plains area.
In time, early white settlers learned of its healing powers and used the plant as a home remedy for colds, influenza, tumors, syphillis, hemorrhoids and wounds. Dr. John King, in his medical journal of 1887 mentioned that echinacea had value as a blood purifier and alterative. It was used in various blood tonics and gained the reputation of being good for almost every conceivable malady. It has been called the king of blood purifiers due to its ability to improve lymphatic filtration and drainage. In time, echinacea became popular with 19th century Eclectics, who were followers of a botanic system founded by Dr. Wooster Beech in the 1830’s. They used it as an anesthetic, deodorant, and stimulant.
By 1898, echinacea had become one of the top natural treatments in America. During these years, echinacea was used to treat fevers, malignant carbuncles, ulcerations, pyorrhea, snake bites and dermatitis. In the early twentieth century, echinacea had gained a formidable reputation for treating a long list of infectious disease ranging from the commonplace to the exotic. The Lloyd Brothers Pharmaceutical House developed more sophisticated versions of the herb in order to meet escalating demands for echinacea.
Ironically, it was medical doctors who considered echinacea more valuable than eclectic practitioners. Several articles on echinacea appeared from time to time in various publications. Its attributes we re re v i ewed and, at times, its curative abilities ranged from the sublime to the ridiculous. In 1909, the Council on Pharmacy and Chemistry of the American Medical Association decided against recognizing echinacea as an official drug, claiming that it lacked scientific credibility. It was added to the National Formulary of the United States despite this type of negative reaction and remained on this list until 1950.
Over the past 50 years, echinacea has earned a formidable reputation achieving worldwide fame for its antiviral, antifungal and antibacterial actions. Consumer interest in echinacea has greatly increased, particularly in relation to its role in treating candida, chronic fatigue syndrome, AIDS and malignancies. Practitioners of natural medicine in Eu rope and America have long valued its attributes. In recent, years, German research has confirmed its ability to augment the human immune system. Extensive research on echinacea has occurred over the last twenty years. Test results have s h own that the herb has an antibiotic, cortisone-like activity.
Echinacea has the ability to boost cell membrane healing, protect collagen, and suppress tumor growth. Because of its immuno-enhancing activity, it has recently been used in AIDS therapy. Research has proven that echinacea may have p rofound value in stimulating immune function and may be particularly beneficial for colds and sore throats.3
PADMA BASIC: A Tibetan Herbal Formula
June 21, 2005 05:27 PM
By Isaac Eliaz, M.D.
"As an integrated system of health care, Tibetan medicine can offer allopathic medicine a different perspective on health. However, like other scientific systems, it must be understood in its own terms, as well as in the context of objective investigation. In practice it can also offer Western people another approach to achieving happiness through health and balance." --His Holiness the Dalai Lama, May 16, 1997
In this article I want to discuss a Tibetan-based herbal formula that reflects the philosophy outlined by H.H. the Dalai Lama. PADMA BASIC® is an extensively researched formulation that bridges the gap between Classical Tibetan Medicine and the modern Western medical paradigm. With over 50 published scientific papers spanning the last 30 years, PADMA's popularity among Western medical professionals can be attributed to its history of safe use and its health-enhancing properties. The original formula, used for centuries as a cardiovascular tonic and to counteract "heat" (inflammatory processes or infections), made its way to Europe by the first half of the 20th century. Acceptance of an ancient Tibetan formula into the Western medical tradition requires sensitivity to both the original Tibetan intention, and the rigorous requirements of the international pharmaceutical community. Today PADMA BASIC is produced in accordance with strict manufacturing guidelines. The herbs are grown organically, or meticulously tested to ensure they are not contaminated. Ingredients are verified using thin layer or high pressure liquid chromatography. While the highest "scientific Western methods" are used, traditional Tibetan "scientific methods" of smelling and tasting are also followed.
PADMA BASIC can be understood from two viewpoints. In Classical Tibetan Medicine, good health means maintaining a dynamic equilibrium of universal elemental forces. Illness is a manifestation of imbalance. Therapeutic intervention aims at restoring balance by treating the cause, not just the symptoms. Within this traditional model, PADMA has three functions:
Ingredients: Iceland moss (Cetraria islandica), Costus root, neem fruit (Azadirachtaindica), Cardamom fruit, Red Saunders heart wood (Pterocarpus santalinus), chebulic myrobalan fruit (Terminalia chebula), Allspice fruit, bael tree fruit (Aegle marmelos), Calcium Sulfate, Columbine aerial part (Aquilegia vulgaris), English Plantain aerial part, Licorice root, Knotweed aerial part (Polygonum aviculare), Golden cinquefoil aerial part (Potentilla aurea), Clove flower, Spiked ginger lily rhizome (Hedychium spicatum), Valerian root, Lettuce leaf (Lactuca sativa), Calendula flower, Natural Camphor (Cinnammum camphora).
Dr. Isaac Eliaz is a medical doctor and licensed acupuncturist with extensive training in complementary modalities. For 15 years, his practice has centered on the integrative treatment of cancer. He has been involved in numerous studies investigating the effects of nutritional supplements on cancer and has been granted two patents.
Scents of Balance
June 14, 2005 11:54 AM
Scents of Balance by Rosemary Sage Energy Times, January 5, 2005
Life can feel like an emotional rollercoaster, with the high-stress jitters following the low-mood blues. But aromatherapy-the healing power of scent-can restore equilibrium.
The use of volatile plant oils, including essential oils, for psychological and physical well-being dates back thousands of years. The ancient Chinese, Egyptians, Greeks and Romans used infused oils and herbal preparations for medicinal, fragrant, cosmetic, even spiritual reasons.
During the late 20th century, people started to relearn the benefits of aromatherapy and these days, aromatherapy's reputation as a soothing, healing art continues to grow. Once you've experienced the odiferous power of aromatherapy's essential oils, you'll keep coming back for more: These gently wafting odors have the power to stimulate or calm, invigorate or relax.
When you enter this scented world, "there you will find nature in one of its most powerful forms-aromatic liquid substances known as 'essential oils,'" says Valerie Ann Worwood in The Complete Book of Essential Oils and Aromatherapy (Thorsons). Essential oils form what Worwood refers to as the "fragrant pharmacy," a collection of concentrated substances used in pharmaceuticals, foods and cosmetics.
When you sniff the aromas of essential oils, "they enter and leave the body with great efficiency, leaving no toxins behind," Worwood points out. "The most effective way to use essential oils is...by external application or inhalation. The methods used include body oils, compresses, cosmetic lotions, baths-including sitz, hand and foot baths-hair rinses...perfumes...and a whole range of room [scenting] methods."
As Worwood explains, essential oils are produced in various parts of different plants. As a result, it takes a great deal of specialized work to extract essential oils. About 60,000 rose blossoms are consumed in the production of an ounce (!) of rose oil.
Just as the antioxidant phytonutrients we eat in vegetarian foods link our bodies to the health-promoting chemistry of plants, the penetrating nature of essential oils are thought to connect our souls to the essences of flora. "From inside comes the voice and from inside comes the scent," observed the 19th century German doctor Gustav Fechner, quoted by Robert Tisserand in The Art of Aromatherapy (Healing Arts Press). "Just as one can tell human beings in the dark from the tone of voice, so, in the dark, every flower can be recognized by its scent. Each carries the soul of its progenitor."
Fechner believed that the power of essential oils to stir our deepest emotions derives from their function as a vital means of communication in the plant world. As Tisserand asks, can't we imagine that flowers "communicate with each other by the very perfumes they exude, becoming aware of each other's presence?"
The Science Behind the Scent
While alternative medical practitioners have acknowledged the effectiveness of aromatherapy for thousands of years, only recently have conventional medical researchers begun seriously looking into how this technique works.
For instance, a study of estragole, a chemical found in basil, fennel and tarragon, determined that it could potentially ease back pain by inhibiting inflammation of the sciatic nerve. (The sciatic nerve, the longest nerve in the body, runs from the back down the leg.) The researchers discovered that estragole is "active on nerves," a conclusion that aromatherapy practitioners, who employ the scent of these oils to soothe pain, already knew. Science is verifying another piece of information long known to practitioners-that while certain essential oils can calm you down, others prod your alertness. In a study performed at the University of Northumbria in England, scientists found that sniffing the scent of lavender lulls the human brain into a comfortable, rather stupefied state, while rosemary, in contrast, can sharpen recall.
As the English researchers noted, lavender "produced a significant decrement in performance of working memory, and impaired reaction times for both memory and attention-based tasks." That's probably why the odor of lavender is noted for enhancing sleep. On the other hand, the scientists found that rosemary "produced a significant enhancement of performance for overall quality of memory and secondary memory factors." However, they did point out that under the influence of both of these oils, performance slowed when tackling a battery of memory tests. Apparently, the oils mellowed people so that they had little motivation to rush through the paperwork.
As Frazesca Watson notes in Aromatherapy Blends & Remedies (Thorsons): "The aroma of the oils directly affects our moods and emotions and sometimes our short- and long-term memory. Together with a wide range of physiological benefits, the aroma can help with emotional upsets such as depression, anxiety, nervous tension, anger, apathy, confusion, indecision, fear, grief, hypersensitivity, impatience, irritability, panic and hysteria."
Essential oils are especially helpful at defusing stress. Watson notes, "Treatments with essential oils are therefore very helpful for all sorts of stress-related problems, so common in our modern life."
As scientific research into the effects of these oils continue, conventional medical practitioners are sure to embrace them in increasing numbers. But before there were scientists around to confirm the effects of these wonderful scents, the ancient medical practitioners in Egypt and Greece attributed the origins of aromatherapy to the gods. For many people in today's overstressed world, the relaxing assurance of essential oils certainly seems heaven-s(c)ent.
Essential Fatty Acids - Lipids, Cell Memgranes & Eicosanoids
June 09, 2005 09:35 AM
Essential Fatty Acids and Phospholipids
Essential fatty acids & phospholipids are primary constituents of cell membranes, and as such they are vital to the makeup of the human body. Essential fatty acids are used to generate certain intra-cellular hormone-like substances, including prostaglandins and leukotrienes, which are responsible for regulating key bodily processes. Source Naturals essential fatty acid supplements are potent, effective and chemical-free.
LIPIDS, CELL MEMBRANES & EICOSANOIDS
Almost by definition, life is composed of cells, and cells are defined by membranes. One theory suggests that, around four billion years ago, self-replicating molecules, similar to the ribonucleic acid or RNA in our own cells, were synthesized from organic molecules. These self-replicating molecules adapted to changes in their environment to increase their potential for survival. Thus began the process of evolution that has led, over the eons, to us. One turning point was when these molecules developed membranes - envelopes which could help concentrate chemicals needed for the cell's survival. There existed in the "primordial soup" substances uniquely suited to this purpose: a class of organic compounds we call lipids . Lipids are more commonly called fats, and in this health and image-conscious age people often think of them as something to be avoided. However, the word fat refers to a variety of substances with a diverse range of chemical properties, which are essential for survival and well-being . The simplest lipids, fatty acids such as palmitic acid, consist of a hydrocarbon "tail" connected to a carboxyl group (COOH). The majority of lipids in food and in the human body occur in the form of triglycerides - a molecular configuration in which three fatty acid chains are attached to a 'backbone' of glycerol (an organic alcohol composed of a 3-carbon chain with an alcohol group attached to each carbon). The major roles of lipids can be described as energy and storage, structural, and metabolic.
Energy and Storage
Molecules can contain more or less chemical energy. In living systems most of the energy needed to drive chemical reactions is derived from oxidation. Oxygen, the ultimate electron acceptor, is a strong oxidant: it has a marked tendency to attract electrons, becoming reduced in the process. When a molecule undergoes a chemical reaction from a high-energy reduced state to a low-energy oxidized state, energy is released. This is what happens in a fire: the high-energy carbohydrates in wood, such as glucose, react with oxygen, releasing heat and the low-energy molecules of carbon dioxide and water. This is similar to what happens in metabolism.
Most of the carbon in a fatty acid chain is highly reduced, which makes fats more energy-rich than the other organic molecules that can be burned as food. This is what we mean when we say fats are high in calories - a measure of the amount of energy released when a substance is oxidized. Fats contain more than twice as many calories as carbohydrates. This makes fats an important storage fuel for most of the body.
Another important class of lipids in the human body consists of the phospholipids. Like triglycerides, phospholipids contain fatty acid chains- in this case two, one saturated and one unsaturated, attached to a glycerol backbone. Unlike triglycerides, in phospholipids the third carbon of the glycerol molecule is attached to a phosphate (a molecular group that contains phosphorus and oxygen), which is in turn attached to either an amino acid or, in the case of phosphatidyl choline, a molecule of the B-vitamin - like substance, choline.
Their unique molecular structure makes phospholipids amphipathic, which means 'likes both':
Fats, being hydrophobic, tend to separate out from water. When fat is mixed with phospholipids in the presence of water, the phospholipid molecules attach themselves to the molecules of fat and bring them into the water solution, enabling the fats to dissolve in water.
Phospholipids form a structure called a lipid bilayer, a two-ply sheet of phospholipid molecules in which the hydrophilic head groups face outward and are in contact with the water, and the hydrophobic tails face each other on the inside of the bilayer. This structure is one of the key constituents of the cell membranes that surround every living cell.
The lipid bilayer of cell membranes is a fluid in which membrane-embedded proteins "float." These proteins serve a wide variety of different functions. Some are enzymes, serving to carry out chemical reactions in the adjacent solution. Some are involved in signaling, in which a biochemical action in a cell is 'commanded' by means of a hormone or some such other signaling molecule. Still others are involved in transporting substances across the membrane, into or out of the cell.
The functions of membrane-embedded proteins are dependent on a very precise balance of phospholipids for their function. Phosphatidyl serine, for instance, has a negatively-charged head group that associates preferentially with a class of membrane-bound proteins called ATPases. ATPases regulate, among other things, the balance of sodium and potassium in intra- and extracellular fluids, a balance that is necessary for the integrity of our cells and also for the electrochemical impulses that make up our thoughts and feelings. Without phosphatidyl serine, these vitally important membrane-embedded proteins could not function.
Cholesterol is a waxy substance that is essential to the structure of cell membranes, which depend for their function on a delicate balance between fluidity and solidity. Cholesterol provides a semifluid matrix, as well as enhancing membrane fluidity. About 80% of the cholesterol the body uses is manufactured by the liver; the other 20% is consumed in food. Elevated blood cholesterol levels are associated with heart disease. Saturated fats are converted into cholesterol more readily than unsaturated fats, and polyunsaturated fats usually depress blood cholesterol concentration to some degree. Researchers have thus recommended that people lower their consumption of saturated fats and increase their consumption of polyunsaturated fats. A process called hydrogenation , in which hydrogen molecules are added, is used to harden these unsaturated fats to create solid spreads, such as margarine. This process causes formation of altered fats called trans fatty acids. Although the results are not conclusive, human and animal studies have pointed to possible deleterious effects from consumption of trans - fatty acids, which are estimated to account for 5.5% of all fats consumed by Americans. These studies include one in men and women that showed harmful effects of trans - fatty acids on blood cholesterol ratios.
When each link of a fatty acid chain contains an atom of hydrogen, as in palmitic acid, that fatty acid is said to be saturated . If two carbon links are double bonded to each other, each has one less hydrogen atom, and the fatty acid chain is said to be unsaturated. If a fatty acid contains one double bond, it is said to be monounsaturated, and if it has two or more double bonds it is said to be polyunsaturated . Certain polyunsaturated fatty acids cannot be manufactured by the body and must be obtained from the diet. These nutrients are called essential fatty acids and are necessary for the normal function of all tissues. The essential fatty acids fall into two categories:
In addition to being phospholipid precursors, essential fatty acids can be converted to a class of hormone like intracellular messengers called eicosanoids. The physiologic effects of eicosanoids are potent in minute quantities. Their effects are so powerful that they need to be produced near the site of their action and are quickly inactivated. The important eicosanoids include the thromboxanes, leukotrienes and prostaglandins (PGs ). Prostaglandin molecules consist of a five-carbon ring with two side chains. They can be distinguished from each other by numbers that refer to the number of double bonds in their molecular side chains: 1-series PGs have one double bond, 2-series have two double bonds, and so on. Prostaglandins mediate a variety of bodily processes, including inflammatory reactions, blood vessel contraction and dilation, and platelet aggregation. The different PGs have different effects on the body, and different essential fatty acids act as precursors for different PGs.
Important essential fatty acids in humans are the omega-6 fatty acids, which include linoleic acid (LA), gamma-linolenic acid (GLA), and arachidonic acid (AA). 1-series PGs are derived from GLA and tend to cause blood vessels to dilate and reduce the stickiness of platelets (cell fragments in the blood that help initiate blood clotting). 2-series PGs are derived from arachidonic acid and tend to increase platelet stickiness and cause blood vessels to constrict. Meat and dairy products are dietary sources of the PG2 precursor, arachidonic acid; American diets tend to be rich in these foods. The rate-limiting step for production of GLA in the human body is an enzyme called delta-6-desaturase (D6D). The action of this important enzyme can be blocked by a number of different lifestyle factors, including a diet high in saturated or trans- fatty acids and chronic alcohol consumption. A modest increase in consumption of GLA will significantly increase the ratio of GLA to AA in the tissues, which may have a beneficial effect on the homeostasis of the cardiovascular system. Supplementation with omega-3 fatty acids, such as flaxseed oil or fish oil, is beneficial for similar reasons. Omega-3 fatty acids are precursors for 3-series PGs, which reduce platelet stickiness. Series-3 PGs also tend to inhibit conversion of AA into its metabolites, the 2-series PGs.
The lipid composition of our diets has changed radically in the 20th century. Our intake of saturated fats has increased dramatically, and trans fatty acids, which did not exist before the advent of modern food processing technology, now form a major part of our diets. We eat less fish and green leafy vegetables, important sources of omega-3 fatty acids, than our ancestors did. Far from being an inert, homogeneous substance, fat is dynamic and varied - a subtle and interactive matrix for many of the biological processes taking place in our bodies, minute by minute.
Chem-Defense - Fight Chemical sensitivity ...
June 01, 2005 10:21 AM
CHEMICAL SENSITIVITY IS REAL.
COURTESY OF THE INDUSTRIAL REVOLUTION, OUR ENVIRONMENT HAS BECOME A STEW OF FOREIGN CHEMICALS. For some people suffering the malaise, lack of focus, and drained feeling associated with chemical sensitivities, home is the only sanctuary from this onslaught. For others, not even home is safe. We at Source Naturals take this threat very seriously. That’s why we created CHEM-DEFENSE.
Source Naturals’ CHEM-DEFENSE is a potent combination of Molybdenum, Glutathione, and Coenzymated B-2, nutrients which research has shown may help break down and dispel harmful chemicals from the body. And CHEM-DEFENSE is sublingual — it dissolves under the tongue so it goes directly into your bloodstream, where it can be delivered to your system, fast.
major problem has hit America in the late 20th century that is more far reaching than most people are aware — chemical sensitivity. In fact, some studies indicate that 1 out of 3 Americans may be afflicted with chemical sensitivities. In the past century, modern organic chemistry has synthesized and released into the world an estimated 300,000 xenobiotic (foreign to our normal biology) chemicals. The food processing and food growing industries put an approximate 10,000 xenobiotic chemicals into our food supply alone. These chemicals can be found in common items such as cleaning fluids, drycleaning compounds, glues, cigarette smoke, perfume, building materials and processed foods. Chemical sensitivity is the result of impairment or inadequacy of the body’s natural detoxification systems, allowing excessive levels of harmful, xenobiotic chemicals to accumulate in the body, and the results are often devastating. In sensitive people, artificial chemicals can cause an incredible range of problems: “fogginess” and lack of focus, emotional distress, fatigue, and more. The parts of the body that are most affected can vary from person to person. Some of the worst offenders are the aldehydes. The most infamous of these is formaldehyde (found in such widely used items as permanent press clothing, particle board, paints and upholsteries). The other common culprit is acetaldehyde (produced by Candida overgrowth or from alcohol consumption).
The Secret to CHEM-DEFENSE’S Power is Molybdenum
Fortunately, nature has provided the body with a special aldehyde detoxification pathway: an enzyme called aldehyde oxidase (ADO). ADO is activated by one of the coenzyme forms of Vitamin B2, Flavin Adenine Dinucleotide (FAD), and the trace mineral Molybdenum. Unfortunately, this enzymatic pathway can become impaired due to overexposure to foreign chemicals. In addition, aging, nutritional deficiencies, genetics and general poor health can greatly diminish the body’s production of these enzymes, causing a toxic buildup of aldehydes, leaving many individuals vulnerable. Current nutritional research has revealed that supplementing the diet with Molybdenum and Coenzyme B-2, both found in CHEM-DEFENSE, can increase levels of the important enzyme ADO, helping to dispel toxins from the body. A study published in the Townsend Letter for Doctors confirms the benefits of a sublingually administered 300 mcg dose (100 mcg three times a day) of Molybdenum. It was found that on the average, about 50-65% of the various symptoms of chemical sensitivity — including fogginess and other discomforts — were alleviated at least to some degree. Molybdenum is also important for several other enzymes, including xanthine oxidase, and most importantly, sulfite oxidase. Sulfite oxidase is responsible for breaking down sulfites, chemicals widely used as preservatives in wines, salad bars, produce, and other foods. Sulfites are a common culprit in chemical sensitivity reactions. In fact, by the 1980’s, it was conservatively estimated that 5,000,000 (five million) Americans were sensitive to sulfites and experienced discomfort upon ingestion. Sulfite oxidase is also important in the sulfation of various compounds, especially in the brain. This is particularly important, as the brain is often dramatically affected during bouts of chemical sensitivity. According to the Nutrition Desk Reference, the amount of Molybdenum required daily for people is 100 mcg to 500 mcg. It also states that the amount of Molybdenum in food can vary tremendously, depending on crop soil levels. Low levels are not at all uncommon, and they are lessened even further by commercial farming practices that utilize synthetic fertilizers which do not put Molybdenum back into the soil. The result? The typical American diet does not provide adequate Molybdenum. The form of Molybdenum included in CHEM-DEFENSE is Molybdenum Aspartate-Citrate, Molybdenum bound to the cellular metabolites Aspartic Acid and Citric Acid. This has been shown to be the most bioactive form available by experts in mineral metabolism.
Glutathione in its Most Bioavailable Form
Ultimately, the one organ that must cope with and attempt to relieve the body of toxic chemicals is the liver, often referred to by nutritionists as “the body’s most overburdened organ.” To accomplish this, the liver must rely heavily on Glutathione, a tripeptide (three amino acids bound together). The Glutathione in CHEM-DEFENSE will help the liver to produce adequate levels of the important enzymes glutathione peroxidase (GSHpx) and glutathione S-transferase (GSH-S), enzymes that are essential for breaking down and disposing of foreign chemicals in the body. Glutathione peroxidase (GSHpx) helps to break down hydrogen peroxide, a medium-level toxin which is found in many xenobiotic chemicals. GSHpx also prevents cell damage caused by fatty acid oxidation, which threatens the integrity of cell membranes. Glutathione is very fragile. In fact, when taken orally, it is often destroyed by protein-digesting enzymes in the stomach. As CHEM-DEFENSE is in sublingual form, it bypasses the digestive process and goes straight into the bloodstream, allowing for maximum activity.
Coenzyme B2 — The “Recycling” Nutrient
Once Glutathione is used in the body for its detoxification functions, it becomes oxidized Glutathione, meaning it has been “used up.” Fortunately, the human body can “recycle” oxidized Glutathione and return it to its beneficial reduced (active) state. This process is made possible by a coenzyme form of Vitamin B2 (FAD), which is present in CHEM-DEFENSE.
Sublingual Delivery for Maximum Benefit
Many nutrients, when taken orally, are never completely absorbed into the bloodstream, or not absorbed at all! Because this formula is in sublingual form, the nutrients in CHEM-DEFENSE are absorbed directly into the bloodstream through the blood vessels under the tongue and in the cheeks, assuring maximum bioavailability and benefit. In America today, as foreign chemicals continue to be released into the environment on an uncontrolled basis, people continue to experience chemical sensitivities for which there appears to be no solution. Now there is. Source Naturals CHEM-DEFENSE combines the most bioavailable forms of key antioxidant nutrients that are not only powerful in and of themselves, but work together synergistically to address the problems associated with chemical sensitivities. As with all of their other products, Source Naturals has taken special care to create a product that is all natural, hypo-allergenic, and sugarfree. CHEM-DEFENSE sublingual is available in two delicious flavors — natural peppermint, and for people on homeopathic regimens who prefer an alternative to peppermint, natural orange flavor. Let’s face it — life in the modern world is a battle for your health. Arm yourself with a powerful weapon: Source Naturals CHEM-DEFENSE.
May 12, 2005 09:33 AM
Keeping the Intestines Healthy"Friendly Bacteria" Therapy Breakthrough
by Richard Conant, L.Ac., C.N.
Ninety percent of the cells found in the human body are not of human origin.
No, this does not mean we are all products of some sinister alien experiment.
The human body is made up of about 10 trillion cells. This huge number is dwarfed by the bacteria we all carry around in our intestinal tracts. The lower bowel is a campground for roughly 100 trillion bacteria, single-celled plant organisms that can be seen only through a microscope.
When we enjoy good intestinal health, the bulk of these bacteria are beneficial. Known as "friendly flora," these tiny guests help digest our food by breaking down undigested proteins, fats and carbohydrates. The friendliest of the friendly bacteria are the "lactobacilli," so named because they produce lactic acid in the bowel, by fermenting carbohydrates. This lactic acid production is profoundly important for keep the intestines healthy. And good intestinal health is the foundation of overall health.
How do we maintain a thriving population of lactic acid-producing bacteria in the gut? First introduced into the human body through mother's milk, lactobacilli are somewhat fragile. Stress, poor diets, and antibiotics can kill them off. They should be replanted fairly regularly throughout life. One way to do this is through consumption of cultured milk products such as sour milk, kefir and yogurt, which contain live lactobacilli. They can also be consumed in dietary supplements, but this may or may not be a reliable route. Bacterial products do not keep very well on the shelf, they require refrigeration, and are largely destroyed on the trip from the mouth to the gut by our own digestive juices.
Introducing Lactobacillus sporogenes- a revolutionary new friendly bacteria supplement.
This article will focus on one particular species of lactobacilli, a relatively unknown member of the family called Lactobacillus sporogenes. This lactic-acid producing bacteria may prove to be one of the most practical forms for use in supplements, thanks to a unique property not shared by the more well-known friendly flora such as acidophillus. L. Sporogenes is a spore-forming bacteria. Safely enclosed within a spore coat that protects it from the environment, L. sporogenes is resistant to heat, oxygen and digestive acids. Once L. sporogenes reaches the intestines, its spore coat dissolves, freeing the bacteria to multiply and churn out the beneficial lactic acid. (The spore coat, made up of a calcium-protein-carbohydrate complex, is harmless).1
The difficulty of keeping friendly bacteria supplements alive is an ongoing problem for manufacturers of these products. Studies have analyzed various commerical products claiming to contain acidophilus and found they often contain few live bacteria.2,3 L. Sporogenes is naturally microencapsulated; this insulates it from the gauntlet through which friendly bacteria in dietary supplements must pass.1 Autointoxication-Poisoning by Bacterial Toxins The intestinal tract may also play host to pathogenic, or disease-causing bacteria. These "unfriendly flora" cause putrefaction and release injurious toxins into the lower bowel. This healthy picture is all too common, and has long been concern of wholistic health practitioners.
The concept of "autointoxication," poisoning of the body by intestinal toxins, was popular among doctors in the late 19th and early 20th centuries. An editorial on the dangers of autointoxication which appeared in the June 3, 1893 issue of the Journal of the American Medical Association (JAMA) declared that "most likely a large majority of chronic diseases take their origin from this cause."4 The famous Russian physician Eli Metchnikoff pioneered the use of lactobacteria for preventing autointoxication and restoring bowel health. His landmark work 'Prolongation of Life' sparked interest in lactobacilli as a food supplement.5,6
Naturopathy, widely practiced during the early twentieth century, has always stressed the fundamental importance of bowel cleansing. With the advent of so-called "scientific medicine," naturopathy slipped into decline, and the concept of autointoxication was discredited. Over the last thirty years or so, this has changed. Naturopathic medicine has rebounded, and the importance of bowel health is once again recognized. A paper published in the New England Journal of Medicine in 1964, while opining that autointoxication "was exploited by quacks and faddists" in the early 1900's concedes that "the concept of autointoxication must now receive serious consideration."7
Leaders in the rebirth of natural medicine such as Dr. Bernard Jensen have helped educate the public about the importance of keeping the bowels healthy through regular use of lactobacilli. Jensen is well-known for his extensive studies of regions such as the Hunza Valley in Pakistan where people commonly live well over one hundred years. Jensen and others have noted that the consumption of fermented dairy products containing lactobacilli is a common dietary practice in these areas. Their observations have contributed to the popularity of friendly bacteria supplements. At the same time, clinical research has provided ample evidence of the beneficial effects of lactobacteria supplementation.5,9<.sup>
Eubiosis-Keeping a Healthy Bacteria Population in the Intestinal Tract
In his book 'Tissue Cleansing Through Bowel Management, which contains a wealth of valuable wisdom on intestinal health, Dr. Jensen writes, "Where health and vitality are found, we invariably find the friendly and beneficial microbes ... To a large extent the flora in the bowel determines the state of health in an individual."8 In a healthy bowel the friendly flora make up the bulk of the bacteria population. The unfriendly, disease-causing organisms are in the minority. The good bacteria keep them firmly under control. This healthy microbial balance in the gut is called "eubiosis."
Life in our modern industrial society is hardly favorable to eubiosis. Residents of the Hunza Valley lead unhurried lives in a pristine, pollution-free environment. They grow their own food in fertile, nutrient-rich soil, work close to the landÐand consume lactic-acid producing bacteria on a daily basis. For the rest of us who cannot hope to enjoy this enviable lifestyle, eubiosis is something we should never take for granted. This means taking proactive steps to plant the seeds of health in our intestinal garden, by using a viable friendly bacteria supplement.
Supplements which help to populate the intestinal tract with friendly bacteria are known as "probiotics." The term "probiotic" literally means "for life.' (In contrast, "antibiotic" means "against life.") Probiotics restore the natural state of "eubiosis" that is so very important for health and longevity.
L. Sporogenes-an ideal probiotic
Not every species of lactobacilli qualifies as an effective probiotic. As noted above, many do not survive processing, storage and passage through the digestive system very well. The following attributes make L. Sporogenes an ideal probiotic supplement:1,10,11
1) Naturally microencapsulatedÐstable at room temperature and can be stored unrefrigerated for long periods without loss of viable organisms.
2) Tolerates heat, stomach acid and bile, allowing it to successfully travel into the lower bowel.
3) Non-pathogenic, has only beneficial effects on its host. Has similar characteristics as acidophilus: prefers a mild acid environment; produces lactic acid, digestive enzymes, etc.
4) Readily multiplies in the human gut. In the stomach, the spore coat absorbs moisture and begins to swell. Upon reaching the small intestine, the bacteria cells germinate and begin to multiply, doubling in number every 30 minutes.
5) Produces enzymes which help digest protein, fats and carbohydrates. These enzymes include lactose, the enzyme that digests milk sugar.12
6) Creates a favorable environment (mildly acidic) in the gut for other friendly bacteria to thrive. Prevents overgrowth of pathogenic organisms.
7) Produces lactic acid in the form of L- lactic acid only.
The last point is especially important. Lactic acid occurs in the form of three isomers (substances with identical molecular structures that have different shapes): L-lactic acid, D-lactic acid and DL-lactic acid. The D form is metabolized slowly, and can produce acidosis in the system. (Infants have a particularly difficult time metabolizing D-lactic acid.)11,13 DL-Lactic acid, the kind acidophilus makes, may be converted to either D or L.
The L form is the one we want. L. sporogenes is a "homofermenter," it makes L-lactic acid exclusively. Lactic acid keeps the gut mildly acidic. This acidity is essential for the gut to be a hospitable home for friendly bacteria, and stops the growth of the unwelcome disease-causing bacteria.
L. sporogenes has only one drawback. It is a transient visitor that does not permanently colonize in the digestive tract. A study on the retention of L. sporogenes found no bacteria in the feces six days after consumption was discontinued.14
L. Sporogenes-Results from Clinical Studies
L. Sporogenes is used extensively in Japan and approved by the Japanese equivalent of the FDA. L. sporogenes has been given to hospital patients suffering from intestinal complaints such as gas and bloating due to abnormal fermentation, constipation, diarrhea and indigestion. (These problems often occur after surgery or chemotherapy.) A total of 16 clinical reports are on record in Japanese hospitals, documenting 293 case of digestive complaints treated with L. sporogenes.15 The overall improvement rate is an impressive 86 percent. Results are typically seen within four to five days. L. sporogenes has also been used with success to clear up diarrhea in newborns.16 Like other lactobacilli, L. sporogenes lowers blood cholesterol. (Lactobacilli break down cholesterol and bile salts in the intestinal tract.) Researchers at a hospital in New Delhi, India gave L. sporogenes tablets to 20 patients with high cholesterol for twelve weeks.17 Total cholesterol levels were substantially reduced, along with LDL cholesterol, and the beneficial HDL rose slightly.
The popularity of L. sporogenes in other countries as an ideal friendly bacteria supplement will no doubt be soon matched in the U.S. This microscopic helper for intestinal health is now sold in probiotic products under the name "Lactospore®."
1. Gandhi, A.B., Nagarathnam, T. Probiotics in veterinary use. Poultry Guide 1990;27(3):43-47.
2. Brennan, M., Wanismail, B., Ray, B. Prevalence of viable Lactobacillus acidophilus in dried commercial products. Journal of Food Protection 1983;46(10):887-92.
3. Gilliland, S.E., Speck, M.L. Enumeration and identity of lactobacilli in dietary products. Journal of Food Protection 1977;40(11):760-62.
4. Dalton, R.H. The limit of human Life, and how to live long. JAMA 1893;20:599-600.
5. Shahani, K.M., Ayebo, A.D. Role of dietary lactobacilli in gastrointestinal microecology. American Journal of Clinical Nutrition 1980;33:2448-57.
6. Metchnikoff, E.. Prolongation of Life. New York: G.P. Putnam Sons;1908.
7. Donaldson, R.M. Normal Bacterial populations of the intestine and their relation to intestinal function. New Eng. J. Med. 1964;270(18):938-45.
8. Jensen, B. Tissue Cleansing Through Bowel Management. Escondido, CA: publ. by Bernard Jensen, D.C.;1980.
9. Schauss, A.G. Lactobacillus acidophilus: method of action, clinical application, and toxicity data. Journal of Advancement in Medicine 1990;3(3):163-78.
10. 'General InformationÐLactospore®' 1996; Sabinsa Corporation: Piscataway, NJ.
11. Gandhi, A.B. Lactobacillus sporogenes, An Advancement in Lactobacillus Therapy. The Eastern Pharmacist August 1998:41-44.
12. Kim, Y.M., Lee, J.C., Choi, Y.J., Yang, H.C. Studies on the production of beta galactosidase by lactobacillus sporogenes. Properties and application of beta galactosidase. Korean J. Appl. Microbiol. Bioeng. 1985;13(4):355-60.
13. Oh, MS. D-Lactic acidosis in a man with short bowel syndrome. New Eng J Med 1979;31(5):249-52.
14. Hashimo, K. et. al. New Drugs and Clinics 1964;13(9):53-66.
15. 'Abstracts of papers on the clinical studies of Lacbon' Unpublished data.
16. Dhongade, R.K., Anjaneyule, R. Lactobacillus sporogenes (Sporlac) in neonatal diarrhea. Unpublished data.
17. Mohan, J.C., Arora, R., Khaliullah, M. Preliminary observations on effect of Lactobacillus sporogenes on serum lipid levels in hypercholesterolemic patients. Indian J. Med. Res. 1990;92(B):431-32.
VitaNet ® Staff