Search Term: " Citrate "
Has your doctor told you about these natural ways to eliminatekidney stones?
December 20, 2018 08:50 AM
Kidney stones are both very painful, and frightfully common. One in ten people will experience a kidney stone in their life. There are some natural remedies that can help dissolve kidney stones once they form. One option is pomegranate juice, and a different option is dandelion root. Basil is also known for being good for kidney health. Lemon juice is full of citrate that may help break down kidney stones making them easier to pass.
"Citrate found in lemon breaks down kidney stones into smaller pieces so that they can pass more easily. Moreover, this substance also prevents the formation of calcium stones."
Read more: https://www.naturalnews.com/2018-12-15-natural-ways-to-eliminate-kidney-stones.html
Have you tried the new eco-friendly Health Ranger Dishwasher Detergent?
April 02, 2017 03:44 PM
Most dish washing detergent contains chemicals that are potentially hazardous to humans. New eco-friendly dish washer detergent are safe and actually work better than normal dish washer detergent. A single box of the detergent has more than conventional commercial brands found in most stores. Health Ranger Eco-Friendly Dishwasher Detergent is cheaper than the more dangerous non green product. Most dishwasher detergent contain 1,4-dioxane a contaminate that doesn't have to be listed. The worst detergents have many parts per million of 1,4-dioxane inside.
"There’s a new product line at the Health Ranger Store, and it’s carefully formulated to protect the environment:"
Read more: http://www.naturalnews.com/2017-03-25-have-you-tried-the-new-eco-friendly-health-ranger-dishwasher-detergent.html
Relieve the Holiday Stress with Magnesium
The holiday season is meant for having quality time with friends and family, going on an adventure, taking time off work and so on. However, it can also be very stressful given the many guests to entertain, tight budget to stick to, preparing family meals, the shopping craze and so much more. It is important to gain control in this period of the year since too much stress can lead to depression alongside other physical and psychological issues. Fortunately, we have magnesium, the original chill pill, to get you back into the holiday cheer.
Magnesium is an essential mineral that plays a huge role in cell functioning and relaxation. It has been used in hospitals to treat a myriad of complications including anxiety, irritability, muscle cramps and headaches. Magnesium accounts for over 250 enzyme reactions in our bodies and regulates the secretion of stress hormones. It is basically the fuel that your body runs on and hence its deficiency will lead to undesirable symptoms like brain fog, anxiety, aggression and fatigue among others. Modern farming and lifestyle changes have led to rather low levels of magnesium in our bodies as compared to decades ago. Magnesium will particularly be used up in greater quantities by your body during periods of extreme stress like this holiday season. This will usually translate in poor stress management, thus the more reason you should take some magnesium.
Some of the magnesium-rich foods include parsley, avocado, bananas, kelp, leafy greens like spinach, soy beans, brown rice, cashews and almond. In addition to providing this crucial mineral these foods also pack other nutritional benefits. Alternatively, you can also take a magnesium supplement like magnesium Citrate and magnesium oxide to help rid some of that holiday stress. Lastly, taking baths in Epsom salts (magnesium sulfate) is also a great stress reliever plus it works wonders in treating colds, detoxifying the body, relieving back pain and sore muscles.
Does Garcinia Help With Weight Loss?
Garcinia cambogia, a tropical fruit obtained from a herb called Malabar tamarind, has for a long time been used as a weight loss supplement. Garcinia cambogia is found to grow naturally in South East Asia and some parts of Indonesia. Traditionally, this herb was used as food flavor by traditional communities in India. The fact that this supplement is obtained naturally implies that it has minimal side effects when used for weight loss by an individual.
How does Garcinia cambogia works?
The critical component that gives Garcinia cambogia its weight loss property is called hydroxycitric acid or simply HCA. Garcinia cambogia works through;
What determines the success of Garcinia cambogia in any weight loss program is the concentration of HCA. The recommended HCA concentration that you should buy is 60%. Moreover, it is also imperative to consider shopping for the Garcinia cambogia products that are certified and approved by the Food and Drug Administration. This is to ensure that what you are shopping is safe and suitable for all your individual weight loss needs.
Does The Red Raspberry Have Healing Properties?
March 26, 2014 11:54 AM
Red raspberry fruit
Raspberry provides some of the very best results when it comes to the medicinal values especially in herbal medicine. The usefulness of the plant delivered from roots, bark, leaves and the fruit. Due to the wide range of minerals that found in red raspberry, which includes vitamins, potassium, calcium, sulphites and phosphate. The leaves contain important acids like citric, malic, tartaric and Citrate, which are very good for the body. Red raspberry used in many cases to treat and prevent certain digestive system related diseases like diarrhea and dysentery.
Health benefits of raspberry
In many cases, raspberry in form of vinegar is used to cure sore throats and different cough related complications. The flowers of red raspberry used for the treatment of pimples in adolescents as well as poultice for eye inflammation. The juice made from red raspberry used as laxatives or as a remedy for children with fever, as well as the treatment of cystitis.
Raspberry products are used worldwide by women who are pregnant or have menstrual complications. The underlying factor in this case is that raspberry used to stop or reduce mucous discharge from genitals hence reducing the pain experienced during menstruation. For pregnant women red raspberry products used to prevent postpartum depression and hypertension while boosting breast milk production during lactation. In other cases, the leaves of red raspberry used to promote fertility in both men and women and prevent the causes of miscarriages.
Raspberries mixed with other products to produce medicines that can cure diseases like malaria, gonorrheal, leukemia and other dangerous diseases. This achieved through the ability of raspberry fruits having constituents that act like anti-septic, anti-gonorrhea, anti-malaria and anti-leucorrhea.
Lavilin Deodorant reviews.
March 04, 2014 09:03 AM
There are many deodorants in the market but Lavilin is among the reputed deodorants. It is a gentle and effective deodorant.
Aluminium-some deodorants contains aluminium which causes breast cancer and Alzheimer. Most of the ingredients are from natural sources. This makes Lavilin a premier deodorants.
It is also free from Parabens, though most anti-perspirants uses Parabens to improve shelf life, Lavilin uses natural methods. Parabens are very dangerous to our bodies since they can damage central nervous system, cause birth defects and endocrine disruption.
It contains zero Propylene Glycol, Triclosan and Phthalates which are also very harmful to your health.
It is also free from alcohol which damages skin pores and also causes blisters. Deodorants which contains alcohol will cause blisters and users will get irritation when they take bath.
How it works.
It works by eliminating bacteria that causes odor smell in your armpits. It does not prevent you from sweating, sweating is a very health process and any product that hinders normal body processes is definitely not good at all.
Lavilin uses essential oils to eliminate bacteria and ensure your skin remains fresh and you have a good smell.
Direction of use.
This product should be used after taking shower. It has a good smell which will not work well if you have not taken bath.
You can also use it after shaving, it does not cause irritations, it is very friendly.
Upon it use, you will have fresh breath for more than 72 hours. It has a good smell and it will keep your skin fresh for more than 72 hours. It does not wear off easily even after taking a bath, it is promising product that will keep you confident for more than 4 days.
It is long lasting, upon wearing it, it will remain effective for more than 72 hours. You don’t need to use it daily.
It is not affected by water, the scent will remain after taking bath.
There is no strong smell, it scent is just friendly to you and other people. It is never shouty and only a person close to you will smell the scent.
It does not stain clothes or make your armpits white. You clothes will not be discolored by use of Lavilin nor will your armpit get white color.
You can use it after shaving, it does not cause blisters or irritations. It is very friendly.
It is also very use, it has few and easy few to follow instructions.
Lavilin does not seem to be effective to men. It can last for more than 4 days when worn by a lady but for a man it will last for only three days. This call for regular use.
Lavilin can be used by body builders or people taking strenuous exercise. It can also be used in nay weather, sunny, rainy or high humidity, it effectiveness is not lessened by weather condition.
Calcium and magnesium - vital to health
December 20, 2012 02:06 PM
Calcium and magnesium are two essential minerals for the body, bringing serious damage if there is a deficiency. Calcium is essential for maintaining bone strength in the body, but also for the functioning of nerve and muscle cells.
Bones perform several roles in the body, but most of us are interested in the preservation of acid-base balance (pH). When the pH of the blood is too acidic , bone alkaline elements released (alkali salts) to neutralize acids. This leads to loss of bone mass (and calcium), while rapidly releasing toxins and heavy metals stored in bone if there are metals and toxins present.
Most of us know that calcium is found in dairy products. True, but the information is not complete. You should know that of all dairy products, yogurt offers the most calcium, about 200 mg in a cup. But if you want the most bioavailable calcium, ie one that is most easily absorbed and can be used fully by the body, then you need to take calcium Citrate.
If the food based calcium intake is not optimal and extremely diverse, then you need calcium-based vitamin supplement products. Calcium supplements may be consumed with meals for maximum digestion and absorption. But even if you take dietary supplements, diet should not remain poor, continue to get adequate amounts of calcium from food sources.
Magnesium has an important role in the efficient functioning of the nervous system, muscular system and enzyme processes in the body. It is necessary for calcium absorption. The ratio of the two minerals is especially important. An adult daily needs for bone health by around 1,500 mg of calcium and 1000 mg of magnesium. Bones are living tissues that rebuild constantly. A healthy diet, exercise, enough sleep (at least 8 hours) and keeping well hydrated with water helps strengthen bones. Calcium and magnesium, combined doubles benefits to our body, especially if they are of Citrate in origin.
Cal-Mag Citrate Why?
Studies have shown that calcium and magnesium Citrate is the easiest form to digest with minimal stomach acids. This make it work great for older individuals who have low stomach acids or who are on proton pump inhibitors.
What Form Of Calcium Is The Best Calcium?
February 21, 2012 11:21 PM
Manypeople these days want to know which form of calcium is the best form of calcium. Calcium happens to be an essential nutrient for the body. However, since this nutrient serves a variety of purposes, therefore, it can be a bit tricky to determine which form is the best. There, in fact, might not be a single best form of calcium but probably quite a few, depending on what the calcium is needed for.
Calcium Complex (MCHA) Microcrystalline Hydroxyapatite
Everyone is aware that calcium is the building block of bones and for the treatment of a bone-related condition like osteoporosis; Calcium Complex (MCHA) Microcrystalline Hydroxyapatite is the best calcium. Supplements containing this form of calcium have, in fact, been proven to be effective at increasing bone density and reversing osteoporosis. Among the biological forms of calcium available, what makes MCHA one of the best forms of calcium for treating osteoporosis and increasing bone density is because it is excellent absorbed by the body. Calcium carbonate is often recommended by medical doctors because a very minimal amount of pills need to be taken.
For those who do not want to use a form of calcium derived from a biological, animal source and are, in fact, in search of the best calcium for the maintenance of bones, then Calcium Carbonate is perfect. This form of calcium is the second best in regards to absorption by the body. Calcium Carbonate is often recommended by medical doctors because a very minimal amount of pills need to be taken. Calcium Carbonate supplements can be found quite easily and they are mostly affordably priced.
Supplementing calcium also becomes necessary for anyone who has recently undergone Bariatric surgery. While Calcium Carbonate can also be used in such a situation, however, the best calcium in this case would be Chelated Calcium. Chelated Calcium is a form of calcium that is used in combination with beneficial amino acids. In comparison to Calcium Carbonate, research has shown that Chelated Calcium is a far more biologically available form of calcium. However, the dosages of this calcium that need to be taken are generally quite large. Above all, Chelated Calcium supplements can be quite costly too.
Calcium Citrate is an ideal alternative to Chelated Calcium, in fact, it is another form of Chelated Calcium, but the supplements that contain this form of calcium are usually more inexpensive. Not only this, those who choose to use this form of calcium will also get to take lower dosages. Calcium Citrate is a form of calcium that is acid based and is quite capable at supplementing the body with calcium since it is quite effectively absorbed. Since no additional stomach acid is required for the absorption of this form of calcium, therefore, Calcium Citrate at just about any time.
There are many other forms of calcium that are quite ideal for the body as well and can prove to be beneficial as well. This is the reason that those in search of the best calcium will come across numerous choices and some of the best ones were mentioned here.
Using Strontium as a Supplement For Bone Health
June 02, 2011 03:10 PM
Strontium is an essential ingredient in the formation of bone. It is not an element that many are familiar with, although Strontium 90 was a 1977 British band that first brought together Sting, Stewart Copeland and Andy Summers before they formed Police. That information, however, will not help your arthritis or osteoporosis. What will help is a supplement of strontium.
This element is an essential component of bone, even though it is present in very small quantities. What it does is to catalyze the fusion of calcium that forms bone structure, and if your bones are weak a supplement of strontium should generate fresh bone from the calcium in your diet and help reduce the potential for your limbs to fracture.
Along with strontium, you should take foods or supplements containing calcium, potassium magnesium and vitamin D. All of these are involved in building strong bones, although strontium is often the one that is missed.
The Krebs Cycle - Our Lifes Blood!
January 13, 2011 05:00 PM
The Krebs Cycle, also known as the Citric Acid Cycle, is an important series of biochemical reactions that are intrinsic to cellular respiration and the generation of energy from oxygen and glucose in aerobic organisms. Although humans can generate energy anaerobically, they cannot do so for long periods and oxygen is essential for life because it fuels the Krebs Cycle. Without this cycle, there would be no available energy to maintain our vital processes.
What is The Krebs Cycle
We shall first discuss exactly what the Krebs Cycle is and then its importance in the body. The process takes place within the mitochondria of the body cells.
A. The cycle begins with the ten-step pathway of glycolysis, during which glucose is converted to two molecules of pyruvate: no oxygen is required for this step. Basically:
Glucose + 2NAD+ + 2P + 2ADP = 2Pyruvate + 2NADH + 2H+ + 2ATP
The pyruvate can then undergo aerobic or anaerobic respiration to generate energy. The Krebs Cycle is the aerobic route, and significantly more efficient that the alternative fermentation.
B. The two pyruvate molecules are then oxidized to two of Acetyl CoA with the release of carbon dioxide. The two acetyl groups of the Acetyl CoA are donated to Oxaloacetate in the presence of water to form Citrate.
C. Citrate then undergoes a number of chemical reactions to arrive back at Oxaloacetate again and the cycle starts all over again by reacting with more Acetyl CoA from Pyruvate and oxygen to form Citrate again. During the cycle more ATP is produced and electrons and other species are sent into the Electron Transfer Chain where most energy is generated.
During this cycle three major events occur:
1. During the various transformations of Citrate, specifically when Succinyl-CoA is converted to Succinate, one Guanosine Triphosphate group (GTP) is generated, which then donates a phosphate to Adenosine Diphosphate (ADP) to create the energy molecule Adenosine Triphosphate (ATP).
2. Over the whole cycle, three molecules of Nicotinamide Adenine Dinucleotide (NAD) are reduced to NADH that donates its electrons to the electron transport chain that is responsible for the generation of large quantities of ATP.
3. A molecule of Flavine Adenosine Dinucleotide (FAD) is reduced to FADH2, again donating its electrons to the electron transport system and the generation of energy.
Factor 2 and 3 are of more significance to energy generation than factor 1, and are the major means by which the Krebs Cycle generates energy.
Electron Transport Chain
The Krebs Cycle takes place within the mitochondria, structures that are contained in each of your body cells. Also within these mitochondria are a series of membranes that are very important in the generation of energy.
The major energy produced in your body cells comes from the Electron Transport Chain, a series of chemical reactions between an electron donor and an electron acceptor. Such reactions drive the transport of hydrogen ions (H+) across the membranes in the mitochondria.
The electron donors are species such as NADH, FADH2 and succinate and the electron acceptors are oxygen molecules. Hence the importance of oxygen in the process of aerobic respiration. The H+ ions are driven across the membranes and result in the conversion of ADP to ATP energy. In essence, the hydrogen atoms and electrons take part in a progressive chain of redox reactions, and at the end react with oxygen molecules and change it to water.
The Ultimate Products
Ultimately, through the whole chain and cycles of:
Glucose to pyruvate (glycolysis) Pyruvate to Acetyl CoA + CO2 (oxidation) Acetyl CoA to Citrate and the entire Krebs Cycle (reduction and oxidation) Krebs Cycle products to the Electron Transfer Chain Electron Transfer Chain to Water and ATP (redox) Final oxidation of hydrogen atoms to water
Basically: Glucose + Oxygen + 30ADP = Carbon Dioxide + Water + 30ATP
This is not balanced of course, and the ATP could be anything from 29 to 38, though 29.85 is the most accurate calculation to date. The entire process of glycolysis, oxidation, Krebs Cycle and Electron Transport Chain is powered by a series of enzymes and a small amount of ATP energy.
Glucose and oxygen are used up as the raw materials and ATP energy molecules are the product. It has been calculated that the total ATP yield obtained from one molecule of glucose lies between 29.5 and 30 molecules of ATP.
The Importance of the Krebs Cycle to Your Body
Were it not for the Krebs Cycle you would not be able to generate energy efficiently from your food. In particular, the carbohydrate content of your food. Carbohydrates are available in your diet from two sources: simple and complex carbohydrate foodstuffs such as cereals and grains, and fats and oils from animal and vegetable sources. They are also available from proteins, which are composed of amino acids at the head of the molecule with a carbohydrate tail.
Carbohydrates by definition contain only carbon, hydrogen and oxygen molecules, and can be converted to glucose within your body. Proteins can be deaminated and then the carbohydrate portion again converted to glucose. In fact, your body will initially use the carbohydrates in your diet as a source of glucose for its glycolysis to pyruvate, then the fatty tissue in your body, then the proteins will be deaminated so your body can get to the carbohydrate they contain.
Were it not for the Krebs Cycle, your body could not use the glucose as described above to generate energy. The only option open to it would be anaerobic respiration, or energy production in the absence of oxygen. ATP is still generated, but much less efficiently.
Anaerobic respiration is basically respiration without oxygen. If there was no Krebs Cycle, then this is the only way your body would have to create energy.
Because no oxygen is actually needed for glycolysis or the Krebs Cycle, anaerobic respiration can proceed right to the end of the Electron Transport Chain. Then instead of oxygen being used as the terminal electron donor, it has to be another species such as nitrate or sulfate. Because the Reduction Potential of these species is much lower than that of oxygen, the amount of ATP energy produced is also much lower.
Your body tries to compensate by producing even more pyruvate and the excess is removed through lactic acid fermentation. Although this also generates ATP energy enough for short-term use, it leads ultimately to lactic acidosis and a reduction in pH, causing pain and vomiting.
Ultimately, if oxygen is not forthcoming, the brain runs short of the energy needed for it to work and you die. There is insufficient ATP generated from anaerobic respiration to maintain human life.
The Krebs Cycle is of critical importance for the production of energy: not just the energy to enable you to run fast, but to enable your metabolic processes to continue. It is needed for both aerobic and anaerobic respiration, and while lactic acid fermentation can be used by your muscle cells as a brief but effective means of generating short-term energy, it is insufficient to maintain the needs of your metabolism.
Without the Krebs Cycle, mammalian and most other animal life would not be viable and the world would be populated by anaerobic bacteria.
Garcinia, Hydroxycitric acid and weight loss
December 03, 2009 01:10 PM
Garcinia is part of the plant genus in the family Clusiaceae. This plant is native to Asia, Austrlia, tropical and southern Africa, and Polynesia. The number of species of the garcinia plant is highly disputed, but various sources recognize between fifty and three hundred species that are specifically valid. The plants in this genus are commonly called saptrees, mangosteens, or monkey fruit.
Garcinia is a little-known fruit that can be found growing extensively in India and Thailand. Used for centuries as a condiment, garcinia is also known as Malabar tamarind or Gorkapuli. The garcinia fruit is about the size of an orange and orange in color. However, it looks similar to an acorn squash in appearance. With approximately two hundred different species of garcinia, only few contain the needed component necessary for herbal health. Scientists have identified the natural compound found in garcinia to be hydroxycitric acid, which can help to curb appetite, reduce food intake, and slow the body’s fat production.
Hydroxycitric acid, that active component in garcinia, is similar to the citric acid that is found in citrus fruits like oranges, lemons, and grapefruit. The garcinia fruit is actually composed of about fifty percent hydroxycitric acid. This acid seems to have potent fat-fighting properties and is known for its ability to block the formation of fatty tissue, which results in less storage of fat. The rind of the garcinia fruit contains high amounts of hydroxycitric acid, which inhibits Citrate lyase, which is an enzyme require to manufacture body fat. The hydroxycitric acid combines with Citrate lyase, which leaves less of the enzyme available to form body fat and speeds up the fat-burning process. Some studies have found that fat production may actually be reduce by as much as seventy percent when taking hyroxycitric acid. Studies have determined the significant weight-loss benefits on both animals and humans when using garcinia. One study, which involved fifty obese patients, gave 500 mg of garcinia rind to these patients daily, along with 100 mg of chromium. This was also combined with a low-fat diet. The individuals who were taking the garcinia-chromium lost an average of eleven pounds, while the control group reported only a four-pound weight loss.
Garcinia has been found to be beneficial in curbing the appetite, which aids in weight control and obesity. One study on animals found appetite reduction in lean and fat rats and mice. The animals ate less, and when hyroxycitric acid was added to their diets, their body fat decreased, but body protein was unaffected.
Garcinia is also thought to help burn fat through thermogenesis. When there is not enough thermogenic activity, weight gain can result. The thermogenic activity in garcinia is responsible for helping to increase heat production, specifically in brown fat, which is the body fat surrounded by blood vessels and energy cells. Brown fat is harder to lose because it requires more heat to burn.
The fruit of the garcinia plant is used to provide anorectic, anticatarrhal, astringent, demulcent, and thermogenesis properties. Primarily, garcinia is extremely helpful in dealing with excessive appetite, obesity, and weight-related conditions. Look to your local or internet health food store for this and other great products to help with weight loss.
Calcium, Magnesium And Vitamin D
June 24, 2009 12:14 PM
In February 2006, the findings of an $18 million double-blind placebo-controlled study were published in the New England Journal of Medicine. This study was conducted by the Women’s Health Initiative (WHI) and was on the protective effect of calcium and vitamin D. The New York Times reported on this study, declaring that the study found that there were no clear benefits to calcium pills. In this article, the fact that the women who stuck to their supplementation regime experienced 29% reduction in hip fractures was dismissed. This result is rarely achieved, even with use of the strongest pharmaceuticals.
This study was designed to determine whether postmenopausal women who were given calcium and vitamin D would have a lower risk of hip fracture. The intervention group was given 1,000 mg each day of calcium carbonate, along with 400 IU of vitamin D. Although these women portrayed a greater preservation of hipbone density, the decrease in risk of fracture of 12% was not significant as a whole. The fact that many of the women who were included in the study were under sixty, and therefore, not typically at risk for fractures, causes these results to be unsurprising.
The results that were found were also skewed as a result of the fact that compliance with the prescribed daily intake was only 59% by the end of the study. 41% of the study participants had fully stopped taking the prescribed daily dosage of calcium and vitamin D, with 24% having discontinued the supplementation altogether. With such an unexpectedly low compliance rate, along with the fact that the projected hip fracture rate was over twice what was actually observed, the power of the study was reduce to only 48%. As a result, the trial had less chance than a simple flip of a coin to find anything but the largest of differences in a risk for fracture.
Despite these shortcomings, the researchers looked at the subgroups, and found different pictures emerging. Looking only at the women who mostly stuck to their prescribed regime, researchers found that a reduction in fractures of 29% was experienced. Additionally, those women over sixty experienced a reduction in the risk of fracture of 21%. These results are actually remarkable, especially after considering the many problems which clouded the accuracy of the data. Unfortunately, reporters did not look at these findings, causing a slanted account of the study to be published. Because of this, the media failed to acknowledge what were actually significant findings.
Additionally, the design of the WHI study disregarded the fact that a reduction of fracture risk is actually dependent on several factors other than calcium. Studies have actually shown that magnesium is also of equal important in the treatment and prevention of osteoporosis, as a deficiency plays a central role in the development of the disease. Postmenopausal women and those women with osteoporosis usually have low bone-magnesium content, exhibiting other indicators of magnesium deficiency that are not seen in non-osteoporotic women. Also, calcium competes for absorption with magnesium, meaning that postmenopausal women who increase calcium intake without also increasing magnesium intake can impair their absorption of magnesium. With this knowledge, the failure of the researchers to include magnesium supplementation along with calcium and vitamin D caused the potential for a study that could cause harm on the patients. With the results as they are how can we trust studies that are conducted when the patients who participate do not follow the rules? For those who want to prevent osteoporosis, calcium, magnesium, and vitamin D when taken together can help slow and prevent the onset of brittle bones.
Calcium, magnesium, and vitamin D come in capsule, tablet, and liquid softgel forms at your local or internet health food store. Always look for a name brand calcium, magnesium, and vitamin D supplement to ensure quality and purity of the product you purchase.
August 28, 2008 09:33 AM
Garcinia Cambogia is found naturally in India and parts of Asia, and also on the Pacific coast of South and Central America all the way from Peru up to Mexico, and likes a humid forested environment. Also known as Brindall berries, garcinia is believed to act as an appetite suppressant and allows you to lose weight by diminishing your desire for food.
The Malabar tamarind, as it is also known, is about the size of an orange resembling a small pumpkin, and an extract from the fruit and rind is used in several weight loss products. The health risks presented by synthetic diet pills render a natural product extremely attractive were it to be effective. So can Garcia curb your appetite? What is the scientific evidence for it, and what biochemical route would it take?
Although tests on animals have been very positive, human results have been inconsistent. In some double blind tests using a placebo, weight loss was up to three times that of the control, but in others there was no apparent difference between those taking garcinia, and those given a placebo. However, doubts have been raised of the validity of some of the negative tests, so what does science tell us?
The active ingredient in the cambogia extract is hydroxycitric acid (HCA), which is a powerful inhibitor of ATP Citrate lyase, an enzyme that catalyzes the reaction between Citrate and Coenzyme A to Acetyl CoA and oxaloacetate. Since the acetyl CoA is necessary in the synthesis of fatty acids and lipogenesis (the conversion of glucose to fatty acids), then anything that inhibits the biosynthesis of acetyl CoA must help to reduce the amount of fat stored in your body.
By inhibiting this reaction, that occurs outside the mitochondria so is not a direct part of the Citric Acid Cycle, HCA should theoretically suppress the formation of fats from carbohydrates, reduce food intake and thereby induce weight loss. But that is not the only mechanism.
A study at Georgetown University in Washington found that after 8 weeks of taking the garcinia extract, there was a 5.4% reduction in body weight and body mass index, and a significant reduction in low density lipoproteins (LDL) and triglycerides with an associated rise in high density lipoproteins (HDL). This is good news for those suffering from high cholesterol levels, since the LDL lipoproteins are those that carry cholesterol to the major blood vessels, and which when oxidized by free radicals deposit fatty plaques on the artery walls. These plaques constrict the arteries and the resultant atherosclerosis can lead to cardiac problems and strokes. HDL lipoproteins carry cholesterol back to the liver for destruction, and is known popularly as ‘good cholesterol’.
The studies also indicated modifications to certain indicators of the status of fat deposits in the body and of appetite modifiers in the brain. In this respect they found 38% decreases in serum leptin and increases in serotonin levels of 44%, and the excretion of fat metabolites in the urine increased from between 32% and 104%.
These are significant findings, and further research has indicated that HCA helps to suppress appetite. Serum leptin is an indicator of the level of fat stores in the body, and as the leptin levels in the blood reduces, the hypothalamus is given an instruction to increase the appetite so as to increase the fat levels again. However, it is believed that HCA possesses leptin-like properties, and this signal is either not generated or is modulated.
The increase in serotonin has the same effect. It is known that serotonin controls the appetite, although the exact mechanism has not yet been established. What is known is that serotonin activates certain neurons and melanocortin-4 receptors (MC4R) in the brain, that not only curb appetite but also block the effect of other neurons that would normally increase appetite by blocking the effect of MC4Rs.
This is how the banned anti-obesity and serotonin inciting drug Fen-Phen operated, and it appears that the hydroxycitric acid in garcinia cambogia extract acts in a similar, but safer, way. The problem with drugs such as Feb-Phen was that they created cardiac problems which could be dangerous to obese people whose hearts might have been weakened.
However, now that the biological pathway by which serotonin controls weight is believed to be known, if not fully understood, the way is becoming clearer as to how safer weight loss pills, acting through appetite suppression, might be developed. It also provides a valid scientific explanation for the effect of garcinia cambogia extract which might in itself prove to be that safer way.
The biochemistry supports the evidence of its effect on those wanting to lose weight, and also bolsters the claims that those tests and trials found to be negative were in some way flawed. Until the full chemical pathway is understood, the factors that can lead to flawed tests are unknown, although one could be the use of excessive fiber in some trials that could reduce the effect of the extract.
One of the effects of HCA is to limit the ability of your body to convert carbohydrates into fat (the Acetyl CoA inhibition mentioned above). That, combined with suppression of your appetite and a higher rate of thermogenesis, prevents the body from storing excess carbohydrates as fat. Instead you will have increased energy levels, so you should exercise to use this up while taking garcinia extract. For this reason it is popular with athletes and bodybuilders seeking an energy source that has not yet been banned from sport.
Although diet pills based on the same principle had side-effects and could make the user feel on edge, there are none known with garcinia. However, it is possible to reduce the absorption of some essential nutrients due to appetite suppression, so do not exceed the recommended dose. An excessive amount can also led to gastric discomfort, but none of these effects have been noted when the recommended doses have been adhered to.
However, if you are diabetic, pregnant or a nursing mother, you should consult with your physician or health professional before taking the extract. Garcinia Cambogia presents no specific risk to such people, and this warning should be given for all non-prescriptive treatments that your physician might be unaware of you taking.
July 08, 2008 03:00 PM
Garcinia cambogia is a small tree bearing a small pumpkin-like fruit of the citrus family, and is steadily appearing in an increasing number of weight loss supplements. It is indigenous to parts of Africa and Asia, and the rind is commonly used in Indian cookery.
Although the fruit is particularly sour to the taste, it is used in form of an extract of the rind and claimed to act as an appetite suppressant and also to increase the body’s capacity to metabolize fat. Although there are conflicting claims being made about its efficacy, or lack of it, research shows that it definitely has promise as an agent to prevent and fight obesity and its use is steadily increasing in this respect.
The active ingredient is hydroxy citric acid, otherwise known as HCA, contained in the form of the potassium and calcium salts of the acid in the aqueous extract of the garcinia cambogia rind. It forms up to 30% by weight of the rind. It is tasteless and odorless, and so far found to have no toxic effects on humans. Animal studies have also been generally favorable.
HCA works in two specific ways both to reduce the desire to eat and to inhibit the storage of fat in the body. In each case, as with so many supplements that have an inhibitory effect on a physiological or psychological function or on a metabolic process, it involves an interaction with enzymes.
Citrate lysase is an enzyme in the body that helps to prevent lipogenesis and instead promotes the conversion of carbohydrates into fat. When this enzyme is inhibited from carrying out its intended part in the body’s metabolism, the process of carbohydrate oxidation is boosted, or, in other words, the excess carbohydrate is burned off, or changed into energy.
More fats could also be expelled unchanged from the body, but irrespective of that the end result is that less carbohydrate tends to be converted to fat. Garcinia cambogia, however, has not been found to reduce the body’s uptake of essential fatty acids which are necessary for health. Had this occurred, you would feel a raging hunger as opposed to the appetite suppressing properties the extract is claimed to have.
The oxidation of carbohydrates can also lead to thermogenesis, or the boosting of the metabolism by increasing your body temperature. An increase in the metabolic rate helps weight reduction through an increased calorie demand while your body is at rest. However, that is not the only way in which the HCA extract works to help reduce your weight, or at least help to maintain it at a healthy level. Let’s return to its specific appetite suppression properties.
Serotonin (5-hydroxytryptamine) is a neuroreceptor found in the central nervous system. It has many regulatory effects on the body, one of which is appetite. Although it is by no means the only chemical in the body that has an effect on the appetite, serotonin is a significant factor. As you get hungry, serotonin is released in the hypothalamus, an area of the brain that regulates sleep and eating. The release of serotonin increases when you see and or smell food. It is the agent that starts canine salivation, and a ravenous hunger in those that have no immediate access to food.
It also causes you to snack, and, as you eat, the serotonin level in the hypothalamus continues to increase until it reaches a point where it provides the hypothalamus with a feeling of repletion or satisfaction. You then stop eating. So the more serotonin is produced, the quicker you stop feeling hungry.
Garcinia cambogia extract has the effect of stimulating the emission of serotonin into the hypothalamus, and so suppresses your hunger quicker. You don’t stop eating altogether, but attain that feeling of satisfaction much quicker and so tend to eat less with each meal. This can not only help you maintain your weight at a healthy level, but also to reduce weight in the obese.
Although the extract can work through each of these mechanisms, it does not have such a significant effect on a very fatty diet. It can help if you switch to a relatively healthy diet, lower in fats, but the effect might not be strong enough to compensate for a poor diet in terms of fat content.
Studies have indicated an anti-oxidant activity that likely comes from the xanthones and xanthone derivatives that are also contained in the fruit. In fact there are other recorded uses of garcinia cambogia, and it has been used in traditional Indian medicine to treat fevers, dysentery, open wounds, ulcers and tumors.
According to a study carried out for the National Cancer Institute there is no documented toxicity effects on humans, and there is no regulation regarding the use of garcinia cambogia. It has not been evaluated by the FDA.
However, there are contra-indications in the case of pregnant and lactating women, more as a safety measure than for any particularly known risk. Alzheimer patients should avoid taking HCA since there is a possibility of it promoting the synthesis of acetylcholine in the brain, and its glycemic action renders it unsuitable for diabetics.
Conversely, this same action is a positive benefit by reducing the craving of healthy adults for sweet foods. However, HCA is frequently taken in combination with chromium due to the latter’s positive effect on the regulation of blood sugar levels. Nevertheless, diabetics should avoid any supplement containing chromium without professional medical advice.
The supplement should be standardized on the HCA content, and an average dose is around 500 mg – 1000 mg of 50% extract a day. However, this varies, and the most important aspect of such extracts is that when changing brands; be sure to compare the strength of the relative extracts and change your dosage accordingly.
Although the benefits of garcinia cambogia to those seeking to lose weight are debated, there is ample evidence to suggest that a regular intake of the extract is beneficial – and not only with respect to the maintenance of healthy weight.
Supports Healthy Blood Pressure
April 18, 2008 03:59 PM
3 tablets contain:
Suggested Use: 3 tablets mid-morning and 2 tabs mid-afternoon between meals on an empty stomach.
Did You Know There Is One Mineral That Could Change Your Life Forever?
March 05, 2008 04:05 PM
Did you know there is one mineral that could affect the way you feel and change the way you live life forever? Yes that’s correct – forever - magnesium is that mineral! More than 50% of all Americans consume less then the required amounts of magnesium to stay healthy.
You might be wondering how you would know if you are deficient in magnesium and where you can get a test. Unfortunately it is not that simple. A magnesium test is available from your doctor, but when most people take this test, the results normally come back as normal, so we think everything is fine. This test only measures blood serum levels and not cellular magnesium. One needs to have their red blood cells tested to accurately measure the uptake of magnesium and at this time. This kind of testing needed is not readily available.
You might ask, “how can I tell whether I have a deficiency or not?” It is simple, look at your medical history. Symptoms of magnesium deficiency include signs such as, muscle cramps or twitches, insomnia, irritability, sensitivity to loud noises, anxiety, nervousness, autism, ADHD, heart palpitations, angina, constipation, spasms in the muscles, headaches, migraines, fibromyalgia, chronic fatigue, asthma and kidney stones (typically caused by a calcium-magnesium imbalance), diabetes, obesity, high blood pressure, menstrual cramps, irritable bladder, irritable bowel, acid reflux, and premenstrual syndrome, depression, low energy, weakness in the muscles, weakening bones, and calcification of organs.
If you did not notice, this is an extensive list of symptoms that may be attributed to a deficiency in magnesium. Magnesium is essential for cardiac function in stabilizing cardiac membranes preventing arrhythmias. This mineral helps the cardiovascular system relax aiding in the relief of angina symptoms. Millions of Americans are diagnosed with heart disease yearly, a magnesium deficiency may be the cause.
The reason we are deficient in magnesium is mostly due to the fact that we eat refined, over-processed foods with white flour that have absolutely zero magnesium. The consumption of foods not rich in magnesium will rob our bodies of the little we still have in our bones and organs. Drinking coffee, alcohol, eating lots of sugary foods and stress will cause the body to become depleted.
If you are experiencing one of the above mentioned symptoms and suspect you have a magnesium deficiency, changing they way you eat can help. Pick up a nutritional almanac and find foods high in magnesium like nuts, sea vegetables, dark leaf vegetables and beans to start. Also, kelp, wheat bran, wheat germ, buckwheat, millet, brown rice, rye, tofu, soybeans, brown rice, figs, dates, avocados, parsley, barley, dandelion greens and garlic all contains high amounts of magnesium. Adding a magnesium supplement to your diet which provides 200 to 400 milligrams per day will help. One should limit the intake of coffee, alcohol, colas, salt, and sugar. Actually, many medications can deplete the body of magnesium such as water pills (diuretics) and antibiotics to name two.
So now you know what to do, you might be thinking that a magnesium supplement would be the fastest way to boost magnesium in the body for the time being. What form of magnesium is best? The recommended form of magnesium is magnesium Citrate, because of its digestibility and absorbability in the body. Avoid magnesium carbonate, sulfate, gluconate, and oxide if at all possible for these forms of magnesium are harder to digest and will result in smaller amounts being absorbed by the body. Now what are you waiting for, give magnesium a try and see how good you can feel from it!
Which Form Of Calcium Is Best For You?
January 15, 2008 05:10 PM
There is no warning signal that lets you know if you have a calcium deficiency. Actually, a calcium deficiency is usually undetectable until damage that is irreversible has already occurred. A calcium deficiency is extremely hard to detect because the calcium level in the blood may seem to be normal, even if extreme cases of deficiency are actually occurring. This is because the body has a calcium bank, which can be found in teeth and bones. Calcium is needed in order to control muscular contractions such as the heart, blood-clotting, transmission of nerve impulses, and other requirements which take priority.
You may not know for sure whether you have calcium deficiency until you experience loose teeth, receding gums, or a bone fracture. At this point you will realize how brittle and chalky your bones have become. There is no known cure for osteoporosis, and it seems to be affecting people at younger ages more and more. The progression towards this illness takes years, but it is going on unnoticed in a great percentage of our population right as we speak.
There are many reasons why calcium deficiency is so widespread. First, calcium is not easily absorbed, as no more than 10-20% of what is found in foods is actually consumed and metabolized. This is because a meal that is high in fats can form insoluble calcium soaps which cause calcium to pass through the system without being absorbed. Also, the calcium in certain vegetables can actually be inhibited from releasing by oxalates that are found naturally in foods such as rhubarb, kale, spinach, broccoli, grains, and cereals.
Furthermore, vitamins A and D must be present in the body in order for absorption to occur. Additionally, calcium requires an acid environment for absorption, which is a huge problem for older people who have less production of digestive acids. More so, amino acids are needed for the formation of calcium-amino acid complexes and magnesium and phosphorus must be present in a precise ratio’s. Without all of these factors, you can lose a lot of the benefit, no matter how much calcium you are taking in.
A great variety of calcium supplements can be found in your health food store. These supplements can range from a simple calcium carbonate to bone meal, dicalcium phosphate, dolomite, calcium lactate, calcium gluconate, and many others. Although they all contain calcium, they vary in the amount of actual calcium content from 40% in calcium carbonate to 9% in calcium gluconate. Calcium carbonate has the highest percentage calcium per gram, but it acts as an antacid which makes this supplement somewhat useless since calcium can only be absorbed in an acid environment.
Acid breaks down the bonds between the calcium element and its bonding partner like carbonate or amino acid chelate. Calcium Carbonate has a carbon bond the strongest bond of its kind; this makes it extremely unwise for those people who are older or suffer from a digestive acid deficiency. Calcium carbonate that is derived from oyster shells is no different from any other form. However, oyster shells carry an additional risk of being contaminated with naturally occurring heavy metals found in the oyster bed environment. Calcium phosphate is probably the best source of calcium, since the principle calcium in the body is actually calcium hydrogen phosphate which is easy to digest.
Whether you choose calcium carbonate or calcium Citrate, ask your local health food store which calcium is best for you depending on your age and whether you have a digestion disorder or not. With poor diets and lack of exercise, calcium supplementation is a must for most people. Have you had your calcium today?
Looking For A Calcium But Not Sure Which Is Best For You?
November 02, 2007 12:23 PM
Calcium is essential to good health, but if you are looking for calcium it can be confusing to decide in which form you take it. There are so many available and every one claims to be good for you, so why the difference? Why not just sell the best and let us all know what it is? Well, this same argument could be applied to all supplements that are sold in different forms, and also to many foodstuffs.
The supplement best for you might not be the best for the next person due to dietary requirements each persons diet is different, so it is better to learn about what is available then make your choice based upon knowledge rather than ignorance. It is not only the source of the calcium you have to bother about, but also the other vitamins that have be present to make sure that that the calcium is absorbed by the body in the way that you want it to be.
To understand that then you need to learn why the body needs calcium, other than just the bones and teeth that everybody knows about. After all, why else do we need calcium? It is only contained in bones and teeth – right? Wrong!
Although 99% of calcium is contained in your bones and teeth, 1% is contained in the blood, muscles and central nervous system. With out that 1% we would all die. Without teeth we would not. Calcium is essential for blood clotting and for the proper function of our muscles, brain and central nervous system. Calcium combines with phosphorus to create healthy bones and teeth, and is essential early in life to build up a strong skeleton. Note that phosphorus is also necessary so we also need an adequate supply of that mineral.
Calcium is essential to allow muscles to properly contract. Without that ability, muscles could not work, and a deficiency of calcium causes muscle cramps and spasms. The movement of the smooth muscles is regulated by a protein that is bound to calcium. This is just one of the uses of the calcium in the body that most people are unaware of.
Calcium also takes part in the binding process of the blood platelets during the coagulation of blood. Although most people are aware of the need for vitamin K and fibrin, in fact calcium is also essential in its interaction with the platelets in the coagulation cascade that eventually results in a blood clot that stops bleeding. Basically, without calcium, the blood could not form a clot. In addition to its effect on blood clotting, calcium also plays an essential part in the movement of ions through the membranes of nerve cells, and without it intercellular communication could not occur. Our nerve impulses would not occur and the body again would not be in a working condition.
However, the body has a way of modulating the calcium level in the blood past a minimum level needed for effective nerve cell communication, and below a certain level it can even use the calcium in the bones to divert to the more needy areas of the body. It is therefore not possible for the body to fail through a lack of calcium. The skeleton would disintegrate first. Nevertheless, nobody wants a disintegrating skeleton since that would be counterproductive to effective movement of the body, so a good source of calcium is essential for overall bodily health, not just that of the teeth and the bones.
There are many sources of calcium, but some are more suitable for absorption by the body than others. Chalk, or calcium carbonate, is an excellent source of calcium, but will fail to promote bone growth if your diet does not contain sufficient potassium, vitamin D, magnesium and strontium needed to make it work to build healthy bones. It is the most common on the shelves, and likely the cheapest, but not necessarily the best source. It is basically chalk or limestone, and only 10% of the supplement will actually become available for your body to use.
The bioavailability of a calcium supplement is a figure that indicates how much of the calcium is actually absorbed by the body during digestion. It is important that the supplement is digested and absorbed properly or the calcium will not be available for use. This availability is called the ‘bioavailability’. Calcium Citrate has a bioavailabilty of 50%, but the size of the Citrate part of the molecule is so large that only 10.5% of the molecule is available to the body as calcium. Not much more than the carbonate.
Calcium aspartate is highly soluble and produced by reacting calcium with aspartic acid to form the soluble salt. It is much easier to assimilate and be absorbed by the body than any of the forms above. The amino acid, aspartic acid, delivers the calcium exactly to where it is needed, where it is absorbed and used. Although a bioavailability figure is not available, it is not the amount of calcium that is significant here but the fact that it comes with its own transportation system and is immediately available where needed.
If you want to calculate the availability for yourself, find the molecular weight of the particular calcium product, and then the weight of the calcium contained within it. For example, in calcium carbonate, CaCO3, the molecular weight is 100 (40 + 12 + 3x16) and the atomic weigh of calcium is 40, so the amount of calcium present in 1000g calcium carbonate is 40% or 400g. Only 25% of calcium carbonate is absorbed, so only 10%, or 100g, of calcium is available for each 1000g supplement.
Calcium Citrate on the hand (Ca3(C6H5O7)2.4H2O) has a molecular weight of 570, so the amount of calcium present is 3*40*100/570 = 21%. Since the bioavailability of calcium Citrate is 50%, the amount of calcium available is only 10.5%, or 105g in 1000g Citrate. You can carry out the same calculation on all the molecules if you know how much is absorbed by the body.
The bioavailability is calcium aspartate is 85%. Its molecular formula is [C4H6NO2]2Ca, and molecular weight 304. The calcium availability is therefore 40*100/304 = 13.16%. If 85% is absorbed, then 1000g provides 80% of 13.16 x 10 = 115.6g. The aspartate therefore wins it.
Amino acid chelates can also be used as a source of calcium, and its bioavailability is improved tremendously by including vitamin D and magnesium in the supplement. The bioavailability of these calcium chelates are not quoted, but is claimed to be high. Whether or not it is as high as the aspartame is debatable, though it is claimed to be.
Calcium is a very important mineral for human health, and there are several different supplements that can be used. The bioavailability of the calcium is different in each supplement, though the organic forms, calcium aspartate and amino acid calcium chelates appear to be the highest. When looking for a calcium supplement look for one with additional minerals added as mentioned above to help improve absorption and usability by the body.
This sour Indian fruit can have a sweet appetite-stifling effect
May 26, 2007 05:44 PM
Stay satisfied with garcinia
This sour Indian fruit can have a sweet appetite-stifling effect.
It’s funny how modern science continues to support ancient systems of herbal healing. Such is the case with garcinia: the yellowish, pumpkin like fruit of the Garcinia cambogia tree, log valued in tropical Asian cooking for its sweetly acidic taste, is a traditional Indian remedy for digestive problems that is also used to make meals more filling. Today, garcinia (also known as brindleberry and Malabar tamarind) is used in natural weight-loss products based on research supporting its stomach satiating powers. Scientists also believe that garcinia helps block fat formation and regulate glucose (blood sugar) usage vital functions in an increasingly overweight world.
Filling up Faster
One reason so many people losing the battle of the bulge is that temptations to eat – and eat – are absolutely everywhere, often as the focal points of clever and well designed advertising campaigns. (Remember the slogan “belch’a can’t eat just one”?) To make matters worse, restaurants often serve overly generous portions and experiments have shown that the more food you serve, the more people will consume. For example,
The answer would seem simple – just eat less. But knowing when to say when isn’t easy. That’s where garcinia comes in, specifically an extract taken from the rind called HCA (Hydroxycitric acid). In laboratory animals HCA has upped levels of serotonin, a brain chemical that helps suppress appetite and elevate mood, which might help take the edge off the depressing and binge-eating urges that often affect would-be weight losers. At the same time HCA appears to reduce levels of another substance in the brain called neuropeptide Y, which enhances appetite (Experimental Biology meeting 4/06).
What is it: the pumpkin-like fruit of the garcinia cambogia tree; this Indian native is used in cooking and in Ayurveda, the country’s system of traditional medicine.
What is does: A popular ingredient in natural weight-loss aids, garcinia is being investigated for possible fat blocking and appetite-suppressing functions; it may also help regulate glucose (blood sugar).
Fat Smack down
The fat that stubbornly clings to your frame doesn’t always start out that way. In many cases, your body actually creates fat from excess carbohydrates (such as the icing encrusted doughnut you couldn’t pass u at breakfast). If you don’t burn off those extra carbs through exercise, they are broken down into Citrates that are then transformed into the building blocks of body fat. This process is controlled by an enzyme called Citrate lyase; HCA interferes with this crucial enzyme, an action that inhibits fat formation. Researchers believe the body uses those extra carbs to provide more energy; this mechanism may also have the happy side effect of further checking appetite. In addition, results from a Dutch lab study indicate that garcinia may blunt sugar-induced increases in glucose, which can help forestall diabetes development.
Garcinia works best when teamed with out nutrients and herbs, such as chromium, green tea and forskolin. In one investigation, over weight people who stuck to a supervised diet and exercise program supplemented with a combination of HCA, chromium and another herb called Gymnema lost body weight and mass, and showed improved fat burning capacity (Nutrition Research 1/04). This modern usage mirrors Ayurveda’s ancient precepts, according to which individual remedies are generally used in combination for more effective results. Looking to get your meals more staying power? Then look for garcinia in your favorite weight loss formula. –Lisa James
Growing Older, Feeling Better
March 28, 2007 02:15 PM
Growing Older, Feeling Better
Not long ago, when a man turned sixty-five, he became officially old – the best years of his life far behind him. The milestone meant his working days were done and if he was lucky, he might get four or five years to spend as he wished before illness and infirmity set in. It was simply expected and accepted that the older a man got, the sicker he got.
Well, not anymore. Today, a man age 65 is just as likely to be found hiking in the hills, running in a marathon, or even dancing in the streets than rocking in that proverbial front porch rocker. Because it’s becoming more and more evident that the older a man gets, the healthier that man has been.
Eating healthy, exercising, and kicking harmful habits (like smoking) can add years to a man’s life. Aging research is proving over and over again, that we can prevent and delay heart disease, cancer, diabetes, and Alzheimer’s disease – the major causes of disability and death in men over 50.
Now, it’s very true that good clean living from early on is preferable to sixty five years of bad habits and five years of good. But it’s also true that it’s never too late for men to make changes and vow to take better care of themselves. And one of the easiest and most effective ways men can improve their health is the addition of high quality nutritional supplements.
In this issue of Ask the Doctor, we’ll talk about specific dietary supplements that have been scientifically shown to improve the health of men over fifty, prevent the diseases that often strike at this crucial time in men’s lives, and actually slow the aging process.
Q. I just turned 50 and I’d like to begin taking nutritional supplements, but they seem so confusing. Where should I begin?
A. Many men feel the same way. There are literally hundreds and hundreds of nutritional supplements on health food store shelves. Figuring out which supplements provide the best health benefits for a 50+ man can be overwhelming.
The best foundation supplement is a high quality multivitamin. Research is repeatedly finding that even very healthy men who take daily multivitamins can significantly improve their health. In fact, an article published in the Journal of the American Medical Association (JAMA) recommends that all adult Americans take a vitamin supplement. Look for solid doses of vitamin supplement. Look for sol doses of vitamins and especially minerals. Multivitamins designed to be taken once a day are often woefully deficient in calcium, magnesium, and potassium. The only mineral a man should avoid is supplemental iron. Iron should only be in formulas for women prior to menopause. Men over 50 get all the iron they need from food and too much iron can cause health problems.
Look for men’s multivitamins that contain lycopene in the formula. Lycopene is the pigment that makes tomatoes red. The redder the tomato, the more lycopene is present. Numerous studies have shown that when men have high lycopene levels in their blood, they have a much lower risk of heart disease, age-related macular degeneration (a leading cause of vision loss) and prostate cancer.
Other important considerations are antioxidant blends, especially fruit- and tea-derived extracts; ginseng for energy and stamina; and digestive enzymes to aid in absorption and compensate for age-related decreased enzyme levels.
In fact, years of research has shown the foods a man chooses to eat (or not to eat) can have a profound impact on the health of his prostate gland. Because of this close nutritional link, prostate cancer may be the most preventable type of non-smoking related cancers.
Q. Aside from taking a quality multivitamin for general health, what nutritional supplements prevent and treat prostate cancer?
A. Six vital and all-natural nutrients can prevent prostate cancer from developing and even help fight the disease.
When men are exposed to excess levels of hormones, their risk of prostate cancer increases. A natural substance found in fruits and vegetables called calcium D-glucarate (or CDG), helps men’s built-in detoxification systems get rid of these harmful excess hormones.
This antioxidant has powerful effects on the prostate gland. In a recent study, researchers recruited 974 men to take part in a large clinical trial to determine if selenium could prevent cancer. The researchers found that selenium cut the rate of prostate cancer by 63%!
Green tea is the most widely consumed liquid in the world, after water. Men in
For many years, maitake mushrooms, or dancing mushrooms, have been linked to good health in those who eat them. That’s because maitakes contain an important compound called D-fraction. A recent study showed that maitake D-fraction destroyed 95% of human prostate cancer cells in lab experiments.
Promising preliminary reports demonstrate that lycopene can actually kill prostate cancer cells, so there has been an explosion of lycopene and prostate cancer research.
Q. What exactly happens to men’s hormones as they get older?
A. Just as women experience significant hormonal changes as they age, so do men. In fact, the term andropause has been used to describe men’s mid-life changes. Similar to menopause in women (where the decline of estrogen causes a myriad of symptoms), andropause in men signals the slow decline of testosterone, the chief sex hormone in men. While estrogen levels decline faster and more abruptly in women than testosterone levels do in men, testosterone decline can cause a number of unpleasant symptoms. These include abdominal weight gain, hair loss, reduced energy and sex drive, heart disease, and prostate enlargement. Whether a man labels these age-related changes as andropause or just the consequences of aging, most men will unfortunately experience some or all of them as their birthdays mount.
Q. So, is there a supplement that can give me the hormone level of a 20 year old?
A. Sadly, no, at least not yet! But there is a nutrient that can help the testosterone in a man over fifty “behave” more like a younger man’s testosterone.
A study that took place at the
The secret of DIM’s prostate cancer prevention is its ability to metabolize estrogen. While estrogen is generally thought of as a “female” hormone, a precise ratio of testosterone-to-estrogen is needed to maintain a man’s healthy sexual response, effective sexual function (erection of the penis and intercourse), strong bones and muscles, viable sperm, and a well-functioning prostate gland. As men enter their fifties, this ratio begins to change.
When men take DIM, however, their estrogen metabolism improves, testosterone metabolism accelerates, and the unwanted conversion of testosterone into estrogen is eliminated. This results in higher testosterone levels, similar to those seen in young men. As a result, DIM may speed weight loss, reduce prostate gland enlargement (benign prostatic hyperplasia or BPH), and help men over 50 feel stronger and leaner.
Some supplements on the market today contain indole-3-carbinol (I3C), a precursor to DIM. However, I3C is unstable and requires activation in the stomach to be converted into DIM. This means I3C must be taken at a much higher amount and can undergo unpredictable and undesirable chemical reactions in your stomach and colon. DIM is by far the preferred supplement.
Q. What is saw palmetto? Does it reduce symptoms of Benign Prostate Hyperplasia (BPH)?
A. Yes it does and very effectively too. Saw palmetto is a small palm tree native to
The prostate gland is about the size of a walnut and is located below the bladder and in front of the rectum. It wraps around the upper part of the urethra and its primary job is the production and storage of semen, the milky fluid that nourishes sperm. BPH is one of the most common health conditions in older men. Half of all men aged 40-60 and more than 90 percent in men over 80 have BPH. BPH causes the prostate gland to enlarge, putting pressure on the urethra.
Men have trouble starting or maintaining a stream of urine, find they can’t completely empty their bladders, and have to urinate frequently, even during the night. They may also have episodes of uncontrollable dribbling or complete loss of urine. BPH is caused by the conversion of estrogen to a very potent form of testosterone called, dihydrotestosterone (or DHT). When prostate cells are exposed to DHT, they multiply in number and get much larger.
BPH rarely improves. It most often remains the same for years or gets gradually worse. The need to continually urinate, interrupted sleep, dribbling, and loss of urine can significantly interfere with a man’s quality of life. Prescription medications that have been developed to treat BPH are only partially effective. And surgical removal of the prostate gland may result in even more persistent urinary incontinence and the inability to achieve an erection (ED).
However, saw palmetto berry extract relieves the symptoms of BPH by inhibiting the production of DHT. And, in study after study after study, saw palmetto caused none of the side effects that happen with prostate surgery or medications.
Q. There seem to be plenty of ads for supplements that claim they make men into Sexual Superheroes. Is there an “honest” nutritional supplement to help me sexually?
A. That’s a very good observation. And yes, there are honest nutritional supplements for men’s sexual health.
Sexual intimacy is an important, complex, and lifelong need. It makes us feel better physically and mentally and adds to our sense of security, belonging, and self-esteem. But just like other changes that happen to men as they get older, men’s sexual response most often changes, too. Declining testosterone levels, changes in blood flow to the penis, certain medications that older men are prescribed, and the presence of diabetes or heart disease can all affect men’s ability to engage in sexual activity.
When men have a chronic inability in obtaining and/or maintaining an erection, it’s called erectile dysfunction (ED). While ED is not an inevitable part of getting older, it does occur more frequently as men age. About 5% of 40-year-old men have ED, but more than 23% of 65-year-old men have difficulty maintaining erections.
The development of prescription medication Viagra (sildenafil Citrate) has revolutionized ED treatment. When a man is sexually stimulated, Viagra helps the penis fill with enough blood to cause an erection.
Like all medicines, Viagra can cause some side effects, including headache, flushing of the face, and upset stomach. But because Viagra is a prescription medication, it requires a visit to a licensed healthcare practitioner. For many men, telling anyone (even a professional) that they are having trouble getting or keeping an erection is simply too embarrassing. Viagra is also fairly expensive and many older men do not have prescription drug health insurance.
These reasons may explain that while an estimated 30 million men in the United States – 10% of the male population – experience chronic ED, as few as 5% of men with chronic ED seek treatment.
Not every man can take Viagra, either. Men who use nitrate drugs, often used to control chest pain (also known as angina), must not take Viagra. This combination can cause their blood pressure to drop to an unsafe or life-threatening level. Men with serious liver and kidney problems who take Viagra must be monitored closely for possible serious side effects.
The good news is there is a nutritional supplement that’s formulated with vitamins, herbs, and glandular products that targets male sexual organs. The formula contains vitamin E, liver fractions, wheat germ, beta-sitosterol, and herbal extracts of muira puama, Mexican damiana, saw palmetto, cola nut, ginseng, and ginkgo biloba.
Vitamin E is a powerful antioxidant and men’s testicles, adrenal glands, and pituitary glands need high levels of this fat-soluble vitamin for proper functioning. Extracts of Muira puama, Mexican damiana, and cola nut have been studied for their beneficial effects on male hormones.
Study of ginkgo in sexual response came about when a patient in a nursing home who was taking the herb for memory enhancement noted that his erections were improved. Since then, study of ginkgo has shown it helps blood flow to the penis. Sexual response research in one ginkgo study showed that 76% of men taking ginkgo experienced improved sexual desire, erections, and orgasms.
While other nutritional supplements sold to improve sexual stamina often make outrageous claims, reputable manufacturers rely on science and results to sell their products.
An important note
Most often sexual problems are simply part of the aging process. They can also be signs of serious health problems. If the use of nutritional supplements for two months does not improve your erections, you do need to see your healthcare practitioner. Almost all practitioners understand how difficult this problem is for men to discuss and are experienced in getting the information as quickly and as painlessly as possible.
No man has the power to stop the passage of time. But every man has the power to make aging more healthy and less harmful. Research conducted on men who live to be 100 and beyond, has determined that those who reach extreme old age do so by avoiding ill health, rather than by enduring it. As I like to remind my patients, “Age is not determined by years, but by function.” And it’s never too late for men to detour around the major illnesses of getting older. With good nutrition, healthy habits, and high quality nutritional supplements, the best years of a man’s life can absolutely and positively be those he spends in his 70s, 80s and even his 90s.
This is sour Indian fruit can have a sweet appetite stifling effect.
January 13, 2007 02:44 PM
It’s funny how modern science continues to support ancient systems of herbal healing. Such is the case with Garcinia: The yellowish, pumpkin like fruit of the Garcinia Cambodia tree, long valued in tropical Asian cooking for its sweetly acidic taste, is a traditional Indian remedy for digestive problems that is also used to make meals more filling. Today, Garcinia (also known as brindleberry and Malabar tamarind) is used in natural weight-loss products based on research supporting its stomach satiating powers. Scientists also believe that Garcinia helps block fat formation and regulate glucose (blood sugar) usage—vital functions in an increasingly overweight world.
Filling Up Faster
One reason so many people are losing the battle of the bulge is that temptations to eat-and eat—are absolutely everywhere, often as the focal points of clever and well designed advertising campaigns. (Remember the slogan “belch’a can’t eat just one”?) To make matters worse, restaurants often server overly generous portions and experiments have shown that the more food you serve, the more people will consume. For example, Chicago moviegoers ate 45% more popcorn from larger containers even when they were given stale product (Food Quality and Preference 1/01).
The answer would seem simple—just eat less. But knowing when to say when isn’t easy. That’s where garcinia comes in, specifically an extract taken from the rind called HCA (Hydroxycitric acid). In laboratory animals HCA has upped levels of serotonin, a brain chemical that helps suppress appetite and elevate mood, which might help take the edge off the depression and binge-eating urges that often affect would-be weight losers. At the same time HCA appears to reduce levels of another substance in the brain called neuropeptide Y, which enhances appetite (Experimental Biology meeting 4/06).
What it is: the pumpkin-like fruit of the Garcinia cambogia tree; this Indian native is used in cooking and in Ayurveda, that country’s system of traditional medicine
What it Does: A popular ingredient in natural weight-loss aids, garcinia is being investigated for possible fat blocking and appetite suppressing functions; it may also help regulate glucose (blood sugar).
The fat that stubbornly clings to your frame doesn’t always start out that way. In many cases, your body actually creates fat from excess carbohydrates (such as the icing encrusted doughnut you couldn’t pass up at breakfast). If you don’t burn off those extra carbs through exercise, they are broken down into Citrates that are then transformed into the building blocks of body fat. This process is controlled by an enzyme called Citrate lyase; HCA interferes with this crucial enzyme, an action that inhibits fat formation. Researchers believe the body uses those extra carbs to provide more energy; this mechanism may also have the happy side effect of further checking appetite. In addition, results from a Dutch lab study indicate that garcinia may blunt sugar-induced increases in glucose, which can help forestall diabetes development.
Garcinia works best when teamed with other nutrients and herbs, such as chromium, green tea and forskolin. In one investigation, overweight people who stuck to a supervised diet and exercise program supplemented with a combination of HCA, chromium and another herb called Gymnema lost body weight as mass, and showed improved fat burning capacity (Nutrition Research 1/04). This modern usage mirrors Ayurveda’s ancient precepts, according to which individual remedies are generally used in combination for more effective results.
Looking to give your meal more staying power? Then look for garcinia in your favorite weight loss formula. –Lisa James.
Which Calcium is Best?
October 17, 2006 03:52 PM
Customers walking into a health food store today are faced with a vast array of calcium supplements. They might ask: which one should I pick? Which one is best? Not easy questions to answer. All calcium forms will accomplish the same task: providing your body with a nutrient that it needs to build healthy bones and teeth; however, which form of calcium has the features that you want in a calcium supplement? Looking at shelves of calcium products is kind of like shopping for a car; there are many makes and many models—some are basic and others are more sophisticated.
Fortunately, there are many forms of calcium to satisfy your needs. Like the car lot, a health food store offers many options; therefore, you have to select a calcium product that consumers will feel confident in taking regularly and that will provide the most benefit.
Some consumers have done research and will come armed with information. They have already made choices based on advertising, word-of-mouth or an article they have read. They already know the form of calcium they want, be it a “Ferrari” or a “Ford.” If the client doesn’t have a specific preference: asking these basic questions will help in the selection process:
1. Do you prefer tablets, capsules, softgels, liquid or powder?
2. Do you have high or low stomach acid?
3. Do you have absorption issues?
What is calcium?
Calcium (Ca) is one of the most important minerals found in our bones and teeth—99 percent of body calcium is found there. But the calcium molecule does not like to travel alone and, in its more basic state, it comes bounded to carbon (C), Oxygen (O), and/or hydrogen (H) molecules or in more complex form, it is bonded to organic or amino acids that act as stabilizing carriers. On most labels, the amount of calcium listed actually indicates the pure or elemental calcium because it is that amount of the calcium that is deemed important to our daily supplementation, not the complex of the materials with which it is bonded.
Where does calcium come from?
Other than the calcium found in bone, the only natural form of calcium found in nature is calcium carbonate, a calcium molecule bonded to one molecule of carbon and three molecules of oxygen (CaCO3). One of the most common minerals on the face of the earth, calcium carbonate is called calcite, aragonite or vaterite by geologists. In its geological form, it constitutes approximately four percent, by weight, or the earth’s crust.
Commercial sources of calcium carbonate used to make supplements are: limestone, dolomite, oyster cell, egg shell, coral and sea water (have you ever seen that white deposit left by hard water? That’s mostly calcium carbonate). Calcium carbonate is the starting material for all other forms of calcium supplements. From this starting material, calcium can be reduced to more concentrated forms, such as oxide or hydroxide or it can be chelated (bonded) to organic acids and amino acids to help support enhanced absorption.
Lets look more closely at the different forms of calcium that are available as supplements.
Calcium Oxide (CaO): this form is 71 percent elemental calcium and is also called “lime” commercially. This is one of the oldest and most inexpensive forms of calcium used in a variety of commercial applications and it is occasionally used in supplements where space and price are a factor. It sometimes can be found in inexpensive mass market calcium/mineral combinations or multivitamin/mineral products and in a unique algal calcium from Japan. Unfortunately, CaO is a strong alkali that may cause stomach distress, which is why it isn’t often used in health food supplements.
Calcium Hydroxide (CaHO): at 54 percent elemental calcium, it is the next highest source of elemental calcium and is also known commercially as “slaked lime.” It is used where space is an issue. Although it is also a strong alkali, it is more stable than calcium oxide. It is most often used as a component of multi-mineral formulations or in addition to other forms of calcium (i.e., calcium Citrate) to provide potency where space is an issue. It is not often used as a single ingredient in health food supplementation. This is for people who want a high dosage of calcium from a minimum amount of pills in multi-mineral formulas.
Calcium Carbonate (CaCO3): at 40 percent elemental calcium, it is the most widely used form of calcium in single ingredient calcium supplements as well as combination supplements. Inexpensive and an abundant source of elemental calcium, it is the only form of calcium found in nature outside of bone. It is the primary form of calcium used in the mass market and in antacid products. This is for people who have high stomach acid and who need a buffering type of calcium. Also for people who want a high dose of calcium in a minimum amount of pills.
Calcium Citrate: at 21 percent elemental calcium, it is one of the most popular forms of calcium supplements in the health food market as well as the mass market. This calcium salt does not lower stomach acid as much as calcium carbonate. This calcium salt is usually recommended for people who have low stomach acid, have had stomach surgery or who need a form of calcium that will not lower their stomach acid further.
Calcium Gluconate and Lactate: these two forms of calcium are high soluble. Since the amount of elemental calcium is much lower (9 percent and 13 percent respectively), they are used more often in powder form and mixed with liquids or food. When mixed in a beverage, the calcium is already dissolved and is ready to be absorbed. This is the best calcium salt for people who have overactive bowels, who have trouble swallowing pills or who don’t like the taste of pre-formed liquid calcium supplements. These calcium powders can be mixed in juices or smoothies or added to food as they are virtually tasteless.
Calcium Orotate and Asporotate: In the mid 20th century, Dr. Hans Nieper, a German scientist, advanced a theory that orotic and aspartic salt forms of calcium are transported directly to cell membranes for better absorption. The Solaray brand developed an asporotate formula, which combines three organic acids: aspartic acid (-Asp), orotic acid (-oro) and citric acid (-tate) into one product. The asporotate formula has become one of the most popular calcium formulas and is exclusive to the Solaray brand. This product is for customers who appreciate the idea of combining the enhanced absorbability of three organic acids into one. Aspartate and Citrate are also part of the krebs (energy) cycle and are natural to the body’s metabolic systems and, according to Neiper, calcium Orotate and Aspartate are mineral transporters that enter into the cells to facilitate enzymatic actions rather than being extra-cellular. For people who believe that intracellular calcium is of importance, calcium Orotate and asporotate may be good choice.
Calcium Hydroxyapatite: this is another “natural form of calcium usually as a mineral ash form bovine source bone. Bone meal is also a form of calcium from bovine bone. These forms of animal derived calcium are for customers who want a source that is closest to their own bone matrix. Not for vegetarians.
Calcium Amino Acid Chelates (*HVP): this form is calcium carbonate bonded (Chelated) to a form of amino acid complex such as whole rice concentrate or other grain source. This form is for customers who want the additional bioavailability of amino acids.
Calcium AEP: Another form of calcium endorsed by Dr. Hans Nieper who theorized that calcium would cross the cell membranes more readily when it was combined with phosphatidyl ethanolamine or Amino Ethanol Phosphate (AEP), a nutrient found in nerve sheaths. This highly specialized form is for very educated customers who are proponets of Hans Niepers theory.
So, which form is best?
Calcium, like cars, comes in a variety of forms. Isn’t it wonderful that we have so many choices? The point is, there is no best one, there are only individual choices. Although we have our favorites, taking a calcium supplement, regardless of which one it is, should:
Our primary concern when choosing a calcium supplement should be to provide our body with the right amount of calcium daily so that our skeleton and teeth can maintain proper mineralization and strength as the cells continuously break down and rebuild. The type of calcium complex we prefer is entirely up to us.
*HVP = Hydrolyzed Vegetable Protein
Triple Boron - Activate the Bone-Building Basics
September 19, 2006 06:15 PM
March 27, 2006 06:23 PM
If there’s one truth to be told about the natural products industry, it is this. We will never have a shortage of companies claiming to be the best. It happens so often in fact, that distinguishing the quality from the questionable has become an exhausting task all in itself. After all, making claims is easy. What’s challenging, however, is supporting these claims with something concrete.
As no stranger to recognition, NOW takes pride in every honor that is bestowed upon us. And yes, over the past year, we have been blessed in many ways. Nothing, however, can match the sense of reward that comes from having our efforts, values and commitment to human wellness acknowledged by our peers, colleagues and valued customers. It is with the most sincere gratitude that we are once again able to share these with you.
Vitamin Retailer Magazine’s 2005 Vity Awards Every Spring, Vitamin Retailer Magazine recognizes the most outstanding dietary supplements, and honors the recipients with a Vity Award. The winning products are selected based on a number of criteria. This year, three NOW products were awarded 1st place honors.
The first was presented in recognition of our MSM 1000 mg. This marks the third consecutive year that we’ve watched our MSM excel in this category. Next was the award for Vitamin E, which went to our Natural Vitamin E-400 mixed tocopherol formula. Like MSM, this was also awarded 1st place st place for the third year in a row. Finally, the award for “Best Calcium”, which was given to our Calcium Citrate. With the calcium category regarded as one of the most competitive, taking top honors is an accomplishment that we’re all very proud of. Whole Foods Magazine Natural Choice Winner Best Sports Supplement
It should come as no surprise to anyone that there are literally hundreds of protein formulas available. When it was announced that our line of Whey proteins had earned the title of “Best Sports Supplement” from Whole Foods Magazine, we were truly honored to be selected as one of their Natural Choice winners.
Each year, Whole Foods Magazine evaluates hundreds of products, selecting only those that meet their demanding standards. Our Sports division has worked tirelessly to perfect our Whey proteins, and this award is a true testament to the efforts they have put forth. NOW is one of the very few companies that offers a line of 100% natural proteins, free of artifi cial sweeteners. Accordingly, this is an honor that we’re especially proud of. Nutrition Business Journal’s Lifetime Leadership Award, Elwood Richard
Nutrition Business Journal recently honored NOW founder Elwood Richard, with their prestigious Lifetime Leadership Award. Mr. Richard has been an active member of the natural products business since 1960 and is a strong advocate for both science and quality. He co-founded the NNFA standards committee, and sponsors industry organizations such as Citizens for Health, NNFA, ABC, AOAC and AHPA among others. His hard work, vision and commitment have inspired our entire organization
in supporting independent retailers, producing quality products and taking proactive measures towards environmental preservation.
Nutrition Business Journal’s Business Achievement Award, Environment of Sustainability In addition to the award presented to Elwood Richard, NOW was also the recipient of the NBJ Business Achievement Award for Environment of Sustainability. This honor is presented to businesses who have consistently participated in both internal and local initiatives to make positive environmental impacts. Notably, our recycling program has reduced waste output by over 50%. NOW FOODS Vitamins also conducts employee training programs, supports community conservation efforts and hosts volunteer workdays to plant vegetation, remove litter and control lakeside erosion in a local forest preserve. These actions have earned us a number of community service awards from several local recreation organizations. Finally, we help support environmental organizations, including The Nature Conservancy and World Wildlife Fund.
AOAC adopts NOW Glucosamine Method
NOW Foods’ glucosamine HPLC method has passed the AOAC’s 2-year validation process to become the fi rst offi cial method for testing the standards of this popular joint health ingredient. It was selected by the expert review panel in April of 2003 as the “best method for further laboratory validation”. It will be published in the Journal of AOAC International and become available to the industry this summer, 2005. “Having NOW’s method for glucosamine become the offi cial AOAC method is a testament to the expertise of our staff, our focus on the science, and our commitment to quality,” said Michael Lelah, technical director of NOW Foods.
DuPage County Forest Preserve District’s Shooting Star Award.
The DuPage County Forest Preserve District of Illinois recently presented NOW Foods their Shooting Star Award at their annual Forest Preserve District volunteer banquet. This award recognizes the long-term efforts that our entire organization has made in order to improve and support the quality of the East Branch Forest Preserve in Glendale Heights, IL. This is also the fi rst time that the District has given this award to a company. As the primary recipient, we look forward to furthering our environmental efforts.
Recapping our 2004 Achievements
Eight 1st Place Vity Awards, from Vitamin Retailer Magazine
United States Department of Commerce Excellence in Export Achievement Award
Nutrition Business Journal’s Effort on Behalf of Industry Award Consumerlab.com Top Rated Brand in Health Food Stores based on Customer Satisfaction Natural Nutritional Foods Association (NNFA) Crusader Award, Elwood Richard Vitamin Retailer Magazine Manufacturer of the Year (2003)
Benefits of Acetyl-L-Carnitine
February 12, 2006 01:55 PM
Potassium 99 Citrate 100ct
December 30, 2005 06:39 PM
Not Getting Enough Potassium?
Kal Potassium 99 Citrate now in 100 size bottles. Potassium provides support for maintaining normal healthy muscle function, nerve impulses, and helping to maintain healthy electrolyte balance.
Potassium Citrate is a natural form of the mineral found in foods. This Citrate form is throught to improve absorption and assimilation into the body.
OsteoBoron™ Fact Sheet
December 08, 2005 05:09 PM
OsteoBoron™ Fact SheetNeil E. Levin, CCN, DANLA 8/8/05
LIKELY USERS: People looking for joint support; People looking for bone density support; People who want to normalize Vitamin D levels
KEY INGREDIENTS: FruiteX-B™
STRUCTURE/FUNCTION CLAIMS: Boron is an important trace mineral for bone and joint health throughout life, as well as for the development and maintenance of healthy bone density. 1,2,4,6,8,9 NOW® OsteoBoron™ is a patented (US Patent # 5,962,049) complex of Boron and Fructose that is safe and more bioavailable than other forms of Boron. 3,7 NOW® OsteoBoron™ is a superior form of Boron that has been the subject of clinical studies demonstrating its efficacy in the support of healthy joints. 7,10 NOW® OsteoBoron™ has also been shown to be safer than other Boron supplements. 3,7
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES:
FruiteX-B™ is a patented ingredient that contains boron in a form that is chemically identical to the natural plant forms of boron found in food (Calcium Fructoborate). In human and animal studies this patented form of boron, taken at an amount equal or equivalent to 6 mg. per day, improved bone ash (bone minerals) and Vitamin D status in Vitamin D deficient subjects. In human studies, measurements of joint discomfort were dramatically reduced when taking this dosage for about 2 months. The dose used in most of these studies was equivalent to 2 capsules a day of NOW® OsteoBoron™, a form that has been shown to be biologically more beneficial than other forms of boron.11
SERVING SIZE & HOW TO TAKE IT: One vegetarian capsule twice a day, preferably at separate meals. This dose can be doubled for people with more severe deficiencies, though a physician should normally be consulted in such cases.
COMPLEMENTARY PRODUCTS: Vitamin D, Calcium, Magnesium, copper, Silica/silicon, natural sources of phytoestrogens (plant sourced), Ipriflavone, Bone Strength or Bone Calcium formulas
SPECIFIC: Please note any supplements currently consumed which may also contain boron, such as multiple mineral or multiple vitamin formulas, and cut your serving size of NOW® OsteoBoron™ to compensate. People who eat a lot of produce, fruit and nuts may also get a substantial amount from their food and may want to reduce their servings of NOW® OsteoBoron™ accordingly. NOW® OsteoBoron™ is safer (has less toxicity) than boron Citrate. Boron may buffer body levels of estrogen, so women at risk from high estrogen should consult a physician before using NOW® OsteoBoron™, even though this problem has not been noted for food source borons.
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Shils ME, Olson JA, Shike M (eds.) (1994) Modern Nutrition in Health and Disease, Eighth Edition. Chapters 20-26, 28, 30. Lea & Febiger Philadelphia.
TMG Fact Sheet
December 07, 2005 02:13 PM
TMG Fact SheetNeil E. Levin, CCN, DANLA 03/07/05
LIKELY USERS: People with high homocysteine levels; People with risks of developing Alzheimer’s Disease; People needing greater metabolism of fats; People with liver detoxification challenges; People consuming alcohol KEY INGREDIENTS: TMG is composed of three methyl groups attached to a glycine atom. It can “donate” methyl groups.
MAIN PRODUCT FEATURES: TMG is a metabolite of the B vitamin family product called Choline. Choline has 4 methyl groups, TMG has 3 and DMG has 2. These substances plus Folic acid, Vitamin B-12 and SAM-e are all methyl donors. Methyl donors can contribute methyl groups to biological processes such as liver function, detoxification and cellular replication (production of new cells). Methylation protects the kidneys and stimulates production of the fat-transporting molecule l-carnitine.
TMG helps the liver metabolize fats, preventing the accumulation of fats in the liver. It also helps to detoxify chemicals in the liver, while protecting the liver from being damaged by those chemicals.
Methylation with TMG helps to convert the dangerous, inflammatory chemical homocysteine into the amino acid methionine. TMG may lower homocysteine when B-6, B-12 and folic acid cannot.
ADDITIONAL PRODUCT INFORMATION: TMG is also known as Betaine and is a component of Betaine hydrochloride (Betaine HCl), a stomach acid supplement that is very acidic. But Betaine HCl is not used in the same way as TMG. TMG is not highly acidic and will not supplement low stomach acid.
TMG may be useful for autistic children, along with B-6 and magnesium. It may also be useful in strengthening the body’s immune response against pathogenic bacteria. There is very preliminary evidence that TMG and methyl donors may help against some forms of seizures.
DMG has been used as a sports supplement. TMG is 50% more effective than DMG in any application where the methyl groups are useful. Otherwise, they can used interchangeably.
SERVING SIZE & HOW TO TAKE IT: One serving per day, or up to 6,000 mg., as needed.
COMPLEMENTARY PRODUCTS: SAM-e, Milk Thistle (Silymarin), Dr. Verghese’s Liver Detoxifier & Regenerator, Antioxidants, NAC, Homocysteine Regulators, D-Flame, Detox Support
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement.
People with Parkinson’s or taking L-dopa should not use methyl donors like TMG without a physician’s specific approval and supervision. There are no other known drug interactions with TMG.
This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This is not an official publication by any company, nor has this information been screened or approved by the FDA or any private company.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. Review. PMID: 15321791
Barak AJ, Tuma DJ. Betaine, metabolic by-product or vital methylating agent? Life Sci 1983;32:771-4 [review].
Benson R, Crowell B, Hill B, et al. The effects of L-dopa on the activity of methionine adenosyltransferase: relevance to L-dopa therapy and tolerance. Neurochem Res 1993;18:325–30.
Chambers ST. Betaines: their significance for bacteria and the renal tract. Clin Sci 1995;88:25-7 [review].
Charlton CG, Crowell B Jr. Parkinson’s disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423–31.
Charlton CG, Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol 1994;9:149–61.
Cheng H, Gomes-Trolin C, Aquilonius SM, et al. Levels of L-methionine S-adenosyltransferase activity in erythrocytes and concentrations of S-adenosylmethionine and S-adenosylhomocysteine in whole blood of patients with Parkinson’s disease. Exp Neurol 1997;145:580–5.
Crowell BG Jr, Benson R, Shockley D, Charlton CG. S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson’s disease-like symptoms. Behav Neural Biol 1993;59:186–93.
Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].
Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol. 2004;51(2):405-13. Review. PMID: 15218538 Gahl WA, Bernardini I, Chen S, et al. The effect of oral betaine on vertebral body bone density in pyridoxine-non-responsive homocystinuria. J Inherit Metab Dis 1988;11:291-8.
Olthof MR, van Vliet T, Boelsma E, Verhoef P. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003 Dec;133(12):4135-8. PMID: 14652361
Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab. 2005 Feb;6(1):15-22. PMID: 15720203
Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr. 2002 Nov;76(5):961-7. PMID: 12399266
Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].
van Guldener C, Janssen MJ, de Meer K, et al. Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients. J Intern Med 1999;245:175-83.
Wendel U, Bremer HJ. Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency. Eur J Pediatr 1984;142:147-50.
Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria—the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983;309:448-53.
Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients. Metabolism. 1985 Dec;34(12):1115-21. PMID: 3934499
Babucke G, Sarre B. Clinical experience with betain Citrate. Med Klin 1973;68:1109-13 [in German].
Barak AJ, Beckenhauer HC, Badakhsh S, Tuma DJ. The effect of betaine in reversing alcoholic steatosis. Alcohol Clin Exp Res 1997;21:1100-2.
Barak AJ, Beckenhauer HC, Matti J, Tuma DJ. Dietary betaine promotes generation of hepatic S-adenosylmethioine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res 1993;17:552-5.
Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996;13:395-8 [review]. PMID: 8836329
Freed WJ. Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine. Pharmacol Biochem Behav. 1985 Apr;22(4):641-3. PMID: 2581277
Junnila M, Barak AJ, Beckenhauer HC, Rahko T. Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats. Vet Hum Toxicol 1998;40:263-6.
Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May;124(5):1488-99. PMID: 12730887
Kettunen H, Tiihonen K, Peuranen S, Saarinen MT, Remus JC. Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidia-infected broiler chicks. Comp Biochem Physiol A Mol Integr Physiol. 2001 Nov;130(4):759-69. PMID: 11691612
Kim SK, Kim YC, Kim YC. Effects of singly administered betaine on hepatotoxicity of chloroform in mice. Food Chem Toxicol 1998;36:655-61.
McCarty MF. Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy. Med Hypotheses. 2000 Sep;55(3):189-94. PMID: 10985907
Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol 1998;44:249-55.
Poschl G, Stickel F, Wang XD, Seitz HK. Alcohol and cancer: genetic and nutritional aspects. Proc Nutr Soc. 2004 Feb;63(1):65-71. Review. PMID: 15070439
Semmler F. Treatment of liver diseases, especially of fatty liver with betaine Citrate. Ther Ggw 1977;116:2113-24 [in German].
Zapadniuk VI, Panteleimonova TN. [Cholagogic effect of trimethylglycine in normal animals of different ages and in experimental atherosclerosis] Biull Eksp Biol Med. 1987 Jul;104(7):30-2. Russian. PMID: 3620644
Autism & Seizures:
Rimland B. Seizures, Vitamin B6, DMG, and Sudden Speech. Autism Research Review International. 1996;10(2):1.
Roach ES, Carlin L. N,N-dimethylglycine for epilepsy. N Engl J Med. 1982;307:1081-82.
Vitamin B6/DMG. Letters to the Editor, Autism Research Interview International. 1994;8(2):6.
Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med. Apr1990;115(4):481-6.
Hoorn AJ. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res. 1989 Apr;222(4):343-50. PMID: 2468082
Benefits of Total Daily Formula
October 13, 2005 04:45 PM
Benefits of Total Daily Formula
All fruits and vegetables contain carotenes, the plant pigments responsible for the rich variety of colors we enjoy in the natural world. Beta carotene is the most familiar member of the carotene family. But beta carotene never exists by itself; it is always found with other carotenes in foods. We need more than just beta carotene alone. Carotenes are powerful antioxidants, which means they help reduce the body's free radical burden. Research suggests that carotenes work as a team to keep us healthy.5 Total Daily Formula provides beta carotene, alpha carotene, lutein, lycopene, zeaxanthin and cryptoxanthin from natural sources such as algal extracts, carrot oil, marigold and tomatoes (Caromix®).
Total Daily Formula uses only corn-free vitamin C (ascorbic acid). The full daily intake of 6 tablets provides an exceptionally generous 800 mg of vitamin C.
Total Daily Formula supplies ample amounts of all essential B vitamins. Vitamin B3 is given as niacin plus an extra helping of niacinamide, the non-flush form of this important vitamin. The body uses pantothenic acid (vitamin B5) to deal with stress, so the formula provides 150 mg, which is 15 times the RDA. Vitamin B6 is another B vitamin people may run short of, so 60 mg -- 30 times the RDA -- is supplied. The formula contains 800 mcg of folic acid, the vitamin now recognized by the FDA as essential for prevention of neural tube defects in unborn babies. Folic acid also helps prevent accumulation in the body of homocysteine, a metabolite of the amino acid methionine.6 A high blood homocysteine level is now considered to be a risk factor for heart disease.7
Flavonoids, also known as "bioflavonoids." are plant pigments widely distributed throughout the plant kingdom.8 Previously known as "Vitamin P," because they help reduce capillary permeability (leakiness) flavonoids are now regarded as "semi-essential" non-vitamin nutrients that benefit health in a variety of ways.9 In addition to maintaining the structure of blood vessels, flavonoids function as versatile antioxidants. Flavonoids protect vitamin C from destruction by free-radicals, helping to preserve the body's vitamin C supply.10 Total Daily Formula provides 100 mg of pure flavonoids from 112 mg of citrus extract.
Three superior sources of Calcium
Total Daily Formula contains three of the best absorbed and most effective forms of calcium available. MCHC (microcrystalline hydroxyapatite concentrate) is a naturally-derived compound composed of calcium, plus all the minerals and organic factors in living bone tissue. MCHC has been clinically shown to benefit bone health.11 Calcium Citrate malate is a very well-absorbed form of supplemental calcium shown in recent research to be helpful for postmenopausal women.12,13 Calcium glycinate is chelated with the amino acid glycine, one of the most efficient mineral carriers for effective absorption.14,15
Magnesium is essential for strong bones and healthy hearts. This versatile mineral also regulates nerve function, keeps muscles relaxed and coordinates activity of over 300 enzymes in the body.16 Total Daily Formula contains 100 percent magnesium glycinate for exceptional absorption and gentleness on the intestinal tract.17 Magnesium glycinate has been clinically tested on people with severe malabsorption with excellent results.18
Total Daily Formula provides - in addition to zinc, chromium, selenium and iodine - vanadium and molybdenum. Vanadium helps maintain normal blood sugar.19 Molybdenum works as a co-factor for enzymes that help detoxify and eliminate foreign substances from the body.20
Bioperine® for Enhanced Absorption
Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. 21 Betaine HCL - supplies HCL (hydrochloric acid) to assist digestion. All natural tablet coating made of vegetable concentrate and beta carotene.
2. Morgan, K.J. et. al. Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition. 1985;4:195-206.
3. Lakschmanan, F.L., Rao, R.B., Kim, W.W., Kelsay, J.L. Magnesium intakes, balances and blood levels of adults consuming self-selected diets. American Journal of Clinical Nutrition 1984;40:1380-89.
4. Mertz, W. The Essential Trace Elements. Fed. Proc. 1970;29:1482.
5. Perry, G. Byers, T. Dietary carotenes, vitamin C and vitamin E as protective antioxidants in human cancers. Annu. Rev. Nutr. 1992;12:139-59.
6. Landgren, F., et. al. Plasma homocysteine in acute myocardial infarction: Homocysteine-lowering effect of folic acid. J Int Med 1995;237:381-88.
7. Clarke, R., et. al. Hyperhomocysteinemia: an independent risk factor for vascular disease. New Eng J Med 1991;324:1149-55. 8. Havsteen, B. Flavonoids, a class of natural compounds of high pharmacological potency. Biochemical Pharmacology 32(7):1141-48.
9. Middleton, E. The flavonoids. TIPS 1984; 5:335-38.
10. Roger, C.R. The nutritional incidence of flavonoids: some physiological and metabolic considerations. Experientia 44(9):725-804.
11. Dixon, A. St. J. Non-hormonal treatment of osteoporosis. British Medical Journal 1983;286(6370):999-1000.
12. Smith, K.T. et. al. Calcium Absorption from a new calcium delivery system (CCM). Calcif Tissue Int 1987;41:351-352.
13. Dawson-Hughes, B. et. al. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. New England Journal of Medicine 1990 Sep 27;323(13):878-883.
14. Albion Research Notes Vol. 4, No. 1, ©Albion Laboratories Jan,1995.
15. Ashmead, H.D. Intestinal Absorption of Metal Ions and Chelate, Springfield: Charles C Thomas, ©1985.
16. Wester, P.O., Dyckner, T. The importance of the magnesium ion. Magnesium deficiency-symptomatology and occurrence. Acta Med Scand 1992; (Suppl) 661:3-4.
17. Albion Research Notes Vol. 3, No. 1, ©Albion Laboratories, Feb 1994.
18. Schutte, S., et. al. Bioavailability of Mg diglycinate vs MgO in patients with ileal resections. Abstract 115, AJCN 1992;56(4).
19. Cohen, N. et. al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J. Clin Invest 1995; 95:2501-09.
20. Sardesi, V.M. Molybdenum: An essential trace mineral element. Nutr Clin Pract 1993; 8:277-81.
21. Bioperine® - Nature's Bioavailability Enhancing Thermo-nutrient. Executive Summary' 1996; Sabinsa Corporation, Piscataway, N.J.
June 25, 2005 08:13 PM
1 a. The Surgeon General’s “Nutrition and Health Report.” b. The Centers for Disease Control and Prevention’s “National Health and Examination Survey (NHANES III)” c. The National Academy of Science’s. Diet and Health Report: Health Promotion and Disease Objectives (DHHS Publication No. (PHS) 91-50213, Washington, DC: US Government Printing Office, 1990). e. Dietary Guidelines for Americans. 2 Rolls BJ. Carbohydrates, fats, and satiety. Am J Clin Nutr 1995; 61(4 Suppl):960S-967S. 3 McDowell MA, Briefel RR, Alaimo K, et al. Energy and macronutrient intakes of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1:1988-91. Advance data from vital and health statistics of the Centers for Disease Control and Prevention; No. 255. Hyattsville, Maryland: National Center for Health Statistics; 1994. 4 Center for Science in the Public Interest and McDonald’s Nutrition and You—A guide to Healthy Eating at McDonald’s: McDonald’s Corp,1991. 5 Bray GA. Appetite Control in Adults. In: Fernstrom JD, Miller GD eds. Appetite and Body Weight Regulation. Boca Raton: CRC Press, 1994:1-92. 6 Michnovicz JJ. How to Reduce Your Risk of Breast Cancer. New York: Warner Book Inc. 1994:54. 7 Carcinogens and Anticarcinogens in the Human Diet. National Research Council Report, National Academy of Sciences, 15 Feb. 1996. 8 Van Tallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979:32: 2723-33. 9 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:273. 10 Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16A-hydroxyestrone to estradiol in human breast concer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1988:85;7831-5. 11 Colditz GA. Epidemiology of breast cancer. Findings from the nurses’ health study. Cancer1993;714:1480-9. 12 Hennen WJ. Breast Cancer Risk Reduction. The effects of supplementation with dietary indoles. Unpublished report 1992. 13 Deslypere BJ. Obesity and cancer. Metabolism 1995;44(93):24-7. 14 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:281. 15 Whittemore AS, Kolonel LN, John M. Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst 1995;87(9):629-31. 16 Key T. Risk factors for prostate cancer. Cancer Survivor 1995;23:63- 77. 17 Kondo Y, Homma Y, Aso Y, Kakizoe T. Promotional effects of twogeneration exposure to a high-fat diet on prostate carcinogenisis in ACI/Seg mice. Cancer Res 1994;54(23):6129-32. 18 Wang Y, Corr JG, Taler HT, Tao Y, Fair WR, Heston WD. Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet. J Natl Cancer Inst. 1995;87(19):1456-62. 19 Nixon DW. Cancer prevention clinical trials. In-Vivo 1994;8(5):713-6. 20 Key T. Micronutrients and cancer aetiology: the epidmiological evidence. Proceed Nutr Soc 1994;53(3):605-14. 21 Gorbach SL, Goldin BR. The intestinal microflora and the colon cancer connection. Reviews of Infectious Diseases 1990;12(Suppl 2):S252-61. 22 Shrapnel WS, Calvert GD, Nestel PJ, Truswell AS. Diet and coronary heart disease. The National Heart Foundation of Australia. Med J Australia. 1995;156(Suppl):S9-S16. 23 Ellis JL, Campos-Outcalt D. Cardiovascular disease risk factors in native Americans: a literature review. Am. J. Preventive Med 1994;10(5):295-307. 24 DiBianco R. The changing syndrome of heart failure: an annotated review as we approach the 21st century. J. Hypertension 1994; 12(4 Suppl):S73- S87. 25 Van Itallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979;32(suppl):2723-33. 26 Kestin M, Moss R, Clifton PM, Nestel PJ. Comparative effects of three cereal brans on plasma lipids, blood pressure and glucose metabolism in mildly hyper-cholesterolemic men. Am J Clin Nutr 1990;52(4):661-6. 27 Story JA. Dietary fiber and lipid metabolism. In: Spiller GA, Kay RM. eds. Medical Aspects of Dietary Fiber. Penun Medical; New York, 1980, p.138. 28 Stein PP, Black HR. The role of diet in the genesis and treatment of hypertension. Med. Clin. North America. 1993;77(4):831-47. 29 Olin JW. Antihypertensive treatment in patients with peripheral vascular disease. Cleve. Clin. J. Medicine. 1994;61(5):337-44. 30 Tinker LF. Diabetes Mellitus—a priority health care issue for women. J. Am. Dietetic Association. 1994;94(9):976-85. 31 Gaspard UJ, Gottal JM, van den Brule FA. Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas. 1995;21(3):71-8. 32 Coordt MC, Ruhe RC, McDonald RB. Aging and insulin secretion. Proc. Soc. Exp. Biology and Medicine. 1995;209(3):213-22. 33 Felber JP. From Obesity to Diabetes. Pathophysiological Considerations. Int. Journal of Obesity 1992;16:937-952. 34 Gillum RF. The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes, and cardiovascular risk factors in men and women age 18-79. J Chronic Diseases 1987;40:421-8. 35 Haffner SM, Stern MP, Hazuda HP, et al. Role of obesity and fat distribution in non-insulin-dependent diabetes mellits in Mexican Americans and non- Hispanic whites. Diabetes Care 1986;9:153-61. 36 Bonadonna RC, deFronzo RA. Glucose metabolism in obesity and type 2 diabetes. Diabetes and Metabolism. 1991;17(1 Pt. 2):12-35. 37 Shoemaker JK, Bonen A. Vascular actions of insulin in health and disease. Canadian J. of Applied Physiology. 1995;20(2):127-54. 38 Resnick LM. Ionic Basis of Hypertension, Insulin Resistaince, Vascular Disease, and Related Disorders. The Mechanism of ‘Syndrome X’. Am. J. Hypertension. 1993;6(suppl):123S-134S. 39 Trautwein EA. Dietetic influences on the formation and prevention of cholesterol gallstones. Z. Ernahrugswiss. 1994;33(1):2-15. 40 Cicuttini FM, Spector TD. Osteoarthritis in the aged. Epidemiological issues and optimal management. Drugs and Aging. 1995;6(5):409-20. 41 Melnyk MG, Wienstein E. Preventing obesity in black women by targeting adolescents: a literature review. J Am. Diet. Association. 1994;94(4):536-40. 42 Robinson BE, Gjerdingen Dk, Houge DR. Obesity: a move from traditional to more patient-oriented management. J. Am. Board of Family Practice. 1995;8(2):99-108. 43 Dulloo AG, Miller DS. Reversal of Obesity in the Genetically Obese fa/fa Zucker Rat with an Ehpedrine/Methylxanthines Thermogenic Mixture. J. Nutrition. 1987;117:383-9. 44 Dulloo AG, Miller DS. The thermogenic properties of ephedrin/methylxanthine mixtures: animal studies. Am J Clinical Nutr. 1986;43:388-394. 45 Richelsen B. Health risks of obesity. Significance of the regional distri-bution of adipose tissue. Ugeskr. Laeger. 1991;153(13):908-13. 46 Lissner L, Heitmann BL. Dietary fat and obesity: Evidence from epidemiology. European J. Clinical Nutrition. 1995;49(2):79-90. 47 Lissner L, Heitmann BL. The dietary fat: Carbohydrate ratio in relation to body weight, Current Opinion in Lipidology. 1995;6(1):8-13. 48 Ravussin E. Energy metabolism in obesity. Studies in the Pima Indians. Diabetes Care. 1993;16(1):232-8. 49 O’Dea K. Westernisation, insulin resistance and diabetes in Australian aborigines. Med J. Australia. 1991;155(4):258-64. 50 Bailey C. Fit or Fat . Houghton Mifflen, Boston, 1991. 51 McCarty MF. Optimizing Exercise for Fat Loss. Unpublished report. 52 Weinsier RL, Schutz Y, Bracco D. Reexamination of the relationship of resting metabolic rate and fat-free mass and the the metabolically active components of fat-free mass in humans. Am. J. Clinical Nutrition. 1992;55(4):790-4. 53 Evans WJ. Exercise, nutrition and aging. J. Nutrition. 1992;122(3 suppl):796-801. 54 Schlicker SA, Borra ST, Regan C. The weight and fitness status of United States children. Nutrition Reviews. 1994;52(1):11-7. 55 Raben A, Jensen ND, Marckmann P, Sandstrom B and Astrup A. Spontaeous weight loss during 11 weeks’ ad libitum intake of a low fat/high fiber diet in young, normal weight subjects. Stockholm Press. 1995;916-23. 56 Blundell JE, Cotton JR, Delargy H, Green S, Greenough A, King NA, Lawton, CL. The fat paradox: fat-induced satiety signals versus high fat overconsumption. Short Communication 1995:832-835. 57 Reinhold RB. Late results of gastric bypass surgery for morbid obesity. J Am Coll Nutr 1994;13(4):307-8. 58 McCredie M, Coates M Grulich A. Cancer incidence in migrants to New South Wales (Australia) from the Middle East, 1972-1991. Cancer Causes Control 1994:5(5):414-21. 59 Schiff ER, Dietschy JM. Steatorrhea Associated with Disordered Bile Acid Metabolism. Am. J. Digestive Diseases. 1969;14(6) 60 Nauss JL , Thompson JL and Nagyvary J. The binding of micellar lipids to Chitosan. Lipids. 1983;18(10):714-19. 61 Braconnot H, Sue la natrue ces champignons. Ann Chim Phys 1811;79:265. 62 Odier A. Memoire sur la composition chemique des parties cornees des insectes. Mem Soc Hist Nat Paris 1823;1:29. 63 Johnson EL, Peniston QP. Utilization of shellfish waste for chitin and Chitosan production. Chp 19 In: Chemistry and Biochemistry of Marine Food Products. Martin RE, Flick GJ, Hebard CE and Ward DR (eds.) 1982. p.415-. AVI Publishing Co., Westport, CT. 64 Shahram H. Seafood waste: the potential for industrial use. Kem Kemi 1992;19(3),256-8. 65 Rouget C. Des substances amylacees dans le tissue des animux, specialement les Articules (Chitine). Compt Rend 1859;48:792. Commission on Natural Health Products. 1995 67 Peniston QP and Johnson EL. Method for Treating an Aqueous Medium with Chitosan and Derivatives of Chitin to Remove an Impurity. US Patent 3,533,940. Oct. 30:1970. 68 Poly-D-Glucosamine (Chitosan); Exemption from the Requirement of a Tolerance. Federal Register. 1995;60(75):19523-4. Rules and Regulations. Environmental Protection Agency 40 CFR Part 180. April, 19, 1995. 69 Arul J. “Use of Chitosan films to retard post-harvest spoilage of fruits and vegetables,” Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 70 Karlsen J, Skaugrud O. “Excipient properties of Chitosan,” Manufacturing Chemist. 1991;62:18-9. 71 Winterowd JG, Sandford PA. Chitin and Chitosan. In: Food Polysaccharides and their Applications. Ed: Stephen AM. Marcel Dekker 1995. 72 Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 73 Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 74 Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 75 Zikakis, JP. Chitin, Chitosan and Related Enzymes. Academic Press, Inc. 1984. 76 Abelin J and Lassus A. Fat binder as a weight reducer in patients with moderate obesity. ARS Medicina, Helsinki, Aug- October, 1994. 77 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Increasing effect of a Chitosan and ascorbic acid mixture on fecal dietary fat excretion. Biosci Biotech Biochem 1994;58(9):1617-20. 78 Maezaki Y, Tsuji K, Nakagawa Y, et al. Hypocholesterolemic effect of Chitosan in adult males. Biosci Biotchnol Biochem1993;57(9):1439-44. 79 Kobayashi T, Otsuka S, Yugari Y. Effect of Chitosan on serum and liver cholesterol levels in cholesterol-fed rats. Nutritional Rep. Int., 1979;19(3):327-34. 80 Sugano M, Fujikawa T, Hiratsuji Y, Hasegawa Y. Hypocholesterolemic effects of Chitosan in cholesterol-fed rats. Nutr Rep. Int. 1978;18(5):531-7. 81 Vahouny G, Satchanandam S, Cassidy M, Lightfoot F, Furda I. Comparative effects of Chitosan and cholestryramine on lymphatic absorption of lipids in the rat. Am J Clin Nutr, 1983;38(2):278-84 82 Suzuki S, Suzuki M, Katayama H. Chitin and Chitosan oligomers as hypolipemics and formulations containing them. Jpn. Kokai Tokkyo Koho JP 63 41,422 [88,422] 22 Feb1988. 83 Ikeda I, Tomari Y, Sugano M. Interrelated effects of dietary fiber on lymphatic cholesterol and triglyceride absorption in rats. J Nutr 1989;119(10):1383- 7. 84 LeHoux JG and Grondin F. Some effects of Chitosan on liver function in the rat. Endocrinology. 1993;132(3):1078-84. 85 Fradet G, Brister S, Mulder D, Lough J, Averbach BL. “Evaluation of Chitosan as a New Hemostatic Agent: In Vitro and In Vivo Experiments In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 86 Malette W, Quigley H, Gaines R, Johnson N, Rainer WG. Chitosan A New Hemostatic. Annals of Thorasic Surgery. 1983;36:55. 87 Malette W, Quigley H, Adickes ED. Chitosan effect in Vascular Surgery, Tissue Culture and Tissue Regeneration. In R Muzzarelli, C Jeuniaux, GW Gooday, Eds: Chitin in Nature and Technology. Plenum Press, New York. 1986. 88 Okamoto Y, Tomita T, Minami S, et al. Effects of Chitosan on experimental abscess with Staphylococcus aureus in dogs. J. Vet. Med., 1995;57(4):765-7. 89 Klokkevold PR, Lew DS, Ellis DG, Bertolami CN. Effect of Chitosan on lingual hemostasis in rabbits. Journal of Oral-Maxillofac-Surg, 1991;Aug. 49(8):858-63. 89 Surgery, Tissue Culture and Tissue Regeneration. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 90 Hiroshi S, Makoto K, Shoji A, Yoshikazu S. Antibacterial fiber blended with Chitosan. Sixth International Conference on Chitin and Chitosan. Sea Fisheries Institute, Gdynia, Poland. August 1994;16-19. 91 Shimai Y, Tsukuda K, Seino H. Antiacne preparations containing chitin, Chitosan or their partial degradation products. Jpn. Kikai Tokkyo Koho JP 04,288,017 [92,288,017] 13 Oct 1992. 92 Suzuki K, Okawa Y, Suzuki S, Suzuki M. Candidacidal effect of peritoneal exudate cells in mice administered with chitin or Chitosan: the role of serine protease in the mechanism of oxygen-independent candidacidal effect. Microbiol Immunol. 1987;31(4):375-9. 93 Sawada G, Akaha Y, Naito H, Fujita M. Synergistic food preservatives containing organic acids, Chitosan and citrus seed extracts. Jpn, Kokai Kokkyo Koho JP 04 27,373 [92 27,373] 30 Jan 1992. 94 Min H-K, Hatai K, Bai S. Some inhibitory effects of Chitosan on fishpathogenic oomycete, Saprolegnia parasitic. Gyobyo Kenkyu, 1994;29(2):73-4. 95 Nelson JL, Alexander JW, Gianotti L, Chalk CL, Pyles T. The influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutr 1994;10(1):32-6. 96 Ochiai Y, Kanazawa Y. Chitosan as virucide. Jpn Kokai Tokkyo Koho 79 41,326. 97 Hillyard IW, Doczi J, Kiernan. Antacid and antiulcer properties of the polysaccharide Chitosan in the rat. Proc Soc Expl Biol Med 1964; 115:1108-1112. 98 Shibasaki K, Sano H, MatsukuboT, Takaesu Y. pH response of human dental plaque to chewing gum supplemented with low molecular Chitosan. Bull- Tokyo-Dent-Coll, 1994:35(2): 61-6. 99 Kato H, Okuda H. Chitosan as antihypertensive. Jpn. Kikoi Tokyo Koho JP 06 56,674 [94 56,674] 100 Kato H, Taguchi T. Mechanism of the rise in blood pressure by sodium chloride and decrease effect of Chitosan on blood pressure. Baiosaiensu to Indasutori 1993;51(12):987-8. 101 Muzzarelli R, Biagini G, Pugnaoni A, Filippini O, Baldassarre V, Castaldini C, and Rizzoli C. Reconstruction of Periodontal Tissue with Chitosan. Biomaterials. 1989;10:598-603. 102 Sapelli P, Baldassarre V, Muzzarelli R, Emanuelli M. Chitosan in Dentistry. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 103 Borah G, Scott G, Wortham K. Bone induction by Chitosan in endochrondral bones of the extremities. In Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 104 Ito F. Role of Chitosan as a supplementary food for osteoporosis. Gekkan Fudo Kemikaru, 1995;11(2):39-44. 105 Nakamura S, Yoshioka T, hamada S, Kimura I. Chitosan for enhancement of bioavailability of calcium. Jpn. Kokai Tokkyo Koho JP 07 194,316 [95 194,316] 01 Aug 1995. 106 Maekawa A, Wada M. Food Containing chitin or its derivatives for reduction of blood and urine uric acid. Jpn. Kokai Tokkyo Koho JP 03 280,852 [91 280,852], 11 Dec 1991. 107 Weisberg M, Gubner R. Compositions for oral administration comprising Chitosan and a pharmaceutically acceptable carrier. Antacid preparations for alleviating gastric hyperacidity. U.S. patent 3257275 108 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Mechanism for the inhibition of fat digestion by Chitosan and for the synergistic effect of ascorbate. Biosci Biotech Biochem1995;59(5):786-90. 109 McCausland CW. Fat Binding Properties of Chitosan as Compared to Other Dietary Fibers. Private communication. 24 Jan1995. 110 Deuchi K, Kanauchi O, Imasato Y, Kobayashi E. Biosci Biotech Biochem. 1994:58,1613-6. 111 Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 1989;119(8):1100-6. 112 Weil A, M.D. Natural Health Natural Medicine: Boston: Houghton Mifflin, 1990:182. 113 Chen Y-H, Riby Y, Srivastava P, Bartholomew J, Denison M, Bjeldanes L. Regualtion of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells. J Biol Chem 1995;270(38):22548-55. 114 Intestinal Absorption of metal ions and chelates. Ashmead HD, Graff DJ, Ashmead HH. Charles C Thomas, Springfield, IL 1985. 115 Nutrient Interactions. Bodwell CE, Erdman JW Jr. Marcel Dekker New York 1988. 116 Heleniak EP, Aston B. Prostaglandins, Brown Fat and Weight Loss. Medical Hypotheses 1989;28:13-33. 117 Connor WE, DeFrancesco CA, Connor SL. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann NY Acad Sci 1993;683:16-34. 118 Conte AA. A non-prescription alternative in weight reduction therapy. The Bariatrician Summer 1993:17-19. 119 McCarty MF. Inhibition of Citrate lyase may aid aerobic endurance. Unpublished manuscript. 120 Bray GA. Weight homeostasis. Annual Rev Med 1991;42:205-216. 121 Dulloo AG, Miller DS. The thermogenic properties of Ephedrin/Methylxanthine mixtures: Human studies. Intl J Obesity 986;10:467-481. 122 Arai K, Kinumaki T, Fujita, T. Bulletin Tokai Regional Fisheries Res Lab. 1968;No. 56. 123 Bough WA. Private communication. 124 Freidrich EJ, Gehan, EA, Rall DP, Schmidt LH, Skipper HE. Cancer Chemotherapy Reports 1966;50(4):219-244. 125 A Drovanti, AA Bignamini, AL Rovati. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebo-controlled double-blind investigation. Clinical Therapeutics 1980;3(4):260-272. 126 K Deuchi, O Kanauchi, M Shizukuishi, E Kobayashi. Continuous and massive intake of Chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet. Biosci. Biotech. Biochemistry. 1995;59(7):1211-6. 127 . BesChitin W in Chitin Wound Healing (video), Unitika Corporation, April 1992.
Heart Science - A Five-Tiered Approach to Heart Health ...
June 02, 2005 12:07 PM
Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available.
Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health
Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for
Energy Generators for An Energetic Organ
Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply.
There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently.
CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10
Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound.
Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21
HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells.
B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization.
The Dangers of Oxidized LDL Cholesterol
While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL.
When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse.
The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes.
Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol.
Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits:
The Regulating Trio
Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings.
Artery Lining Protectors
Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6
Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart.
The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care.
Source Naturals HEART SCIENCE™
Chem-Defense - Fight Chemical sensitivity ...
June 01, 2005 10:21 AM
CHEMICAL SENSITIVITY IS REAL.
COURTESY OF THE INDUSTRIAL REVOLUTION, OUR ENVIRONMENT HAS BECOME A STEW OF FOREIGN CHEMICALS. For some people suffering the malaise, lack of focus, and drained feeling associated with chemical sensitivities, home is the only sanctuary from this onslaught. For others, not even home is safe. We at Source Naturals take this threat very seriously. That’s why we created CHEM-DEFENSE.
Source Naturals’ CHEM-DEFENSE is a potent combination of Molybdenum, Glutathione, and Coenzymated B-2, nutrients which research has shown may help break down and dispel harmful chemicals from the body. And CHEM-DEFENSE is sublingual — it dissolves under the tongue so it goes directly into your bloodstream, where it can be delivered to your system, fast.
major problem has hit America in the late 20th century that is more far reaching than most people are aware — chemical sensitivity. In fact, some studies indicate that 1 out of 3 Americans may be afflicted with chemical sensitivities. In the past century, modern organic chemistry has synthesized and released into the world an estimated 300,000 xenobiotic (foreign to our normal biology) chemicals. The food processing and food growing industries put an approximate 10,000 xenobiotic chemicals into our food supply alone. These chemicals can be found in common items such as cleaning fluids, drycleaning compounds, glues, cigarette smoke, perfume, building materials and processed foods. Chemical sensitivity is the result of impairment or inadequacy of the body’s natural detoxification systems, allowing excessive levels of harmful, xenobiotic chemicals to accumulate in the body, and the results are often devastating. In sensitive people, artificial chemicals can cause an incredible range of problems: “fogginess” and lack of focus, emotional distress, fatigue, and more. The parts of the body that are most affected can vary from person to person. Some of the worst offenders are the aldehydes. The most infamous of these is formaldehyde (found in such widely used items as permanent press clothing, particle board, paints and upholsteries). The other common culprit is acetaldehyde (produced by Candida overgrowth or from alcohol consumption).
The Secret to CHEM-DEFENSE’S Power is Molybdenum
Fortunately, nature has provided the body with a special aldehyde detoxification pathway: an enzyme called aldehyde oxidase (ADO). ADO is activated by one of the coenzyme forms of Vitamin B2, Flavin Adenine Dinucleotide (FAD), and the trace mineral Molybdenum. Unfortunately, this enzymatic pathway can become impaired due to overexposure to foreign chemicals. In addition, aging, nutritional deficiencies, genetics and general poor health can greatly diminish the body’s production of these enzymes, causing a toxic buildup of aldehydes, leaving many individuals vulnerable. Current nutritional research has revealed that supplementing the diet with Molybdenum and Coenzyme B-2, both found in CHEM-DEFENSE, can increase levels of the important enzyme ADO, helping to dispel toxins from the body. A study published in the Townsend Letter for Doctors confirms the benefits of a sublingually administered 300 mcg dose (100 mcg three times a day) of Molybdenum. It was found that on the average, about 50-65% of the various symptoms of chemical sensitivity — including fogginess and other discomforts — were alleviated at least to some degree. Molybdenum is also important for several other enzymes, including xanthine oxidase, and most importantly, sulfite oxidase. Sulfite oxidase is responsible for breaking down sulfites, chemicals widely used as preservatives in wines, salad bars, produce, and other foods. Sulfites are a common culprit in chemical sensitivity reactions. In fact, by the 1980’s, it was conservatively estimated that 5,000,000 (five million) Americans were sensitive to sulfites and experienced discomfort upon ingestion. Sulfite oxidase is also important in the sulfation of various compounds, especially in the brain. This is particularly important, as the brain is often dramatically affected during bouts of chemical sensitivity. According to the Nutrition Desk Reference, the amount of Molybdenum required daily for people is 100 mcg to 500 mcg. It also states that the amount of Molybdenum in food can vary tremendously, depending on crop soil levels. Low levels are not at all uncommon, and they are lessened even further by commercial farming practices that utilize synthetic fertilizers which do not put Molybdenum back into the soil. The result? The typical American diet does not provide adequate Molybdenum. The form of Molybdenum included in CHEM-DEFENSE is Molybdenum Aspartate-Citrate, Molybdenum bound to the cellular metabolites Aspartic Acid and Citric Acid. This has been shown to be the most bioactive form available by experts in mineral metabolism.
Glutathione in its Most Bioavailable Form
Ultimately, the one organ that must cope with and attempt to relieve the body of toxic chemicals is the liver, often referred to by nutritionists as “the body’s most overburdened organ.” To accomplish this, the liver must rely heavily on Glutathione, a tripeptide (three amino acids bound together). The Glutathione in CHEM-DEFENSE will help the liver to produce adequate levels of the important enzymes glutathione peroxidase (GSHpx) and glutathione S-transferase (GSH-S), enzymes that are essential for breaking down and disposing of foreign chemicals in the body. Glutathione peroxidase (GSHpx) helps to break down hydrogen peroxide, a medium-level toxin which is found in many xenobiotic chemicals. GSHpx also prevents cell damage caused by fatty acid oxidation, which threatens the integrity of cell membranes. Glutathione is very fragile. In fact, when taken orally, it is often destroyed by protein-digesting enzymes in the stomach. As CHEM-DEFENSE is in sublingual form, it bypasses the digestive process and goes straight into the bloodstream, allowing for maximum activity.
Coenzyme B2 — The “Recycling” Nutrient
Once Glutathione is used in the body for its detoxification functions, it becomes oxidized Glutathione, meaning it has been “used up.” Fortunately, the human body can “recycle” oxidized Glutathione and return it to its beneficial reduced (active) state. This process is made possible by a coenzyme form of Vitamin B2 (FAD), which is present in CHEM-DEFENSE.
Sublingual Delivery for Maximum Benefit
Many nutrients, when taken orally, are never completely absorbed into the bloodstream, or not absorbed at all! Because this formula is in sublingual form, the nutrients in CHEM-DEFENSE are absorbed directly into the bloodstream through the blood vessels under the tongue and in the cheeks, assuring maximum bioavailability and benefit. In America today, as foreign chemicals continue to be released into the environment on an uncontrolled basis, people continue to experience chemical sensitivities for which there appears to be no solution. Now there is. Source Naturals CHEM-DEFENSE combines the most bioavailable forms of key antioxidant nutrients that are not only powerful in and of themselves, but work together synergistically to address the problems associated with chemical sensitivities. As with all of their other products, Source Naturals has taken special care to create a product that is all natural, hypo-allergenic, and sugarfree. CHEM-DEFENSE sublingual is available in two delicious flavors — natural peppermint, and for people on homeopathic regimens who prefer an alternative to peppermint, natural orange flavor. Let’s face it — life in the modern world is a battle for your health. Arm yourself with a powerful weapon: Source Naturals CHEM-DEFENSE.
May 09, 2005 10:08 AM
Calm Child is a clinically derived herbal formula, specifically designed to support many body systems that are critical to the health and well-being of children. It is truly a multi-purpose herbal treasure, useful for supporting the health of the immune system in winter, enhancing digestive processes, and promoting restful sleep issues commonly experienced by most children. It also helps defend the system against the negative effects of stress, eases occasional restlessness, and promotes calm focused attention.
The Challenged Child
Difficulty in focusing and concentrating is one of the fastest growing problems for children today. This is a "new" problem, recognized as such over the last thirty years of the twentieth century. In the nineties, up to 5 percent or more of all school-age children were identified as having issues with focus (greater than 5 million children in 1995, over 25% higher than in 1985!). Since then, this number has continued to grow. Signs of the problem include the following and must be present for at least six months in more than one setting (home, school, etc.) especially before the age of seven: distractibility (inattention); inability to concentrate or focus; impulsivity (poor self-control); and excessive activity. Of course, measures of all of these are very subjective and are a part of the development of almost every child. Additionally, situations such as premature separation from parents, or unresolved emotional issues, or a family crisis, can cause children to withdraw or, conversely, act out due to an inability to appropriately express their feelings. Further, excessive and violent TV and computer games, lack of physical exercise, and poor diets can cause over-stimulation, internally and externally. Determining when such behavior is a problem is subject to interpretation. Too often, children are provided with a diagnosis before they are out of pre-school and are far too often prescribed pharmacological interventions such as amphetamines (Ritalin).
The Birth of Calm Child
My husband, Michael Tierra, originally formulated Calm Child for our own child, Chetan, then one year old, to address a wide array of potential childhood issues. His underlying intention was to use Calm Child for all children, based on his belief that most childhood emotional complaints are due to the unconscious pain of separation from the security and comfort of the womb. It was also based on the fact that historically, botanicals have been widely used to support the development of healthy children. Chamomile and lemon balm are perfectly suited for this purpose. Both are incredibly gentle-acting and deliciously fragrant botanicals that promote relaxation and calmness. Both also address underlying digestive imbalances that can give rise to occasional irritability and restlessness.
The Calm Child Formula
The herbs in Calm Child have a long history of use for calm focused attention in children: Lemon Balm: In his herbal of 1640, the renowned English medical botanist John Parkinson quoted Serapion the Younger (802-849) who said lemon balm is used "to cause the mind and heart to become merry...to strengthen the weakness of the spirits and heart, and to comfort them..." This belief in the comforting effects of lemon balm persisted and was repeated by Avicenna, who stated "it makes the heart merry and strengthens the vital spirit." In the 16th century, the renowned herbalist Nicholas Culpeper reported on the use of lemon balm for melancholy and sadness. Herbalists and midwives today continue to use lemon balm for the same purposes. Chamomile: Well-known in the nineteenth century, chamomile was used for crying, weepy children and to support calm digestion. Herbalists have long recognized a relationship between upset stomachs and restless children. Today, it is still widely used in homeopathy for babies' teething and children's clinginess. Other complementary ingredients in Calm Child include: jujube seeds (zizyphus), one of the most nourishing and relaxing nerve tonics used in Chinese herbalism; the incredibly nourishing berries of hawthorn and amla; the calming, aromatic, and digestive promoting effects of catnip, anise, clove, and long pepper; the legendary gotu kola for promoting mental well-being and attention; and the minerals magnesium (taurinate) and calcium (Citrate), both necessary for normal nerve and muscular function.
Works in Three Important Ways
Together these botanicals work in three important ways to promote calm focused attention in children. They: 1) promote a calm relaxed nervous system; 2) provide added nourishment which is essential for normal brain function; and 3) support a calm and healthy digestive system which is often an underlying cause of childhood restlessness.
Calm Child was developed more than 20 years ago and has been used by literally tens of thousands of children worldwide. In my own clinical practice, I have found Calm Child to have a wide range of uses. It is great as a wintertime supplement, to support normal digestion, promote relaxation and sleep, and perhaps most important, to cultivate a strong, centered, focused sense of mental and emotional well-being, specifically in children though many parents of active children have benefited from it as well. When it is given in conjunction with a diet that is low in refined sugars and food colorings and additives, parents report tremendous success in dealing with teething, occasional headaches and digestive imbalances, increasing attention in school, or helping their children cope with the stresses of day care.
For best results, herbs are always given in conjunction with diet and lifestyle recommendations. When using Calm Child, make sure the child is eating sufficient protein for his/her needs along with lots of cooked vegetables and some whole grains. Include some fruit, but keep fruit juices to a minimum as they contain too much simple sugar for children. Eliminate sugar, white flour products, foods with colors and preservatives, and caffeinated products as much as possible. Be sure to give plenty of water (many children never drink water but depend on juices or sodas instead!). Also, children inherently have much more energy than their parent and teacher handlers who try to make them sit still and focus on something that has little meaning to them. Make sure they get plenty of physical exercise to burn off some of the energy that teachers and parents have difficulty harnessing.