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NSAIDs vs. Curcumin: Which One Relieves Joint Pain Without Stopping Healing?   
Date:
September 14, 2026 11:22 AM
Comparative Analysis of NSAIDs versus Curcumin in Musculoskeletal Tissue RepairPrimary Biological Mechanisms and Pharmacological TargetsManaging soft tissue and joint injuries presents a persistent therapeutic challenge in musculoskeletal medicine. Acute inflammation triggers pain, localized swelling, and mechanical disability, which routinely drives patients toward pharmacological relief. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, celecoxib, and diclofenac have served as primary clinical interventions. While these synthetic agents effectively extinguish acute pain signals, Expanding cellular and clinical research indicates that their biochemical mechanism interrupts the fundamental repair cascades required for long-term connective tissue healing. In contrast, curcumin - a natural polyphenolic compound derived from the rhizomes of Curcuma longa (turmeric) - exhibits a distinct, multi-targeted regulatory profile that calms hyperactive inflammation while protecting the structural components of cartilage and tendon tissue.The functional divergence between these two compounds becomes clear when considering an intuitive mechanical analogy. Tissue trauma resembles damage to a commercial building, where initial inflammation functions as the construction and demolition crew tasked with clearing rubble, stabilizing the foundation, and laying down fresh structural framing. NSAIDs function like abruptly cutting electrical power to the entire work site: the noisy machinery stops instantly and the immediate disturbance ceases, but the construction workers lose the power necessary to clean the debris and erect permanent walls. Conversely, curcumin operates as an experienced site manager: it silences unnecessary chaos and prevents site vandalism while ensuring that the skilled workers - specifically chondrocytes in cartilage and tenocytes in tendons - remain fully active, supplied, and capable of completing the restoration. At the cellular level, NSAIDs exert their effects through the catalytic inhibition of cyclooxygenase enzymes, categorized as constitutive cyclooxygenase-1 (COX-1) and inducible cyclooxygenase-2 (COX-2). Membrane phospholipids damaged during injury release arachidonic acid, which COX enzymes convert into pro-inflammatory lipid mediators known as prostanoids, most notably prostaglandin E2 (PGE2). Nonselective NSAIDs block both isoforms, while selective coxibs specifically target COX-2. By shutting off PGE2 production, NSAIDs rapidly elevate pain thresholds and blunt localized swelling. However, because PGE2 also functions as a vital signaling cue for cellular recruitment, angiogenesis, and cellular proliferation, this total enzymatic shutdown strips local repair cells of the baseline signals required to orchestrate tissue regeneration. Curcumin avoids this indiscriminate pathway paralysis by acting upstream on master transcriptional control switches rather than directly neutralizing isolated enzymes. Its primary therapeutic mechanism centers on the inhibition of Nuclear Factor-kappa B (NF-kB) and Activator Protein-1 (AP-1) signaling networks. Under acute stress or chronic inflammatory loads, the NF-kB protein complex is released from its cytoplasmic inhibitor, IkBa, and translocates directly into the cell nucleus, where it drives the transcription of catabolic cytokines such as interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-a), and interleukin-6 (IL-6). Curcumin blocks the phosphorylation and degradation of IkBa, effectively keeping NF-kB trapped in the cytoplasm. By preventing this nuclear entry, curcumin attenuates the expression of pro-inflammatory cytokines and downstream matrix-degrading enzymes while preserving baseline physiological functions. Furthermore, curcumin activates the nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant response element (ARE) pathways, which upregulate endogenous cellular antioxidants to neutralize destructive reactive oxygen species (ROS) that induce cell death in injured joints.
The Mechanisms of NSAID-Induced Inhibition in Cartilage and Tendon RepairArticular cartilage and tendons are specialized, bradytrophic connective tissues characterized by relatively low basal metabolic rates and limited endogenous vascular supplies. These physical constraints make their cellular maintenance highly vulnerable to pharmaceutical disruptions. When synthetic compounds impair cell migration, survival, or extracellular matrix secretion, the intrinsic repair capacity of these structures is substantially degraded.Cartilage maintenance depends on chondrocytes, the sole cell type residing within articular joints, which are responsible for generating and maintaining the extracellular matrix of Type II collagen and water-binding proteoglycans such as aggrecan. Because adult articular cartilage lacks a direct vascular network, major defect repair relies heavily on the recruitment and chondrogenic differentiation of subchondral mesenchymal stem cells (MSCs) through endochondral ossification. Experimental evaluations demonstrate that systemic or intra-articular NSAID exposure halts this regenerative differentiation. Both nonselective NSAIDs and selective COX-2 inhibitors interfere with chondrocyte maturation and prevent successful tissue integration following cartilage transplantation or microfracture procedures. At the cellular level, common NSAIDs - including indomethacin, ketorolac, and diclofenac - induce cell cycle arrest in chondrocytes by blocking transition from the resting G0 phase to the proliferative G1. phase, substantially reducing viable cell numbers. Concurrently, NSAIDs downregulate Bone Morphogenetic Protein-2 (BMP-2), an essential anabolic signaling molecule that orchestrates matrix synthesis. Histological analyses in animal models reveal that NSAID administration causes a marked loss of extracellular proteoglycan content and widespread chondrocyte depletion, yielding elevated modified Mankin scores that signify advanced structural degeneration. In layman's terms, proteoglycans serve as water-absorbing structural sponges that grant cartilage its elastic shock absorption. When NSAIDs deplete these molecules, the joint surface dries out, becomes brittle, and rapidly wears down under routine mechanical friction. Tendon healing is similarly susceptible to disruption by NSAIDs. Tendons operate as high-tensile structural cables composed of longitudinally arranged Type I collagen fibers, maintained by specialized fibroblasts termed tenocytes and tenoblasts. Healing after acute rupture or chronic tear progresses through an initial inflammatory phase, followed by a proliferative phase of cell migration, and culminates in a lengthy remodeling phase of collagen alignment. In vitro and in vivo studies establish that NSAIDs directly suppress the migration and proliferative capacity of tenocytes during the critical early healing window. Without an adequate cellular workforce migrating into the wound bed, provisional collagen scaffolding cannot be synthesized effectively. The disruption is particularly pronounced at the enthesis, the specialized fibrocartilaginous junction where soft tendon inserts into rigid bone. Re-establishing this transition zone requires coordinated bone remodeling and chondrogenic differentiation, both of which are hindered by COX inhibition. In animal rotator cuff repair models, early administration of NSAIDs significantly delays collagen fiber organization and impairs mechanical integration at the insertion site, resulting in a measurable decline in load-to-failure strength and overall tendon toughness. Furthermore, while prolonged inflammation contributes to pathological degeneration, the transient synthesis of PGE2 during the initial hours following injury is essential for regulating localized microvascular flow and hyperemic nutrient delivery. By eliminating this early prostanoid pulse, NSAIDs starve the repair zone of oxygen and circulating factors precisely when the cellular metabolic demand is highest. Beyond direct biochemical cytotoxicity, systemic NSAIDs introduce a physical hazard known as analgesic arthropathy. In musculoskeletal biomechanics, pain functions as a protective feedback mechanism, forcing the patient to unload an injured joint or limb to prevent structural overload. By effectively blunting the pain reflex while simultaneously undermining the cellular synthesis of proteoglycans and collagen, NSAIDs create a deceptive state of perceived recovery. Patients prematurely resume unrestricted weight-bearing and strenuous activity, placing substantial, uncompensated mechanical forces onto compromised cartilage surfaces and unhealed tendon fibers. Over time, this recurring mechanical trauma accelerates joint space narrowing, promotes microfractures in the subchondral plate, and hastens functional joint breakdown. Chondroprotective and Tenogenic Mechanisms of CurcuminIn sharp contrast to the suppressive actions of synthetic COX inhibitors, curcumin exhibits a tissue-sparing, pro-regenerative biological profile. Rather than paralyzing cellular metabolism, curcumin modulates the microenvironment by suppressing destructive catabolic enzymes while supporting the baseline anabolic signals required for cartilage and tendon reconstruction.In articular cartilage, curcumin acts as a direct chondroprotective agent by dismantling the catabolic cascade induced by pro-inflammatory cytokines. When joint tissues are exposed to elevated IL-1ß and TNF-a, chondrocytes are provoked to synthesize matrix metalloproteinases - specifically collagenases such as MMP-1, MMP-3, and MMP-13 - along with aggrecanases like ADAMTS5. These enzymes function like enzymatic shears, systematically slicing through structural Type II collagen strands and degrading aggrecan cores. Curcumin suppresses the transcription and secretion of MMP-1, MMP-3, MMP-13, and ADAMTS5 by neutralizing NF-kB and AP-1 activation. Concurrently, it upregulates Cbp/p300 Interacting Transactivator with ED-rich tail 2 (CITED2), an essential transcriptional regulator that represses matrix metalloproteinases at the genomic level. In addition to halting extracellular degradation, curcumin protects chondrocytes from inflammatory apoptosis. Exposure to oxidative stress and inflammatory cytokines typically triggers programmed cell death by activating the intrinsic caspase cascade. Curcumin suppresses this apoptotic pathway by reducing the cleavage of executioner caspase-3, downregulating the pro-apoptotic factor Bax, and elevating anti-apoptotic Bcl-2 expression. Microscopic and histological analyses of osteoarthritic cartilage treated with curcumin consistently show robust Safranin O staining, intact surface regularity, preserved chondrocyte density, and significantly reduced Osteoarthritis Research Society International (OARSI) degradation scores. Within tendon biology, curcumin promotes active tissue regeneration (tenogenesis) rather than inert scar formation. In animal models of tendon rupture and surgical repair, curcumin guides tendon-derived stem and progenitor cells (TSPCs) toward mature tenocyte differentiation. This lineage-specific differentiation is orchestrated primarily through activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and Wnt/ß-catenin signaling cascades. As stem cells commit to the tenogenic pathway, they significantly upregulate crucial structural and phenotypic markers, including epithelial cell adhesion molecule (EpCAM), tenomodulin, and the master tendon transcription factor Scleraxis. Through this guided differentiation, curcumin supports the preferential synthesis and organized deposition of high-tensile Type I collagen fibers, the primary architectural building blocks of healthy tendons. Injured tendons typically fill with disorganized, loose Type III collagen, which forms a structurally inferior, compliant scar. Curcumin supplementation promotes the progressive maturation from primitive Type III collagen to densely packed, parallel Type I collagen fibrils, restoring native tensile strength and mechanical breaking force. A major clinical challenge following tendon surgery is the development of peritendinous adhesions, in which excessive fibrotic scar tissue binds the healing tendon to its synovial sheath, restricting range of motion and joint gliding. Postoperative tendon repair involves a balance between extrinsic healing (in which exterior fibroblasts infiltrate the defect and deposit messy scar tissue) and intrinsic healing (in which tenocytes within the tendon substance reconstruct the matrix). Curcumin suppresses excessive peritendinous inflammation and extrinsic fibrosis while accelerating intrinsic tenocyte repair. Biomechanical testing confirms that local or systemic curcumin administration yields lower adhesion scores, increased gliding distances, and superior functional mobility without sacrificing structural load-bearing capacity. Comparative Clinical Efficacy and Systemic Safety ProfilesTranslating cellular findings into clinical practice requires weighing therapeutic outcomes against systemic safety profiles. While synthetic NSAIDs deliver potent, rapid analgesia during acute musculoskeletal pain events, their chronic administration is constrained by systemic toxicities across multiple organ systems.In randomized, active-controlled clinical trials of knee osteoarthritis, optimized curcumin preparations have demonstrated clinical pain reduction and functional recovery comparable to standard therapeutic doses of NSAIDs. In a randomized, open-label parallel-arm study evaluating 139 patients with symptomatic knee osteoarthritis, subjects received either 500 mg of a bio-enhanced curcumin extract three times daily or 50 mg of diclofenac sodium twice daily for 28 consecutive days. Patients treated with curcumin demonstrated comparable improvements in pain intensity on the Visual Analogue Scale (VAS) and functional scores on the Knee Injury and Osteoarthritis Outcome Score (KOOS) at days 14 and 28, showing no statistically significant difference in therapeutic efficacy compared to diclofenac. However, the systemic tolerability profiles between the treatments diverged markedly. Overall adverse events occurred in only 13% of the curcumin group compared to 38% of the diclofenac cohort. In the diclofenac arm, 28% of patients developed dyspeptic symptoms severe enough to require concurrent treatment with H2-receptor antagonists or proton pump inhibitors to prevent mucosal ulceration, whereas no patients in the curcumin cohort required gastroprotective intervention. Furthermore, the curcumin cohort experienced a significant reduction in flatulence and digestive discomfort, demonstrating beneficial gastric and intestinal cytoprotective effects. These safety observations are consistent across broader systematic reviews and meta-analyses. Nonsteroidal anti-inflammatory agents inherently compromise gastrointestinal integrity by systematically depleting cytoprotective prostaglandins, leaving the gastric epithelium vulnerable to acid erosion and hemorrhage. In addition, systemic inhibition of renal and vascular COX enzymes by NSAIDs reduces renal perfusion and disrupts the balance between prostacyclin and thromboxane, elevating the risk of fluid retention, hypertension, and adverse cardiovascular thrombotic events. Curcumin does not suppress these physiological prostanoid pathways, making it free from ulcerogenic, nephrotoxic, and cardiotoxic properties at therapeutic dosages.
A longstanding limitation of standard curcumin supplementation in clinical settings has been its low oral bioavailability. Native curcuminoids are highly lipophilic, poorly soluble in aqueous gastric fluids, and subject to rapid hepatic and intestinal phase II metabolism into inactive glucuronides and sulfates, leading to swift biliary and fecal excretion. Consequently, raw culinary turmeric powders struggle to achieve the therapeutic systemic circulating concentrations required to reach poorly vascularized joint and tendon compartments. Modern pharmacognosy has addressed this pharmacodynamic hurdle through advanced delivery formulations. Modern strategies - such as co-administration with the natural alkaloid piperine (which inhibits hepatic glucuronidation), micellar dispersions, phytosomal phospholipid complexes, and bio-enhanced submicron dispersions - elevate systemic blood bioavailability by ten- to thirty-fold compared to unformulated extracts. These modern delivery platforms ensure that therapeutic concentrations reach synovial fluid, subchondral bone, and fibrous tendon sheaths without requiring excessive oral dosing. Conclusions and Translational Clinical ImplicationsThe biological and clinical evidence reveals distinct physiological paths for NSAIDs and curcumin in orthopedic recovery. While NSAIDs remain powerful tools for the brief alleviation of acute, unmanageable pain, their ongoing administration during active tissue healing presents substantial biological compromises. Tendons and cartilage require a controlled, transient inflammatory cascade to signal cell recruitment, stimulate stem cell differentiation, and direct extracellular matrix synthesis. By completely shutting down cyclooxygenase enzymes and depleting local prostaglandins, NSAIDs disrupt this regenerative cascade. The resulting cellular consequences - including chondrocyte cell cycle arrest, proteoglycan loss, suppression of tenocyte migration, and weakened collagen tensile strength at the tendon-to-bone interface - demonstrate that pain relief from NSAIDs frequently comes at the cost of the structural integrity of healing connective tissues.In contrast, curcumin provides a tissue-preserving alternative that decouples pain and inflammation control from cellular suppression. Operating upstream at the level of NF-kB and AP-1 transcriptional activation, curcumin attenuates the expression of pro-inflammatory cytokines while leaving the physiological baseline of cellular metabolism intact. In cartilage, it actively represses the matrix-degrading enzymes MMP-1, MMP-3, MMP-13, and ADAMTS5, maintains water-binding proteoglycan content, and protects chondrocytes from inflammatory apoptosis. In damaged tendons, curcumin stimulates tenogenic differentiation of local stem cells via PI3K/Akt signaling, supports the proper maturation of dense Type I collagen fibers, and prevents restrictive peritendinous scar adhesions, preserving both joint mobility and mechanical breaking strength. From a translational perspective, these findings indicate that clinical protocols should reconsider relying on continuous NSAIDs as the default intervention for connective tissue injuries, post-surgical recovery, and chronic degenerative conditions. Where synthetic NSAIDs are deemed necessary, their use should be confined to short-term acute flare-ups to avoid interrupting early tissue remodeling. For long-term joint preservation, ongoing tendinopathy rehabilitation, and chronic osteoarthritis management, optimized bio-enhanced curcumin formulations deliver pain relief and functional restoration comparable to conventional pharmaceuticals, all while preserving the biological processes required for lasting musculoskeletal repair. References: NSAID therapy effects on healing of bone, tendon, and the enthesis The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Conservative management of symptomatic knee osteoarthritis - PMC Positives and negatives of nonsteroidal anti-inflammatory drugs in (PDF) Conservative management of symptomatic knee osteoarthritis Non-steroidal anti-inflammatory drugs influence cartilage healing Is Curcumine Useful in the Treatment and Prevention of ... - PMC - NIH Efficacy and mechanisms of curcumin in the treatment of osteoarthritis Biological actions of curcumin on articular chondrocytes - PubMed Curcumin slows osteoarthritis progression and relieves ... - PMC - NIH Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Anti-inflammatory management for tendon injuries - friends or foes? The mechanistic role of curcumin on matrix metalloproteinases in Therapeutic effects of turmeric or curcumin extract on pain and Curcumin inhibits chondrocyte apoptosis and inflammation in ... - PMC Analysis of the mechanism of curcumin against osteoarthritis using Synergistic enhancement of tendon-to-bone healing via anti ... - PMC A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis A randomized, pilot study to assess the efficacy and safety ... - PubMed Effectiveness of curcuminoids in the treatment of knee osteoarthritis THE EFFECTS OF TRADITIONAL STRENGTHENING EXERCISES Putting Some Muscle into Osteoarthritis | Annals of Internal Medicine Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect Calebin A, a Compound of Turmeric, Down-Regulates Inflammation The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to Chiropractor in Toronto, ON, Canada :: Head and Neck Pain Investigation of the association of long-term NSAID use with ... - PMC Curcumin Improves Functional Recovery of Ruptured Tendon by Chemically modified curcumin (CMC2.24) alleviates osteoarthritis Curcumin improves age-related and surgically induced osteoarthritis (PDF) Curcumin Improves Functional Recovery of Ruptured Tendon Investigation of the effects of umbilical cord-derived mesenchymal Effect of curcumin-loaded polycaprolactone scaffold on Achilles Controlled release of curcumin from curcumin-loaded nanomicelles Efficacy and safety of combination of curcuminoid complex ... - PMC The efficacy of Curcuma Longa L. extract as an adjuvant therapy in
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6653) The Ultimate Guide to Cellular Longevity: NAD+, Methylation, and Senolytics 
Date:
September 10, 2026 10:57 AM
Introduction: Understanding Cellular Aging and Energy DeclineBiological aging represents a progressive decline in cellular maintenance, structural repair, and energy generation. Over decades, tissues experience an attrition of functional reserves, compromised stress resilience, and persistent low-grade systemic inflammation. At the cellular scale, biological degeneration is driven by a failure to generate bioenergetic fuel, repair genetic code, and clear metabolic waste.Cellular aging is characterized by interconnected biological disruptions known as the hallmarks of aging. These encompass genomic instability, epigenetic alterations, mitochondrial decay, loss of proteostasis, and cellular senescence. Rather than operating as isolated occurrences, these phenomena establish a self-reinforcing degenerative cycle: declining cellular power generation impairs enzymatic genetic repair, promoting the accumulation of damaged cells that enter irreversible growth arrest and poison surrounding healthy tissues. Mitigating cellular aging requires examining how microscopic bioenergetic pathways deteriorate and evaluating how targeted nutritional and biochemical interventions can restore cellular homeostasis. The Role of Mitochondria and ATP ProductionEvery biological function - from muscular contraction to continuous DNA replication - depends on adenosine triphosphate (ATP), the primary biochemical energy currency of living systems. Cells produce the vast majority of this energy within mitochondria through oxidative phosphorylation. Within these specialized organelles, metabolic intermediates derived from dietary carbohydrates and lipids donate high-energy electrons to the electron transport chain. The flow of these electrons across protein complexes establishes an electrochemical proton gradient across the inner mitochondrial membrane, driving ATP synthase to manufacture ATP.A youthful cell functions like an efficient municipal power grid, dynamically matching energetic demands with immediate ATP output. However, as biological aging progresses, mitochondrial efficiency declines. The electron transport chain becomes structurally leaky, inadvertently shedding electrons that react with ambient molecular oxygen to produce reactive oxygen species (ROS). While regulated levels of ROS participate in vital intracellular signaling, chronic excess induces widespread oxidative stress. Mitochondria are exceptionally vulnerable to this oxidative burden because they carry their own circular genetic material, known as mitochondrial DNA (mtDNA). Unlike nuclear DNA, mtDNA lacks the protective shielding of histone proteins and possesses rudimentary repair systems. As a result, mtDNA sustains cumulative oxidative damage, encoding increasingly defective electron transport chain proteins. This dynamic generates a bioenergetic deficit: degraded mitochondria synthesize progressively less ATP while emitting greater volumes of damaging free radicals. Deprived of optimal ATP reserves, cells lack the energy necessary to drive vital enzymatic repair cascades, accelerating structural degeneration and functional exhaustion. How Cellular Senescence Accelerates the Aging ProcessWhen healthy cells confront critical physiological damage - such as severe telomere attrition, persistent DNA double-strand breaks, or oxidative stress - they activate protective cell cycle arrest pathways governed primarily by the p53/p21^CIP1 and p16^INK4a/Rb molecular checkpoints. This defensive shutdown, termed cellular senescence, permanently prevents the replication of potentially premalignant or mutated cells.Senescent cells, colloquially known as "zombie cells," enter a state of permanent growth arrest while actively resisting programmed cell death (apoptosis). Over time, these cells accumulate within adipose depots, skeletal muscle, the vascular endothelium, and major organs, largely because immune surveillance and clearance pathways simultaneously lose functional efficiency. The systemic danger of senescent cells stems from their secretome. Rather than remaining biologically inert, senescent cells develop a hyperactive secretory state termed the Senescence-Associated Secretory Phenotype (SASP). The SASP is a destructive mixture of pro-inflammatory cytokines, chemokines, extracellular matrix-degrading matrix metalloproteinases (MMPs), and reactive oxygen species. Through this toxic secretome, even a small burden of senescent cells can impair whole-tissue architecture. SASP factors degrade surrounding structural proteins, induce insulin resistance in neighboring metabolic cells, and biochemically force adjacent healthy cells into secondary senescence. This persistent paracrine signaling fuels chronic, sterile, low-grade systemic inflammation, termed "inflammaging," which accelerates systemic tissue degeneration and elevates susceptibility to degenerative age-related pathologies. Nicotinamide Riboside (NR) and the NAD+ Salvage PathwayThe Biochemistry of NAD+ Depletion Over TimeNicotinamide adenine dinucleotide (NAD+) is an indispensable coenzyme present in every living cell. NAD+ fulfills a dual biological mandate: it serves as a central redox cofactor that shuttles electrons between cellular metabolic reactions, and it functions as an obligatory consumable substrate for regulatory enzymes that preserve cellular viability. In its redox capacity, NAD+ accepts electrons to form NADH during glycolysis, the tricarboxylic acid (TCA) cycle, and fatty acid beta-oxidation, subsequently donating those electrons to Complex I of the respiratory chain to power ATP synthesis.
The primary enzymatic driver of age-related NAD+ destruction is CD38, a membrane-bound glycohydrolase expressed on immune cells that is upregulated in response to chronic SASP exposure. Concurrently, lifelong genotoxic damage causes persistent activation of Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that cleaves the glycosidic bonds of NAD+ to assemble branched poly(ADP-ribose) chains at DNA lesion sites. Because PARP-1 consumes NAD+ without directly recycling the molecule, chronic DNA damage depletes intracellular NAD+ pools, impairing bioenergetics and limiting sirtuin activity. How NR Efficiently Boosts Cellular NAD+ LevelsThe mammalian body maintains its NAD+ supply through three distinct biosynthetic routes: the de novo pathway from dietary L-tryptophan, the Preiss-Handler pathway from nicotinic acid (niacin), and the NAD+ Salvage Pathway. The de novo pathway requires substantial energy expenditure, consuming roughly sixty milligrams of dietary tryptophan to yield a single milligram of NAD+. The Preiss-Handler pathway, while effective, can induce cutaneous prostaglandin-mediated flushing at therapeutic intakes. Consequently, the salvage pathway serves as the primary mechanism for maintaining intracellular NAD+ pools.The salvage pathway recycles the breakdown product nicotinamide (NAM), which is released whenever NAD+-consuming enzymes execute their functions. Under normal conditions, cells convert free nicotinamide into nicotinamide mononucleotide (NMN) via the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT), after which NMN adenylyltransferases (NMNAT1–3) complete the conversion into NAD+. However, NAMPT expression declines with advancing age, chronic inflammation, and metabolic stress, limiting the recycling capacity of the cell. Nicotinamide Riboside (NR) is a naturally occurring pyridine nucleoside that bypasses this enzymatic bottleneck. Upon cellular entry via equilibrative nucleoside transporters, NR is directly phosphorylated into NMN by nicotinamide riboside kinases (NRK1 and NRK2) using a single molecule of ATP. Because the NRK pathway remains intact and robust across the lifespan, NR provides an efficient alternative entry point into the NAD+ salvage cascade. Clinical evaluations in humans confirm the safety, bioavailability, and pharmacokinetics of oral NR supplementation. Randomized, double-blind, placebo-controlled trials reveal that oral NR chloride produces dose-dependent increases in steady-state whole blood NAD+ concentrations. Dosing regimens of 100 mg, 300 mg, and 1,000 mg daily elevate blood NAD+ levels by approximately 22%, 51%, and up to 142%, respectively, within two weeks of administration, maintaining these elevations throughout continuous use. High-resolution metabolomic analyses also demonstrate parallel elevations in nicotinic acid adenine dinucleotide (NAAD), establishing it as a reliable biomarker of active intracellular NAD+ synthesis without hepatic or systemic toxicity. Sirtuin Activation and DNA Repair MechanismsReplenishing intracellular NAD+ supports functions beyond mitochondrial ATP generation. NAD+ functions as an obligatory cofactor for sirtuins (SIRT1 through SIRT7), a family of class III histone and non-histone protein deacetylases that regulate stress resilience, metabolic homeostasis, and cell survival. Sirtuins couple the removal of acetyl groups from target lysine residues to the stoichiometric cleavage of NAD+, producing nicotinamide and O-acetyl-ADP-ribose. In states of NAD+ deficiency, sirtuin enzymes remain inactive regardless of cellular demand.In the nucleus, SIRT1 coordinates defense against cellular decline. When activated by restored NAD+ levels, SIRT1 deacetylates peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a), the master transcriptional coactivator of mitochondrial biogenesis. This deacetylation stimulates mitochondrial replication and assembly, Expanding functional respiratory capacity. Concurrently, SIRT1 deacetylates the p65 subunit of nuclear factor-kappa B (NF-kB), suppressing the transcription of pro-inflammatory cytokines. In the mitochondria, SIRT3 utilizes NAD+ to deacetylate metabolic enzymes and superoxide dismutase 2 (SOD2), enhancing the organelle's capacity to neutralize reactive oxygen species. At the same time, cellular NAD+ levels directly regulate genomic integrity through PARP-1. When genotoxic stress or oxidative damage induces single- or double-strand DNA breaks, PARP-1 binds to the damaged termini using its zinc-finger domains. Bound PARP-1 hydrolyzes NAD+ to synthesize extensive, negatively charged poly(ADP-ribose) polymers on itself and adjacent histones. This modification relaxes chromatin architecture and establishes an electrostatic scaffold that recruits base excision repair and homologous recombination complexes. Recent discoveries demonstrate close crosstalk between sirtuins and PARP-1 during DNA repair. PARP-1 recruits SIRT1 to double-strand breaks, where SIRT1 deacetylates the chromatin-remodeling ATPase BRG1 to displace nucleosomes and facilitate homologous recombination. However, because PARP-1 and SIRT1 draw from the same intracellular NAD+ pool, severe NAD+ depletion forces a biological compromise: PARP-1 consumes the scarce remaining cofactor to address DNA damage, leaving sirtuins deactivated. Restoring NAD+ via NR prevents this deficit, enabling concurrent genomic repair and sirtuin-mediated metabolic defense. Quercetin: A Powerful Senolytic and mTOR RegulatorClearing Senescent "Zombie" Cells from TissuesThe accumulation of senescent cells has driven interest in senolytics: molecules that selectively eliminate senescent cells while sparing healthy, non-senescent populations. Senolytic agents exploit a specific vulnerability in senescent cells. Because senescent cells produce cytotoxic, pro-inflammatory SASP factors that would normally induce their own death, they become dependent on upregulated Senescent Cell Anti-Apoptotic Pathways (SCAPs) to survive. The SCAP network involves anti-apoptotic proteins (such as BCL-2 and BCL-xL), the PI3K/Akt kinase cascade, and cyclin-dependent kinase inhibitors.Quercetin is a polyphenolic flavonoid found in capers, red onions, apples, and the flower buds of Sophora japonica. Beyond its classical antioxidant properties, quercetin functions as a senolytic compound that exerts multi-target inhibitory effects across the SCAP network. By inhibiting the upstream PI3K/Akt survival axis and downregulating anti-apoptotic defenses, quercetin disrupts the signaling that protects senescent cells from intrinsic apoptosis. Deprived of these survival signals, senescent cells undergo programmed cell death. Preclinical studies demonstrate that senolytic protocols utilizing quercetin - often combined with the tyrosine kinase inhibitor dasatinib - reduce senescent cell burden across multiple tissues. This targeted clearance lowers circulating SASP factors, attenuates tissue fibrosis, restores endothelial reactivity, and improves functional health span. By removing senescent cells, quercetin mitigates the primary driver of chronic, low-grade inflammaging. Modulating the mTOR Pathway for Optimal AutophagyThe mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine protein kinase that coordinates cellular metabolism by balancing anabolic growth with catabolic recycling. Operating within two multiprotein complexes - mTORC1 and mTORC2 - the mTOR pathway integrates signals from amino acids, growth factors, and intracellular energy levels. In nutrient-rich environments, mTORC1 promotes protein synthesis, lipogenesis, and cellular growth, while suppressing catabolic breakdown. Conversely, nutrient scarcity downregulates mTORC1, activating autophagy.Autophagy is an intracellular degradation system that packages damaged organelles, misfolded protein aggregates, and biological debris into double-membraned autophagosomes for lysosomal degradation and recycling. A specialized branch of this pathway, mitophagy, selectively targets and clears damaged mitochondria. In modern metabolic conditions characterized by continuous caloric intake, mTORC1 can remain persistently active. This persistent signaling suppresses autophagy, causing damaged organelles and toxic aggregates to accumulate within tissues. Quercetin functions as a natural modulator of mTOR signaling. By inhibiting upstream PI3K/Akt signaling and activating intracellular energy sensors, quercetin attenuates overactive mTORC1, mimicking the metabolic effects of caloric restriction. This down-regulation relieves inhibition on the ULK1 autophagy initiation complex, stimulating both general autophagy and mitophagy. As autophagy proceeds, cells clear protein aggregates and eliminate damaged mitochondria, supporting cellular longevity and proteostasis. Enhancing Absorption: Phytosomes and Dietary FatsDespite the biological activities of quercetin identified in experimental models, its clinical translation has historically been limited by poor oral bioavailability. Raw quercetin aglycone is a crystalline, hydrophobic polyphenol with poor solubility in water and gastrointestinal fluids. When ingested in unformulated powder forms, quercetin molecules aggregate in the gut lumen, resisting dissolution and passive absorption. Consequently, the vast majority of an unformulated dose passes into the colon unabsorbed, where it undergoes microbial degradation without reaching meaningful systemic concentrations.To address these pharmacokinetic limitations, advanced delivery systems such as phytosomes were engineered. A phytosome is a 100% food-grade molecular complex where individual polyphenolic molecules are bound to dietary phospholipids, typically sunflower-derived phosphatidylcholine. Unlike a classical liposome - which encapsulates water-soluble compounds inside an aqueous core enclosed by a lipid bilayer - a phytosome forms an amphiphilic complex at the molecular level. The polar head of the phosphatidylcholine molecule forms hydrogen bonds with the hydroxyl groups of the quercetin molecule, while its lipophilic fatty acid tails extend outward. This structural arrangement shields the polar regions of the flavonoid, creating a lipid-compatible complex that integrates smoothly into the intestinal mucosa.
The Importance of Methylation in Healthy AgingVitamin B-Complex and Choline as Essential Methyl DonorsMethylation is an essential biochemical process occurring billions of times each second across all human tissues. It involves the transfer of a single-carbon unit - a methyl group consisting of one carbon atom bound to three hydrogen atoms - (CH3) - from a donor molecule to diverse recipients, including DNA, RNA, structural proteins, neurotransmitters, and membrane phospholipids. This transfer of one-carbon units is coordinated by the methionine-homocysteine cycle, which sustains genetic stability, detoxification pathways, and cellular repair.At the center of this pathway sits S-adenosylmethionine (SAM), the universal methyl donor in human biology. When a methyltransferase enzyme transfers a methyl group from SAM to an acceptor molecule, SAM is converted into S-adenosylhomocysteine (SAH). SAH functions as a potent competitive inhibitor of intracellular methyltransferases. To maintain functional methylation, SAH is rapidly hydrolyzed into homocysteine, a sulfur-containing amino acid that must be remethylated or cleared through transsulfuration. Homocysteine clearance proceeds through two distinct remethylation pathways. The primary route operates across most tissues via the enzyme methionine synthase, which requires vitamin B12 in its active methylcobalamin form. Methionine synthase transfers a methyl group from 5-methyltetrahydrofolate (5-MTHF, the active form of folate) to homocysteine, regenerating methionine. The ongoing production of 5-MTHF depends on the enzyme methylenetetrahydrofolate reductase (MTHFR), which utilizes riboflavin (vitamin B2) as a cofactor. Alternatively, excess homocysteine can be routed into the transsulfuration pathway by vitamin B6 (as pyridoxal-5'-phosphate) to synthesize cystathionine, cysteine, and ultimately the antioxidant glutathione. A secondary remethylation pathway, active predominantly in hepatic and renal tissues, bypasses folate entirely. In this route, dietary choline is oxidized to betaine (trimethylglycine or TMG). The enzyme betaine-homocysteine S-methyltransferase (BHMT) then transfers a methyl group from betaine directly to homocysteine, yielding methionine and dimethylglycine. When dietary intake of active B-vitamins or choline is insufficient, or when genetic variations like MTHFR polymorphisms reduce pathway flux, the methylation cycle slows. Homocysteine accumulates in circulation, promoting vascular and neurological inflammation, while SAM reserves decline, restricting cellular methylation capacity. Understanding DNA Methylation and Epigenetic HealthEvery somatic cell in an organism carries an identical genetic code. Cellular differentiation and tissue-specific functions are governed by the epigenome: a regulatory layer of chemical modifications that dictates gene expression without altering underlying DNA sequences. DNA methylation represents the primary and most stable epigenetic modification. In this process, DNA methyltransferase (DNMT) enzymes utilize methyl groups donated by SAM to add a methyl tag to cytosine bases adjacent to guanine residues, forming 5-methylcytosine within CpG dinucleotide sites.Under physiological conditions, DNA methylation maintains genomic stability and coordinates transcription. Methylation of promoter regions condenses chromatin, repressing transposable elements and silencing genes inappropriate for a given cell type. Conversely, hypomethylated promoters maintain an open chromatin state, allowing transcription factors to bind and initiate gene expression. During biological aging, this epigenetic landscape undergoes progressive dysregulation, a phenomenon termed "epigenetic drift". Aging cells experience global hypomethylation alongside focal hypermethylation of specific gene promoters. Global loss of methyl tags destabilizes the genome, activating retrotransposons and pro-inflammatory pathways. Simultaneously, hypermethylation at targeted promoter sites silences critical tumor suppressor genes and DNA repair complexes. This systematic change in DNA methylation patterns is consistent across populations, allowing researchers to develop molecular "epigenetic clocks". Algorithms such as the Horvath clock, PhenoAge, and GrimAge quantify biological age by profiling the methylation status of specific CpG sites across the genome. These clocks assess whether individuals are aging faster or slower than their chronological years. Ensuring a steady supply of methyl donors and preventing unnecessary SAM depletion supports DNMT activity, maintaining epigenetic patterns and genomic stability. How the Methylation Cycle Impacts Energy and Cognitive FocusBeyond long-term epigenetic regulation, the methylation cycle directly modulates immediate biochemical processes that govern daily energy, neurotransmission, and cognitive focus. Compromised methylation capacity frequently manifests as cognitive slowing, executive fatigue, and reduced physical stamina.A major consumer of methyl reserves is the endogenous synthesis of creatine. Approximately 40% of all SAM-derived methyl groups in the human body are utilized by guanidinoacetate N-methyltransferase (GAMT) in the liver to synthesize creatine. Creatine then translocates to the brain and skeletal muscle, where it is phosphorylated into phosphocreatine. Phosphocreatine functions as a rapid energy buffer, donating a high-energy phosphate group to regenerate ADP into ATP in milliseconds during demanding physical or cognitive tasks. When methyl donor availability falls, endogenous creatine synthesis drops, depleting phosphocreatine reserves and increasing susceptibility to neuromuscular and cognitive fatigue. Methylation is equally central to central nervous system architecture. SAM provides methyl groups to convert phosphatidylethanolamine into phosphatidylcholine, the predominant phospholipid comprising neuronal cell membranes and the myelin sheaths that insulate axons. Intact myelin preserves rapid action potential conduction throughout the nervous system. Furthermore, free choline derived from this pathway is the direct precursor to acetylcholine, the neurotransmitter required for attention, working memory, and learning. The methylation cycle also governs monoamine neurotransmitter metabolism. SAM is required for the synthesis of adrenaline (epinephrine) from noradrenaline, while catechol-O-methyltransferase (COMT) relies on SAM to degrade dopamine and norepinephrine within the prefrontal cortex. Sluggish methylation disrupts this balance, contributing to cognitive fatigue, mood variability, and impaired mental performance. Building a Comprehensive Longevity ProtocolSynergizing NR, Quercetin, and Methylated B-VitaminsLongevity supplementation often falters when single molecules are administered in isolation, ignoring interconnected metabolic pathways. Designing an effective cellular longevity protocol requires combining complementary mechanisms that reinforce one another while preventing secondary metabolic deficits. The combination of Nicotinamide Riboside, Quercetin Phytosome, and Methylated B-Vitamins illustrates this multi-target synergy.This synergy is grounded in the direct biochemical intersection between the NAD+ salvage pathway and the methylation cycle. When high-dose NR is supplemented to boost systemic NAD+, sirtuins and PARP enzymes consume the newly synthesized cofactor, generating substantial quantities of free nicotinamide (NAM). This intracellular nicotinamide faces two primary metabolic fates: it can be recycled back into NAD+ through the NAMPT-dependent salvage loop, or it can be cleared via methylation. When the influx of nicotinamide exceeds salvage recycling capacity, the excess is cleared to avoid feedback inhibition of sirtuin enzymes. To accomplish this, the enzyme nicotinamide N-methyltransferase (NNMT) transfers a methyl group from SAM directly onto nicotinamide, forming 1-methylnicotinamide (1-MNA/MNAM), which is subsequently excreted in urine. Prolonged, high-dose precursor administration without nutritional methyl support can elevate NNMT flux, depleting intracellular SAM reserves. As methyl groups are consumed clearing nicotinamide, the cellular SAM-to-SAH ratio falls, which can elevate circulating homocysteine and reduce methyl availability for DNA methylation and neurotransmitter synthesis. Co-administering a fully methylated B-complex alongside choline or betaine addresses this potential bottleneck. Providing active methyl donors (such as 5-MTHF, methylcobalamin, and betaine) maintains the one-carbon donor pool. Even during increased NNMT activity, SAM pools remain stable, protecting DNA methylation fidelity and maintaining homocysteine within safe parameters. Quercetin reinforces this protocol through complementary mechanisms. By clearing senescent cells and reducing SASP-mediated inflammation, quercetin downregulates CD38, the primary enzyme responsible for age-related NAD+ degradation. Suppressing CD38 prevents unnecessary breakdown of newly synthesized NAD+, enhancing the efficiency of NR supplementation. Furthermore, while NR provides the NAD+ necessary to activate SIRT1-driven mitochondrial biogenesis, quercetin concurrently modulates mTORC1 to stimulate autophagy. This coordinated action ensures that newly generated mitochondria operate in an environment cleared of proteotoxic cellular debris. The Crucial Role of Magnesium Glycinate and Zinc in Cellular FunctionLongevity protocols require essential mineral cofactors to function efficiently. Without adequate divalent minerals acting as enzymatic cofactors and structural stabilizers, metabolic longevity pathways cannot operate at full capacity. Among these, magnesium and zinc are required for cellular repair, genomic stability, and energy production.Magnesium serves as an obligatory cofactor in over 300 enzymatic reactions, primarily through its interaction with ATP. In biological systems, ATP exists predominantly as a chelate with a divalent magnesium ion, forming biologically active Mg2+ -ATP. Every enzymatic reaction that synthesizes, transfers, or consumes cellular energy - including the enzymes of the NAD+ salvage pathway (NRK and NMNAT) and DNA polymerases - strictly requires Mg2+ -ATP as its substrate. Magnesium deficiency impairs these phosphorylation reactions, reducing the cellular utilization of NAD+ precursors. Additionally, magnesium is an essential cofactor for the enzymes that activate dietary B-vitamins into their active forms. Supplying magnesium as magnesium glycinate provides high gastrointestinal bioavailability, minimal laxative effect, and yields glycine to support inhibitory neurotransmission and restful sleep. Zinc serves as a vital structural component for more than 3,000 human transcription factors and enzymatic proteins. Its most prominent structural role in longevity occurs within zinc-finger motifs. These are specialized protein conformations stabilized by a zinc ion coordinated to cysteine and histidine residues. The DNA damage sensor PARP-1 utilizes three zinc-finger domains to identify, track, and physically bind to single- and double-strand DNA breaks. Without adequate intracellular zinc, PARP-1 cannot properly assemble or dock onto damaged chromosomes, impairing DNA repair and increasing genomic instability. Zinc is also an obligatory structural component of copper/zinc superoxide dismutase (Cu/Zn-SOD or SOD1), the primary cytosolic antioxidant enzyme that dismutates superoxide radicals into hydrogen peroxide, protecting mitochondrial membranes and nuclear DNA from premature senescence. Integrating Prebiotics (like Acacia and Inulin) for Gut-Derived Longevity MarkersA comprehensive cellular longevity framework must extend beyond somatic tissues to encompass the gut microbiome. The intestinal microbiome functions as a central regulator of systemic inflammatory tone, immune development, and metabolic signaling. Age-associated dysbiosis - characterized by the loss of beneficial commensals and an overgrowth of pathobionts - frequently leads to breakdown of the intestinal barrier.The gut epithelium consists of a single-cell monolayer sealed by tight junction proteins, including zonula occludens-1 (ZO-1), occludin, and claudins. When this physical barrier is disrupted by poor dietary fiber intake or dysbiosis, gut permeability increases. This allows lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, to enter the portal and systemic circulation. The resulting "metabolic endotoxemia" activates Toll-like receptor 4 (TLR4) on immune cells, inducing NF-kB and systemic pro-inflammatory cytokine production. This persistent gut-derived inflammation exacerbates the SASP, accelerates tissue senescence, upregulates CD38, and drains systemic NAD+ reserves.
These short-chain fatty acids, particularly butyrate, exert direct protective effects on systemic longevity. Butyrate provides the primary metabolic fuel for colonic epithelial cells, supplying more than 70% of their baseline energy needs and supporting mitochondrial function within colonocytes. Furthermore, SCFAs upregulate the expression of epithelial tight junction proteins (ZO-1, occludin, and claudin-1), restoring intestinal barrier integrity and preventing the translocation of inflammatory LPS into systemic circulation. Systemically absorbed butyrate also functions as an endogenous histone deacetylase (HDAC) inhibitor, suppressing pro-inflammatory gene expression and supporting regulatory T cell (T_reg) development. Reducing metabolic endotoxemia dampens systemic inflammation, protecting vascular function and preventing premature NAD+ depletion. Conclusion: The Integrated Cellular Longevity MatrixCellular longevity is achieved not by addressing isolated biomarkers in isolation, but by systematically supporting interconnected biological pathways. As bioenergetic capacity declines, cellular senescence accelerates, epigenetic patterns degrade, and gut barrier integrity weakens. A comprehensive approach addresses these biological vulnerabilities simultaneously.
Quercetin Phytosome clears senescent cells and modulates mTORC1, stimulating autophagy while dampening the inflammatory SASP cascade that accelerates CD38-mediated NAD+ destruction. Methylated B-vitamins, active folate, and choline replenish SAM reserves, balancing the methyl requirements of NNMT-mediated nicotinamide clearance, preserving epigenetic DNA methylation, and maintaining neurotransmitter production. Magnesium glycinate and zinc provide the structural and catalytic foundation required for ATP utilization, B-vitamin activation, and PARP-1 zinc-finger DNA repair docking. Finally, prebiotic fibers generate short-chain fatty acids like butyrate, reinforcing the intestinal barrier and preventing metabolic endotoxemia from fueling systemic inflammation. By coordinating energy replenishment, cellular waste clearance, epigenetic maintenance, and the suppression of systemic inflammation, this unified approach directly addresses the underlying drivers of cellular aging to support long-term physiological vitality.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6650) Marijuana found to lower blood flow to the brain: Study authorssuggest this may increase risk of dementia, but this effect also makes itmedicinally useful for epileptics
Date:
May 10, 2019 02:17 PM
Scientific literature on how marijuana works on the body is rapidly expanding. Right now, there are a plethora of studies on how marijuana works on the human brain. Some studies have shown that it can be effective in treating disorders of the brain like epilepsy. Recent tests show that marijuana can increase the risk of dementia because it restricts the flow of blood to the brain. These brain areas are essential for memory development. The area most affected is the hippocampus which can result in Alzheimer’s if prolonged. The researchers for the study used single photo emission computed tomography (SPECT) to measure blood flow to the brain after taking marijuana and they reported that there were very low and abnormal blood flow levels observed. This is when compared with persons who did not take marijuana. 982 patients were selected from a wide variety of data sources that was available to the researchers concerning persons who previously used or were still using marijuana. The results of the study showed that persons taking marijuana were at a risk of dementia due to the low blood flow to their hippocampus. Key Takeaways:
"Users were analyzed using a brain SPECT and by conducting mental concentration tests against a sample of 100 people who had not used marijuana to determine whether there were significant differences that arose between users and non-users of cannabis." Read more: https://www.naturalnews.com/2019-04-19-marijuana-lowers-blood-flow-to-the-brain-may-be-useful-for-epileptics.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6304) Maitake Mushroom Benefits Blood Sugar, Cholesterol, Immunity & More
Date:
August 07, 2018 09:53 AM
The Maitake Mushroom (Grifola Frondosa) are an edible fungi that grows in East Asia and the US, usually clustered around the base of deciduous trees like oak and maple. Their rich taste and texture can be used in many different dishes, and the Maitake’s popularity is rapidly expanding outside of Japanese cuisine. Maitakes are adaptogenic, meaning they can help the body maintain its balance and recover from harm. This includes helping to balance blood sugar, cholesterol and blood pressure and inhibit the growth of cancer cells. Maitakes make a great addition to stir fry, pasta and other dishes. Key Takeaways:
"The maitake mushroom is no exception; not only is it delicious and full of nutrients, but it also boasts some pretty amazing health benefits." Read more: https://draxe.com/maitake-mushroom/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5696) People really want their dogs to chill out with CBD and demand is sky high
Date:
July 26, 2018 01:53 AM
CBD is being used by children and adults across the nation. Scientists have proven that it has an immaculate number of health benefits, even stopping seizures in children when nothing else worked. Now, pet owners are reaching for CBD to stop their dogs anxiety and hyperactivity at rates so high it is not easy to keep the product on the shelves. CBD is all-natural, has instant results and has proven itself worthy of use time and time again and pet owners are thrilled with the results Key Takeaways:
"BarkShop became the first online retail retailer to sell CBD products to dogs in March." Read more: https://mashable.com/2018/07/23/barkshop-cbd-products-for-dogs/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5674) Legal Pot States Expanding? Vermont House Approves Recreational Marijuana Bill
Date:
May 09, 2017 06:44 PM
By a narrow margin, Vermont voted to allow recreational cannibas use in a vote on Tuesday. It will be legal for adults over 21 to possess one ounce of marijuana as well as allowing a limited amount of plants that can be grown at home. Vermont has been varied it it's attitude towards marijuana, expanding medical marijuana use as well as pardoning prisoners convicted of crimes related to marijuana. The governor believes it is something the state should consider, but not at this time. Read more: Legal Pot States Expanding? Vermont House Approves Recreational Marijuana Bill
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4576) What is CBD? The Everyday Guide to Cannabidiol
Date:
January 01, 2017 11:19 PM
CBD, which is rapidly gaining popularity, is known for its immense healing properties that are just being discovered as scientific research into the cannabis plant expands. "CBD is quickly Expanding beyond the medical marijuana community and into totally new demographics. This rapid growth is certain to continue as more and more individuals discover how CBD can play a positive role in their own healthcare outcomes," said Patrick O'Malley, President of Good Life Colorado. Dr. Noel Palmer, Ph.D., The Chief Scientist at Mary's Medicinals, is equally enthusiastic the excitement around CBD, "CBD has amazing therapeutic efficacy for a large variety of conditions, but it doesn't get you stoned. For those who want a plant-derived medicine, CBD is an great option with very few negative side effects." Key Takeaways:
"As America's fastest growing industry, the legal cannabis industry is navigating unchartered territory by producing and selling products made from a versatile plant that has been in the shadows for the last 80 years." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3729) What Is The African Mango Diet?
Date:
September 16, 2014 08:16 PM
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3158) Anemia Causes, Prevention And Supplements.
Date:
August 07, 2014 05:22 PM
Causes of anemia Causes include loss blood, unreasonable destruction of red platelets or inadequate creation of red platelets. Insufficient creation of red platelets is the most widely recognized class of pallor, and poor sustenance is the most well-known reason. The most successive sorts of supplement inadequate sickness are those identified with an insufficiency of iron, folic corrosive (vitamin B9), copper or vitamin B12. Iron insufficiency pallor is frequently seen in babies more youthful than two years of age, adolescent young ladies, pregnant ladies and the elderly. This kind of weakness incorporate elements connected with poor dietary admission of iron, an expanded requirement for iron, diminished iron assimilation, blood misfortune or a consolidation of these circumstances. Folic corrosive is the most as often as possible discovered vitamin lack on earth. The gatherings of individuals well on the way to have folic corrosive insufficiency are dipsomaniacs, individuals with mal-ingestion conditions or perpetual loose bowels and pregnant ladies. A folic corrosive insufficiency can likewise cause despondency, the runs and a swollen, red tongue. Copper inadequacy is exceptional, be that as it may, it can happen in individuals who take a zinc supplement without Expanding their copper admission in light of the fact that zinc can meddle with copper ingestion.  How to prevent anemia?To avoid you have to consume overall adjusted dinners including iron rich nourishment. In the event that you have weakness, keep away from refreshments and sustenance holding juice, it meddles with the body's capacity to ingest iron. Maintain a strategic distance from tannins, they additionally hinder iron ingestion and nourishment high in oxalic acids; which incorporate almonds, asparagus, beans, beets, cashews, chocolate, kale and rhubarb. While most instances of pallor are created by straightforward nourishment lacks, it can additionally be an indication of a more genuine restorative issue. The best way to get a clear judgment of sickness is to get a blood test. In the event that you think you have iron deficiency, don't start a supplement program until you have a finding from your doctor. Supplements Iron - helps avert iron insufficiency weakness. Take 30 milligrams fumarate, gluconate or succinate press twice a day between dinners. In the event that this reasons stomach trouble, switch to 30 milligrams with suppers three times each day. Folic corrosive (vitamin B9) - aides anticipate iron deficiency brought about by folic corrosive inadequacy. Take 800 to 1,200 micrograms three times every day. Vitamin B12 - aides anticipate vitamin B12 inadequacy pallor. Take 2,000 micrograms sublingual (set under the tongue) three times every day for 30 days, then 1,000 micrograms methylcobalamin (the dynamic type of B12) once a day, in addition to folic corrosive. Vitamin C - helps the body assimilate iron. Studies have demonstrated that you can almost twofold your ingestion of iron from plant sources by devouring vitamin C with the iron. Take 1,000 milligrams 3 times each day with dinners. Vitamin B5 (pantothenic corrosive) - assists with the creation of red platelets. Take 100 milligrams every day. Vitamin B6 (pyridoxine) - assists with the creation of red platelets. Take 50 milligrams 3 times each day.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3154) A Sulfur Supplement Is Necessary For A Healthy Body
Date:
May 17, 2014 01:25 AM
The human body obliges sulfur for bones, joints and an assortment of capacities. Sulfur is needed for ordinary day-by-day capacities and in bigger amounts when the body's frameworks are focused on, repairing harm or battling a malady. A sulfur supplement is required that can likewise offer a large number of numerous wellbeing upgrading profits for fighting an extensive variety of wellbeing issues, Expanding imperviousness to sicknesses, and making wellbeing and prosperity. It is additionally required for detoxification of the body in uprooting poisons and mechanical chemicals that the body regularly assimilates once a day. An approach to fulfill these needs is with a day-by-day admission of MSM (Methyl Sulfonyl Methane). MSM is the main bio available manifestation of sulfur, a macro mineral that is utilized within critical sums in the body. An uncommon dietary supplement is likely the most noteworthy finding since Vitamin C, and is presently the most prominent supplement in nourishment. It is intended to help joint conditions, for example, osteoarthritis, sprains, tendinitis, bursitis and games related wounds. It is non-poisonous, non-allergenic and does not meddle with different sorts of pharmaceuticals and supplements, and offers a long arrangement of wellbeing profits for the body. Where to find sulfur? Sulfur is fundamental in the ordinary consistently working of the human body. It has been utilized for many years to cure skin sicknesses, joint and bone conditions and numerous different afflictions. In spite of the fact that sulfur is gotten from nourishment sources and the human body does not handle it, in instances of great insufficiency it could be acquired by dietary supplements. Sulfur makes up pretty nearly 0.25% of body weight and is a vital some piece of all living cells. It is key in the counteractive action of numerous issues and must essentially be acquired from sustenance or wellbeing supplements. Sulfur could be found in numerous skin balms, bar soaps, salves and creams. It is been demonstrated to be valuable in the medicine of pimple inflammation. It is utilized as an element within the medication for other skin related issue, for example, scabies, warts, and likewise for dandruff because of the antifungal, antibacterial properties of sulfur. Results of sulfur have been utilized to upgrade the procedure of wound recuperating, which was its motivation in the Trojan wars.
MSM is the wealthiest wellspring of natural sulfur accessible and is essential in the creation and recovery of tissue. It is found in and utilized by every cell as a part of the body. It expands vitality, readiness, mental placidness and improves the capacity to focus. It remembers the manifestations of joint pain, carpal tunnel, tendonitis, bursitis and unending weakness. Sulfur has an alternate, positive impact on all the frameworks in the human body. MSM causes quick detoxification of the body's tissues by making the cell dividers more porous, making it simpler for the body to ingest supplements and to dispose of poisons by flushing them out of the body. Hormones, compounds, antibodies and cell reinforcements rely on upon MSM for their day-by-day capacities. MSM is a non-medicine supplement that can help with joint issues running from a slight solidness to extreme torment. Its general profits helps with wellbeing issues, for example, joint inflammation, unfavorable susceptibilities, gastrointestinal, PMS, skin break out, lung issues, muscle torment, parasite, a few diseases, heart smolder and blockage, to name a couple. It is an exceptional dietary supplement that could be utilized for a mixture of requisitions, for example, hostile to aggravation, body corrosive decrease, Expanding flow, sound connective tissues, lupus, breast and colon diseases, diabetes, eye wellbeing, anxiety and mental issue. Studies have indicated that MSM Capsules help joint adaptability, decrease firmness and swelling, and diminish torment connected with maturing and damage. They have been utilized to help with ceaseless agony, joint inflammation, joint irritation, rheumatoid joint pain, osteoporosis, bursitis, tendonitis, musculoskeletal ache, muscle issues and then some. These containers can make the skin look more youthful and increment vitality levels. MSM is copious in nature, yet the wealthiest characteristic sources just give it at levels of a few parts for every million. Nourishment sources are prepared which exhausts characteristic sulfur, making a MSM supplement vital, and these containers have not demonstrated any negative reactions.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3119) Does Coral Calcium Alkalize The Body?
Date:
March 19, 2014 07:59 PM
What is coral calcium
Benefits of coral calcium Calcium is a mineral we essentially need to have consistently, to keep our bones, teeth and nails solid, and avoid osteoporosis as we get more established. Notwithstanding upholding solid bones, calcium is fundamental in the sound working of the circulatory and sensory systems. Calcium is likewise crucial for fitting blood thickening. Calcium is 35% of our physique's mineral cosmetics and our first mineral. Incorporate these key minerals to your eating methodology today. What's more not at all like other calcium supplements, coral calcium does have exceptional properties that make it worth determinedly acknowledging as a supplement to your day by day diet.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3068) CLA in Weight Loss
Date:
January 21, 2014 10:05 AM
What is CLA
Scientists accept CLA helps square fat cells that are in the figure from topping off with fat by meddling with a fat-archiving compound regarded as lipoprotein lipase, and additionally, by Expanding the affectability of units to the hormone insulin. Creature studies have likewise demonstrated an expansion in lean bulk and fat lessening, or fat blazing; furnishing positive progressions to form sythesis, a decline in general muscle to fat ratio ratios. It is known as a "fat eliminator" on the grounds that it revs up muscle metabolism, in this way, helping increment lean tissue, bringing about the figure to need more calories to capacity (since fat units smolder next to zero calories), accordingly accelerating the fat smoldering procedure to make vigor.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2977) Glycolic Acid
Date:
December 19, 2013 07:34 AM
Glycolic acid acts as a remover of the “glue” holding the dead cells together. This property helps it to exfoliate the dead cells of the skin tissue. Handles acne After this removal, the skin remains softer, smooth and improves in appearance. This inhibits cell from building-up on the skin, which brings about a non-appealing complexion and blocked pores which cause acne. Oily skin has a low ability to exfoliate the dead skin cells hence requires the implementation of glycolic acid to help prevent whiteheads and blackheads. Kills scars Glycolic acid also helps peel away the scarring cells. This helps to reduce the scars hence a well and uniformly pigmented skin tone. Glycolic dermatology medicines likewise help to diminish skin aggravation by advertising the early evacuation of flanky, dryskin units and Expanding the damp substance of the skin. This helps equalization of the sebum generation in the skin. Over abundance and trapped sebum in the skin can accelerate stopped up pores, decreased peeling and skin aggravation in skin break out. Dampness is critical for solid, adjusted skin cells from all skin sorts, considerably oilier appearances. Other Glycolic Acid Considerations Those who are utilizing healthy skin pharmaceuticals, for example, Accutane or Retin-A, might as well dependably counsel with their dermatologist or therapeutic supplier before utilizing glycolic harsh corrosive healthy skin items. Furthermore, those under the consideration of a specialist for skin issue, for example, rosacea, skin inflammation or dermatitis, may as well additionally counsel with their medical practitioner before beginning a glycolic harsh corrosive skin health management schedule. References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2930) Is Pycnogenol a Good Antioxidant?
Date:
April 01, 2011 03:10 PM
Pycnogenol And Your HealthPycnogenol is the latest innovation in the antioxidant supplement industry. It makes use of oligomeric proanthocyanidins, select bioflavonoids, and organic acids that have been well investigated in a span of more than 30 years. As a trademarked product, it has been cited in more than 230 published works and systematic reviews that came into the conclusion that it is safe and effective. In fact, it is now an ingredient in over 300 health products. Pinus pinaster is an indigenous plant species of western Mediterranean from which the patented pycnogenol is extracted from. It is most populous in southwestern France, but it can also be found in large numbers in Portugal, Spain, Italy, and Morocco. Unlike new ingredients in some dietary supplements, pycnogenol is all-natural and completely derived from the Maritime Pine, which may well be known in the now-obsolete scientific name Pinus maritima. Neutralizes Reactive Oxygen Species Fast Antioxidants work on the principle of replenishing the antioxidant reserves of each cell especially at times when our body is most susceptible to physical fatigue. Radical chemistry has taught us that reactive oxygen species, or ROS, are natural by-products of oxygen metabolism. There is nothing we can do to inhibit their releases, but our body does have a mechanism to neutralize them. Free radicals are one of the best known ROS and they are particularly reactive, causing a damaging chain reaction called oxidative stress. What makes pycnogenol different from other antioxidant supplements? It is the fastest-acting antioxidant out there with an absorption rate of only 20 minutes. In contrast with other known antioxidants, such as vitamin C and vitamin E, pycnogenol is believed to readily cross the blood-brain barrier, Expanding its uses in the central nervous system. This is the reason why it has been suggested to be of value in treatment of known disorders of the nervous system. More importantly, it works up to a record-high 72 hours before it gets excreted by the body.
Fight Inflammation and Cardiovascular Disease With PycnogenolDisplays Potent Anti-Inflammatory Activities There have been numerous citations that pycnogenol is an effective inhibitor of inflammation intermediaries. It is postulated that it influences the productions and releases of eicosanoids that govern inflammatory responses. It has associated with the treatment of osteoarthritis, and preliminary results are encouraging. Also, it is believed that pycnogenol interferes with the effects of histamine via its receptors, and acts on mast cells responsible for mediator release. This is the reason why it is widely accepted as a viable treatment option for asthma, multiple sclerosis, allergic rhinitis, acute dermatitis, atopic eczema, and other skin conditions. Contributes to Overall Circulatory Health Pycnogenol is one of the antioxidants under scrutiny for its medicinal potential in the prevention of major diseases that afflict the circulatory and cardiovascular systems. For one, it has been observed to significantly lower systolic blood pressure, making it an effective therapy for hypertension. It has shown to alleviate chronic venous insufficiency and remove varicose veins. Moreover, regular supplementation of pycnogenol appears to improve performance in endurance athletes. Pycnogenol is an excellent herb to add to anybodies diet. Give Pycnogenol a try today!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2264) Now foods and GMP Practices
Date:
February 04, 2010 12:36 PM
Author: Michael Lelah, Ph.D, Technical Directory, Now Foods It should come as no surprise that 2009 was a challenging year with regard to the timeliness of order delivery, not just at NOW, but on an industry-wide scale. Many of the brands you carry have not been able to meet your demands. In 2009 all medium-sized dietary supplement manufacturers, including NOW Foods, were officially required to meet the FDA's new dietary supplement cGMPs (current good manufacturing practices). NOW has placed very high quality standards on our products, and has been certified by NPA's stringent GMPs since 2000. Now that the FDA has started auditing manufacturers in our industry, we have found that the FDA requirements for the cGMPs are more strict than the early interpretations of experts. This has resulted in ourselves and our industry being less prepared than anticipated, affecting the order fulfillment rates of many companies. We are actively working to respond to this. Let's review the new FDA cGMPs. Good Manufacturing Practices, or GMPs, are manufacturing control systems designed to ensure that health products are manufactured in a consistent and safe manner. Standard operating procedures, specifications for all ingredients and products, and lab testing are cornerstones of GMPs. The FDA cGMPs are considerably rigorous, and by the FDA's own estimates, 25% of the brands you carry could be out of business as a result of not being able to meet their new cGMPs. Moreover, even for reputable brands, there is a lack of clarity on what the FDA expects, as much of this is new. You might be wondering what all of this has to do with your orders? We at NOW Foods, along with other reputable manufacturers have increased our quality control efforts to meet the new FDA cGMPs. There are more requirements for ingredients and finished products, more documentation and more testing. The breadth of NOW's product line requires testing of thousands of ingredients. Based on the extensive nature of these efforts, coupled with disruptions in the supply chain, your orders have most likely been affected. We are now better prepared to serve you. We are taking the safety of our products to entirely new levels and doing everything in our power to expedite the delivery of NOW products to your door. Here are just a few examples of what we're doing:
Here's what you can expect from NOW Foods in 2010:
At NOW Foods we are continuing to work hard to meet your needs, despite the increased challenges to our supply chain. We hope and anticipate that as we move into 2010, you will reap the benefits of our quality and fulfillment efforts.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2123) Pine Bark Extract Boosts Nitric Oxide Production
Date:
January 17, 2008 03:24 PM
A recent study has found that Pycnogenol, which is an antioxidant plant extract from the bark of the French maritime pine tree, helps individuals by enhancing the production of nitric oxide (NO), which in turn leads to an increase in blood flow and oxygen supply to muscles. Nitric oxide is a key cardiovascular chemical that is produced by the body. It increases blood flow which allows more nutrients and oxygen to be delivered to the muscles. This helps muscles to cope with increased physical activity. The study also suggests that taking Pycnogenol provides more NO in response to neurotransmitters which allows for better expansion of arteries, which can then carry more blood. This process meets the enhanced oxygen demand of muscles and helps to avoid anaerobic metabolism. The results of this study also lead researchers to believe that Pycnogenol can be a natural alternative therapy in diseases involving oxidative stress. The study was held at the Hiroshima University Graduate School of Bio-medical Sciences in Japan. Each day for two weeks, healthy, young men were given either 180 mg of Pycnogenol or a placebo. In order to identify Pycnogenol's effect on the release of nitric oxide, patients were infused with an inhibitor of L-arginine, which restricts arteries from Expanding in response to the neurotransmitter acytelcholine. After two weeks of supplementation, the results revealed that blood flow had increased by forty two percent. Additionally, the group receiving a placebo did not show a significant blood flow increase at all. NO causes the muscle surrounding the arteries to relax, resulting in an increase in the diameter of the blood vessel, while acetylcholine stimulates the cells of arteries to produce NO from L-arginine faster. When the subjects being tested had taken Pycnogenol, the arteries relaxed and blood flow increased by Fourty two percent, as compared to the placebo group. Although more research is warranted, this breakthrough is especially encouraging to athletes since Pycnogenol seems to allow people to move faster when they are exercising. It does this by satisfying the enhanced muscle oxygen demand and also increases the blood flow to the active muscles. People who are performing heavy physical activity experience the release of acetylcholine by nerves to arteries that are supplying the active muscles. This acetylcholine makes them expand, while the whole process requires that there is an enhanced production of nitric oxide. A great variety of studies about Pycnogenol and sports nutrition have been conducted over the past years. The most recent one occurred a year ago. In this study, Pycnogenol was found to improve blood circulation even in extended aerobic muscle activity. Pycnogenol also enhanced sports endurance be alleviating the cramping and muscular pain that occurs in the majority of athletes. To sum it up, Pycnogenol is not only effective for enhancing and prolonging the performance of muscles during support, but it also supports muscle adaptation to a higher workload and allows the body to recover from physical faster. When shopping for a good pycnogenol supplement, look for a standardized extract that guarantees that each capsule or tablet contains a specific amount of active ingredients per serving, otherwise you might be purchasing something that is ineffective.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1692) The Awesome Foursome: Coenzyme Q10, D-Ribose, L-Carnitine, and Magnesium
Date:
May 18, 2007 01:06 PM
The Awesome Foursome: Coenzyme Q10, L-Carnitine,
D-Ribose, Magnesium
The “Awesome Foursome” of Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium helps our hearts metabolize energy more efficiently and protects them from the stress of cardiovascular disease. This powerful combination of nutrients goes directly to the basic biochemistry of cellular energy metabolism. Now let’s take a closer look at how Coenzyme Q10, L-Carnitine, D-Ribose, and magnesium work in synergy to promote cardiovascular health.
Coenzyme Q10:
Energy Recycling through the Electron Transport Chain
Coenzyme Q10 is a powerful antioxidant that helps protect the mitochondrial membrane, mitochondrial DNA, and cell walls from free-radical attack. But its most important function in the body is its central role in energy metabolism.
Most – about 90 percent – of the ATP used by cells is recycled as food (fuel) and oxidized in the mitochondria. Fatty acids, carbohydrates, and, occasionally, proteins are carried across the mitochondrial membrane and enter the Krebs’ cycle, moving from step to step and spinning off electrons. These electrons are then handed off to the electron transport chain, where, in the presence of oxygen, the energy from the electrons is captured as a phosphate group is added to ADP to form ATP. This recycling of ATP is called oxidative phosphorylation, and the by-products of these pathways are CO2 and water.
In this fashion, Coenzyme Q10 acts as a gatekeeper of electrons, making sure they are carried to just the right place to pass on their life-giving energy.
What is critical, however, is the simple fact that without Coenzyme Q10 the electron transport chain would totally break down. And since the electron transport chain is (by far!) the largest contributor to cellular energy turnover, its loss would be catastrophic. It is also important to know that there has to be an excess of Coenzyme Q10 in the mitochondria to be maximally effective. Having just enough isn’t sufficient to do the job properly, and having a deficiency seriously affects the mitochondria’s ability to supply the cell with energy.
Cellular stress can cause Coenzyme Q10 deficiency, which places a severe strain on Coenzyme Q10 availability. People with heart disease, hypertension, gingival disease, Parkinson’s disease, and the other disorders we’ve discussed are known to be deficient in Coenzyme Q10. Whether these deficiencies are the cause or the effect of these varied medical problems, the end result is that they sap the life out of their mitochondria and reduce their energy supplies. You see, Coenzyme Q10 cannot function properly if electrons are not coming out of the Krebs’ cycle, and the Krebs’ cycle won’t work without the fuel that’s transported into the mitochondria by L-Carnitine.
L-Carnitine:
Transporting the Cellular Energy Fuel
Fatty acids are the preferred energy fuel for hearts and most other cells in the body. L-Carnitine facilitates the beta oxidation of fatty acids as energy fuel. And since fatty acids are the preferred fuel for energy recycling in cells, this action is critical to cell and tissue function. Unfortunately, L-carnitine is deficient in people with heart disease, peripheral vascular disease, lipid metabolic disorders, mitochondrial disorders, and many other disease syndromes we reviewed earlier. This L-carnitine deficiency disrupts the normal metabolism of fatty acids, reducing available energy supplies and leading to the accumulation of toxic by-products of fatty acid metabolism. L-carnitine supplementation revives fatty acid metabolism and restore normal mitochondrial function. But even this powerful improvement in cellular energy metabolism cannot up for the energy drain that comes from the loss of energy substrates caused by low oxygen delivery to the tissue. Only D-Ribose can do that.
D-Ribose:
Rebuilding the Cellular Energy Pool
As long as cells and tissues have plenty of oxygen, the pool of energy substrates in the cell remains high. And as long as there is enough L-carnitine and Coenzyme Q10 available, the process of energy utilization and supply can proceed unimpeded. However, the cellular supply of oxygen can be restricted by acute or chronic heart disease, peripheral vascular disease, any number of skeletal – or neuromuscular diseases, or even high-intensity exercise.
When cells are deprived of oxygen the mitochondrial energy turnover becomes inefficient. Remember, oxygen is required to let the oxidative pathway of energy recycling work properly. If the mitochondria are not able to recycle energy efficiently, cellular energy supply cannot keep pace with demand. But the cell has a continuing need for energy so it will use all its ATP stores and then break down the by-product, adenosine diphosphate (ADP), to pull the remaining energy out of this compound as well. What’s left is adenosine menophosphate (AMP). Since a growing concentration of AMP is incompatible with sustained cellular function it’s quickly broken apart and the by-products are washed out of the cell. The net result of this process is a depletion of the cellular pool of energy substrates. When the by-products of AMP catabolism are washed out of the cell, they are lost forever. It takes a long time to replace these lost energy substrates even if the cell is fully perfused with oxygen again.
Ribose is the only compound used by the body to refill this energy pool. Every cell in the body has the capacity to make ribose, but hearts, muscles, and most other tissues lack the metabolic machinery to make ribose quickly when the cells are stressed by oxygen depletion or metabolic insufficiency. Ribose is made naturally in the cells from glucose. In stressed cells, however, glucose is preferentially metabolized for the energy turnover and is not available for ribose synthesis. So when energy pools are drained from stressed cells, the cells must first wait for the slow process of ribose synthesis before they can begin to replace their lost energy stores.
Acute ischemia, like that which takes place during a heart attack, heart surgery, or angioplasty, drains the cell of energy. Even when oxygenated blood flow returns, refilling the energy pool may take ten or more days. But when oxygen deprivation is chronic, or when energy metabolism is disrupted by disease, there may be so much continual strain on the energy supply that the pool can ever refill without the assistance of supplemental ribose. Conditions like ischemic heart disease or congestive heart failure fall into this category. In these situations, supplementing the tissue with exogenous ribose is the only way the cell can keep up with the energy drain.
Magnesium:
Switching on the Energy Enzymes
Magnesium is an essential mineral that's critical for energy requiring processes, in protein synthesis, membrane integrity, nervous tissue conduction, neuromuscular excitation, muscle contraction, hormone secretion, maintenance of vascular tone, and in intermediary metabolism. Deficiency may lead to changes in neuromuscular, cardiovascular, immune, and hormonal function; Impaired energy metabolism; and reduced capacity for physical work. Magnesium deficiency is now considered to contribute to many diseases, and the role for magnesium as a therapeutic agent is Expanding.
Magnesium deficiency reduces the activity of important enzymes used in energy metabolism. Unless we have adequate levels of magnesium in our cells, the cellular processes of energy metabolism cannot function. Small changes in magnesium levels can have a substantial effect on heart and blood vessel function. While magnesium is found in most foods - particularly vegetables - deficiencies are increasing. Softened water and a trend toward lower vegetable consumption are the culprits contributing to these rising deficiencies.
Supporting the Links in The Energy Cycle Chain – the Synergy
Clearly, each membrane of the “Awesome Foursome” is fundamental to cellular energy metabolism in its own right. Each plays a unique and vital role in supplying the heart with the energy it needs to preserve its contractile force. Each is independently effective in helping hearts work through the stress of disease. And while each contributes immeasurable to the energy health of the cell, in combination they are unbeatable. Allow me to reiterate the step-by-step, complicated cellular processes involved to be sure that you really understand the rationale for using these nutrients.
The cell needs a large, sustained, and healthy pool of energy to fuel all its metabolic functions. Contraction, relaxation, maintenance of cellular ion balance, and synthesis of macromolecules, like proteins, all require a high energy charge to carry their reactions to completion. The energy pool must be preserved, or these fundamental cellular functions will become inefficient or will cease to operate altogether. To keep the pool vibrant and healthy, the cell needs ribose. But even with supplemental ribose, the cell needs the efficient turnover of its energy stores to balance ongoing energy utilization with supply. That’s where CoQ10 and L-carnitine come into play.
The converse is also true. Even if the cell is fully charged with energy, cellular energy supply will not keep pace with demand if the mitochondria are not functioning properly. CoQ10 and L-carnitine work to keep mitochondrial operations running at peak efficiency, and one side cannot work effectively without the other. Even though CoQ10 and L-carnitine can make the energy turnover mechanisms work more efficiently, they cannot increase the cell’s chemical driving force, and their action will be only partially effective. Ribose on the other hand, can keep the energy pool supplied with substrate, but the value of energy pool repletion cannot be fully realized if the substrate cannot be maximally utilized and recycled. Ribose fills the tank; CoQ10 an L-carnitine help the engine run properly.
Magnesium is the glue that holds energy metabolism together. By turning on the enzymes that drive the metabolic reactions, magnesium allows it all to happen.
These four nutrients must be utilized by cardiologists and other physicians as they treat patients day-to-day. On my own journey, using Coenzymes Q10 for two decades, L-carnitine for more than ten years, D-Ribose for two years, and magnesium equally as long, I’ve seen this “Awesome Foursome” reduce suffering and improve the quality of life for thousands of patients.
The future of nutrition in conventional medicine is very bright, although the integration of nutritional supplements has been a slow and, at times, lonely process.
L-carnitine and Coenzyme Q10 are finally gaining the recognition they deserve. D-Ribose is emerging as a new player in the complex understanding of metabolic cardiology, and doctors are beginning to discuss the important role of magnesium deficiency in heart patients. As a practicing cardiologist for over thirty years, I see metabolic cardiology as the future for the treatment of heart disease and other complex disease conditions, as well.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1539) What are you really Getting?
Date:
August 21, 2006 05:20 PM
Supplement labels can be confusing!
The list of ingredients on some supplement labels can tax the mind of even a Ph.D. in nutrition! What’s worse, although labeling laws exist to counter misleading and non-uniform labeling, confusing and deceptive labeling, confusing and deceptive labeling practices continue to abound. Here’s some help to aid you in making better sense of supplement labels.
1.Begin at the Bottom
The supplement facts panel on the label of every nutitional supplement sold in the
2.Directions, Dose & Value
Directions: Though not required on labels, directions tell how and when to take supplements. This is important because timing your doses can affect absorption. In general:
· Vitamins are best absorbed when taken with food, and in divided doses throughout the day.
· Fat-soluble vitamins (A,D,E,K) require dietary fat for absorption, so are best taken with meals.
· Many minerals can be absorbed effectively at any time.
· Most herbs, probiotics, amino acids & proteolytic enzymes (not digestive enzymes, which should be taken with meals) are best taken on an empty stomach.
1. Serving size: SERVING SIZE is required on labels. It recommends the number of tablets, capsules, spoonfuls, ect. Taken at one time. Be ware that a serving is not necessarily the total recommended daily amount.
2. Cost-Effectiveness: To determine, first find the SERVING SIZE. Then read the directions to see how much servings are suggested daily. Finally, divide the number of servings needed into the number of SERVINGS PER CONTAINER.
Example: Assuming the two bottles above have the same ingredients and cost. The product on right offers more servings, and is a better buy. Product on left just has less nutritive ingredients, or more filler, in each pill.
3. % DV (Daily Value): The daily value of a nutrient represents the amount expected to meet the daily needs of an “average” healthy person. On labels, % DV indicates provided by one serving. DVs have not been established for herbs, essential fatty acids and other nutrients.
Note: Many experts in nutrition think that suggested DV levels for some nutrients are far too low to optimize health. This is why certain ingredients may be present at greater than 100% DV levels.
3.Games Labels Play
There is no free lunch in the world of supplements. A bottle that costs less probably contains less – either fewer nutrients, or less effective forms of nutrients. Educate yourself; compare ingredient amounts, forms and sources, and watch out for labeling tricks such as these.
“Padding” the label
“padding” the label is a common way for supplement marketers to make their ingredients list look more complete and beneficial than it really is. Padding methods include:
Example: CoQ10 useful range is 30mg to 400mg (milligrams.) product on left provides 1000mcg (microgram) of CoQ10, the equivalent of just one mg! product on right provides a beneficial 50mg.
Example: Whole grains such as oats are part of a heart healthy diet, but the product on left provides less than a pinch 20mg of oat bran. Product on right includes no irrelevant ingredients in useless amounts.
Example: Fiber and flavonoids are part of oats, not more ingredients.
The “Name’s the Same” Game
A common trick is to provide unproven, weak or useless forms of familiar, good ingredients. Buyer beware!
Example: Studies suggest that Pygeum bark standardized extract helps support prostate health. Product on left uses unresearched powdered bark.
Proprietary Blend = “It’s a Secret”
Some companies may hide the quantity and quality of their ingredients by calling their formula a “Proprietary Blend.” This term may allow manufacturers to use a lot of nutrient from a cheap source and very little from a good source without disclosing how much of each you are actually getting.
This deceptive practice is legal—as long as the secret blend:
· Is labeled “Proprietary Blend” (or fanciful trademark name)
· Lists individual nutrients in descending order by weight
· Lists the total weight per serving
When you see the word “Proprietary,” ask: “how relevant is the first or second ingredient?” Sometimes, the most abundant ingredients are either fillers, or inexpensive, less effective forms.
Example: Legally, product on left could contain 99% alfalfa filler and only 1% of all the other herbs together! The Good Label tells all.
Hiding Outside the Box
Another clever way to hide the quality of ingredients is by listing them outside the Supplement Facts box, in the Other Ingredients section located beneath the box. This section is usually intended for listing agents used in the tableting or encapsulation process.
Example: Agents used in supplement manufacture (i.e. cellulose and stearates) should be listed under Other Ingredients. Product on left also uses this section to list catchy sounding spirulina, lycopene, and grape seeds. With no amounts listed, assume these ingredients are present in low levels that provide little value. A supplement maker who is proud of a product’s nutritive ingredients will fully disclose amounts within the Supplement Facts box not list these ingredients along with manufacturing agents in the Other Ingredient section.
4.Understanding Herbs
Herb Forms: Powders, Tinctures, Extracts
The form, preparation and concentration of an herb affects its potency and influences the herb’s potential for therapeutic effectiveness. the potency of all herb forms except standardized extracts are uncertain and depends on factors invisible to the consumer (i.e. soil quality, rainfall, seasonal climate, harvesting methods, storage methods and age).
Know Your Plant Parts: Medicinal plants often have specific parts that are most effective therapeutically, such as the root for goldenseal, the leaf for raspberry, and the blossom for clover. Products using irrelevant plant parts may cost less, but offer little or no benefit!
Powdered Herb
Often encapsulated or used as tea, powdered herbs are more likely than other forms to lose potency when exposed to air. Fresh, high quality powdered herb may add therapeutic or nutritional value to a supplement. Low quality powders may provide little benefit. Look for expiration or “use by” dates.
Example: If the label doesn’t say otherwise, assume the form of herb is powdered. Better labels specify plant part and latin name (genus and species). Sometimes a less effective species of a plant is used to save money. Check to see if other related species may be equally effective.
Tinctures and Fluid Extracts
Tinctures contain the soluble parts of dried or fresh herbs, often extracted in a mixture of alcohol and water, vinegar or glycerin. Tinctures are usually dispensed by drops. This form is more stable and thus has longer shelf life than powdered herb.
Example: Better labels specify tincture strength as a ratio. Regular tinctures are made using 1 or 2 parts herb to 10 parts solvent, yielding strength ratio of 1:10 or 1:5. higher potency tinctures (also known as fluid extracts) use more herb in less solvent, yielding stronger 1:3, 1:2, or even high strength 1:1 ratios.
Concentrated and standardized extracts
Concentrated or standardized extracts (solid, powdered, liquid) are generally prepared from evaporated herbal tinctures or teas.
Example: A better label tells you the concentration strength by noting the ratio of herb to extract. This is often appears after the plant name.
Example: Standardized extracts provide a set percentage of an herb’s researched nutritive ingredient. Useless this percentage is noted on the label, the term “Standardized” is meaningless.
5.Beware of False Claims
Is it science of is it marketing? To avoid being misled, question all claims on supplement labels as well as in advertisements. Although government guidelines restrict the types of claims that manufacturers can legally use to promote their products, not all companies comply. Many promises mount to little more than marketing hype.
Use common sense to decide if a claim seems realistic. Be aware of emotionally charged, misleading language in advertising.
When doubt, contact the company and request information to support a claim. Unbiased research and human studies are most relevant. If the science seems legitimate, verify that the form and dose used in product match form and dose showing benefit in studies.
-- Buy Discount Vtiamins Vitanet ®
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1353) An Interview with Congressman Sam Farr, Representing California’s Central Coast.
Date:
May 30, 2006 02:36 PM
Ambassador to Health Profile An Interview with Congressman Sam Farr, Representing California’s Central Coast. Congressman Sam Farr, a fifth-generation Californian, represents the state’s beautiful central coast. His district encompasses the length of the big Sur coastline in Monterey County, the Monterey Bay National Marine Sanctuary, the Salinas Valley “Salad bowl,” the redwoods, mountains and beaches of Santa Cruz County, and the majestic rural landscape of San Benito County. The health and wealth of this region has been strengthened by Rep. Farr’s focus on the environment, education and the economy. Rep. Farr was raised in Carmel, California and graduated from Willamette University with a BS in biology. He later attended the Monterey Institute of International Studies and the University of Santa Clara. He is fluent in Spanish. As a tough advocate for the health food industry, he has lobbied for strict federal organic standards. Todd: Congressman Farr, thank you for taking the time to speak with us! Id also like to thank you for all the great things you’ve done for our community, form funding marine sanctuaries and authoring the Ocean’s Act to Expanding Pinnacles national Monument. The League of Conservation Voters and others have recognized you as an “Environmental Hero”. And, you’ve worked hard to support the economic vitality of central coast’s $3 billion agriculture industry which includes a substantial organic segment. Our backyard here is also the home of a robust group of nutritional supplement manufacturers. An estimated 187 million Americans are currently taking dietary supplements as part of their daily healthy diet. In California, we’ve got 792 natural product manufacturers and distributors. Where do you stand on the state of our industry? Congressman Farr: Well, thank you for the introduction and for asking to talk to me about nutritional supplement issues. I am very supportive of this industry and include myself in the 187 million Americans taking dietary supplements. I think supplements offer many safe and viable tools to maintain your health. The continued growth of this industry is an indication of both consumer confidence in the products and the products’ ability to fill the gaps where conventional medical care falls short. Todd: It is estimated that by 2030, more than 70 million Americans will be over the age of 65 and the cost of health care could reach $16 Trillion per year. A recent study by the Lewin Group showed that by taking certain dietary supplements, seniors can lead healthier, more productive, independent lives while saving billions in reduced hospitalizations and physician services. Do you share our view that a Wellness Revolution is needed to counter the dilemma of an aging population versus shrinking health care support in the future? Congressman Farr: Our health care system is definitely facing a challenge, especially as the Baby Boomers hit their 60’s and Americans are living longer than ever before. As a Baby Boomer myself, I am well aware of America’s aging population and the impact that will likely have not only on our social institutions but also our fiscal well-being. I agree that dietary supplements do play and will play an even larger role in the future as more seniors look for a way to augment their diets in order to stay healthy and active longer than past generations. Todd: Our industry is regulated by DSHEA (the Dietary Supplement Health and Education Act), which was passed unanimously by Congress in 1994 to create a reasonable regulatory framework for access to, information about, dietary supplements. But many say that the FDA and DSHEA weren’t adequately funded to do the job as tasked. “Supplements are unregulated” is a false argument we sometimes hear. To ensure that the FDA is able to carry out the law as Congress intended, Representatives Dan Burton (R-Ind.) and Frank Pallone (D-N.J.) introduced H.R. 2485, the DSHEA Full Implementation and Enforcement Act of 2005. Did you support this bill and where does it stand today? Congressman Farr: I think the DSHEA is a critical law and was proud to support it when Congress considered it in 1993 and 1994. I would certainly support H.R. 2485 if it came up for a vote in Congress. Unfortunately this bill has not moved since it was first introduced and referred to the Subcommittee on health in the house energy and commerce committee. Since this is an election year we have a tight schedule with only about 60 legislative days scheduled before we adjourn. That means it’s likely Congress will only finalize bills such as the appropriation bills that fund government before adjournment. Todd: Our business climate has included some valid and rigorous challenges to improve our industry, from good manufacturing practices (GMP), to allergy labeling, to implications of Prop-65 in California. It’s disconcerting that a new bill, H.R. 3156 The Dietary Supplement Access and Awareness Act would try to capitalize on misconceptions about the industry. In an era of declining health care and declining insurance coverage, this bill would regulate supplements as prescription drugs. Among other things, it would also require adverse event reports to be turned over to the FDA, even though other foods, including those with identical ingredients, do not have the same requirements. This has the potential to be the next Prop-65-like Lawsuit mill. The result of H.R. 3156 would be chilling. It will knock smaller producers out of the market. It will result in higher prices for all supplements. It will decrease the availability of health-giving supplements to the public. What’s your feeling on this? Congressman Farr: I am similarly concerned about H.R. 3156 and would oppose it if it came up for a vote in Congress. Like H.R. 2485, this legislation has been referred to a subcommittee on Health in the House Energy and Commerce Committee without any further action. The supplement industry has worked in good faith with the FDA since passage of DSHEA and H.R. 3156 would re-invent a wheel that isn’t needed. Instead, adequate funding as proposed in H.R. 2485 would provide ample oversight for the industry. Todd: According to a recent study, 72% of the general population believe the government should fund more research on health benefits of nutritional supplements. Do you agreen and what can be done to meet this need? Congressman Farr: I definitely agree that the federal government should play a bigger role in support of research regarding the health benefits of nutritional supplements. As a member of the House Appropriation Committee, I sit on the subcommittee that has jurisdiction over the FDA’s budget and I know the tight fiscal restraints the agency is under. I’ve worked with my colleagues to provide adequate funding, but it’s an uphill battle especially when we’re in a “robbing Peter to pay Paul” kind of situation. I recommend that people within the industry organize and use your consumer base to actively lobby Congress for additional funds. I’m fond of reminding people that the squeaky wheel gets grease – so let every Congress member and Senator know how much this issue matters to you. Todd: When there is overwhelming scientific evidence that nutritional supplements provides relief for a disease condition, it currently takes a lawsuit to get the FDA to relent and allow the claim. Even then, the FDA strictly limits the claim and requires a disclaimer that does more harm than good in communicating this important information to the public. There is a new bill, H.R. 4282, The Health Freedom Protection Act that would end FDA and FTC censorship of health information. As an example, the 50% of all adult males who suffer from an enlarged prostate could receive relief from that condition by consuming a simple and safe ingredient, saw palmetto derived from the fruit of the dwarf American palm tree. The FDA censors that information. The public deserves a better opportunity to be informed about omega-3 EFA and heart disease, folic acid and birth defects, phosphatidylserine and cognitive impairment. Do you agree and do you support this bill? Congressman Farr: I agree the public needs to access to the best information possible so they can make well informed choices about their health. I likely would support H.R. 4282 if it came up for a vote in Congress. Unfortunately this bill is in a similar situation as other we’ve mentioned in this interview – and again because of the tight schedule of an election year, it’s unlikely action will happen this year. Todd: According to the barometer study, 85% of the US population is currently using some type of dietary supplement. Do you? Looking at your busy schedule from co-chairing the House Oceans Caucus to your seat on the Travel and Tourism Caucus, you are one busy congressman! Are you popping nutritional supplements please tell us! Congressman Farr: I do take some nutritional supplements, though they vary and since Ginkgo Biloba isn’t among them I cant remember their names off-hand! One product I do use faithfully is Airborne to help me combat germs and colds that I might get from sitting on an airplane. But, like many Americans my life is over-scheduled and combined with the amount of air-travel I do, I find nutritional supplements helpful as I try to stay healthy despite my hectic lifestyle. Todd: Thank you Congressman Farr! Live long and prosper!
DSEA Release of Health/Cost Impact Study Conducted by the Lewin Group, Initial Results, Wash DC; Nov. 2, 2005 NNFA database. Adam.F on 3-15-06. DSEA Nutritional Supplement Barometer Study, 2005 Report, Prepared by the Natural Marketing Institute (NMI). Todd Williams; Source Naturals Marketing Programs Manager.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1288) Perplexed about Protein? immunoglobulins to boost the immune system.
Date:
April 29, 2006 01:58 PM
The Wellness RevolutionPerplexed about Protein? As protein and whey powders have advanced in popularity, the confusion about them has grown. In particular, protein processing technology has advanced by leaps and bounds; consumers are being presented with protein claims and counter-claims that are highly contradictory. The confusion is part of a rapid growth. Little Miss Muffet’s quiet dish of curds and whey has expanded from a minor sideline aid for weight lifters, with sales increases around to percent a year, into an explosive $1 billion a year industry, with some companies announcing sales growth of 110 percent in just the last year. The increase in market is from whey’s Expanding appeal. As new technology has made whey’s nutritive value beneficial to a wide range of consumers, more people are using whey, and whey is being added to more products. The problem is, those advanced nutritive qualities are not included in all whey products. The fantastic immune benefits, for example, apply to only the top tier of whey products. Protein Quality The standard of protein quality—the ability to provide indispensable amino acids—is judged on the basis of digestibility, nutrients, and amino acid composition. Whey has historically been acknowledged as on of the best sources of high quality protein. With the increasing popularity of whey, attention on new processing methods has raised the bar on quality, and new products have greatly expanded nutritional values. What may have been an acceptable high-quality whey protein a few years ago, no longer makes the grade. Tony Lucchesi, Natural Sales Trainer at Source Naturals says, “The different processing methods have changed the entire protein market.” He explains, “In separating casein from whey, (a process used to make cheese), most processing methods use heat, chemical modification, or pH adjustments. These all damage the native protein structure. The result is little or no biological activity in the whey product. All the low temperature drying and micro-filtration won’t help if the raw material is denatured before a protein is dried and brought to market.” Damaged Proteins Damaged protein may have been acceptable a few years ago, but it isn’t now. Lucchesi continues, “Animal experiments have shown that polypeptides—whole, non-denatured proteins—have greater nutritional value than protein isolates.” Protein isolates are what is left after the pasteurization process. The protein has traditionally been “Cross cooked” out of its normal balance. “What you have left are incomplete bits and pieces of whole protein,” he says. These protein bits have only partial nutrients. New Whey The latest introduction to the protein category are concentrates, which are intact, biologically-active whole proteins. The entire difference is in the processing; high heat, acids, and traditional methods of separating the caseins from the whey are no longer used. The new processing preserves the nutrients of the protein. This is the method that is the basis for a new Source Naturals whey product, True Whey. Lucchesi says, “TRUE WHEY is different in that it was designed to provide nutritional support for enhanced immune function. The entire process was designed for nutritive value. The preservation of these nutrients—lactoferrin, glutamine, immunoglobulins—give TRUE WHEY a huge benefit to athletes, children, and anyone interested in boosting their immune system.” Per serving, TRUE WHEY offers 8 grams of un-denatured protein that includes 900 mg immunoglobulins and 190mg of lactoferrin. Its vanilla flavoring has gotten very high reviews, and it has a two-year shelf life. It appears that the bar has truly been raised in the whey protein category!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1256) Gr-8 Dophilus
Date:
December 29, 2005 12:06 PM
Did you know that poor digestive function is a contributing factor in more than ninety percent of America’s serious health issues?! The waiting rooms of doctors are jam packed, in part because so many people are suffering with gastrointestinal problems. The medical establishment and alternative health and wellness practitioners don’t always agree, but both sides are certain that a healthy digestive system is the cornerstone of good health. Proteins, the building blocks of life; carbohydrates and fats, your body’s source of energy; vitamins and minerals; and water – all are assimilated through digestion. If you’re not properly digesting the foods you eat, your body isn’t obtaining the nutrients it needs to repair, renew and thrive. Without the raw materials it needs to repair the damage we do to ourselves every day, your body begins to break down, leading to poor health and accelerated aging2,3. While there are a multitude of factors involved in healthy digestive function, one of the most important is the delicate balance of bacteria found in the human gastrointestinal (GI) tract. There are three main types of flora in the human GI tract - Bifidobacteria, Bacteroides and Eubacterium. Of slightly less importance are Lactobacilli, Streptococci and Peptococci and other transitory flora1. Our stomachs and intestines are populated by hundreds of billions of these bacteria, or microflora. Amazingly, there are more probiotic organisms in our gut than there are cells in our bodies! That’s a lot of bacteria, but it’s GOOD bacteria, and each strain has specific functions in the human body. These bacteria aid the digestion of food and have protective qualities that contribute to good colon health. While a good balance of these different microflora is necessary, there are many factors that can, and do, disrupt this balance –certain medications, a poor diet, infection, stress, bad bacteria, aging and even the climate. The good news is a rapidly Expanding body of research suggests that supplementing the diet with the right mix of microflora can have a beneficial affect on gastrointestinal function, and therefore overall health. NOW® Gr8-Dophilus™ exclusively utilizes the finest strains from Rhodia Incorporated, the world’s leading supplier of high quality probiotic ingredients, and is enteric-coated to ensure that the bacteria in this product are not destroyed in stomach acid but reach the small and large intestines where they are most beneficial. Gr8-Dophilus is a vegetarian product that contains virtually no lactose. Lactobacillus acidophilus is a well-studied microflora species that’s highly resistant to gastric acidity and is able to proliferate in the presence of bile. Like many probiotic organisms, it also adheres well to intestinal cells, helping to prevent the adherence of certain enteropathogens5. Lactobacillus casei is a microflora strain that is found in the human mouth and intestines as well as in fermented vegetables, milk and meat. Recent research has shown that this bacterium is active in the GI tract and may help to modulate the immune system*. Research is continuing into this very promising probiotic. Lactobacillus rhamnosus, like Lactobacillus acidophilus, is highly resistant to gastric acidity and proliferates well in bile. It, too, adheres well to intestinal cells. We’ve included this particular strain because it works extremely well with L. acidophilus. Lactobacillus salivarius is a strain that has proven highly effective against Helicobacter pylori, a bacterial species implicated in a number of digestive conditions. Studies have shown that L. salivarius is capable of producing high amounts of lactic acid, which has been shown to inhibit H. pylori growth in live subjects. Compared to other Lactobacillus strains, L. salivarius was proven to have the greatest inhibitory effect on the proliferation of H. pylori,4 which is why this strain is included in Gr8-Dophilus™. Streptococcus thermophilus bacterium are isolated from yogurt and are recommended for lactose intolerant individuals to help digest lactose in the intestines. This strain is included in this formula to assist in the acidification of the intestinal environment, as well as to create a favorable environment for lactic acid bacteria. Bifidobacterium bifidum is one of the workhorses of the large intestine. It has a high tolerance to gastric acidity, and, like L. acidophilus and many other probiotic organisms, it adheres well to intestinal cells, helping to prevent the adherence of certain enteropathogens5. Bifidobacterium longum is a bifidobacterium of human origin that, like lactobacillus, is extremely resistant to gastric acid and bile salts. Because it’s anaerobic (able to live without oxygen) it’s perfectly suited to colonize the colon. Initial studies have shown that this particular strain of bifidobacteria helps to support the immune system*. It also seems to decrease enzymatic activity in feces. Researchers believe enzymatic activity in feces may contribute to carcinogenesis. Bifidobacterium lactis is one of the most well-studied strains of probiotic bacteria, with a wealth of peer-reviewed, published research on its benefits. Clinical trials on B. lactis have shown it to be helpful in a number of digestive conditions, including diarrhea and lactose intolerance, as well as immune response modulation.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1110) 8 Steps for Relieving Back Pain
Date:
August 02, 2005 02:02 PM
1. POSTURE. Don’t sit in the same position too long. Distribute your weight between your feet when standing. Always align your shoulders and head with your torso. Carry weight mostly with your legs and keep any held objects close to the body. 2. HERBAL RUBS. For muscle spasms, rub a mix of lobelia, myrrh and cramp bark extracts with a touch of cayenne into your back. They will act as muscle relaxants and pain relievers. Rub into aching area as needed. This mixture stores for approximately two years. 3. DEEP BREATHING. When you experience pain, your breathing becomes shorter and your muscles are more tense. Breathing deeply allows more oxygen to arrive to the affected area, helping it heal more quickly. Lie on your back, close your eyes and slowly breathe in and out as deeply as you can. Visualize your body Expanding and closing and the oxygen moving through your body to the muscles in pain. Continue this for 20–30 minutes. 4. MSM. MSM is a sulphur compound that can relieve pain associated with muscle cramps. It works by interrupting pain impulses heading to the brain. By taking 1,000 mg three times a day for one to six weeks, you should see marked improvement. 5. HEALTHY DIET. The food you eat affects every tissue cell in your body. Eat more fiber and drink more water. Limit your consumption of coffee, soda and other stimulants (they have an unnatural effect on the nervous system, which can lead to muscle disfunction). If you are overweight, you are adding extra strain on your back—a diet would be beneficial. 6. YOGA. Yoga is an excellent way to relieve muscle tension and promote strength and relaxation. Even trying two yoga poses daily should alleviate some back pain. 7. MAGNETS. A growing number of health professionals believe that magnets can help relieve back pain. Magnets reportedly encourage blood flow and reduce inflammation. In a recent study on the benefits of magnets on post-polio patients, magnets were found to reduce back pain by up to 75 percent. 8. MENTAL REFOCUSING. Often physical pain associated with the back is only part of the problem. Repressed emotions and stress, say some researchers, can trigger physical responses in the body. By focusing on the cause of your pain (i.e., daily stresses and problems, rather than the pain itself ), you can alleviate some of its symptoms.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=719) Modified Citrus Pectin (MCP) and Mercury Cleansing Programs...
Date:
June 21, 2005 05:02 PM
Modified Citrus Pectin (MCP) and Mercury Cleansing Programs by Isaac Eliaz, M.D., M.S., L.Ac. Modified Citrus Pectin (MCP) is a dietary supplement derived from the peel and pulp of citrus fruit. MCP is mostly known for its positive effects on cellular health. Recently, however, clinical research on MCP has produced exciting results for its use as a gentle chelator (eliminator) of mercury and other heavy metals. Some of the Expanding clinical applications for MCP include: The Problem with Mercury Recent news on mercury is particularly concerning for the U.S. population. In March 2004 the EPA issued a press release reporting nearly all fish contained traces of mercury. Some samples contained levels high enough to harm an unborn baby or young child's developing nervous system. These findings prompted the EPA to issue a warning to women who may become pregnant, pregnant women and nursing mothers advising them to eat only two meals of fish per week that are thought to have lower levels of mercury.1 In their most recent update (August 2004), the EPA issued a warning that 1/3 of the nation's lakes and 1/4 of its river ways are contaminated with toxic levels of mercury and other contaminants, and warned pregnant women and children against consumption of fish from these sources. Additionally, a National Academy of Sciences panel definitively warned that some children who had been exposed to mercury while in the wombs of their mothers were at risk for becoming those children "who have to struggle to keep up in school and who might require remedial classes of special education." The risk of mercury toxicity from fish has reached epidemic levels. Two studies have further spurred on the concerns of mercury toxicity, as they both found women to have mercury levels that are 8-10% above what is considered safe.1,2 Furthermore, women who ate more fish were found to have higher levels of mercury. Another source of mercury toxicity may be amalgam dental fillings. Heavy metals, in conjunction with the abundant presence of environmental toxins and xenoestrogens, constitute a dangerous insult to the body through DNA damage, hormonal modulation, immune suppression, oxidative stress, and cellular irritation. A New Application for MCP Use: Heavy Metal Detoxification The standard western medical approach for removing mercury from the body to treat mercury toxicity is chelation. This procedure is performed with harsh chelators that can cause multiple side effects while potentially robbing the body of some of its essential nutrients. While this may be the routine and most beneficial procedure when facing a serious toxicity problem, are there other, gentler ways to reduce mercury levels? Two recent clinical studies have found that MCP may be a promising new dietary solution for reducing heavy metal load. In one recent clinical study, MCP was administered to a group of volunteers, and baseline levels of their total body mercury burden were measured and then compared against levels after treatment with MCP (15 grams of PectaSol® daily) for four months. The results showed a significant average decrease (over 60%; p=0.03) in the total body mercury burden after treatment with MCP3 In an earlier study, PectaSol® was given to patients and proven to increase urinary secretion of heavy metals such as lead, mercury, cadmium and arsenic.4 Both studies concluded that MCP may be a promising alternative to the harsher intravenous chelating therapies as MCP was found to be both effective and free of any side effects. How MCP Works as a Gentle Chelator Pectins are natural gelling agents, binders, thickeners, and stabilizers in foods. They mostly consist of galacturonic acid and galacturonic-acid methyl esters with average molecular weights from 50,000 to 150,000 daltons. High-methoxy (HM) pectin has at least 50% DE (degree of esterification) or greater, while a low-methoxy (LM) pectin?s DE is 50% or less. For systemic chelation of heavy metals, pectin is modified to a low molecular weight, and low-methoxy content. My observation from using MCP as a detoxification agent in my clinic is that it works as a gentle chelator in the bloodstream and it is very useful for ongoing use. Because fish are still recommended as part of a healthy diet and an essential source of certain nutrients (essential fatty acids like DHA), mercury levels are also becoming a widespread health concern. It is a Catch-22 for dietary health. As the widespread environmental cleanup of mercury is unlikely in the short-term, the medical community should develop methods to treat toxicity or reduce high body levels of mercury body burden. One approach is the use of traditional and alternative medicine cleansing programs along with the use of dietary supplements such as MCP that may act as gentle chelators. For chelation purposes, 5-15 grams of MCP should be taken per day depending on mercury levels for one year. Maintenance at 2-5 grams per day thereafter is usually sufficient. In my practice, I use 15 grams per day or 15 grams per day in the first 3-5 days of the month and 5 grams per day for the remainder of the month. MCP is generally regarded as safe and is well tolerated. Reported side effects have been rare, but may include mild and transient gastrointestinal discomfort. References: 1-CDC Press Release: Blood and Hair Mercury Levels in Young Children and Women of Childbearing Age-United States, 1999 (see:/media/mmwrnews/n010302.htm#mmwr3) 2-Schober, SE, Sinks, TH, Jones, RL et al. (2003) Blood mercury levels in US children and women of childbearing age, 1999-2000. Journal of the American Medical Association. 289(13) :1667-74. 3-Eliaz, I. (2004) Modified citrus pectin (MCP) in the treatment of cancer. Paper presented at: The American Chemical Society Annual Meeting; Philadelphia, PA. 4-Eliaz, I. and D. Rode (2003). The effect of modified citrus pectin on the urinary excretion of toxic elements. Fifth Annual Conference of Environmental Health Scientists: Nutritional Toxicology and Metabolomics, University of California, Davis.
-------------------------------------------------------------------------------- Isaac Eliaz, M.D., M.S., L.Ac., is a pioneer in the field of integrative medicine and founder of Better Health Publishing®, an education-based company that provides health care professionals, consumers and other interested parties with scientific research on integrative medicine. He is a respected author, clinical practitioner and frequent guest lecturer on integrative medical approaches to health, immune enhancement and cancer prevention and treatment. Since 1991, Dr. Eliaz has maintained a busy private practice in Sebastopol, California, and is the current medical director of the Amitabha Medical Clinic and Healing Center (email:information@amitabhaclinic.com) which focuses primarily on integrative and holistic protocols for cancer patients as well as those with chronic health challenges.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=382) Move it and Lose it! Burn off body fat!
Date:
June 14, 2005 12:04 PM
Move it and Lose it! Burn off body fat! by Mimi Facher Energy Times, June 1, 1997 So you're feeling a little blah, a little overweight, and you're looking to drop a few of those winter pounds gained during the colder months. Maybe you've dabbled with diets and jogged around the neighborhood a few times but you're still packing unsightly bulges. If so, you may be considering the idea of turning to supplements to help you drop those pounds. Well, two types of diet supplements now generally available, combined with a diet and exercise program, may be able to help you trim those stubborn pounds. The first type of supplement, called metabolic optimizers, which include ephedra, caffeine and salicin (derived from willow bark), boost your metabolic rate, causing your body to burn calories faster. The second class, lipotropic substances, aid the body in fat mobilization, causing greater utilization of stored fat. These products include chromium, carnitine and hydroxycitric acid (HCA). Both classes of supplements have been around in various forms for quite a while but are now enjoying greater popularity among dieters. Trying to cope with a weight problem is a dilemma Expanding throughout modern society. According to a 1995 Harris poll, nearly 75% of Americans are overweight. Although it's well known that the way to lose weight is to expend more calories than you take in, supplements may be able to help you burn off extra calories. Thermogenesis and You Metabolic optimizers are supposed to aid weight loss through a process called thermogenesis. Thermogenesis is a natural process in which fat is burned to produce body heat. Fat that isn't burned is stored on the hips, thighs, stomach, etc. Thermogenic agents are designed to counteract your body's fat storage mechanisms by causing your body to maintain a higher metabolic rate-turning your internal thermostat up to burn fat faster. The thermogenic process can be jump-started by a number of factors including cold, exercise, certain dietary nutrients and metabolic optimizers. Ephedra The ephedra herb, also known as ma huang is one of nature's earliest medicines, known for over 5000 years to the Chinese, who used it to relieve allergies, coughing, wheezing and cold and flu symptoms. In the US, ephedra has been available since the 1800s. The ingredients in ephedra include the alkaloids ephedrine, pseudoephedrine and norephedrine. Concentrated forms of these substances are used in today's over-the-counter cold, allergy and asthma relief formulas. Ma huang's effectiveness as a weight loss aid is tied to its appetite suppressant and stimulant properties. By speeding up action of the thyroid gland, the ephedrine found in the herb acts a thermogenic agent, boosting the rate at which the body metabolizes fat and promoting weight loss. According to Mark Blumenthal, Executive Director of the American Botanical Council, "When used as part of a total package that includes diet modification and exercise, ma huang can be highly effective in the short run because it increases the speed of the body's metabolism and suppresses appetite." Because of their strong stimulant effect, ephedra and its derivatives have engendered some controversy. However, in its long history, billions of doses of ephedra have been consumed without problem. But ephedra supplements should only be used as directed on product labels. People with cardiovascular problems, diabetes, thyroid or prostate dysfunction, high blood pressure and those taking MAO inhibitors, pregnant or nursing should avoid this herb. Salicin Burns Fat Salicin, a substance derived from willow bark-which is also the original source for aspirin, a related compound-can boost the burning of fat when combined with ephedra. An animal study in the American Journal of Clinical Nutrition found that while ephedra boosted calorie burning by almost 10%, when ephedra was combined with aspirin, extra calorie burning just about doubled. Another study in the Internatioanl Journal of Obesity showed that when overweight women took aspirin and ephedrine during a meal, their bodies burned off more calories than normal. (Eating a meal produces a thermogenic effect as your body expends energy in digestion. That's why dieters are told not to skip meals. Skipping meals lowers your metabolic rate, decreasing your calorie expenditure.) Similar studies also show that caffeine, the stimulant that gives coffee its eye-opening kick, can also boost ephedra's thermogenic properties. But before using these combinations check with a health practitioner knowledgeable about nutrition. Aspirin or salicin may cause stomach upset in some people (although salicin is generally tolerated well.) Carnitine: Lipotropic Amino Acid To get carnitine into your system, you don't have to take it as a supplement. Your body already makes this vitamin-like substance. However, your body doesn't make that much. And it is said to be especially low in people with heart disease. This non-essential amino acid (said to be non-essential because human bodies produce it) is a key ingredient in the formation of mitochondria membranes. Mitochondria are tiny structures in your cells that burn fats for energy. Consequently, sufficient carnitine is necessary for the movement of fat into the mitochondria where it is consumed. When not enough carnitine is present, the breakdown of long chain fatty acids slows down. Said to improve the recovery rate for athletes (it may limit the production of lactic acid, a waste product in muscle tissue), carnitine can also lower cholesterol levels, boost levels of HDL (the good cholesterol) and decrease serum triglycerides (blood fats linked to heart disease). Not bad for a nutrient that coaxes fat into those teeny, ceullular, mitochondrial furnaces. Go for the Chrome Chromium-based supplements work as lipotropic agents by aiding insulin use in the body. This essential trace mineral is required for normal protein, fat, and carbohydrate metabolism. According to Dr. Michael Janson, author of The Vitamin Revolution in Healthcare and President of the American Preventive Medical Association (APMA), "Chromium is important for proper insulin activity. Insulin moves sugar into the muscle cells, where it is burned off as energy. Chromium improves the activity of insulin, and since insulin causes fat deposition, less of it means less fat deposition." Chromium has also been shown to build muscle tissue and to reduce LDL cholesterol, which has been linked to heart disease. Although the body's minimum requirement is low, the American diet tends to be deficient in chromium, in part because the mineral can be difficult for the body to absorb. The fact that, in nature, chromium is most powerfully concentrated in brewer's yeast, wheat germ and liver-items most Americans rarely eat-probably hasn't helped either. Other natural sources of chromium include whole grains, molasses and beef. But it is estimated that 50% of Americans are chromium deficient. An early study found that overweight adults taking a chromium supplement lost an average of 22% body fat, while maintaining or gaining lean body mass. In another study, athletes consuming 200 mcg. of chromium a day showed an average loss of 7.5 lbs. of body fat after six weeks, without a corresponding loss of muscle tisue. Overall, although some studies question chromium's precise effects, many experts are optimistic about this substance because of its relationship to insulin in the body's metabolism. Hydroxycitric Acid (HCA) Another possible addition to the dieter's arsenal is HCA. In nature, HCA appears chiefly in a fruit called garcinia cambogia (sometimes also called Malabar tamarind or brindall berry), a citrus plant found primarily in Asia, where the rind is often used as a flavoring agent. HCA works by inhibiting the enzyme in the body responsible for converting carbohydrates into fat. HCA causes calories to be burned in an energy cycle similar to thermogenesis and acts as somewhat of an appetite suppressant. HCA is also said to have a role in reducing triglycerides and LDL cholesterol levels. Several animal studies have shown that HCA caused significant weight loss without a reduction in lean body mass. In other words, the pounds that came off came out of fat stores, and not out of energy or muscle reserves. This means that HCA takes off not just weight but body fat, making it a potentially effective tool against weight regain. Dr. Elson Haas, director of the Preventive Medical Center of Marin in San Rafael, CA, and author of Staying Healthy With Nutrition: The Complete Guide to Diet and Nutritional Medicine, believes that HCA can be a helpful aid for dieters when used in combination with eating habit changes and exercise. He recommends an HCA and chromium blend for optimum appetite suppression. "This combination can keep the appetite down and reduce sugar cravings," he says. Although human research data on HCA is still in the preliminary stages, the animal study results are positive, and the supplement seems to have minimal side effects in most people. Some Overall Recommendations You are likely to lose weight faster if you eat sensibly. This means avoiding foods high in fat or sugar (which are the most likely to add to stored body fat), but it doesn't mean starving yourself. A sensible balanced diet, along with moderate exercise, is still the best prescription for weight loss. As Dr. Haas puts it, "I'm a firm believer in diet and exercise. Using supplements responsibly can help you to lose weight provided they're combined with dietary changes and exercise. They won't work if you don't change anything." No one is suggesting that dietary supplements are a miracle cure for being overweight-as always in self-health care, there are no magic wands. But, used as directed and combined with a good diet and exercise plan, you could find that these supplements might help you work your way to a slimmer you. Mimi Facher is a freelance writer who has contributed to Prevention, Cosmopolitan and Self.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=349) Your Healthy Harvest
Date:
June 14, 2005 11:05 AM
Your Healthy Harvest by Marjorie Flakowitz Energy Times, August 15, 2004 Once frowned on by conventional farmers, organic food has won respect from everyone concerned about the health of both the earth and the people who inhabit it. Today, organic farming is considered one of the most rapidly growing areas of American agriculture. Organic foods sales topped $9 billion in 2002 and grew about 20%, up to almost $11 billion in 2003 (Organic Trade Association). So when you buy organic, you join an Expanding market that takes advantage of great-tasting, good-for-you food. Long ago, when the practice of farming was first devised, all farming was organic farming. So today's organic movement is bringing farming back to its roots. But, safe to say, that is not what's motivating most consumers. A main reason for the popularity of organic food derives from the reassurance that organic foods, raised without artificial chemicals and pesticides, cut your exposure to toxic residues. A growing body of research shows organic food is richer in beneficial natural substances, too. " Organic food and organic farming represent a philosophy that goes beyond just the quality of the food," says Steve Meyerowitz in The Organic Food Guide (Globe Pequot). "It strives to maintain the integrity of the entire food chain-plants, soil, air, water, animals and people. We are all part of the same ecosystem." By eating organic, you eliminate pollution both from your body and the earth. Because our bodies are made of the animal and plant products we consume, our internal, physiological ecosystem and the earth's environment are inexorably entwined. Chilling Arctic Evidence As evidence of this connection, consider what's happened in the Arctic. Researchers who have analyzed Arctic water, ice, snow, soil and plants have found that chemicals used in farming and industry in other parts of the world have traveled north and accumulated in alarming quantity. How and if these chemicals break down depends on sunlight and the amount of organic matter contained in Arctic waters (American Chemical Society, 9/11/03). " Once pollutants enter the water column, their behavior is poorly understood-particularly the processes that govern their lifetime and concentrations," says Amanda Grannas, PhD, a researcher at Ohio State University. "Such pollutants are now being found in wildlife, from fish to seals to whales, and even in people living in the Arctic." Dr. Grannas and others looked at the pesticides lindane and hexachlorobenzene (HCB), two chemicals that have migrated to Arctic waters. Lindane is used by American farmers to treat seeds before they are planted. HCB, banned in the US in 1984, is still used in other countries to protect wheat from fungus. The scientists found that sunlight at the top of Arctic waterways can help break down some pesticides. At lower depths, however, cut off from the sun's rays, pesticides can remain largely intact. In this research, lindane proved to persist much more readily than HCB. " Lindane is one of the most persistent of pollutants," warns Dr. Grannas. "This could be because it's photochemically inert, whereas pollutants like HCB degrade relatively quickly. The main message is that pollutants can behave quite differently. These pollutants already affect local ecosystems, and could have repercussions for human health." Organics Means More Benefits Researchers are also finding that organic produce contains larger quantities of beneficial natural chemicals. For instance, one study (Journal of Agriculture and Food Chemistry 2/26/03) showed that berries and corn grown organically can have almost 60% more polyphenolics. Polyphenolics are antioxidants plants use for protection against disease and which are good for humans. Researchers believe that when crops are grown conventionally, protected by pesticides and herbicides, they produce fewer of these substances. " This really opens the door to more research in this area," says Alyson Mitchell, PhD, assistant professor of food science at University of California at Davis, who led the research. These scientists compared levels of total polyphenolics and vitamin C content in marionberries (a type of blackberry) and corn grown organically, sustainably or conventionally, and also looked at chemicals in strawberries grown either sustainably or conventionally. (Sustainable farming falls between the organic and conventional methods, and concentrates on farming that's self-sufficient-for example, feeding cows hay you've grown yourself, and then using the cows' manure to fertilize another crop.) They found that organic marionberries and corn had 50% to 58% more polyphenolics. The sustainably grown strawberries had 19% more polyphenolics. And all the organic produce contained more vitamin C. Self-Defense for Plants According to Dr. Mitchell, the organic crops contained the high levels of polyphenolics you'd expect to find in wild plants, suggesting that, on conventional farms, pesticides reduce the necessity for plants to make these protective, natural chemicals. " If an aphid is nibbling on a leaf, the plant produces phenolics to defend itself," she says. "[P]henolics guard the plant against these pests." Pesticides kill insects like aphids and thereby reduce the antioxidants produced by the plant. " This helps explain why the level of antioxidants is so much higher in organically grown food," Mitchell says. "By synthetically protecting the produce from these pests, we decrease their need to produce antioxidants. It suggests that maybe we are doing something to our food inadvertently. " We know [polyphenolics] are beneficial [to human health], but we don't know what types of polyphenolics are beneficial, or in what quantities," Dr. Mitchell notes. " Originally, the question was just really intriguing to me. I found that the higher level of antioxidants is enough to have a significant impact on health and nutrition, and it's definitely changed the way I think about my food." Vitamin C in Oranges Meanwhile, nutritional research on the vitamin C in oranges turns up similar results: organic oranges are richer in this antioxidant nutrient than conventionally grown oranges (Great Lakes Regional Meeting, American Chemical Society, 6/2/02). The more common supermarket oranges are significantly larger than organically grown oranges, and they have a deeper orange color. Because of their larger size, "we were expecting twice as much vitamin C in the conventional oranges," says Theo Clark, PhD, chemistry professor at Truman State University in Kirksville, Missouri. But when he isolated the chemicals in the oranges and further refined his search with nuclear magnetic resonance (NMR), spectroscopy demonstrated that organically grown oranges possess 30% more vitamin C than the conventionally grown fruits-even though they are only about half as large. Dr. Clark isn't sure why organic oranges are richer in vitamin C, but he says, "...[W]e speculate that with conventional oranges, [farmers] use nitrogen fertilizers that cause an uptake of more water, so it sort of dilutes the orange. You get a great big orange but it is full of water and does not have as much nutritional value. " However, we can only speculate. Other factors such as maturity, climate, processing factors, packaging and storage conditions require consideration." Along with analyzing oranges, Dr. Clark and his research team questioned about 70 people to measure their concept of the nutritional value of organic oranges. In this survey, 85% of the respondents thought that organic oranges have a higher nutritional content than conventionally grown fruit. Dr. Clark's laboratory work shows that "they were right on." In Dr. Clark's view, these issues are important because consumers have a right to know the real nutritional content of organic produce, and the fact that analyses show that organic fruit has much more vitamin C validates the benefits of eating organic. Defense Mechanism Both plants and animals protect themselves from disease with many of the same chemicals. The natural substances that, in a farmer's field, defend vegetables from insects and microbes before they are harvested for your dinner go to work defending your body after you eat and digest them. When you eat organic you bolster your health with more of these natural wonders. No wonder organic is becoming so popular!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=343) Power Meals - Shakes, smoothies and bars help make getting good nutrition easy.
Date:
June 14, 2005 08:28 AM
Power Meals by Phyllis D. Light, RH Energy Times, March 12, 2004 Choices, choices, choices: For convenience, nutrition and either low-calorie or low-carb dieting, you now have an enviable range of choices. Shakes, smoothies and bars help make getting good nutrition easy. Whatever your inclination, drinks and bars offer a shortcut to daily nutrition without cooking. And whether you use them as meal replacements, diet aids or healthy snacks, these power meals fill you up without filling you out. That's the main reason these items have grown in popularity in natural food stores among the nutritionally knowledgeable searching for healthier alternatives to fast food. No matter how hectic your day, you have no excuses anymore for missing your daily required antioxidants and minerals. Either select a bar suited to your taste, or put your blender or food processor to work in creating drinks that use fresh fruits and veggies, yogurt, low-fat milk or ice and protein powders for maximum nutritional output. Quality note: always be sure to use organic foods for the best nutritional content, flavor and taste. Powerful Nutrition Prepared protein shake mixes and bars are ideal for losing weight, Expanding personal energy or building muscle. Protein mixes are available in an assortment of flavors that are generally high in amino acids (protein building blocks) and low in carbohydrates. Of course if you are on a low-carb diet, forsake putting fruits and vegetables in your shakes; these items are too high in carbohydrates. What's more, bars not only provide a wealth of different tastes, but different bars are also tailored to different needs-whether you're seeking to lose weight, gain muscle or replace a meal, there's a bar out there just for you. If you use power shakes as meal replacements and you are on a low-carbohydrate diet, make sure the drink supplies plenty of protein and few carbohydrates. If you use either shakes or bars to replace one or more meals during the day, take a fiber supplement in addition. Fiber, which contains no calories, helps speed food through your digestive tract and may lower your risk of heart disease and cancer (Lancet 5/2/03). And remember: powders and bars should also be low in sugars and saturated fats. The weight-loss benefit: If you drink high-protein shakes or eat bars that taste good and leave you feeling satisfied, you'll have a better chance of sticking to your diet long enough to lose a significant amount of weight. Drink to Lose Research into weight loss has established protein shakes and bars as reliable diet aids. A study of 100 dieters between the age of 35 and 65 found that people who drank a daily soy protein shake lost more than 14 pounds each in three months (Eur J Clin Nutr 2003; 57:514). And in a study reported in the Journal of American Dietetic Association (3/01), folks who had a protein shake in place of one daily meal lost almost twice as much weight over 12 weeks than those who ate their regular food with the same amount of calories. Drinking your breakfast in the form of a protein shake can both increase your metabolism and help curb your appetite for the rest of the day. Researchers at Harvard University found that metabolism rose faster after eating a high-protein breakfast and that blood-sugar levels stayed high for about six hours after the meal (AHA Annual Conference on Cardiovascular Disease Epidemiology and and Prevention, 3/6/03). In comparison, when a sugary breakfast is consumed, blood-sugar levels rise quickly but fall rapidly, causing fatigue, tiredness and sleepiness. Protein shakes are especially effective when you are on a weight-loss plateau, trying to lose those last few tenacious pounds. (But shakes, smoothies and bars should not be your only meals of the day. Eat at least one low-calorie meal daily to supply nutrients that may not be in your shakes or bars.) Smoothie Operator Made with fruits and vegetables, smoothies are a tasty way of getting extra amounts of nutrients and soluble fiber. Using low-fat milk, yogurt, buttermilk or kefir, plus ice, creates a tempting and wholesome blend that lights up the taste buds. Powdered mixes can be used for added protein. Fruits and vegetables in your smoothies not only fill you up on relatively few calories, but they boost your energy and supply plenty of bioflavonoids (healthy, natural chemicals from plants), antioxidants, vitamins and minerals. The fiber in smoothies can help reduce cholesterol, relieve constipation and aid in the prevention of high blood pressure. For reduced calories and added heart health benefits, low-fat or no-fat milk products can be used in place of cream or regular milk in most recipes. For the best taste sensation, combine sour and sweet fruits together. Adding raw fruits and vegetables to smoothies provides natural enzymes that help with digestion and act as catalysts in hundreds of chemical reactions throughout the body. (You can also take enzymes in supplemental form.) Enzymes are not present in cooked foods since the heat of cooking destroys them. Nutrition for Kids If you have trouble getting your children to eat their fruits and vegetables, try giving them smoothies. Children can't resist these naturally sweet and healthy creations. According to Sally Fallon, author of Nourishing Traditions (New Trends Publishing), smoothies should be "high in quality, contain healthy fats, be naturally sweet, and contain fresh seasonal fruits and vegetables." Fallon also believes children should consume what are called lacto-fermented foods, including yogurt and kefir, which are aged to contain the kinds of friendly bacteria that normally live within our digestive tracts. For kids, Fallon also encourages the use of cream or cultured milk to ensure adequate fat and calcium, so important for the development of growing bodies. Smoothies are an interactive drink as far as children are concerned, since they love to help blend them. For extra nutrition power, add nutritional yeast, nut butters or ground flaxseeds. These supply additional vitamins and minerals, along with healthy fats. You can also add silken tofu to bump up the protein content. If your child is lactose intolerant, try mixing smoothies with rice milk, soy milk or juice. Bars Designed With A Woman's Needs in Mind The modern woman is a multitasking wonder, constantly juggling work and home responsibilities. So it's no wonder that bars aimed at women are among the most popular bars there are. Many women, in eyeing the bathroom scale, shortchange themselves of the nutrients they need. That's why a woman's bar needs to provide minerals like calcium, a bone-building necessity. Women also need to ensure that a bar contains enough of the B vitamins, particularly folate. This is especially true if a woman is pregnant, or wants to be: Folate is crucial in helping to prevent neural tube birth defects. Folate also teams up with two other B vitamins, B6 and B12, to control homocysteine. This protein metabolism byproduct, when present in excessive amounts, is associated with heart disease. Another popular ingredient in women's bars is soy, which has been duly recognized for its heart benefits. Studies also indicate that soy may help keep bones strong. (Not to mention the fact that the moisture soy holds helps make a bar's texture that much more appealing!) The Protein Game If you are unsure about how much protein you need each day, you are not alone. Are you getting too much, not enough, or just enough? Most people need between 45 and 60 grams of protein daily, and most protein shakes contain about 14 and 20 grams of protein per serving (check your labels). No matter what your nutritional needs are, you may find an answer in a smoothie, shake or bar. When it comes to power nutrition, tasting is believing!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=338) Better Bones 
Date:
June 11, 2005 05:24 PM
Better Bones by Deborah Daniels Energy Times, March 13, 2004 As America ages, osteoporosis, a weakening of the bones, grows into an ever-Expanding problem. Currently, it affects more than 44 million Americans. Women are in special danger; of those who suffer weak bones, about 35 million are women. This problem causes a huge amount of damage-physical, emotional and financial. The national bill for hospital and nursing care for osteoporosis victims tops $17 billion a year, about $47 million a day. Odds are, your bones need help. According to the National Institutes of Health, the bones of more than half of all Americans over age 50 are weak enough to put them at risk of osteoporosis. Weak bones linked to osteoporosis continue to present a serious risk to health. A study published in the British Medical Journal shows that fractures in older people are just as life-threatening today as they were two decades ago (2003; 327:771-5). When researchers looked at broken legs among more than 30,000 people over the age of 65, they found that just as many people die today after these kinds of bone breaks as they did during the 1980s. Their findings emphasize how important strong bones are to survival. This study showed that breaking your leg at age 65 or older increases your risk of death more than 12 times. And these high death rates, according to the researchers, reinforce the fact that preventing osteoporosis saves lives. Blowing Smoke Through Bones While many bone experts blame the high rate of osteoporosis on sedentary lifestyles and foods low in calcium, Australian research has turned up another bone-weakening villain: smoking. According to these scientists, smoking may be the most destructive lifestyle habit that destroys bone in older women. While other studies have pointed to smoking as a factor in bone loss, this most recent study purports to show that smoking may be one of the most important influences on weak bones (J Bone Min Res 9/03). " This will be an important step forward in the management of osteoporosis, since the results of this study can be used to improve current approaches to preventing bone loss," says researcher John Wark, PhD. Dr. Wark's study found that older smokers are particularly prone to weak bones. While smoking is always bad for bone strength, after menopause tobacco smoke seems to exert an even deadlier affect on your skeletal support. " [T]he damaging effects of cigarette smoking may well have been underestimated in the past," says Dr. Wark. When you inhale cigarette smoke, your lungs are exposed to about 500 harmful gases, including carbon monoxide, carbon dioxide, benzene, hydrogen cyanide and ammonia. The infusion of these gases cuts back on the available oxygen used for building bone and other tissues. Along with these gases, small particles containing chemicals like anatabine, anabase, nicotine, monicotine and other carcinogens also filter into the lungs. Studies (Acad Ortho Surg 2001; 9:9) indicate that bathing the body in these chemicals results in: Bone Building While it's never too late to build more bone, the best time for laying down a dependable musculoskeletal foundation is before age 30. That way, as you get older, your strong bones can better resist the weakening effects of aging. Ipriflavone is a natural chemical that has been found to help protect bone. Researchers believe that this supplement can help bones strengthen by absorbing more calcium (Calc Tissue Int 2000; 67:225) Other ways to make bones stronger include: Weak bones can put a severe crimp in your lifestyle and put your life at risk. How can you tell what shape your bones are in? Health practitioners can help you get the appropriate bone density test. But the tone of your muscles are also a good indicator: Exercise to tone those muscles and chances are you're building your bones, too. All you have to do is get moving!
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Coral Calcium is a salt of calcium inferred from fossilized coral reefs. Coral Calcium is discovered commonly installed in the dirt in Japan. Coral calcium is made principally out of the shells and skeletons of reef-building coral and tiny ocean life, for example, star sand that occupy the zone. 
CLA, or conjugated linoleic harsh corrosive, has been the subject of an assortment of exploration in the previous numerous years. Over 200 studies have indicated that it may assume an exceptionally vital part in weight reduction, as well as in serving to battle disease, diabetes, and atherosclerosis (solidifying of the corridors). It is not made in the human figure, and is discovered commonly in meat and dairy fats, or as an over-the-counter supplement. Artificially, it is a marginally changed type of the fundamental greasy harsh corrosive, linoleic harsh corrosive, and an omega-6 fattening harsh corrosive. The CLA discovered regularly in the sustenance sources is most astounding in dairy cattle and bovines that expend an eating methodology rich in grasses, and the individuals who are nibbling in pastures; instead of the aforementioned bolstered monitored food, for example, grain, feed or silage. To quote Larry Satter, an Agricultural Research Dairy Scientist, "Pasture-nibbled cows had 500% more CLA in their milk than those nourished silage." Since the fat is the particular bearer of the CLA, the substance of the fat in the milk is extremely paramount. The higher the fat substance, the more stupendous the CLA sum is in the milk. This is as opposed to what is proposed when drinking milk. Skim or 1% is constantly proposed over the entire or 2%, to maintain a strategic distance from the overabundance calories and fat, since normally drain was tanked for the calcium content (or the protein). This adds an entire new profit to drain and dairy items, clearing a path for science to control the CLA substance of milkfat, and may open the entryway the CLA-improved sustenances. 
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