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  Messages 1-39 from 39 matching the search criteria.
The Importance of Vitamin D-3 Darrell Miller 9/28/22
Developments in the Legal Cannabis Industry Darrell Miller 3/3/17
Seasonal Flu Reaches Epidemic Levels in US Darrell Miller 2/6/17
Why is it Important that Your Probiotics are Enteric Coated? Darrell Miller 9/28/16
Inflammation Pain Got You Down? EPA Fish Oil Can Help Darrell Miller 10/12/15
Facts about Astaxanthin Darrell Miller 10/22/13
Why Is Alpha Lipoic Acid The Best Antioxidant Supplement? Darrell Miller 1/15/13
How Does D-Mannose Help With Bladder Infection? Darrell Miller 2/28/12
What Liver Blend Does For You Darrell Miller 11/26/11
Fight Pain Improve Blood Sugar And Heart Health with OPC Pine Bark Extract Darrell Miller 6/7/11
How Does Glutathione Work in the Body to Detox Darrell Miller 5/6/11
How to detoxify from heavy metal aluminum toxitity Darrell Miller 11/9/10
Cascara sagrada and constipation Darrell Miller 11/9/10
Black Walnut Darrell Miller 6/5/09
Hoodia Gordonii Darrell Miller 12/10/08
Guar Gum Fiber Darrell Miller 10/27/08
Acidophilus Darrell Miller 8/23/08
Garcinia Cambogia Darrell Miller 7/8/08
Licorice Root Darrell Miller 5/23/08
GTF Chromium Darrell Miller 4/23/08
What is Hoodia? Darrell Miller 4/8/08
Eighty Seven Percent of All Type 2 Diabetes Can Be Prevented Naturally Darrell Miller 1/24/08
The Healing Power Of Borage Oil’s GLA Darrell Miller 11/13/07
Omega-3 Relieves Depression in Some Individuals Darrell Miller 11/2/07
Artemisinin For Better Health And Wellness Darrell Miller 10/25/07
Reduce Your Cholesterol With Natural Vitamins Darrell Miller 7/12/07
Do you experience muscle pain and inflammation? Darrell Miller 4/25/07
Learn about Bone Health! Darrell Miller 4/20/07
Lower Cholesterol Naturally! Darrell Miller 10/6/06
Vitaberry Plus + Super Fruit Antioxidant Darrell Miller 12/7/05
GPC (GlyceroPhosphoCholine) Versatile Life Support Nutrient .... Darrell Miller 6/21/05
Gotta Habit Darrell Miller 6/14/05
Don't Be Blue - Does winter got you singing the blues? Darrell Miller 6/13/05
Down with Blood Pressure Darrell Miller 6/12/05
Summer Sports Nutrition Guide Darrell Miller 6/11/05
What is Hoodia? Darrell Miller 6/9/05
AMINO ACIDS AND PROTEIN Darrell Miller 6/9/05
Heart Science - A Five-Tiered Approach to Heart Health ... Darrell Miller 6/2/05
Re: Keeping the Intestines Healthy Darrell Miller 5/12/05




The Importance of Vitamin D-3
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Date: September 28, 2022 01:10 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Importance of Vitamin D-3

Vitamin D is a vital nutrient that helps the body absorb calcium and phosphorus, two minerals essential for strong bones and teeth. Vitamin D also supports the health of the immune system, heart, and lungs. Despite its many benefits, vitamin D is not found in many foods. As a result, many people rely on supplements to ensure they are getting enough vitamin D.

There are two ways to get vitamin D: through food and supplements, or through exposure to sunlight. Foods that contain vitamin D include fatty fish such as salmon, tuna, and mackerel; beef liver; cheese; egg yolks; and fortified foods such as milk, orange juice, and cereals. You can also get vitamin D through supplements. Supplements come in two forms: vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol).

Vitamin D from Sunlight

The body can also produce vitamin D from exposure to sunlight. Ultraviolet B (UVB) rays from the sun trigger vitamin D synthesis in the skin. However, exposure to UVB rays is limited by the use of sunscreen, clothing, glass windows, and time spent indoors. In addition, UVB rays do not penetrate clouds, so weather can also affect vitamin D production. The latitude of a location also affects the amount of UVB radiation that Reaches the earth's surface—the closer a person lives to the equator, the more UVB radiation is available. For example, people living in Boston (latitude 42°N) have access to about one-half the amount of UVB radiation that is available to people living in Miami (latitude 25°N). As a result, people who live in northern locations are at greater risk for vitamin D deficiency because they have less access to UVB radiation year-round.

Vitamin D Deficiency

Although sunshine is the best source of vitamin D, many people do not get enough sunlight exposure to generate sufficient amounts of this important nutrient. In addition, older adults cannot convert as much 7-dehydrocholesterol to vitamin D3 as younger adults because their skin contains less 7-dehydrocholesterol and their kidneys are less efficient at converting 25(OH)D to 1,25(OH)2D. As a result, older adults are at increased risk for vitamin D deficiency. African Americans are also at increased risk because melanin reduces skin penetration by UVB radiation. People with darkly pigmented skin may need up to 10 times more sun exposure than people with lightly pigmented skin to generate an equivalent amount of vitamin D3.

In Summary:

Vitamin D is an important nutrient that helps support bone health and immunity. While most people get some amount of vitamin D from exposure to sunlight, many do not get enough. This can put them at risk for deficiency, which can lead to health problems such as osteoporosis and Rickets. Luckily, there are many ways to increase your intake of vitamin D through diet and supplementation so you can experience all the benefits this nutrient has to offer!

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Developments in the Legal Cannabis Industry
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Date: March 03, 2017 10:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Developments in the Legal Cannabis Industry





The legal marijuana industry is currently the fastest-growing business in the United States. If it continues to expand and Reaches all 50 states, it could become even bigger than the organic foods market. According to The ArcView Group, a research company focused on cannabis industry investment, the U.S. market grew 74% in 2014, up from the prior year of $1.5 billion.

Key Takeaways:

  • states that have legalized cannabis are benefiting from taxes.
  • Colorado is expected to generate $135 million in cannabis taxes and licenses fees in fiscal year 2015-16
  • the Cannabidiol (CBD) market will grow to a $2.1 billion market in consumer sales by 2020 with $450 million of those sales coming from hemp-based sources.

"A report published by The Hemp Business Journal estimates that the Cannabidiol (CBD) market will grow to a $2.1 billion market in consumer sales by 2020 with $450 million of those sales coming from hemp-based sources. In 2015, the market for consumer sales of hemp-derived CBD products was $90 million, plus another $112 million in marijuana-derived CBD products which were sold through dispensaries - bringing a total CBD market to $202 million last year"



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.prnewswire.com/news-releases/developments-in-the-legal-cannabis-industry-614706044.html&ct=ga&cd=CAIyGjViYjkzZDJlODZhNjI0ZWE6Y29tOmVuOlVT&usg=AFQjCNF1jG0FcTxCJrY6tW_jWu1BLTmmNA

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Seasonal Flu Reaches Epidemic Levels in US
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Date: February 06, 2017 05:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Seasonal Flu Reaches Epidemic Levels in US





When you think about a horrible disease you may not think about the flu, but it's turning into an epidemic. This may have something to do with a lower number of flu shots being handed out. The CDC is looking into the way this may affect society, the flu could be very bad this year.

Seasonal Flu Reaches Epidemic Levels in US

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Why is it Important that Your Probiotics are Enteric Coated?
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Date: September 28, 2016 05:41 PM
Author: Darrell Miller
Subject: Why is it Important that Your Probiotics are Enteric Coated?

By definition, the term probiotic refers to live bacteria that are used for the purpose of boosting the health of a person. Even though most people think of bacteria as pathogenic organisms, the fact is that the body is made up of both beneficial and destructive bacteria. Probiotics are therefore classified as useful bacteria since their activities are beneficial to the body. This article discusses the rationale behind the enteric coating of these substances.

There is one main reasons as to why probiotics should be enteric coated. The first rationale is the fact that the coating technique facilitates the survival of the bacteria until it Reaches the desired destination. In the process of being ingested, the probiotics are generally exposed to destructive conditions while it passes through the first stage of digestion.

 For instance, the acidic conditions prevailing in the stomach are very harsh to the bacteria and can result to their instant destruction. The coating is therefore used as a means of increasing the chances of survival for these products.

To ensure that the probiotics you consume make it to the intestinal tract where they can thrive and improve health. make sure your probiotic is enteric coated.



References

//www.ncbi.nlm.nih.gov/pubmed/24914724

//www.webmd.com/digestive-disorders/features/what-are-probiotics

https://www.consumerlab.com/answers/Do+probiotics+have+to+be+enterically+coated+to+be+effective%3F/probiotics_enteric_coating/

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Inflammation Pain Got You Down? EPA Fish Oil Can Help
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Date: October 12, 2015 12:55 AM
Author: Darrell Miller
Subject: Inflammation Pain Got You Down? EPA Fish Oil Can Help

There's absolutely no doubt as to whether fish oil contains anti-inflammatory benefits. The main question is how one can tap into these benefits. How fish oil helps in inflammation pain is well understood. Basically, fish oil contains EPA and DHA which are Omega 3 fatty acids. Our body cannot make these essential fats on its own, and it's therefore important to have them in included in the diet just like other minerals and vitamins.


Effects of Inflammation Pain
There are many case studies that have been published to demonstrate the anti-inflammatory activity of EPA-rich fish oil. Inflammation is generally a response that our body uses to respond to any tissue injury or infections. These inflammatory processes have recently been understood as the underlying causes of many diseases of the modern world including obesity, diabetes, cardiovascular disease, osteoarthritis, Alzheimer's disease, degenerative disc disease and many more.

Fish oil has shown to have potential benefits to all these diseases, but the main question is how one substance could help so many different conditions. However, fish oil contains essential omega 3 fats that benefit a wide variety of health conditions, either related or caused by inflammation.


How EPA helps inflammation

EPA (Eicosapentaenoic acid) is an omega 3 fatty acid present in fish oil and is used by the body as a building block for manufacturing a group of chemicals with anti-inflammatory effects. This simply means that EPA acts as the fuel for the ability of our body to make its own anti-inflammatory chemicals. Scientists and nutritionists have shown that our modern diet is deficient in these omega 3 fatty acids. They also suggest that this may serve as an explanation of the current epidemic of inflammatory pain related illnesses that are being experienced in most western countries.


EPA fish oil dosage

In order to achieve significant anti-inflammatory effects, you must take a large daily dose of EPA-rich fish oils. One study has shown that patients suffering from disabling pain are able to achieve a significant pain relief that could not be helped by prescriptive pain medications, after taking high doses of fish oil for a prolonged period of time. In this study, all the patients had suffered severe disabling pain that could not be relieved through prescriptive pain medications. The pain was caused by something different in each of the cases.

One of the patients had second and third-degree burns over large parts of his body and was still experiencing pain despite taking morphine. Another patient had suffered a disc herniation in his neck. In all these cases, patients experienced significant relief after taking high doses of EPA fish oils and were able to return to their normal daily living. The fish oil daily dosage included 3200 mg to 7000 mg of EPA and DHA combined.


Assessing your need for omega 3

The expected results from taking fish oil largely depend on your current intake of omega 3 fats. If your body is currently depleted on omega 3 fats, it will certainly take much longer before it Reaches the optimal levels of omega 3 and to achieve the full benefits of EPA. To determine your current omega 3 status, a simple blood test can measure your Omega-Index.

 

 

Resources:

//www.webmd.com/diet/what-to-know-about-omega-3s-and-fish
//fishoildeal.com/what-is-fish-oil-good-for/fish-oil-anti-inflammatory/
//www.ncbi.nlm.nih.gov/pubmed/20500789


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Facts about Astaxanthin
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Date: October 22, 2013 10:47 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Facts about Astaxanthin

Astaxanthin

 Astaxanthin is said to be a carotenoid which belongs to larger class of phytochemicals which is known as terpenes. It is built up of five carbon precursors. It is a metabolite of canthaxanthin and zeazanthin which contains both ketone and hydroxyl fuctional groups. Astaxanthin is a lipid-soluble pigment and is colorful. The color of it is due to the extended chain of conjugated double bonds which is also responsible for the astaxanthin’s antioxidant function. It is found in feathers of some birds, yeast, trout, shrimp, crustaceans, crayfish, krill, salmon and micro algae. The red color of cooked shellfish and red color of salmon is due to the presence of astaxanthin.

How Astaxanthin Helps the Eyes?

When astaxanthin is combined with omega-3 fatty acids and Vitamin E then it helps the eyes to recover the watery condition and it lubricates it too. It helps the eyes to absorb Vitamin E by which it then nurtures and feeds the choroid and optical nerve which is behind the retina. This is the place where the blood vessel enters in to and leaves and this is the place where communication between retina and brain are established. The macula is protected by astaxanthin by its antioxidant activity and it also helps in eliminating the free radicals. It helps in reducing the risk of cataracts and AMD. It also helps in preventing the eyestrain and it also decreases its effects. The inflammation in the muscles of the eyes is decreased by it and it also improves the blood flow of the eyes.

Health Benefits of Astaxanthin

It is considered as a strongest natural antioxidant which crosses the brain-blood barrier and protects the nervous system and brain, works in every part of skin, organs and body, crosses the retinal-blood barrier and thus protect the eyes and it Reaches inside and out of every part of the cell. It also helps in repairing the injured tissue.


References: 

  1. //en.wikipedia.org/wiki/Astaxanthin
  2. //ezinearticles.com/?Eye-Vitamins---Your-Eyes-Looking-Far-and-Near&id=3800566
  3. //ezinearticles.com/?The-Benefits-of-Astaxanthin---Natures-Strongest-Antioxidant&id=4721603

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Why Is Alpha Lipoic Acid The Best Antioxidant Supplement?
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Date: January 15, 2013 02:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Why Is Alpha Lipoic Acid The Best Antioxidant Supplement?

Thiocitic acid, also called alpha lipoic acid, is a natural antioxidant found in the body cells. It has been used by several people since 1950s for various purposes. It's a fatty acid that prevents oxidative destruction precipitated by free radicals and also aids in the breakdown of glucose to release energy. The health benefits of alpha lipoic acid supplements are so many. Individuals suffering from diabetic neuropathy, premature skin aging and glaucoma can greatly benefit from the use of the antioxidant.

Water And Fat Soluble Antioxidant:

Thiocitic acid is soluble both in water and fats, therefore it Reaches many parts of the cell to guard against free radical destruction. It's a potent antioxidant. Currently, these fatty acids are taken by many people in supplement forms. If you intend to use the antioxidant supplement, the following are some of the benefits of thiocitic acid.

This antioxidant is produced in the body and it can also be included in the diet; its use in the form of supplements is on the rise. When it is eaten in the form of supplement, it's converted into a very active form known as dihydrolipoic acid. It is also vital in the production of other antioxidants like vitamin C, vitamin E, and glutathione.

Liver Health:

Both thioctic acid and glutathione assist in liver detoxification. It attaches to the toxins in the body and assist in their elimination from the bloodstream. It's also vital in promoting good health of the liver. Alpha lipoic acid is also critical on the skin. It aids in cell regeneration and guards the skin against free radicals that precipitate aging of the skin. It assists in making the skin look younger and radiant. It may also help in decreasing wrinkles and fine lines. It is one of the most effective anti-aging supplements. It is sometimes called universal supplement. Benefits of thiocitic acid are not limited to skin, it's also vital in the treatment of conditions like neuropathy. Since it assists in changing glucose into energy, it can be important in losing weight.

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How Does D-Mannose Help With Bladder Infection?
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Date: February 28, 2012 07:57 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does D-Mannose Help With Bladder Infection?

D-Mannose

Typically, it is the accumulation of the Escherichia coli (E coli) bacterium in the bladder, kidneys, urethra or ureters that results in bladder, kidney and urinary tract infections. The strange part is that the intestines naturally contain the E coli bacteria in them, and they do not cause any harm while they are present there. However, distressing infections can be caused by these bacteria if they stick to the lining of the urinary tract by somehow reaching into the kidneys.

At one time, bladder, kidney and urinary tract infections were treated using antibiotics; however, the only problem was that even friendly bacteria were removed from the body as well. People became prone to upset stomach and women, in particular, would frequently catch yeast infections because of this. Thus, D-Mannose was discovered as a means of treating these infections of the urinary tract without killing the friendly bacteria.

What is D-Mannose and How Was it Discovered?

D-Mannose is basically a sugar that naturally occurs in fruits like apples, berries and peaches. It was back in the late 1980s that this sugar monomer was discovered. Research has shown that this sugar has defensive qualities, and it can offer protection against pathogenic bacteria. Currently, nutritional supplements containing Mannose can be found at health stores, online retailers and supermarkets. Any supplement containing D-Mannose will be capable of flushing out harmful bacteria from the kidneys, urinary bladder and tract. Therefore, these supplements are the ideal remedy for infections that typically occur there.

How Does D-Mannose Help Cure Bladder and Other Infections?

Basically, the body is not able to absorb D-Mannose easily. Therefore, once people take supplements containing this constituent it eventually Reaches the kidneys and the urinary bladder. Since the E. coli bacteria that cause urinary tract infections stick to the tissue lining in the urinary tract, therefore, by actively binding to the bacteria, these infections are prevented from occurring. The remaining redundant bacteria that are flushed out of the kidneys and the urinary tract simply pass out through the urine.

In What Forms is D-Mannose Available?

This beneficial substance can be purchased by consumers in the form of a dissolvable powder or capsule supplements. It is recommended by a majority of manufacturers, who are manufacturing products containing this substance that one to three doses per day should be taken with a single glass of water each time. There are minimal risks of overdosing when taking D-mannose and there are no possible side effects that people might suffer from by using this substance as a remedy for urinary bladder and tract infections.

Patients will not be discouraged from using supplements containing this substance even by doctors since they are aware that it is safe to take them, and no side effects are associated. In fact, the purest form of this sugar monomer is the easiest and safest to use. Whether people choose to use powders or supplements, the effectiveness will actually depend on the manufacturer the product is coming from. Thus, when it comes to fighting off urinary bladder and tract infection, D-Mannose is indeed an effective treatment as long as the right powder or supplement is selected.

Get some D-mannose today and stop your bladder infections in its tracts.

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What Liver Blend Does For You
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Date: November 26, 2011 03:43 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Liver Blend Does For You

Liver blend is a powerful combination of herbs that help maintain the health of your liver, help to restore it when it has been damaged by alcohols and pharmaceuticals such as acetominophen (paracetamol and Tylenol) and also detox your body, purifying the blood before it Reaches the liver. Your liver is an extremely important major organ, being responsible not only for metabolizing toxins and drugs, but is also your body's chemical processing plant, manufacturing enzymes and the bile needed for effective digestion.

Liver Blend not only supports your liver, but also your gall bladder that is used to store bile and release it into the duodenum as part of your digestive process when necessary. By maintaining a healthy liver and gall bladder, and restoring the liver when damaged, Liver Blend helps you maintain a healthy digestive system and remain healthy yourself.

It is also a diuretic that promotes the urination that washes away many of the toxins that pass through the kidneys, and in so doing helps to keep your kidneys healthy. A useful side-effect is its support for your endocrine system, so in total, Liver Blends supports the liver, gall bladder and kidneys and also helps to maintain a healthy hormone system - in total, an amazing combination of healthful properties for an amazing mixture of natural herbs.

Liver Blend as a Powerful Diuretic

In addition to offering a powerful synergistic blend of substances that help detoxify your liver and protect is from damage caused by pharmaceuticals and alcohol, Liver Blend can also help your liver to regenerate and build new cells to replace those damaged by toxins. It is therefore both protective to your liver and regenerative. However, it also possesses powerful diuretic properties, largely through its flavonoid content, such as those present in the bitter oils contained in dandelion.

Burdock, too, is highly diuretic, and dandelion and burdock are frequently used together to help promote the urination that flushes toxins from your body and purifies your blood and your liver. Not only that, but dandelion contains large quantities of potassium, a mineral that can be depleted in the kidneys as they rid your body of toxins. This is restored by the dandelion in Liver Blend. Diuretics are important components of any detox program, and also essential in maintaining liver health, and Liver Blend provides a powerful mix of diuretics in the dandelion and burdock it contains.

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Fight Pain Improve Blood Sugar And Heart Health with OPC Pine Bark Extract
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Date: June 07, 2011 11:36 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Fight Pain Improve Blood Sugar And Heart Health with OPC Pine Bark Extract

How Does OPC Pine Bark Boost Your Health?

OPC pine bark has become increasingly popular in the supplement industry due to obvious reasons. It is one of the best antioxidant formulas available today. There has been so much research involved in its development, and the studies that followed have published largely positive results. In the past few years it has received a lot of good press, which has significantly contributed to its commercial success.

OPC stands for oligomeric proanthocyanidin, a class of flavonoids. OPC has been in use as a nutritional supplement since the 1980s. To this day, it remains an important source of polyphenolic antioxidants. Moreover, it has been linked to a diverse variety of health benefits, and laboratory studies concerning its effects on human health are well publicized. Pine bark extracts are one of its best known sources.

Promotes Heart Health

OPC pine bark has long been associated with heart health. For one, it has shown to help lower lipid levels in the blood, including cholesterol, triglycerides, and lipoproteins. It interferes with the productions of bad cholesterol into the blood and protects the blood vessels from lipid peroxidation.

In addition, it facilitates normal flow of blood and combats chronic venous insufficiency. It contributes to the upkeep of blood vessel walls and keeps the veins and arteries in prime working condition. By so doing, it promotes proper circulation to the deepest Reaches of the body and back to the heart.

Improves Kidney Function

OPC pine bark is particularly good for the kidney as it appears to improve renal function, especially in the context of metabolic syndrome. Central obesity, insulin resistance, diabetes mellitus, and high blood pressure are all symptoms of metabolic syndrome, which takes its toll on the kidneys.

Kidney problems have been observed in people with elevated levels of albumin in the urine. When filters of the kidney are damaged, proteins from the blood such as albumin leak into the urine. OPC pine bark restores health to the capillaries in the kidneys that filters waste materials from the blood.

Counteracts Pain Chemicals

Sufferers of joint pain are likely to benefit from OPC pine bark. Joint pain is often tied to osteoarthritis, the most common form arthritis. It is often accompanied by stiffness and reduced mobility. OPC pine bark has been used as a therapeutic treatment for osteoarthritis and other causes of joint pain.

There is good evidence that OPC pine bark is effective in counteracting pain chemicals and relieving inflammatory pain. In several randomized, double blind, placebo controlled studies, regular intake of OPC improved joint pain and stiffness, reduced reliance on analgesics, enhanced physical function.

Prevents Oxidative Stress

OPC pine bark is free radical scavenger, first and foremost. It is arguably the most researched plant polyphenol largely owing to its potent antioxidant capacity. As an antioxidant, it prevents radical damage from progressing to oxidative stress and promotes cellular longevity.

OPC Pine bark may also help manage blood sugar. What is stopping you from taking OPC pine back daily?

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How Does Glutathione Work in the Body to Detox
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Date: May 06, 2011 10:11 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does Glutathione Work in the Body to Detox

Glutathione a Body Detox

Glutathione belongs to the category of antioxidants that the human body can synthesize. It is an organic compound that is quite pervasive in nature as it is found in many multicellular organisms, microscopic or not. Almost all plants and animals are capable of producing glutathione, and, like human beings, they utilize this substance to neutralize free radicals and detoxify heavy metals.

Scavenges Free Radicals

It is common knowledge that free radicals are harmful to our body. It damages tissues, proteins, and even DNA. Free radicals are highly reactive by-products of cellular respiration. Cells utilize oxygen to power their activities, but in the process produce a group of compounds called reactive oxygen species, which change into radicals, harming cell organelles when not disposed of and raising cellular toxicity.

Glutathione is in the employ of every cell, for it is a fundamental part of the antioxidant defense of cells. Throughout the body, it is usually found in its reduced form, which donates reducing equivalents to reactive oxygen species. Glutathione becomes reactive in the process, but easily reacts with other reactive glutathione to form glutathione disulfide. Antioxidant enzymes manufacture glutathione in the presence of glutathione disulfide. This process constitutes the antioxidant mechanism of all cells.

Detoxifies Liver Metabolites

Metabolism is a complex process. Bioactive compounds in the foods we eat produce metabolites and by-products that are not necessarily good for our health. In fact, most of the drugs and medications we take directly harm us. Fortunately, the liver comes to our defense. For example, alcohol is converted into large amounts of acetaldehyde in its first stage of metabolism, creating effects we usually refer to as hangover.

The presence of glutathione enables the liver to easily recuperate from the damages brought on by harmful metabolites. That being said, glutathione in its reduced form does get depleted. One good example is drug overdose. The analgesic paracetamol, or acetaminophen, is known for its toxic by-product that induces liver failure in the absence of glutathione. Drugs are immediately detoxified in the liver with the help of glutathione. Low levels of glutathione may even result in death as is the case with paracetamol overdose.

Expels Foreign Materials

A number of substances in our diet are considered xenobiotics, or foreign materials, by our body. Most of them passes the alimentary canal undigested and enters the colon together with waste materials. However, there are substances that readily undergo absorption in the small intestines, such as trace elements and heavy metals. They pose considerable threats to health when they enter the systemic circulation in large quantities.

Glutathione is one of the compounds that keep xenobiotics in check. It facilitates the excretion of heavy metals and many known toxins. Glutathione conjugation plays a major role in detoxification and quite common at the cellular level. It makes sure that foreign compounds do not undergo reabsorption once it Reaches the kidneys, effectively washing them away through the urine.

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How to detoxify from heavy metal aluminum toxitity
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Date: November 09, 2010 06:04 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How to detoxify from heavy metal aluminum toxitity

nacAlthough aluminum is not a heavy metal, it can be toxic if present in excessive amounts or small amounts if it is deposited in the brain. Many of the symptoms of aluminum toxicity are similar to those of Alzheimer’s disease and osteoporosis. Aluminum toxicity can often lead to colic, rickets, gastrointestinal disturbances, poor calcium metabolism, extreme nervousness, anemia, headaches, decreased liver and kidney function, forgetfulness, speech disturbances, memory loss, softening of the bones, and weak, aching muscles. Since aluminum is excreted through the kidneys, toxic amounts of aluminum can often impair kidney function.

When aluminum salts accumulate in the brain, seizures and reduced mental function can often result. In order to reach the brain, aluminum must pass the blood-brain barrier, which is an elaborate structure that filters the blood before it Reaches the vital organ. Although elemental aluminum does not ordinarily pass through this barrier, certain aluminum compounds, such as aluminum fluoride, will. Many municipal water supplies are treated with aluminum sulfate and fluoride. These two chemicals readily combine with each other in the blood and are poorly excreted in the urine. The absorption of high levels of aluminum and silicon in the intestines can result in the formation of compounds that accumulate in the cerebral cortex and prevent nerve impulses from being carried to and from the brain in the proper manner. This situation can be aggravated by a chronic calcium deficiency.

People who have spent their career in aluminum smelting plants for long periods have been known to experience dizziness, impaired coordination, and a loss of balance and energy. When aluminum accumulates in the brain, the above symptoms are often caused. Perhaps the most alarming thing to note it that there is evidence to suggest that long-term accumulation of aluminum in the brain may contribute to the development of Alzheimer’s disease. It has been estimated that an ordinary person ingests about 3 and 10 milligrams of aluminum a day. Aluminum, being the most abundant metallic element in the earth’s crust, is primarily absorbed in the body through the digestive tract, but can also be absorbed through the lungs and skin. Additionally, aluminum can be absorbed by and accumulate in the body tissues. Since aluminum permeates our air, water, and soil, it can be found naturally in varying amounts in almost all food and water. Aluminum is also used to make cookware, cooking utensils, and foil, along with being present in many other everyday products including over-the-counter painkillers, anti-inflammatories, douche preparations, antacids, baking powder, food processing, antiperspirants, toothpaste, dental amalgams, bleached flour, grated cheese, table salt, beer, and municipal water supplies.

The following nutrients are very helpful when dealing with aluminum toxicity: apple pectin, calcium, magnesium, coenzyme A, garlic, kelp, lecithin capsules or granules, l-glutathione, a multivitamin and mineral complex, SAMe, vitamin B complex, N-Acetyl Cysteine, and vitamin E. Additionally, the following herbs are great for blocking damage to the body from toxic heavy metals and radiation when taken regularly: burdock root, Echinacea, ginseng, ginkgo biloba, and fiber. Other recommendations to help prevent aluminum toxicity include maintaining a diet that is high in fiber and includes apple pectin; using only stainless steel, glass, or iron cookware, with stainless steel being the best; and being aware of the products that contain aluminum by reading labels and avoiding those that contain aluminum. Sulfur container foods like N-Acetyl Cysteine can help find up heavy metals and eliminate them from the body. If you suspect you have heavy metal toxicity, consult your health care provider immediately.

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Cascara sagrada and constipation
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Date: November 09, 2010 05:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Cascara sagrada and constipation

bark of cascaraCascara Sagrada is a large deciduous herbal tree. It is found in the specific area of the western coastal regions of the North America, mainly along the bottomlands in the valleys, along canyons and forested mountain slopes. It is also found growing along the Pacific Northwest from the Canadian province of British Columbia down to the northern parts of the California state. It Reaches to the height of twenty to thirty feet and circumference of one and a half feet in diameter at maturity. With slender branches having many leaves, the bark of the tree is reddish brown is colour.

The leaves are green and yellow in colour and elliptical in shape with finely toothed edge, rounded base and sharp or blunt tips. Along the slender branches, the foliage tends to be guided by the crowding of the leaves at the tips of the branch lets. During the months of May to June, it bears greenish white flowers which are borne in clusters along the axils of the leaves. The flowers by the month of September gives rounded black fruits, which bear two or three smooth seeds. The various parts of the tree were used by the Native Americans in their traditional folk medicine.

The Spanish on observing this named the tree as Cascara Sagrada, meaning the “Sacred bark”. In the traditional Indian medicine it was used in preparing various herbal medicines. In the autumn season the bark of the tree would be stripped, dried and then be left to a slow aging process at least for a year. The prepared bark was then kept in water and boiled to the steep. The boiled water was cooled and drunk as a potent herbal medicine to alleviate the symptoms of constipation in affected patients.

plant of cascaraIn the year 1877 the American physicians recognized and accepted its many medicinal benefits. From the year 1894 they started listing Cascara Sagrada in the books U.S. Pharmacopeia for the significant medical benefits it provided. It is believed to be one of the world’s most naturally available laxatives and is still marketed as a natural plant based laxative. The wave like contractions it causes along the musculature in the walls of the intestine for alleviating constipation is the ultimate medicinal ability It possess which no other modern medicine has.

It is known for the peristalsis forces that it creates to tone the relaxed intestinal muscles of the affected patients. It shows great results by irritating the intestinal tissues. In old and weakened people is shows potent laxative action when properly diluted, providing great relief. The honey made from the flowers of this tree also show laxative action but is mild in nature. It is believed that the milder laxative action produced by the combination two related European species of Cascara is safe and beneficial to patients.

This herbal tree is widely used in patients with chronic constipation. Many commercial laxatives contain the bark of this herbal tree as the key ingredient of the product. If you suffer from constipation please contact your health care provider. Laxatives are a temporary fix for constipation and should not be taken for long periods of time. Lack of bowel movement is usually due to low fiber diets. Adding additional fiber to ones diet can boost bowel function and reduce constipation.

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Black Walnut
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Date: June 05, 2009 10:13 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Black Walnut

Black walnut is a species of flowering tree in the hickory family. This plant grows mostly from southern Ontario, west to southeast South Dakota, south to Georgia, northern Florida, and southwest to central Texas. The black walnut is large tree that Reaches heights of 30 to 40 feet. The bark is grey-black and deeply furrowed. The leaves are alternate are about 30-60 centimeters in length. The male flowers droop to about eight to ten centimeters long, while the female flowers are terminal and can be found in clusters of two to five. These flowers ripen during the autumn into a fruit that has a brownish-green, semi-fleshy hush, and brown nut. The whole fruit falls in October. Although native to the Midwest and east central United States, the black walnut tree was introduced into Europe in 1629. Black walnut is more resistant to frost than the English walnut, but it thrives best in the warmer regions of fertile, lowland soils with a high water table. The nuts are harvested by hand from wild trees, with about 65% of the annual wild harvest coming from the U.S. state of Missouri.

For centuries, black walnut has been used in Europe to treat skin ailments and constipation. Recent research has led to findings that support its use for skin problems like boils, eczema, herpes, and ringworm. Additionally, it has many benefits for the stomach that are well represented. Black walnut was used by Native Americans as a laxative. Additionally, black walnut was used as a remedy for diarrhea and dysentery during the Civil War.

Black walnut has also been used for syphilis, TB, varicose veins, chronic infections of the intestines, and urogenital problems. Black walnut is considered to be very useful for killing parasites, tapeworms, and ringworm by herbalists. This nutrient causes oxygenation of the blood, which kills parasites. This fact has been proven through recent research. The brown stain that is found in the green husk of the black walnut is known to contain organic iodine, which has both antiseptic and healing properties.

It has been determined by scientific research that black walnut contains astringent properties that are healing to the skin and mucous membranes of the body. Black walnut can be gargled to clean stains on the teeth as well.

The hulls and leaves of the black walnut plant are used to provide alterative, anthelmintic, antigalactagogue, antineoplastic, antiseptic, astringent, and vulnerary properties. The primary nutrients found in black walnut are calcium, chlorine, iron, magnesium, manganese, niacin, organic iodine, phosphorus, potassium, selenium, silicon, selenium, vitamin A, B1, B2, B6, B15, C, P, and bioflavonoids. Primarily, black walnut is extremely beneficial in treating athlete’s foot, Candidiasis, canker sores, cold sores, dandruff, fungus, gum disease, herpes, infection, malaria, parasites, rashes, ringworm, and tapeworm.

Additionally, this herb is also extremely helpful in dealing with abscesses, acne, asthma, body odor, boils, cancer, colitis, diarrhea, diphtheria, dysentery, eczema, eye diseases, fevers, hemorrhoids, liver disorders, lupus, poison ivy, skin diseases, tonsillitis, primary tuberculosis, tumors, ulcers, varicose veins, and wounds. For more information on the many beneficial effects of black walnut, please contact a representative from your local health food store with questions. Black walnut is available in capsule and tablet forms at your local or internet health food store.

*Statements contained herein have not been evaluated by the Food and Drug Administration. Black walnut is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.

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Hoodia Gordonii
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Date: December 10, 2008 10:48 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Hoodia Gordonii

Hoodia Gordonii is a South African succulent plant of the family Apocynaceae. They are remarkable similar in appearance to cacti, although they are totally unrelated to them and grow predominantly in the region of Central Namibia in the south west of Africa, up to the southern regions of Angola. They are most commonly found in rocky ground and on the plains.

There are several species of hoodia, some of them grown domestically, and it is Hoodia gordonii that is used as an appetite suppressant in hoodia weight loss pills. Although the plant has historically found use in the treatment of infections and gastric problems, most interest is displayed in its use by the bushmen of the Kalahari Desert to suppress their appetite during long hunting trips when food and water are scarce.

The active ingredient was isolated in 1977, and given the name P57: the product is therefore often referred to as Hoodia P57. It was patented by its discoverers, the CSIR (South African Council for Scientific and Industrial Research) and a license granted to UK company Phytopram, who worked together with Pfizer to isolate the active ingredients and manufacture them synthetically. This was found to be very difficult, if not impossible, since any synthetic form of the extract failed to display any hunger-suppressant properties.

Finally, the rights to the main ingredient were released by Pfizer in 2002, thus indicating that it was of no commercial benefit to them. The main problem they admitted with synthesizing P57 was not only the difficulty in doing so, but also that there were side effects of the extract on the liver caused by other components that could not be removed. No synthetic form of hoodia is therefore available, and only the natural plant is used in current Hoodia 57 preparations.

The rights of the San Bushmen to the plant were recognized by the CSIR in 2002, and not only do they receive a proportion of the profits of marketing hoodia, but also the plant is protected with wild-harvesting licenses provided to only certain individuals and companies. Due to the rising popularity of the hoodia weight loss industry, the plant has been named as an endangered species in the wild.

It is believed that the active ingredients are steroidal saponins that can fool the body into believing it is full. This theory is based upon the effect on appetite of glucose concentrations in the blood. Your appetite is controlled by the amount of unconverted glucose in your blood, and glycogen in the liver. When you eat carbohydrates, they are digested and converted into glucose which is absorbed into the bloodstream.

Under normal conditions your blood glucose levels increase to a level where a signal from hypothalamus stops you feeling hungry. Insulin is then secreted from the pancreas to prepare your cells to use that glucose in the mitochondria to create energy by means of the Kreb's Cycle, or Citric Acid Cycle as it is also known. This reduces the concentration of glucose in the blood, and once it Reaches a certain level the body begins to use its emergency energy supply, glycogen, that is stored in the liver.

A signal then informs the brain that more glucose is needed. You then feel hungry again, and this cycle is repeated several times a day in a normally healthy person. This cycle is controlled by certain hormones in the brain, specifically in the ventromedial center of the hypothalamus, where it is believed that the ATP (adenosine triphosphate) availability controls the release of the hormones involved.

ATP is the molecule of energy, and as the concentration of blood glucose and of glycogen drop, then the amount of ATP produced also drops and this is detected in the hypothalamus, which reacts by releasing ghrelin. Increased leptin increases the feeling of satiety and ghrelin increases the feeling of hunger. Serotonin acts on the brain to increase the effect of leptin in the hypothalamus, and therefore make us feel less hungry, or more satiated.

It is believed that hoodia gordonii, or the Hoodia P57 component of it, fools the brain into believing that your blood glucose or glycogen levels have reached the point at which it should trigger a satiated response, so that you stop eating even though your ATP levels might be low. The steroidal saponins that it contains is believed to be ten thousand times more effective than glucose in stimulated the secretion of serotonin.

Hoodia has also been found to contain a number of glycosides, including pregnane glycosides that some studies have indicated to help control appetite of the subjects tested. Most of these tests have been carried out on animals, although Hoodia weight loss preparations are offered in a form standardized on both steroidal saponins and pregnane glycosides.

Hoodia gordonii is becoming so popular as a weight loss product that its export is being monitored by the South African government. It has become so endangered that, since 2005, only hoodia grown on commercial farms is permitted an export license, and exporters must obtain a license from the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). Importers also require a permit from the US department of Agriculture, and a CITES certificate is also needed to re-export the finished product.

Because of this, more hoodia weight loss pills are being sold than there is hoodia gordonii to produce them. It is not uncommon for cacti such as the prickly pear cactus from Mexico, to be used, or for low concentrations of hoodia to be bulked up with fillers. Neither of these is of any use as an appetite suppressant, the former having no active ingredients whatsoever and the latter containing only traces.

If you are purchasing hoodia, therefore, be aware of this. Request sight of the CITES certificate and USDA permit, and also the analysis results by an authorized laboratory to confirm that the product is what it purports to be. Otherwise, there is some evidence that Hoodia gordonii can help you reduce weight, although to date there are only four recognized analytical laboratories registered to analyze the active content of hoodia weight loss products.

Finally, check for the analysis certificates. All Hoodia weight loss products should be analyzed by each of three methods: Microscopy, High Performance Thin Layer Chromatography (HPTLC) and High Performance Liquid Chromatography (HPLC) - all there are needed. The four authorized laboratories are: the University of Mississippi, Chromadex labs in Irvine California, Alkemist Pharmaceuticals and Advanced Laboratories, Smithfield, NC.

No others will do, so if your Hoodia weight loss preparation has not been analyzed using the three methods by one of these laboratories, don't buy it, even if it can show the CITES and USDA documentation.



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Guar Gum Fiber
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Date: October 27, 2008 04:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Guar Gum Fiber

Guar gum is what is known as a soluble fiber, and it is well known that it promotes a healthy colon. You will not find soluble fiber in what you believe to be 'high fiber foods', yet it is a very important part of your diet, particularly if you have problems with your colon such as Irritable Bowel Syndrome (IBS) or even colon cancer.

Traditional high fiber foods, such as bran, leafy vegetables and cereals, contain insoluble fiber that mechanically act as an aid to digestion and the movement of your food through your gastrointestinal system. Soluble fiber, on the other hand, is found in what are more commonly regarded as starchy foods, although unlike starch, the chemical bonds that attach the various sugar molecules together cannot be broken by the acids and enzymes used by your gastric system to digest them.

They thus pass through the body undigested, in the same way as insoluble fibers, and so contribute to the mechanical system upon which the peristaltic pumping motion of the intestine depends. Because it is not digested, soluble fiber contains practically no calories since it does not contribute to the metabolism of your body. Fiber imparts many benefits in addition to enabling your intestine peristalsis to move your food through your digestive system.

For a start they don't contribute to your nutrition, either negatively or positively, but provide bulk to what you eat and provide help to your bowel movements by giving the intestinal muscles something to bite on. One of the benefits of such foods is their effect on your blood sugar and preventing the onset of diabetes. They can also help you to avoid obesity through providing virtually calorie-free bulk to your meals. Some fibers can bind chemically to toxins and certain fats, and can clean out your colon. So what's the benefit of soluble fiber over the insoluble type, and where does guar gum enter the equation?

Basically, soluble fiber is water soluble while insoluble fiber is not. Insoluble fiber is contained in cereals, beans and peas, fruits and in fact anything that doesn't dissolve in water, even when acted upon by that concentrated hydrochloric acid that is the basis of your digestive juices. Soluble fiber can help to prolonging the time that your stomach acids and enzymes spend in digesting your food. Soluble fiber is reported as conferring many health benefits, and guar gum and pectin are two of its major forms.

Guar gum is obtained from the guar bean, indigenous to India and Pakistan, but also grown in the USA, China Africa and Australia. The bean is edible to humans, and also used as cattle feed and fertilizer. TO obtain the gum, the seeds are dehusked and milled, and the gum is a whitish powder, not gummy as you might believe. However, when dissolved in water it gels when it comes into contact with calcium or borax.

It is effective as a laxative, due to the bulk it forms when dissolved in water, and can relieve not only constipation, but is also an effective treatment for IBS, Crohn's disease, colitis and other conditions of the lower digestive tract. Because it enables the colon to eject toxins and other undesirable waste products much more rapidly, guar gum is good for the health of your colon, and absorbs not only toxins but also undesirable bacteria.

Guar gum is what is known as thermogenic: it helps your body to burn fat by converting it to energy, with a resulting increase in your body heat. Not only that, but because it contains very little calorie content, it can bulk up a meal, help to make you feel satisfied and lower the glycemic index of your meal. It is used in many types of weight loss products and diets, although its uncontrolled use can be dangerous due to the potential blockage of your esophagus through insufficient fluid intake. For that single reason you are unable to purchase guar gum in non-prescriptive weight loss products.

Another of the benefits of soluble fiber, and guar gum in particular, is that it accelerates the absorption of calcium in the colon. Since calcium is normally absorbed in the small intestine, as opposed to the colon, this is good news for those seeking to lose weight. The reason for that is that the dairy products which traditionally contain most calcium tend to be high in calories, and guar gum enables you to get your RDA of calcium from a diet lower in these products by maximizing the calcium extraction and absorption right through the intestinal tract, and not only in the small intestine.

It has also been found to improve your tolerance to glucose. One of the problems that diabetics have is that sugars are absorbed mainly in the small intestine, whereas guar gum also enables it to be absorbed in the colon. Therefore, while the overall absorption level remains constant, there are no peaks and troughs since the absorption is constant through the entire intestinal tract rather than all the demand being in the small intestine. There is therefore less of a demand for insulin at certain times after a meal, so that the overall level of blood insulin can be reduced.

Guar gum is used as a delivery medium for certain drugs. Where it is desirable for a drug to be released into the colon as opposed to any other part of the gastrointestinal tract, this is the ideal substance. Guar gum can be degraded, if not digested, by anaerobic bacteria (bacteria that live in the absence of oxygen). Certain drugs can be attached to the guar gum molecule, and after consumption will pass unchanged through the stomach, duodenum and small intestine.

However, when it Reaches the colon, the anaerobic bacteria that populate the large intestine degrade the gum, and release the drug molecules into the colon where they are needed. There are a number of delivery techniques in addition to using the gum itself, including using derivatives of guar gum, using a combination of the gum and other polymers and also multiparticulate delivery techniques.

Partially hydrolyzed guar gum also seems to increase the population of your bowel with friendly bacteria, or probiotics, such as lactobacilli and bifidobacteria. These can help to prevent or reduce the symptoms of many bowel conditions, and probiotic drinks taken with guar gum can be extremely beneficial to people suffering the symptoms of irritable bowel syndrome and other similar disorders of the lower intestinal tract.

So if you have a disorder of your lower intestine or colon, try a soluble fiber such as guar gum as a natural treatment, and where appropriate also take that with a probiotic. Most people find that their symptoms improve and in many cases they disappear altogether.



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Acidophilus
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Date: August 23, 2008 11:59 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Acidophilus

Acidophilus is correctly named Lactobacillus acidophilus, and is one species of Lacobacillus used commercially in the preparation of certain types of yoghurt. The name refers to the fact it is found in milk (lacto), is rod-like in shape like many bacteria (bacillus) and it likes acidic conditions (acidophilus). It not only likes them, but creates them.

In fact, acidophilus thrives at a pH of 4-5 or less, and occurs naturally in the gastrointestinal tract of humans and animals, and also the mouth and vagina. It ferments milk to lactic acid, and dies in the presence of sunlight, excessive moisture and at high temperatures. Some, but not all, strains are probiotic, or ‘friendly’ bacteria that aid digestion and help to protect against harmful bacteria and their toxic emissions.

The fermentation of nutrients by friendly bacteria produce acids, such as the lactic acid previously referred to, hydrogen peroxide and other substances hostile to harmful organisms, and also reduces the population of harmful bacteria by competing for their food. There are additional health benefits that shall be discussed later, but first some comments about the stability of acidophilus to heat.

The growth rate of acidophilus Reaches an optimum at around 36-37F (2.2C), and it tends to die off at temperatures much above this over a period of time. It also tends to be sensitive to oxygen and moisture, and if exposed to heat, moisture and oxygen, a supplement will lose its potency over time. This is true of all such supplements, and after purchase must be quickly refrigerated. It is possible, however, to purchase stabilized forms of acidophilus that die off slower than normal. This extra resistance is built in during the manufacturing process, and many forms of acidophilus claim to be stable. Although there will never be a truly stable form of the probiotic, these stabilized versions do last longer than those not claimed to be so.

During manufacture, the bacteria are first concentrated by removing the excess liquid by means of sedimentation, ultra-filtration, reverse osmosis and centrifuging. A substance is then added to protect the bacteria from the shock of freezing and the acidophilus freeze dried. A stabilizer is then added to maintain its properties between freezing and consumption.

It has also been found that bacteria grown at higher pH levels last longer than those at lower pH. The packaging is also important, and since the bacteria are sensitive to oxygen, nitrogen flushing the bottles will improve the stability of the product. Glass bottles are less porous than plastic, and so is the preferred packaging material for maximum stability and life. Another factor is refrigeration. If you keep the bottle in the fridge it was last a lot longer than at room temperature, but take care not to freeze it since acidophilus does not freeze well. If it is not refrigerated then it will quickly lose its potency.

The form in which you take the supplement is immaterial regarding the potency: at least initially. However, through time the powder will become less potent quicker, because it will adsorb oxygen and moisture. Otherwise the form in which it used is immaterial. So, yes, acidophilus can be stabilized, but only for a while, and if allowed to warm up to room temperature in the presence of oxygen will quickly degrade, although this takes more than just a day or two.

Many health benefits are claimed for Lactobacillus acidophilus, although your daily consumption to achieve these should be at least 2 billion CFU, and preferably 5 billion. You can also fortify the bacteria with a prebiotic of fructooligosaccharides (FOS). These provide nutrition for the acidophilus and accelerate its growth.

One thing to be careful of is assuming that yoghurt contains acidophilus. It does not contain sufficient to be of benefit to you. Commercial yoghurt acidifies over time and kills off the bacteria, so commercial yoghurt sitting on a supermarket shelf has very little beneficial bacterial content. Natural yoghurt is better, and certainly contains beneficial bacteria, but not enough to make a significant difference. A supplement is therefore needed if you are to keep your intestinal tract sufficiently healthy. If you cannot take dairy products, acidophilus is available in non-dairy form. The major health benefits they impart are:

1. Digestive Problems.

Acidophilus can control many types of digestive disorder, particularly traveler’s diarrhea. In fact if you are traveling to countries where drinking water might be a problem, also take some acidophilus and this will tend to prevent you from becoming ill. Even if you drink bottled water, there are still washed salads, beverages made with local water and showers and the like whereby you could ingest some dodgy water.

2. Constipation

Acidophilus, especially when supported by FOS, helps both to hydrate the feces, and improve their transport through the colon, an also to improve the general health and well-being of your entire intestinal system.

3. Yeast Infections (Candidiasis)

Acidophilus possess antifungal properties that kill off yeasts, particularly Candida albicans found in the vagina. This is due to the lactic acid produced by the bacteria, and there is evidence that gastrointestinal yeasts are affected in the same way by the oral probiotic. Furthermore, when bacteria and yeasts are killed off by medication, including friendly bacteria, the sites they occupied on the intestinal walls become free and acidophilus should be present to take these up and prevent any more yeast or bacterial infections. That is one reason why probiotics should be taken immediately after a course of antibiotic treatment.

4. Immune System Support

Lactobacillus acidophilus is believed to modify the balance of microbes in the intestine so as to lead to an enhanced production of antibodies, and white blood cells with increased phagocytic activity. The bacteria also appear to have some reducing properties, which can also give support to the immune system through the resultant antioxidant properties.

However, by far the most important property of probiotics are their properties in acidifying the intestinal tract, and so rendering them less attractive to harmful pathogens, and in producing hydrogen peroxide which has a similar effect. They also produce natural antibiotics, and there is now doubt that a supplement of acidophilus will provide you with several health benefits and also make you feel fitter and more alert.



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Garcinia Cambogia
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Date: July 08, 2008 03:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Garcinia Cambogia

Garcinia cambogia is a small tree bearing a small pumpkin-like fruit of the citrus family, and is steadily appearing in an increasing number of weight loss supplements. It is indigenous to parts of Africa and Asia, and the rind is commonly used in Indian cookery.

Although the fruit is particularly sour to the taste, it is used in form of an extract of the rind and claimed to act as an appetite suppressant and also to increase the body’s capacity to metabolize fat. Although there are conflicting claims being made about its efficacy, or lack of it, research shows that it definitely has promise as an agent to prevent and fight obesity and its use is steadily increasing in this respect.

The active ingredient is hydroxy citric acid, otherwise known as HCA, contained in the form of the potassium and calcium salts of the acid in the aqueous extract of the garcinia cambogia rind. It forms up to 30% by weight of the rind. It is tasteless and odorless, and so far found to have no toxic effects on humans. Animal studies have also been generally favorable.

HCA works in two specific ways both to reduce the desire to eat and to inhibit the storage of fat in the body. In each case, as with so many supplements that have an inhibitory effect on a physiological or psychological function or on a metabolic process, it involves an interaction with enzymes.

Citrate lysase is an enzyme in the body that helps to prevent lipogenesis and instead promotes the conversion of carbohydrates into fat. When this enzyme is inhibited from carrying out its intended part in the body’s metabolism, the process of carbohydrate oxidation is boosted, or, in other words, the excess carbohydrate is burned off, or changed into energy.

More fats could also be expelled unchanged from the body, but irrespective of that the end result is that less carbohydrate tends to be converted to fat. Garcinia cambogia, however, has not been found to reduce the body’s uptake of essential fatty acids which are necessary for health. Had this occurred, you would feel a raging hunger as opposed to the appetite suppressing properties the extract is claimed to have.

The oxidation of carbohydrates can also lead to thermogenesis, or the boosting of the metabolism by increasing your body temperature. An increase in the metabolic rate helps weight reduction through an increased calorie demand while your body is at rest. However, that is not the only way in which the HCA extract works to help reduce your weight, or at least help to maintain it at a healthy level. Let’s return to its specific appetite suppression properties.

Serotonin (5-hydroxytryptamine) is a neuroreceptor found in the central nervous system. It has many regulatory effects on the body, one of which is appetite. Although it is by no means the only chemical in the body that has an effect on the appetite, serotonin is a significant factor. As you get hungry, serotonin is released in the hypothalamus, an area of the brain that regulates sleep and eating. The release of serotonin increases when you see and or smell food. It is the agent that starts canine salivation, and a ravenous hunger in those that have no immediate access to food.

It also causes you to snack, and, as you eat, the serotonin level in the hypothalamus continues to increase until it Reaches a point where it provides the hypothalamus with a feeling of repletion or satisfaction. You then stop eating. So the more serotonin is produced, the quicker you stop feeling hungry.

Garcinia cambogia extract has the effect of stimulating the emission of serotonin into the hypothalamus, and so suppresses your hunger quicker. You don’t stop eating altogether, but attain that feeling of satisfaction much quicker and so tend to eat less with each meal. This can not only help you maintain your weight at a healthy level, but also to reduce weight in the obese.

Although the extract can work through each of these mechanisms, it does not have such a significant effect on a very fatty diet. It can help if you switch to a relatively healthy diet, lower in fats, but the effect might not be strong enough to compensate for a poor diet in terms of fat content.

Studies have indicated an anti-oxidant activity that likely comes from the xanthones and xanthone derivatives that are also contained in the fruit. In fact there are other recorded uses of garcinia cambogia, and it has been used in traditional Indian medicine to treat fevers, dysentery, open wounds, ulcers and tumors.

According to a study carried out for the National Cancer Institute there is no documented toxicity effects on humans, and there is no regulation regarding the use of garcinia cambogia. It has not been evaluated by the FDA.

However, there are contra-indications in the case of pregnant and lactating women, more as a safety measure than for any particularly known risk. Alzheimer patients should avoid taking HCA since there is a possibility of it promoting the synthesis of acetylcholine in the brain, and its glycemic action renders it unsuitable for diabetics.

Conversely, this same action is a positive benefit by reducing the craving of healthy adults for sweet foods. However, HCA is frequently taken in combination with chromium due to the latter’s positive effect on the regulation of blood sugar levels. Nevertheless, diabetics should avoid any supplement containing chromium without professional medical advice.

The supplement should be standardized on the HCA content, and an average dose is around 500 mg – 1000 mg of 50% extract a day. However, this varies, and the most important aspect of such extracts is that when changing brands; be sure to compare the strength of the relative extracts and change your dosage accordingly.

Although the benefits of garcinia cambogia to those seeking to lose weight are debated, there is ample evidence to suggest that a regular intake of the extract is beneficial – and not only with respect to the maintenance of healthy weight.

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Licorice Root
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Date: May 23, 2008 11:53 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Licorice Root

Medical professionals, especially in Europe and Japan, have been using licorice more and more in medicine. The Chinese consider licorice to be a superior balancing and harmonizing agent, so it is added to many herbal formulas. It is reputed in many countries, including the United States, to be a treatment for stomach, intestinal and many other problems. What is it used for?

Antioxidant Properties

Licorice is being studied for its effects against oxidation of LDL cholesterol, which is a major component in atherosclerosis. Approximately 300 different phytonutrient compounds found in natural licorice are considered possible antioxidants.

Anti-Viral Properties

Licorice is being tested for its ability to help prevent certain viruses from replicating themselves in body cells. It appears to stimulate the immune system into producing interferon, which is known for its anti-viral effects. It is an effective aid in treating herpes and hepatitis. Promising results are also being reported in tests using licorice to combat SARS, influenza and HIV.

Stomach and Intestinal Problems

Licorice is a natural home remedy for heartburn, gastritis and acid reflux. It helps to promote new cell growth in the lining of the stomach. It also enhances the stomach's self-protecting abilities. Licorice has been used to treat peptic ulcers and aid in healing other types of ulcers.

Throat and Respiratory Problems

Licorice is widely known in the world of alternative medicine as an expectorant and cough suppressant. Colds and flu have been treated with licorice since the days of the Romans. Many over-the-counter cough medicines contain licorice extract because it soothes the mucous membranes.

Other Medicinal Properties

  • * Cleansing the colon
  • * Supporting lung health
  • * Promoting adrenal gland function
  • * Soothing sore throats
  • * Lowering stomach acid levels
  • * Coating the stomach wall
  • * As a laxative
  • * As a diuretic
  • * Stopping flatulence
  • * Relieving rheumatism
  • * Relieving arthritis
  • * Regulating low blood sugar
  • * Treating Addison's disease
  • * Treating symptoms of menopause
  • * Regulating menstruation
  • * Relieving menstrual cramps
  • * Possibly reducing the occurrence of night sweats
  • * Balancing hormones
  • * Healing cold sores and canker sores
The Romans made licorice extract. Chinese herbalists use licorice for treating a wide range of conditions. Its confectionery use originated in England in the 16th century. The roots are used to flavor fruit juices and syrups. They are also used to flavor alcoholic drinks such as Sambuca and Guiness beer.

Is Licorice Safe?

Licorice is not recommended for use by people who suffer from diabetes mellitus, heart disease, hypertension or kidney disease. It is also not recommended for use by women who are pregnant or breast-feeding.

Side Effects

Licorice, although not thought to suppress the immune system like pharmaceutical cortisones, may cause similar side effects in high doses. Some of these include weight gain, fluid retention and high blood pressure.

Description and Cultivation

The licorice plant stands up to five feet tall. It has spikes of lilac-colored flowers that have bean-like pods containing three or four seeds apiece. The root, which is used most frequently, Reaches underground about three feet and branches into networks of rhizomes.

After three to five years, the roots and rhizomes are cleaned, pulped, boiled and then concentrated by evaporation. The root, if kept dry, will keep for an indefinite amount of time. If the licorice is powdered, it should be stored in an airtight container.

Licorice has been used for centuries in conjunction with established medicine, as an alternative herbal medicine, and as an herbal confection in many parts of the world. It is noted for its medicinal value in treating stomach, intestinal and other ailments, including helping to stimulate the immune system. Studies are ongoing to discover more potential uses for this naturally sweet herb.



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GTF Chromium
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Date: April 23, 2008 11:21 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GTF Chromium

Chromium is a trace element in your body, meaning that it is present only in very small quantities, yet like many trace elements it is extremely important to your health. Most people associate chromium with the shiny finish on car fenders, but it is more than that.

Chromium oxide was discovered as being a part of crocoite, better known as red lead, which is actually lead chromate, sometimes containing some molybdate and perhaps vanadium. Although it was discovered in the middle of the 18th century, it was not until 1797 that chemist Louis-Nicholas Vauquelin discovered it for what it was. He synthesized it in his laboratory in 1798, which is the ultimate proof of the identity and chemical structure of any substance.

It was eventually named chromium, after the Greek ‘chroma’ meaning color, because its compounds are highly colored, normally yellow, red and green, and it is chromium that gives emerald its green color. It is also found in low concentrations in the human body, but too low, thankfully, to color your body red, green or yellow! Perhaps Martians contain a lot of chromium!

The first indication of the potential benefits of chromium to health was when a pork kidney extract called the Glucose Tolerance Factor was discovered in 1957 to enable rats to improve their use of insulin in maintaining the effective use of blood sugar in generating energy. The GTF contained chromium, and that was believed to be the effective ingredient.

Diabetes is a condition in which people either do not generate enough insulin or cannot use it properly. Insulin is a hormone biosynthesized in a group of cells known as the islets of Langerhen in the pancreas and is a necessary part of your metabolism. Your metabolism converts carbohydrates and various sugars into glucose, and when the glucose level Reaches a certain concentration in your blood, you stop feeling hungry and the pancreas is stimulated into secreting insulin.

The insulin allows the cells to admit sugar and the mitochondria within them to convert the glucose to energy. Your body likes the blood glucose level to be maintained at between 70 and 110 mg/dl. If it falls below 70, then you will be suffering from hypoglycemia, but you can be above 110 if you have recently eaten. If your blood glucose is being measured it must be at least four hours after your last meal, which is why you are asked to fast first. The absolute maximum is 180 mg/dl, above which you are in trouble and suffering hyperglycemia.

If your pancreas cannot produce any insulin you are regarded as having Type 1 diabetes, and if it produces too little or your body cannot use it effectively, it is Type 2 diabetes. It is believed today that chromium is one of the factors involved in allowing the cells to absorb glucose, and that without it the mitochondria are unable to convert your blood glucose into energy.

Although up to 90% of Americans are thought to have a low chromium content, few are believed to be deficient and there is a big difference between the two. However, pregnant women and the elderly are particularly prone to a deficiency, as are those that consume too many sugary foods. A deficiency in chromium not only leads to an excess of blood sugar however, but also of cholesterol and triglycerides. This can in turn lead to atherosclerosis, heart disease and strokes.

Although the role of chromium in the control of blood sugar levels was discovered in the 1950s, it was not until the 1970s that it was proven. As with many such proofs it came about accidentally, through what was known as Total Parenteral Nutrition (TPN). This provided intravenous nourishment to patients who were unable to eat, and contained a mixture of the nutrients believed to be essential to life.

However, the mixture was based on current knowledge, and it was found that some patients developed the symptoms of hyperglycemia, or high blood sugar levels. This was what would have been expected of untreated diabetics, but none were diagnosed with the condition so the cause was a mystery. The physicians responsible for the treatment had no option but to administer insulin, even though there appeared to be no deficiency in the patients.

If you are with us so far, then you will realize that the insulin would not have had the expected result. That is because the condition is not caused by too much sugar or carbohydrate in the diet, and also not caused by a deficiency of insulin. However, due to the known role of chromium in the action of insulin, it was then thought that TNP solution would be improved by adding chromium. When chromium was added in small quantities of under 50 micrograms (5 hundredths of a gram) the patients’ condition improved to normal, and the effect of chromium on blood sugar levels was finally proven.

So how does chromium achieve this? In fact the biochemistry is complex, and dietary chromium works in a different way to the chromium picolinate that is the most popular form of chromium supplement. However, in a nutshell, what appears to happen is that its effect on human tissue may be through an increase in the activation of Akt Phosphorylation, which is a protein within the body cells that enables the easy absorption of glucose into the cells.

In addition to that, cell membranes contain insulin receptor sites that respond to biochemical signals from messengers such as hormones and nutrients, and it is believed that chromium might be involved in promoting the binding of insulin to these sites. Alternatively, it is possible that it may promote the reactions that occur after the insulin has bound to the receptor site, an occurrence that is referred to as a post-receptor event.

Whether chromium is involved in a post-receptor event or in binding the insulin top the receptor sites, there is no doubting the importance of the element to the overall insulin-glucose-energy metabolism, and that the trace element chromium is indeed important in helping your body cells to absorb glucose.



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What is Hoodia?
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Date: April 08, 2008 08:52 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What is Hoodia?

1. What is Hoodia? Despite its similar appearance, the cactus-like hoodia is characterized as a succulent plant, which is a member of the milkweed family. Though there are about 20 species within the family, the active ingredient of hoodia is found only in the gordonii variety native to South Africa's vast Kalahari Desert

2. What assurances can be made that Source Naturals Hoodia Extract is authentic? Experts in succulent horticulture have helped ensure that the raw material Source Naturals uses to make Hoodia Extract is gathered from authentic Hoodia gordonii sources. From there, our supplier has an independent laboratory test the raw material, which is then issued with a certificate of analysis qualifying it as true Hoodia gordonii.

Once Source Naturals receives the certified Hoodia gordonii from our suppliers, we hold it to our own high standards and Total Quality Assurance. By putting it through stringent testing procedures in our quality control lab, we've carefully scrutinized the material. Before it ever Reaches the hand of consumers, our high-quality hoodia is put through High Performance Thin Layer Chromatographic (HPTLC) analysis for authenticity, and microbiological screening for contamination, as well as other rigorous laboratory protocols.

3. Could you explain the 20:1 ratio? 20:1 refers to the "wet to dry" ratio of the whole plant to concentrated powder. Hoodia gordonii contains an abundance of excess moisture that needs to be removed in order to make an effective, concentrated powder. The process by which that moisture is removed to yield the powder is an extraction. Basically, 20 pounds of whole plant is concentrated to one pound of the high-quality powder used to make our product.

What this means is, we've made a supplement with 20 times more functional hoodia than had we ground the plant up water and all. When you buy Source Naturals Hoodia Extract, you're getting all of the usable plant parts of the Hoodia gordonii times 20, because we've packed a greater amount of the quintessential hoodia ingredients into a powerful, concentrated powder.

4. Is a 20:1 concentrated extract more effective than 1:1 hoodia powder? We at Source Naturals certainly believe so. Unfortunately, the hoodia landscape has been unnecessarily clouded recently thanks to the misinformation circulating about concentrated extracts and so-called "100%" (1:1) hoodia powder. Most of the information is highly subjective, with no studies whatsoever to support claims that so-called "pure" powder is more efficacious than 20:1 concentrated extracts.

The common selling point for those propagating a 1:1 hoodia product is the notion that "more is better" - which, when you think about it, actually benefits a 20:1 concentrated extract. Because the logic behind using the 20:1 concentrated extract is that, in supplementation, it's not practical to ingest as much of the whole plant parts of hoodia as the San did to get the potential benefits of the plant. In using the concentrated 20:1 ratio, we're able to pack 20 times the amount of usable hoodia into our Hoodia Extract. How much more could you need?

5. Where was the hoodia in Hoodia Extract grown? On an approved farm in Northern Cape, South Africa.

6. Who is our supplier? Due to obvious business considerations, we don't want to specifically name our supplier and alert competitors to our source. However you can be assured that we receive our Hoodia gordonii from one of the industry's top suppliers, who was among the first and only importers of hoodia licensed to sell and import the plant into the United States.

7. I've heard there are sustainability issues with the plant. Is it endangered? It is true that the resources for Hoodia gordonii are limited due to early irresponsibility on those seeking to exploit the plant's benefits. However, Source Naturals Hoodia Extract has been produced with environmental sustainability in mind. We've made absolutely sure that only materials safely cultivated from the stems of seedlings grown on approved farms in South Africa have been used in making Hoodia Extract, not material indiscriminately picked in the wild.

8. How should it be used? Take one to two tablets or capsules with an 8 ounce glass of water about an hour before eating a meal.

9. Why does the label warning recommend consulting your health care professional before using this product if you are taking any prescription medication? This is a standard warning included on most Source Naturals product labels because generally it's a good idea to double check with your physician if you're taking prescription medication to make sure there aren't any special precautions you need to take while on the medication.

10. Does it contain caffeine? No. There is no caffeine in Hoodia gordonii, and Source Naturals Hoodia Extract does not contain any added caffeine.

11. Are there any side-effects? There are no known negative side-effects to taking hoodia products.

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Eighty Seven Percent of All Type 2 Diabetes Can Be Prevented Naturally
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Date: January 24, 2008 05:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Eighty Seven Percent of All Type 2 Diabetes Can Be Prevented Naturally

It is a fact that almost 90% of Type 2 diabetes can be prevented by attention to diet and the use of specific supplements. However, before having a look at these possibilities, we shall first have a look at what type 2 diabetes is so that the means of prevention can be better understood.

Diabetes is a condition, not a disease. It cannot be passed from one person to another, and there is evidence that it is hereditary since it tends to run in families. In the past it tended to develop later in life, although the modern lifestyle appears to have made it more common now in children and young adults.

Diabetes occurs when the level of glucose in your blood becomes higher than it should be. The reason for this is twofold: either the body produces no or insufficient insulin or it cannot use the insulin that is produced. Sugars and other carbohydrates are metabolized to glucose that is the body’s source of energy. The parts of your body that do this are the mitochondria that are contained within your body cells, and the hormone insulin is essential in allowing this to happen.

When the concentration of glucose in your blood Reaches a certain level, the pancreas secretes insulin into your blood. The insulin is synthesized in special cells called the islets of Langerhans, after the person who discovered them. Also produced is glucagon which is also secreted into your bloodstream, and the glucagons and the insulin work together to ensure that your blood glucose levels remain stable (when everything is working correctly).

Glucagon is secreted when your glucose levels are low, and its presence in the bloodstream stimulates the conversion of the emergency energy store in the liver (glycogen) to glucose in order to maintain this stability. Insulin, on the other hand, is released after you have consumed a meal, and your glucose levels are high. What insulin does is to stimulate the cells of your body to convert glucose to energy and either use it immediately, or store it as glycogen for use later. By means of these two substances, the level of glucose in your blood is maintained at safe levels – normally.

If something happens to the supply of insulin, then the blood sugar level will continue to rise until the bloodstreams contains too much glucose, a condition known as hyperglycemia. The symptoms are excessive thirst, a frequent desire to urinate, fungal infections or thrush around the genital area (due to yeasts and sugar fermentation), and various others such as mood swings, cramps, dizziness and a feeling of tiredness and weakness.

Type 1 diabetes occurs when the body produces no insulin, and the only possible treatment is continual insulin injections. Type 2 diabetes is defined in two ways. Either your body does not make enough insulin for your needs, or the cells in your body cannot use the insulin produced properly. It is Type 2 diabetes we are concerned with here, and that we shall be exclusively discussing. With Type 2 diabetes, insulin shots can be provided, but there are other factors that can also help to resolve the problem.

Before discussion treatment or prevention, you should be aware of the complications that Type 2 diabetes can lead to. Hyperglycemia is not common with this type of diabetes, but it can develop. If it does then it can be a life-threatening condition needing a rapid injection of insulin into the bloodstream Symptoms prior to the critical stage are drowsiness and dehydration, although as stated, this is more commonly associated with Type 1 diabetes where regular insulin injections is the normal treatment.

Longer term complications of Type 2 include kidney damage, hardening of the arteries, eye problems, impotence and problems with your circulation. Nerve damage can also occur, and it is important that you avoid these by changing your diet and lifestyle. These problems occur if you have had high blood glucose levels over a long period of time, and you therefore have time to take the steps necessary to avoid them if you start now. The same steps will also help you to avoid the condition from occurring. So what are these steps you should take?

The first is to look carefully at your diet. A healthy balanced diet is essential if you are to beat your condition naturally and avoid the potential longer term side effects. Diabetes is associated with the overweight and obese. That is not to say that only these people become diabetic, but the majority are. Most people with Type 2 diabetes are overweight, and although around 65% of Americans are overweight or obese, a considerably higher proportion of those with Type 2 diabetes are overweight.

The first and obvious action to take to avoid this type of diabetes would therefore be to lose weight, and adopt a healthy diet that is free from junk food, trans fats and alcohol, all of which contribute to obesity. The next is to look to your blood pressure and keep it normal, and also to keep your low density lipoproteins (LDL) low. These affect the propensity for your blood cholesterol to deposit in your arteries, especially if they are oxidized by free radicals. A good antioxidant content is therefore recommended in your diet. Although blood pressure and high LDL levels do not directly contribute to diabetes, they are risk factors that could increase the risk to your health if you are diabetic.

You should eat a diet that is high in whole grains and fiber, and eat lean meats and fish rather than fatty foods. Stick to complex carbohydrates that metabolize to glucose slowly and steadily, rather than starchy foods that produce a sudden sugar rush that will give you problems and could promote Type 2 diabetes in those that are prone to it.

Specific supplements that you could take include chromium picolinate that can not only be used to treat existing diabetes patients but also to reduce your chances of developing Type 2 diabetes. Studies involving the use of chromium picolinate on patients with this type of diabetes have been very positive, resulting in reduced blood sugar, lipid and insulin levels. The optimum dosage is around 500 micrograms twice daily. Such treatment has been shown to both prevent and reverse Type 2 diabetes.

Magnesium is another specific supplement that studies have suggested can lower the risk of developing this type of diabetes. Magnesium rich foods have also been found to be effective, and the fact that a magnesium deficiency can lead to diabetes supports the findings that its use can help to prevent it. Green leafy vegetables such as spinach, and beans nuts and seeds are generally rich in magnesium.

Vitamin D can also help protect against the development of diabetes. Although the research is relatively new, it has been established that the cells that produce insulin are affected by a lack of vitamin D in the blood, and low levels of vitamin D can also led to insulin resistance. If you spend more time out in the sun, you should have less chance of contracting Type 2 diabetes, although you could also take a supplement.

Although Type 2 diabetes is not as serious as Type 1, no form of diabetes is desirable to have, and ultimately both types can be extremely serious. You should do what you can to avoid diabetes, and Type 2 is easier to avoid then Type 1. Diet, weight and supplementation as described above will all help to avoid contracting this condition, so follow the advice, especially if you are overweight and have a sweet tooth.

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The Healing Power Of Borage Oil’s GLA
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Date: November 13, 2007 10:22 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Healing Power Of Borage Oil’s GLA

Borage is otherwise called the starflower, and the borage oil extracted from its seeds is very rich in GLA, gamma linolenic acid, a polyunsaturated fatty acid also obtainable from evening primrose oil. Borage, however, is richer in GLA, and is therefore a more economical source that the evening primrose.

A shrub, frequently seen in gardens, borage has historically been used as a salad food, and also in soups, and borage honey is prized in many quarters. Now, however, its main use is for the GLA extracted from the seed, which provides a higher yield of GLA than any other source. Borage seed oil contains up to 25% GLA, compared to the 17% from blackcurrant oil and 9% from evening primrose oil.

The importance of GLA to the body’s biochemistry is inestimable, and cannot be overstated. It is not so much the GLA that is so important, but the prostaglandin to which it is converted in the body. Prostaglandin E1 is a hormone-like substance that plays a part in many of the biochemical and metabolic processes of the body. Examples include the control of the immune system and inflammatory response, some kidney functions, and the tone of the arterial muscles, so important in the health of the cardiovascular system.

A good fatty acid metabolism benefits some very important aspects of our health such as maintaining a good blood pressure, low cholesterol levels, preventing inflammatory and immune system conditions such as arthritis, allergies and some skin diseases such as eczema and psoriasis, and also improving the strength of the keratin-dependent tissues such as our nails and hair.

A deficiency in essential fatty acids also seems to stimulate the overproduction of a hormone in women called prolactin that can lead to the severe mood changes commonly referred to as pre-menstrual syndrome, or PMS. GLA appears to have a beneficial effect in the treatment of PMS, and some other conditions such as breast discomfort.

Gamma linolenic acid is created in the body from linoleic acid, of which there is a plentiful supply in margarine, vegetable oils and many processed foods, but there is a problem. Fatty acid molecules come in different isomeric forms, in which although the chemical is the same, the geometry or ‘stereochemistry’ is different. The healthy form is the ‘cis’ formation, and the other is the ‘trans’ stereoisomer. The trans fatty acids are formed by hydrogenation of oils to make them semi-solid, and more suitable for spreading. This hydrogenation process causes an irreversible change in the geometry of the fatty acid that can block the conversion of linoleic acid to GLA in the body.

Hence, although most of the western population has more than sufficient linoleic acid in their diets, many who eat an excess of trans fats have a deficiency of GLA. Some B vitamin deficiencies and a deficiency in certain minerals exacerbate this situation, and a gamma linolenic acid supplement is needed. Additional to this, the enzyme responsible for the conversion, delta-6-desaturase (D6D) can be affected by many modern environmental factors such as smoking, stress, alcohol, excessive animal fat consumption and even excessive linoleic acid consumption. The solution to all of this is GLA which does not require any enzymes for its creation, and supplemental GLA from any source can immediately take part in the biochemical pathway to the creation of the prostaglandin eicosanoids.

GLA provides the means and the resultant prostaglandins carry out the job of regulating the hormonal activity within human biochemistry. Prostaglandins help to regulate the function of many of the cells in the body, such as the smooth muscle cells of the arteries and veins that cause constriction or dilation, and on the stickiness of blood platelets causing their aggregation. They are important in the regulation of such functions as blood clotting, fluid balance and the production and balance of hormones. The anti-inflammatory properties of prostaglandin E1 are very important to the way that the body reacts to bReaches by foreign invaders, and it is also thought to act to thin the blood and cause dilation of blood vessels, hence its effect in lowering the blood pressure.

So what does this mean to you, apart from the effects of the fatty acid on PMS? Borage oil can be used to treat a large number of different symptoms associated with a shortage of GLA and prostaglandin E1, and here are a few of the conditions for which a GLA supplement has been found beneficial.

A deficiency in GLA and other essential fatty acids can lead to loss of bone mass and subsequent osteoporosis and it is thought that fatty acids help the absorption of calcium by the digestive system, and to increase its deposit in bones. It can be used to increase bone mass and density and therefore strengthen the bones of those affected by osteoporosis. This is partially due to the hormone regulatory effect GLA has on the body.

Allergies appear to be very personal responses by the immune system to specific substances, and while borage oil has proved beneficial in a few allergies, and prostaglandins are known to regulate the activity of the immune response, the effectiveness of GLA treatment for allergies has been mixed. There is evidence that it can affect some cases, but not most.

GLA from borage oil can reduce the swelling and pain of rheumatoid arthritis, and helps to ease morning stiffness. Its effectiveness seems mixed, and you should try it for two or three months to determine if it helps you personally. Be careful, however, since some believe that it might react with some of the non-steroidal anti-inflammatory drugs (NSAID) used to treat this condition. Ibuprofen is one, so check with your physician before trying it.

If you suffer from high blood pressure, borage oil used in conjunction with Omega-3 fish oils might lower it, though more research is needed. There is a belief that the GLA is not the active agent here since Omega-3 oils are known to help to reduce hypertension, though the effect of prostaglandins on the factors that can reduce blood pressure is inarguable.

The healing power of borage oil should not be underestimated, and it has been used for centuries in folk medicine to treat many conditions, especially those that science has found to be caused by the immune system and the inflammatory response. Borage oil can be found at any Health Food Store.



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Omega-3 Relieves Depression in Some Individuals
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Date: November 02, 2007 03:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Omega-3 Relieves Depression in Some Individuals

Omega-3 oils contain fatty acids that are known as essential fatty acids because they cannot be manufactured in your body but have to be taken in your diet. They provide many benefits to your body, and are also believed to relieve depression in some individuals. First, however, an overview of the more conventional benefits of omega-3 oils.

Obtainable in your diet from oily fish such as mackerel, herring, salmon and the like, omega-3 fatty acids play an important part in your normal growth and development, and are also crucial to normal brain function. They can reduce inflammation and protect you from heart disease and some cancers. Studies have shown the fatty acids to be particularly concentrated in the brain and to be important for cognitive processes and memory.

The effects of omega 3 fish oils on the brain are well documented, and they are known to be effective treatments in some cases of bipolar and schizophrenia. It is believed that they could also be used as a treatment in other disorders such as attention deficit disorder and dyslexia, but there is as yet no evidence that this is the case.

Omega-3 fatty acids reduce the so-called ‘bad’ low density lipoprotein (LDL) cholesterol levels and increase the high density lipoproteins (HDL) that take the cholesterol back to the liver for destruction. The end result is a reduction in the cholesterol content of the blood that can be deposited on the artery walls and promote atherosclerosis. Diets high in omega-3 fatty acids appear to lower blood pressure in those suffering from hypertension, and so reduce their chances of heart attacks and strokes.

Omega 3 oils are also natural inflammatories, and help prevent conditions involving inflammation such as arthritis, asthma and menstrual cramps. They appear to help the immune system to fight these conditions and reduce the inflammation and its causes.

They are also important in the formation of prostaglandins that are responsible for the regulation of important functions such as blood pressure, blood clotting and immune response. They are hormone-like substances and also control the synthesis in the body of other hormones. If the balance of fatty acids in the diet is not right, then the subsequent imbalance in prostaglandin and hormone production can lead to disease.

It is in its effect on depression and mood, however, that has surprised many in the medical, profession. Ethyl-eicosapentaenoate, known as ethyl EPA, is a constituent of omega-3 fish oil and many studies have demonstrated that this substance helps cases of depression and related disorders. However, are people justified in turning to ethyl EPA to help them be cured of this condition?

In one study involving 20 people, six out of ten people given the supplement displayed significantly reduced symptoms of depression after four weeks. The effects were noticed as early as two weeks and many of the depression symptoms, such as worthlessness and insomnia, had improved after three weeks. This conformed with the results of many other studies that have been carried out world wide. In Scotland, a number of patients were studied who had failed to respond to traditional antidepressant drugs. Of the seventy patients involved in the trial, all of the patients who were treated with EPA displayed significant improvements in all the symptoms of their depression after four weeks whereas those with the placebo showed no improvement.

Of the two main components of omega-3 fish oil, EPA and docosahexaenoic acid (DHA), only the EPA has this property, and the EPA works best alone when the DHA has been extracted. Studies and tests have indicated that the DHA appears to be important for the brain’s structure, but the EPA for its function, hence the reason for the ineffectiveness of the former in relieving depression which is a function of the brain rather connected to its structure. In fact, depressed people have been found to be deficient in EPA in comparison to those not suffering from the condition. The original idea for this originated with the late Dr. Horribin who was pioneer in researching the effects of lipids on the biochemistry of the brain as far back as the 1970s. Since then the world-wide research has confirmed his theory. However, the reason why this theory works in practice is not yet understood. It has been established that a diet rich in trans fats can unfavorably affect the hormones in the brain that stabilize mood, possibly due to the fats slowing down the system of messaging within the brain. This kind of effect can cause depression.

This is likely due to the slowing down of the messages passing between the synapses. Brain cells communicate by means of chemicals that cross the synapses, or small gaps between the individual cells. They are not directly connected like normal electrical circuits. It has been theorized that the EPA speeds up the passage of these messages between neurotransmitters and neuroreceptors. Other theories have also been promoted, such as that the EPA has properties of its own that cure depression by another route altogether.

A possible clue could be in the findings of one study on a man aged 21 years old whose brain was scanned before and after EPA treatment. The result showed in increase in the mass of brain cells after the treatment. This was contrary to the belief that brain cells could neither be generated nor grown once a person Reaches maturity.

An individual suffering depression who would like to treat themselves with EPA would have to buy a lot of oily fish since high doses are needed for this level of therapy. However, it is found in high concentrations in a few supplements available on the market, and when choosing you must use the highest grade of EPA you can get, with as low a DHA content as you can find.

There is little doubt now; however, that the EPA content of omega-3 relieves depression in some individuals, although more work is needed to prove without doubt that it is effective with all forms of depression.



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Artemisinin For Better Health And Wellness
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Date: October 25, 2007 02:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Artemisinin For Better Health And Wellness

Artemisinin, also called Ching-hao-su is a herbal medicine extracted from the sweet wormwood herb, also known as the Artemisia annua. Asians have been using the leaf for centuries to cure simple ailments such as colds and parasitic infections, but it has recently become big business for its effect on malaria.

Sweet wormwood is predominantly a Chinese herb, used for over a thousand years for treatment of a large variety of conditions including malaria. It has also been used to treat wound and skin diseases, and has been recorded as far back as 200 BC as a component of Chinese prescriptions for specific illnesses.

Although the origins of sweet wormwood are in Asia however, it is now grown throughout the temperate regions of the world, and Reaches its best in midsummer. Although best known today for its use in treating malaria, its medical uses include treating bronchitis, fevers and general feelings of malaise. It is primarily grown now for the supplement industry and as a non-prescriptive natural cure for malaria. It is a common and favorite herb for Chinese herbalists and sold both in the herbal form and as the extracted artemisinin.

Although there is a wide variation in the artemisinin content of sweet wormwood according to where it is grown, and under different agricultural conditions, it is the main active ingredient. Chemically, it is a sesquiterpene lactone containing an endoperoxide bridge that will be discussed later.

In order to attain the optimum yield of active artemisinin, the plant has to be grown in the right site for cultivation and fed with the correct fertilizers, the proper strain of the herb must be selected and the method of extracting the active chemicals is also critical. These are secrets that have been used for centuries by the Chinese herbalists who are masters of their craft and are now known to the west and being applied to scientific production of the extract.

There are benefits of artemisinin other than its effect on malaria, but that is the best known of its uses, so let’s have a look at that first. The herb has been used for a long time to treat parasitic infections, mainly flukes and worms that place great strains on the body having not only to feed these unwanted creatures, but also to excrete their waste and by-products. Malaria is caused by such a parasite, any one of four types in fact, and artemisinin appears to be just as effective on them.

The chemical contains what is known as an endoperoxide bridge that reacts with iron. The product of this reaction is a free radical, normally unwelcome in the body. However, malaria parasites contain high levels of iron, and the artemisinin reacts with that iron, forming free radicals that then go on to kill off the parasite. The free radicals that we take supplements to destroy, actually work for us in the destruction of the parasite that cause malaria. There is a silver lining in every cloud!

The reason that the medical world is so excited with this material is that malaria is second only to tuberculosis in its impact on world health. The problem is that the parasites that cause it have become largely resistant to the normal cures. They are not, however, resistant to the endoperoxide chemistry contained by artemisinin. It is now the major hope of world leaders in the fight to stop the inexorable increase in deaths due to malaria.

Now for the other applications. Another major use of the chemical is in the fight against cancer. Those cancers that involve iron rich cells can be disrupted by artemisinin by the same mechanism that kills off malaria bacteria. It is not only parasites that are susceptible to free radical action, but also human cells, and if these can be selectively destroyed, then it is a step forward towards a cure for cancer. Such a cure does not yet exist, but mechanisms such as the endoperoxide bridge provide a means of controlling at least some cancers, the best results being obtained with leukemia and colon cancer. That is not to say, however, that cures for these cancers are currently available since tests are still under way. However, it would do no harm to use sweet wormwood or the artemisinin extract as a supplement.

Cancer cells tend to accumulate iron because it is needed in the cell division process that cancer takes advantage of. However, if cancer cells could be persuaded to accumulate more surface iron, or were artificially exposed to it, then perhaps the endoperoxide mechanism would be more effective. Studies on this mechanism of controlling cancer are currently under way.

At a more mundane level, if you suffer from intestinal parasites, then one or two milligrams each day should see them off. It has also been effectively used to deal with colds, coughs and other general conditions, but most effectively against those that cause fever of one kind or another. It has been used in Chinese medicine as a form of ‘cure-all’ to be used when specific remedies failed. Its greatest current uses are, however, in cancer and especially malarial treatments.

You have to be careful with artemisinin since it can be toxic if taken in the wrong form. The least toxic, and most active, is the water soluble form known as artesunate. However, it lasts the least time in the body and has to get to work quickly. The oil soluble form, artemether, is the most toxic, but can cross from the blood to the brain. However, the parent form, artemisinin is the very safe itself, and can also cross the blood-brain barrier and while some tend to use a combination of the three, others prefer just the parent form.

If you take too high a dose you can suffer neurotoxicity which makes you wobble when you walk, and makes you impervious to certain levels of pain. However, such doses are next to impossible accidentally, and there have been very few reports of adverse effects in humans. It should not be used for at least a month after you have had radiation therapy because that tends to release iron that can be attacked to form free radicals. The recommended dose is 200 – 100 mg daily though the doses should be spread throughout the day. It should also never be taken within 2 hours of any other antioxidant such as vitamins A, C and E. Otherwise artemisinin can be safely used for better health and wellness in the way that the Chinese have been using it for centuries. Artemisinin is available at your local or internet vitamin store.

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Reduce Your Cholesterol With Natural Vitamins
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Date: July 12, 2007 08:58 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Reduce Your Cholesterol With Natural Vitamins

 

Thanks to the excellent efforts of health education organizations like the American Heart Association, we’ve learned a lot about cholesterol and how it affects our health.

We know: high cholesterol levels increase our risk for heart attacks and strokes: lowering our cholesterol levels will reduce this risk and keep our hearts and blood vessels healthy; and that diet, weight loss, and exercise will all help us in our quest to lower our cholesterol levels. We also know at times, despite these good efforts, some people’s cholesterol levels are still too high.

Prescription drugs to lower cholesterol are now available and they are heavily advertised by the pharmaceutical companies that make them. What the commercials neglect to say is these medications, collectively called statin drugs, have some serious side effects. Statin drugs can cause elevations in liver enzymes, an indication of liver irritation. They are associated with myopathy, a painful disorder of muscle inflammation and muscle degeneration. Ironically, statin drugs significantly reduce CoQ10 levels in the body, a deficit that can lead to heart disease.

Statin drugs have also been linked to a rare and at times, fatal condition called rhabdomyolysis. Because of this alarming link, the makers of cerivistatin, a popular stain drug, recalled this medication from the market on August 8, 2001. The Food and Drug Administration a greed with the recall and supported the decision.

Thankfully, there is a safe solution to the dangers of high cholesterol levels. A natural dietary supplement is now available that can lower cholesterol very effectively without any harmful side effects. Backed by many years of scientific research and clinical study, pantethine and plant sterols, also known as phytosterols, are nature’s answer to dangerous prescription cholesterol lowering medications.

To understand how pantethine and plant sterols work to lower cholesterol levels, we need to first review what we know about cholesterol and heart disease.

 

Q. What exactly is cholesterol?

A. Cholesterol is a soft, waxy, fat-like substance found in every cell of the body. We need cholesterol to help digest fats, strengthen cell membranes, insulate nerves, and make hormones. Cholesterol is made primarily in the liver but also by cells lining the small intestine and by individual cells in the body. While our body makes all of the cholesterol we actually need (about 1,000 milligrams a day), we also get additional cholesterol from foods we eat.

The highest source of cholesterol are egg yolks and organ meats such a liver and kidney. No plant-derived food contains cholesterol, not even peanut butter or avocado, even though these foods are high in fat. However, all foods from animal sources such as meats, poultry, fish, eggs, and dairy products contain cholesterol.

 

Q. How does cholesterol cause heart disease?

A. Although cholesterol serves many important functions in the body, too much cholesterol in the bloodstream can be dangerous. When blood cholesterol Reaches high levels, it builds up on artery walls, increasing the risk of blood clots, heart attack, and stroke.

The heart is a muscle, and like all muscles, needs a constant supply of oxygen and nutrients. The bloodstream transports these nutrients to the heart through the coronary arteries. If the coronary arteries became narrowed or clogged by cholesterol and fat deposits (artherosclerosis) and cannot supply enough blood to the heart, the result is coronary heart disease (CHD). IF not enough oxygen-carrying blood Reaches the heart muscle, a sharp, sudden chest pain (angina) may occur. If the blood supply to a portion of the heart is completely cut off by total blockage of a coronary artery, the result is a heart attack. This is most often caused from a blood clot forming on top of an already narrowed artery.

 

Q. What is LDL and HDL cholesterol?

A. Cholesterol and other fats can’t dissolve in the blood and, therefore, can’t travel on their own. They have to be transported to and from the cells by special carriers called lipoproteins. The two major lipoproteins are low density lipoproteins (LDL) and high density lipoproteins (HDL). LDL is most often referred to as the “bad” cholesterol whereas HDL is known as the “good” cholesterol.

LDLs carry cholesterol throughout the body to the cells. LDLs cause artherosclerosis by clogging up our arteries with the continual buildup of fat. HDL, on the other hand, prevents this fat buildup within arterial walls, by carrying it away from the arteries, to the liver where it is eventually processed and eliminated.

 

Q. What are triglycerides?

A. Triglycerides are fats used as fuel by the body and as an energy source for metabolism. Triglyceride levels fluctuate easily, changing after every meal. Increased levels are almost always a sign of too much carbohydrate and sugar intake. Triglycerides in high amounts make the blood more sluggish and less capable of transporting oxygen, particularly through the small blood vessels. High triglycerides, along with high LDL “bad” cholesterol, are considered strong and independent risk factors for cardiovascular disease, leading to a heart attack or stroke.

There are several medications physicians can prescribe for people with elevated triglyceride levels. Some of the most effective (as well as the most harmful) are the statins. The powerful, all-natural combination of pantethine and plant sterols can safely and, just as effectively, lower both triglycerides and LDL “bad” cholesterol and increase HDL “good” cholesterol.

 

Q. What is pantethine and how does it lower cholesterol?

A. Pantethine, a form of pantothenic acid (also known as vitamin B5) is found in foods such as liver, salmon, and yeast. Pantethine lowers cholesterol by blocking its production.

Cholesterol synthesis, or the production of cholesterol in the human body, is an incredibly complex process. It involves many biochemical reactions and enzymes activity requiring several steps.

Studies have shown that pantethine inhibits several of these enzymes and coenzymes. It blocks the activity of one coenzyme involved in cholesterol synthesis, HMG-CoA, by about 50%. This results in significantly lower cholesterol production. But, that’s not all. To compensate for the lowered cholesterol production, the liver pulls LDL out of the bloodstream. The end results? Studies have shown that on average, pantethine can lower total cholesterol levels by 16%, LDL cholesterol levels by 14%, serum triglycerides by 38%, and can raise HDL cholesterol by 10%.

 

Q. What are plant sterols and how do they lower cholesterol levels?

A. Plant sterols are the fats of plants. They are found in nuts, vegetable oils, corn, and rice. Plant sterols are structurally similar to cholesterol and are able to act as a stand-in for cholesterol and block its absorption.

The liver receives about 800 mg of cholesterol every day from intestinal absorption. Cholesterol is absorbed from the intestines through receptor sites – special channels that are shaped exactly like cholesterol molecules. The cholesterol enters these channels and is then absorbed into the bloodstream. Because plant sterols look like cholesterol, they fit perfectly into these channels. The cholesterol, being blocked from absorption, remains in our intestines where it is eventually excreted.

If we eat enough plant sterols, the amount of cholesterol transported from the intestinal tract to the liver is greatly reduced. And, just like pantethine’s effect on the liver, this cholesterol reduction causes the liver to pull LDL cholesterol out of the blood, reducing both total and LDL cholesterol levels.

 

Q. Can’t we get the benefit of plant sterols and pantethine just by eating those foods that contain them?

A. These amounts of plant sterol and pantethine found in food just aren’t enough to have much of an effect on our health. In order to lower cholesterol levels, we need to take a concentrated combination of pantethine and plant sterols in just the right ratio.

Plant sterols are bound in fibers in the plants. Even if we ate lots of raw fruits and vegetables, we wouldn’t be getting many of these beneficial plant fats. There are also several forms of plant sterols. Some ratios of these plant sterols are more beneficial than others. On the average, we eat 160 to 360 mg of plant sterols a day.

While pantethine is found in several food sources, it is difficult to get beneficial amounts from our food. There are about 12 mg of pantethine in 3 ounces of brewer’s yeast and 8 mg in an average serving of liver.

 

Q. How much pantethine and plant sterol combination should I take?

A. Many studies have examined the effects of pantethine and plant sterols on cholesterol levels resulting in the determination of the most effective amounts to take of these heart healthy nutrients.

Manufacturers of high quality nutritional supplements offer pantethine combined with plant sterols in the most beneficial ratio as determined by the research. The best results are obtained by taking a combination of 400 mg of plant sterols and 200 mg of pantethine three times a day.

 

Q. Should only people with actual heart disease or those with high cholesterol levels be concerned about cholesterol?

A. No, recent studies have shown that cholesterol lowering in people without heart disease greatly reduces their risk for ever developing CHD, including heart attacks and artherosclerosis. This is true for those with high cholesterol levels and for those with average cholesterol levels.

Most physicians would never consider prescribing statin drugs to people without actual heart disease or high cholesterol levels because of the many health risks of the drugs. But the combination of pantethine and plant sterols can naturally and very effectively help those people with heart disease, high cholesterol levels, high triglyceride levels (or all three!) as well as those of us just wanting added “health insurance” for our hearts.

 

Q. Are pantethine and plant sterols safe?

A. Yes, both pantethine and plant sterols are very safe. Some people may experience some mild stomach upset when they first take pantethine. Taking the combination of pantethine and plant sterols with meals generally solves this problem.

 

Conclusion

Americans have listened, learned, and most importantly, taken to heart the vast and vital information on the need to keep our cholesterol levels under control. The result? More and more Americans are lucky enough to die of old age. The Centers for Disease Control recently released a report stating that the average American life expectancy has reached a new high of 76.9 years, thanks in no small measure to fewer people who are dying from heart disease,

The authors of this report stated that we could push our life expectancy even higher. We can attain healthy, old age by eating right, exercising regularly, and taking other simple steps to promote good health and prevent serious illness and heart disease. Taking the all-natural combination of pantethine and plant sterols is one simple, yet powerful step, to keep our hearts and blood vessels healthy for a long, long time.



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Do you experience muscle pain and inflammation?
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Date: April 25, 2007 03:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Do you experience muscle pain and inflammation?

FlexAgility MAX

 

Everyone experiences muscle pain and inflammation due to overuse and exertion. We’ve all had those softball games, weekend camping trips or chore-intensive days when our body lets us know we’ve overdone it.

So, what can you do about it? Well, fortunately, there is a proprietary formula with clinically studied ingredients that provides a natural solution: FlexAgility MAX.

FlexAgility MAX is designed to reduce pain and inflammation due to overuse. Its clinically studied ingredients have been shown to help balance the body’s own inflammatory response. Let’s take a look at FlexAgility MAX and answer a few questions you may have about it.

 

Q. What is inflammation? Why does it happen?

A. Inflammation is actually an essential part of your body’s natural healing process. When some form of physical stress affects the body, the immune system responds by supplying defensive compounds to the stressed site. This is what causes the fluid build-up, pain and redness we typically associate with inflammation. And until the situation is resolved those symptoms will stick around. So, why is that good? Because without these signals – pain and inflammation – we’d probably do even more damage. In a sense, pain and inflammation are very effective stop signs.

The problem is, if our bodies are continuously bombarded by factors that trigger inflammation, these defenders (and their symptoms) are always around. This can mean unnecessary pain and inflammation following overuse and exertion.

 

Q. What does FlexAgility MAX have to do with inflammation?

A. FlexAgility MAX provides triple-action activity against occasional pain and inflammation, with powerful antioxidant free-radical scavengers, the enzyme bromelain, and a natural COX-2 inhibitor.

 

Q. So what is COX-2 and why should I inhibit it?

A. We’ve all been hearing a lot in the news about COX-2 inhibition and may have wondered about its connection to pain and inflammation. Let’s take a look:

Cyclooxygenase is an enzyme that comes in two main types, abbreviated for convenience: COX-1 and COX-2. The COX enzymes regulate compounds involved with inflammation, including prostaglandins. COX-1 is found throughout the body, and maintains the integrity of the stomach lining, circulation and kidneys.

COX-2 on the other hand, cruises along the central nervous system – it’s much more attuned to our brain’s sense of “what hurts.” Primarily activated by inflammatory stress, COX-2 generates prostaglandins – the hormone-like defensive compounds that cause the responses we associate with pain and inflammation due to overuse.

You can understand why so much research has focused on COX-2 inhibition. Decreasing its activity means short-circuiting the “inflammation cascade” that follows occasional overuse.

Because COX-1 is associated with a healthy stomach lining, it is not an enzyme you want to inhibit. Unfortunately, many products don’t know the difference between COX-1 and COX-2 – filing both with one blast.

Fortunately, there are ingredients in FlexAgility MAX that can tell them apart. One of them is IsoOxygene.

IsoOxygene is a patented hops extract shown in scientific studies to significantly inhibit COX-2, while leaving COX-1 alone. And, it is a 20 times more potent COX-2 inhibitor than other tested popular botanic products, including curcumin and grape seed.

 

Q. How do antioxidants support the body during times of inflammation due to overuse?

A. Overall, the body ahs a pretty darn good repair system. However, oxidative stress due to free radical damage can take its toll, especially during times of occasional physical stress. Free radicals and reactive oxygen species can damage cells, because they are hungry, unstable molecules in search of electrons. To find them, they attack other cells. These pillaged cells then become free radicals themselves, setting off a chain reaction of oxidative stress.

Free radicals are formed during the body’s normal functions, and can have benefits, such as neutralizing viruses and bacteria. However, in doing do, they erode the body’s own antioxidant defenses, too. And, free radicals typically become very active during times of inflammation due to overuse or other stressors.

The good news is that the herbal and antioxidant elements in FlexAgility MAX help support the body’s own natural anti-inflammatory defenses.

Take vitamin C, for instance. This extremely well-known antioxidant has been scientifically studied for its beneficial effects on muscle, collagen and connective tissue health. Collagen and connective tissue is what helps hold us together – literally.

And famous antioxidant, green tea, has been well-studied for the benefits of a polyphenol called epigallocatechin-3-gallate, or simply EGCG. In scientific and clinical studies, EGCG from green tea works as an overall antioxidant, scavenging free radicals, and supporting healthy collagen. In fact, one study showed that green tea polyphenols supported collagen health by 50% versus only 16% in controls.

The green tea extract in FlexAgility MAX is especially focused on these beneficial polyphenols. It’s standardized to contain 70% polyphenols – half from EGCG. The green tea acts in concert with elderberry and ginger in the formula to help prevent oxidative stress to the body due to occasional overuse.

Anthocyanins are natural antioxidants found in berries and vegetables. Black elderberry extract, one of the herbal ingredients in FlexAgility MAX, was shown in scientific studies to be more bioavailable – that is, more readily used by the body – than the natural bioflavonoids of other plants. Again, antioxidants help keep the body in optimum health- especially during times of physical stress.

 

Ginger, used for centuries in Ayurvedic medicine, provides strong, natural antioxidant activity. In fact, a recent scientific study found more than 50 separate antioxidants in ginger root.

Of course, there are many components of plants that show strong antioxidant properties. A scientific study comparing flavonoid antioxidant activity and inflammation have shown that rutin was the most effective in reducing the inflammation cascade.

 

Boswellia serrata is a tree found growing in the dry, hilly regions of India. Extracts of boswellia have been used in Ayurvedic practice for centuries. Boswellia also has antioxidant properties that help reduce free radical damage.

Another antioxidant ingredient in FlexAgility MAX, N-acetylcysteine (NAC), even helps the body produce more of its own antioxidants, cysteine and glutathione. In a double-blind, placebo-controlled clinical study, N-acetylcysteine inhibited occasional pain and inflammation due to overuse and attenuated fatigue by 26% compared to controls!

N-acetylcysteine has also been shown in scientific tests to act as an antioxidant, supporting healthy collagen and synovial fluid.

The last ingredient, bromelain, provides the enzymatic pathway used by FlexAgility MAX. Bromelain is a proteolytic enzyme derived from pineapple. Clinical and scientific studies showed benefits from bromelain in reducing pain and inflammation from occasional overuse.

So, there you have it- the triple action of FlexAgility MAX: COX-2 inhibition (and COX-1 sparing), antioxidant benefits, and enzyme support.

 

Q. Is there another product you’d recommend that I use with FlexAgility MAX?

A. One other product I recommend without hesitation is GS-500, a glucosamine sulfate supplement that has been shown to help build and support cartilage. The body’s connective tissue and cartilage include a natural compound called glucosamine. Supplemental glucosamine sulfate is up to 98% absorbable, so more glucosamine Reaches the target structures. It has been clinically studied on its effect in building cartilage.

 

 

About Enzymatic Therapy:

 

Like Chris, Enzymatic Therapy is a trailblazer. Since our founding in 1981, we’ve been leading the industry with innovative natural products. After all, in 1993, Enzymatic Therapy introduced glucosamine sulfate, shown to help build and support cartilage, to the United States. Our product, GS-500, is up to 98% absorbable, so more glucosamine Reaches the target structures.

In the intervening years, Enzymatic Therapy has been at the frontline of innovation and invention. Many revolutionary precuts, including Saventaro, Cell Forte, Heartburn Free, Petadolex Patented Brain Support, Whole Body Cleanse, Earth’s Promise, Hot Plants for Him and Hot Plants for Her have been introduced by Enzymatic Therapy.

One of the newest products, (and the reason you’re reading this) is FlexAgility MAX. FlexAgility MAX works with the body’s own natural anti-inflammatory pathways to relieve pain and reduce inflammation due to occasional overuse. Our proprietary FlexBend of ingredients, combined with antioxidants and the proteolytic enzyme, bromelain, is unique among natural products.



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Learn about Bone Health!
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Date: April 20, 2007 12:43 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Learn about Bone Health!

Bone Health

Approximately 44 million American women and men aged 50 and older have osteoporosis (severe bone loss) or osteopenia (mild bone loss), with women being affected about twice as often as men. At least 1.5 million fractures of the hip, vertebra (back or neck), or wrist occur each year in the United States as a result of osteoporosis, and the annual cost of treating this disorder is nearly $14 billion and rising. Unfortunately, the toll in human suffering and loss of independence is even greater.

In this issue of Ask the Doctor, we will discuss the risk factors for osteoporosis and some key nutrients you can add to your diet that can minimize bone loss and reduce your chances of developing this disease.

Q. What are the risk factors for osteoporosis?

A. Small body frame, underweight, Caucasian or Asian race, a sedentary lifestyle, cigarette smoking, excessive alcohol or caffeine intake, high intake of carbonated beverages (especially colas), and having other family members with osteoporosis all increase personal risk of developing the disease. Certain medical conditions, including diabetes, celiac disease, hyperthyroidism, rheumatoid arthritis, chronic obstructive lung disease, hyperadrenalism, and hyperparathyroidism, are all associated with an increased risk of osteoporosis. Some medications increase the rate at which bone is lost; these include drugs prescribed for the treatment of seizures, drugs used for blood thinning, steroids such as prednisone, aluminum-containing antacids, and loop diuretics (furosemide {Lasix}).

Q. Isn’t bone loss just a normal consequence of aging?

A. Although bone mass normally declines after the age of 35, bone loss severe enough to cause fractures after just minor trauma (such as bump or fall) seems to be a relatively new phenomenon. Osteoporosis was rare in the late 19th century, and it was not until around 1920 that the condition began to attract attention among doctors. Since that time, the percentage of people who develop osteoporosis has continued to increase. For example, the age-adjusted prevalence of osteoporosis in England and Sweden double between 1950 and 1980. In addition, the percentage of elderly people with osteoporosis in some developing countries is lower than that of elderly Americans, despite lower calcium intakes in the developing countries, further suggesting that osteoporosis is a disease of modern civilization.

Q. Can osteoporosis be prevented?

A. Engaging in regular weight bearing exercise, avoiding excessive consumption of alcohol and caffeine, and quitting smoking will slow the rate of bone loss. Eating adequate, but not excessive, amounts of protein also enhances bone health. In addition, a growing body of research has shown that supplementing with various vitamins and minerals may not only help prevent, but in some cases actually reverse, bone loss. At least 15 different nutrients have been found to play a role in bone health.

Q. What type of calcium is best?

A. For most people, calcium salts are absorbed about the same, between 30% and 40% of the administered dose. People who low stomach acid (hypochlorhydria) should not use calcium carbonate, because that form of calcium is absorbed poorly in the absence of stomach acid. Calcium phosphate may be preferable for many older people, because phosphorus is necessary for normal bone formation, the phosphorus intake of older people is often low, and calcium supplements inhibit the absorption of phosphorus.

Also, calcium bound to phosphorus is the form in which calcium in the bone is stored, and it has a much greater bone activity than other forms.

Q. How much vitamin D is needed to promote strong bones?

A. Because vitamin D is produced when the ultraviolet rays from the sun hit skin, people who stay out of the sun, wear sunscreen, or live in a northern latitude (such as Boston or Seattle) where less ultraviolet light Reaches the skin, are at increased risk of vitamin D deficiency. In addition, aging decreases a person’s ability to synthesize vitamin D in the skin. Results from five research trials on vitamin D found that supplementation with 700-800 IU of vitamin D per day decreased the number of hip fractures by 26%, but 400 IU per day was ineffective. In addition to enhancing bone health, vitamin D improves nerve and muscle function in older people, thereby reducing their chances of falling down. Supplementation of elderly women with 800 IU of vitamin D per day has been shown to decrease the number of falls by about 50%.

Q. Is that much vitamin D safe?

A. The Food and Nutrition Board of the Institute of Medicine established a “safe upper limit” of 2,000 IU per day in 1997. More recent research suggests that up to 4,000 IU of vitamin D per day is safe for the average person. However, you likely don’t need nearly this much to address most bone issues.

Q. Why would nutrients besides calcium and vitamin D is important?

A. Bone is living tissue, constantly remodeling itself and engaging in numerous biological functions. Like other tissues in the body, bone has a wide range of nutritional needs. The typical refined and processed American diet has been depleted of many different vitamins and minerals, some of which play a key role in promoting bone health. Not getting enough of one or more of these micronutrients may be and important contributing factor to the modern epidemic of osteoporosis. In addition, supplementing with calcium may cause a loss of magnesium, zinc, silicon, manganese, and phosphorus, unless these nutrients are also provided.

Q. What nutrients besides calcium and vitamin D promote healthy bones?

A. Magnesium, zinc, copper, manganese, vitamin K, boron, strontium, silicon, folic acid, vitamin B6, vitamin B12, phosphorus, and vitamin C have all been shown to play a role in bone health. Following is a brief description of the role that each of these 15 nutrients play in building healthy bones.

Calcium: A component of the mineral crystals that make up bone.

Vitamin D: Enhances calcium absorption, prevents falls by improving nerve and muscle function.

Magnesium: Important for bone mineralization (accumulation of minerals which form bones). Magnesium deficiency is associated with abnormal bone mineral crystals in humans. In an open clinical trial, magnesium supplementation increased bone mineral density by an average 5% after 1-2 years in postmenopausal women.

Copper: Laboratory research has found that copper promotes bone mineralization and decreases bone loss, and that osteoporosis can develop if the diet is deficient in copper. Western diets often contain less copper than the amount recommended by the National Academy of Sciences. In a 2-year double-blind trail, copper supplementation reduced bone loss by 90% in middle-aged women, compared with a placebo.

Zinc: Like magnesium, zinc is important for bone mineralization, and also has been shown to decrease bone loss. Low dietary zinc intake was associated with increased fracture risk in a study of middle-aged and elderly men. The zinc content of the diet is frequently low; a study of elderly low-income people found they were consuming only half the Recommended Dietary Allowance for this mineral.

Manganese: Plays a role in the creation of the connective-tissue components of bone. Manganese deficiency in laboratory tests resulted in low bone mineral density and weak bones. Manganese deficiency may be associated with the development of osteoporosis.

Boron: Supports creation of bone-protecting hormones such as estrogen, testosterone, and DHEA. Boron supplementation prevented bone loss in experimental studies. In human volunteers consuming a low-boron diet, boron supplementation decreased urinary calcium excretion by 25-33%, a change that may indicate reduced bone loss.

Silicon: Plays a role in the synthesis of the connective-tissue components of bone. Silicon deficiency has been associated with bone abnormalities. In an observational study, higher dietary silicon intake correlated with higher bone mineral density. In a clinical trial, administration of an organic silicon compound increased bone mineral density of the femur (or thigh bone) in postmenopausal women.

B vitamins (folic acid, vitamin B6, and vitamin B12): These three B vitamins have been shown to lower blood levels of homocysteine, a breakdown product of the amino acid methionine. An elevated homocysteine concentration is a strong and independent risk factor for fractures in older men and women. Homocysteine levels increase around the time of menopause, which may explain in part why bone loss accelerates at that time. In a 2-year double-blind trial, supplementation of elderly stroke patients with folic acid and vitamin B12 reduced the number of hip fractures by 78%, compared with a placebo.

Strontium: This trace mineral is incorporated into bone and appears to increase bone strength. It also stimulates bone formation and inhibits bone breakdown. Controlled trials have demonstrated that strontium supplementation of postmenopausal women increases bone mineral density and decreases fracture risk.

Vitamin K: Best known for its effect on blood clotting, vitamin K is also required for the creation of osteocalcin, a unique protein found in bone that participates in the mineralization process. The amount of vitamin K needed for optimal bone health appears to be greater than the amount needed to prevent bleeding. Vitamin K levels tend to be low in people with osteoporosis. In randomized clinical trials, supplementation of postmenopausal women with vitamin K prevented bone loss and reduced the incidence of fractures.

Q. Which form of vitamin K is best?

A. Two forms of vitamin K compounds are present in food: vitamin K1 and vitamin K2. Vitamin K1 (also called phylloquinone) is present in leafy green vegetables and some vegetable oils, and vitamin K2 is found in much smaller amounts in meat, cheese, eggs, and natto (fermented soybeans).

To make things a little more complicated, Vitamin K2 itself can occur in more than one form. The two most important to this discussion are menaquinine-4 (MK-4, also called menatetrenone), which is licensed as a prescription drug in Japan, and menaquinone-7 (MK-7), which is extracted from natto.

Research suggests that MK-7 from natto may be an ideal form of vitamin K. The biological activity of MK-7 in laboratory studies was 17 times higher than that of vitamin K1 and 130 times higher than that of MK-4. After oral administration, MK-7 was better absorbed and persisted in the body longer, compared with MK-4 and vitamin K1. Although both have shown ability to prevent osteoporosis in laboratory research, a much lower dosage (600 times lower) of MK-7 is required, compared to MK-4, to obtain beneficial effects.

Thus, MK-7 has greater biological activity, greater bioavailability, and possibly more potent effects on bone, compared with other forms of vitamin K. The potential value of MK-7 for bone health is supported by an observational study from Japan, in which increasing natto consumption was associated with a lower risk of hip fracture. While additional research needs to be done, the available evidence suggests that the best forms of vitamin K for long-term use at physiological doses are MK-7 and vitamin K1.

Q. Why is strontium so important in building strong bones?

A. Strontium is of great interest to bone health researchers and has been studied in very high doses. Surprisingly, lower doses are not only safer for long-term supplementation, but may in fact have a greater impact on bone health than very high doses. Too little, and bone density is impaired; too much and health may be impaired. This is a case where dosing needs to be just right for optimal impact. Therefore, until more is known, it is wise to keep supplemental strontium at less than 6 mg per day.

Q. Can people taking osteoporosis medications also take bone-building nutrients?

A. Because nutrients work by a different mechanism than osteoporosis drugs, nutritional supplements are likely to enhance the beneficial effect of these medications. Calcium or other minerals may interfere with the absorption of biphophonates such as alendronate (Fosamax) or etidronate (Didronel). For that reason, calcium and other minerals should be taken at least two hours before or two hours after these medications. Also, it is always best to discuss the supplements you are using with your healthcare practitioner to create an integrated health plan.

Final thoughts…

Bone health ramifications extend beyond osteoporosis and fractures. Bone health is essential for freedom of movement, safety, comfort, independence and longevity. Weak bones do not heal well – sometimes they never heal at all. Osteoporosis-related fractures rob us of our mobility and consign thousands of Americans to walkers and wheelchairs every year. In fact, 40% of people are unable to walk independently after a hip fracture, and 60% still require assistance a year later. The most terrible consequence of fractures related to osteoporosis is mortality. The impairment of the ability to move around freely can cause pneumonia and skin damage leading to serious infections. It is estimated that suffering a hip fracture increases the risk of dying almost 25%. Making bone health a priority now will allow you to reap health dividends for many years to come.



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Lower Cholesterol Naturally!
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Date: October 06, 2006 09:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Lower Cholesterol Naturally!

Because of organizations like the American Heart Association (AHA), we’ve learned a lot about cholesterol and how it affects our health. Thanks to these educational organizations, we know that high cholesterol levels can increase our risk for heart attacks and strokes and, by lowering these levels, we reduce these risks as well as keep our hearts and blood vessels healthy. We also know that our cholesterol levels can be improved through exercise, diet, and weight loss.

Although we’ve learned a lot through these educational organizations, there are still a few misconceptions about cholesterol. One of these being that not all cholesterol is harmful. There are both “good” and “bad” forms of cholesterol and a good balance between the two is what is needed for a healthy heart. Because so much emphasis is placed on lowering “bad” cholesterol levels, not enough attention is paid to the benefit of raising “good” cholesterol levels (HDL). Research states that raising HDL levels can provide even greater protection against cardiovascular disease than just simply lowering “bad” cholesterol levels. By raising HDL levels by simply 1%, the risk of heart disease can be lowered by 2% in men and 3% in women. Many studies have shown that low HDL cholesterol levels are an independent risk factor in heart disease. This is extremely important because we’ve learned that despite efforts to change a person’s diet and exercise habits, some people’s cholesterol levels are still unhealthy.

Prescription drugs to lower cholesterol are now available and have been proven by multiple studies to be very successful. The statins’ effectiveness in reducing LDL (“bad”) cholesterol has produced highly significant reductions in heart attacks and strokes. Although these medications do lower cholesterol levels, their side effects must be considered. Statin drugs can cause liver irritation, reduce CoQ10 levels in the body, are associated with myopathy, and are even linked to a rare and sometimes fatal condition called rhabdomyolysis. These drugs also have a relatively small effect on good (HDL) cholesterol levels. Thankfully, there are safe and effective solutions available that can help you manage your cholesterol levels naturally. However, first we must review what we know about cholesterol and heart disease.

Cholesterol is a fat-like substance needed to help digest fats, strengthen cell membranes, make hormones and insulate nerves. Although it is found in every cell of the body, cholesterol is mainly made in the liver, as well as cells lining the small intestine. Even though our bodies make all the cholesterol we need, we also get cholesterol from the foods we eat, such as egg yolks and organ meats. All foods from animal sources contain cholesterol, while plant derived food, including peanut butter and avocado, contains no cholesterol at all.

Cholesterol is important to many functions of the body. However, too much cholesterol in the bloodstream is extremely dangerous. After blood cholesterol Reaches high levels, it builds up on the artery walls, and thus increasing the risk for blood clots, heart attack, and stroke. If the cholesterol clogs any of the coronary arteries, the heart’s supply of oxygen and nutrients will diminish, resulting in coronary heart disease, angina, or even heart attack.

Because cholesterol and other fats can’t dissolve in the blood and thereby can’t travel on their own, they have to be transported to and from the cells by lipoproteins. The two major lipoproteins are low density lipoproteins (LDL or “bad cholesterol) and high density lipoproteins (HDL or “good cholesterol”) LDLs carry cholesterol throughout the body to the cells and cause artherosclerosis by clogging up our arteries with fat. On the other hand, HDL prevents the fat buildup by carrying it away from the arteries and to the liver where it can be eliminated. Although high levels of LDL are associated with cardiovascular disease, high HDL can drastically reduce your risk of heart disease. As a result, the AHA has established three guidelines to keep your heart healthy: HDL levels about 40 for men and above 50 for women, LDL levels between 100 and 159, and a total cholesterol (HDL and LDL) of under 200.

Triglycerides are fats used as fuel by the body and a source for metabolism. These levels can fluctuate easily but increased levels are almost always a sign of too much carbohydrate and sugar intake. High amounts of triglycerides make the blood less capable of transporting oxygen and are another factor for cardiovascular disease. Thankfully, the HDL and LDL blend mentioned earlier can safely and effectively lower triglyceride levels.

It has been shown that high levels of HDL cholesterol are inversely related to coronary artery disease risk. However, what people do not know is that there are different subtypes of HDl, including HDL-2 and HDL-3. HDL-3 is produced by the liver and intestines and is responsible for scooping up free cholesterol from the blood vessel walls. The cholesterol carried by HDL-3 is chemically modified, forming a larger-sized subtype, known as HDL-2, or “mature HDL.” HDL-2 transports cholesterol to the liver for processing and elimination, and its molecules are then recirculated in the blood stream. Research has shown that HDL-2 provides more heart-protection because it moves the cholesterol away from arterial walls, and holds a greater number of receptor sites which allows it to carry a larger amount of cholesterol to the liver.

Although many prescription medications have been developed to lower bad cholesterol, there are very few medications that target good cholesterol. Therefore, patients with naturally low HDL cholesterol, who can not alter these levels through diet and exercise, have limited medical options to reduce their risk of heart disease. Multiple nutrients have been clinically shown to favorably alter good cholesterol levels including: vitamins C, E, B6, B12, niacin, folic acid, magnesium and selenium, with protein-building amino acids, powerful antioxidants such as coenzyme Q10, alpha lipoic acid, N-acetyle cysteine, and policosanol, and extracts of hawthorn, garlic, grape seed, and soy isoflavones. Although this HDL-boosting combination does not result in a significant reduction in LDL, antioxidants found in this formulation can help stabilize LDL and prevent build up in the arterial wall.

This formula combines essential vitamins and minerals, at levels recommended by the American Heart Association. It contains amino acids, antioxidants, and botanicals that have all been used safely for years. No serious adverse effects have been found following supplementation and the combination is safe to use with statin drugs.

Plant sterols, found in nuts, vegetable oils, corn, and rice are structurally similar to cholesterol and are able to block its absorption. Each day the liver receives about 800 mg of cholesterol from intestinal absorption through receptor sites. After entering these channels, the cholesterol is absorbed into the bloodstream. Since plant sterols look similar to cholesterol, they fit perfectly into these receptor sites and block the absorption, which allows the cholesterol to remain in our intestines where it can eventually be excreted. A large amount of plant sterols reduces the amount of cholesterol transported from the intestinal tract to the liver. This cholesterol reduction causes a decrease in LDL levels.

Even if a person does not have high cholesterol levels, reducing bad and raising good cholesterol greatly reduces their risk for ever developing chronic heart disease. Due to side effects, physicians do not normally prescribe statin drugs to people without actual heart disease of high LDL cholesterol levels. Instead, they recommend dietary changes. The HDL-boosting combination and LDL-lowering pantethine and plant sterols blend can effectively help people with heart disease, uncontrolled cholesterol levels, high triglyceride levels, or people who just want to improve their heart health.



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Vitaberry Plus + Super Fruit Antioxidant
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Date: December 07, 2005 05:43 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitaberry Plus + Super Fruit Antioxidant

Vitaberry Plus +™ Super Fruit Antioxidant

By Nilesh Patel, NOW Quality Assurance, April 20, 2005 Why are FRUITS AND VEGETABLES important? “Diets rich in FRUITS AND VEGETABLES may reduce the risk of some types of cancer and other chronic diseases.”- National Cancer Institute. OXYGEN AND ANTIOXIDANTS As we all know, “Oxygen is critical to life,” but is itself a double-edged sword. While oxygen is necessary to sustain life and for natural defense against microbes, too much oxygen in our cells can lead to the production of “free radicals” (mitochondrial respiratory chain) or ROS (Reactive Oxygen Species). Free radicals come in many forms - singlet oxygen, hydrogen peroxide, superoxideperoxynitrite, to name a few - but all have one commonality. Each has an unpaired (unbalanced) electron, a situation it remedies by stealing an electron from a stable molecule. This sets off a domino effect of oxidation, a chain reaction that usually ends up damaging cellular integrity and compromising overall health. Nature has a defense system in place to protect these processes in the form of antioxidants. Whether endogenous (produced by the body, such as liver enzymes, SOD, coenzymes and sulfur-containing compounds) or exogenous (obtained through the diet, such as vitamins C & E, bioflavonoids, carotenes, etc.), antioxidants “quench” free radicals by donating an electron to stabilize a molecule, thus controling the chain reaction and stopping the oxidation “domino effect”. ANTIOXIDANT-RICH FOODS Research suggests that eating plenty of foods high in antioxidants helps to slow the processes associated with aging and protect against many chronic diseases. Maximizing one’s antioxidant power will enhance overall health. Fruit and vegetables contain both nutritive and non-nutritive factors that can affect oxidative damage and enzymatic defense and might contribute to redox (antioxidant and prooxidant) actions. A new “6-a-day” study looked into the effects of fruits and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers by The Danish Institute for Food and Veterinary Research in Denmark. The study found that fruits and vegetables increase erythrocyte glutathione peroxidase activity and resistance of plasma lipoproteins to oxidation more efficiently than do the nutritive factors (vitamins and minerals) that the fruits and vegetables are also known to contain. Certain berries, such as blackberries, also contain salicylates, which are also linked to heart health and prevention of atherosclerosis. The protective effects of fruits and vegetables intake on both heart disease death and deaths in general have previously been demonstrated but researchers at the Human Nutrition Research Center on Aging at Tufts University, Boston. Quercetin is an anti-oxidizing flavonoid found in many berries (such as cranberries, bilberries, blueberries, strawberries, etc.) and can prevent CVDs (coronary vascular diseases), according to a recent Finnish study. All these natural plant polyphenols are responsible for the colors of many red and purple berries, fruits, vegetables and flowers. GOVERNMENT GUIDELINES The new federal guidelines released earlier this year by the U.S. Department of Health and Human Services (HHS) and U.S. Department of Agriculture (USDA) recommend eating more fruits and vegetables, combined, than any other food group -- five cups or about 10 servings a day for most adults. The amount of fruits and vegetables recommended has increased for men and women of every age. “Fruits and vegetables are the "good news" story of the new Dietary Guidelines for Americans for food-loving consumers, the industry and America's public health”, stated the Produce for Better Health Foundation (PBH). Eating a variety of colorful phytochemical-rich fruits and vegetables has been associated with lower risk of some chronic diseases such as cancer and heart disease. Many authoritative organizations such as the National Cancer Institute and The American Heart Association recommend getting phytochemicals from whole foods, such as fruits and vegetables, rather than from individual component supplements. The Scottish government is promoting healthy eating through a scheme designed to increase purchasing of fruit and nutritional foods. Scottish health minister Andy Kerr said, "This initiative shows that healthy eating can be good for customers and good for business." Scottish women are said to have the highest rates of death from lung cancer in the world as well as the highest rates in Europe for coronary heart disease. They also have low consumption of fruits and vegetables, shown in studies to help protect against some cancers and benefit heart health. ROS (Reactive Oxygen Species) Free radicals and oxygen free radicals play an important role in the development and progression of many brain disorders such as brain injury, neurodegenerative disease, and Down syndrome. Oxidative stress is an important factor in the etiology and pathogenesis of diabetes & is also linked to other host of degenerative health conditions. Fortunately, antioxidants are available to support the body’s defense and fight disease and aging. Examples of “Fast acting antioxidants” in the body (serum) are: uric acid (polyphenols), ascorbate, bilirubin, vitamin E (the later two are lipid soluble). Examples of “Slow acting antioxidants” are glucose, urea nitrogen etc. In short, free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated as by-products of normal cellular metabolism. Their deleterious effects are minimized in vivo (in the body) by the presence of antioxidant systems. How do Antioxidants work? Antioxidants are substances in plants that help maintain health. Antioxidants protect against damage to cells caused by too many “free oxygen radicals,” which form because of the effects of oxidation. Smoking, sunlight, heavy exercise, and pollution all increase oxidation in the body. Most people would benefit by eating more (five to nine or more servings) fruits and vegetables & colorful plant foods, such as purple, dark green, yellow, orange, blue, and red ones, each day. These have healthful pigments along with antioxidant nutrients such as vitamin C, carotenoids, beta-carotene, lycopene, lutein, zeaxanthin, vitamin E, selenium, flavonoids, and other beneficial substances. There are numerous ways in which these antioxidants affect, but can be explained in two groups: Alpha (a) Effects: This refers to the scavenging or neutralizing of free radicals. These effects do not change the way humans (or animals) feel. There are also no noticeable health, psychological or emotional benefits. While there are no obvious changes, increased total antioxidant intakes are associated with decreased tumor rates, prevention of heart attacks and increased longevity. Beta (ß) Effects: These are the changes on health, psychological or emotional state that you or others will notice. In this case, the antioxidant is affecting metabolic processes (enzymes) with consequent changes in the physical (improvement in joint movements, improved skin condition, tissue damage recovery), emotional (better ability to cope with stress) or psychological state (increased alertness). The ORAC value Because most of the active nutritional components in fruits and vegetables are antioxidants, accurate measurement of antioxidant activity serves as a good indicator of potential health benefit. Scientific opinion runs high that ORAC (Oxygen Radical Absorption Capacity) will eventually become a government standard of reference for overall daily fruits and vegetables intake. ORAC units are a measurement of the ability of food to stop oxidation. It is most generally expressed in terms of Trolox equivalent per gram (µmole Trolox equivalents (TE)/g). POPULATION DATA A survey done by the National Research Council indicates that only 10% of the US population consumes the recommended five servings of fruits and vegetables per day. The equivalent to eating 5 mixed servings of fruits and vegetables per day is about 1,670 ORAC units. Based on scientific evidence it is suggested that daily antioxidant intake should be increased to between 3,000 and 5,000 ORAC units per day, per human subject, in order to reach a significant antioxidant capacity in blood plasma and other tissues. WHAT IS NOW DOING TO HELP? In accord with our mission, “To provide value in products and services that empower people to lead healthier lives,” NOW® Foods is introducing an ALL-FRUIT-DERIVED antioxidant product called VitaBerry Plus +™ Super Fruit Antioxidant Vcaps (vegetarian capsules) (product number #3336). At time of manufacture this product provides an ORAC value of at least 2,500 units per serving from a full-spectrum antioxidant blend of fruits containing phytochemicals and phenolic compounds such as anthocyanins, proanthocyanins, chlorogenic acid, ellagic acid, quinic acid, resveratrol , many organic acids, resveratrol and vitamin C. VitaBerry Plus +™ is formulated with VitaBerry™ Hi-ORAC Fruit Blend [a proprietary blend of fruit extracts & concentrated powders containing Wild Blueberry (Vaccinium angustifolium) extract, Grape (Vitis vinifera) & Grape seed extract, Raspberry (Rubus idaeus) & Raspberry seed extract, Cranberry (Vaccinium macrocarpon), Prune (Prunus domestica), Tart Cherry (Prunus cerasus), Wild Bilberry (Vaccinium myrtillus) extract & Strawberry (Fragaria virginia)], Hi-Active™ Orange (Citrus sinensis) and Pomegranate (Punica granatum) min. 40% ellagic acid fruit extract. One gram of VitaBerry™ Hi-ORAC Fruit Blend provides at least 6,000 ORAC units (i.e., µmole Trolox equivalents (TE)/g). (Also watch for an upcoming antioxidant product from NOW called Enzogenol® (Pinus radiata bark extract from New Zealand) with Rutin (a flavonoid from South American fruit of Dimorphandra mollis) and Grapeseed extract. IS IT EFFECTIVE? Total ORAC value includes both lipophilic and hydrophilic components. VitaBerry Plus +™ contains only water/hydroethanol based extracts and concentrated (100:1 to 125:1) freeze-dried fresh fruit blends, so the lipophilic ORAC value is mere 2-4% of the total ORAC value. Glutathione peroxidase is a selenium-containing enzyme that decreases cell death from brain injuries. It also acts as a critical first-line antioxidant defense on the airway (respiratory) epithelial surface against ROS and RNS (reactive nitrogen species. Genetics research has found that the glutathione S-transferase gene controls the onset of Alzheimer’s, Parkinson’s disease etc. Taking glutathione (GSH) itself as a supplement does not boost cellular glutathione levels, since it breaks down in the digestive tract before it Reaches the cells. So glutathione precursor dietary supplements (such as NAC and GliSODin), along with fruits and vegetables, are effective in boosting intracellular levels of GSH. The lungs have a defense system against the ROS oxidants consisting of low molecular weight antioxidants such as GSH and intracellular enzymes such as SOD, catalase and glutathione peroxidase to protect against the toxic effects of oxidants generated within the cells. Some of the primary effects of VitaBerry Plus +™ against the common reactive free-radical species or ROS are as follows: - Superoxide dismutase-SOD (destroys Superoxide radicals),
- Catalase (neutralizes peroxides),
- Functions similar to reduced Glutathione (GSH),
- Glutathione peroxidase enzyme (detoxifies peroxides, using GSH as a reducing agent),
- Functions similar to Glutathione S-transferase (GST),
- Nullifies Superoxide-generating NADH/NADPH oxidase system In conclusion More concentrated than fresh berries, with over 6000 ORAC units per gram, VitaBerry Plus +™ provides consumers with the antioxidant power of almost 15 servings per day of FRUITS AND VEGETABLES ina convenient vegetarian capsule form! VitaBerry™ PLUS +™ (# 3336) provides a powerful, convenient way to supplement diets that do not include sufficient fruit and vegetable antioxidants Selected References: USDA/HHS guidelines report at: etaryguidelines/dga2005/document/

ls.com/proprietary/pdf/VitaberryBrochure.pdf g Kaplan M., Hayek T. , Raz A., Coleman R. and Aviram M. Pomegranate juice supplementation to apolipoprotein E deficient mice with extensive atherosclerosis reduces macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 131: 2082-2089 (2001) Lars O Dragsted et. al., The 6-a-day study:effects if fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. American Journal of Clinical Nutrition, Vol. 79, No. 6, 1060-1072, June 2004 Fuhrman B. and Aviram M. Polyphenols and flavaonoids protects LDL against atherogenic modifications.In: Handbook of Antioxidants Biochemical, Nutritional and Clinical Aspects, 2nd Edition. Cadenas E & Packer L (Eds.) Marcel Dekker, NY(Pub.). 16:303-336 (2001) Wood, Jacqueline, et al. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry 77 (2002) 155-161 Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. Free Radical Research 36 (Supplement 1): 71-72 (2002) Jennifer Schraag, Antioxidants: Nature’s Way of Balancing Life. HSR Health Supplement Retailer, Vol. 11, No. 2, 24-27, February 2005 com/news/printNewsBis.asp?id=58665 com/news/printNewsBis.asp?id=58697

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GPC (GlyceroPhosphoCholine) Versatile Life Support Nutrient ....
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Date: June 21, 2005 05:25 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GPC (GlyceroPhosphoCholine) Versatile Life Support Nutrient ....

GPC (GlyceroPhosphoCholine): Versatile Life Support Nutrient

Parris Kidd, Ph.D.

  • GPC - Marked Benefits to the Brain
  • GPC Supports Normal Brain Function
  • GPC Works Through Multiple Mechanisms
  • Dosing, Safety, Tolerability, Compatibility
  • GPC: Nutrient for All Ages
  • GPC or GlyceroPhosphoCholine (pronounced gli-sero-fos-fo-ko-lean) is a nutrient with many different roles in human health. It Reaches extremely high concentrations within our cells, and its abundance in mother's milk suggests it is crucial to life processes. Clinically, GPC has been most intensively researched for its brain benefits. Biologically, it has great importance for the skeletal "voluntary" muscles, the autonomic nervous system, kidneys, liver, and reproductive organs. GPC goes beyond being a brain nutrient; it is a nutrient for vitality and long life.

    Marked Benefits to the Brain

    As a dietary supplement, GPC's brain benefits are unique. It boosts mental performance in healthy young people, as shown by three double-blind trials. In trials on middle aged subjects, GPC improved several physiologic measures of mental performance: reaction time, visual evoked potential, and EEG delta slow waves. In the elderly, GPC improves mental performance and provides noticeable revitalisation. In 11 human trials with 1,799 patients, memory, attention, and other cognitive measures improved. So did mood (including irritability and emotional lability), and patients often developed renewed interest in relatives and friends. GPC was well tolerated, and generated no bad drug interactions. A large trial on elderly subjects with memory challenges published in 2003 concluded GPC had significant benefits for these individuals.

    GPC Supports Normal Brain Function

    Circulatory deprivation or surgery can challenge healthy brain function. GPC can speed recovery and support improved quality of life. In four trials with GPC on 2,804 subjects who experienced difficulties under these circumstances, up to 95% showed good or excellent improvement. GPC consistently improved space-time orientation, degree of consciousness, language, motor capacity, and overall quality of life. The investigators concluded GPC offered marked benefits, with an excellent benefit-to-risk profile. Up to half of patients who survive bypass surgery experience problems with memory and other mental performance. A double-blind trial conducted with bypass survivors for six months determined that the GPC group had no remaining memory deterioration, while the placebo group failed to improve.

    GPC Works Through Multiple Mechanisms

    GPC supports human health through a variety of mechanisms:

    1. It helps keep choline and acetylcholine available to the tissues. Choline is an essential nutrient and GPC appears to be the body's main choline reservoir. GPC in mother's milk represents the baby's main source of dietary choline. Acetylcholine (ACh) is an important substance employed extensively throughout the body. ACh is a major brain transmitter; the motor nerves use ACh to drive the skeletal ("voluntary") muscles; the autonomic nervous system uses it to pace all the organs. ACh is also central to mental and physical endurance, and mind-body coordination.

    2. GPC is a major cell-level protectant, not as another antioxidant but in pivotal roles of osmotic pressure regulator and metabolic antitoxin. GPC for osmotic regulation can reach very high concentrations in the kidney, bladder, liver, brain, and other organs. As metabolic protectant, GPC shields proteins against urea buildup.

    3. GPC is a major reservoir for cell membrane omega-3 phospholipids. These substances are the major building blocks for cell membranes. Enzymes couple GPC with the omega-3 fatty acid DHA, to make the phospholipid PC-DHA. This makes membranes especially fluid, enabling membrane proteins to perform with better efficiency. GPC produces PC-DHA in the skeletal muscles, wherein fluidity is essential for contraction. Muscles that function abnormally can show GPC deficiency.

    4. GPC contributes to both male and female in reproduction. As spermatozoa mature, GPC is used to make PC-DHA that makes their membranes fluid to enable motility. With men, the lower their semen GPC the greater the likelihood of poor sperm motility and with it, infertility. Once semen is inserted into the female, an enzyme in uterine secretions breaks down the semen's GPC into substances that energize the sperm to achieve fertilization.

    Dosing, Safety, Tolerability, Compatibility

    Oral intake of GPC in the clinical trials was usually 1,200 milligrams (mg) per day, taken early in the day on an empty stomach. A reasonable dietary supplementation regimen is 1200 mg/day, taken in divided doses (AM and PM) between meals for 15-30 days, and thereafter 600 mg/day for maintenance. Symptomatic subjects can take 1200 mg/day until adequate improvement is achieved. Young, healthy subjects may experience benefit from daily intakes as low as 300 milligrams. GPC is very safe, being compatible with vitamins and nutrients and with pharmaceuticals. In clinical trial comparisons, GPC's benefits surpassed the nutrients acetylcarnitine and CDP-choline.

    GPC: Nutrient for All Ages

    GPC is unmatched for its support of active living and healthy aging. In some 23 clinical trials GPC improved mental performance in all functional categories. GPC can revitalize the aging brain, facilitating growth hormone (GH) release and boosting nerve growth factor actions. GPC's ample presence in human mother's milk suggests it could be conditionally essential. By supporting mental integrity, mind-body integration, the autonomic system, and the body's other organs, GPC enhances the active lifestyle. GPC is remarkable nutritional support for optimal health at any age.

    Parris M. Kidd, PhD is a cell biologist trained at the University of California, Berkeley and San Francisco. Since entering the dietary supplement field in 1983, he has published many in-depth reviews of integrative medicine in the journal Alternative Medicine Reviews, and is science columnist for totalhealth magazine. Dr. Kidd is internationally recognized for his accomplishments in dietary supplement product development, documentation and quality control.

    Disclaimer: the above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider.



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    Gotta Habit
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    Date: June 14, 2005 06:26 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Gotta Habit

    Gotta Habit

    by Catherine Heusel Energy Times, October 1, 1998

    Quitting a bad habit presents quite a challenge. Just ask anyone who's ever tried to give up cigarettes. Or alcohol. Or even coffee. You start out with the best of intentions but cravings can push you off the straight and narrow. The result: giving up a nasty habit often means regenerating your resolve and trying again. And again. And again. While some blame an inability to give up a bad habit on poor will power, in actuality, the tenacious chains of these habits may derive from the body as well as the mind. "People don't seem to realize the effects these substances have on the body," says Joan Mathews-Larson, Ph.D., director of the Health Recovery Center, in Minneapolis, and author of Seven Weeks to Sobriety. Dr. Mathews-Larson is one of a growing number of addiction professionals who stress physical recovery when giving up a drug, whether it's caffeine or cocaine. "You can't disrupt your internal chemistry for months or years on end and then expect your body to automatically bounce back," she says. "You have to give it some help."

    Breaking Off is Hard to Do

    The substances we love to overdo all share a common characteristic: they mimic or enhance the body's chemical messengers. Opiate drugs such as heroin, for example, are virtually identical to substances called endorphins, neurochemicals that the body produces to mask feelings of pain. (When an injured Kerri Strug performed her final Olympic vault, her endorphins enabled her to push past her protesting nerve endings.) Stimulants such as caffeine and nicotine can provide a "rush" similar to that produced by adrenaline and noradrenaline, the neurochemicals that provide the quick and excited feeling that swells down your spine during frightened or thrilling moments. On the other hand, some drugs (notably alcohol and cocaine) boost the activity of several different neurochemicals, including those that control sensations of pleasure. From a biological perspective, then, none of the drugs that people take are totally unfamiliar to the body. Your body makes similar chemicals all the time, in response to specific events and needs. "The main advantage of drugs is that they act powerfully and immediately," explains Andrew Weil, M.D., in his book, From Chocolate to Morphine: Everything You Need to Know About Mind Altering Drugs. "Their main disadvantage is that they reinforce the notion that the state we desire comes from something outside us."

    Serious Disadvantage

    Another serious disadvantage of drugs resides in their impact on the body's everyday neurochemical balance. Under normal circumstances, the body maintains its internal chemical environment on a fairly even keel. It may pump out oodles of adrenaline in response to a specific threat, like a near miss on the highway, but for every such scary "high" a corresponding low sets in: that rubbery-kneed sense of relief you feel when things calm down.

    Over time, the body mistakes the introduction of mind-altering, foreign chemicals as an excess of its own production of neurochemicals. As a result it slows down its own manufacture of these vital substances. So when you stop drinking caffeine or other stimulating drugs, the body finds its neurochemical receptors begging for relief: Cravings raise their ugly heads while so-called withdrawal symptoms raise your discomfort level. A general sense of ill health sets in until the body's natural production of neurotransmitter production Reaches an acceptable level.

    Healthy Behavior

    Breaking a bad habit may be complicated by a lack of regenerative health habits. "A proper diet is pretty low on an addict's list of priorities," says Mathews-Larson. "Most of the people we see live on fast food and junk food." Many people trying to give up bad habits are attacked by the chemical and physical problems resulting from eating fatty foods and not exercising: their bodies are chemically and physically challenged from a poor lifestyle.

    Fortunately, recovery from a bad habit can be enhanced by balancing your diet, exercising and using nutritional supplements to straighten out your interior biochemical environment.

    "We target substances that are essential for maintaining optimal brain chemistry," points out Mathews-Larson. Foremost among these substances are a variety of amino acids that the body needs to rebuild its supply of neurotransmitters. In addition, nutrients such as B vitamins and vitamin C are often in short supply among those who indulge in addictive drugs and alcohol.

    Exercise and meditation are equally important to recovery, since both activities naturally prompt production of mood-enhancing neurochemicals. (The so-called "runner's high" is believed to result from endorphins and other neurochemicals stimulated by jogging.) More importantly, natural stimulation that pushes the body to create its own, endogenous supply of feel-good chemicals produces a longer sense of well-being than the transitory high induced by drugs and alcohol. "The potential for highs is always there, and many techniques exist for eliciting them," declares Dr. Weil. "Drug highs differ from other highs only in superficial ways."

    Natural Appreciation

    To experienced treatment professionals such as Mathews-Larson, kicking a long-standing habit depends on learning to appreciate the natural high of good health, through an overall healthy lifestyle. "It's not enough to just stop using the substance you abused," she contends. "You have to build a high quality of life for yourself, so you can fully enjoy every day."

    Recommended Reading: Seven Weeks to Sobriety, by Joan Mathews-Larson (Fawcett Books, 1997) Healing Anxiety With Herbs by Harold H. Bloomfield. (Harper Collins, 1998.)



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    Don't Be Blue - Does winter got you singing the blues?
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    Date: June 13, 2005 09:49 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Don't Be Blue - Does winter got you singing the blues?

    Don't Be Blue by Phyllis D. Light, RH Energy Times, October 10, 2003

    Have the gray skies of winter got you singing the blues? Do you feel tired, lost your creative spark, need extra sleep, can't get control of your appetite? If you nod in agreement to these queries, you may be one of the millions of people affected by SAD (seasonal affective disorder), also known as the "winter blues" or "cabin fever." Time to lighten up, throw off those lowdown winter blues and step up to more enjoyable feelings. Experts who study the winter blahs now acknowledge that you can blame much of winter's crankiness, moodiness and restlessness on short, cloudy days and a lack of sunlight. Low levels of sunlight trigger changes in hormones, increasing levels of melatonin (a hormone that normally helps you go to sleep) and decreasing serotonin (a hormone that improves mood). For many people, this hormonal tumult translates into a craving for sugary foods, a need for more sleep and a reduced sex drive.

    Although the exact cause of SAD is not known, researchers believe the pineal gland plays an important role in this disorder. This gland, located beneath the brain, makes melatonin in response to the amount of light that enters your eyes. Melatonin hormone is only produced in darkness. The darker your bedroom, the greater your melatonin production.

    Conversely, melatonin production usually stops in the morning when you open your eyes to the day's new light. But research shows that the production of melatonin climbs too high in folks who suffer from SAD. That excessive amount of the hormone results in a sedative effect upon the body.

    Many people with SAD suffer muscular aches and pains, along with headaches and a faltering immune system. Consequently, they often feel like they have the flu all winter long.

    Blue Lady

    More women than men suffer from SAD (and, apparently, depression in general), though the reason is unclear.

    According to Norman Rosenthal, MD, author of Winter Blues (Guilford Press), "about 6% of the US population may suffer from SAD, with an additional 14% suffering from subsyndromal [less severe] SAD." Because less sunlight Reaches the northern latitudes, folks in Washington state and Alaska suffer the highest rates of SAD. People in sun-soaked Florida suffer the least.

    How do you escape SAD? If a winter vacation to the sunny South is out of the question for you, a natural program can brighten the wintry gray days and provide relief.

    Turn on the Light

    The most common treatment for SAD is light (also called phototherapy), which cuts back the body's manufacture of melatonin. Sitting in front of a special light box for about 30 minutes each morning during the winter months can often offset SAD. But the effects of this treatment vary from individual to individual, and some may be more sensitive to the light therapy than others.

    For artificial light treatment, consult an appropriately trained healthcare professional who can design a plan that finds the optimal intensity, length and time of day for the treatment that best works for you. Researchers at Columbia University have found that timing the light therapy with the nuances of a person's biological clock doubles its effectiveness (Archives of General Psychiatry 1/15/01).

    On the other hand, walking in natural light can banish these problems, and research finds that natural light frequently offers the best results (Journal of Affective Disorders 1996 Apr 12; 37(2-3):109-20). In this study, people either participated in a daily walk outdoors in natural light or were treated for half an hour in artificial light. At the end of the study, participants were tested for melatonin and cortisol (stress hormone) levels. Both were found to be lower after exposure to natural light than artificial light.

    Roll up those sleeves when you're outdoors this winter: Curiously enough, studies show that light produces physiological effects by being absorbed through both the eyes and the skin.

    Research now shows that light on the skin alters the hemoglobin in the blood. "This research suggests that SAD might be a disorder of the blood rather than a brain disorder," says Dan A. Oren, MD, of the Yale University School of Medicine (Science 1/12/98).

    Vitamin D Need

    If you suffer from seasonal depression, you may also not be getting enough vitamin D. During the sun-reduced winter months, stores of this fat-soluble vitamin drop, since the skin makes it when exposed to sunlight. When you step out into daylight, the sebaceous glands near the surface of your body produce an oily substance from cholesterol that rises to the skin's surface. Then, ultraviolet B rays from the sun convert this oily substance (7-dehydrocholesterol) into what is called previtamin D3. Finally, body heat converts previtamin D3 into vitamin D3 (a form of vitamin D).

    Twenty minutes of daily sunlight exposure on the hands, arms and face can give adequate amounts of vitamin D to light-skinned people. Dark-skinned people may need longer exposure. Supplements can help: In one study, researchers found that people who took vitamin D had significant improvement in depression scale scores (Journal of Nutrition, Health & Aging 1999; 3(1):5-7).

    As far as vitamin D production goes, you can never receive too much sunlight (although overexposure resulting in a burn is never a good idea). The body absorbs vitamin D from the skin as needed and never accepts more than is required. (If you take supplements, follow package directions so you don't get too much of a good thing.) Food sources of vitamin D include eggs, fortified milk, cod liver oil, salmon and other fish.

    Walk Away the Blues

    Research also shows that exercise can chase the winter blues and that a little bit of exertion goes a long way. Exercise physiologists at Duke University found that little as eight minutes of physical activity can improve your mood.

    Exercise stimulates the brain to produce endorphins, feel-good hormones that help reduce pain and depression. Physical activity can also increase serotonin levels, those neurotransmitters that brighten emotions. These two hormones work together to make you feel better: Serotonin improves the functioning of your mind while endorphins produce beneficial effects on your body. In one study, researchers reported that exercise increased vitality and improved mood even in cases of prolonged depression (Psychological Medicine 1998 Nov; 28(6):1359-64).

    To banish SAD, engage in an outdoor activity in natural light, or get active indoors under bright lights.

    As you can see, much of the research into low, wintry moods suggests that sun worshippers may have been right all along: Exposure in winter to our friendly, local neighborhood star offers impressive mood benefits.



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    Vitanet ®

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    Down with Blood Pressure
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    Date: June 12, 2005 08:03 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Down with Blood Pressure

    Down with Blood Pressure by Kim Erickson Energy Times, January 6, 2002

    More than one of four Americans suffers from high blood pressure, also known as hypertension. This so-called silent killer is often the first step in developing long-term problems like heart disease and stroke. According to the American Heart Association, high blood pressure leads to about 45,000 deaths a year and contributes to another 210,000. Hypertension is more common in women beginning at age 50, particularly African-American women. And since high blood pressure rarely causes obvious physical distress, unless your health practitioner monitors your blood pressure on a regular basis, it's easy to miss. The famous study by the National Heart, Lung and Blood Institute (NHLBI), known as the Framingham Heart Study, found that half of all people who suffered a first heart attack and two-thirds of first-time stroke victims also had moderate to high blood pressure. What's more, left untreated, high blood pressure can also increase the risk of atherosclerosis (hardening of the arteries), aneurysms, loss of vision and kidney failure. Normal blood pressure is considered 120/80. When blood pressure Reaches 140/90 or above on a consistent basis, you have high blood pressure. What do the numbers mean? The top number, systolic pressure, represents the peak pressure generated in your arteries when your heart beats. The bottom number, diastolic pressure, indicates the pressure when your heart is at rest between heartbeats. Among 95% of all people with high blood pressure, health practitioners can generally pinpoint no specific, single cause.

    So Salty

    For decades, the most common recommendation for people with high blood pressure was to eat less salt. Experts have advocated reducing our salt intake to no more than three teaspoons a day: six grams (2400 mg), which is four grams less than the current national average. This recommendation was largely based on a study conducted by Northwestern University Medical School in Chicago, Illinois, known as INTERSALT. The study tested more than 10,000 men and women from 32 countries. The researchers concluded that eating a lot of salt was linked to rises in blood pressure. Other scientists haven't always found the same results. One review of 56 clinical trials by the Integrative and Behavioral Cardiology Program at the Mount Sinai School of Medicine in New York found only a modest reduction in blood pressure when the salt shaker was left unshaken. And an analysis of 58 studies by academics at the University of Copenhagen, Denmark found that, overall, studies did not support a general recommendation to reduce the amount of salt we consume. Added to all this confusion, many people are salt sensitive: their bodies retain excess salt instead of flushing it out of their systems. Unfortunately, only medical tests can reveal this sensitivity. Consequently, experts still recommend that you eat fewer foods containing salt. That means going easy on processed foods, lunch meats and soft drinks. In addition, increasing your intake of potassium, calcium and magnesium may help your blood pressure.

    Mitigating Minerals

    Foods rich in potassium and magnesium not only help regulate blood pressure, but may boost overall cardiovascular health and reduce the risk of stroke. Vegetarian items such as bananas, baked potatoes and oranges are rich in these minerals. Research that looked at 30,000 doctors found that those who ate diets rich in fiber, potassium and magnesium had lower blood pressure than the men who ate few of these mineral-rich foods (Circ, 1992; vol 86:1475-1484). A study of 40,000 female nurses found that their pressure decreased when they consumed fibrous and magnesium-filled foods (Hypertension, 1996, vol 27:1065-1072).

    CoQ10

    The nutrient CoQ10 is a vitamin-like substance which acts as an antioxidant in the body, decreasing the harm caused by caustic substances known as free radicals. Found in every part of the body, CoQ10 is necessary for producing energy in every cell. But it is estimated that nearly 40% of people with high blood pressure are deficient in CoQ10. Tests of CoQ10 seem to show that it can often reduce blood pressure by almost 10% (Cur Ther Res 1990;47: 841-845). It also appears to reduce blood triglycerides, blood fats linked to heart disease, and insulin, while slightly increasing HDL (good) cholesterol.

    Food Fight

    Perhaps the biggest breakthrough in lowering blood pressure without the use of prescription medicine came with a study known as DASH (Dietary Approaches to Stop Hypertension). Funded by NHLBI and the National Institutes of Health, the multicenter study examined more than 400 people with high blood pressure. These folks were divided into three groups. One ate the standard high-sodium, high-fat American diet, the second a diet high in fruits and vegetables, and the third a combination diet rich in fruits, vegetables and low-fat dairy products (the DASH diet). While the group eating plenty of fruits and vegetables enjoyed a modest reduction in blood pressure, the study found that combining low-fat dairy with produce lowered both systolic and diastolic blood pressure by 11.4 and 5.5 points, respectively. And the benefits came quickly. Many of the people on the combination diet lowered their blood pressure within two weeks. The results were so impressive that researchers at Brigham and Women's Hospital in Boston, Massachusetts suggested that the DASH diet may offer an alternative to drug therapy for people with hypertension and may even serve to prevent high blood pressure altogether. The DASH diet is low in saturated fat and rich in whole grains, fruits and vegetables. Similar to the diet found in Mediterranean cultures, DASH also includes nuts, seeds and legumes, and is supplemented by non- or low-fat dairy products. Moderate amounts of protein-in the form of fish, poultry and soy-are also eaten. Eating in the DASH may also spur weight loss. Since being overweight can increase your blood pressure, the NHLBI strongly recommends a low-calorie diet such as DASH to take off extra pounds. Exercise and stress relief play critical roles in most pressure-reducing plans. Working out not only helps shed weight, it can also lower your blood pressure. Low to moderate aerobic exercise four days a week may lower blood pressure just as effectively as a higher intensity workout. And learning how to manage stress has helped dropped pressures in people with hypertension (Arch Intern Med 2001; 161:1071-80). Nutrition and lifestyle: two vital relief valves for dropping your high blood pressure and increasing your chances of longer life.



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    Summer Sports Nutrition Guide
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    Date: June 11, 2005 03:54 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Summer Sports Nutrition Guide

    Summer Sports Nutrition Guide by Joyce Dewon Energy Times, June 18, 2004

    If you're hooked on exercise you're probably just as hooked on using top-notch equipment when you work out. Those who are serious about staying in shape buy the best running shoes, carefully pick out the best bikes and tread on durable treadmills. But do you pay just as much attention to your nutrition?

    Scientists who have studied exercise have found that what you eat before, during and after workouts is crucial to maintaining your health, getting into shape and staying fit. To achieve your best athletic performance without getting injured or sick depends on optimum nutrition. When you carefully plan what to feed your exercised body, it rewards you by feeling and looking better.

    Short 'n Sweet

    If you thought long exercise sessions were the only ways to get decent exercise benefits, take notice: small doses of exercise during the week can go a long way. " The important thing, apparently, is just do it," says Howard D. Sesso, ScD, author of an American Heart Association study on exercise and heart disease. In his study, exercisers demonstrated that several short sessions of exercise were as good for the body as a single long session (Circ 8/00; 102:975-80). " Short sessions lasting 15 minutes long appear to be helpful,"Dr. Sesso explains. Even walking about three miles per week, which is a moderate level of exercise, lowers your risk of heart disease by 10%.

    No Sweat?

    Some people glorify in working up a sweat; others curse the dampness. But putting in extra effort in even short bursts of activity pays off: experts have found that intense exercise burns more calories than more relaxed sessions, more effectively reduces your risk of cardiovascular disease and helps stabilize blood sugar levels. In addition, it stimulates production of human growth hormone, which offsets some of the effects of aging (Exp Biol Med 2004 Mar; 229(3):240-6).

    But don't go crazy if you haven't worked out in a long time. The intensity of the workout should match your physical fitness. According to the American Heart Association, when people exercise at a comfortable pace, their heart rate and level of exertion stay within a safe range, but still high enough to benefit their health. Strenuous activities, for those who can handle them, produce the most physiological bang for the jog. But brisk walking within your own level of fitness still offers significant benefits.

    Feeding Your Muscles

    When you exercise, you work and develop your muscles, which are made primarily out of protein. Despite this fact, many exercise experts have advocated high-carb diets for athletes. But, as John Ivy, PhD, and Robert Portman, PhD, point out in their book The Performance Zone (Basic Health), "[While] there is no doubt that aerobic athletes require more carbohydrate than strength athletes...we are now discovering that the addition of protein to a carbohydrate supplement offers significant benefits to aerobic athletes."

    That is why researchers believe that consuming plenty of protein along with carbohydrates offers the best fitness benefits. Protein helps fuel activity more efficiently and aids in recovery after a session at the gym, allowing your body to repair muscle damage and build up muscle fibers.

    During exercise, you break down muscle tissue. It is during recovery, after your exercise session ends, that muscles are rebuilt. At the same time, other cellular processes take place that adapt the body to working out.

    According to Ivy and Portman, timing your intake of nutrients after exercise is crucial: "The ability of the muscle machinery to regenerate itself decreases very rapidly after a workout, so that the nutrients consumed more than 45 minutes after exercise will have far less impact in helping the muscles regenerate than nutrients consumed earlier."

    Stresses and Tears

    Engaging in athletics can cause microscopic muscle tears. These tears can cause a range of problems that, when you exercise excessively, can cause pain and injury.

    Inflammation is the body's response to cellular damage. The damaged area can swell as the body sends white blood cells and other cells to repair the injured area. Unfortunately, the swelling can further damage the muscle cells.

    Since inflammation can take 24 hours or more to cause the collection of cells in the injured area, it can be a day or two before the resulting muscle soreness Reaches its peak painfulness and then starts to subside.

    Cortisol, a hormone produced when you exercise strenuously, which can result in muscle fiber damage. Cortisol boosts protein breakdown, so it can be used to fuel muscle movement. But the more protein breaks down, the more potential exists for muscle fiber injury. Free radicals are caustic molecules that are created when the mitochondria (small structures in cells) create energy; these marauders can also cause microscopic shredding of muscle strands. As you increase your use of energy during exercise, you simultaneously increase the production of free radicals. This collection of free radicals can outstrip the body's antioxidant defenses, leading to extensive muscle damage and dampening of the immune system.

    All of these cellular events can make you sore. They are also the reasons that athletes who overdo it day after day are liable to come down with nagging colds and a variety of infections.

    Muscle Fuel

    Your muscles use different substances for fuel depending on what you ask them to do. Lift a heavy weight and muscles recruit two processes called the creatine phosphate system and glycolysis to generate a large amount of quick energy. These are known as anaerobic types of energy production.

    But if you jog, swim, bike or perform any other aerobic activity, the cells use oxygen in what is called cellular respiration to supply energy to working muscles.

    When you exercise aerobically for extended periods of time, the energy available is generally limited by how much oxygen your body is capable of taking in and supplying to the muscles, where it takes part in energy production. In athletic circles, this upper limit is known as your VO2max.

    The carbohydrates your body burns for energy during aerobic activity are taken from blood sugar and carbohydrate reserves called glycogen. (The muscles store glycogen, as does the liver.) During a workout session, your glycogen supply is limited to what is stored with your muscles. But blood glucose can be boosted by carbohydrate drinks, energy gels or bars.

    Most people who work out have enough glycogen and blood sugar to fuel moderate aerobic activity for about two hours. After that, the body turns mostly to fat and protein stores to fuel exercise.

    Fat Into the Fire

    In contrast to the body's quickly diminishing supply of glycogen and blood sugar, fat can last for hours and hours of exercise. According to Portman and Ivy, a 200-pound man with 15% body fat has, theoretically, enough fat energy to run from Washington DC down to Miami Beach-and still has enough energy left over to jump into the ocean.

    But using fat for energy is complicated; fat is stored in fat tissue and not readily available to working muscles. Plus, to burn fat for energy, the body needs carbohydrate-it cannot burn fat all by itself. What's more, the conversion of fat into energy doesn't go as quickly as carb conversion.

    Protein is also used for energy when carbs run low. But the more you use protein for energy, the more you risk soreness as muscle fibers break down.

    Prepare to Energize

    To maximize your energy during exercise and minimize soreness, Portman and Ivy recommend some simple nutritional steps:

  • • Drink 14 to 20 ounces of water or a sports drink with electrolytes about a half hour before you work out. Consuming fluid helps stave off dehydration longer, helps you sweat more (which cools your body) and moderates the rise in body temperature that takes place during exercise. Portman and Ivy favor sports drinks to help you retain fluid and maintain your mineral balance.
  • • Eat carbohydrates an hour before exercising, which boosts glycogen and increases blood sugar and insulin. Portman and Ivy add that, alternatively, you can also consume a protein/carbohydrate sports drink about half an hour before working out. The protein helps protect muscle protein from being broken down.
  • • Drink small amounts of fluid frequently as you exercise to replace water lost through sweating. While some experts recommend only drinking enough to quench your thirst, most researchers agree that a sports drink with electrolytes is best to ensure proper mineral balance in your body.
  • • Consume carbs and protein during exercise. Portman and Ivy note that soccer players who consume sports drinks that contain electrolytes, carbohydrates and a bit of protein can perform more effectively. Cyclists who go on bike rides of three hours or more enjoy more endurance when they eat energy bars or consume other sources of carb and protein. Portman and Ivy advocate drinks that contain carbs and protein in a 4:1 ratio.

    Limit Soreness

    Taking protein and carbs while working out can limit muscle damage and curtail soreness. Carbs apparently drop your cortisol levels, and thereby limit muscle injuries linked to this hormone. While the mechanism that helps protein limit muscle soreness is not completely understood, it is possible that taking in protein while working out keeps the body from shredding muscle tissue in search of fuel.

    Supplements that contain antioxidants such as natural vitamin E and vitamin C (Portman and Ivy think you should take these during exercise) may limit free radical damage to muscle fibers.

    Muscle Reconstruction Plan

    If you want to help your exercise plan make you stronger, you should focus your after-exercise sports nutrition plan on these steps:

  • • Help your muscles recover from damage during activity and stimulate the rebuilding process
  • • Replace glycogen (carbohydrates) the muscles have used up during your workout
  • • Reinforce your immune system
  • • Replace water and minerals lost in sweat Even after you stop exercising, your muscles are still breaking down, according to Ivy and Portman. The key to putting the brakes on this breakdown and initiating the rebuilding process is by consuming a combination of protein and carbohydrate within 45 minutes after your workout is completed.

    The protein part of the equation is vital: don't merely indulge in only carbs after exercising. A recent study found that while carbs could help muscles rebuild, adding protein can make a big difference in improving your fitness (J App Phys 2/04).

    This combination of nutrients stimulates the pancreas so that it releases insulin. The release of insulin is the key, initial step that sets off a cascade of physiological events that speeds muscle recovery. Although many people think of insulin as an undesirable hormone-if you never exercise, too much insulin may help drive your blood sugar down and cause other problems-for exercisers, this hormone plays a crucial function in benefiting from exercise.

    By eating carbohydrate and protein soon after working out and stimulating insulin, according to Ivy and Portman, you help your body boost its synthesis of protein by:

  • • Increasing the amount of amino acids (protein building blocks) that get into the muscles-this can increase by up to 50%
  • • Increasing the production of protein synthesizing enzymes by up to two-thirds
  • • Slowing the breakdown of muscle proteins

    Drinking for Exercise The most obvious nutrient you lose during intensive exercise is water in your perspiration. However, that perspiration also contains an array of minerals known as electrolytes. So, for optimal performance and health, experts recommend you replace both the water and its minerals.

    Merely drinking water-instead of electrolyte-filled sports drinks-during prolonged aerobic activity can be dangerous. It leaves you vulnerable to a condition called hyponatremia, which can occur when your blood levels of sodium and other electrolytes drop, but your blood volume stays steady or increases because you drink lots of water.

    According to Edmund Burke, PhD, in his book Optimal Muscle Performance and Recovery (Avery), one out of four athletes who seek medical attention after a long race are suffering hyponatremia.

    " Typically," he says, "conscientious athletes get in trouble because they adhere too diligently to one recommendation: the need to drink lots of fluids. They tend to ignore another recommendation: The need to keep electrolytes up...for most endurance athletes the real problem is drinking too much water." Dr. Burke warns that you can possibly suffer hyponatremia even if you don't drink a lot of water.

    Signs of hyponatremia can be similar to those of heat exhaustion. But, while resting and cooling down can help alleviate heat exhaustion, that doesn't help hyponatremia. " To protect yourself against hyponatremia, start by paying attention to how much you sweat," Dr. Burke says. If your sweat seems very salty, burns your eyes or leaves an evident, white residue on your skin, you may be losing a great deal of sodium and should be diligent about eating salty foods. " You can also make sure you're getting enough sodium by drinking sports drinks instead of plain water during long (exercise) events," Dr. Burke notes.

    Exercise Matters

    Of course, no matter what you decide to eat or drink while exercising, the most important factor for your well-being is to get out to the gym, onto the track, or just on to the sidewalk, and do something, even if you only want to go out for a walk. No matter how old you are or what kind of shape you're in, you'll benefit from exercise.

    " It's solid evidence that across-the-board declines occur when people stop exercising," says Charles Emery, PhD, professor of psychology at Ohio State University (Health Psychology 3/04).

    Don't decline or remain supine. Let your fitness climb.



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    What is Hoodia?
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    Date: June 09, 2005 10:39 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: What is Hoodia?

    Hoodia

    1. What is Hoodia? Despite its similar appearance, the cactus-like hoodia is characterized as a succulent plant, which is a member of the milkweed family. Though there are about 20 species within the family, the active ingredient of hoodia is found only in the gordonii variety native to South Africa's vast Kalahari Desert

    2. What assurances can be made that Source Naturals Hoodia Extract is authentic? Experts in succulent horticulture have helped ensure that the raw material Source Naturals uses to make Hoodia Extract is gathered from authentic Hoodia gordonii sources. From there, our supplier has an independent laboratory test the raw material, which is then issued with a certificate of analysis qualifying it as true Hoodia gordonii.

    Once Source Naturals receives the certified Hoodia gordonii from our suppliers, we hold it to our own high standards and Total Quality Assurance. By putting it through stringent testing procedures in our quality control lab, we've carefully scrutinized the material. Before it ever Reaches the hand of consumers, our high-quality hoodia is put through High Performance Thin Layer Chromatographic (HPTLC) analysis for authenticity, and microbiological screening for contamination, as well as other rigorous laboratory protocols.

    3. Could you explain the 20:1 ratio? 20:1 refers to the "wet to dry" ratio of the whole plant to concentrated powder. Hoodia gordonii contains an abundance of excess moisture that needs to be removed in order to make an effective, concentrated powder. The process by which that moisture is removed to yield the powder is an extraction. Basically, 20 pounds of whole plant is concentrated to one pound of the high-quality powder used to make our product.

    What this means is, we've made a supplement with 20 times more functional hoodia than had we ground the plant up water and all. When you buy Source Naturals Hoodia Extract, you're getting all of the usable plant parts of the Hoodia gordonii times 20, because we've packed a greater amount of the quintessential hoodia ingredients into a powerful, concentrated powder.

    4. Is a 20:1 concentrated extract more effective than 1:1 hoodia powder? We at Source Naturals certainly believe so. Unfortunately, the hoodia landscape has been unnecessarily clouded recently thanks to the misinformation circulating about concentrated extracts and so-called "100%" (1:1) hoodia powder. Most of the information is highly subjective, with no studies whatsoever to support claims that so-called "pure" powder is more efficacious than 20:1 concentrated extracts.

    The common selling point for those propagating a 1:1 hoodia product is the notion that "more is better" - which, when you think about it, actually benefits a 20:1 concentrated extract. Because the logic behind using the 20:1 concentrated extract is that, in supplementation, it's not practical to ingest as much of the whole plant parts of hoodia as the San did to get the potential benefits of the plant. In using the concentrated 20:1 ratio, we're able to pack 20 times the amount of usable hoodia into our Hoodia Extract. How much more could you need?

    5. Where was the hoodia in Hoodia Extract grown? On an approved farm in Northern Cape, South Africa.

    6. Who is our supplier? Due to obvious business considerations, we don't want to specifically name our supplier and alert competitors to our source. However you can be assured that we receive our Hoodia gordonii from one of the industry's top suppliers, who was among the first and only importers of hoodia licensed to sell and import the plant into the United States.

    7. I've heard there are sustainability issues with the plant. Is it endangered? It is true that the resources for Hoodia gordonii are limited due to early irresponsibility on those seeking to exploit the plant's benefits. However, Source Naturals Hoodia Extract has been produced with environmental sustainability in mind. We've made absolutely sure that only materials safely cultivated from the stems of seedlings grown on approved farms in South Africa have been used in making Hoodia Extract, not material indiscriminately picked in the wild.

    8. How should it be used? Take one to two tablets or capsules with an 8 ounce glass of water about an hour before eating a meal.

    9. Why does the label warning recommend consulting your health care professional before using this product if you are taking any prescription medication? This is a standard warning included on most Source Naturals product labels because generally it's a good idea to double check with your physician if you're taking prescription medication to make sure there aren't any special precautions you need to take while on the medication.

    10. Does it contain caffeine? No. There is no caffeine in Hoodia gordonii, and Source Naturals Hoodia Extract does not contain any added caffeine.

    11. Are there any side-effects? There are no known negative side-effects to taking hoodia products.



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    AMINO ACIDS AND PROTEIN
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    Date: June 09, 2005 09:48 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: AMINO ACIDS AND PROTEIN

    Amino Acids

    AMINO ACIDS AND PROTEIN

    Next to water, protein is the most abundant substance in the human body. Complex mega-molecules of protein are the structural building blocks of tissue. The thousands of different proteins in our bodies are composed of 20 molecules called amino acids. In the last 20 years, research has shown the benefits of amino acid supplementation to such diverse areas of human biochemistry as metabolism, enzyme and neurotransmitter production and antioxidant protection. Source Naturals utilizes the latest-breaking research to bring you a highly comprehensive line of amino acid supplements.

    Amino Acids

    DNA provides the instruction manual for life, RNA reads the manual and the genetic information is expressed by proteins. Proteins are the most abundant macromolecules in living cells constituting 50% or more of their dry weight. They create the structure of our cells and tissues, and play an essential role in virtually all of the biochemical events that animate those tissues.

    The term "protein" refers to a set of macromolecules that encompasses an extensive variety of structure and function&endash;from helical rods with the tensile strength of steel to elastic sheets to huge molecular machines with hinged jaws that snap closed to hold other molecules in place. Amazingly, all proteins, in their remarkable variety, are built out of a set of 20 simple molecules called amino acids.

    Amino acids are one of the four types of small molecules out of which all life is constructed. The other three are: palmitic acid (see "Essential Fatty Acids," page #), adenine and glucose. All amino acids share a common chemical "backbone" which consists of an a -carbon atom to which four substituent groups are bonded: a nitrogen-containing amino group (H2N), a carboxyl group (COOH), a hydrogen atom and an "R" group. The "R" group or side chain (figure #) varies in electric charge, size, structure and solubility in water, giving each amino acid its distinct chemical properties. Since all amino acids (except glycine) contain at least one asymmetrical carbon atom, each one exists in at least two forms: the l form and its mirror image or stereoisomer, the d form. While both forms are found in biological systems, only the l form is present in proteins.

    Amino acids are linked together like beads on a string to form proteins, sometimes called peptides because of the peptide bonds that link the amino acids together. They range in size from simple two-amino-acid dipeptides to polypeptides which contain more than 1800 connected amino acids. The chemical backbone of the amino acids and their sequence constitutes the primary structure of a protein. Polypeptide chains then fold into specific 2 and 3-dimensional configurations that are unique for each type of protein. The pattern of folds, along with the chemical nature of the amino acid side chains contained in it, give a protein its characteristic biological activity. For example, the connective tissue proteins collagen and elastin give structure to cellular organelles and tissues, while proteins called enzymes catalyze and facilitate metabolic chemical reactions.

    Nine of the 20 amino acids involved in protein synthesis are considered "essential";they cannot be synthesized by the body and must be obtained from food sources. The term "non-essential" is sometimes used to classify the other eleven amino acids. However, this word is perhaps a misnomer; a better term might be synthesizable. These amino acids are just as vital to human metabolism as the "essential" amino acids; so vital that the body can synthesize them. They are, however, more available, more versatile, and more interchangeable.

    When the presence or absence of a particular amino acid will determine whether a protein can be created or not, that amino acid is called a rate-limiting factor for that protein. For example, the tripeptide glutathione, a compound that forms an important part of the body's protective mechanisms, is made of the amino acids glutamic acid, glycine and cysteine. Glutamic acid and glycine tend to be plentiful in the diet, and can be easily interconverted. Cysteine is the rate-limiting factor for glutathione; the amount of cysteine in the diet will determine the amount of glutathione that can be manufactured by the body.

    Amino acids have a special role to play in brain nutrition, because all neurotransmitters are derived from amino acids or related compounds such as choline. Brain neurotransmitters, specifically, are biochemical keys to the workings of the mind. They are substances that perform chemical transmission of nerve impulses between neurons or between neurons and other cell types such as muscle. They work in the following way: an electric current (or action potential) travels down the length of a neuron, or nerve cell, until it Reaches the synapse - a narrow gap between two cells. The incoming nerve impulse triggers the release of neurotransmitter (NT) molecules, which diffuse across the synaptic gap. The neurotransmitter molecules bind with receptor proteins embedded in the membrane of the post synaptic neuron and activate a physiological response. Excitatory neurotransmitters propagate a new action potential while inhibitory NT's inhibit the development of new action potentials.

    The amino acid precursors of neurotransmitters are able to cross the blood-brain barrier, a structural feature of brain anatomy that prevents many substances from contacting brain tissue. Thus, it is possible to influence brain metabolism (and therefore emotional states) through the mechanism of neurotransmitter synthesis. The enhancement of neurotransmitter production is one of the most exciting advancements to occur in the field of nutrition in modern times.

    A major portion of the amino acid requirement in humans is derived from the proteins in food. Successive proteolytic enzymes attack the peptide bonds, cleaving one amino acid at a time from the polypeptide chain. Ultimately, free amino acids as well as small peptides (especially dipeptides) are absorbed through the mucosal cells of the small intestine. The small peptides are then further hydrolyzed so that only free amino acids enter the liver and portal vein. This sounds like a fairly straightforward process. However, the presence of a particular amino acid profile in a certain food does not guarantee the assimilation of those amino acids when the food is ingested. There are three types of amino acids: acidic, basic and neutral; each of these classes has a different transport mediator. Therefore, there is competition for the carrier between any two amino acids in a certain class, both in the digestive tract and at the blood-brain barrier. Thus, the isolation of "free-form" amino acids is an important aid to nutritional engineering. In many cases, the consumption of high potencies of a particular amino acid allows that nutrient to overwhelm the competition for absorption. The resulting increase in blood and tissue levels will yield the benefits conferred by that nutrient.

    The isolation of free-form amino acids is an important advancement in the field of nutrition science. Amino acid supplements offer a broad range of choices to complement your nutritional program.



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    Heart Science - A Five-Tiered Approach to Heart Health ...
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    Date: June 02, 2005 12:07 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Heart Science - A Five-Tiered Approach to Heart Health ...

    Heart Science 30 tabs

    Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available.

    Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health

    Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for
    1) generating energy,
    2) decreasing harmful homocysteine levels,
    3) fighting oxidized cholesterol,
    4) maintaining the heart’s electrical rhythm, and
    5) protecting artery and capillary linings.

    Energy Generators for An Energetic Organ

    Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply.

    There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently.

    CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10

    Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound.

    Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21

    HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells.

    Homocysteine Regulators

    B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization.

    The Dangers of Oxidized LDL Cholesterol

    While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL.

    When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse.

    The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes.

    Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol.

    Cholesterol Fighters

    Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits:

  • • Beta Carotene, a plant pigment, is the naturally occurring precursor to Vitamin A. When the body takes in high enough amounts of Beta Carotene, this lipid-soluble free radical scavenger concentrates in circulating lipoproteins and atherosclerotic plaques, where it performs its antioxidant functions. Beta Carotene is particularly unique and powerful as an antioxidant because it is capable of trapping a very toxic form of di-oxygen, called singlet oxygen, which can result in severe tissue damage. Beta Carotene is one of the most efficient quenchers of singlet oxygen thus far discovered. Six tablets of HEART SCIENCE provide an unprecedented 45,000 IU of Beta Carotene!
  • • Vitamin C is found in plasma, the watery component of blood, where it functions as a potent antioxidant. In addition to strengthening artery linings through collagen manufacture, Vitamin C is involved in the regeneration of Vitamin E within LDL particles. Vitamin C also plays an important role in the conversion of cholesterol into bile acids by the liver, a crucial step in reducing blood cholesterol levels. Once converted into bile acids, and then into bile salts, cholesterol can be excreted from the body, preventing build-up. Supplementation with Vitamin C may lower levels of LDL cholesterol and increase those of HDL cholesterol.25 It may also have a part in actually removing cholesterol deposits from artery walls — good news for people who are already experiencing plaque buildup.25 Each daily dose of HEART SCIENCE provides 1,500 mg of Vitamin C in its bioactive mineral ascorbate form.
  • • Vitamin E, together with Beta Carotene, protects lipids from free radical attack. It is the major antioxidant vitamin that is carried in the lipid fraction of the LDL particle, where it protects the LDL particle from damaging oxidation. Within an LDL particle, one molecule of Vitamin E has the ability to protect about 200 molecules of polyunsaturated fatty acids from free radical damage! Vitamin E also aids in protecting the heart by interfering with the abnormal clumping of blood cell fragments, called platelets, within blood vessels.4 It has been shown to inhibit the formation of thromboxanes and increase the production of prostacyclins, which together decrease abnormal platelet aggregation.11 A high potency of Vitamin E — 400 IU’s — is included in six tablets of HEART SCIENCE in the natural d-alpha succinate form, recognized by scientific researchers to be the most absorbable form!
  • • Selenium is an important mineral which has only recently gained attention. When incorporated into the enzyme Glutathione Peroxidase, it has highly powerful free radical-scavenging abilities, and has been shown to work synergistically with Vitamins A, C, and E. An essential mineral, Selenium used to be derived from eating foods grown in Selenium-rich soil. However, modern agricultural practices have depleted soil of its natural Selenium content, leaving many Americans deficient in this vital nutrient. Several epidemiological studies show that the incidence of advanced fatty deposits in blood vessels is much greater in individuals living in geographic areas of the United States and other parts of the world where the Selenium content of the soil is very low.27
  • Proanthodyn,™ an extract of grape seeds, is being called the most powerful antioxidant yet discovered. This highly potent, water-soluble bioflavonoid contains between 93-95% proanthocyanidins, the highest concentration of any nutrient available today. The protective actions of proanthocyanidins may help to prevent the development of plaque in artery walls by inhibiting the free radicals which are produced during the oxidation of cholesterol. The optimal daily amount (100 mg) of Proanthodyn is included in six tablets of HEART SCIENCE. In addition to the protective actions of antioxidants, several other nutrients can contribute to healthier cholesterol ratios.
  • • Chromium is a trace mineral which functions to aid the entrance of glucose into cells. Six tablets of HEART SCIENCE provide 300 mcg of Chromium in the form of Chromate® Chromium Polynicotinate and Chromium Picolinate — the most bioactive forms of Chromium. Not many people are familiar with the vital role Copper plays in the body. This trace mineral is found in all tissues of the body, and is particularly concentrated in the heart. Copper is part of several enzymes, and, in this capacity, is necessary for the development and maintenance of the cardiovascular system, including the heart, arteries, and other blood vessels. Because of its role in elastin production, Copper deficiency can severely damage blood vessels and heart tissue. In fact, researchers have found an inverse relationship between Copper status and increased risk for heart damage.10
  • • L-Proline and L-Lysine are two natural amino acids which show exciting promise in helping to prevent fatty deposits in blood vessels. Researchers have recently identified a particle associated with LDL called apoprotein (a) which is believed to be a main culprit in plaque development. 17 Scientific investigation has revealed that the lipoprotein (a) particle has an adhesive quality that makes the lipoprotein fat globule stick inside blood vessels. The sticky fat globules accumulate, leading to fatty deposits in blood vessels and the subsequent clogging of the arteries. L-Proline and L-Lysine tend to form a barrierlike layer around the apoprotein (a) particle, helping to push it away from the blood vessel wall, and impeding deposit.21

    The Regulating Trio

    Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings.

  • • Magnesium is one of the single most important nutrients for maintaining a healthy heart. It plays an extremely vital role in maintaining the electrical and physical integrity of the heart muscle. It has been well established that Magnesium deficiency predisposes humans to serious disruptions of normal cardiac rhythm. One theory is that because Magnesium has a relaxing effect on muscle tissue, inadequate Magnesium stores may make the coronary arteries more susceptible to muscle spasm.10 Too little Magnesium can cause a Calcium/Magnesium imbalance, which can lead to the influx of too much Calcium into heart cells, and potentiate spasms in heart tissue. Another point for consideration is that because it relaxes the blood vessels, Magnesium keeps these vessels open, allowing for maximum blood flow to the heart. Magnesium also has the unique ability to stop unnecessary blood clotting by helping to reduce platelet adhesion.31 Blood clots are naturally produced by the body as a protective device to stop excessive blood flow when the body is injured. The clotting response happens when the body senses that the normally smooth blood vessel linings are rough, indicating that there is a cut. However, sometimes the body mistakes the rough surface of plaque-covered arteries as cuts, and creates unnecessary blood clots. Or, if a high fat meal has just been eaten, tiny fat globules called chylomicrons enter the bloodstream and can cause platelets to become abnormally sticky, possibly creating clots. When these clots flow through the bloodstream and reach a part of the artery which has plaque buildup, normal blood flow is blocked, and the amount of blood which Reaches the heart is severely compromised. Magnesium is also crucial for the entrance of Potassium — a key mineral for many bodily functions — into the cells. Even if the body’s Potassium stores are high, without enough Magnesium, the Potassium will not be able to enter the cells and be utilized by the body. 300 mg of Magnesium (75% of the U.S.RDA) are contained in each daily dose of HEART SCIENCE. Along with Magnesium, Potassium helps to regulate normal heartbeat and blood pressure, and is necessary for the contraction and relaxation of muscle tissue. Potassium and Sodium are present in all body fluids; Potassium is found primarily within cell fluids, while Sodium is usually present in fluids surrounding cells. Together, they function to maintain the normal balance and distribution of fluids throughout the body. The body ideally should have a Potassium/Sodium balance of about 1:1; however, because the body holds onto Sodium, yet eliminates Potassium quickly, it is important that the dietary ratio of these two minerals be at least 3:1. Unfortunately, the typical American diet, with its emphasis on processed, salty (Sodiumrich) foods and lack of fresh fruits and vegetables, severely alters the body’s natural Potassium/ Sodium balance. Diets in the United States are extremely high in Sodium — sometimes containing as much as 15 times the recommended daily intake! A high Sodium/low Potassium diet interferes with the normal regulation of heartbeat and blood pressure, and has been linked with elevated blood pressure.25 Taurine is an amino acid which helps normalize electrical and mechanical activity of the heart muscle by regulating Potassium flux in and out of the heart muscle cells.

    Artery Lining Protectors

    Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6

    Capillary Strengtheners

    Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart.

    Heart Smarts

    The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care.

    Source Naturals HEART SCIENCE™


    The Five Tiered Approach to Heart Health
    Six tablets contain:
    Vitamins and Minerals %USRDA
    Pro-Vit A (Beta Carotene) 45,000 IU 900%
    Vit B1 (Thiamine) 50 mg 3333%
    Vit B3 (Inositol Hexanicotinate) 500 mg 2500%
    Vit B6 (Pyridoxine HCl) 25 mg 1250%
    Coenzyme B6 (Pyridoxal-5-Phosphate)
    25 mg yielding: 16.9 mg of Vit B6 845% (Total Vitamin B6 Activity) (41.9 mg) (2095%)
    Vit B12 (Cyanocobalamin) 500 mcg 8333%
    Folic Acid 800 mcg 200%
    Vit C (Magnesium Ascorbate) 1500 mg 2500%
    Vit E (d-alpha Tocopheryl Succinate) 400 IU 1333%
    Chromium (ChromeMate® †Polynicotinate-150 mcg & Chromium Picolinate††-150 mcg) 300 mcg *
    Copper (Sebacate) 750 mcg 37.5%
    Magnesium (Ascorbate, Taurinate & Oxide) 300 mg 75%
    Potassium (Citrate) 99 mg *
    Selenium (L-Selenomethionine) 200 mcg *
    Silicon (From 400 mg of Horsetail Extract) 13mg *
    * U.S. RDA not established.
    Other Ingredients and Herbs
    Coenzyme Q10 (Ubiquinone) 60 mg
    L-Carnitine (L-Tartrate) 500 mg
    Hawthorn Berry Extract 400 mg
    Proanthodyn™ (Yielding 95 mg of Proanthocyanidins from grape seed extract) 100 mg
    L-Proline 500 mg
    L-Lysine (HCl) 500 mg
    NAG™ (N-Acetyl Glucosamine) 500 mg
    Bromelain (2000 G.D.U. per gram) 1200 G.D.U.
    Taurine (Magnesium Taurinate) 500 mg
    Horsetail Extract (Yielding 31 mg of Silica) 400 mg
    Inositol (Hexanicotinate) 50 mg

    Reference:
    1. Azuma, J., Sawamura, A., & Awata, N. (1992, Jan). “Usefulness of Taurine... and its Prospective Application.” Japanese Circulation Journal, 56(1), 95-9.
    2. Blazso, G and Gabor, M. (1980). “Odema-inhibiting Effect of Procyanidin.” Acta Physiologica Academiae ScientiarumHungaricae, 56(2), 235-240.
    3. Brattstrom, E. L, Hultberg, L. B., & Hardebo, E. J. (1985, Nov.). “Folic Acid Responsive Postmenopausal Homocysteinemia.” Metabolism, (34)11, 1073-1077.
    4. Colette, C., et al., (1988). “Platelet Function in Type I Diabetes: Effects of Supplementation with Large Doses of Vitamin E.” American Journal of Clinical Nutrition, 47, 256-61.
    5. England, M. R., et al. (1992, Nov. 4). “Magnesium Administration and Dysrhythmias...A Placebo-controlled, Double-blind, Randomized Trial.” Journal of the American Medical Association, 268(17), 2395-402.
    6. Felton, G. E. (1980, Nov.). “Fibrinolytic and Antithrombotic Action of Bromelain...” Medical Hypotheses (11)6, 1123-33.
    7. Grundy, S. M. (1993, Apr.). “Oxidized LDL and Atherogenesis: Relation to Risk Factors...” Clinical Cardiology, 16 (4 Suppl.I), I3-5.
    8. Hano, O. et al. (1994, June). “Coenzyme Q10 Enhances Cardiac Functional and Metabolic Recovery and Reduces Ca2+ Overload during Postischemic Reperfusion.” American Journal of Physiology, 266(6 Pt 2), H2174-81.
    9. Heineke, et al. (1972). “Effect of Bromelain (Ananase) on Human Platelet Aggregation.” Experientia V. 23, 844-45.
    10. Hendler, S. S. (1991). The Doctors’ Vitamin and Mineral Encyclopedia. NewYork: Fireside.
    11. Jandak, et al. (1988, Dec. 15). “Reduction of Platelet Adhesiveness by Vitamin E Supplementation in Humans.” Thrombosis Research 49(4), 393-404.
    12. Jialal, I., et al. (1991, Oct. 15). “Beta-Carotene Inhibits the Oxidative Modification of Low-density Lipoprotein.” Biochimica et Biophysica Acta, 1086(1), 134-8.
    13. Jialal, I. & Fuller, C. J. (1993, Apr. 16). “Oxidized LDL and Antioxidants.” Clinical Cardiology, Vol. 16 (Suppl. I), I6-9.
    14. Jialal, I., & Grundy, S.M. (1991, Feb.). “Preservation of the Endogenous Antioxidants in Low Density Lipoprotein...” Journal of Clinical Investigation, 87(2), 597-601.
    15. Kamikawa, T., et al. (1985). “Effects of Coenzyme Q10 on Exercise Tolerance...” American Journal of Cardiology, 56, 247-251.
    16. Kosolcharoen, P., et al. (1981, Nov.). “Improved Exercise Tolerance after Administration of Carnitine.” Current Therapeutic Research, 753-764.
    17. Lawn, R. (1992, June). “Lipoprotein (a) in ...” Medicine, 12-18.
    18. Mortensen, S.A.et al. (1985). “Long-term coenzyme Q10 therapy: A major advance in the management of resistant myocardial failure.” Drugs Exp. Clin. Res., 11(8), 581-93.
    19. Nayler, W. G. (1980). “The Use of Coenzyme Q10 to Protect Ischemic Heart Muscle.” In: Yamamura Y., Folkners K., Ito Y., eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 2, Amsterdam: Elsevier/North-Holland Biochemical Press, 409-425.
    20. Press, R.I., & Geller, J., (1990, Jan.). “The Effect of Chromium Picolinate on Serum Cholesterol and Apolipoprotein Fractions in Human Subjects.” Western Journal of Medicine, 152, 41-45.
    21. Rath, M. (1993). Eradicating Heart Disease. San Francisco: Health Now.
    22. Rossi, C. S., & Silliprandi, N. (1982, Feb.). “Effect of Carnitine on Serum HDL Cholesterol: Report of Two Cases.” Johns Hopkins Medical Journal, 150(2), 51-4.
    23. Schwarz, K. (1977, Feb. 2). “Silicon, Fibre, and Atherosclerosis.” The Lancet, 454-456.
    24. Selhub, J., et al. (1995, Feb. 2). “Association Between Plasma Homocysteine Concentrations and Extracranial Carotid-artery Stenosis.” New England Journal of Medicine, 332(5), 286-291.
    25. Somer, Elizabeth. (1992). The Essential Guide to Vitamins and Minerals. New York: Health Media of America.
    26. Stampfer, M. J., et al. (1992, Aug. 19). “A Prospective Study of Plasma Homocyst(e)ine...” Journal of the American Medical Association, 268(7), 877-881.
    27. Suadicani, P., Hein, H. O., & Gyntelberg, F. (1992, Sept.). “Serum Selenium Concentration...in a Prospective Cohort Study of 3000 Males.” Atherosclerosis, 96(1), 33-42.
    28. Thomas, C. L. (Eds.). (1985). Taber’s Cyclopedic Medical Dictionary, (15th ed.). Philadelphia: F.A. Davis Company.
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    Date: May 12, 2005 09:33 AM
    Author: Darrell Miller (dm@vitanetonline.com)

    Keeping the Intestines Healthy

    "Friendly Bacteria" Therapy Breakthrough

    by Richard Conant, L.Ac., C.N.

    Ninety percent of the cells found in the human body are not of human origin.

    No, this does not mean we are all products of some sinister alien experiment.

    The human body is made up of about 10 trillion cells. This huge number is dwarfed by the bacteria we all carry around in our intestinal tracts. The lower bowel is a campground for roughly 100 trillion bacteria, single-celled plant organisms that can be seen only through a microscope.

    When we enjoy good intestinal health, the bulk of these bacteria are beneficial. Known as "friendly flora," these tiny guests help digest our food by breaking down undigested proteins, fats and carbohydrates. The friendliest of the friendly bacteria are the "lactobacilli," so named because they produce lactic acid in the bowel, by fermenting carbohydrates. This lactic acid production is profoundly important for keep the intestines healthy. And good intestinal health is the foundation of overall health.

    How do we maintain a thriving population of lactic acid-producing bacteria in the gut? First introduced into the human body through mother's milk, lactobacilli are somewhat fragile. Stress, poor diets, and antibiotics can kill them off. They should be replanted fairly regularly throughout life. One way to do this is through consumption of cultured milk products such as sour milk, kefir and yogurt, which contain live lactobacilli. They can also be consumed in dietary supplements, but this may or may not be a reliable route. Bacterial products do not keep very well on the shelf, they require refrigeration, and are largely destroyed on the trip from the mouth to the gut by our own digestive juices.

    Introducing Lactobacillus sporogenes- a revolutionary new friendly bacteria supplement.

    This article will focus on one particular species of lactobacilli, a relatively unknown member of the family called Lactobacillus sporogenes. This lactic-acid producing bacteria may prove to be one of the most practical forms for use in supplements, thanks to a unique property not shared by the more well-known friendly flora such as acidophillus. L. Sporogenes is a spore-forming bacteria. Safely enclosed within a spore coat that protects it from the environment, L. sporogenes is resistant to heat, oxygen and digestive acids. Once L. sporogenes Reaches the intestines, its spore coat dissolves, freeing the bacteria to multiply and churn out the beneficial lactic acid. (The spore coat, made up of a calcium-protein-carbohydrate complex, is harmless).1

    The difficulty of keeping friendly bacteria supplements alive is an ongoing problem for manufacturers of these products. Studies have analyzed various commerical products claiming to contain acidophilus and found they often contain few live bacteria.2,3 L. Sporogenes is naturally microencapsulated; this insulates it from the gauntlet through which friendly bacteria in dietary supplements must pass.1 Autointoxication-Poisoning by Bacterial Toxins The intestinal tract may also play host to pathogenic, or disease-causing bacteria. These "unfriendly flora" cause putrefaction and release injurious toxins into the lower bowel. This healthy picture is all too common, and has long been concern of wholistic health practitioners.

    The concept of "autointoxication," poisoning of the body by intestinal toxins, was popular among doctors in the late 19th and early 20th centuries. An editorial on the dangers of autointoxication which appeared in the June 3, 1893 issue of the Journal of the American Medical Association (JAMA) declared that "most likely a large majority of chronic diseases take their origin from this cause."4 The famous Russian physician Eli Metchnikoff pioneered the use of lactobacteria for preventing autointoxication and restoring bowel health. His landmark work 'Prolongation of Life' sparked interest in lactobacilli as a food supplement.5,6

    Naturopathy, widely practiced during the early twentieth century, has always stressed the fundamental importance of bowel cleansing. With the advent of so-called "scientific medicine," naturopathy slipped into decline, and the concept of autointoxication was discredited. Over the last thirty years or so, this has changed. Naturopathic medicine has rebounded, and the importance of bowel health is once again recognized. A paper published in the New England Journal of Medicine in 1964, while opining that autointoxication "was exploited by quacks and faddists" in the early 1900's concedes that "the concept of autointoxication must now receive serious consideration."7

    Leaders in the rebirth of natural medicine such as Dr. Bernard Jensen have helped educate the public about the importance of keeping the bowels healthy through regular use of lactobacilli. Jensen is well-known for his extensive studies of regions such as the Hunza Valley in Pakistan where people commonly live well over one hundred years. Jensen and others have noted that the consumption of fermented dairy products containing lactobacilli is a common dietary practice in these areas. Their observations have contributed to the popularity of friendly bacteria supplements. At the same time, clinical research has provided ample evidence of the beneficial effects of lactobacteria supplementation.5,9<.sup>

    Eubiosis-Keeping a Healthy Bacteria Population in the Intestinal Tract

    In his book 'Tissue Cleansing Through Bowel Management, which contains a wealth of valuable wisdom on intestinal health, Dr. Jensen writes, "Where health and vitality are found, we invariably find the friendly and beneficial microbes ... To a large extent the flora in the bowel determines the state of health in an individual."8 In a healthy bowel the friendly flora make up the bulk of the bacteria population. The unfriendly, disease-causing organisms are in the minority. The good bacteria keep them firmly under control. This healthy microbial balance in the gut is called "eubiosis."

    Life in our modern industrial society is hardly favorable to eubiosis. Residents of the Hunza Valley lead unhurried lives in a pristine, pollution-free environment. They grow their own food in fertile, nutrient-rich soil, work close to the landÐand consume lactic-acid producing bacteria on a daily basis. For the rest of us who cannot hope to enjoy this enviable lifestyle, eubiosis is something we should never take for granted. This means taking proactive steps to plant the seeds of health in our intestinal garden, by using a viable friendly bacteria supplement.

    Supplements which help to populate the intestinal tract with friendly bacteria are known as "probiotics." The term "probiotic" literally means "for life.' (In contrast, "antibiotic" means "against life.") Probiotics restore the natural state of "eubiosis" that is so very important for health and longevity.

    L. Sporogenes-an ideal probiotic

    Not every species of lactobacilli qualifies as an effective probiotic. As noted above, many do not survive processing, storage and passage through the digestive system very well. The following attributes make L. Sporogenes an ideal probiotic supplement:1,10,11

    1) Naturally microencapsulatedÐstable at room temperature and can be stored unrefrigerated for long periods without loss of viable organisms.

    2) Tolerates heat, stomach acid and bile, allowing it to successfully travel into the lower bowel.

    3) Non-pathogenic, has only beneficial effects on its host. Has similar characteristics as acidophilus: prefers a mild acid environment; produces lactic acid, digestive enzymes, etc.

    4) Readily multiplies in the human gut. In the stomach, the spore coat absorbs moisture and begins to swell. Upon reaching the small intestine, the bacteria cells germinate and begin to multiply, doubling in number every 30 minutes.

    5) Produces enzymes which help digest protein, fats and carbohydrates. These enzymes include lactose, the enzyme that digests milk sugar.12

    6) Creates a favorable environment (mildly acidic) in the gut for other friendly bacteria to thrive. Prevents overgrowth of pathogenic organisms.

    7) Produces lactic acid in the form of L- lactic acid only.

    The last point is especially important. Lactic acid occurs in the form of three isomers (substances with identical molecular structures that have different shapes): L-lactic acid, D-lactic acid and DL-lactic acid. The D form is metabolized slowly, and can produce acidosis in the system. (Infants have a particularly difficult time metabolizing D-lactic acid.)11,13 DL-Lactic acid, the kind acidophilus makes, may be converted to either D or L.

    The L form is the one we want. L. sporogenes is a "homofermenter," it makes L-lactic acid exclusively. Lactic acid keeps the gut mildly acidic. This acidity is essential for the gut to be a hospitable home for friendly bacteria, and stops the growth of the unwelcome disease-causing bacteria.

    L. sporogenes has only one drawback. It is a transient visitor that does not permanently colonize in the digestive tract. A study on the retention of L. sporogenes found no bacteria in the feces six days after consumption was discontinued.14

    L. Sporogenes-Results from Clinical Studies

    L. Sporogenes is used extensively in Japan and approved by the Japanese equivalent of the FDA. L. sporogenes has been given to hospital patients suffering from intestinal complaints such as gas and bloating due to abnormal fermentation, constipation, diarrhea and indigestion. (These problems often occur after surgery or chemotherapy.) A total of 16 clinical reports are on record in Japanese hospitals, documenting 293 case of digestive complaints treated with L. sporogenes.15 The overall improvement rate is an impressive 86 percent. Results are typically seen within four to five days. L. sporogenes has also been used with success to clear up diarrhea in newborns.16 Like other lactobacilli, L. sporogenes lowers blood cholesterol. (Lactobacilli break down cholesterol and bile salts in the intestinal tract.) Researchers at a hospital in New Delhi, India gave L. sporogenes tablets to 20 patients with high cholesterol for twelve weeks.17 Total cholesterol levels were substantially reduced, along with LDL cholesterol, and the beneficial HDL rose slightly.

    The popularity of L. sporogenes in other countries as an ideal friendly bacteria supplement will no doubt be soon matched in the U.S. This microscopic helper for intestinal health is now sold in probiotic products under the name "Lactospore®."

    References

    1. Gandhi, A.B., Nagarathnam, T. Probiotics in veterinary use. Poultry Guide 1990;27(3):43-47.

    2. Brennan, M., Wanismail, B., Ray, B. Prevalence of viable Lactobacillus acidophilus in dried commercial products. Journal of Food Protection 1983;46(10):887-92.

    3. Gilliland, S.E., Speck, M.L. Enumeration and identity of lactobacilli in dietary products. Journal of Food Protection 1977;40(11):760-62.

    4. Dalton, R.H. The limit of human Life, and how to live long. JAMA 1893;20:599-600.

    5. Shahani, K.M., Ayebo, A.D. Role of dietary lactobacilli in gastrointestinal microecology. American Journal of Clinical Nutrition 1980;33:2448-57.

    6. Metchnikoff, E.. Prolongation of Life. New York: G.P. Putnam Sons;1908.

    7. Donaldson, R.M. Normal Bacterial populations of the intestine and their relation to intestinal function. New Eng. J. Med. 1964;270(18):938-45.

    8. Jensen, B. Tissue Cleansing Through Bowel Management. Escondido, CA: publ. by Bernard Jensen, D.C.;1980.

    9. Schauss, A.G. Lactobacillus acidophilus: method of action, clinical application, and toxicity data. Journal of Advancement in Medicine 1990;3(3):163-78.

    10. 'General InformationÐLactospore®' 1996; Sabinsa Corporation: Piscataway, NJ.

    11. Gandhi, A.B. Lactobacillus sporogenes, An Advancement in Lactobacillus Therapy. The Eastern Pharmacist August 1998:41-44.

    12. Kim, Y.M., Lee, J.C., Choi, Y.J., Yang, H.C. Studies on the production of beta galactosidase by lactobacillus sporogenes. Properties and application of beta galactosidase. Korean J. Appl. Microbiol. Bioeng. 1985;13(4):355-60.

    13. Oh, MS. D-Lactic acidosis in a man with short bowel syndrome. New Eng J Med 1979;31(5):249-52.

    14. Hashimo, K. et. al. New Drugs and Clinics 1964;13(9):53-66.

    15. 'Abstracts of papers on the clinical studies of Lacbon' Unpublished data.

    16. Dhongade, R.K., Anjaneyule, R. Lactobacillus sporogenes (Sporlac) in neonatal diarrhea. Unpublished data.

    17. Mohan, J.C., Arora, R., Khaliullah, M. Preliminary observations on effect of Lactobacillus sporogenes on serum lipid levels in hypercholesterolemic patients. Indian J. Med. Res. 1990;92(B):431-32.

    Full Spectrum Multidophilus Probiotic Supplement 12 Strains of acidophilus

    Proprietary Probiotic Blend (Supplying over 20 billion organisms):
  • B. lactis
  • B. bifidum
  • B. infantis
  • B. longum
  • L. acidophilus
  • L. brevis
  • L. bulgaricus
  • L. paracasei
  • L. planatarum
  • L. rhamnosus
  • L. salivarius
  • Streptococcus thermophilus


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