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Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?   
Date:
December 07, 2023 12:12 PM
Did you know that glutathione is not only great for liver health, but it also promotes beautiful, radiant skin?Glutathione (GSH), often considered as an amino acid but actually a tripeptide, is an antioxidant primarily synthesized in the liver. Composed of cysteine, glutamic acid, and glycine, it plays a crucial role in the synthesis and repair of DNA and protein, as well as the synthesis of prostaglandins. With its involvement in various functions like amino acid transport, toxin and carcinogen metabolism, immune system function, prevention of oxidative cell damage, and activation of enzymes, it is undoubtedly the most important tripeptide in the body. While the benefits of supplementing with glutathione are numerous, two particularly compelling reasons are its positive impact on liver health and beautiful skin, which are the key focus of this article. However, before diving into the specifics of liver health and skin benefits, it's important to review the data on glutathione depletion and absorption. GSH depletion can occur due to various oxidative stressors such as radiation, v.infections, enviro toxins, household chemicals, heavy metals, surgery, inflammation, burns, septic shock, and dietary deficiencies of GSH precursors and enzyme cofactors. Additionally, research suggests that GSH levels tend to decline with age. The bioavailability of glutathione as a dietary supplement has encountered challenges in the past. Studies in the 1990s suggested that oral GSH might be inactivated by peptidases in the gut, as the levels of glutathione in the body did not seem to correlate with dietary intake, despite its presence in fruits, vegetables, and meats. Moreover, previous studies showed no significant increase in blood GSH levels when subjects were given high doses of 1,000-3,000 mg. As a result, alternative strategies like supplementation with NAC were used to boost GSH levels. In 2014, something interesting happened that changed the way we look at the bioavailability of GSH. A groundbreaking study published in the Journal of Agricultural and Food Chemistry shed new light on the old research. This study showed that GSH, when taken in its intact form as OPITAC, a yeast-derived glutathione by Kohjin/Mitsubishi, can actually be rapidly transported across intestinal epithelial cells. Once inside, it gets rapidly converted into oxidized glutathione (GSSG) and accumulates in red blood cells and the liver, with only a small presence in plasma. So, although the GSH was indeed absorbed, it didn't show up in blood plasma because it transformed into GSSG and stored in the red blood cells and the liver. The bottom line is, supplementing with GSH is an effective way to boost GSH levels in the body. This finding was further confirmed in another study that described how OPITAC, as a yeast-derived glutathione by Kohjin/Mitsubishi, is directly absorbed in its electrochemically reduced form in the intestine, then transported in the blood in bound forms, and eventually deposited into the liver in its reduced form. But here's where it gets even more significant. A six-month randomized, double-blinded, placebo-controlled trial involving 54 adults was conducted to investigate the effects of oral GSH supplementation (250 or 1,000 mg/day, as OPITAC glutathione, Kohjin/Mitsubishi) on GSH levels in various parts of the body, including blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. The results were astounding. After one, three, and six months, GSH levels in blood increased significantly compared to baseline in both dosage groups. At the six-month mark, GSH levels skyrocketed 30-35 percent in erythrocytes, plasma, and lymphocytes, and a mind-boggling 260 percent in buccal cells in the 1,000 mg group (P < 0.05). Even in the low-dose group, GSH levels in blood and erythrocytes increased by 17 and 29 percent, respectively (P < 0.05). This research clearly demonstrates that supplementation with GSH is not only effective for increasing GSH levels in the body but also for maintaining them. So, to sum it all up, the evidence speaks volumes - supplementing with GSH can have a profound impact on your body's GSH levels, and trust me, that's definitely a good thing! Liver HealthWhen it comes to our well-being, the liver is a true superhero. Let's dive into some fascinating details about this essential organ. Did you know that the liver is not only the largest reservoir of GSH (glutathione) but also a major site of GSH manufacture in the body? Pretty impressive, right? Special cells in the liver work tirelessly to synthesize GSH, which plays a crucial role in detoxification. Speaking of detoxification, the liver is a champion in this field. Its cells have sophisticated mechanisms to break down toxic substances, be it internal or external compounds. During the detoxification process, the liver attaches or conjugates the toxins to water-soluble substances. This attachment makes the toxic molecules more water-soluble, less harmful, and easier to eliminate via urine or bile. In fact, glutathione conjugation produces water-soluble mercaptates that are excreted via the kidneys, effectively detoxifying acetaminophen and nicotine. Isn't it amazing how this process helps our bodies get rid of harmful substances? But that's not all. Adequate levels of glutathione are crucial for the elimination of fat-soluble compounds, particularly heavy metals like mercury and lead. What's more, GSH serves as a cofactor for various peroxidase enzymes, aiding in the detoxification of peroxides generated from oxygen radical attacks on biological molecules. It also assists transhydrogenase enzymes in reducing oxidized centers on DNA, proteins, and other biomolecules. Talk about a multitasker! The practical significance of this liver superhero was demonstrated in a study involving workers exposed to lead. A group of five workers received GSH at 200 mg/day for 30 days, while five others served as the control group. The results were striking. The group receiving GSH showed a significant increase in ALA dehydratase activity (which is inhibited by lead) compared to the control group (p < 0.05). This indicates that GSH could be a valuable solution for treating patients with lead poisoning. So, let's take a moment to appreciate the remarkable liver and its incredible role in maintaining our health and well-being! Alcohol IntoxicationAlcohol consumption is widely recognized for its capability to induce hepatic steatosis, also known as fatty liver disease, and disrupt biomembranes due to hepatic lipid peroxidation. This can lead to various lifestyle-related diseases and even hepatic cirrhosis by diminishing hepatic physiological function. Nevertheless, animal studies have shown that hepatic damage caused by alcohol intoxication can be mitigated by glutathione (GSH), a powerful antioxidant found in cells. To further investigate the impact of GSH supplementation on the effects of alcohol intake, a human crossover comparative study was conducted. The study involved twenty healthy men and women who were grouped into three categories: placebo, 100 mg GSH (as OPITAC glutathione, Kohjin/Mitsubishi), and 30 mg curcumin. The study evaluated laboratory parameters, including breath alcohol concentration at different time intervals (20, 60, 120, and 180 minutes post-alcohol consumption) as measured by an alcohol checker. Additionally, subjective feelings were assessed through a questionnaire. During the study, all participants consumed whiskey in a quantity equal to their body weight multiplied by 1.25 mL, and were instructed to drink the entire sample within 10 minutes. The results revealed that the breath alcohol concentration in the group supplemented with GSH significantly decreased compared to the placebo and curcumin groups at 20 (p<0.01), 60 (p<0.01), 120 (p<0.05), and 180 (p<0.08) minutes post-consumption. Furthermore, the GSH group reported lower levels of "sleepiness," "headache," and "upset stomach" in the subjective feeling questionnaire. Importantly, the concentration of aspartate aminotransferase (AST), an indicator of alcohol-induced organ damage, was significantly lower in the GSH group after two months compared to the placebo group. The oral intake of GSH has demonstrated its effectiveness in reducing alcohol consumption-related stress and improving long-term hepatic function. These findings highlight the potential benefits of GSH supplementation in alleviating the detrimental effects of alcohol intoxication on the liver. Nonalcoholic fatty liver diseaseNonalcoholic fatty liver disease (NAFLD) is a condition characterized by the build-up of fat in the liver of individuals who consume little or no alcohol. Unfortunately, NAFLD is quite common, affecting nearly one-third of all American adults. Interestingly, it often presents without readily apparent signs or symptoms, sometimes resulting in complications, and can lead to liver inflammation and scarring as the fat accumulates. Additionally, NAFLD is typically associated with conditions such as insulin resistance, central obesity, reduced glucose tolerance, type-2 diabetes, and elevated triglyceride levels. Recognizing the substantial role glutathione (GSH) plays in phase 2 liver detoxification, a pilot trial was conducted to examine the therapeutic effects of GSH supplementation in patients with NAFLD. The trial included 29 individuals, and the patients were provided with daily oral supplementation of GSH at a dose of 300 mg (in the form of OPITAC glutathione, from Kohjin/Mitsubishi). The patients' clinical parameters were assessed before and after the GSH supplementation, and liver fat and fibrosis were quantified as well. The primary goal of the study was to determine any changes in alanine aminotransferase (ALT) levels. The results indicated a significant decrease in ALT levels following the GSH supplementation. Furthermore, triglycerides, non-esterified fatty acids, and ferritin levels also showed a reduction. This pilot study provides promising evidence for the potential therapeutic effects of oral glutathione administration, even at practical doses, in patients diagnosed with NAFLD. However, further investigation through large-scale clinical trials is necessary to validate its efficacy. In summary, NAFLD is a prevalent condition with potential serious consequences, but studies like the aforementioned pilot trial shed light on potential treatment options such as GSH supplementation. The findings demonstrate the need for continued research in order to provide more conclusive evidence and expand our understanding of NAFLD management. Beautiful SkinBy activating melanocytes in the skin, there is a notable increase in melanin formation, resulting in various blemishes such as freckles, pigmentation, and UV-induced skin spots, commonly known as age spots or liver spots. This is especially prominent after prolonged sun exposure and tanning. Age spots appear when melanin becomes concentrated or "clumped" in areas that have had years of frequent sun exposure. Luckily, there are materials like glutathione that can prevent or improve such pigmentation-related skin conditions. Another aspect to consider is skin pigmentation, wrinkles, and pores. In a study conducted with eight women in their 30s or early 40s, each supplemented with 100 mg/day of GSH (as OPITAC glutathione, Kohjin/Mitsubishi) for two months, their skin conditions were evaluated using the Robo Skin Analyzer. Several parameters were analyzed, including skin brightness, the amount and area of skin pigmentation, number of pores, and number of wrinkles under the eyes. It was observed that all subjects' skin brightness improved when measured on the second day of the study. Additionally, over the course of the two months, both the amount and area of skin pigmentation decreased, leading to an improvement in blemishes and pigmentation. Not only did glutathione exhibit a whitening effect, but it also reduced the number of wrinkles under the eyes and minimized pores. Furthermore, a randomized, double-blind, two-arm, placebo-controlled study was conducted with 60 otherwise healthy medical students. The purpose was to investigate whether supplementing with 500 mg of glutathione daily for four weeks would affect the skin melanin index compared to a placebo. Melanin indices were measured at six different sites on the body. The results demonstrated that melanin indices consistently decreased at all six sites in subjects who received glutathione after four weeks. The reductions were statistically significant compared to those who received the placebo at two sites: the right side of the face and the sun-exposed left forearm (p = 0.021 and 0.036, respectively). This improvement was likewise reflected in the reduction of UV spots. Importantly, both glutathione and placebo were well-tolerated. In conclusion, oral administration of glutathione leads to a lightening of skin color in the tested subjects. Skin LighteningSkin lightening is a process that is of interest to many individuals who seek to achieve a more even and radiant complexion. In recent studies, the use of a lozenge containing GSH 500 mg was explored as a means of skin lightening through an open-label, single-arm trial. The focus of this trial was to evaluate the buccal mucosa as a route for GSH administration and its potential in relation to skin lightening. It is worth noting that substances absorbed through the buccal route have the advantage of entering directly into the systemic circulation, effectively bypassing the gastrointestinal tract. The trial involved thirty Filipino females with Fitzpatrick skin types IV or V who received a daily glutathione-containing lozenge for eight weeks. The results from this trial demonstrated a significant decrease in melanin indices from baseline to endpoint. What is fascinating is that this visible change became evident in as little as two weeks. It is important to highlight that during this trial, there were no recorded serious adverse events, and the laboratory examination findings remained normal. Based on these findings, the researchers concluded that the lozenge containing glutathione was deemed safe and effective in lightening the skin of Filipino women. In addition to the aforementioned buccal route administration, another interesting approach that emerged from the studies is the topical application of GSH. A double-blind randomized clinical trial35 conducted in Yogyakarta, Indonesia, involved 74 healthy Indonesian women, with an average age of 33.3 ± 5.9 years, to explore the potential benefits of topical GSH. The trial subjects received supervised applications of facial wash twice a day, along with day cream containing sunscreen and night cream. The subjects were divided into three groups based on the active ingredients of the tested products, which included GSH (as OPITAC glutathione, Kohjin/Mitsubishi) at concentrations of 0.1 percent and 0.5 percent, and a control group without GSH. Throughout the trial, the effects of the tested products on skin color and pigmentation were measured using colorimetry with Chromameter Minolta for L. Compared to the baseline measurements, there were significant increases in lightness (L) detected as early as week 2 for the group using GSH at 0.1 percent concentration. Interestingly, this increase was significantly higher compared to the group using GSH at the higher concentration of 0.5 percent, as well as the group without GSH. It is important to note that hyperpigmented lesions also showed improvement, particularly in the group using GSH at 0.5 percent concentration, which displayed superiority compared to the other groups at week 8. In conclusion, the skin care products containing GSH at 0.1 percent and 0.5 percent concentrations were found to be effective in lightening facial skin. The findings from these studies shed light on the potential benefits of GSH in achieving skin lightening, either through buccal administration or topical application. It is worth noting that these studies focused on specific populations and more research is necessary to explore its effectiveness and safety across different skin types and ethnicities. In summary, the administration of
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6592) Hibiscus extracts can be used to provide natural food coloring WITH health benefits 
Date:
March 28, 2018 09:17 AM
While the hibiscus is known as a very ornamental bloom, gracing many gardens, it has an economic role to play as well, serving as a product of high significance in both the food and cosmetic industries. This dual nature of the plant arises from the fact that the hibiscus is both highly nutritious and also the source of a safe coloring agent that can be used even in foods. The periodical, 'Food Science and Human WellnessWellness', explored the viability of hibiscus-generated food coloring for cupcakes and found the resulting product to be both cost-effective and 'clean, ' with the added benefit of adding necessary flavonoids into the human diet. These anthocyanins, aside from the nourishment they provide, appear to be linked with the easing of numerous health complaints, including, hypertension, inflammatory conditions, coughing and excess weight. Key Takeaways:
"Extracts from hibiscus calyces could be used as a natural food coloring, which can provide health benefits at the same time, according to a study published in the journal Food Science and Human Wellness." Read more: https://www.naturalnews.com/2018-03-26-hibiscus-extracts-can-be-used-to-provide-natural-food-coloring-with-health-benefits.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5565) Research pilot explores industrial hemp
Date:
September 07, 2017 12:14 PM
Although the Washington state legislature has allowed hemp to once again be grown in the state, there are still some questions and uncertainties about growing the product. For now, those growing hemp are doing it for research purposes to monitor what the future growers will need it to do in order to create an industrial hemp harvest. Despite the four different types of licenses being granted, there is still some caution because of the plants close relationship it to marijuana. Hopefully some restrictions will change and beneficial aspects of the hemp can be produced, such as CBD oil. Key Takeaways:
"Hector Castro, Olympia-based communications director for the WSDA, says although the program is new, it’s generated a lot of interest from farmers and others who see potential in harvesting hemp." Read more: https://www.spokanejournal.com/local-news/research-pilot-explores-industrial-hemp/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5234) The Science Of CBD Oil [Infographic]
Date:
August 17, 2017 04:14 PM
Cannabis is a booming business right now. Colorado was a state that legalized marijuana back in 2012 and the revenue generated from legal marijuana sales has grown so much that it is now a rival of the GDP of a few island nations. The medical cannabis industry is is one of the major sectors being developed right now. People have known about the benefits for decades and only now are these claims being researched and understood better. Key Takeaways:
"So far CBD oil has been found to treat addiction, inflammation, Multiple Sclerosis, epilepsy, mad cow disease, acne, diabetes, fibromyalgia, insomnia, PTSD, schizophrenia, Crohn’s disease, and many others." Read more: http://www.valuewalk.com/2017/08/cbd-oil/
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5139) Why Everything We Know About Salt May Be Wrong
Date:
May 14, 2017 06:44 AM
Salt and it's effects on the body were recently studied on Russian cosmonauts. They found that the more salt the cosmonauts ate, the less thirsty they were but they became hungrier. This contradicts opinions that salt intake makes you thirstiest. It was also discovered that eating more salt caused increase in urine volume but blood concentrations so salt remained the same no matter how much was eaten. Likely, the body generated the water that was secreted to account for urine volume. It's possible this can lead to weight loss as it was observed in mice in high salt diets in a separate study. Read more: Why Everything We Know About Salt May Be Wrong
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4610) 8 PARTS OF THE BODY THAT ARE INJURED DUE TO YOUR EXCESS STRESS!
Date:
March 05, 2017 03:59 AM
The modern life may provide comforts, but it can also attribute to tons of stress that come with it. There are many things that can cause stress, and many Americans state that they cannot sleep due to an excess amount of stress each night. This can wreak havoc on your body, and you need to make sure you limit your stress. A good diet, and proper rest can play and important role in making sure you limit this stress. https://www.youtube.com/watch?v=HzoIU_O5THc&rel=0Key Takeaways:
"A recent study by the American Psychological Association (APA) has shown that 40% of the adult population has trouble sleeping due to excessive stress.A recent study by the American Psychological Association (APA) has shown that 40% of the adult population has trouble sleeping due to excessive stress."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4073) Fructose is generated in the human brain
Date:
February 24, 2017 10:59 AM
Fructose has been labeled as one of the sugars to avoid when selecting food at the store. However, a recent study out of Yale has shown that the brain can produce fructose from any sugar that is ingested. Some sugar is fine for a diet, but avoiding fructose will not keep your body free of the chemical. This leads to risk of high blood sugar and other health issues. The study may affect many diets and the understanding of obesity. Fructose is generated in the human brain
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4008) Why high-dose vitamin C kills cancer cells
Date:
January 22, 2017 02:59 PM
High doses of vitamin c can kill cancer cells. In the past cancer therapy through vitamin c has not always proven that effective. However, that is because they were trying to get people to ingest it through the mouth. the key is to let hit the bloodstream immediately. The Vitamin C selectively kills the cancerous cells and not the normal cells. This is because normal cells are smarter and handle the hydrogen peroxide better. Key Takeaways:
"Normal cells have several ways to remove hydrogen peroxide, keeping it at very low levels so it does not cause damage. The new study shows that an enzyme called catalase is the central route for removing hydrogen peroxide generated by decomposing vitamin C." Reference: https://www.sciencedaily.com/releases/2017/01/170109134014.htm
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3816) A metabolic switch to turn off obesity
Date:
November 01, 2016 04:04 PM
Here’s some good news to cheer you up. If you’ve been fighting a losing battle trying to lose weight, maybe you should quit beating yourself up about it. A new University of Montreal study of mice says when an enzyme is blocked in some neurons in the mouse brain, it becomes impossible for the mice to lose weight even when they stick to an ideal regime. So now you can blame it all on the ABHD6 enzyme. Key Takeaways:
"A research team at the University of Montreal Hospital Research Centre (CRCHUM) has generated genetically engineered mice, deprived of the ABHD6 enzyme in a localized area of the brain, namely in a specific population of hypothalamic neurons." Reference: https://www.sciencedaily.com/releases/2016/10/161027115843.htm
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3368) How Hyaluronic Acid Benefits The Skin
Date:
May 20, 2014 09:19 AM
Hyaluronic corrosive is found in a great deal of hostile to maturing items. It helps your skin by enhancing the tone and composition. It is discovered characteristically in the body and serves to grease up specific territories. Regularly Occurring Your skin produces hyaluronic corrosive regularly. This happens in the deeper layers and keeps the skin stout and smooth. As we get more seasoned, our body thinks that it is hard to hold dampness so the skin starts to lose its tone and suppleness. Without sufficient dampness, the skin is inclined to hang and as it loses flexibility, wrinkles and scarcely discernible differences show up. Hyaluronic Acid's Function This corrosive functions as against maturing element by helping your body to transform collagen. Collagen is an exceptionally imperative connective tissue found in the skin, which helps it to keep its structure. Surveys Hydroxatone has indicated that including this as a segment the skin gets back its sound shine and energy. Hyaluronic corrosive additionally helps the skin to repair itself from natural harm, for instance the climate or airborne poisons. Audits Hydroxatone has indicated that this cream works well in light of the fact that the Hyaluronic corrosive can infiltrate profound into the skin. Notwithstanding decreasing wrinkles, it has been indicated to support with skin aggravation and in lessening pimple inflamation scars. Superior to Botox There is other mainstream approaches to lessen wrinkles, for example, Botox or plastic surgery. Then again, the principle issue with these systems is, separated from being considerably more exorbitant; they are extremely equivocal on the body and can have awful reactions. Hyaluronic corrosive is not dangerous: it is even generated regularly by the body. It is much less expensive to utilize and has not been indicated to have any significant symptoms. Likewise, dissimilar to Botox infusions, creams holding this corrosive might be utilized anywhere on the face. Hydration Properties Hyaluronic corrosive can hydrate the skin successfully. Truth be told, it can hold 100 times its weight in water. One reason for wrinkles is skin dryness, so by holding more dampness in your skin, you can diminish the appearance of wrinkles as well as keep more from showing up. Hyaluronic corrosive works successfully in against maturing. A substance discovered regularly in the body, it could infiltrate profound into the skin and serves to hold dampness. A cream holding this corrosive is a much more secure strategy than surgery and its belongings are longer enduring.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3123) Things to Know Before Using Arnica Cream for Pain Relief or Bruise Treatment
Date:
April 26, 2014 09:36 PM
The medicinal qualities of Arnica, or scientifically Arnica Montana, are known since long. This is a plant indigenous to Northern Europe. This herbal medicine is widely used as pain reliever. Rich in antioxidants. Arnica contains high amount of flavonoids such as carotenoids, tannins and inulin. It helps to alleviate pains of arthritis, bruises and injuries in short period of time. Since it has some dominant side effects, it is recommended that arnica should be taken under prescription of medics. However, arnica cream is available for common usage. Healing qualities of arnica ointment:
Uses of Arnica
Things to Consider
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3104) Can Hyaluronic Acid Cream Help Improve Skin Health?
Date:
March 16, 2014 04:22 PM
Skin health
Can Hyaluronic Acid Cream Help Improve Skin Health? A question in everybody’s mind at the moment The answer to that question is a resounding yes, and here are reasons why this is so. Hyaluric acid This is a naturally occurring acid that exists in our body. It is a component of the connective tissue that helps in strengthening various parts of our body, including blood vessels, cartilage, and definitely the skin. It helps the skin remain hydrated Research shows that as we get older, the hyaluronic acid quantity in the skin diminishes, leading to a dry skin. Hyaluronic Acid Cream This is a skincare product that has been designed with the same properties as the natural hyaluronic acid that exists in our body. The cream, when applied will deeply penetrate your skin membrane helps the cells take in and retain moisture. This will eventually give your skin a supple and soft appearance that was wearing out. All in all hyaluronic acid cream has proved to be an effective skin care product that will hydrate and plump drying and aging skin. Through research, this product is known to have been formulated with cosmetic-grade hyaluronic acid. Although to some people the name may paint a picture of a harsh erosive product that might do harm to ones skin, hyaluronic acid is tremendously gentle and nourishing to the skin. Apparently it proves to be so tender that it is even recommended for the sensitive skin. In conclusion Hyaluronic acid cream can help improve skin health. Sources
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3064) Is Cocoa Butter Good For The Skin? Why?
Date:
March 06, 2014 03:27 PM
Cocoa butter
Reasons to why cocoa butter is good for your skin: Powdered cocoa butter contains a lot of diverse antioxidants which behave synergistically presenting a massive bothersome resistant to the cost-free radicals which eliminate your skin layer cells along with lead to quick getting older. Therefore, therefore, is it doesn't suitable natural skin care solution. Let's have a look at which record again. Precisely why your 'ideal' natural skin care solution? In order to solution which question, we need to have a look at precisely what antioxidants tend to be, along with precisely what hot cocoa butter can perform them, along with after that the reason why it is advisable than additional natural skin care merchandise on the market. Totally free radicals tend to be small substances kinds in the body's fat burning capacity while vitality is generated coming from blood sugar in the mitochondria of each and every cell phone within your body. Fortunately they are shaped simply by experience of toxins including pesticides, along with particularly the several poisonous pieces of cigarette light up. Cigars along with water lines tend to be believe it or not harmful than tobacco, along with filtration system guidelines make not any difference towards the production connected with cost-free radicals. What exactly that they do is always to eliminate cells, when they're pores and skin cells you continue to grow older. Your skin layer wrinkles along with dries up, and you begin to take on the style connected with an individual many years over the age of you're. These people try this by way of a procedure often known as oxidation, along with antioxidants can certainly keep the idea. These people reduce the effects of your cost-free radicals, and forestall your skin layer cells coming from getting ruined. Contents of cocoa Powdered cocoa butter contains several different antioxidants that can eliminate away from numerous diverse cost-free radicals along with superoxides, as well as hydrogen peroxide. Vitamin e is really a powerful antioxidant -- your strongest of all the so-called antioxidant vitamin supplements in fact, and will quickly eliminate away from hydrogen peroxide along with any oxidizing agent. Others tend to be vitamin supplements A new along with G, however they can not strategy the potency of vitamin E. Furthermore, it contains phytochemicals (posh title pertaining to place chemicals) including flavanoids which might be also powerful antioxidants. Polyphenols are very effective in neutralizing cost-free radicals, and the hot chocolate mass polyphenols tend to be in particular successful. In fact, hot chocolate butter boasts a greater antioxidant awareness and then possibly blueberries as well as other so-called superfoods. In order that hot cocoa butter to work, it will email numerous of the pores and skin cells as is possible, that involves do away with the idea properly directly into your skin layer. The epidermis is incredibly absorbent all of which will eliminate cost-free radicals in the reduced absolute depths of the pores and skin as soon as they're created, along with ahead of they are able to do injury. It is clinically demonstrated which hot chocolate butter will certainly keep pores and skin degradation a result of the harmful consequences from the UV light in the rays of the sun -- UV rays builds cost-free radicals which are very effective in doing damage to pores and skin. Merely go through the influence connected with sunburn! However, there is additional in order to hot chocolate butter than which. It contains a substantial percentage connected with vitamins as well as lime scale, potassium, magnesium, zinc, manganese, copper along with metal, all of which come in a highly bioavailable style which make them far better which business vitamins. Not just that, though. Furthermore, it contains tryptophan, involved in the development connected with serotonin, your 'feel good' neurotransmitter, and also dopamine along with phenylethylamine, many beneficial materials. It is a mental faculties food as well as food to your pores and skin.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3049) Benefits of herb chaste berry for women
Date:
January 17, 2014 08:20 AM
Premenstrual syndrome impacts over 70% to 90% of ladies before menopause in the US and less for ladies in Southeast Asia in light of their contrast in living style and social structure. The event of premenstrual syndrome (PMS) have more than multiplied in the course of recent years because of the acknowledgement of it as a therapeutic condition that is initiated by bad eating methodology with high in soaked sustenance. Premenstrual syndrome is characterized as flawed capacity of the ovaries identified with the ladies' menstrual cycle, it impacts a ladies' physical and enthusiastic state, and frequently meddles with every day exercises as an aftereffect of hormone change. The syndrome happens one to two prior week’s monthly cycle and after that decays when the period begins. In this article, we will talk about how standing berry tree impacts ladies with PMS. Chaste Berry I. Definition Chaste berry tree is an exceptionally significant herb; it has been utilized as drug since old Greek for menstrual issue incorporating absence of ovulation. Today the herb is well known for treating side effects of hormone lopsidedness. II. How chaste berry tree impacts ladies with premenstrual syndrome it hard to accept that chaste beery tree holds no plant estrogen yet has been adequately utilized within treating premenstrual syndrome due to the accompanying lands 1. Iridoid Chaste beery tree holds iridoid incorporating aucubin and agnuside which are frequently intermediates in the bio combination of alkaloid. It serves to enhance invulnerable framework battling against irritation and serves to avoid muscle spam bringing about decreasing menstrual ache and spasms. 2. Androstenedione is the normal antecedent of male and female sex hormone generated by adrenal organ, chaste berry tree holds androstenedione which not just serves to tie the levels of terrible estrogen additionally equalize the levels of testosterone in the ladies figure bringing about decreasing the male example for some ladies with PMS. 3. Key oil Chaste berry tree holds cineol, pinene, castine and different substances, it serves to unwind the apprehensive framework and muscle that serves to diminish side effects of anxious pressure, for example, tension discouragement, menstrual agony and spasms brought about by over animated uterus muscle. It likewise serves to expand liver capacity for overall health. 4. Alkaloid As and alkaloid, it serves to diminish the manifestations of breast delicacy and bosom ache brought about over preparation of prolaction prior and then afterward ovulation. 5. Progesterone The chaste berry tree serves to repress if the levels of progesterone in the event that it is excessively high or raise the levels of progesterone in the event that it is excessively low, in this way, diminishing the danger of hormone awkwardness between estrogen and progesterone.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2969) Boost Energy With CoQ10 And L-Carnitine
Date:
November 21, 2013 08:43 PM
CoQ10 and L-Carnatine
CoQ10 Energy Boost CoQ10 is a vital nutritional element found in all body cells, in particular the mitochondria, in which most energy is generated. The major function of this coenzyme is to assist in the process of oxygen and food conversion into energy. As people grow older their ability to naturally, to produce this coenzyme decays. At the same time as Coenzyme Q10 is taking part in the production of energy in each cell of your body, it is considered be remarkably imperative for the high energy requirements of the heart. The heart needs vast energy amounts, because it is the hardest worker in your entire body. Coenzyme Q10 seems to be indispensable for this process. It offers you sufficient antioxidant provision, protecting the body cells from damage of the free radicals, and proffering a dynamic function of the immune system. L-Carnitine Energy Boost L-Carnitine transports indispensable fat acids into the same organ where CoQ10 plays its major function - the mitochondria. There, with the help of L-Carnitine, all fatty acids are turned into energy. However, the beneficial function of L-Carnitine does not end here. In addition, it also supports the transportation of toxins outside the body. You can think of the problems that might occur if these vital body processes are not fully operational. At the same time however, the major impact of L-Carnitine over the body is directed towards the brain:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2900) Benefits of Extended Release Guggulipid
Date:
January 03, 2013 04:10 PM
Guggul is one of the holistic ancient herbal extracts derived from the Commiphora wightii plant that had been predominant in India although some parts of northern Africa and Asia still had some traces of the same. Over the years, Guggul resin gum derived from the plant has been used to promote a healthy living, and has a good number of recent scientific research findings to back it up. Some of the health benefits associated with the use of Guggulipids supplements (also known as the Guggulsterone Supplements) include lowering of Low Density Lipoproteins (Bad Cholesterol), reducing inflammation, and significantly lowering the risk of suffering from cardiovascular diseases, tumors and cancers. Research: Extensive scientific research shows that Guggulipids play an important role in inhibition of its synthesis in the liver and its hydrolysis into bile salts. It also acts on the thyroid gland which in turn controls the Basal Metabolic Rate that directly relates to the rate of cholesterol catabolism in the body. Additionally, a cascade of reactions in the liver during the process of cholesterol hydrolysis down-regulates the uptake of cholesterol in the gut which ensures that the body is at a healthy blood cholesterol level. Anti-Inflammatory: The anti-inflammatory, anti-tumor and anti-cancer effects are highly associated with the stimulation of the liver to release C-Reactive Protein. Even though the CRP protein is primarily produced by the body in response to inflammation and cell death, presence of the CRP in the blood stream prior to an acute inflammation or cell death plays an important role in toning down inflammatory conditions such as rheumatoid inflammation as well as killing abnormal cells before they develop into tumors and cancerous cells. However, Guggulsterones are rapidly regenerated in the body in the same rate that other steroid hormones are degenerated which makes the use of extended release Guggulipid supplements very essential. This makes it possible to have the body under constant supply of the component for optimal guggulsterone health benefits.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2801) Black pepper extract - Bioperine
Date:
December 21, 2012 01:52 PM
Perhaps the biggest question that goes through our mind on the mention of the phrase black pepper extract is what the benefit of black pepper extracts is. Piperine is the active ingredient of black pepper extract. Used together with other natural nutritional supplements, Piperine not only enhances absorption but also bioavailability. Going back to history, black pepper helped a great deal in shaping the development of the modern world medicine. Ayurvedic medicine that dates back to 6,000BC, used this extract to enhance digestibility. The internal heat generated by consumption of the pepper positively influences the ability of the body to absorb nutrients. As a matter of fact the one's nutritional status is not only dependent on what one eats but in his or her ability to absorb as well as transform nutrients into forms that are usable by the body. For maximum benefits it is important that Black pepper extract (Piperine) is taken a couple of hours after meal.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2766) Can Melatonin Help Me Sleep?
Date:
December 20, 2012 12:22 PM
What is melatonin? Melatonin can be described as a hormone generated in the pineal gland found in the brain. It controls the body circadian rhythms such as sleep-wake cycle. The levels of melatonin in the blood increase before you fall asleep due to darkness (Lack of sunshine). Where to find melatonin Melatonin occurs naturally in humans and plants. Natural melatonin quantity produced decrease with age. Older people produce very little quantities of it. Current Sources It is a synthetic medication that is produced in the laboratories. It is available in pill or liquid forms. The pills can be put in the cheek, underneath the tongue or swallowed. This permits direct absorption in the body. Melatonin supplements are available in health food shops. Food Sources It is also found in foods, in small quantities, such as milk, chicken meat, turkey, and peanuts but in small quantities. Melatonin and sleep Melatonin does not work for every kind of insomnia or sleeping disorders. Your body needs to be ready for sleep for melatonin to be effective. It is safe to use melatonin supplements in low doses long term. Melatonin treats insomnia, autism in children, and as a sleep reliever after withdrawal from benzodiazepine drugs use. It is also very significant for changing sleep/wake patterns for people who work schedules changes regularly. It can also be used to calm individuals before anesthesia is administered for surgery purposes. The body has an internal clock that regulates sleeping cycle and waking hours. The body clock regulates the amount of melatonin produced each day. Melatonin production is affected by light.
For effective treatment of cycle sleep, make sure you take the supplements at the appropriate time of the day (Night time). Use the right method and dosage for it to be helpful. Consuming the sleep supplement at the inappropriate time of the day can lead to biological clock reset. It is essential to understand the right quantity, time of taking and its effectiveness. Taking 1-10mg of melatonin every day restores the pace in people experiencing insomnia synchronizing them to duration of 1day. Melatonin helps enhance sleep. It enhances sleepiness feeling and can intensify the duration of sleep. This supplement has been applied successfully for improving sleep in healthy people and also decreasing jet lag feeling during travels. Remember to consult a physician if you are experiencing sleep issues. Give melatonin a try start with lower doses like 1 mg before bed time and gradually increase till it becomes effective.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2757) Health Benefits Of Liquid Vitamin C
Date:
November 21, 2012 04:15 PM
Vitamin C is one of the most important body nutritional supplements that play an important role in the body. Vitamin C has a lot of benefits to the body and has many immediate effects when taken mostly in liquid form. They are also known as antioxidants that are mainly known to help in clearing off the harmful free radicals that are responsible for gradual cell damages. Liquid vitamin C also assists in the immune system hence warding off possible infections. This also ensures that wounds and damaged tissues are speedily healed; vitamin C also ensures that collagen formation is taking place as well as fat metabolism and iron absorption. In most cases, vitamin C cannot be bodily generated and due to different body functions some people may need greater doses of these vitamins. Liquid vitamin C is known to be efficient in delivering the vitamin into the body's system and is more absorbed when in liquid form. For people who require high doses of vitamin C, vitamin supplementation is however recommended for such people so as to ensure that their body systems are well supplied with vitamins and are strong enough to fight infections. Vitamin C deficiency in adults is very common since many people fail to realize the importance of taking these vitamins and they lack enough vitamins in the body which leads to prone infections such as colds, gum damages and poor wound healing. There are no critical risks when it comes to liquid vitamin C overdose especially for those people who require vitamins at large volumes. Under normal circumstances, rare cases of headaches, fatigue, diarrhea, nausea and vomiting may be experienced when an individual overdoses. Using the products as directed will provide great health benefits. Try it today and feel the difference.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2729) What Are The Health Benefits Of Rhodiola?
Date:
March 16, 2012 08:25 AM
Benefits and Ingredients of Rhodiola Rhodiola is a plant that can be found in the cold regions. Usually, this plant is growing in the Arctic region of eastern Siberia, the Rocky Mountains, the mountains in Central Asia and several mountains in Europe. Rhodiola is included in the Crassulaceae family in which it stores water in its succulent leaves. For European and Asian people, it has been a traditional plan with several benefits. For Russian, it has been consumed as an energy booster for centuries. In Russia, it has been a supplement for athletes, herbalists, physicians, and cosmonauts, which have a function to boost the physical and mental performance. Adaptogen Rhodiola is also popular as a potent adaptogen. Adaptogens have been known as natural plant substances in which their function is increasing the body's non specific resistance. On the other hand, they will normalize the function of the body too. It is very useful to consume them or Rhodiola when the stress occurs. A degree of generalized adaptation will be generated. As the result, the physiology handles the stressful situation in a resourceful manner. Besides, this plant can be used as a therapy in aesthenic condition. It is a condition in which one's work performance declines. In addition, he or she will have poor appetite and also sleep disturbances. Sometimes, muscle will get trouble especially for those who like doing workout. Unfortunately, the problem might take long time. In this case, they have to wait patiently. For the time being, the recovery process can be shortened using Rhodiola. Studies have been reported that consuming this plant is able to make the muscle recovery process faster. It is because of its function to increase the level of RNA, enzymes, and proteins, which are very crucial to muscle recovery. Therefore, it is well recommended to consume Rhodiola after exhaustive workout. Concentration and Memory This plant becomes useful for students since the studies have been held to gain information, whether it influences the brain. From the studies, it has been known that this plant is able to enhance concentration and memorization. Rhodiola has a function to increase the brain's bioelectrical activity which makes the memory energy increase. A study has proven this fact by conducting the research to forty students. They have been given 50 mg of Rhodiola twice a day for 20 days. As the result, those students who consume it have significant improvement in mental performance, physical fitness and psychomotor function. Besides, they also get significant enhancement in their subject mark because they get more motivation to study. Other benefits Another benefit is to protect and stimulate the immune system since Rhodiola reinstates homeostasis or metabolic balance in the body. On the other hand, it also boosts the natural killer cells in the spleen and the stomach. Having known the benefits which can be taken from this plant, people might have the desire to know the ingredients of this plant. There are several ingredients found in this plant such as the class of rosavins including rosavin, rosin and rosarin. Another ingredient is salidrosides. It has been reported that rosavin and salidrosides become Rhodiola ingredients which is responsible for anxiolytic and antidepressant actions.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2613) Stay Young-Looking with PABA
Date:
May 23, 2011 03:44 PM
Most people have not heard of PABA, short for para-aminobenzoic acid. It has often been referred as Vitamin Bx and a member of the B vitamin complex, but this is wrong because it is not an essential, nutrient: life can go on satisfactorily without it, so it is not a vitamin. It is an intermediate in the biosynthesis of folate by bacteria. Since folate cannot be produced naturally by human metabolism it has either to be taken in the diet or synthesized by colonic bacteria such as E. coli using PABA as an intermediate. However, humans can get folate, the natural form of folic acid, from their diet, so PABA is not essential and hence not the vitamin that some claim it to be. Nevertheless, it is useful, and apart from its application in sunscreens as a UV filter, PABA is a powerful antioxidant and can neutralize the free radicals and free roaming electrons that are believed to be the cause of aging. A supplement of PABA can destroy free radicals as soon as they are generated by your metabolism and atmospheric pollution and prevent the cell damage they cause. It is this cell damage that gives the appearance of aging: wrinkled skin, age or liver spots and a tough leathery appearance. By taking a regular supplement of PABA you can go a long way towards avoiding this and retaining your youthful appearance for a lot longer.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2302) Five Tips for Healthy Bones and Teeth
Date:
May 19, 2011 03:36 PM
1. Take calcium in your diet: dairy products, green vegetables or legumes. If you cannot take any of the dietary components for some reason, then a calcium supplement with magnesium should be sufficient. Fermented dairy products are best (yoghurt, kefir, or Calcium Supplement). 2. You need Vitamin D, which is generated in your skin by sunlight. So either get sufficient from sunlight or take a Vitamin D supplement. 3. Reduce consumption of foods containing oxalic acid (rhubarb, plums, spinach, cranberries) and presoak those that contain phytic acid (nuts, seeds, grains, legumes). Oxalates and phytates reduce calcium absorption by binding to the calcium - calcium oxalate is the predominant mineral that forms kidney stones. 4. Cut down your consumption of coffee, alcohol, chocolate, sugar and honey - they inhibit the absorption of calcium. 5. Exercise regularly - exercise helps to prevent loss of calcium and also helps to increase your bone density and mass. By taking each of these 5 tips, you should be able to avoid excessive loss of calcium that can lead to osteoporosis and other problems associated with low calcium absorption. Calcium is also essential for the proper function of your central nervous system and in the maintenance of a healthy blood pressure.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2298) Can Magnesium Relax the Muscles?
Date:
March 04, 2011 04:27 PM
Magnesium The Miracle mineralThe biological role of magnesium is no longer the mystery it once was. Today we are well informed that the presence of minute quantities of magnesium in the human body is necessary for life. Moreover, a well balanced diet incorporating healthy levels of this trace element has been associated with lower susceptibility to fatigue, muscle weakness, and neurological conditions. Deficiency, on the other hand, brings on a long list of symptoms, including muscle spasms, insulin resistance, and even heart failure. It is an important factor of muscle health, and, not surprisingly, an effective muscle relaxant. Facilitates Muscle Recovery In the past few years there was a health concern in connection with the high incidence of magnesium deficiency among the general population, spurring the government to be actively involved in promoting the availability of elemental magnesium in the foods that we eat. Today with many food products fortified with magnesium, it is now becoming common knowledge that this dietary element is indispensable. What the average guy may not know is how important it is to the overall health of the muscles. First off, a significant fraction of magnesium is present in the muscle cells. The energy that you feel during physical exertion, which of course involves the muscles, is generated at the cellular level in the presence of magnesium. However, even when magnesium levels are depleted, each muscle cell still has to endure with the continuing muscular contractions, resulting in a slower rate of recovery. Prevents Muscle Fatigue Do be aware that longer hours at work take a toll on your muscular system. Doing the same things for long periods of time entails the repetitive use of the same muscles, straining these muscles and literally pushing them to the limit. Cumulative trauma disorder, or sometimes called repetitive strain injury, is in fact more common among individuals with low levels of magnesium, the muscles being more susceptible to stress as the body uses up its magnesium reserves. The same is the case with staying up all night or engaging in activities with fewer rewards in that the nervous system plays a role in controlling your muscles. The role of magnesium in combating muscle fatigue transcends its presence in muscle tissues for it is also actively involved in keeping undesirable neurological responses in check. Strengthens Muscle Cells Magnesium is not an herbal remedy for muscle spasms, but a vital constituent of strong, healthy muscles. That being said, there are formulations that must be taken at recommended dosages to produce a relaxing effect on the muscles. This will of course relieve the symptoms associated with muscle problems, including pain, tremors, and stiffness. What must follow is the incorporation of this mineral to your diet or supplementation to ensure that your muscles are protected against their continued exposure to daily wear and tear. Keep in mind that supplying your body with magnesium translates to developing healthier muscles, whether you lead an active life or spend long hours at the workstation.
Have your had your magnesium today?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2247) How does Malic Acid help with Fibromyalgia?
Date:
February 09, 2011 01:18 PM
Malic Acid And Fibromyalgia
If you feel sensitized to pain by otherwise harmless stimuli, then you may be experiencing symptoms of fibromyalgia, which has been recorded to affect up to 4 per cent of the population worldwide. It is characterized by a feeling of weakness in the muscles of the limbs, conscious awareness of abnormal heartbeat, problems concerning bowel movement, and disturbances to sleep patterns. All of these are complaints reported to have been addressed by supplementation of malic acid. The medical community remains inconclusive as to what causes fibromyalgia, some claiming it’s not a disease at all. While symptoms may not be necessarily medical signs, there are innumerable cases that describe complaints we collectively refer to as fibromyalgia. Throughout the past few decades, medical professionals around the world have considered these symptoms as one musculoskeletal disease whereas most neurologists have contended that fibromyalgia is attributable to the abnormalities within the nervous system. Today the American College of Rheumatology has charted nine paired tender points in an effort to describe the symptoms for this condition better. Known Causes in Scrutiny The most common symptoms of fibromyalgia more often than not appear simultaneously with stress-induced medical conditions such as chronic fatigue, anxiety disorders, and depression, but they are known to develop independently. A tissue in the brain responsible for long-term memory and spatial navigation called hippocampus have shown abnormalities among patients of fibromyalgia, thereby affecting sleep patterns, perception of pain, and related cognitive functions. In the latter half of the 20th century it is postulated that serotonin leads to fibromyalgia. Serotonin being a neurotransmitter that governs mood, attention, and pain were found to be significantly decreased in the blood plasma and cerebrospinal fluid among patients who reported to experience this condition. That being said, the introduction of serotonin inhibitors used in treatment of depression has also shown alleviations of pain-related symptoms across the tender point index.
Malic Acid and PrognosisMalic acid was discovered as a constituent of apple juice as early as the 18th century. Reduced levels of malic acid contribute to the maturity of fruits. In human beings it plays a fundamental role as an intermediate in a metabolic pathway that influences the chemical conversion of bioactive compounds like carbohydrates, fats, and proteins into carbon dioxide and water, which in turn convert the molecules contained in the cytoplasmic fluid of cells into energy generated in the mitochondria. The availability of malic acid inside the human body modulates functional activities at the cellular level by speeding up the metabolism of bioactive compounds and consequently the production of energy in use by the cells. That being said, malic acid provides vitality to muscle cells, raising their endurance against stress. In addition, there have been reports that intake of malic acid help elevate levels of serotonin, leading to improved response to pain and better management of fibromyalgia. For now, the tender point index is the primary diagnostic tool for evaluating fibromyalgia, and the use of malic acid has been recorded to reduce pain in these points.
Have you had your Malic Acid today?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2233) The Krebs Cycle - Our Lifes Blood!
Date:
January 13, 2011 05:00 PM
The Krebs Cycle, also known as the Citric Acid Cycle, is an important series of biochemical reactions that are intrinsic to cellular respiration and the generation of energy from oxygen and glucose in aerobic organisms. Although humans can generate energy anaerobically, they cannot do so for long periods and oxygen is essential for life because it fuels the Krebs Cycle. Without this cycle, there would be no available energy to maintain our vital processes.
What is The Krebs CycleWe shall first discuss exactly what the Krebs Cycle is and then its importance in the body. The process takes place within the mitochondria of the body cells. A. The cycle begins with the ten-step pathway of glycolysis, during which glucose is converted to two molecules of pyruvate: no oxygen is required for this step. Basically: Glucose + 2NAD+ + 2P + 2ADP = 2Pyruvate + 2NADH + 2H+ + 2ATP The pyruvate can then undergo aerobic or anaerobic respiration to generate energy. The Krebs Cycle is the aerobic route, and significantly more efficient that the alternative fermentation. B. The two pyruvate molecules are then oxidized to two of Acetyl CoA with the release of carbon dioxide. The two acetyl groups of the Acetyl CoA are donated to Oxaloacetate in the presence of water to form Citrate. C. Citrate then undergoes a number of chemical reactions to arrive back at Oxaloacetate again and the cycle starts all over again by reacting with more Acetyl CoA from Pyruvate and oxygen to form Citrate again. During the cycle more ATP is produced and electrons and other species are sent into the Electron Transfer Chain where most energy is generated. During this cycle three major events occur: 1. During the various transformations of Citrate, specifically when Succinyl-CoA is converted to Succinate, one Guanosine Triphosphate group (GTP) is generated, which then donates a phosphate to Adenosine Diphosphate (ADP) to create the energy molecule Adenosine Triphosphate (ATP). 2. Over the whole cycle, three molecules of Nicotinamide Adenine Dinucleotide (NAD) are reduced to NADH that donates its electrons to the electron transport chain that is responsible for the generation of large quantities of ATP. 3. A molecule of Flavine Adenosine Dinucleotide (FAD) is reduced to FADH2, again donating its electrons to the electron transport system and the generation of energy. Factor 2 and 3 are of more significance to energy generation than factor 1, and are the major means by which the Krebs Cycle generates energy. Electron Transport Chain The Krebs Cycle takes place within the mitochondria, structures that are contained in each of your body cells. Also within these mitochondria are a series of membranes that are very important in the generation of energy. The major energy produced in your body cells comes from the Electron Transport Chain, a series of chemical reactions between an electron donor and an electron acceptor. Such reactions drive the transport of hydrogen ions (H+) across the membranes in the mitochondria. The electron donors are species such as NADH, FADH2 and succinate and the electron acceptors are oxygen molecules. Hence the importance of oxygen in the process of aerobic respiration. The H+ ions are driven across the membranes and result in the conversion of ADP to ATP energy. In essence, the hydrogen atoms and electrons take part in a progressive chain of redox reactions, and at the end react with oxygen molecules and change it to water. The Ultimate Products Ultimately, through the whole chain and cycles of: Glucose to pyruvate (glycolysis) Pyruvate to Acetyl CoA + CO2 (oxidation) Acetyl CoA to Citrate and the entire Krebs Cycle (reduction and oxidation) Krebs Cycle products to the Electron Transfer Chain Electron Transfer Chain to Water and ATP (redox) Final oxidation of hydrogen atoms to water Basically: Glucose + Oxygen + 30ADP = Carbon Dioxide + Water + 30ATP This is not balanced of course, and the ATP could be anything from 29 to 38, though 29.85 is the most accurate calculation to date. The entire process of glycolysis, oxidation, Krebs Cycle and Electron Transport Chain is powered by a series of enzymes and a small amount of ATP energy. Glucose and oxygen are used up as the raw materials and ATP energy molecules are the product. It has been calculated that the total ATP yield obtained from one molecule of glucose lies between 29.5 and 30 molecules of ATP. The Importance of the Krebs Cycle to Your Body Were it not for the Krebs Cycle you would not be able to generate energy efficiently from your food. In particular, the carbohydrate content of your food. Carbohydrates are available in your diet from two sources: simple and complex carbohydrate foodstuffs such as cereals and grains, and fats and oils from animal and vegetable sources. They are also available from proteins, which are composed of amino acids at the head of the molecule with a carbohydrate tail. Carbohydrates by definition contain only carbon, hydrogen and oxygen molecules, and can be converted to glucose within your body. Proteins can be deaminated and then the carbohydrate portion again converted to glucose. In fact, your body will initially use the carbohydrates in your diet as a source of glucose for its glycolysis to pyruvate, then the fatty tissue in your body, then the proteins will be deaminated so your body can get to the carbohydrate they contain. Were it not for the Krebs Cycle, your body could not use the glucose as described above to generate energy. The only option open to it would be anaerobic respiration, or energy production in the absence of oxygen. ATP is still generated, but much less efficiently. Anaerobic Respiration Anaerobic respiration is basically respiration without oxygen. If there was no Krebs Cycle, then this is the only way your body would have to create energy. Because no oxygen is actually needed for glycolysis or the Krebs Cycle, anaerobic respiration can proceed right to the end of the Electron Transport Chain. Then instead of oxygen being used as the terminal electron donor, it has to be another species such as nitrate or sulfate. Because the Reduction Potential of these species is much lower than that of oxygen, the amount of ATP energy produced is also much lower. Your body tries to compensate by producing even more pyruvate and the excess is removed through lactic acid fermentation. Although this also generates ATP energy enough for short-term use, it leads ultimately to lactic acidosis and a reduction in pH, causing pain and vomiting. Ultimately, if oxygen is not forthcoming, the brain runs short of the energy needed for it to work and you die. There is insufficient ATP generated from anaerobic respiration to maintain human life. Conclusion The Krebs Cycle is of critical importance for the production of energy: not just the energy to enable you to run fast, but to enable your metabolic processes to continue. It is needed for both aerobic and anaerobic respiration, and while lactic acid fermentation can be used by your muscle cells as a brief but effective means of generating short-term energy, it is insufficient to maintain the needs of your metabolism. Without the Krebs Cycle, mammalian and most other animal life would not be viable and the world would be populated by anaerobic bacteria.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2217) Protect your body from Damaging UV radiation With PABA
Date:
September 02, 2010 12:34 PM
PABA - The oral Sun Screen ProtectionPara-aminobenzoic acid, otherwise known commonly as PABA, is an antioxidant, meaning that it possesses chemically reducing properties that can destroy the free radicals that disrupt skin cell membranes and so lead to wrinkling. At one time it was used in sunscreens where it was believed to protect against UVB radiation though not UVA radiation. However, after it was discovered that UVA radiation can damage the skin more than UVB, its use has reduced considerably although it can still protect your skin by virtue of its antioxidant properties. Free radicals are small oxygenated molecules that rupture the membranes of your body cells and also oxidize LDL cholesterol, causing it to form plaques on the internal walls of your arteries. That eventually blocks them and can cause heart attacks and strokes. PABA can destroy these free radicals and ultimately prevent this from happening. In doing so, of course, it also destroys the free radicals generated by the UV radiation in sunlight and so helps your skin to keep looking fresh even when exposed to strong sunlight. PABA will not offer complete protection against excessive sunbathing but will help, and it is free radicals that give those that live in hot countries that wrinkled and leathery look to their skin. PABA can protect you from that.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2182) Glutathion, Antioxidants, And The Body
Date:
July 14, 2010 02:41 PM
Glutathione is an important water-phase antioxidant that is an essential component in the glutathione peroxidase system. Glutathione peroxidase enzymes are crucial for detoxifying peroxides including hydrogen peroxide, which is generated within cellular membranes and lipid-dense areas of the cell, especially the mitochondrial membrane. Severe glutathione depletion often leads to cell death, while experimental glutathione depletion has been found to induce cellular apoptosis. A cellular level of glutathione depletion seems to cause extensive damage to the mitochondria. Depletion of mitochondrial glutathione may, in fact, be the ultimate factor that determines a cell’s vulnerability to oxidative(free radical) attack. The mitochondria is the most crucial place for glutathione presence, as the cascade of oxidation-reduction reactions complete the final steps in respiration take place here. Throughout this process, which is called oxidative phophorylation, electrons invariably escape and react with the ambient oxygen in order to generate toxic free radicals. It has been estimated that 2% to 5% of the electrons that enter the mitochondria are converted into reactive oxygen species that generate considerable oxidative stress for the cell. These free radicals cause an immediate threat to other cellular components, such as the DNA, enzymes, structural proteins, and lipids. The cumulative damage that is caused by oxygen and other free radical species is now determined to be the principal contributor to the degenerative disease process and the progressive loss of organ function that is commonly recognized as aging. Because of this, the cell is constantly challenged to destroy these free radicals before they can inflict any lasting damage. Minimizing oxidative attacks may actually be the ultimate challenge of being alive. Because of this, the reducing power of glutathione is of huge important to the cell. Glutathione is important for helping to regenerate other antioxidants that are depleted from their constant work to fight off free radical challenges. Regeneration that is glutathione-induced may be the mechanism that is actually used by the cell in order to conserve lipid-phase antioxidants, vitamin A, vitamin E, and the carotenoids. It has been confirmed by recent investigations that dietary vitamin C can actually protect us against tissue damage that results from glutathione depletion. Additionally, supplementation with glutathione or its precursors can also quickly replenish any vitamin C deficiencies. Because of this, glutathione and ascorbic acid, both of which are pre-eminent cellular antioxidants, are tightly linked, as glutathione can conserve vitamin C and vitamin C can conserve glutathione. When they are both present, these two antioxidants protect the entire spectrum of biomolecules that are found within the cell, as well as facilitate the cell’s best performance. It has been said that the glutathione status of a cell may be the most accurate single indicator of the health of the cell. This means that as glutathione levels go, the health of the cell will go as well. Glutathione is available in capsule or tablet form at your local or internet health food store. Always choose name brands to ensure quality and purity of the glutathione supplement you choose to purchase for consumption.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2171) Antioxidants and your health
Date:
May 17, 2010 10:44 AM
There is an impressive amount of scientific evidence supporting the health benefits of supplementing with a wide variety of antioxidants. Consequently, there are many health practitioners who have begun to recommend high dietary intakes of these crucial nutrients in order to prevent against oxidative stress. It was anticipated over two decades ago by leading researchers that high-dose supplementation with antioxidants is developing a significant role in the prevention and treatment of a lot of today’s common illnesses. It should be noted that antioxidants do not work in isolation. When an antioxidant neutralizes a free radical, it, itself, is oxidized and must be regenerated by another antioxidant before it can be used again. Because of this, it is crucial to supplement with a wide variety of antioxidants, in order to reflect what actually occurs in nature. Vitamin C, an aqueous-phase antioxidant, is the main guard against oxidative attack in the extra-cellular matrix, as well as within the cytoplasm of the cell. Vitamin C happens to be a substrate for eight different enzyme systems that are involved in various cellular functions. Among these functions are collagen synthesis, ATP synthesis in the mitochondria, and hormone biosynthesis. Its main antioxidant partners are vitamin E and beta carotene, both of which help to regenerate vitamin C. Of all the antioxidants, it seems as if vitamin E offers the greatest protection against heart disease because of its ability to protect the cardiovascular system from oxidative damage. It is lipid-soluble, making it an important component of the cell membrane, where it works to protect the cell against lipid peroxidation and control oxidation-induced inflammatory events. Recently, the gamma tocopherol form of vitamin E has shown a great deal of promise in its ability to reduce the risk of several oxidative stress related disease. Beta-carotene is a member of a diverse group of photosynthetic pigments. It plays a huge role in human nutrition. As an antioxidant, it possesses a double-bond structure that allows it to react effectively with single oxygen radicals, absorbing and diffusing their energy. Beta-carotene also acts as a precursor for vitamin A by supplying a portion of the body’s requirement for the vitamin. This act alone plays a central role in the chemistry of vision. Beta-carotene and vitamin A both prevent the oxidation of cholesterol, reduce oxidative damage to DNA, and disable oxygen free radicals that are produced by exposure to sunlight and air pollution. These antioxidants are also involved in the activation of gene expression and the control of cell differentiation. When combined together, vitamin C, vitamin E, and beta-carotene produce and important antioxidant trio that plays a huge role in fighting oxidative and inflammatory events. There are several other antioxidants that should be noted due to their ability to work synergistically with the vitamin C, vitamin E, and beta-carotene trio. These include vitamin A, alpha-lipoic acid, lycopene, coenzyme Q10, and the antioxidant mineral, selenium. In order to determine whether a nutrient provides antioxidant support, scientists question whether the product contains vitamin C, vitamin E, vitamin A, beta-carotene, alpha-lipoic acid, lycopene, coenzyme Q10, and selenium and to what strength these vitamins and minerals are per serving.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2160) Fight Cold Sores And Build Collagen
Date:
April 29, 2009 10:18 AM
Lysine is an essential alpha-amino acid, in that it cannot be biosynthesized by the human body, and therefore must be taken in your diet or as a supplement. It is synthesized in plants from aspartic acid, and metabolized in the body to produce acetyl-Coenzyme A (acetyl-CoA). Before discussing its action on herpes, we shall first have look at how Lysine helps with the formation of collagen. Collagen is a protein that is produced in the body from lysine and proline, another amino acid. In fact the primary role of amino acids in your diet is as building blocks to form the much larger protein molecules. Collagen is fibrous, and forms the connective tissue such as cartilage, ligaments, tendons, blood vessels and skin. Even the external parts of the ears. It literally holds our skeletons together, and wraps the whole body up in skin, so if we had no collagen we would literally fall apart! Collagen is also used by body cells to form the matrix that the body cells use to attach to each other and is one of the most important types of tissue in your body. It is so ubiquitous that over 30% of the protein contained in your body is collagen, and it is designed for its structural strength as opposed to its ability to take part in chemical reactions as other proteins are. Lysine and Vitamin C are essential for the maintenance and formation of collagen. There is not a lot of lysine in collagen - only about 4%, but it is very active in the cross-linking that forms the fibrils of collagen. Fibrils are the hair-like structures formed in a triple helix arrangement by three protein chains twisting round one another. The fibrils are bundled together in a straight line that has amazing tensile strength. The tensile strength of collagen is, weight for weight, stronger than steel! In order for lysine to take part in this process effectively, some molecules have to be hydroxylated and others oxidized, forming aldehydes. Things can go wrong here, and deficiencies in the metabolic process can lead to some heritable conditions, or diseases of connective tissue. Among these are lathyrism, Cutis-Laxa and the Menkes kinky hair syndrome. However, lysine is a very versatile amino acid, and not only is it necessary for the biosynthesis of all proteins, but is also heavily involved in the production of enzymes, hormones and antibodies. It is an important component of the calcium absorption process, and also, as previously stated, can be used in the treatment of herpes simplex. This form of herpes is known commonly as 'cold sores', and is a result of the activity of the herpes virus. Viruses do not reproduce in order to ensure the 'continuation of the species', but replicate. In order to achieve this it requires the help of another amino acid, arginine. This is a common amino acid whose sources include grains, seeds, peanuts, raisins and chocolate. Lysine and arginine competes for the absorption and entry of tissue cells, and reduces the strength of arginine, so preventing the growth of herpes. For this reason a supplement of lysine can be used to reduce the effects of the herpes simplex virus, and lessen the symptoms of the cold sore. However, it is not only cold sores but other forms of herpes that lysine can help to relieve. Herpes zoster is a virus that causes shingles. This virus is generated by the reactivation of the dormant varicella-zoster virus left in the tissues after chickenpox. It is a recurrent condition, and lycine can help to reduce recurrences as well as its severity. Apart from being an effective defense against herpes, and forming collagen, the amino acid imparts several other benefits to the human body. Among these is osteoporosis. L-lysine is involved in calcium absorption in the intestine, and also helps to reduce the loss of calcium in the urine. In osteoporosis we have to try to make every calcium molecule ingested in the diet to be incorporated in the bone structure. L-arginine can work with lysine to enhance the activity of the body cells that produce bone. Canker sores are often mistaken for cold sores, but they are actually quite different. They are small sores inside the mouth, and appear in the form of very painful ulcers. The cause is unknown, but is believed to be a virus, and lysine appears to help the condition. Although there have been no proper clinical tests carried out on its use as a remedy for canker sores, lysine appears to help, and a supplement is recommended as a treatment by many doctors. It will do no harm, and anybody suffering from these tiny but painful sores will try anything. Although lysine deficiency is rare, it can occur, particularly amongst those observing a vegetarian macrobiotic diet, and also in athletes who frequently undertake vigorous exercise, especially with too little recovery time. The effects of a deficiency are fatigue, nausea, appetite loss, anemia, slow growth and kidney stones. The latter is likely due to a failure to absorb calcium, that L-lysine promotes, and the formation of calcium oxalate and other insoluble salts in the kidney. Dietary sources include beans and other legumes, and although it should be available in cereals, baked foods and doughnuts, for example, the carmelization of sugars binds the lysine to the sugar, and so reducing its bioavailability. However, you can also get it in cheese, eggs, tofu and red meats. If you are taking an arginine supplement, you should consult your physician prior to taking lysine. The reason for this is that lysine and arginine share biochemical pathways, and arginine can reduce the effective concentration of lysine. However, it has not been tested by the FDA, nor approved, and any use is at your own risk. This risk appears to be very small, although its manufacture is not regulated. However, do not let this bother you: the proof of the pudding is in the eating as they say. Many have found lysine to be effective with collagen or herpes problems, and a supplement of between 3,000 and 9,000 mg per day is recommended for those with herpes viral infections. It is not recommended for children under two years old. Lysine is available at your local or internet health food store at discount prices. Look for name brands to ensure purity and quality of the product you purchase. Another Great Cold Sore Remedy is Red Marine Algae!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1998) Strengthen The Liver and Kidneys With Leucine
Date:
April 27, 2009 02:08 PM
L-leucine is an amino acid that is used by the body to fuel exercise and muscle-building to provide you with that athletic edge that gets you ahead of your opponents. It does so in a number of ways, none of them specifically by the direct generation of energy as such. It is also an essential amino acid, since it cannot be manufactured by your body and hence must be taken as a supplement or as part of your diet. Foods rich in leucine include nuts, whole wheat products such as wholemeal bread, and brown rice. It is a hydrophobic amino acid, meaning that it does not like water. It is also one of three essential branched chain amino acids, the other two being L-valine and L-isoleucine, and offers many benefits to athletic performance that shall be discussed below It also helps to preserve the body's stores of glycogen, used as an emergency energy source. Other than these properties, it possesses others, such as the maintenance of the nitrogen balance in the body. So how does it work to fuel your body while you are exercising? The answer is not as you might think. L-leucine doesn't increase your energy levels as creatine does when it elevates your ATP (adenosine triphosphate) levels. ATP is the molecule of energy that is synthesized in your body cells, and is then converted back to ADP, the diphosphate, with the release of energy in the form of muscular contractions. This amino acid is what is referred to as a 'limiting' substance, in that the other amino acids cannot do their jobs in your body unless you have sufficient L-leucine in proportion to them. Specifically, you need two parts of L-valine and two parts of L-leucine to one part of L-isoleucine for optimum usage of the food that you eat. Therefore you cannot just take the supplement without considering how much should be taken to ensure this balance. Excess will be wasted and a deficiency would fail to make proper use of the protein content of your food. If you suffer from a deficiency, therefore, your body cannot make best use of the protein in your diet to the extent that muscle tissue will not be generated during exercise. In fact it causes catabolism, or the breakdown of muscle tissue, resulting in a loss of performance and possible increase in fatty tissue as opposed to lean muscle. The only way to build muscle is take in sufficient nitrogen in the form of amino acids and protein, along with L-leucine to put that protein to best use. One of the major properties of L-leucine is in stimulating the synthesis of skeletal muscle tissue and by using a supplement, the protein balance can be positive after a workout. It has been shown that this protein balance is generally negative until specifically L-leucine is consumed. The way it works is to activate a muscle-generating pathway known as mTOR (mammalian Target of Rapamycin). mTOR is normally activated when the levels of ATP in the muscle cells is high, and when these levels drop then mTOR is deactivated. The activity of mTOR is sensitive to the concentration of L-leucine, and when the concentration of the amino acid in the body rises it informs mTOR that the protein in the diet is sufficient to manufacture skeletal muscle tissue, and so mTOR s activated. Exactly how this is done is unknown, but is a fact the mTOR depends upon both L-leucine concentration and also ATP levels. This amino acid also decreases catabolism through a number of different mechanisms, one of which involves increasing insulin levels. In fact, when insulin and L-leucine levels increase at the same time, there is a synergy that promotes the synthesis of new protein. Not only that, but the response of insulin to the presence of carbohydrates is enhanced, this resulting in an enhancement of your body's metabolism. The amino acid can also be used to help those suffering from kidney and liver problems because it increases liver protein synthesis. It is therefore a useful adjunct both to diabetics and those suffering from liver and kidney disease. However, because L-leucine is an essential amino acid with so many important properties, a deficiency can have specific consequences. Catabolism has been stated earlier as one such reaction to a deficiency, and others include decreased energy levels and irregularities in the levels of blood sugar. Everything about this substance is not good however, and when taken by itself in excess, it can reduce the amount of the other amino acids in the blood, particularly of the other two branched chain amino acids (BCAAs). This in turn upsets the balance of amino acids, and reduces further the ability of the body to produce muscle tissue until a balanced supplement is taken. Leucine also helps to maintain the nitrogen balance. It is essential for the human body to maintain a positive nitrogen balance, and L-leucine supports this. In fact, one study has demonstrated that after 12 hours infusion with L-leucine, nitrogen balance was improved by as much as 23%. A supplement alone is not always sufficient to maintain a positive nitrogen balance. It is generally essential that you rest your body for a sufficient length of time to allow protein to be generated. If you don't take the required amount of rest, a surplus of protein could be used to maintain energy levels rather than replace lost protein and maintain a good nitrogen balance. A positive nitrogen balance is essential for the generation of muscle tissue, such as in bodybuilding for example, since all proteins contain nitrogen and the net nitrogen intake must exceed the excretion rate. Not in gaseous form, of course, but in the intake of amino acids and proteins. The more positive your nitrogen balance is, the faster you will recover after exercise. It is essential for anabolic exercise. L-leucine, therefore, is a supplement that can help to maintain your current muscle mass while undergoing strenuous exercise, in addition to increasing it while resting. It offers other health benefits, one being helping to maintain clarity of thought in the aged. However, it is for its effect on muscular build-up and the athletic edge that provides that the supplement is most commonly taken.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1997) L-Alanine Non Essential Amino Acid
Date:
January 05, 2009 04:31 PM
L-Alanine is one of 20 amino acids that are used by the body to manufacture the proteins essential for life. Each protein possesses specific biological properties that are imparted by the sequence of amino acids it contains. Proteins control the chemistry that takes place within the cells of our body, and comprise all of the enzymes that catalyze the body's biochemistry. Amino acids are also the building blocks of DNA that determines the genetic make-up of individuals, and that also provides recipes or templates for the production of proteins from amino acid sequences. There is a different DNA template for every protein required by the body that determines which of the 20 amino acids are needed, and in what order they are to be combined with one another to manufacture the desired protein. 10 of these 20 amino acids can be synthesized by your body's biochemistry, the other 10 being essential parts of your diet. If you fail to include just of these 10, then your body will break down its proteins until it has obtained a sufficient supply of that amino acids for its needs. That involves muscle and other tissue degradation, and is one of the symptoms of malnutrition. Amino acids are not stored, and a daily supply is essential to avoid these symptoms. L-Alanine is one of the ten that the body can manufacture, and used by the body to help build protein and also to enable the body to make use of glucose to generate energy. It does so as part of what is known as the glucose-alanine cycle. During anaerobic exercise, such as in weightlifting and sustained running, muscles produce lactate and also alanine. The alanine is passed on to the liver where it is converted to energy via its conversion to glucose. This is not a particularly efficient means of creating energy because a byproduct of the process is urea, the removal of which in turn requires energy. However, it serves its purpose as an energy source once the liver is depleted of glycogen. In fact that is the major use to which alanine appears to be put by the body: the conversion of glucose to energy. The way the glucose-alanine cycle works is that a process known as transamination produces glutamate from the amino groups of amino acids that are degraded during exercise. Glutamate is then converted to pyruvate by means of the enzyme alanine aminotransferase, with the production of alanine and alpha-ketoglutarate. This is a reversible reaction, and after the alanine has been carried by the bloodstream to the liver, the reaction reverses with the regeneration of pyruvate that undergoes gluconeogenesis (generation of glucose). The result of this is glucose that returns to the muscle tissue to provide more energy. The glutamate is broken down to the ammonium ion in the mitochondria, which in turn enters the urea cycle with the production of urea. In a nutshell, then, the glucose-alanine cycle removes glutamate and pyruvate from muscle tissue to the liver where glucose is generated from the pyruvate and returned to the muscle. Since gluconeogenesis involves the expenditure of energy, and this occurs in the liver rather than in the muscle, all the energy in the muscle can be used for muscle contraction. L-Alanine possesses other properties, among them the ability to help maintain the health of the prostate. A study of benign prostatic hyperplasia (enlarged prostate) indicated that treatment with L-alanine, glutamic acid and glycine over a period of three months reduced the symptoms. However, make sure that you consult your physician before using alanine in this way. This is not because there are any known adverse side effects, because there are not, but because it I always wise to so with any supplement taken with a view to treating any medical condition. A less obvious application derives from the fact that it forms a stable free radical when deaminated. Deamination can be initiated by radiation, and so the concentration of this free radical can be measured to ensure that the correct dose of radiation is being given in dosimetric radiotherapy. It is not always easy to control the dose accurately, and this property of alanine allows it to monitored and to ensure that it is neither too low to have the desired effect, nor dangerously high. Although it is a non-essential amino acid, and can be produced by the body, a dietary supply or supplement is advantageous if extra energy is required. Good dietary sources of L-alanine include meats, seafood, eggs, nuts, beans, seeds, brewer's yeast, corn and legumes among others. Supplements are also available, and useful for body-builders, weightlifters and others involved in anaerobic exercise. Due to the glucose-alanine cycle, it can possibly provide energy when lactate build-up would otherwise lead to muscle cramps. Those for whom a supplement could be useful are athletes and others who are trying to build muscle and stamina, or reduce their body fat and also the obese and overweight for the same reason. There is also evidence that a combination of the amino acids alanine, glycine and arginine can help to reduce arterial plaque from oxidized low density lipoproteins, and can also help to reduce high blood pressure. Deficiencies are rare, although groups that do not eat meat should be careful to eat foods with a good alanine content. There are no known side effects of a deficiency since the body will generate what is needed for normal purposes, and while the supplement appears to have no side effects, it is advisable that pregnant and lactating women should first seek medical advice. The same applies if you suffer from hypertension or diabetes. High doses of alanine might also affect those with kidney or liver disease.
Although the benefits of supplementation of L-alanine might not be immediately obvious, the results and the science indicate that it is effective in making better use of blood glucose in that the adenosine triphosphate (ATP) created in the muscle tissue is allowed to be expended on muscle contraction while the glucose-alanine cycle provides the energy needed for gluconeogenesis.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1958) Flaxseed Oil
Date:
December 23, 2008 11:44 AM
Although it is important to stress that the fatty acids found in flax are essential, flax also contains substances called lignans. Lignans are special compounds that demonstrate impressive health benefits, as they seem to be responsible for assisting the immune system in many ways, along with helping to prevent some types of cancers. Because flax contains lignans, it is an even more beneficial to the body when consumed in this form. Flax is one of the most abundant sources of lignans, a type of phytoestrogen that interferes with estrogen metabolism in animals and humans. This property gives lignans the ability to help in the prevention of both fat and hormone-sensitive types of cancer. Lignans also benefit the body by providing antibacterial, antifungal, and antiviral activity that helps the immune system to function optimally. All of the benefits of flax are still yet to be known, but it has been established that flax is also a good source of fiber. There have been several studies which confirm that flaxseed can be a cholesterol-lowering agent similar to oat bran, fruit pectin, and other food ingredients that contain fiber. Because flax packages both omega-3 fatty acids and soluble fiber together, it presents two ingredients which provide healthy blood lipid patterns. Flaxseed contains beneficial amounts of both soluble and insoluble fiber, giving it potential cancer-fighting ability especially in colon cancer. When selecting a healthy diet, it is important to consider your sources of essential fatty acids. Essential fatty acids are fragile and easily damaged by air, high temperatures, and food processing, so you are unlikely to get all of the EFAs that you need, even if you are careful to use vegetable oils for cooking. Most of the oil that we consume today has been heavily processed, which damages essential fatty acids. When choosing flax oil, you’ll want to take into account the same considerations, looking for oil that has not been damaged by processing and is packaged to block all light from contact with the oil. Not all flax oils are the same, with there being a great deal of variation in quality and purity as a result in differences of how the oil is expressed. Most flaxseed oils are mechanically pressed out through an expeller, in which great amounts of heat and pressure can be generated. The higher the temperature, the better the yield of oil, but the lower the quality of oil. Many manufactures willingly sacrifice quality for quantity. The best way to measure the quality of oil is by taste, with the degree of bitterness being a close approximation of the level of lipid peroxides. The best source of high quality flaxseed oil can be found in health food stores where inventory turnover is highest. Some good guidelines to go by in selecting a good flaxseed oil include: making sure the flaxseed oil is derived from 100% certified organic flaxseed; making sure the oil is as fresh as possible and not past the expiration date; making sure that the oil is expeller-pressed or cold pressed; using flaxseed oil that is high in lignans to gain the most benefit.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1953) Guggul
Date:
November 10, 2008 10:30 AM
Guggul is a natural herb supplement that may help lower cholesterol, yet few in the Western hemisphere know much about it. Guggul is otherwise known as the Mukul myrrh tree, and is a plant of the Burseracae family with small red or pink flowers. It is found across central Asia over to North Africa, although is very common in the northern areas of India where the climate is more semi-arid than equatorial. Guggul does not like a lot of water and can thrive in ground where the soil has few nutrients. Its Latin name is Commiphora wightii, and it grows about 12 feet high. It has been predominantly used in the Ayurvedic medicine of ancient India, and like many such ancient remedies and treatments, is now used in modern medicine to treat specific conditions: conditions such as some forms of heart condition, where it has been found to be able to lower your blood cholesterol levels, weight loss and some forms of arthritis and other inflammatory conditions. However, it has been used so successfully over the years, particularly in India, which it is now in danger of extinction and is contained in the Red Data List of the World Conservation Union that lists endangered species. So what is so special about this plant that makes it so popular? To get the answer to that we have to go back a bit in its history, although not quite as far as the two or three thousand years that it is known to have been used in traditional Hindu medicine. The active ingredient is found in the sap of the tree, and is used to fight against obesity and other diseases that can be caused by excess weight or cholesterol, such as arthritis, obesity and atherosclerosis. Until recently it has had very little support for its claims from conventional medicine. It was in the 1960s that an ancient Sanskrit text was found that recommended guggul as a treatment for high cholesterol levels. Since that discovery, research has focused on the plant's anti-cholesterol properties, and a great deal of evidence has been gathered supporting the claims of that ancient text. So much so that the Indian government has approved the use of guggul for the treatment of high cholesterol levels, largely because it has been found very effective in reducing the levels of 'bad' LDL cholesterol in the blood while increasing the levels of the beneficial HDL cholesterol. Several trials have supported this, including one study involving 228 patients that showed the extract to be equally as effective as the anti-cholesterol drug clofibrate. That is not all, and other studies included one in which a decrease in LDL cholesterol of almost 13% was measured in a double blind study involving 61 subjects, of which around half received a placebo. An average 12.7% reduction in LDL cholesterol, 12% in triglycerides and 11.7% in total cholesterol was experienced by the group given the guggul extract. Every 1% drop in total cholesterol is associated with a 2% decrease in the risk of heart disease. Guggul reduces the levels of harmful cholesterol in your blood by converting it into bile. The plant extract contains substances given the name guggulsterones that block the activity of a protein that regulates the metabolism of cholesterol in your body known as FXR (the Farsenoid X Receptor). This protein can increase the risk of you contracting heart disease by preventing the liver from converting cholesterol into bile acids, so that the concentration of cholesterol in your blood continues to build up. The problem with bile acids is that once they reach a certain concentration in your body, the FXR comes into play and stops more being produced. Guggulsterones prevent the FXR from doing this, and so helps the liver to destroy more cholesterol. There is a reason for the body not allowing too much bile acid to be generated, but for those with excess cholesterol, it is more beneficial for this regulation to be prevented, and more cholesterol to be destroyed by the liver. It is the resin of the plant that is prized, being extracted from the bark in much the same way as rubber is tapped. It is also used in fragrances and perfumes in addition to its medicinal uses, and the dosage generally recommended is 1500 mg (1.5 grams) twice daily. However, it is not recommended for those suffering liver disease, irritable bowel syndrome, Crohn's disease or any form of diarrhea, and should not be taken by those on beta blockers. It is not only for its cholesterol-lowering properties that guggul is prized, however. Another property it possesses is its ability to render blood platelets less sticky, and so reduce the risk of coronary disease, and prevent the formation of blood clots and thrombosis. Another use it has found is in the field of weight loss, where it has been found effective in reducing the weight of obese adults. It does so by the activation of lipolytic enzymes and increased levels of triiodothyronine (T3), believed to be due to the formation of T3 from T4 (thyroxine) in the liver. T3 increases the metabolic rate, and the rate of the breakdown of glycogen and gluconeogenesis: the biosynthesis of glucose. It also causes cholesterol to be broken down and increases the rate of lipolysis - the breakdown of fats stored in fat cells in the body. Studies have shown that those taking guggul lost up to 6 times the weight of a control group within 15 days, and the practice is going along with the theory. Not only that, but when you are on a diet, your body is likely to respond by decreasing levels of triiodothyronine, and so reducing the rate at which fat burns. Hence, your diet does not help you top reduce weight as quickly as it could. Guggul, however, stimulates the production of T3, and so you are not only taking less fat into your body, but are also burning it up at an accelerated rate. Other uses to which the resin has been put are based upon its anti-inflammatory properties. It has been found to be an effective treatment for some forms of arthritis and also in the treatment of acne. The active inflammatory ingredient is believed to be myrrhanol A, a polypodane-type triterpene, which would also explain the antioxidant effect of guggulipid on lipid peroxidation.
Guggul is a versatile plant, and a good supplement to take for anybody suffering increased lipid or cholesterol levels, and who wants to increase the weigh-loss effect of their diet. However, make sure that you purchase a supplement standardized on its guggulipid content.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1933) Green Tea Extract
Date:
October 23, 2008 01:43 PM
Green tea is a form of tea made from the leaves of the Carmellia Sinensis, a shrub that is native to China and has spread to other areas of Asia including Japan and the Middle East. Drinking it is believed to impart many health benefits, including the prevention of obesity, heart disease and some forms of cancer and it has been used in traditional Chinese medicine for over 400 years. Tea is known to have been consumed in China for around 5,000 years, and used, not only in Chinese medicine, but also in that of Japan, Thailand and India for a number of ailments including regulating blood sugar, treating wounds and digestive problems. The drinking of green tea to benefit the heart and other vital organs is described in the Kissa Yojoki (Book of Tea), written in 1191 by Eisai, a Japanese Zen priest. This two-part book talks about the various medicinal benefits of green tea, such as preventing fatigue, curing beriberi, quenching thirst, clearing the thoughts, maintaining health of the urinary tract and improving digestive problems. It also explains how to grow tea and how to prepare and use the leaves. The methods of treatment of various ailments and medical conditions are described in the second part of the book. The active ingredients in green tea are catechins, polyphenols with strong anti-oxidant properties. Antioxidants are important components of your diet due to their effect on free radicals. These are small molecules, generally oxygenated, such the superoxide cation and hydrogen peroxide that are generated during normal metabolic processes and also ingested in pollutants such as traffic and factory fumes and insecticides. Free radicals are also formed by the effect of the ultra-violet component of sunlight on your skin and other tissues. The effect of free radicals on your body can be devastating, and they not only destroy cell membranes but also oxidize such molecules as the low density lipids (LDL) that carry cholesterol around your bloodstream. This allows the LDLs to be absorbed by the white blood cells and then deposited as fatty plaques in the walls of your arteries. The end result is a thickening and hardening of the arteries that leads to a condition known as atherosclerosis, where the blood supply to the brain and heart muscle is restricted, which can in turn lead to strokes and heart disease. Their effect on your cells is to cause cancer and premature aging, among others, and free radicals are also believed to play a part in conditions such as Alzheimer’s and Parkinson’s disease and also inflammatory diseases such as arthritis and diabetes. They can also cause damage to your DNA. It is essential, therefore, that these free radicals are destroyed as quickly as they are generated, and that is what antioxidants do. You might be more familiar with the antioxidants Vitamins A, C and E, and phytochemicals such as flavonoids and carotenoids, but there are many substances available to you that are even more powerful such as the polyphenols found in green tea. Epigallocatechin gallate (EGCG) is the most powerful of these with antioxidant properties at least twenty five times that of Vitamin E, and 100 times that of Vitamin C. EGCG comprises around 10-50% of the total catechin content of the tea and studies indicate that it likely helps to protect against DNA damage by free radicals, to protect against oxidation of LDL, provide protection against the damage of ultra-violet radiation and to protect you from the free radicals that are generated by smoking tobacco and general airborne pollution. There are suggestions that the bioavailability of EGCG can be increased by consuming black pepper when drinking green tea, possibly due to the presence of piperine in the pepper. The piperine appears to retard the intestinal glucuronidation of EGCG and so allow more of it to be absorbed as opposed to excreted. So if you are using green tea for health reasons, spice up your food with a small amount of black pepper - that's all it needs. You don't have to smother your food in it! It should be stressed that these tests were carried out on animals, although the biochemistry involved is much the same. The oxidation of fat by your metabolism to provide energy is a very important factor in weight control. If the contribution of the fats you ingest to the energy generated by your metabolism is low, then the fats can go on to be deposited in your body. This is not only unsightly, in that it can basically make you look 'fat', but is also dangerous to your health. Fat deposits around your midriff and round the major organs of your body can be extremely damaging and a severe risk to your health. It has been shown by a recent study in the UK (Birmingham University) that those taking green tree extract displayed a 17% increase in fat oxidation over those given a placebo. Not only that, but the ratio of fat oxidation to the overall energy expenditure showed a similar differential between the study and the control group. This provides evidence of green tea extract being able to control your weight by burning fat, and also to improve the tolerance to glucose and sensitivity to insulin of healthy people. Many other health claims have been made for green tea extract, although many of these have little, if any, scientific basis. Among these are the claims that it can treat multiple sclerosis and be used to treat cancer, although claims that it can prevent the destruction of cell membranes due to its oxidative effect are supported by the biochemistry, if not the medical proof. There are cases where theoretical biochemistry can explain many of the applications of ancient remedies without needing modern day studies to support it. Some of the research supporting the green tea theories include: 1. In 2006, a study was announced that had followed over 40,500 Japanese men and women, aged between 40 and 79, that had no history of coronary heart disease, stroke or cancer starting in 1994. It was found that those who drank at least 5 cups of tea per day had a 16% lower risk of dying from any cause and a 26% less risk of dying from cardiovascular disease than those that drank less than one cup of tea each day. Since cardiovascular disease and cancer are the major causes of death world-wide, these are significant results. 2. Again in 2006, it was reported in the American Journal of Clinical Nutrition that studies indicated that a higher consumption of green tea was associated with a reduction in human mental impairment when compared to the average. 3. Yale University School of Medicine reported later that year that, in spite of smoking more than their western counterparts, Asians suffered lower rates of cancer and heart disease, and put that down to them drinking over 4 pints of green tea daily. It was the polyphenol content of green tea and its antioxidant effect that was proposed for this result, known commonly as the 'Asian paradox'. A specific reason given for this was the antioxidant effect preventing the oxidation of LDL cholesterol, and its subsequent deposition in the artery walls. 4. Another component of green tea is the amino acid L-Theanine that promotes relaxation, and it is believed that this could help to fight stress by inhibiting the excitation of cortical neurons.
There is a lot more evidence for the health benefits of green tea, and once again it appears that the ancients have been proved correct. Perhaps we should pay more attention to ancient remedies, although without the proper evidence much of it is ignored - for the time being at least. Green tea, however, has generally been accepted due to the research and studies carried out on ECGC (Epigallocatechin gallate) and in additional to the traditional form, is also available as a dietary supplement.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1923) Green Coffee Bean Extract
Date:
October 22, 2008 04:59 PM
It is known that aging is largely a result of the effect of free radicals on our body cells, and that green coffee bean extract can be used to fight against these. While we intuitively understand what the term ‘aging’ means, very few people can actually describe it in words, although there are several theories of why it occurs. The most viable of these include the Error Catastrophe Theory, related to faulty molecular transcription and errors in cellular function, the Crosslinkage Theory, in which progressively increasing cross-linking between proteins slows the body functions down, and the Neuroendocrine Theory, in which changes in homeostasis and hormone levels occur through time due to an increasing loss of sensitivity of receptors to feedback inhibition. However, by far the most acceptable and best understood theory is the Free Radical Theory of Aging, which green coffee beans have been found to help fight, and it is on that which we shall focus here. The Free Radical Theory of Aging Free radicals are oxidants created by unpaired electrons. Electrons generally go around in pairs, but occasionally molecules lose one of these electrons, creating a situation where it possesses an unpaired electron. In this condition, that molecule has only one purpose in life and that is to oxidize other molecules by stealing an electron from them. Oxidation can cause untold damage to cell membranes, and also to other molecules that are vital to life, such as DNA. The end result is aging, and the onset of many diseases and conditions connected with aging. Free radicals are believed to be behind inflammatory diseases such as arthritis and Crohn’s disease, strokes, cardiovascular disease, Parkinson’s disease, Alzheimer’s disease and cancer among many others. Each of these is associated with aging. Free radicals are generated in the body in four different ways: 1. Energy is generated by the intercellular mitochondria by the production of ATP (adenosine triphosphate). By-products of the mechanism by which this is done include hydrogen peroxide, the superoxide anion, and a hydroxyl radical. Over 20 billion molecules of antioxidant are produced in each individual cell daily, and every one of these has the capability to do damage to your body. The figure for inefficient cell metabolism is significantly higher. 2. Peroxisomes are eukaryotic cell components that contain oxidative enzymes, whose function is to produce hydrogen peroxide that is then used by another enzyme, catalase, to oxidize other toxic substances. It is used by the liver, for example, to oxidize about a quarter of all the alcohol we drink to acetaldehyde, and also to remove other toxins from the body. The down side is that the hydrogen peroxide can escape and degrade the cell membranes. 3. Chronic infections give rise to a high activity of white blood cells, which utilize oxidants of various kinds to destroy viruses, bacteria and parasites. These include hydrogen peroxide, superoxide and nitric oxide which can also destroy the cells they are protecting. 4. Cytochrome P450 is an enzyme used to clear the body of toxic chemicals in our food such as pesticides and drugs. They also give rise to oxidative by-products. In addition to these, free radicals are also produced by air pollution consisting of smoking, factory emissions and traffic fumes. Trace metals such as lead, iron and copper, are rich free radical sources, as is the ultraviolet component of sunlight, and caffeine, from tea and coffee, can also contribute to the store of free radicals in your body. So where does green coffee extract come into this, and how should it be used. Free radicals tend to react very rapidly to accelerate aging, and in order to counter them, and hold the effects of aging at bay, it is necessary to destroy them almost as quickly as they are produced. This is carried out by antioxidants, of which there must be a plentiful supply available in each body cell. Antioxidants donate electrons to free radicals, and so effectively neutralize them before they can attack the membranes of the cells in your body, or any of the other tissues that they can degrade. Many of the vitamins have a powerful antioxidant effect, among them vitamins A, C and E. Other antioxidants available in our diet include beta carotene and other carotenoids, flavonoids and glutathione, and also cofactors such as lipoic acid. All of these can destroy free radicals by the donation of an electron. Green coffee beans have also been found to possess a strong antioxidant effect, due largely to the plant phenols, such as caffeic acid that forms chlorogenic acid with quinic acid, both cholorgenic and caffeic acid being string antioxidants. Green coffee bean extract is standardized to 99% chlorogenic acid. This substances not only reacts rapidly with free oxygen radicals but also helps to prevent to formation of hydroxyl radicals. It has been established that green coffee bean reacts twice as fast as green tea or grape seed extracts, and speed of reaction is critical in the destruction of free radicals that have to be destroyed before they do damage. Other antioxidants found in extracts of green coffee beans include heterocyclic compounds such as pyrroles, furans and maltol. The extract is made from beans of Coffea Arabica, this containing higher concentrations of chlorogenic and caffeic acids than the Arabica plant. The extract is also produced to be naturally low in caffeine, thus avoiding the negative effects of drinking coffee for its stimulating properties. When the green coffee bean is roasted, the antioxidant effect is found to decrease, and after roasting and brewing both the Arabica and the Robusta beans have reduced in activity to much the same level. Studies on some of the conditions exacerbated by free radicals have indicated the effectiveness of green coffee beans as an antioxidant. It is believed to help reduce atherosclerosis caused by the oxidation of low density lipids (LDL). Oxidized LDLs tend to be easily absorbed by phagocytes to form plaques and foam cells in artery walls, thus narrowing and hardening the arteries, causing a deprivation of oxygen and nutrients to the heart and also increased blood pressure. Antioxidants from the green coffee bean prevent this from happening, and so help to reduce this serious effect of aging. A good supply of antioxidants will also prevent the cell membranes from being destroyed, one effect of which is to age the skin. Antioxidants in the form of green coffee bean extract can help to maintain a youthful appearance while also aiding in the prevention of the more serious effects of free radicals that can shorten life. There are no doubts that free radicals contribute significantly to accelerated aging, and that the antioxidants contained in green coffee beans can help hold back the physical signs of aging, while also helping to destroy those free radicals that threaten life by promoting cancer, atherosclerosis, and other similar conditions.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1922) Grape Fruit Pectin Fiber
Date:
October 21, 2008 12:56 PM
Grapefruit pectin fiber is a source of soluble fiber that can bind to cholesterol and inhibit the formation of atherosclerosis. It is also effective in maintaining good blood sugar levels, and promoting a healthy colon. However, before discussing how grapefruit pectin fiber works in these ways, it is first necessary to explain how they occur in the first place. CHOLESTEROL LEVELS First cholesterol. This is a steroid lipid, most of which is biosynthesized by your body rather than being present in your diet. Although it has a bad name health wise, cholesterol is actually essential to good health because it helps your digestive system break down fast, it strengthens cell walls and is a major ingredient in the manufacture of vitamin D by your liver. It is also essential for the formation of several hormones, including cortisone, cortisol and aldosterone by the adrenal glands, and also of estrogen and testosterone. A bloodstream without cholesterol is therefore not good for you. Given that cholesterol is essential for good health, then why does it have such a bad press? The root cause of that is that cholesterol is not water soluble, and to be carried round the bloodstream to where it is needed it needs some transport. For that, it uses low density lipoproteins (LDLs). However, it’s not a return journey, and to get back they must use another form of lipid known as a high density lipoprotein (HDL). The protein part is water soluble, wile the lipid part can attach to the cholesterol and carry it around the bloodstream. The problem arises with free radicals, which are oxygenated molecules that are generated by the body’s metabolism, and also created from pollutants, such as pesticides and cigarette smoke, and the UV portion of daylight. These can oxidize the low density lipoproteins so that they can be attacked by phagocytes (while blood cells) deposited as plaques in the artery walls. This hardens and thickens the arteries, reducing the heart’s blood supply which in turn can cause strokes and heart attacks. This can be prevented in a number ways, the major of which are by consuming plenty antioxidants in your food, mostly contained in phytochemicals (plant chemicals), reducing your LDL cholesterol levels to the minimum needed by your body, and also by increasing the HDL levels in your bloodstream by as much as possible. Grapefruit pectin fiber can bind to cholesterol, and prevent it from being deposited in the artery walls by the oxidized LDL. A sixteen week double blind study (neither the subjects nor those carrying out the test and analyzing the results knew who were given the placebo) found that grapefruit pectin successful reduced the low density cholesterol level of 27 subjects by 10.8% and overall plasma cholesterol by 7.6%. These volunteers were at a medium to high risk of atherosclerosis due to a high LDL cholesterol concentration in their blood. Animal studies have also been carried out, whereby animals were fed a high cholesterol diet, and those fed a high fat diet were found to have an average of 45% narrowing of their arteries, and those fed the same diet, but with added grapefruit pectin fiber, were found to have only 25% narrowing, thus corresponding with the results of the human volunteers. BLOOD SUGAR It is essential that you maintain a stable level of sugar in your blood since the body reacts to low blood glucose by making you feel hungry, and thereby forcing you eat. If you are trying to lose weight you will find it very difficult if your blood sugar levels fluctuate. Grapefruit pectin can reduce the rate at which carbohydrates enter your bloodstream, and therefore the rate at which sugars are absorbed. Studies have also indicated that pectin can even out your blood sugar concentration, so that you experience fewer fluctuations or sudden spikes that can make you feel either very hungry, and so binge on carbohydrates, or very satisfied so that you eat nothing at all. The maintenance of a stable level of glucose in the blood is necessary for a normal life since it is that that determine your need to eat food. If your blood sugar is low, the desire to eat high calorie carbohydrate food is uncontrollable. This is the theory behind the so-called ‘grapefruit diet’. You eat a grapefruit prior to a meal, and allow it to be digested. The grapefruit pectin will make you feel full and so eat less, so that you can eat normal foods, but still lose weight. Many people take the grapefruit pectin in supplement form for its ease and economy of use. It is also more convenient since you don’t have to carry grapefruit around with you everywhere you go. A Healthy Colon Like any other soluble fiber, grapefruit pectin fiber is a dietary fiber that can help to maintain the health of your colon. In fact it is the only one of the basic four fibers of lignin, cellulose, hemicelluloses and pectin that is soluble. Although referred to as soluble, pectin softens and expands and provides substance and added weight to faeces in order to allow it to pass easier through your colon. Other than ensuring the easy passage of your stool through your colon, and avoiding constipation, grapefruit pectin fiber can help to prevent excessive growth of bad bacteria in the intestine, and because it accelerates the passage of substances through the colon, there is less time for toxic or cancerous substances to be in contact with your bowel lining. It is that which causes bowel cancer, and grapefruit pectin fiber can help to prevent it. Fiber can also help to prevent diverticulosis, where the intestinal wall develops small sacs and becomes weakened. It also prevents hemorrhoids, eases the symptoms of IBS (irritable bowel syndrome). In short, it offers many benefits for the health of your colon, and can help to cure many bowel conditions. However, it is important that you don't just rush into using any form of dietary fiber, but take it gradually. You start with a small intake, and then increase it slowly; since it is not absorbed through the intestine too much can lie in your colon and ferment, causing any number of intestinal problems. When used properly it can ease the symptoms of irritable bowel syndrome, but if used to excess, or too quickly, can actually cause the same symptoms, in addition to blocking the absorption of essential minerals such as iron, zinc and calcium.
Grapefruit pectin fiber can do a great deal for health, including maintaining good blood sugar and cholesterol levels, and helping to keep your colon healthy. It is available in convenient supplement form, but make sure that you drink sufficient liquid each day in order to prevent the fiber blocking your intestine rather than allowing free passage of waste product into, through, and out of your colon.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1921) Glycine
Date:
October 11, 2008 10:26 AM
The non-essential amino acid glycine is needed to generate muscle tissue and also for the conversion of blood glucose into energy. It is referred to as being ‘non-essential’ because the body can manufacture its own glycine, and is therefore not an essential component of your diet. Other uses to which glycine is put by the body includes the maintenance of a healthy nervous system, and is necessary for the proper functioning of the digestive system. Amino acids play three essential roles in the human body: 1. They are the building blocks of proteins: proteins comprise about half of the dry weight of the majority of your body cells, and without them there would be no life. They are produced using monomers known as amino acids, and there are about 20 different amino acids used to make the vast variety of proteins that make up the human body. Proteins are needed to form enzymes, the catalysts that permit the majority of chemical reactions within our bodies, and also genes, the building blocks of DNA. 2. More relevant here, amino acids play an important role in the production of ATP (adenosine triphosphate) from ADP (adenosine diphosphate) by phosphorylation with creatine phosphate. The more creatine phosphate available, the more ATP can be produced. Since ATP is the molecule responsible for the generation of energy, then the more ATP available the more energy is generated. Although creatine is available from many food sources, it is destroyed by cooking, and over half of what you use is made from the three amino acids, glycine, arginine and methionine. The energy produced in this way is very short-lived, and last only a few seconds - more on that later. 3. Glycine is heavily involved in the production of collagen, which is the substance that maintains the flexibility of your skin and other connective tissues while still maintaining their strength and firmness. Without glycine your skin would become slack due to the degrading effect of sunlight, free radicals and oxidation. The non essential amino acid, glycine, is believed to offer other benefits to the human body, but it is the second of those above, the production of ATP, which interests us here. ATP is an extremely important nanomolecule, second in importance to the body only to DNA, and possibly also RNA since the two are linked. RNA makes copies of your DNA structure for use in cell division and growth. When a cell expends energy for whatever reason, such as when I am typing this, or when your heart beats, or even when your liver synthesizes a protein, one of the phosphate groups is removed from the adenosine triphosphate molecule, and converts it to adenosine diphosphate (ADP). The ATP is then said to be 'spent', just as your energy is spent when you are tired and can exercise no more. The ADP is then immediately reconverted to ATP in the mitochondria, a part of every cell in your body. A cell can contain hundreds, or even thousands, of mitochondria, the number depending upon that particular cell's need for energy. Hence, cells in your muscles, or in your liver where most of the body's chemistry takes place, contain thousands of mitochondria whereas those in your scalp contain a lot less. Once changed to ATP, a phosphate is again lost when energy is expended, and so the cycle continues. Glucose is needed allow the ADP to be converted to ATP, hence the need for sugars, or the carbohydrates from which they are manufactured in your body. Each cell can contain up to a billion molecules of ATP, although the couch potatoes among you probably have a lot less! Your store of ATP molecules last about 2 to 5 seconds before being changed to ADP although more rapidly for athletes that expend a lot of energy. Then the energy stored in the form of glycogen in the liver kicks in for another 4 - 6 seconds. Additionally, you cannot expend more energy that the (eventual) sugars that you take in your diet, which can be in the form of ordinary 'sugar' (sucrose), fruit (fructose), glucose, carbohydrates that are metabolized into sugars, or any other member of the sugar family (e.g. lactose, maltose, etc.). Glycine is one of what are called glucogenic amino acids, which refers to their ability to provide glucose to the blood. Because it helps to maintain proper blood glucose levels, it is often prescribed for conditions that are caused by low glucose levels, such as hypoglycemia that shows symptoms of fatigue and tiredness, and also anemia and what is known as CFS (chronic fatigue syndrome). The one activity of the human body, in fact that of any mammal, for which ATP is essential, is the heartbeat. Without that no mammal could survive, or any other creature that relies on a circulation system for life. The only reason you heart has to beat is to pump your blood around your body, and it is your blood that contains the oxygen and nutrients needed to sustain life. Your cardiovascular health relies on lots of ATP being available to power each and every heartbeat. Analysis of the heart during the final stages of heart failure has revealed that there is a general decrease in the myocardial arginine: glycine amidinotraferase (AGAT) gene expression, which is indicative of the necessity of this enzyme for proper heart function. The enzyme is responsible for the first stage in the biosynthesis of creatine from glycine. Creatine is well known to athletes, and while it is available naturally from some food sources, it can be destroyed during cooking, and at least 50% of the creatine needed by the body is produced in the liver, pancreas and kidneys. It is creatine phosphate that is broken down into creatine and phosphate, the latter of which is used by the mitochondria to regenerate ATP from ADP.
The study carried out on the reduced AGAT levels found in heart failure patients indicates the importance of glycine to heart health. Without a good supply of glycine, there will insufficient creatine produced biochemically to generate the phosphate needed to for the ATP to produce the energy required to keep the heart pumping with the required strength. The energy provided by the mitochondria is used locally by the cells in which it is produced, and within a few seconds of that production. As explained earlier, ATP stores are used up within 2 - 5 seconds, and glycogen stores within another 4 - 6 seconds. That is why sprinters cannot keep running at maximum speed for more than around 10 seconds or so, because the immediate availability of glycine, and hence creatine, are insufficient to last longer than that. That is one reason why they have to finish those 100 meters as fast as possible, because otherwise they would run out of energy. Other than trying to win, of course! However, when it comes to the heart, ATP stores are essential, and the cells in your heart require a constant supply of ATP from creatine, which itself depends upon your intake or biosynthesis of glycine. Since dietary sources are insufficient to meet all your needs, and destroyed by cooking, a glycine supplement is the only way to ensure a sufficient intake. You cannot undernourish your heart and remain healthy.
ATP biosynthesis is essential if that of glycine theoretically is not, but the fact that 50% of your glycine requirement has to be produced by your body and the other 50% is sensitive to heat during cooking, a supplement of glycine could be essential to many people.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1912) Garcinia Cambogia
Date:
August 28, 2008 09:33 AM
Garcinia Cambogia is found naturally in India and parts of Asia, and also on the Pacific coast of South and Central America all the way from Peru up to Mexico, and likes a humid forested environment. Also known as Brindall berries, garcinia is believed to act as an appetite suppressant and allows you to lose weight by diminishing your desire for food. The Malabar tamarind, as it is also known, is about the size of an orange resembling a small pumpkin, and an extract from the fruit and rind is used in several weight loss products. The health risks presented by synthetic diet pills render a natural product extremely attractive were it to be effective. So can Garcia curb your appetite? What is the scientific evidence for it, and what biochemical route would it take? Although tests on animals have been very positive, human results have been inconsistent. In some double blind tests using a placebo, weight loss was up to three times that of the control, but in others there was no apparent difference between those taking garcinia, and those given a placebo. However, doubts have been raised of the validity of some of the negative tests, so what does science tell us? The active ingredient in the cambogia extract is hydroxycitric acid (HCA), which is a powerful inhibitor of ATP citrate lyase, an enzyme that catalyzes the reaction between citrate and Coenzyme A to Acetyl CoA and oxaloacetate. Since the acetyl CoA is necessary in the synthesis of fatty acids and lipogenesis (the conversion of glucose to fatty acids), then anything that inhibits the biosynthesis of acetyl CoA must help to reduce the amount of fat stored in your body. By inhibiting this reaction, that occurs outside the mitochondria so is not a direct part of the Citric Acid Cycle, HCA should theoretically suppress the formation of fats from carbohydrates, reduce food intake and thereby induce weight loss. But that is not the only mechanism. A study at Georgetown University in Washington found that after 8 weeks of taking the garcinia extract, there was a 5.4% reduction in body weight and body mass index, and a significant reduction in low density lipoproteins (LDL) and triglycerides with an associated rise in high density lipoproteins (HDL). This is good news for those suffering from high cholesterol levels, since the LDL lipoproteins are those that carry cholesterol to the major blood vessels, and which when oxidized by free radicals deposit fatty plaques on the artery walls. These plaques constrict the arteries and the resultant atherosclerosis can lead to cardiac problems and strokes. HDL lipoproteins carry cholesterol back to the liver for destruction, and is known popularly as ‘good cholesterol’. The studies also indicated modifications to certain indicators of the status of fat deposits in the body and of appetite modifiers in the brain. In this respect they found 38% decreases in serum leptin and increases in serotonin levels of 44%, and the excretion of fat metabolites in the urine increased from between 32% and 104%. These are significant findings, and further research has indicated that HCA helps to suppress appetite. Serum leptin is an indicator of the level of fat stores in the body, and as the leptin levels in the blood reduces, the hypothalamus is given an instruction to increase the appetite so as to increase the fat levels again. However, it is believed that HCA possesses leptin-like properties, and this signal is either not generated or is modulated. The increase in serotonin has the same effect. It is known that serotonin controls the appetite, although the exact mechanism has not yet been established. What is known is that serotonin activates certain neurons and melanocortin-4 receptors (MC4R) in the brain, that not only curb appetite but also block the effect of other neurons that would normally increase appetite by blocking the effect of MC4Rs. This is how the banned anti-obesity and serotonin inciting drug Fen-Phen operated, and it appears that the hydroxycitric acid in garcinia cambogia extract acts in a similar, but safer, way. The problem with drugs such as Feb-Phen was that they created cardiac problems which could be dangerous to obese people whose hearts might have been weakened. However, now that the biological pathway by which serotonin controls weight is believed to be known, if not fully understood, the way is becoming clearer as to how safer weight loss pills, acting through appetite suppression, might be developed. It also provides a valid scientific explanation for the effect of garcinia cambogia extract which might in itself prove to be that safer way. The biochemistry supports the evidence of its effect on those wanting to lose weight, and also bolsters the claims that those tests and trials found to be negative were in some way flawed. Until the full chemical pathway is understood, the factors that can lead to flawed tests are unknown, although one could be the use of excessive fiber in some trials that could reduce the effect of the extract. One of the effects of HCA is to limit the ability of your body to convert carbohydrates into fat (the Acetyl CoA inhibition mentioned above). That, combined with suppression of your appetite and a higher rate of thermogenesis, prevents the body from storing excess carbohydrates as fat. Instead you will have increased energy levels, so you should exercise to use this up while taking garcinia extract. For this reason it is popular with athletes and bodybuilders seeking an energy source that has not yet been banned from sport. Although diet pills based on the same principle had side-effects and could make the user feel on edge, there are none known with garcinia. However, it is possible to reduce the absorption of some essential nutrients due to appetite suppression, so do not exceed the recommended dose. An excessive amount can also led to gastric discomfort, but none of these effects have been noted when the recommended doses have been adhered to.
However, if you are diabetic, pregnant or a nursing mother, you should consult with your physician or health professional before taking the extract. Garcinia Cambogia presents no specific risk to such people, and this warning should be given for all non-prescriptive treatments that your physician might be unaware of you taking.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1876) Gac Fruit Oil
Date:
August 25, 2008 07:04 PM
Most people have never heard of gac fruit, yet it is very popular in South East Asia, particularly in China and Vietnam. The fruit is grown on vines that reach the size of a cantaloupe and from North East Australia across to China and Vietnam it is used as both a food and a medicine. It is only fairly recently that it has found use in the West as a health food So what’s so special about this fruit, known also as baby jackfruit and sweet gourd? Its bright red color should provide a clue, since it is jam packed full of beta carotene, lycopene and other strong antioxidants that not only helps to support the immune system, but also helps to retard the effects of aging. It has been used in Vietnam in particular to overcome the effects of an endemic deficiency in vitamin A, and is rich in provitamin A carotenoids. It is also widely used in Chinese medicine to treat a variety of complaints. Antioxidants and Free Radicals Antioxidants can boost health in a number of ways, and it might help you understand better the benefits that gac fruit can provide to explain what antioxidants do and why they are such an essential part of our diets. Every millisecond of every day of our lives, our natural metabolism of the conversion of blood glucose to energy generates small oxygenated molecules known as free radicals. Free radicals are molecules that possess an unpaired electron and are highly unstable. Electrons generally travel in pairs, and when one of that pair is lost through a chemical reaction, the other electron has only one purpose in its short life: to pair up with another electron and it will do whatever it has to in order to achieve that. It is called a free radical, and its life is short. Free radicals destroy body cells, and this can have a dramatic effect, both visually on your skin, and internally on your general health. Apart from those generated by your body’s own biochmemistry, free radicals are present in car emissions and other pollutants such as pesticides, smog and fried and barbecued foods. They are also formed in your skin by excessive exposure to the UV component of the sun’s radiation. That is why the skin of those living in hot climates tends to age earlier. Free radicals are what make you look older as you grow older: they destroy skin cells as they are formed, but that is one of the least of their effects. They can also oxidize low density lipids (LDL) that carry cholesterol around your body, causing it to deposit fatty plaques on the walls of your arteries, which is a serious cardiovascular condition known as atherosclerosis. Antioxidants can donate an electron to free radicals without then becoming free radicals themselves, and so destroy them as they are formed. However, the antioxidant can then lose its reducing power. Free radicals do not roam the blood seeking victims as many imagine them to, but react almost instantly, as soon as they are formed. It is important, therefore, that antioxidants are present in or close to every cell of your body. To achieve this, they must be bound to a fatty molecule, and the problem with many phytonutrients is that they have no associated fats or oils to carry them into the fatty tissues of the body. Nutritional Constituents of Gac Fruit Not so with gac fruit, because in addition to the beta carotene and lycopene content, it is also rich in long-chain fatty acids, particularly linoleic and alpha linoleic acids. Not only that, but its beta carotene content is around ten times that of carrots, and it contains 70 times the lycopene of tomatoes! Vitamin C is another very powerful antioxidant, and gac contains 60 times the Vitamin C of oranges. It is also rich in other free radical busters, such as xeoxanthins and alpha-tocopherol, a form of vitamin E. Altogether, gac fruit contains a free radical killing arsenal that should be enough to scare even the most courageous free radical back to where it came from. Other constituents of gac are numerous minerals, particularly zinc and iron. That is why the sweet gourd is such a prized fruit, and why Southeast Asian women have skins that western women of the same age would die for! Antioxidants help to prevent the disruption and destruction of skin cells that are the major reason for aging looks, and why skin creams are packed with vitamins A and E, both strong antioxidants. Health Benefits of Gac Most of the health benefits of gac are provided by its antioxidant properties. Thus, if you have a high cholesterol level, gac can help you to avoid atherosclerosis by preventing the oxidation of the LDL cholesterol, which is the precursor to it depositing on your artery walls. The body needs cholesterol, but levels should be kept to within certain limits or the resultant atherosclerosis can narrow your arteries leading to cardiac problems and strokes, particularly in the very narrow arteries of the brain. Gac also supports the immune system and helps to maintain prostate health, largely through its alpha tocopherol, or vitamin E content. Vitamin E is easily destroyed by free radicals, which is where the beta carotene is of benefit. This is the body’s first line of defense against free radicals, and each molecule can neutralize up to 20 free radical molecules before it is destroyed. This helps to save other antioxidants such as vitamin E. Lycopene is particularly beneficial to the prostate and current research indicates that it can help to prevent prostate cancer and cardiovascular disease, plus some other diseases such as macular degeneration that affects your sight. Perhaps this is one reason why the gac fruit membranes are used in Vietnam to promote healthy vision, and they also help to cure dry eyes. Lycopene remains in your body fat longer than normal beta carotene, and recent studies have found that men with high amounts of lycopene in their body fat are up to 50% less likely to suffer heart attacks as those with low amounts.
Gac fruit is jam-packed full of nutrients and antioxidants, and has no known side effects. It is used in Asia for weddings and other special occasions, and is grown on lattices in many gardens, although it has a short season. However, gac fruit is not known as the “Fruit from Heaven” for no reason, and if you were allowed the choice of only one fruit in your life, then this would be the one.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1874) Coconut Oil
Date:
August 18, 2008 12:01 PM
Whether coconut oil is good for weight loss or not, it is becoming an increasingly popular component of a weight loss diet. So how justified is this in view the fact that fats and oils are not normally regarded as being the best form of food to take if you want to lose weight? Apart from any other considerations, fats are actually very important components of any diet. Consider, for example, how many vitamins are fat soluble: vitamins A, D, E and K are all fat soluble, and without fats in your diet vitamins would not be able to circulate and be taken to where they do most good. Fats are also essential building blocks for hormones and cell membranes. In short, you cannot survive without fats. Coconut oil is a fat. In referring to coconut oil here, we are discussing virgin oil, not the refined form that is high in cholesterol. Refined, or processed coconut oils, is hydrogenated, which renders it more in nature to the longer chain fatty acids. Virgin coconut oil contains what are known as medium chain fatty acids (MCFA), which are easily metabolized by your liver into energy. The longer chain fatty acids, also called triglycerides, are not easily broken down into smaller components, and tend to be stored in the body as fat. This fat can be particularly dangerous if stored round the midriff, and so long chain fatty acids are dangerous to your health. This does not apply to MCFAs, and a possible mechanism for this is discussed later. An inability to distinguish between the different types of fats and oils in your diet is largely due to a lack of education in the chemistry of fats, and the lumping together of all fats and oils under the 'fatty' flag. Perhaps it is the use of the word 'fat' for the overweight condition and the fact that the triglycerides and other chemicals are known generically as 'fats' that triggers a connection between the two, but although this is logical, and in some cases justified, it is not always the case. There are fats and fats, just as there are lubricating oils and greases, and edible cooking oils and greases. The fatty acids in coconut oil are composed of relative small carbon chain lengths. Caprylic acid and capric acid contain 8 and 10 carbon atoms in the backbone compared to the 18 of the stearic acid that is commonly contained in animal fats. The longer the carbon chain in the molecule, the more difficult it is to break down, and the more likely it is to be stored in the body as a dense fatty deposit that places a strain on the heart. Due to the shorter chain length the medium chain fatty acids hold less energy per unit weight. Apart from any other reasons then, coconut oil contains fewer calories than other fats and so if used as the bulk of your fat requirement, will be less liable to generate body fat. Not only that, but as inferred earlier, due to the smaller molecule these calories are more readily released as energy for use by your body rather than stored unused. However, that is not the whole story on either count: coconut contains saturated fats, and also monounsaturated and polyunsaturated fats, although in small quantities. These, however, are present in only small amounts, although would still be expected to undergo oxidation and produce the rancid taste commonly found in aged unsaturated oils and fats. However, even after a year this does not happen, which indicates that coconut oil possesses some form of antioxidant properties. This is confirmed by the fact that people eating a diet rich in coconut oil has less of a need for the strong oil-soluble antioxidant vitamin E. In fact, the metabolism of fats is usually connected with the carnitine transport system in the mitochondria, although the shorter chain fatty acids do not need carnitine for their metabolism. What happens then is that because carnitine promotes oxidation during stress, and causes oxidative damage to body cells, its absence in metabolism of coconut oil fatty acids results in a reduction in the oxidation that degrades unsaturated fats. Hence the lack of rancidity. Taking this further, then, this lack of oxidation infers that those that take a diet rich in coconut oil (for example using it for cooking rather than animal and vegetable oils containing longer chain fatty acids) should be partially protected against cell oxidation in general. Oxidative effects such as aging, cardiovascular diseases and some cancers should be reduced, and studies have shown this to be the case. Those consuming coconut oil rather than other oils tend to age more slowly, suffer less from heart disease and tend to experience fewer incidences of cancer. With regard specifically to weight loss, it is believed that consumption of medium chain triglycerides, as opposed to longer chain triglycerides, results in a higher rate of thermogenesis, or the conversion of carbohydrates to energy (fats are also carbohydrates). The first step in this process requires the presence of Coenzyme A in the form of the enzyme acyl-CoA-dehydrogenase, and measurement of the activity of this enzyme has indicated that medium chain triglycerides exhibit much higher expenditure of energy than the metabolism of long chain triglycerides when being converted to fatty tissue. However, though the energy used up in this reaction, known as lipogenesis, was higher, the formation of fatty tissue was the same. Hence, MCA uses more energy to produce the same amount of fat as LCA, and therefore, although more energy is used up, no new fat is generated by the liver. Since your dietary fat intake can ultimately have only three fates: burned as energy, stored as the emergency energy source glycogen, or deposited as fat, then it is logical that the more energy generated then the less fat will be stored. In this way, coconut oil, with a high content of medium chain fatty acids, has a scientific explanation for causing weight reduction when used as a source of fat in the diet rather than animal or other vegetable fats or oils. It is converted to energy rather than fatty tissue, and if you exercise to use up that energy then your weight loss can be significant.
What this theory also states, however, is that coconut oil should be used as a replacement for other fats, and not in addition to it. If you take coconut oil in addition to your normal diet, do not expect to see results.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1870) What is Alpha Lipoic Acid?
Date:
July 18, 2008 12:36 PM
You can be sure that a supplement has some remarkable therapeutic possibilities when it makes headlines on the five o’clock news. A recent experiment which showed the conditions of rats that had been fed a diet that was totally deficient in vitamin E tested alpha lipoic acid, which caused the rats to return to full health even though no vitamin E was replenished. The results of this test are profound, as giving these rats an alpha lipoic acid caused existing stores of vitamin E that the body was previously unable to use to be regenerated. Alpha lipoic acid is a vitamin-like antioxidant that has been used in Europe for a long period of time. It has recently emerged as an extremely impressive therapeutic agent that scavenges free-radicals. Recent studies have suggested that it has the ability to stop some degenerative diseases, the oxidative process of aging, and restores the health of diseased organs. Additionally, it has the ability to make up deficits of vitamin E or C and could potentially be one of the best treatments that have emerged for diabetes. Alpha lipoic acid (ALA) is considered to be more potent than vitamins E and C, as well as coenzyme Q10. Unlike other antioxidants, ALA has properties that make it superior because it is able to replace certain nutritional supplements, while potentiating others, and inhibiting tissues from deterioration that is associated with diseases. This supplement is also both fat and water soluble, which allows it to protect lipid and aqueous cell structures. Alpha lipoic acid is a compound that is synthesized in small amounts in the body, but can also be supplied from food or supplement sources. A vitamin-like substance, it contains sulfur and also plays a crucial role in energy reactions. It can be found in liver, yeast, spinach, organ meats, broccoli, red potatoes, and red meat. When it is orally ingested, alpha lipoic acid is not compromised in the GI tract or the liver. Numerous studies have been conducted on ALA, all of which confirm its positive effect on metabolic processes, with recent clinical tests supporting its ability to enhance free-radical protection, slow the aging process, and guard against a variety of degenerative diseases. ALA was discovered in the 1930s, where it was originally classified as a vitamin, and later categorized as an essential coenzyme when scientists discovered that it was involved in the energy processes of cell mitochondria. It wasn’t until 1988 that scientists found that it also has powerful antioxidant effects. Alpha lipoic acid is important because it protects us from free-radicals which are present in a body as a result of the number of toxic substances such as auto exhaust, tobacco smoke, pollution, preservatives, and additives that we are exposed to on a daily basis. These free radicals can actually accelerate the aging process, causing premature tissue breakdown to occur. Additionally, our environment will continue to surround us with these pollutants that create free radicals.
There are things we can do to minimize our health risks, which include exercising, eating nutritiously, and not smoking. However, these measures are rarely enough to decrease our risk for certain degenerative disease a substantial amount. ALA is beneficial because it scavenges oxidants that are left behind and helps to convert carbohydrates, fatty acids and protein to energy that is needed to drive muscle movements.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1839) D-Ribose
Date:
May 17, 2008 10:07 AM
Discovered by Phoebus Levene in 1905, D-ribose is a monosaccharide, and is a component of RNA that is needed for genetic transcription. It is a stereoisomer of ribose, and although not regarded as an essential nutrient since it is synthesized in the body, it is essential for life. It also takes part in human metabolism, helping to generate energy from food, and is a component of all living cells – animal or vegetable. It is contained in ATP and NADH and we could not live without it. Because it is contained in all living organisms, D-ribose is a common component of the human diet, and required as a supplement only for specific needs. It for this reason that the human species developed and survived: the chemicals needed for life are either commonly found in nature or are manufactured by the body itself from other raw materials which themselves are common in our diet. The other stereoisomer is L-ribose, and this plays no part in human metabolism. Energy is needed not only to enable us to walk and to run, but also to drive every part of human physiological activity, and all of the physical and chemical processes of life. Because of its nature energy cannot travel round the body in our bloodstream as if were a chemical entity, but must be released or generated where and when it is needed. For that reason every cell in our body contains an area called the mitochondria in which energy is generated. The molecule of energy, if there is such a thing, is called ATP, or adenosine triphosphate. ATP controls the production of energy everywhere in the body, and allows muscles to contract and relax. This muscular activity is responsible for all movement, including the circulation of our blood through heart contractions, the diaphragm movement that creates the vacuum that allows us to breathe, and the operation of the digestive system by means of the peristaltic motion of the esophagus and the intestines. Each of the two ways in which ATP is generated involves D-ribose. One is by means of D-ribose being used to produce new ATP, and the other is the recycling of used ATP. In the latter, D-ribose and ATP react to form ADP (adenosine diphosphate and D-ribose-5-phosphate with the release of energy. This diphosphate then reacts again with the ADP to produce new ATP and D-ribose. The reaction is catalyzed by an enzyme known as a ribokinase, a phosphotransferase that specifically catalyzes reactions involving phosphorus groups with an alcohol receptor group. The heart muscle is operated by means of the calcium pump that depends upon both calcium and ATP for its operation. When ADP and phosphate are created by the effect of calcium and ATP coming together, then energy is provided to the muscle fibers of the heart. ADP then reacts with the phosphate and D-ribose in the presence of magnesium to reform the ATP. ATP is therefore essential for the continuation of the pumping action of the heart that maintains life in all mammals. D-ribose is also part of the base of RNA and DNA, without which there could be no life. Because the cardiac muscle is easily depleted of ATP, the presence of D-ribose is of extreme importance and it has been proved that cardiac failure begins with the reduction in energy levels of the heart muscle that can be brought about by a lack of ATP in the muscle cells. An important property of D-ribose is that it is unchanged by the liver, which is the chemical plant of your body in which a large part of the biochemistry needed for life takes place. This means that D-ribose can be taken in the diet and pass through the liver virtually unchanged, and then be transported in the bloodstream to where it is needed for the maintenance of ATP levels. That is why D-ribose is frequently given to treat heart attacks: because it can rapidly replace lost ATP and enable the calcium pump to get to work and keep the heart beating at its normal strength. Maintenance levels of this important sugar would not go amiss. However, there are other uses to which the body can put this marvelous substance. Among these is the body’s ability to form Coenzyme A from it. This coenzyme is needed in the body for the breakdown of fatty acids, and many other chemical reactions, and also provides the raw material for many other necessary substances in human biochemistry. Patients with low energy levels can frequently fail to be able to recover from illness. This is because that when illness stresses your body, your mitochondria become overwhelmed with work and begin to fail to produce sufficient ATP to keep the body going. Naturally, as your energy level drops, and your body cells are unable to respond to this, then the condition you are suffering from gets worse, and become stronger leading ultimately to possible death. Your immune system is put under a great deal of stress that uses up what little ATP you have left. That is why when people start to get really ill, they tend to fade very rapidly: not because of the spread of the disease, but through a reduction in the ATP needed to provide the energy required for the body to fight the disease. Without an adequate supply of energy, your body would rapidly fade. By taking a D-ribose supplement that passes unchanged right into your bloodstream and taken to where it is needed most, you body can rapidly generate sufficient ATP to keep up the fight against the agent that is making you ill. Your immune system is given a massive energy boost, and more importantly, your heart is kept beating. D-ribose is the answer to the prayer of many sick people, and also to athletes and bodybuilders needing quick bursts of energy. But what did they use before D-ribose was discovered to have the properties that it has? At one time, it was adenosine monophosphate (that’s right, not ATP or ADP, but AMP) that was administered intravenously to those suffering from chronic fatigue, this substance being synthesized to ATP in the body over a period of time. However, it take a lot of time to be effective, and the injections had to be made daily into the muscle tissue, so it fell out of favor. Then came an ATP supplement that could be taken orally, but the side effects were unpleasant, and that too went out of favor. However, towards the end of the 1990’s D-ribose was found to overcome all of these disadvantages, and not only be able to be taken orally, but also to work almost immediately by providing the mitochondria with a direct source of the sugar they need to generate energy. It is now one of the most popular energy providing supplements on the market, and also a remedy for chronic fatigue that helps the patient to overcome energy-sapping medical conditions both directly and by providing the immune system with the energy needed to keep it operating effectively against masses of invading bacteria and viruses. There is nothing better than D-ribose for providing you with the energy boost that you need, whenever you require it, either to provide energy for your sport or to help you overcome illness.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1792) Trace Minerals
Date:
May 09, 2008 11:09 AM
Colloidal trace minerals are just as important to our health and well being as vitamins. Practically since birth we have had it pounded into us that we must eat our vitamins if we are to be healthy. The fact is that vitamins are of little use to you without minerals which are as essential for your metabolism as any vitamin is. The essential minerals are the inorganic equivalents of the essential organic vitamins. They work together to maintain the biochemistry that keeps you alive. Take calcium, for example. That is a mineral needed for healthy teeth and bones, among many other things, but it is no good without vitamin D. Magnesium and potassium are also needed for healthy bones. Take blood clotting: vitamin K is the blood clotting vitamin, but blood will not clot without calcium. How is energy generated in your body from the carbohydrates and sugars that you eat? They are converted to glucose that is converted to energy in every cell in your body and used in-situ. Your heart gets the energy to beat from cells in the heart – energy does not float around the blood waiting to be used. It is generated by means of the production of a substance known as ATP – adenosine triphosphate of which phosphorus is an essential component. Without the mineral phosphate none of us would be alive – nor would any form of life for that matter. ATP is the universal molecule of life. So far we have discussed some of the seven major minerals: calcium, magnesium, potassium, phosphorus, sulfur, sodium and chlorine. There are many more that your body needs, and estimates vary from 45 to 70 trace minerals, without which you would find it difficult to function properly. Although your body can make many of the organic substances needed for life from vitamins, amino acids, fatty acids and proteins, it cannot make minerals which have to be taken in as part of your diet. They must be taken in your regular diet or as a supplement. In the USA a major mineral is one that is needed in amounts greater than 100 mg (0.1g) a day, and trace minerals are required at less than 100 mg a day. So one that is needed at 100.1 is major, and one at 99.9 mg is trace. Is there a difference in the source of trace minerals, or would any source be good enough? The answer lies in the construction of the human body, and the way in which it absorbs minerals. Your body is not designed to absorb metallic minerals. The way that such minerals are available in your diet is as part of larger organic molecules, and this is the way they must be taken as a supplement. Thus, you can’t just drink a soluble metal salt because it will pass straight through you with only around 5% absorption, if it doesn’t poison you first. For supplement purpose, metallic minerals are chelated, or combined with larger organic molecules such as proteins and amino acids, and this increases absorption to as high as 50%. The necessity of trace minerals in the human diet was not discovered, as much as the result of a number of studies on various societies and remedies that appeared to have no basis for their effects. The Hunzas and Azerbaijanis, for example, are known to live very long lives, and investigations into this showed their diet was very rich in colloidal trace minerals from glacial water and food grown in soil enriched by that water. It was through studies such as this and also investigation into the metabolites obtained from liver extracts that indicated the importance of many trace minerals. Take arsenic, for example. A known poison in larger quantities, trace quantities have been found to be metabolized by the liver, and while no studies have been carried out on the use of arsenic as a trace element in human biochemistry, studies on rats and human liver extracts have indicated that it could have a part to play in normal growth and reproduction. Trace minerals take part in many enzyme reactions, and physicians now agree that many health conditions could be enzymic in origin. It follows, then, that trace elements are important in maintaining good health. It is certainly true that we cannot live without any of the seven major minerals. And it is just as certain that many of the trace minerals are just as import to human biochemistry as the major ones. It is certainly true of vegetables, which are less complex biological entities than humans, and if tomatoes need at least eight known minerals for good growth then it is certain that we will need a lot more. No studies are needed to convince us of that. Take zinc, for example. Zinc is essential for proper liver function, wound healing and reproduction: spermatogenesis, the proper development of the primary and secondary male sex organs, and all area of the female reproduction process. Zinc is classed as a trace element, as is selenium, a deficiency of which can lead to heart disease, mental retardation and impaired function of the thyroid. Selenium deficiency is not common in the West but is in China where many areas are depleted of selenium. However, if zinc and selenium are known to be essential, how many of the other seventy or so trace minerals are also essential to human health? The trace minerals in general are believed to protect us from some degenerative conditions, the effects of environmental pollution and help to protect us from the effects of an excessive intake of toxic minerals. Although there have been insufficient studies carried out on most trace minerals, it is known that they should be taken in chelated form, metallic in nature or not. It is also known that such minerals should be taken as a balanced mixture as found in nature. A bullet approach, using an individual mineral to treat a certain condition, could lead to an imbalance in the body, and severe side effects, some of which might not yet be known. What is known is that certain minerals are tolerated by each other in specific relative concentrations, but if this balance is upset then they can inter-react and produce unpleasant side effects on, for example, the delicate balance of minerals in the blood. It is becoming increasingly clear that modern farming methods have resulted in mineral depletion of the soil, and that our normal diet now only contains a small number of the minerals that our forefathers were taking. Plants draw up minerals from the soil when they grow, and we take in these when we consume them or the animals that live on them. Saturation of the soil year in year out by chemical fertilizers low in or devoid of trace minerals has resulted in a sterile environment for our feedstock, and has made colloidal trace mineral supplements almost mandatory for good health. Today’s plants can contain fewer than 20 minerals, compared to the 70 plus of our ancestors. Life expectancy is increasing in spite of our increasingly poor diet rather than because of it, and is due more to medical advances than to advances in agriculture. A mineral supplement does seem necessary, but when you take one it should be balanced so that no one mineral is in excess at the expense of another. This helps to reduce the possibility of overdosing on an individual substance while maintaining a natural balance of minerals in your body to make sure that your normal biochemistry is not interrupted by some deficiency or excess that has yet to be discovered. While this might seem a spurious argument, you can be certain that those in the past that used cadmium and lead as cosmetics would rather have known the effects of these toxic substances that eventually killed them.
So use chelated trace mineral by all means, but make sure that they are balanced and tested so that nothing is present that can upset the normal balance of minerals in your body. If they work for tomatoes they should work for you!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1786) Cherry Fruit Extract
Date:
April 28, 2008 02:45 PM
Cherry fruit extract contains organic compounds known as flavanoids, which is a form of phytochemical frequently found in highly colored fruits and vegetables. If you eat a fruit such as pomegranate, blueberry, blackberry or cherry, or if you eat red peppers, aubergines and broccoli, you are eating foods that are rich in flavanoids. Such foods provide you with remarkable health benefits that your ancestors knew about but did not understand. They ate these highly colored foods because they knew they helped prevent certain medical conditions, and to help others get well faster. They knew nothing about phytochemicals – chemicals contained in plants – or flavanoids, but knew about the results of eating them. In fact, flavanoids are very powerful antioxidants and anti-inflammatories, and each of these require more detailed explanation since between them, oxidants and inflammation are responsible for most of the non-infectious common ailments of the human body. First, let’s have a look at antioxidants. In chemical terms oxidation is the removal of an electron from an atom or molecule. There are species within your body known as free radicals whose sole purpose in their short life is to steal an electron from the nearest molecule to them. This is almost instantaneous, and most free radicals are very short lived. The concept of free radicals roaming your body and your bloodstream waiting to pounce on the first unwary molecule is a fairy tale. In fact the vast majority react as soon as they are formed. When they do react, they remove an electron from a stable molecule, render it unstable and thus destroy it. If that molecule is part of a cell, and enough of them are robbed of their electrons, then the cell is destroyed. One result in visible terms is wrinkling of your skin, as your skin cells become destroyed, and hence you age quicker. In terms that you are not immediately aware of, oxidation can lead to many unwanted changes in your body. For example, the low density lipids, that carry the cholesterol in your blood to areas of the body where it is needed, are oxidized by free radicals which causes the LDL to deposit along with their cholesterol on the walls of your arteries as a layer of plaque. Eventually that will build up to constrict the artery and cause a condition known as atherosclerosis – the arteries become blocked, and you can suffer from heart attacks and strokes. These free radicals are formed by the normal metabolism of the body when energy is created in the cell mitochondria, by pollutants such as pesticides, cigarette smoke and traffic fumes, and by radiation such as excessive exposure to the UV radiation in sunlight. Flavanoids, contained in cherry fruit extract, are antioxidants, which prevent this oxidation of body cells from taking place. They do so by being in the right place at the right time. If a flavanoid molecule is close to a free radical when it is generated, then the antioxidant will reduce the free radical and neutralize it. If you eat a lot of cherries, or drink cherry fruit extract, you will be consuming a massive amount of flavanoids molecules that are ready and willing to destroy these free radicals. However, that is not all that flavanoids do. They are also, as has already been stated, anti-inflammatories. The inflammatory response is the reaction of the body to a foreign presence such as bacteria. The tissues around the infected area receive an increased blood supply, and the cell walls produce gaps allowing the large immune system blood cells, or macrophages, to pass through. The temperature around the area increases due to the concentration of blood, and this itself is controlled by the body since bacteria die off after a certain body temperature has been reached, hence the reason for fever in the immune response. The area swells up due to the concentration of fluid and protein, and becomes painful due to pressure on nerve endings. Anti-inflammatories, such as the flavanoids, work to relieve the symptoms of inflammation without interfering with the way the immune system deals with infection. Many inflammatory conditions occur without any apparent reason, and while anti-inflammatories might not be used to suppress the immune system, it is used in such conditions as rheumatoid arthritis where the inflammation is a mis-firing of the immune system. Cherry fruit extract can be used to alleviate many similar conditions such as gout, and osteoarthritis where its use is well known and recorded. It can also be used to help reduce the effects of atherosclerosis through its anti-oxidant properties, and cherries contain, not only a good supply of flavanoids, but also anthocyanins, another group of powerful antioxidants. They also contain vitamin C which is also a strong antioxidant. Another property of flavanoids is their collagen strengthening properties, which they achieve by cross-linking the fibers to form a string fibrous network. That can be used to strengthen the walls of veins, and render them less liable to stretch or expand, thus providing them with the rigidity needed to prevent varicose veins caused by the puddling of blood below weak valves. They have the same effect on arteries, providing increased strength and a reduction in the blood pressure needed to pump blood round the body. A good intake of cherry fruit in your diet will help to improve the condition of your cartilage and other connective tissue in addition to your veins and arteries, and is particularly appropriate for athletes who place great stresses on connective tissues such as the tendons that transfer muscular energy to the levers – the long bones. In summary, then, cherry fruit extract and the flavanoids and anthocyanins it contains, posses properties to help relieve the symptoms of gout, and various forms of arthritis, to reduce the likelihood of cholesterol oxidation that leads to heart disease and strokes, to help strengthen the walls of veins and arteries and to improve the strength of connective tissue such as cartilage and tendons.
In other words, to improve the quality of life of the majority of the population that suffers from one or more of these conditions. After learning about the health benefits of cherries and all the mounting evidence in research, my question to you is why did the FDA make cherry farmers pull the health benefits of cherries from their websites with threats of legal action if not removed? Makes a person wonder who is on our side and who isn’t?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1775) Bilberry Extract Is A Powerful Antioxidant That Strengthens Veins
Date:
April 12, 2008 11:06 AM
Bilberry extract is taken from the Vaccinium myrtillus, or bilberry, a small blue berry that has been used traditionally for the treatment of conditions now known to be due to inflammation and the action of free radicals on the body. Among these is atherosclerosis, or hardening of the arteries, caused by the free radical oxidation of the low density lipids that carry cholesterol around the bloodstream, and that cause deposition of fatty plaques on the arterial walls and eventually constricts them to a stage that can cause heart failure or a stroke, depending on whether the arteries are close to the heart or in the brain. However, additional to treating this condition, bilberry has also traditionally been used for the treatment of varicose veins and also for certain eye conditions. In fact it was during the Second World war that the Royal Air Force in Britain received reports from pilots that their night vision improved after eating bilberries. Not only their vision, but the restoration of night vision after exposure to glare. This was extremely important to war-time pilots who had to be able to rapidly adapt their vision to fly their plane after exposure to searchlights and explosive detonations. That is the reason for anything that appeared to promote this essential adaptation to be reported. The pharmacology of these effects have been found to be due to the anthocyanosides in which bilberries are particularly rich. Anthocyanosides consist of an anthocyanaidin backbone, to which one of either arabinose, galactose or glucose can be bound. Since bilberry contains five of these anthocyanadins, then there are fifteen different anthocyanosides in the fruit concentrate. The area of the retina that appears to control night vision, and the transition from day to night sight, is called the epithelium which is connected with purple vision. Anthocyanosides seem to have an affinity for this part of the retina, and in so doing plays an important part in this type of vision, specifically night vision although it is also beneficial in improving day vision. Although bilberry also contains vitamins A and C, hydroquinone and tannins, it is the anthocyanosides that provide it with its unique antioxidant properties, and also its effect upon collagen fibers. It can cross-link collagen fibers to help overcome weaknesses in the connective tissues such as cartilage, tendons and the walls of blood vessels. Its effect as an antioxidant is to prevent the cleavage of collagen by the cyzymes that are secreted by leukocytes generated by the immune system. By preventing histamine release, and release of prostaglandins and other proteins and cells mobilized during the immune inflammatory response to the detection of foreign invasion into human tissue, anthocyanosides can help to reduce inflammation and to protect against other extreme reactions of the immune system that can harm the organism it evolved to protect. The most powerful property of anthocyanosides are their antioxidant properties: perhaps even its only property once all of the conditions it helps to protect against are fully understood. An antioxidant combines with free radicals and destroys them. Free radicals are particularly vile chemical entities that require an electron to make them stable, and they take this electron from the nearest source. This can result in oxidation and destruction of many bodily tissues leading to premature aging, atherosclerosis, eye damage and many other problems that result from the destruction of body cells and tissue. The various constituents that make up bilberry act in concert to scavenge the free radicals and increase the supply of oxygen to the eye. The benefits of this are in helping to prevent cataracts and glaucoma, the latter due to the effect of the anthocyanoside cross-linking effect on the structure of the collagen in the eye. It can also help in cases of macular degeneration that affects the central area of the retina which might be due to the same property of there glucoside. Moving away from the eyes and back to the vascular system, the collagen cross-linking properties of the flavonoids, which is what anthocyanosides basically are, can help to repair damaged vein tissue by strengthening the vein walls themselves, and also by providing support for the cell membranes, or outer layers of the cells. This in turn builds up more strength in the vein tissue below the outside walls and contributes to an overall reduction in the weakness of the vein. This in turn enables it better to withstand the internal pressure put upon it by the failure of the valve that created the problem. In this way bilberries can be used to help repair the damage done by varicose veins and improve the function of the vein in returning blood to the heart from the extremities of the legs and also to help reduce the pain and swelling of varicose veins. In addition to these beneficial effects on the vascular system and the eyes, bilberry can also help to decrease the permeability of the blood-brain barrier to pollutants, drugs and other undesirable chemicals by improving the resistance of the capillaries in the brain to the transfer of such substances through their walls. It does so by preventing the collagen of the capillaries in the brain being degraded either by enzymes or other agents, Also, by helping to strengthen that collagen structure so that it becomes more impermeable to the larger molecules that form the pollutants. A lesser known constituent of bilberry is myrtillin, an anthocyanoside monoglucoside that is also available in all green plants, that possesses anti-glycemic properties. What this means is that it can reduce hyperglycemia and glycosurea, and so reduce blood sugar without reducing the blood sugar level to dangerously low levels. In other words it is an ideal insulin substitute. Native Americans used green plants for teas for centuries and were free from diabetes until the came into contact with Europeans and adopted their dietary habits. Although the case has to be proved, it appears highly likely that it was the myrtillin that kept them free from a condition that affects so many other races. Irrespective of that, however, it is for its powerful antioxidant effect that bilberry finds its best use, and also its effects on varicose veins. However, all of the above health benefits that bilberry provides, can likely be laid at the door of the combined antioxidant effect of its vitamin C content and the anthocyanosides – including the glucoside myrtillin.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1753) Ubiquinol Reduced CoQ10
Date:
April 07, 2008 01:05 PM
Ubiquinol, which is the reduced from of Coenzyme Q10 (CoQ10), has been recently added to the supplement offerings of many companies and has generated a lot of confusion along with its excitement. As a supplement, ubiquinol is somewhat new, but as a critical part of human metabolism, our knowledge of ubiquinol goes back to the discovery of CoQ10. Although CoQ10 is often thought of as a “static” nutrient in the context of nutrition, it actually interchanges between two useful states: the oxidized ubiquinone, and the reduced ubiquinol. Coenzyme Q10 is a member of a family of important biological compounds which are referred to as ubiquinones. It is a lipophilic, water-insoluble substance, which takes part in a large array of biochemical oxidation and reduction reactions. It was first identified in 1957 as an essential component of the energy production system in cells. CoQ10 and other members of the ubiquinone family have, since then, been identified as critical metabolic compounds in a range of aerobic organisms. Because of its crucial role in metabolism, humans have the ability to make their own CoQ10, although small amounts can be obtained through diet and as supplements. In humans, CoQ10 is found in each cell in the body, but is particularly abundant in tissues which have large energy requirements such as the heart, liver, kidneys, and skeletal muscles. Smaller amounts can be found in the brain, lungs, and intestines. There are also substantial amounts that can be found in circulation, which are most often associated with lipoprotein particles. In total, CoQ10 in a normal adult has been estimated to be between 0.5 and 1.5 grams. Inside cells, about half of the CoQ10 is found within the mitochondria, where the final steps of CoQ10 production occur. CoQ10 which is not located in areas of the cell and are not charge with producing cellular energy can amount to about 50-60 percent of the total CoQ10 pool. CoQ10 can be found throughout cell membranes and in other cellular structures such as the nucleus, cytoplasm, and endoplasmic reticulum. Some experimentation has also concluded that, while the final steps of CoQ10 production occur in the mitochondria, it can be exported to other sub-cellular locations. While participating in various oxidation and reduction reactions, CoQ10 is cycled between two stable states: a fully oxidized form referred to as ubiquinone, and a fully reduced form called ubiquinol. CoQ10 cycles through these oxidated/reduced forms in order to achieve its metabolic goals. The cycle of CoQ10 is simple. Ubiquinone picks up electrons and then becomes ubiquinol. Ubiquinol then release its electrons and becomes ubiquinone again. Therefore, it would seem that CoQ10 has a very simple function of moving electrons, as the transfer of electrons is a fundamental step in the production of energy, the regeneration of antioxidants in cell membranes, and the construction of other important biological molecules. Each cell that is in the body needs a source of energy in order to survive. Therefore, sugars, fats, and amino acids are broken down in order to make energy. In the mitochondria, CoQ10 is abundant, as it carries electrons to aid in the chemical reactions that burn cellular fuel and produce chemical energy to form ATP. Since substantial amounts of ATP are needed to power our cells, the importance of CoQ10 in human metabolism is easily understood. Both forms of CoQ10 are needed to transfer electrons between energy-producing reactions. Outside of the mitochondria, CoQ10 performs a slightly different role as a membrane and antioxidant. About half of the human body’s total CoQ10 pool may be functioning in this capacity. CoQ10 is one of the major antioxidant elements of the LDL particles and is also one of the first to be depleted when LDL is subjected to oxidation. A discussion of CoQ10 would not be complete without mentioning its documented health benefits. Supplemental CoQ10 has been the subject of a lot of studies over the last half century, especially in applications for cardiovascular health. Many studies have shown benefits of CoQ10 in patients who are diagnosed with chronic heart failure, exercise-induced angina, hypertension, or those who have recently experienced infarction. There is also early evidence showing that CoQ10 may protect the heart from damage during chemotherapy, bypass surgery, or in diabetes. Aside from its cardiovascular uses, CoQ10 has been studied for its benefits in other conditions involving dysfunctions in cellular energetics, neurological degeneration, or oxidative stress damage. Although the clinical evidence for the potential benefit of CoQ10 in many of these applications shows promise, the variability in study outcomes proves it necessary to further research these areas for a more definite answer. As we have previously seen, CoQ10 functions by cycling between two stable forms, ubiquinol and ubiquinone. This cycle results in the generation of cellular energy and the protection of membranes and lipids from oxidation. Dietary or supplemental CoQ10 also takes part in this cycle. Supplemental ubiquinol may have a distinct advantage over ubiquinone in its facility of absorption. Like many fats and lipophilic nutrients, CoQ10 is usually taken up by the intestinal electrolytes, packaged into lipid particles, and then released into the lymphatic system. From there, these particles are transferred into circulation where they are free to be transported throughout the body as needed. The absorption of dietary CoQ10 is actually quite poor since it has limited solubility in lipids and depends on other contents of the gut. Some studies have measured that absorption is as low as 2-3 percent of the total dosage. One of the most thrilling consequences of the development of a stabilized dosage form of ubiquinol is its ability to be absorbed more efficiently than ubiquinone. There is evidence that CoQ10 must be reduced in intestinal enterocytes before the release into the lymphatic system. This, paired with absorption/reduction, may be a rate-limiting step of CoQ10 assimilation. Dietary ubiquinol avoids this reduction reaction, and is directly available for absorption, which explains why ubiquinol-based CoQ10 supplements exhibit enhanced bioavailability over ubiquinone supplements. Preliminary studies in humans have shown that absorption of ubiquinol is at least double the absorption of ubiquinone. Comparisons of blood levels between trials also estimate the improvement in absorption to be significantly higher. Future studies are necessary to more accurately determine ubiquinol’s enhanced absorption, and what effect the patient age or medical condition may have on these results.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1743) Beta Carotene Is The Safe To The Liver Form Of Vitamin A
Date:
March 19, 2008 08:17 AM
The fact that beta carotene is stated to be a safe form of vitamin A suggests that vitamin A is in some way unsafe. In fact an overdose of vitamin A can lead to any one of a number of conditions, including nausea, jaundice, vomiting, abdominal pain and headaches. This vitamin is fat soluble, and so any excess is not easily washed out of the body but can build up in the tissues. Toxicity in the liver can occur at fairly low concentrations, and the toxicity of the vitamin is increased by excessive alcohol intake. However, toxicity only occurs with vitamin A already formed such as that obtained from liver. There are several forms of vitamin A, including the retinoid form originating from animal sources and the carotenoid forms that have a vegetable origin. Carotenoids are converted to vitamin A in the liver, but the higher the concentration of beta carotene in the body, the smaller the percentage that is converted to vitamin A, so beta carotene is a safer source of vitamin A than retinoids. It is only the finished form of vitamin A that is toxic, and beta carotene is therefore self-regulating in its production. This vitamin is stored in the body in the form of the alcohol (retinol) and of retinyl esters. Studies have indicated that as much as 95% if the stored vitamin is in the form of the ester. The liver is responsible for releasing vitamin A to the body as it is required. One of its better known effects is on vision, and the old wives tale that carrots help you to see in the dark has an element of truth in it. In order for it to aid vision, retinol is oxidized to the aldehyde, retinal, that forms a complex with a molecule of opsin, a light sensitive protein found in the retina. Rhodopsin, as the complex is called, is an essential component of the biochemical chain of events that lead to the perception of light. It is extremely sensitive, and enables you see in very low levels of light. In other words it is essential for good night vision, so carrots do help you to see in the dark! When a photon of light hits a molecule of rhodopsin, it leads eventually to an impulse being sent up the optic nerve to the brain. One of its properties is its reaction to white light. When rhodopsin is exposed to white light it loses its pigmentation, and hence its photoreceptor properties and can take 30 minutes to regenerate. That is why you lose your night sight if your retina is exposed to bright light. The more rhodopsin you can generate the quicker you develop night sight. The other biochemical processes of the vitamin include the synthesis of some glycoproteins and maintenance of normal bone density. Without vitamin A, calcium is not properly absorbed by the body and glycoproteins are involved in this process. A deficiency of vitamin A can lead to the abnormal development of bone and other health problems, so there are limits between the levels of vitamin A in the body that must be maintained: above or below these limits will lead to health problems, some of which can be extremely serious. Most of the biochemistry of vitamin A in the liver is initiated by the presence of alcohol, and otherwise it is though to passively store the vitamin until needed when it is released into the blood. There are several ways in which the presence of alcohol allows the liver to deplete its store of retinol, but generally there are a number of enzymes that, in the presence of ethanol, can render vitamin A into a water soluble form that is excreted by the urine. The benefits of vitamin A other than its effect on night sight and the healthy development of bone tissue, includes a powerful antioxidant effect that neutralizes free radicals that can destroy body cells. These free radicals are generated by the body’s metabolism in generating energy from blood glucose, and are also created through exposure to pollutants such as cigarette smoke and traffic fumes. They are electron deficient, so when they are generated they grab an electron from tissue close by which destroys the cells involved. This can lead not only to the appearance of premature aging as the skin cells are damaged but also to serious health problems such as atherosclerosis and some forms of cancer. Vitamin A helps to protect against these by destroying the free radicals before they can do damage. It also helps build up resistance against infections by supporting the immune system. Beta carotene is converted to vitamin A either by cleaving at the center of the molecule, or by breaking it down from one of the ends. This latter process is carried out in the small intestine, and the resultant vitamin stored in the liver in the ester form. Only a proportion of what you eat is converted to retinol ester in this way, and the more beta carotene you consume, the less is converted, so you can never suffer from an overdose of beta carotene-derived vitamin A. It might turn you yellow, but you won’t suffer from excess vitamin A since the excess beta carotene is stored in your body fat, including the subcutaneous fat reserves. Alpha carotene can also be used in the synthesis of vitamin A, but not as actively as beta carotene. The best natural sources are fruits and vegetables, especially the red, yellow and orange varieties such as carrots and apricots, and also the leafy green vegetables, although supplements are also a convenient way of maintaining your beta carotene uptake. It is a much safer supplement than straight vitamin A for the reasons explained earlier. The supplement is not useful just for its antioxidant effect, but also for its ability to protect you from excessive exposure to the sun. While not as effective as a good sun blocker, beta carotene does provide some protection. There is no doubt that beta carotene is a safer way to maintain an adequate vitamin A uptake due to the fact that you cannot take an overdose, since an overdose of beta carotene does not translate into the same dose of vitamin A, and the change is self-regulating. It is therefore safer to obtain your vitamin A needs from colored fruits and vegetables or beta carotene supplements than from eating liver, from which the retinol is in a form that can cause damage in the event of consuming an excess. The old adage that you should never eat polar bear livers is a true one, and certainly has a provable scientific basis, so use beta carotene as your main vitamin A source for maximum health benefits in the safest possible way.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1725) Astaxanthin, a Member of the Carotenoid Family, is a Powerful Antioxidant
Date:
January 31, 2008 09:00 AM
Astaxanthin is a member of the carotenoid family responsible for the red color of many types of algae. Being a carotenoid, it is a powerful antioxidant and free radical scavenger as well as support proper eye function. However, such a bland statement belies the true worth of astaxanthin in its fight against free radicals. It is of particular benefit in its ability to absorb the high energy of singlet oxygen, releasing it as heat, and returning the singlet oxygen to its ground neutralized state. Singlet oxygen is a particularly harmful and reactive oxygen species of free radical that is formed in the body as part of our normal metabolism, and that contains a high level of free energy that can be used to oxidize and destroy the cells of your body. In achieving this, astaxanthin is regarded as one of the most potent plant derived antioxidants known, being up to ten times more active than beta carotene, Lutein or its cousin canthaxanthin. So why are antioxidants so valuable to our biochemistry and what would happen if they did not exist? Free radicals are thieves that use your body as their operating ground. They operate by stealing an electron from a molecule that comprises part of you, and in some cases when this occurs the cell from which the electron is removed is destroyed. Generally electrons go around in pairs, but occasionally an electron pair can lose one of the electrons during a chemical reaction. Many such reactions occur naturally inside the body, especially during the production of energy from blood sugars in the mitochondria, and such a molecule containing a single unpaired electron is called a free radical. Free radicals are also generated by the reactive components of many pollutants such as traffic fumes and cigarette smoke, tars and pesticides, and also by the effect of UV radiation in sunlight. The only purpose of a free radical is to steal an electron from the first source it can find. Such reactions occur very rapidly after the free radical has been generated, and if this electron belongs to another body cell, then the cell is destroyed leading to effects such as premature aging or even cancers. Free radical oxidation of the LDL lipids that carry cholesterol around the blood causes the deposition of fatty plaques inside arterial walls that eventually become constricted or even blocked, leading to heart disease or strokes. That is why antioxidants that destroy these free radicals are so prized, and the more of them that there are in your body then the less affect the free radicals will have on you. You will retain your youthful looks longer, and will be less liable to suffer from heart disease, cancers, circulation problems and conditions such as diabetes. Many abnormal conditions can be laid at the door of free radicals. The stronger the free radical, the more harm it can do to you and a strong antioxidant such as astaxanthin is a very powerful weapon in your armory against them. Astaxanthin is a member of the oxygenated xanthophylls, and its high level of antioxidant power likely comes from the ketonic and hydroxyl functional groups of the ionone ring structure. It is more polar than most carotenoids, and this is a likely reason for its ability to span the cell membrane layers, with the active groups close to the hydrophilic-hydrophobic interface. They are thus more readily available at the sites where most free radicals tend to be found and provide immediate protection to the cell membrane and also to the intracellular mitochondrial membrane. Many antioxidants destroy free radicals by donating an electron, and become oxidized themselves. Astaxanthin, however, does not do this, but instead adds the free radicals to its long double bonded chain hence avoiding oxidation and rendering it much more powerful than normal antioxidants. It is unusual among antioxidants in that it is also able to cross the blood-brain barrier, and so reduces oxidative stress that can cause neurological disorders in general, and also problems with eyesight. It can also attach itself to lipoproteins to enable it to be carried throughout the bloodstream, being available anywhere that free radicals are generated. The carotenoid is also active against active oxygen species that are responsible for inflammation. Another property is its ability to neutralize the oxygenated free radicals formed by the photo-oxidation properties of UVA and UVB radiation. Included in these are the previously mentioned highly reactive singlet oxygen and also triplet oxygen that astaxanthin is able to neutralize without becoming oxidized. In fact reactive oxygen species in general can cause oxidative stress, and they have been thought responsible for many forms of disease and health conditions, and the powerful effect of astaxanthin in targeting many of these has led it to be regarded as highly beneficial to the immune system and to health in general. Another benefit is the ability of the substance to help prevent the oxidation of high density lipoproteins (HDL) that are responsible for carrying cholesterol in the blood back to the liver for destruction. Free radical oxidation of HDL impairs its ability to transport cholesterol, and so decreasing the level of such free radical oxidation will by definition increase the quantity of good HDL available, and hence reduce the concentration of cholesterol in the blood. Studies have proved this to be the case, and astaxanthin supplements are very beneficial to those suffering from high blood cholesterol levels, and helps protect them from heart disease and strokes. The substance is naturally available from a wide range of marine sources, such as lobsters (where it was first discovered), shrimp, salmon, trout and in a wide variety of red and green algae. The substance is also used as a red pigment. Carotenoids are essential, meaning that they are not produced in the human body and can only be obtained in our diets. For that reason, the most convenient way to take it, apart from continually eating shrimp and lobster, is as a supplement. Astaxanthin is available either as a powerful antioxidant in its own right, or in combination with other substances with which it acts to provide a very strong deterrent to any free radicals that think they can freely roam your body.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1711) You Should Say: Please Pass the Broccoli, Not I’ll Pass
Date:
January 22, 2008 04:38 PM
'Please pass the broccoli': not something that many mothers hear from their children. In fact, not many children appear to like any green vegetables let alone broccoli. This is not important at such a young age, but there comes a time when the health benefits that broccoli brings become almost essential to your good health and well being. Parents are right, but your children won’t believe you. Some say that the nutritional punch of broccoli is stronger than that of any other vegetable. Is this claim justified? Let’s have a look at the evidence and the facts and you can judge for yourself. First the ‘ordinary’ nutrients of broccoli: vitamin C (more than oranges) and A, folic acid and calcium and also lots and lots of fiber. However, this wonderful vegetable contains not only high levels of calcium, but is also the one of the richest vegetable sources of magnesium. Calcium needs magnesium in order to be properly incorporated into your bone structure, and so broccoli is a very important calcium/magnesium source for vegans that do not drink milk or eat any other dairy products. It is also rich in protein, containing 3% by weight and is also rich in iron. It is therefore an important part of the diet of women during menstruation when iron is important to enable the blood to maintain its proper erythrocyte levels. A deficiency of iron in the diet of women can lead to anemia and render them more susceptible to infection. However, it is more than just iron that renders this vegetable an important part of the female diet. Broccoli has been established to be of major importance in preventing cancer. It is likely the most potent anti-cancer vegetable in your diet, and it has been established over 20 years of study that broccoli can help to prevent cancers of the breast and the cervix. The indoles that it contains prevent estrogens from promoting tumor growth, and it also contains beta-carotene, a strong antioxidant that destroys the free radicals that can also cause cancer. However, there is more to broccoli than just that. Broccoli contains the highest concentration of sulforaphane of all the cruciferous vegetables that include Brussels sprouts, cabbage, cauliflower, rocket and turnip, amongst many others. When you chew broccoli, the glucosinolate glucoraphan is converted to sulforaphane, not by the enzymes in your saliva, but by the actual physical damage done to the plant by the act of chewing. It could likely also be generated by hitting it with a hammer! It is glucosinolates that provide the slightly bitter taste many people experience when they eat vegetables such as brussels sprouts and broccoli, and that likely renders them somewhat unattractive to children! Sulforaphane is an isothiocyanate containing the NCS functional group, and is actually bound loosely to the sugar as sulforaphane glucosinolate. It is the loose binding that allows it be released on chewing. Broccoli sprouts are its richest source, and it is a strong antioxidant which is why it is so effective in reducing the possibility of certain cancers. When fighting cancers, your body produces phase-II enzymes, and since sulforaphane induces these enzymes, it stops the carcinogens before they can damage your DNA. This is achieved through the enhancement of the transcription of the proteins that suppress the tumors. In layman’s terms, it is the generation of tumor suppressant proteins from DNA that kills off the tumors before they can destroy the DNA. There is even more however. Indoles have already been mentioned, and those in question are predominantly indole-3-carbinol (I3C) and 3,3-diindolylmethane (DIM). The latter is generated from the digestion of the former and possesses very potent anti-cancer properties. However, this indole can affect your health in ways other than just as an anti-cancer agent. It can modulate the immune system in a way that renders it suitable for the treatment of a number of viral infections, and is also believed to be a possible answer to the problem of bacteria that have become resistant to antibiotics. It appears to operate synergistically with Interferon-Gamma, a cytokine that helps to prevent viruses from replicating within the cells of the body, to strengthen the MHC-I Complex, a part of the human genome that supports the immune response to viral attacks. To put it plainly, broccoli can aid your resistance not only to certain cancers, but also to attack by viruses and some bacteria. It is not only cancers of the cervix and breast that broccoli can help to prevent, but also of the lung, prostate, larynx and bladder. I3C also helps to support the function of your liver in detoxifying your blood as well as supporting the cellular reproduction without which your body could not maintain itself after damage. Broccoli is therefore an important vegetable to men as well as to women, not only for its anti-cancer properties, but also as a general antioxidant and consequent free radical scavenging properties. Its high fiber content is equally split between soluble and insoluble vegetable fiber, and so meets your dietary needs of both types. Cruciferous vegetables such as broccoli have been singled out by health organizations the world over as essential to your diet, and you should eat them regularly. Once daily would be good, but more is recommended if possible. As stated at the start, strong tasting vegetables containing glucosinolates might not be attractive to children and younger people, but their phytochemical content (the foresaid indoles and isothiocyanates) render them very potent antioxidants and anti-cancer foods. Taken in relation to other foods, an ounce of broccoli contains as much calcium as a glass of milk, more vitamin C than a similar weight of orange, and a medium floret has more fiber than one slice of bran bread. It is rich in vitamin A and of course there are the other antioxidants and anti-cancer phytochemicals already detailed. There are many ways of cooking broccoli to maintain its nutritional content, but if you do not like broccoli, then there are supplements available. You can purchase pure broccoli extract or an extract from a mixture of cruciferous vegetables. The choice is yours, but of one thing there can be no doubt. Broccoli is the king of green vegetables, and the nutrients it contains are not available in any other vegetable in such a concentrated and easy to assimilate form.
Your mom was right: it's not just 'eat your veg', but 'eat your broccoli'. No nutritional advice could be better than that. “Pass the broccoli please mom!”
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1704) Give Your Health A Boost With Silica Hydride A Powerful Antioxidant
Date:
January 18, 2008 05:25 PM
Hydride ions are strong proton acceptors and hence fatal to free radicals. Silica hydride is consequently a powerful antioxidant that can be used to protect your body against the ravaging effects of these free radicals that destroy the cells of your body, and due to its other unique properties this is a molecule that could be a very useful participant in the various redox reactions that occur naturally within our bodies every microsecond of every day of our lives. A free radical is a positively charged molecule that is deficient in an electron. Whereas stable compounds consist of electron pairs, a free radical consists of electron pairs and one unpaired electron. Although such a compound is not stable, it does not immediately disintegrate but grabs the nearest electron it can find. This would normally be an electron in the nearest body cell to it, whether it is a blood cell, a cell in an artery wall or a skin cell. The result is that the cell that loses the electron is disrupted. Free radicals are formed in the body through its normal biochemistry, and also promoted by pollutants such as cigarette smoke, pesticides and traffic fumes. Excessive exposure to the ultraviolet radiation of sunlight or sunbeds also creates free radicals, as does excessive exercise, believe it or not. As stated earlier, these chemicals have only one purpose in your body: to grab an electron from wherever they can, and in doing so they destroy the cells that make up your body tissue. This can lead to premature aging, heart disease and many other problems with your health. Antioxidants such as vitamins C and E are important parts of your diet, and silica hydride is an other supplement which has been relatively recently discovered to have antioxidant properties. A component of glacial streams, this substance is generally in colloidal form, or in the form of small particles maintained in suspension by the interaction of positive and negative charges on the surface of the tiny particles of which it consists. The interface between the silica and water can be saturated with reduced hydrogen to form a surface that is overall negatively charged and can hence neutralize free radicals that are seeking the free electrons available from the negative charge. This is otherwise described as a reducing or anti-oxidant effect. All anti-oxidants play their part in neutralizing the properties of free radicals that result in the destruction of body cells. This leads to premature aging of your skin, if a skin cell is affected, if it is a cell in your artery wall, then the artery will become damaged, and if a blood cell then you can suffer from any one of a number of abnormal blood conditions. The stealing of an electron from one molecule by another is scientifically termed 'oxidation', and the substances that prevent this from occurring are called antioxidants, or reducing agents. An antioxidant will destroy free radicals by providing the extra electron, or chemically, a negatively charged hydrogen ion. This occurs practically instantaneously, in microseconds in fact, as soon as the free radical is formed, so you need a good supply of antioxidants in your body at all times. Free radicals do not roam your bloodstream looking for likely candidate cells to destroy – they do it right away with the nearest available, so antioxidants must be present at the time that the free radicals are created. Other beneficial effects of such antioxidants are an increase in the potential for the mitochondria to generate energy within your cells, an increase in the hydration of body cells and a decrease in lactic acid build–up that occurs as the result of exercise. The negative charges of silica hydride atoms are very strong antioxidants and can dramatically increase the energy production of mitochondria. It has been shown to do so by up to six times in Chinese hamsters. There is more on this claim for such a significant effect on your energy production later. In addition to its action as an antioxidant, silica hydride is an electron donor to other antioxidants that have been neutralized by reaction with a free radical. When antioxidants do their work they are not destroyed, but neutralized. They act by giving an electron to the free radical, and are then one electron deficient themselves. This could virtually turn them into free radicals also were it not for the other electron donors available. Silica hydride is one of these. Thus, Coenzyme Q10, another very powerful antioxidant, can have is potency regenerated by silica hydride. If you take a silica hydride supplement, you are not only taking an effective antioxidant, but also a substance that can recharge the batteries of other powerful antioxidants. Another side effect of this substance is that the reacted hydrogen atoms can also be used in the body to maintain a slightly alkaline pH which is an additional health benefit. pH is a measure of the acidity and alkalinity of the body fluids, and should be maintained slightly alkaline, other than in the stomach where the digestive juices are strongly acidic. Silica hydride is not essential to the body, so you cannot suffer from a deficiency of it. It is not known to be contained in any foodstuff or water source, and appears to be available only as a supplement. Consequently no optimum dosage has been determined, though the supplements available contain from 200 to 250 mg per capsule. Likewise, side effects from it are unknown since there have been few scientific studies carried out on it. It has, however, been described as the ‘perfect antioxidant’. Some of the claims made for the substance include reducing lactic acid concentration during exercise. Lactic acid production during exercise causes tiredness and cramps, and silica hydride is said to increase the body’s production of adenosine triphosphate (ATP) a substance essential for the production of energy in your body. This is through the reduction of nicotinamide adenine dinucleotide (NAD) to the reduced form NADH as a part of glycolysis and the citric acid cycle. Glycolysis is the metabolism of glucose to energy by the mitochondria. If the claim that silica hydride effects this reduction of NAD to NADH six or seven times stronger than normal were true, then it would indeed be a significant energy booster invaluable to most athletes.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1697) How to Manage Migraines Naturally: Magnesium - Feverfew - Butterbur - Ginger
Date:
December 21, 2007 10:41 AM
Before you can understand how to manage migraines naturally, it is necessary to understand exactly what they are and how certain treatments could work. It is not generally known that the word ‘migraine’ means ‘half the head’ because it frequently hurts only on the right or the left of the head of sufferer. Some people with migraines do feel pain on both sides at once, although this is not generally the case. A migraine occurs in stages which are activated by fluctuations in the hormone content of the blood. The ‘aura’, when you see spots and flashing lights in front of your eyes, is the first stage of a migraine attack, and during this time the blood vessels in your neck and head are contracting. You could also find it difficult to concentrate and your fingers could feel cold. At this point they do not have the headache that starts when the blood vessels begin to dilate. Rather than the contracted blood vessels slowly returning to normal, your hormones have an excessively strong reaction, and cause them to dilate rapidly and become much wider than they should be leading to a severe headache due to pressure on the nerves. Different hormones can be involves with each attack, and the range of effective natural treatments reflect this fact. During this period, your brain could swell slightly, your muscles can tense up and other things can happen to the chemical and hormonal balance of your body. That is why some herbal treatments work for some but not for others, and different people find different treatments effective for them. What works for you might not work for somebody else if their migraine has a different cause. Basically, though, migraines occur in two phases, one being associated with an excess of hormones and the other with a shortage. It is not easy to live with a migraine since it can be completely debilitating. Some just have a severe headache, while others are affected for days at a time. The headache can become before and after the onset of the shimmering lights and other optical effects that are generated by the brain. It would certainly be useful if those prone to migraines had one or more of the possible natural remedies to hand since there is rarely time to seek to seek professional medical help once the migraine begins, and through the use of natural remedies a potentially bad attack could be nipped in the bud, and at least its effect on you reduced. MAGNESIUM Magnesium is common in green leafy vegetables such as spinach and cabbage, whole grains, nuts and seeds. It is an essential mineral for human biochemistry, and is also needed with calcium for healthy bone development and maintenance. Magnesium is a muscle relaxant, and relaxes the muscles of the blood vessels helping them to relax their dilatancy that cause the migraine pain. It is also useful to help the immune function, reduces blood pressure (by the same blood vessel relaxing mechanism) and also the rhythm of your heart. Magnesium therefore provides you with many health benefits, and though the western diet is not generally deficient in magnesium, some areas can be and a magnesium-containing supplement will not do you harm. However, particularly high dose of magnesium can lead to nausea, diarrhea, low blood pressure and many other unpleasant side effects, so do not take more than the RDA (recommended daily allowance) in your supplement. Many studies have confirmed its effectiveness in reducing the symptoms of migraine, but not all studies have been successful. However, the condition is so debilitating to so many people, that it should be tried although not in excess. Make sure, however, that your doctor is informed since it could interfere with other medication you are taking for your migraine. Riboflavin, vitamin B-2, is also believed to useful in reducing the duration and frequency of migraine attacks, working in much the same way as magnesium. It is known that there are many cases of people who suffer from vitamin B-2 deficiency also suffering from migraines, and a riboflavin supplement is also worth trying if you are a consistent victim of this condition. FEVERFEW Feverfew is the best known of the herbal remedies for migraine, and has been used for centuries in the treatment of fevers, headache, migraine and other painful conditions such as arthritis. The active ingredient is parthenolide, an anti-inflammatory that is also an anti-hyperalgesic, and that would explain its effect on reducing the pain. It also blocks lipolysaccharide-induced osteolysis by suppressing the activity of a eukaryotic transcription factor protein known as NF-kappaB that can cause a number of immune response problems, including inflammatory conditions such as arthritis, hence its use to relieve that condition. Its effect on migraines could be explained by this activity in repressing the inflammatory response to certain stimuli that could be brought about by hormonal activity. Because it must be taken for a few weeks before the actual problem arises in order to be effective against it, feverfew is not effective to treat an existing attack, but to prevent future attacks. Double blind studies have proved its effectiveness in many tests, but not in all. However, if you take feverfew as a regular supplement in you diet, you might never have to try magnesium or vitamin B-2 supplements. Some people swear by the leaves of feverfew, eating one per day which is easy way to take it. It is important, however, that you do so regularly, since it can take for up to 6 – 8 weeks for you to notice a reduction in your attacks. Don’t give up after 5 or 6 weeks, but continue, since the results will be well worth it. If you stop for a week or two you will have to start all over again. You might get a sore mouth and perhaps mouth ulcers to start with, but these will eventually go once your body is used to it. You are probably best not to take if you are pregnant since it could cause you to abort. Otherwise, however, it has been shown to be effective in many severe cases. Feverfew is bitter, and can be used as a tea with other herbs, such as rosemary, lavender and sage. If you are taking warfarin, aspirin or other blood-thinning drugs, see your doctor first, and the same is true of NSAIDs (non-steroidal anti-inflammatory drugs). If you are taking these for arthritis, the feverfew itself might be more effective! If you are taking feverfew as a supplement using commercially available dried leaf then the recommended dosage is around 125mg of the dried leaf. It should contain at least 0.2% of parthenolide (0.25mg/daily), although other studies have indicated that a total of 0.7 mg parthenolide a day should be taken (100mg at 0.7%). Parthenolide is unstable so don’t take it after its sell by or best by date. BUTTERBUR Butterbur is also useful in the treatment of migraines. The active ingredient here is petasin, a sesquiterpene ester that also has anti-inflammatory properties, all though it works in a different manner to feverfew. Here, it inhibits the activities of leukotriene generation in neutrophils and eosinophils, which indicates that it also possesses anti-allergenic properties that could help asthmatics that also suffer from migraines. It does not prevent the release of histamine, but does appear to reduce smooth muscle spasm. You should never take the raw herb, only the extract, because it contains alkaloids that can harm you. The butterbur extract, however, is a perfectly safe supplement and found effective by many people in the treatment of migraine. GINGER If your migraine is at the front of the head, then you should try ginger. Unlike feverfew, ginger works on a migraine as it is occurring, and improvement can be achieved for a bad migraine within half an hour. In fact if, like many people, you can feel a migraine coming on, half a teaspoon of freshly ground ginger can stop the pain before it starts. Many herbal treatments for migraine include a combination of some of the above remedies, and many people swear by them. However, migraine treatment is very personal, and you should use what works best for you. If you are also taking other medical treatments however, please make sure that you refer to your physician before using any others, and that includes herbal remedies or supplements.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1678) Support A Healthy Digestive System With Discount Vitamins
Date:
November 21, 2007 10:31 AM
Discount vitamins can help to support a healthy digestive system, but to explain how they do you first need to know how the system of pipes, tubes and chemical plants that make up the digestive system basically works. The digestive system is a system of tubes through which your food is passed during the various stages of digestion, and also organs that produce the chemicals needed to break down your food into the nutrients needed by the body. The digestive system begins with the mouth, where the teeth cut and grind the food, and mix it with saliva containing the enzyme amylase that begins the digestive process by converting starch into maltose and dextrin, which are later converted to glucose. Amylase cannot work in the acidity of the stomach, which is why you should chew starchy foods such as bread and potatoes before it is swallowed and passed down the esophagus to the stomach. The stomach is a natural food processor, containing concentrated hydrochloric acid that breaks the food down into smaller molecules. Once the food has been mixed and processed it passes into the small intestine where the real digestion begins. The liver and pancreas manufacture digestive juices and pass them into the intestine as the food is expelled from the stomach. These juices are mixed with the food, break it downs chemically into nutrients which are then absorbed through the walls of the intestine. The waste is passed into the colon, from which they are later expelled. While in the stomach, its glands produce not only the stomach acid but also enzymes that break up proteins into smaller compounds including amino acids. The liver produces a number of digestive juices, including bile that dissolves fats and renders them water soluble to be digested by enzymes from the pancreas. The liver also produces enzymes that further breaks down the food in smaller molecules. The whole process is controlled by the digestive hormones that are generated by the stomach and small intestine, namely secretin, gastrin and CCK (cholecystokinin). These control the release of the various digestive juices and chemicals into the digestive system, and once the food has been broken down the nutrients are absorbed into the bloodstream and transported to the cells of the body where they are needed. So, starting again from the top, how do discount vitamins and minerals help to support a healthy digestive system? First, we start with the teeth. It is essential for the proper use of food that it is shredded and ground properly before being passed to the body, and that the starches are broken down by the saliva enzyme amylase. The structure of your teeth is dependant on vitamin C and D, and the minerals calcium, phosphorus and magnesium. A deficiency in any of these would result in poor weak teeth, and your food would not be prepared properly for your stomach. Vitamin B1 keeps your nerves in good working order, without which your appetite could not be regulated. Vitamin B3, or niacin, keeps the digestive tract in a healthy state and functioning properly. Vitamin B9, or folate (folic acid) carries out a similar task, and the B complex vitamins in general, then, keep the digestion process working smoothly and the peristaltic motion that moves the food along, also in good working order. Manganese and chromium are essential minerals to the digestive system, without which enzyme activity would be limited and without chromium your appetite could not be controlled. Apart from that there is a lot that can go wrong with the digestive system and a good vitamin B complex or Vitamin B1 and B3 supplement, will help to maintain the proper functioning of the system. These vitamins will encourage proper control of the intestinal muscle function, and vitamins C and E will help deal with any inflammation in the bowel, or undue immune system activity. Acidophilus will also help to maintain a good population of healthy bacteria that are essential components of your digestive system. A probiotic supplement taken as instructed should achieve this. A little considered function of the digestive system, perhaps because it actually takes place in the liver rather than the alimentary canal itself, is the disposal from the body of toxin absorbed by the small intestine. This is the chemical transformation of certain molecules into a form whereby they can be rendered water soluble and expelled in the urine. Substances such as drugs, alcohol, paint fumes and so on are formed into other chemicals that might be even more toxic than the originals for a short time, and since oxidation is used in many of these reactions, free radicals might be formed that can harm the body. This danger, which is indirectly caused by the digestion of these substances, can be relieved by maintaining a sufficient intake of antioxidants in the form of Vitamins A, C and E to neutralize them. Some liver disease is caused in this way by insufficient vitamin nutrition, and a good discount vitamin supplement can help to prevent it by destroying the free radicals as they are formed. This detoxification process then proceeds to a phase where the biochemically converted molecules are rendered into the water soluble form so that they can dissolve in the blood and be extracted by the kidneys into the urine. For this, a good supply of the tripeptide glutathione, glycuronic acid and some amino acids is needed. A supplement of these should also help the detoxification process. Other supplements that can help the digestive system are natural enzymes. These work whether taken on an empty stomach or with food. On an empty stomach, at least two hours after a meal, they will immediately go to work in your blood and improve its condition. Taken with a meal they will help digestion the fats and reduce food waste by improving absorption. There are many ways in which you can help to maintain a healthy digestive system by the use of discount vitamins, although any problem with your digestive system should be referred to your physician since there are many serious conditions that need expert medical treatment. Vitamins, enzymes, probiotics and other supplements, however, can help to prevent many of these from occurring.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1637) Green Coffee For Protection Against Oxidative Stress
Date:
November 17, 2007 11:46 AM
It is recorded that coffee drinking originated in Ethiopia in North East Africa, from where Arab traders introduced the plant to the Middle East. From there it moved to Turkey in the 15th century, where it was highly prized as a daily beverage due its invigorating properties. It is also believed that the infamous Captain John Smith introduced the plant to Virginia. The Brazilian coffee trade was due largely to the introduction of the bean to that country by the French in 1727, and the Boston Tea Party of 1773 rendered it the only non-alcoholic drink worth consuming by the patriots of 18th century America. Now over 50% of Americans drink coffee daily, although this seems a somewhat conservative estimate, and the tea houses of England have largely been replaced by coffee shops and the ubiquitous Starbucks. So much for the history of a beverage that has been prized for its stimulant properties, but recent research has established that not only is coffee a stimulating drink, but that it is a strong antioxidant due to its polyphenol content. However, not all forms of coffee have this property, only the green coffee bean before it has been roasted. Polyphenols are very powerful antioxidants that scavenge the free radicals that destroy body cells, and not only accelerate aging but also threaten the health of your cardiovascular system and the health of other major organs. Free radicals are compounds with a spare electron. Normally the electrons in all stable molecules come in pairs, and any free electron without a partner is like a lovelorn bachelor. It will seek a mate, and take it from wherever it can find one. Usually it secures its partner by stealing an electron from one of our body cells. This can totally destroy the cell, as it might anybody who has its partner stolen, and cell destruction is not a good thing. It is the destruction of body cells that promotes the appearance that aging brings: the wrinkles and the loss of energy that is generated by healthy cellular activity. Antioxidants destroy these free radicals, and come in a number of different guises. Vitamins A, C and E are all powerful antioxidants, as are many of the compounds that are essential to our biochemistry such as beta carotene and polyphenols. These polyphenols are found in practically all plants to a greater or lesser degree, and another rich source is grapes, and those found in green coffee beans are what are known as hydroxycinnamic acids the most abundant of which is caffeic acid. Another is chlorogenic acid, and together they form a very potent team in preventing the oxidation by free radicals of LDL (low density lipoprotein). Low density lipoproteins are those that carry cholesterol from the liver to areas of the body that need first aid due to damage, such the arterial walls. However, this can be attacked by free radicals and oxidized which results in the deposition of excess cholesterol that can build up till it eventually constricts, and sometimes completely blocks, the major cardiac arteries. This is a serious condition known as atherosclerosis that can eventually lead to cardiac disease and arrest or to strokes if the artery is in the brain. Not only do chlorogenic and caffeic acid help to prevent this from occurring, but they also help to prevent the cellular degeneration caused by the free radicals. They must be extracted from the green coffee bean because roasting or heating in any way, including brewing, destroys them. In fact, brewed coffee contains some potentially harmful substances called diterpenes that some believe can increase your chances of coronary disease by up to fifth if you drink coffee regularly over your lifetime. It is also believed that green coffee extract can reduce the risk of diabetes due to its effect on your blood glucose levels. Evidence is coming to light that some polyphenols, including chlorogenic acid, might have inhibiting properties on the activity of glucose-6-phosphate, otherwise known as Robison Ester, which is involved in the metabolism of blood glucose and which is affected by diabetes which reduces its concentration. Chlorogenic acid is though to be able to redress this imbalance and not only reduce blood glucose levels, but increase the glycogen stored in the liver as an emergency energy source for the body. Green coffee bean extract also possesses other beneficial properties, not the least of which is its effect in increasing the metabolism of fats in relation to carbohydrates. This assists in weight loss and also increases stamina. The decrease in the risk of diabetes of up to 50% in men, and slightly less in women, could be due to a combination of the regulation of glucose-6-phosphate and the regulation of blood glucose levels and glucose and weight management in general. The vast majority of diabetes patients are overweight. In animal studies, the presence of chlorogenic acid appears to reduce the hyperglycemic peak that arises through the action of glucagon, a hormone used to counter hypoglycemia. The fact that chlorogenic acid reduced this sugar peak indicates its potential use in reducing abnormally high blood glucose levels. Another effect of this was an increase in the animal’s glycogen level and in the level of glucose-6-phosphate in the liver. This indicates a reduction in glycogenolysis, by which glycogen is ultimately converted to glucose-6-phosphate and glucose, thus increasing the blood glucose levels and also of gluconeogenesis which is the production of glucose from carbohydrates and some glucogenic amino acids. In other words, green coffee bean extract can help to regulate blood glucose levels by preventing the liver from producing glucose from glycogen and carbohydrates. However, the biochemistry apart, it must be stressed that these benefits are not obtained by drinking coffee, and it has to be repeated that the active agents in providing them are destroyed by the roasting and brewing processes. It is only the green coffee beans that can be used for protection of oxidative stress of human body cells and the gradual degradation into premature aging and many other related conditions.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1635) Milk Thistle May Help With Cirrhosis, Gallstones, and Hepatitis Liver Problems
Date:
November 14, 2007 12:34 PM
Milk thistle, botanically Silybum Adans, is a member of the daisy family that is native to the Mediterranean, the Middle East and North Africa but has also been introduced to California and parts of the eastern side of the USA, and can help with problems such as cirrhosis, gallstones and hepatitis. Although it has been recorded as being used in medieval times as a tonic for the liver, it is only relatively recently that its chemical components have been investigated. Analysis indicated the presence of hitherto unknown flavonoids which were given the name of silymarin. In general, flavonoids are strong antioxidants found in many fruits and vegetables that eat up the free radicals that cause so much damage to our bodies. Free radicals are very unstable molecules that are generated through pollution, such as smoking, car fumes, perticides etc, and that destroy body cells accelerating aging. They also oxidise the low density lipids (LDL) that carry water-insoluble cholesterol through the blood to the arteries where it is needed to repair damage, resulting in excess deposition and the atherosclerosis that can cause strokes and heart disease. Antioxidants mop these up like a sponge, and are some of the healthiest types of molecules that we can consume. The silymarin group of flavonoids are particularly attracted to the liver where they act as antihepatoxic agents that prevent the liver from becoming poisoned. But why should the liver be poisoned I can hear you ask, and what are the poisons involved? Can we avoid them? It is a very relevant question, and one that will make you wonder, every time you leave your home, especially if you live in a big city or an industrialized area. Smoking cigarettes, working with volatile organic compounds that you can breathe in, such as paint and printing ink solvents, the exhaust fumes of cars and diesel engines, factory chimneys belching out tons of smoke, analgesics such as paracetamol, pesticides on your fruit and vegetables that you have failed to wash off, alcohol, etc, etc, etc… All of these have to be removed from your body or you will die, awash with all these poisons that you have ingested, some deliberately and some not. The organ that does this is your liver: the powerhouse chemical plant of your body that carries out millions of biochemical reactions every day. Your liver converts all of these poisons into molecules that can be flushed away through your body naturally. However it places great stresses upon it, and even your liver needs a rest sometimes, or even just a little rejuvenating tonic would keep it happy. Milk thistle has been used for just that purpose, especially when the liver has been toxified with excess alcohol, pesticide poisoning or even hepatitis. The silymarin initially coats the cells of the liver by binding to the cell membranes of the cell walls, so that the toxins are hindered from entering the cells. Its antioxidant properties then neutralise any free radicals present that are causing the damage to the liver cells. It also helps to stimulate the production of proteins to help the healing process, and reduces the fibrosis that is the development of fibrous masses outside the liver cells caused by damaged cells excreting materials such as collagens outside the cells into the general body of the liver. Finally, milk thistle helps to prevent the activity of the immune system in causing inflammation of the damaged cells. Silymarin acts very specifically on the liver, and is often used by physicians in the treatment of such liver conditions as jaundice, hepatitis, liver cancer and cirrhosis. In addition to its own effects it appears that it stimulates the production of glutathione that is also a very powerful natural tripeptide antioxidant produced by the body when it is under oxidative stress. Its effect on cancer and some diseases is not curative, but to allow the liver to continue to detoxify the body when otherwise it might fail and lead to toxicity problems from which the patient might not be able to recover. Due to the remarkable regenerative powers of the liver, milk thistle is able to stimulate it into repairing its damage and grow fresh cells to replace the damaged ones. This is the reason for its effectiveness in otherwise very serious degenerative diseases. It is often prescribed by doctors for patients who are taking a number of different medications. Which help the liver to metabolize these medications, since without it, it might struggle to provide the true efficacy of the prescribed drugs. So far we have been concentrating on the liver, but milk thistle has other properties not connected directly with the hepatic function. It can help to promote the production of bile in the gall bladder and so give the digestive system a boost when needed, where it also acts as a mild laxative. However, it can also help patients suffering from both lose stools and constipation due its effect. It can also help to relieve gallstones, though medical tests are generally carried out first to ensure that they are not too large for the milk thistle to handle. It is also an anti-inflammatory, and is useful in the treatment of acne and other inflammatory responses, and also for inflammations in the gall bladder, kidney and bladder. There are few serious side effects, although, as milk thistle rids the body of toxins, these toxins can cause problems such as diarrhea, headaches and abdominal pain. Keep in mind that you are releasing poisons from the liver into your system so that they can be expelled by the usual means, and they will put up a fight along the way. However, the milk thistle will usually win in the end. There currently appear to be no long term issues with taking milk thistle as a supplement over a long period, and it is good way to maintain a healthy liver. Keep in mind that the liver is the body’s chemical plant, where most of the biochemical reactions of life take place, and without we cannot survive. It makes sense, therefore, to look after your liver, and milk thistle is one way of doing that; some would say the best way.
So remember that, although milk thistle may help with cirrhosis, gallstones and hepatitis liver problems, you should be prepared for a short struggle before it wins the day. Always consult your family physician for a clear diagnosis before self prescribing herbs as treatment. Your physician can advise you as the correct course of action to take once diagnosed with a liver blood test first. But, to boost overall health and wellness milk thistle is a great herbal supplement to take on a daily basis.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1631) Omega-3 Relieves Depression in Some Individuals
Date:
November 02, 2007 03:27 PM
Omega-3 oils contain fatty acids that are known as essential fatty acids because they cannot be manufactured in your body but have to be taken in your diet. They provide many benefits to your body, and are also believed to relieve depression in some individuals. First, however, an overview of the more conventional benefits of omega-3 oils. Obtainable in your diet from oily fish such as mackerel, herring, salmon and the like, omega-3 fatty acids play an important part in your normal growth and development, and are also crucial to normal brain function. They can reduce inflammation and protect you from heart disease and some cancers. Studies have shown the fatty acids to be particularly concentrated in the brain and to be important for cognitive processes and memory. The effects of omega 3 fish oils on the brain are well documented, and they are known to be effective treatments in some cases of bipolar and schizophrenia. It is believed that they could also be used as a treatment in other disorders such as attention deficit disorder and dyslexia, but there is as yet no evidence that this is the case. Omega-3 fatty acids reduce the so-called ‘bad’ low density lipoprotein (LDL) cholesterol levels and increase the high density lipoproteins (HDL) that take the cholesterol back to the liver for destruction. The end result is a reduction in the cholesterol content of the blood that can be deposited on the artery walls and promote atherosclerosis. Diets high in omega-3 fatty acids appear to lower blood pressure in those suffering from hypertension, and so reduce their chances of heart attacks and strokes. Omega 3 oils are also natural inflammatories, and help prevent conditions involving inflammation such as arthritis, asthma and menstrual cramps. They appear to help the immune system to fight these conditions and reduce the inflammation and its causes. They are also important in the formation of prostaglandins that are responsible for the regulation of important functions such as blood pressure, blood clotting and immune response. They are hormone-like substances and also control the synthesis in the body of other hormones. If the balance of fatty acids in the diet is not right, then the subsequent imbalance in prostaglandin and hormone production can lead to disease. It is in its effect on depression and mood, however, that has surprised many in the medical, profession. Ethyl-eicosapentaenoate, known as ethyl EPA, is a constituent of omega-3 fish oil and many studies have demonstrated that this substance helps cases of depression and related disorders. However, are people justified in turning to ethyl EPA to help them be cured of this condition? In one study involving 20 people, six out of ten people given the supplement displayed significantly reduced symptoms of depression after four weeks. The effects were noticed as early as two weeks and many of the depression symptoms, such as worthlessness and insomnia, had improved after three weeks. This conformed with the results of many other studies that have been carried out world wide. In Scotland, a number of patients were studied who had failed to respond to traditional antidepressant drugs. Of the seventy patients involved in the trial, all of the patients who were treated with EPA displayed significant improvements in all the symptoms of their depression after four weeks whereas those with the placebo showed no improvement. Of the two main components of omega-3 fish oil, EPA and docosahexaenoic acid (DHA), only the EPA has this property, and the EPA works best alone when the DHA has been extracted. Studies and tests have indicated that the DHA appears to be important for the brain’s structure, but the EPA for its function, hence the reason for the ineffectiveness of the former in relieving depression which is a function of the brain rather connected to its structure. In fact, depressed people have been found to be deficient in EPA in comparison to those not suffering from the condition. The original idea for this originated with the late Dr. Horribin who was pioneer in researching the effects of lipids on the biochemistry of the brain as far back as the 1970s. Since then the world-wide research has confirmed his theory. However, the reason why this theory works in practice is not yet understood. It has been established that a diet rich in trans fats can unfavorably affect the hormones in the brain that stabilize mood, possibly due to the fats slowing down the system of messaging within the brain. This kind of effect can cause depression. This is likely due to the slowing down of the messages passing between the synapses. Brain cells communicate by means of chemicals that cross the synapses, or small gaps between the individual cells. They are not directly connected like normal electrical circuits. It has been theorized that the EPA speeds up the passage of these messages between neurotransmitters and neuroreceptors. Other theories have also been promoted, such as that the EPA has properties of its own that cure depression by another route altogether. A possible clue could be in the findings of one study on a man aged 21 years old whose brain was scanned before and after EPA treatment. The result showed in increase in the mass of brain cells after the treatment. This was contrary to the belief that brain cells could neither be generated nor grown once a person reaches maturity. An individual suffering depression who would like to treat themselves with EPA would have to buy a lot of oily fish since high doses are needed for this level of therapy. However, it is found in high concentrations in a few supplements available on the market, and when choosing you must use the highest grade of EPA you can get, with as low a DHA content as you can find. There is little doubt now; however, that the EPA content of omega-3 relieves depression in some individuals, although more work is needed to prove without doubt that it is effective with all forms of depression.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1613) Natural Vitamin and Herbal Alternatives For Joint Health
Date:
October 18, 2007 03:58 PM
Joint tissue breaks down and arthritis sets in for a number of reasons, and there are several natural alternatives for joint health that can be use to prevent this and to treat affected joints. Thyroid problems can slow down the production of adrenal hormones that are responsible for the production of cortisone and cosrtisol. These are anti-inflammatories, that when unavailable or in low supply can result in joint inflammation. If you suffer joint pain in the mornings that tends to improve as the day goes on, then it is likely that is the cause since adrenal activity can improve as the day progresses. One of the main reasons for joint tissue breakdown is osteoarthritis whereby the cartilage wears down until it fails to provide the necessary protection against impact between the bones in a joint, or against the friction generated when two bones rub together. Injuries to joints can have the same effect, whereby an injury to a hip or knee can appear to clear up and then later the cartilage wears out sooner than expected. This can take several months or many years, depending on the severity and nature of the injury concerned. Continual wear and tear can also cause joint tissue to break down. Athletes and other sportspersons often suffer twenty years or more after retirement from their sport due to the gradual wearing down of cartilage while they were active. Once they stop, this continues to a lesser extent until the cartilage is eventually worn away sufficiently for it to stop protecting the joint. Problems with the auto-immune system can lead to rheumatoid arthritis and inflammation of the joints. This weakens them and can eventually completely destroy the tissue. In such cases the tissues in the joint tend to swell and become extremely painful. Gout can also damage joints, especially in the big toe. This is caused through a built up of needle sharp uric acid crystals. Another cause is a deficiency in sodium and potassium in the diet that are needed to help maintain calcium in solution. When these metals are in deficiency due, for example, to an adrenal problem or some other reason, calcium can deposit right in the joints, causing undue pain. Calcium and vitamin D deficiencies are commonly associated with arthritis sufferers, and protein deficiencies are also believed to be a contributing factor of rheumatoid arthritis, and it is also true that degenerative arthritis can accompany rheumatoid arthritis. This occurs in almost 40% of cases, and diet and nutrition are now being recognized as a major cause of both types. Deficiencies in folic acid or its natural form of folate, vitamin E, zinc and selenium have all been associated with degeneration of joint tissue, so it makes sense that a supplement of these substances can help to avoid these conditions. Standard medical treatment, however, is for the relief of pain and reduction of inflammation through the prescribing of non-steroidal anti-inflammatory drugs (NSAIDs). Typical NSAIDs are aspirin, ibuprofen and naproxen. Although it relieves pain, paracetamol is not an anti-iflammatory. An alternative to blocking the inflammatory reponse is to help to regenerate the damaged joint tissue. However, reducing the inflammatory response to tissue damage does not address the underlying problem, but masks it. Not only that, but there are side effects associated with the use of NSAIDs. Excessive doses can create serious gastrointestinal problems, such as bleeding, ulcer perforation and even death is possible in severe cases. Anti-inflammatories cause gastric problems in up to 20% of cases The newer Cox-2 inhibitors act on the enzyme that causes the inflammation within the joint, and while these can be very effective, they are still masking the underlying problem. Incidentally, the Cox-2 inhibitors should not be used with NSAIDs, and both increase the possibility of a myocardial infarction or heart attack. Also, if you are taking aspirin to reduce the risk of heart problems, you should be careful not to use other NSAIDs since they can interfere with the effects of the aspirin. More effective in the long run is to treat the conditions with substances that deal with the cause of the problem. Vitamin C, for example, improves the lubrication effect of the synovial fluid in the joints, and vitamin E is a strong antioxidant that can help to repair damaged tissue and improve the circulation within the joints. Joints have very low blood circulation levels, which is a problem when trying to direct drugs to the joint tissues. Vitamin C is also good for improving the integrity of connective tissue. Zinc, manganese and copper are also instrumental in developing strong connective tissue and helping to repair the damage done to the joints. Horsetail is a commonly used herbal remedy that can be taken as a tea, tincture or in capsules. It is the richest natural herbal source of silicon, which is used by the body to form connective tissue and collagen. Damaged connective tissue is rapidly repaired by horsetail, and its strength and elasticity significantly improved. It is commonly used in the treatment of arthritis and osteoporosis. Cat’s Claw is used for its beneficial effect on the immune system, and frequently used successfully to treat osteoarthritis and rheumatoid arthritis. However, this treatment is used more to help reduce the inflammatory effects of the condition than to effect a long lasting cure. Gotu Kola, also called Indian pennywort, is traditionally used for treating arthritis. The fresh leaves are effective in reducing the inflammation and pain, and help to improve the quality of life of arthritis sufferers. In Australia, it is referred to as ‘the arthritis herb’ and two leaves a day are said to be effective. Another popular remedy is MSM (methylsulfonylmethane), although it is claimed to provide pain relief rather than a cure. Amino acids also seem to help, and L-cysteine helps promote collagen and connective tissue. It appears to work best when taken in combination with vitamin E and selenium that are powerful antioxidants. L-arginine has a similar effect in the reconstruction of joint tissue, again helping to repair damaged connective tissues. There are therefore two approaches to treating both rheumatoid and osteoarthritis, one providing pain relief and reducing inflammation, and the other repairing the damage done to the joint tissues. Vitamins, minerals, trace minerals and herbal remedies are used in both, though it is better to use a combination that provides pain relief and also helps to regenerate strong connective tissues in the joints. When using combinations of remedies it is important that possible interactions are understood, and you should always seek the advice of your physician when using non-prescription remedies of any kind.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1597) The Growing Organic Market Place
Date:
June 26, 2007 01:51 PM
It probably doesn’t come as much of a shock that the market for organic produce is growing—estimated by various sources at about 20 percent a year. What may be surprising is that the organic food market, which generated about $13.8 billion last year, represents only about 2.5 percent of the total U.S. food consumption. While those of us involved in the natural products industry or natural healthcare take for granted the advantages of organic products over “traditional” ones, there is a pressing need to mobilize resources in order to meet the consumer demand for pesticide-free foods. Currently, only 0.2 percent of the U.S. farmland is organic. The other 99.8 percent produces food utilizing the high-production, low-nutrient and flavor lacking industrial chemical methods we grew up with—the same tradition that drove consumers to seek out organic produce in the first place. The picture isn’t any better in Canada, according to the Canadian Organic Growers Association, where only 1 percent of the food grown there is organic. This of course raises the question as to how we are going to satisfy this increasing consumer demand. In a word: imports. We already import more than 10 percent of the organic food we eat. But perhaps the figure of greater interest is that we consume 42 percent of the worldwide organic food supply, leaving only 58% for world’s non-U.S. residents. In this enlightened era in which we understand the downside of processed foods, chemical residue and the portent of global warming, it’s hard to understand why we don’t muster our great resources and legendary spirit to launch a program to address these issues—like JFK’s Apollo Project, which put a man on the moon in under a decade using computers less powerful than are commonly found on our desktops today. While we ponder the question, there are people of good will and strong conviction who are working, albeit with limited resources, to do something about it. one group is working on remineralizing the earth. We are proud to be supporters and friends and we think you will find their concept as exciting as we do. -Peter Gillham – editor.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1568) Complete Liver Cleanse
Date:
April 19, 2007 04:17 PM
Complete Liver Cleanse Technical Data Sheet DESCRIPTION: The liver performs over 500 functions, including metabolizing carbohydrates and proteins, synthesizing and storing vitamins, and regulating hormones – naming just a few. To do this job, the liver is also required to be exposed to potentially harmful toxins and chemicals, every day. One way to support the liver is through periodic supplementation with the proper balance of herbal ingredients, phytosterols, and fiber. Complete Liver Cleanse is a convenient, multi-ingredient formula that supports overall liver health and detoxification. Complete Liver Cleanse: Includes ingredients for various aspects of liver and gallbladder support: -Herbal ingredients that support liver and gallbladder health -Detoxifying ingredients that keep bound toxins from being reabsorbed -Phytosterols to block cholesterol absorption in the intestines -Fiber that moves cholesterol and toxins out of the body -Oat beta-glucan fiber with up to 4 times higher viscosity than other beta-glucan Fibers -Simple, two week liver cleanse program FORMULA: Each 3 capsules contain: Calcium (as calcium D-glucarate) 13 mg Proprietary PuraFiber Blend: 1 mg Viscofiber Oat B-Gucan Concentrate, phytosterols (beta sitosterol, campesterol, stigmasterol, brassicasterol, and other plant sterols), and glucomannan Milk Thistle (Silybum marianum) Fruit Phytosome 220 mg One part Milk Thistle Extract, standardized to contain 80% Silymarin bound to two parts phosphatidylcholine (soy) using a patented process Burdock (Arctium lappa) Root Extract 4:1 100 mg Calcium D-Glucarate 100 mg Boldo (Peumus boldus) Leaf Extract 2:1 75 mg Turmeric (Curcuma longa) Rhizome Extract 50 mg Standardized to contain 90% curcuminoids Dandelion (Taraxacum offinale) Root Extract 4:1 50 mg Artichoke (Cynara scolymus) Leaf Extract 30 mg Standardized to contain 13-18% caffeylquinic Acids calculated as chlorogenic acid Contains no: sugar, salt, yeast, wheat, dairy products, artificial coloring, artificial flavoring, ingredients of animal origin, or preservatives. This product contains natural ingredients; color variations are normal. Other ingredients: See label for most current information Viscofiber is a registered trademark of Cebena Bioproducts, Inc. The use and composition of the Viscofiber proprietary formula is protected by patients and patent applications filed in the This product contains calcium D-glucarate, the use of which is licensed from Applied Food Sciences, LLC, and protected by HOW DOES IT WORK? The Liver Every day, the liver must process an almost unbelievable amount of blood – at a rate of three pints every minute. All the while, the liver performs over 500 physiologic functions, including protein and glucose synthesis, carbohydrate metabolism, vitamin and mineral storage, synthesis of clotting factors, urea formation, metabolism of medications, and the production of bile. The liver also assists in hormonal regulation, blood glucose control, and other regulatory functions. Harmful substances that have been neutralized by the liver are carried to the intestines and kidneys for excretion. They are transported by bile, a greenish, watery solution that is synthesized, and continuously being excreted, by the liver. Stored in the gallbladder, a small sac cupped in the under surface of the liver, bile is also required for the digestion of dietary fats. However, in the case of toxins, bile is primarily an early transporter of the toxic compounds to the intestines, where they can be bound to fiber that helps transport them out of the body. Environmental toxins, including lipid (fat) soluble toxins, are broken into water-soluble components by bile to be excreted through the kidneys or colon. Liver Detoxification Detoxification refers to the process of excreting potentially harmful compounds that are both generated by the body and acquired through exposure to the environment. In the body, toxins are generated as by-products of cellular metabolic processes. Examples include dead and digested bacteria, hydrogen peroxide, cellular debris, and carbon dioxide. The Environmental Protection Agency has determined that the amount of environmental toxins in the air, groundwater, and soil has increased significantly in the last 40 years. In fact, the use of pesticides has doubled every ten years since 1945. Americans are increasingly exposed to heavy metals, pesticides, fossil fuel emissions, sulfur oxides, hydrocarbons, and other harmful chemicals. The Environmental Protection Agency reports that traces of toxic chemicals can now be found in nearly every American. Herbal Liver Support One of the major components in Complete Liver Cleanse is its milk thistle extract, standardized to contain 80% silymarin, the plant’s most bioactive compound. Milk Thistle provides support, at a cellular level, for healthy liver function. A patented delivery system, known as the Phytosome process, provides superior absorption of the milk thistle extract. Silymarin, a key compound found in milk thistle, is a mixture of flavonoids with a long history of liver support. Silymarin supports the health of Kupffer cells, specialized liver cells responsible for removing bacteria, old blood cells, and other foreign matter from the liver’s blood supply. Silymarin scavenges free radicals (superoxide anion radical and nitric oxide) produced by activated Kupffer cells, supports healthy leukotriene levels, and supports glutathione production that is used in detoxification. Silymarin also supports the health of hepatocytes, highly versatile liver cells with unique physiologic functions. Studies of silymarin have demonstrated that it supports the health of the hepatocyte outer membrane, which is crucial to the liver’s detoxification processes. Silymarin also supports the healthy regenerative ability of the liver through support of protein synthesis in the hepatocytes. Phytosome Process A special, patented proves known as Phytosome enhances the absorption of milk thistle in Complete Liver Cleanse. The Phytosome process pairs herbal ingredients with phosphatidylcholine molecules. Phosphatidylcholine is a naturally occurring substance found in soybeans, egg yolks, and some vegetables. In the body, phosphatidylcholine is an important building block of cell membranes. When milk thistle (or other herbs) are bound with phosphatidylcholine, the phosphatidylcholine molecule facilitates absorption through the intestines into the bloodstream. Research has shown increased blood and serum levels for phytosome herbs in comparison to the individual herb alone. To test whether binding an herb with phosphatidylcholine increased its bioavailability, researchers gave volunteers identical amounts of either milk thistle alone, or milk thistle phytosome. The researchers then took blood sample from the participants and measured the level of silybin (a key compound in milk thistle). The measurements showed that silybin levels in participants taking the phytosome form of milk thistle were higher, and that silybin was detected for a longer time, than those who took milk thistle without the phytosome delivery system. Other Herbal Liver Supportive Ingredients Herbal extracts are often at their best when they are working synergistically – that is, when different constituents of each plant work together and support each other. Complete Liver Cleanse contains a variety of herbal extracts that have noted benefits for supporting the body’s healthy bile flow and free-radical scavenging effects. These ingredients provide a wide spectrum of liver supportive benefits. For instance, dandelion root extract supports healthy bile flow from the gallbladder. Burdock Root: Burdock is originally native to Europe and Asia, but was introduced to Burdock root (Arctium lappa) supports the natural physiologic processes of organs involved in detoxification and elimination: notably, the liver, kidneys, and intestines. Boldo: Bolodo (pemus boldus) is a small evergreen native to South America, but naturalized to southern In scientific studies, boldo appears to have strong free-radical scavenging ability, mostly attributed to the catechin and flavonoids content of its leaves. In a clinical study, boldo also appears to relax smooth muscle and support intestinal transit time. Artichoke Leaf extract specifically supports healthy bile production in the liver and healthy gastrointestinal function in general. Research into artichoke’s gastrointestinal supportive properties has included at least three clinical trials. Artichoke’s role in supporting healthy cholesterol levels within normal limits has also been investigated. Turmeric: Turmeric (Curcuma longa) is a perennial shrub native to southern More recently, turmeric has been investigated for its support of healthy bile secretion, and pancreatic and gastric function. In a scientific study, dietary curcuminoids derived from turmeric supported healthy lipid metabolism and cholesterol levels already within normal limits. Curcumin has also been shown in scientific studies to enhance the activity of glutathione S-transferase - an enzyme responsible for linking glutathione (one of the body’s natural antioxidants) with toxins to help remove them from the body. In this way, it provides additional support for healthy liver function. Detoxification Calcium d-glucarate: The process of detoxification is the breakdown and excretion of substances that are no longer needed or may be harmful to the body. One of the ways in which the body excretes hormones and toxins is by binding them to glucuronic acid in the liver, and then excreting this compound in the bile. However, this process can be disrupted by B-glucuronidase, an enzyme that is produced by intestinal bacteria. This enzyme has the ability to break (uncouple) the chemical bond established by glucuronic acid. This action releases the bound toxins, which are then reabsorbed into the body instead of being excreted. Calcium D-Glucarate is the calcium salt of d-glucaric acid. It is found in both the human body, and in some plant sources, including broccoli and oranges. Calcium d0glucarate enhances the body’s detoxification systems by inhibiting the actions of beta-glucuronidase. This helps decrease the portion of active compounds that could be hazardous to the body. Phytosterols Cholesterol is a waxy, fat-like substance that is vital to fat digestion, cell structure, nerve insulation and hormone production. Cholesterol comes from two sources: dietary or “exogenous” cholesterol absorbed in the intestine, and “endogenous” cholesterol formed mostly by the liver and stored in the gallbladder. Cholesterol occurs in two forms known as lipoproteins. Lipoproteins act as transports that carry fat s to and from the cells. High-density lipoprotein (HDL) carries low lipid density cholesterol (LDL) away from arterial walls and returns it to the bloodstream. LDL then travels back to the liver, which processes and eliminates it. While high levels of HDL cholesterol is desirable, high amounts of LDL cholesterol is not supportive of optimal health. LDL-cholesterol is both synthesized in the body, or absorbed into the bloodstream through receptor sites in the intestines. Think of these receptors as “parking spaces” for cholesterol. As it happens, the liver can receive up to 500 mg per day of cholesterol from intestinal absorption. (It can also produce as much as 1000 mg per day). One way to help reduce the absorption of LDL cholesterol molecules it to occupy their “parking places” in the intestines. Phytosterols in Liver Cleanse are essentially the “fat” of plants. They’re found in nuts, corn and rice and are some of the “good” fats associated with the benefits of olive oil, flaxseed oil and other healthy oils. The structure of phytosterols is so similar to cholesterol that they fit perfectly in the specially-shaped intestinal parking spaces that LDL-cholesterol would normally occupy. Taken with, or just before meals, phytosterols block the cholesterol receptor sites so that cholesterol is excreted from the body rather than absorbed. Phytosterols also have the additional role of helping promote healthy bile salt excretion in the intestines. The phytosterol blend in Complete Liver Cleanse can help minimize the absorption of cholesterol from high-protein food sources, help retain healthy cholesterol levels that are within normal limits, and move bile sat through the digestive system. Fiber and detoxification Fiber plays a key role in the removal and excretion of intestinal toxins in detoxification. Only fibers that can effectively bind toxins will be successful in eliminating these harmful substances. Due to the unique benefits of individual fibers, the best binding, removal, and elimination effects are noted when combining different fiber types. Complete Liver Cleanse contains a combination of oat beta-glucan and konjac fiber that has been shown in scientific studies to bind to bile salts. Dietary fibers are complex mixtures of cellulose, hemicellulose, pectin, mucilage, and gums, which are resistant to digestive fluids or enzymes – that is, they aren’t absorbed into the bloodstream. So, while fiber itself doesn’t necessarily provide nutrients, it does promote laxation and modulate gastric and intestinal physiology. Intestinal flora that normally reside within the colon utilize fiber as a medium for microbial fermentation, resulting in the synthesis of the vitamins, vitamin K and biotin, and the formation of short chain fatty acids, or SCFA. SCFA have a simple, but important job: to be absorbed by the colon mucosa, increasing fecal matter bulk and providing energy. Fiber has been demonstrated in numerous clinical studies to provide support of gastrointestinal, cardiovascular, immune, and endocrine function health. Complete Liver Cleanse also features two unique fibers to promote detoxification – konjac and oat beta-glucan. Konjac: Konjac, (Amorphophallus Konjac) is a tuber native to As a fiber, konjac has shown positive results maintaining healthy cholesterol levels within normal limits in clinical studies. This beneficial effect is due to konjac’s ability to boost excretion of bile acid. Oat beta-glucan: Oat beta-glucan has been a widely studied fiber source for supporting healthy cholesterol levels within normal limits. In a randomized clinical study, oat beta-glucan showed support of healthy HDL/LDL ratios already within normal limits in individuals over a three week trial. Closely linked to cholesterol, oat beta-glucan has also been studied for its support of healthy bile excretion. Fiber has benefits beyond maintaining healthy cholesterol levels already within normal limits. It also contributes to healthy blood sugar levels already within normal limits. In a double-blind, clinical study, the oat beta-glucan fiber used in Liver Cleanse was shown to have 4 times higher viscosity than another high concentrate beta-glucan fiber. Viscosity – the resistance to flow – is an important factor in beta-glucan, and all fiber. Water, for instance, would have a low viscosity, because it provides very little resistance to movement. Fiber, on the other hand, should have a higher viscosity in order to maximize its transit time through the GI tract, providing a gentle “scrubbing” on the intestinal walls. Therefore, the higher the viscosity, the greater the potential benefit. RECOMMENDATIONS: Three capsules in the morning and three capsules at bedtime for 14 days. LABEL PRECAUTION: Warnings: Do not use if you know or suspect you have an obstructed bile duct or problematic gallstones. If pregnant, nursing or taking prescription drugs, consult your healthcare practitioner prior to use. Keep out of reach of children.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1517) Benefits of Best Alpha Lipoic 35!
Date:
February 12, 2006 03:11 PM
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1217) Super Cortisol Support Fact Sheet
Date:
December 08, 2005 07:04 PM
Super Cortisol Support Fact SheetNeil E. Levin, CCN, DANLA 10/1/05LIKELY USERS: People under a lot of stress; People who suffer from stress-related eating; People who may have metabolic syndrome (Syndrome X); KEY INGREDIENTS: Relora®13, Rhodiola14-20, Reishi 21-24, Green Tea Extract25-32, Holy Basil, Ashwaganda, Banaba, Pantothenic Acid, Calcium Ascorbate, Magnesium, Lecithin, Chromium MAIN PRODUCT FEATURES: NOW® Super Cortisol Support is an herbal and nutritional formula designed to support healthy adrenal function and maintain healthy cortisol levels. The adrenal glands help the body respond and adjust to stress generated from both internal and external forces. Under chronic stress, cortisol can be overproduced, resulting in weight gain and difficulty in managing healthy blood sugar levels. Super Cortisol Support combines adaptogenic herbs with Chromium, Corosolic Acid and Relora® to help the body manage the negative effects of stress such as abdominal obesity, overeating and low energy levels. ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: Reishi, Rhodiola, Ashwaganda, and Holy Basil support healthy energy levels throughout the day1-6. Reishi, Rhodiola, Ashwaganda, and Holy Basil support healthy immunity1-9. Along with Chromium, and Corosolic Acid, these herbs also help to support healthy serum glucose levels1-12. Relora® has been included in this formula to alleviate symptoms associated with stress such as irritability and nervous tension13. This formula is recommended by Hyla Cass, MD. This is the first Cortisol formula to use Relora®, a natural proprietary blend of a patented (U.S. Patent No. US 6,582,735) extract of Magnolia officinalis and a patent-pending extract from Phellodendron amurense. Relora® was developed as an ingredient for dietary supplements and functional foods that could be used in stress management and for stress-related appetite control. This patented blend of plant extracts is the result of screening more than fifty plant fractions from traditional plant medicines used around the world. Relora® has excellent stress management properties without causing sedation. Overweight adults may have excessive abdominal fat due to stress-related overeating. Relora® appears to maintain healthy hormone levels in stressed individuals and act as an aid in controlling weight and stress-related eating.33 SERVING SIZE & HOW TO TAKE IT: One capsule, two to three times a day. COMPLEMENTARY PRODUCTS: Holy Basil, Green Tea, L-Theanine, Licorice Root, Vitamin C, Eleuthero Root, Pantothenic acid CAUTIONS: None. SPECIFIC: Some of these ingredients may support the body’s blood sugar controls, so people taking blood sugar medications should inform their physician before using Super Cortisol Support, and their glucose should be monitored when taking this formula so their medication strength can be modulated appropriately to avoid an overdose of medication. No side effects have been noted for this dosage of Relora®. GENERAL: Pregnant and lactating women, children and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
1. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV (2000) Phytomedicine 7(2):85-89.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1003) Vitaberry Plus + Super Fruit Antioxidant
Date:
December 07, 2005 05:43 PM
Vitaberry Plus +™ Super Fruit AntioxidantBy Nilesh Patel, NOW Quality Assurance, April 20, 2005 Why are FRUITS AND VEGETABLES important? “Diets rich in FRUITS AND VEGETABLES may reduce the risk of some types of cancer and other chronic diseases.”- National Cancer Institute. OXYGEN AND ANTIOXIDANTS As we all know, “Oxygen is critical to life,” but is itself a double-edged sword. While oxygen is necessary to sustain life and for natural defense against microbes, too much oxygen in our cells can lead to the production of “free radicals” (mitochondrial respiratory chain) or ROS (Reactive Oxygen Species). Free radicals come in many forms - singlet oxygen, hydrogen peroxide, superoxideperoxynitrite, to name a few - but all have one commonality. Each has an unpaired (unbalanced) electron, a situation it remedies by stealing an electron from a stable molecule. This sets off a domino effect of oxidation, a chain reaction that usually ends up damaging cellular integrity and compromising overall health. Nature has a defense system in place to protect these processes in the form of antioxidants. Whether endogenous (produced by the body, such as liver enzymes, SOD, coenzymes and sulfur-containing compounds) or exogenous (obtained through the diet, such as vitamins C & E, bioflavonoids, carotenes, etc.), antioxidants “quench” free radicals by donating an electron to stabilize a molecule, thus controling the chain reaction and stopping the oxidation “domino effect”. ANTIOXIDANT-RICH FOODS Research suggests that eating plenty of foods high in antioxidants helps to slow the processes associated with aging and protect against many chronic diseases. Maximizing one’s antioxidant power will enhance overall health. Fruit and vegetables contain both nutritive and non-nutritive factors that can affect oxidative damage and enzymatic defense and might contribute to redox (antioxidant and prooxidant) actions. A new “6-a-day” study looked into the effects of fruits and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers by The Danish Institute for Food and Veterinary Research in Denmark. The study found that fruits and vegetables increase erythrocyte glutathione peroxidase activity and resistance of plasma lipoproteins to oxidation more efficiently than do the nutritive factors (vitamins and minerals) that the fruits and vegetables are also known to contain. Certain berries, such as blackberries, also contain salicylates, which are also linked to heart health and prevention of atherosclerosis. The protective effects of fruits and vegetables intake on both heart disease death and deaths in general have previously been demonstrated but researchers at the Human Nutrition Research Center on Aging at Tufts University, Boston. Quercetin is an anti-oxidizing flavonoid found in many berries (such as cranberries, bilberries, blueberries, strawberries, etc.) and can prevent CVDs (coronary vascular diseases), according to a recent Finnish study. All these natural plant polyphenols are responsible for the colors of many red and purple berries, fruits, vegetables and flowers. GOVERNMENT GUIDELINES The new federal guidelines released earlier this year by the U.S. Department of Health and Human Services (HHS) and U.S. Department of Agriculture (USDA) recommend eating more fruits and vegetables, combined, than any other food group -- five cups or about 10 servings a day for most adults. The amount of fruits and vegetables recommended has increased for men and women of every age. “Fruits and vegetables are the "good news" story of the new Dietary Guidelines for Americans for food-loving consumers, the industry and America's public health”, stated the Produce for Better Health Foundation (PBH). Eating a variety of colorful phytochemical-rich fruits and vegetables has been associated with lower risk of some chronic diseases such as cancer and heart disease. Many authoritative organizations such as the National Cancer Institute and The American Heart Association recommend getting phytochemicals from whole foods, such as fruits and vegetables, rather than from individual component supplements. The Scottish government is promoting healthy eating through a scheme designed to increase purchasing of fruit and nutritional foods. Scottish health minister Andy Kerr said, "This initiative shows that healthy eating can be good for customers and good for business." Scottish women are said to have the highest rates of death from lung cancer in the world as well as the highest rates in Europe for coronary heart disease. They also have low consumption of fruits and vegetables, shown in studies to help protect against some cancers and benefit heart health. ROS (Reactive Oxygen Species) Free radicals and oxygen free radicals play an important role in the development and progression of many brain disorders such as brain injury, neurodegenerative disease, and Down syndrome. Oxidative stress is an important factor in the etiology and pathogenesis of diabetes & is also linked to other host of degenerative health conditions. Fortunately, antioxidants are available to support the body’s defense and fight disease and aging. Examples of “Fast acting antioxidants” in the body (serum) are: uric acid (polyphenols), ascorbate, bilirubin, vitamin E (the later two are lipid soluble). Examples of “Slow acting antioxidants” are glucose, urea nitrogen etc. In short, free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated as by-products of normal cellular metabolism. Their deleterious effects are minimized in vivo (in the body) by the presence of antioxidant systems. How do Antioxidants work? Antioxidants are substances in plants that help maintain health. Antioxidants protect against damage to cells caused by too many “free oxygen radicals,” which form because of the effects of oxidation. Smoking, sunlight, heavy exercise, and pollution all increase oxidation in the body. Most people would benefit by eating more (five to nine or more servings) fruits and vegetables & colorful plant foods, such as purple, dark green, yellow, orange, blue, and red ones, each day. These have healthful pigments along with antioxidant nutrients such as vitamin C, carotenoids, beta-carotene, lycopene, lutein, zeaxanthin, vitamin E, selenium, flavonoids, and other beneficial substances. There are numerous ways in which these antioxidants affect, but can be explained in two groups: Alpha (a) Effects: This refers to the scavenging or neutralizing of free radicals. These effects do not change the way humans (or animals) feel. There are also no noticeable health, psychological or emotional benefits. While there are no obvious changes, increased total antioxidant intakes are associated with decreased tumor rates, prevention of heart attacks and increased longevity. Beta (ß) Effects: These are the changes on health, psychological or emotional state that you or others will notice. In this case, the antioxidant is affecting metabolic processes (enzymes) with consequent changes in the physical (improvement in joint movements, improved skin condition, tissue damage recovery), emotional (better ability to cope with stress) or psychological state (increased alertness). The ORAC value Because most of the active nutritional components in fruits and vegetables are antioxidants, accurate measurement of antioxidant activity serves as a good indicator of potential health benefit. Scientific opinion runs high that ORAC (Oxygen Radical Absorption Capacity) will eventually become a government standard of reference for overall daily fruits and vegetables intake. ORAC units are a measurement of the ability of food to stop oxidation. It is most generally expressed in terms of Trolox equivalent per gram (µmole Trolox equivalents (TE)/g). POPULATION DATA A survey done by the National Research Council indicates that only 10% of the US population consumes the recommended five servings of fruits and vegetables per day. The equivalent to eating 5 mixed servings of fruits and vegetables per day is about 1,670 ORAC units. Based on scientific evidence it is suggested that daily antioxidant intake should be increased to between 3,000 and 5,000 ORAC units per day, per human subject, in order to reach a significant antioxidant capacity in blood plasma and other tissues. WHAT IS NOW DOING TO HELP? In accord with our mission, “To provide value in products and services that empower people to lead healthier lives,” NOW® Foods is introducing an ALL-FRUIT-DERIVED antioxidant product called VitaBerry Plus +™ Super Fruit Antioxidant Vcaps (vegetarian capsules) (product number #3336). At time of manufacture this product provides an ORAC value of at least 2,500 units per serving from a full-spectrum antioxidant blend of fruits containing phytochemicals and phenolic compounds such as anthocyanins, proanthocyanins, chlorogenic acid, ellagic acid, quinic acid, resveratrol , many organic acids, resveratrol and vitamin C. VitaBerry Plus +™ is formulated with VitaBerry™ Hi-ORAC Fruit Blend [a proprietary blend of fruit extracts & concentrated powders containing Wild Blueberry (Vaccinium angustifolium) extract, Grape (Vitis vinifera) & Grape seed extract, Raspberry (Rubus idaeus) & Raspberry seed extract, Cranberry (Vaccinium macrocarpon), Prune (Prunus domestica), Tart Cherry (Prunus cerasus), Wild Bilberry (Vaccinium myrtillus) extract & Strawberry (Fragaria virginia)], Hi-Active™ Orange (Citrus sinensis) and Pomegranate (Punica granatum) min. 40% ellagic acid fruit extract. One gram of VitaBerry™ Hi-ORAC Fruit Blend provides at least 6,000 ORAC units (i.e., µmole Trolox equivalents (TE)/g). (Also watch for an upcoming antioxidant product from NOW called Enzogenol® (Pinus radiata bark extract from New Zealand) with Rutin (a flavonoid from South American fruit of Dimorphandra mollis) and Grapeseed extract. IS IT EFFECTIVE? Total ORAC value includes both lipophilic and hydrophilic components. VitaBerry Plus +™ contains only water/hydroethanol based extracts and concentrated (100:1 to 125:1) freeze-dried fresh fruit blends, so the lipophilic ORAC value is mere 2-4% of the total ORAC value. Glutathione peroxidase is a selenium-containing enzyme that decreases cell death from brain injuries. It also acts as a critical first-line antioxidant defense on the airway (respiratory) epithelial surface against ROS and RNS (reactive nitrogen species. Genetics research has found that the glutathione S-transferase gene controls the onset of Alzheimer’s, Parkinson’s disease etc. Taking glutathione (GSH) itself as a supplement does not boost cellular glutathione levels, since it breaks down in the digestive tract before it reaches the cells. So glutathione precursor dietary supplements (such as NAC and GliSODin), along with fruits and vegetables, are effective in boosting intracellular levels of GSH. The lungs have a defense system against the ROS oxidants consisting of low molecular weight antioxidants such as GSH and intracellular enzymes such as SOD, catalase and glutathione peroxidase to protect against the toxic effects of oxidants generated within the cells. Some of the primary effects of VitaBerry Plus +™ against the common reactive free-radical species or ROS are as follows: - Superoxide dismutase-SOD (destroys Superoxide radicals),- Catalase (neutralizes peroxides), - Functions similar to reduced Glutathione (GSH), - Glutathione peroxidase enzyme (detoxifies peroxides, using GSH as a reducing agent), - Functions similar to Glutathione S-transferase (GST), - Nullifies Superoxide-generating NADH/NADPH oxidase system In conclusion More concentrated than fresh berries, with over 6000 ORAC units per gram, VitaBerry Plus +™ provides consumers with the antioxidant power of almost 15 servings per day of FRUITS AND VEGETABLES ina convenient vegetarian capsule form! VitaBerry™ PLUS +™ (# 3336) provides a powerful, convenient way to supplement diets that do not include sufficient fruit and vegetable antioxidants Selected References: USDA/HHS guidelines report at: etaryguidelines/dga2005/document/
ls.com/proprietary/pdf/VitaberryBrochure.pdf g Kaplan M., Hayek T. , Raz A., Coleman R. and Aviram M. Pomegranate juice supplementation to apolipoprotein E deficient mice with extensive atherosclerosis reduces macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 131: 2082-2089 (2001) Lars O Dragsted et. al., The 6-a-day study:effects if fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. American Journal of Clinical Nutrition, Vol. 79, No. 6, 1060-1072, June 2004 Fuhrman B. and Aviram M. Polyphenols and flavaonoids protects LDL against atherogenic modifications.In: Handbook of Antioxidants Biochemical, Nutritional and Clinical Aspects, 2nd Edition. Cadenas E & Packer L (Eds.) Marcel Dekker, NY(Pub.). 16:303-336 (2001) Wood, Jacqueline, et al. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry 77 (2002) 155-161 Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. Free Radical Research 36 (Supplement 1): 71-72 (2002) Jennifer Schraag, Antioxidants: Nature’s Way of Balancing Life. HSR Health Supplement Retailer, Vol. 11, No. 2, 24-27, February 2005 com/news/printNewsBis.asp?id=58665 com/news/printNewsBis.asp?id=58697
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=992) TestoJack 100
Date:
December 06, 2005 05:58 PM
Powerful Testostersone Support for Virility, Stamina and Endurance TestoJack100 is an exciting new testosterone-support supplement from NOW, and has already generated quite a buzz in the health and natural product communities. Fueled by a perfectly balanced union of Tribulus terrestris, ZMA and highly anticipated LJ100, TestoJack100 was specifically designed to help support male virility and reproductive health on several levels. Individually, each component in testojack 100 offers unique beneficial effects. Together, they account for one of the most powerful natural male virility supplements ever to hit the market. A number of clinical and non-clinical studies have shown that the active extracts found in Testojack 100 may:
LJ100 was discovered and is still widely promoted by famed medicine hunter and author Chris Kilham.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=972) Benefits of Alpha Lipoic Acid
Date:
October 13, 2005 05:08 PM
Benefits of Alpha Lipoic Acid
Alpha-lipoic Acid––the "Ideal Antioxidant"
The antioxidant potential of a substance is based on a number of criteria, including: The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes.
As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3 DHLA-regenerates vitamin C, vitamin E and glutathione Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants. DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7 Alpha-lipoic Acid and Blood Sugar Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10 Scientific References 1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50. 2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63. 3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31. 4. Serbinova, E. Maitra, I., Packer, L. The synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21. 5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561. 6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637. 7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87. 8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4. 9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14. 10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=840) LIFE FORCE MULTIPLE - Essential Nutrients to Support Your Low Carb Lifestyle..
Date:
June 29, 2005 10:39 AM
Taking care of your body is an especially important challenge in today’s stressful and hectic world. Choosing a low carb lifestyle is an increasingly popular way to seek better health. In fact, there are approximately 30 million U.S. adults counting their carbs right now. While effective for weight control and therefore having positive health effects, low carb approaches can also result in serious nutrient imbalances. Thus, adding the right multiple to your low carb approach is an enormously important next step for your good health. LIFE FORCE MULTIPLE, the top-ranked and award–winning multiple from Source Naturals, replenishes these nutrients and provides compounds that will help your body process the increased proteins and fats better while you are restricting carbs. Low Carb Benefits Restricting carbs can have many health benefits. And lowering your intake of refined simple carbs, such as sugar and white flour, can help you promote healthy blood sugar and insulin levels, which is critical for your good health. Insulin is used to move the glucose from carbs into your cells for energy. Ingesting too many refined carbs can greatly reduce your body’s ability to use insulin well, which can lead to short and long-term health concerns. Replenish Nutrients with LIFE FORCE LIFE FORCE contains optimal levels of many nutrients that might be deficient in low carb meals. Counting carbs can lead to restrictions of nutrient dense foods such as dairy products, grains, fruits and vegetables. LIFE FORCE contains many of the same protective antioxidants, vitamins and minerals as fruits and vegetables, including beta-carotene, vitamin C, vitamin E, flavinols, magnesium and selenium. It also contains high levels of the same vitamins found in grains, including all of the B vitamins, to support your body’s healthy energy metabolism. And it contains nutrients found in dairy products such as calcium, potassium, vitamin A and vitamin D. Support Healthy Fat and Protein Consumption with Life Force Low carb lifestyles mean higher consumption of proteins and fats. Unfortunately, there are artery, heart, colon and many other health concerns associated with meals that are high in fat and protein and low in fiber and produce. However, the nutrients in LIFE FORCE can help you better process eating this way. LIFE FORCE contains high levels of protective fat-soluble antioxidants such as alpha lipoic acid, ascorbyl palmitate (vitamin C ester) and vitamin E to protect your body from the free radicals generated by consuming more fats. It also contains many nutrients for liver health, such as silymarin, CoQ10, N-Acetyl Cysteine and turmeric to help support the fat metabolism your liver is responsible for. LIFE FORCE also contains a high level of the B vitamin biotin, which aids in fat, protein and energy metabolism. Restricting simple carbs can do much more than help you maintain a healthy weight; it can also be the foundation for maintaining good health throughout your long life. But you need to develop a thoughtful holistic strategy for success. When you integrate LIFE FORCE MULTIPLE into your wellness plan, then you can benefit from decades of clinical research about the nutrients your body needs to support optimal health and a low carb lifestyle, long before this information becomes part of mainstream health recommendations. Join this wellness revolution by adding LIFE FORCE to your strategies for health and allow yourself to start feeling energized today!
References
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=521) Life Force - The Energy Activator
Date:
June 29, 2005 10:35 AM
Don’t Be Confused About Multiples – Get the Top-Ranked Multiple That Scores 100% We can help you decide how to pick the most advanced daily multiple for your wellness. Listen to the experts. Source Naturals LIFE FORCE MULTIPLE was honored as a leading formula in an independent scientific analysis of 500 multiples, ranking higher than any other national brand. Lyle MacWilliam, author of the Comparative Guide to Nutritional Supplements (ide.com) ranked multiples based on criteria developed from the published recommendations of the most renowned nutritional authorities: Phyllis Balch, C.N.C.; Michael Colgan, Ph.D.; Earl Mindell, Ph.D.; Michael Murray, N.D.; Richard Passwater, Ph.D.; Ray Strand, M.D.; and Julian Whitaker, M.D. Source Naturals’ success in this rigorous scientific analysis reflects our Bio-Aligned™ formulation method. LIFE FORCE goes deep to the underlying cause of health imbalances by supporting multiple body systems. And now, based on the latest scientific research, we have improved the formula by adding even more antioxidants and other cutting-edge ingredients. According to Lyle MacWilliam, “Source Naturals made a top ranked multiple even better!” And based on Lyle’s analysis of the new formula, LIFE FORCE is now the highest rated multiple of any evaluated in the current edition of this guide, scoring a 100% rating. Bio-Align™ Yourself with Life Force LIFE FORCE MULTIPLE was chosen as one of America’s most elite and comprehensive multiples, as reported in the Comparative Guide to Dietary Supplements by Lyle MacWilliam, 3rd ed. LIFE FORCE received this acknowledgement by nutrition experts because it is uniquely effective. This Bio-Aligned Formula™ goes beyond ordinary multiples that simply replace nutrients missing from the diet. LIFE FORCE provides key organ-specific nutrients to support your body’s energy generation, heart, brain, immune system, musculoskeletal system, skin, liver, eyes, and more. When all your body systems function in harmony, everything in life comes together. Your mood is positive, your mind is clear, you’ve got energy in your step—that’s your LIFE FORCE working for you. Get Ahead with Activated Energy and a Healthy Metabolism Your metabolism determines how much you weigh, how energetic you feel, and the effective functioning of all your systems. LIFE FORCE is a rarity – a unique multiple containing an incredible number of nutrients at the potency levels that truly support your healthy metabolic function. For example, it contains coenzyme Q10, which plays a crucial role in cellular energy production. CoQ10 is a vital intermediate in the electron transport chain, one of the body’s energy production cycles, which converts glucose, or blood sugar, into ATP (Adenosine Triphosphate), a high energy molecule that is the body’s “energy currency.” LIFE FORCE also supplies alpha-lipoic acid and the potent R-lipoic acid form of lipoic acid, which are both referred to as the universal antioxidants and important intermediaries in the Krebs cycle, another energy production cycle. LIFE FORCE also contains tyrosine and iodine, both precursors to thyroid hormones. These hormones regulate key metabolic functions like heart rate, digestive function, weight management and energy levels. No discussion of metabolism would be complete without mentioning the B vitamins and their coenzymated forms, such as thiamin cocarboxylase, riboflavin mononucleotide, and the methylcobalamin form of vitamin B- 12. These critical vitamins and their immediately bioavailable coenzymated forms are formulated to play critical roles in thousands of enzyme reactions that promote carbohydrate metabolism, energy production, and the mental functions that invigorate and activate you as you move through your busy days. And now green tea extract with EGCG (Epigallocatechin Gallate) has been added to the formula for added metabolic support. Protect Your Heart and Circulatory System The amazing muscular organ that is your heart beats more than 100,000 times a day, 365 days a year, promoting vitality and alertness by constantly oxygenating our tissues. LIFE FORCE supports your cardiovascular system with antioxidant coenzyme Q10, which helps support heart muscle metabolism. LIFE FORCE also contains the minerals potassium and magnesium, electrolytes vital for healthy heartbeat and heart function, and the herb hawthorn, a rich source of antioxidant flavonoids, which has traditionally been used as a heart tonic. LIFE FORCE also supplies vitamins B-6, B-12 and folic acid to help maintain healthy homocysteine levels and vitamin K to support healthy circulation. Unlike common multiples, it supports cholesterol wellness, circulatory health and antioxidant cardiovascular protection, with both the typical d-alpha form of vitamin E but and the more potent and effective gamma-tocopherol and similarly structured tocotrienols. Skin and Musculoskeletal Support LIFE FORCE furnishes nutrients to build healthy bones, muscles and skin. We all know that calcium and magnesium are crucial for bone health, but many people don't know that there are a variety of nutritional cofactors that help build bone, such as vitamin D (which enhances calcium absorption and utilization), boron, manganese and copper. LIFE FORCE also supplies vitamin C and copper, necessary nutrients for collagen production (collagen is a key constituent of connective tissue in joints, skin and other areas), and the cutting-edge nutrient methylsulfonylmethane (MSM), an assimilable form of the mineral sulfur, used by the body to build and maintain connective tissues, including joint cartilage, hair, skin and nails. Additional nutraceuticals to support healthy skin include DMAE bitartrate, CoQ10, and alpha lipoic acid. LIFE FORCE also now includes rutin, quercetin, green tea extract and 65% more turmeric extract for your joint comfort. Brain and Nerves Nutrition The hectic pace and constant demands of life can keep our pulse racing, our nerves jangling and our temples throbbing. Our nervous systems are crying out, “Help!” LIFE FORCE provides that help. LIFE FORCE supplies the most highly bioavailable and bioactive forms of the amino acid tyrosine – the N-acetyl form and the acetyl-L form. Tyrosine is an important precursor to epinephrine and norepinephrine (collectively known as the catecholamines), which helps you respond to stress. It also contains high doses of vitamins C and B-6, required by the adrenal glands to produce the catecholamines. In addition, LIFE FORCE delivers the full spectrum of B vitamins, all important for healthy nervous system function. Now LIFE FORCE also contains a more bio-available form of tyrosine, acetyl-L-Tyrosine. And LIFE FORCE contains Neuroceutical® nutrients that support healthy brain function by furnishing DMAE and choline. Both are precursors to the important neurotransmitter acetylcholine and are important for memory focus and muscular movement. Choline is also a precursor to phosphatidylcholine, an important constituent of the cellular membranes that surround and protect our brain cells. In addition, LIFE FORCE contains the renowned herb Ginkgo biloba and now even more grape seed extract, both effective antioxidants that can prevent lipid peroxidation, which is critically important for the high amounts of fatty tissue in the brain. LIFE FORCE—good food for the brain. Immune Defense LIFE FORCE MULTIPLE supports your immune system, so you can feel your best through the seasons. LIFE FORCE contains the immunosupportive nutrient vitamin A, which fosters cell-mediated immunity and protects the epithelial linings of the respiratory and digestive tracts. Two forms of vitamin A are supplied: preformed vitamin A and its precursor, the potent antioxidant betacarotene. Other immuno-supportive nutrients in LIFE FORCE include vitamin B-6, vitamin C and zinc, which is fundamental for proper functioning of our T-cells, the “seek and destroy” cells of our immune system. LIFE FORCE also now includes 40% more lipoic acid, including the highly bioavailable alpha and R-isomer forms. Lipoic acid along with the B vitamins and CoQ10 promote building the energy reserves needed when the immune system needs to kick into high gear. Powerful Liver Support Your liver is responsible for converting many nutrients into their metabolically active forms before your body can use them. After activation, these nutrients travel through the blood stream to target organs where they perform their metabolic functions. Not only does the liver activate nutrients, but it also plays a crucial role in a variety of other metabolic functions, from fat digestion and cholesterol production to blood sugar regulation to the processing and elimination of toxins, an important role in today’s increasingly polluted world. For all these reasons, nourishing the liver is crucial. And LIFE FORCE does just that. LIFE FORCE contains alpha-lipoic acid, turmeric, silymarin and N-acetyl cysteine (NAC) – all potent antioxidants that support healthy liver function. NAC and alpha-lipoic acid both help produce glutathione, one of the liver’s primary detoxifying molecules. Silymarin, the active flavonoid complex of the herb milk thistle, as well as coenzyme Q10, have been shown in vitro to inhibit lipid peroxidation of cell membranes. Turmeric extract promotes bile flow and is a rich source of the antioxidant, curcumin. LIFE FORCE also contains choline and inositol, vitamin- like molecules which act as lipotropics, unique substances that prevent the deposition of fat in the liver. Since the liver is naturally high in fats, LIFE FORCE is one of the only multiples that contains the fat-soluble form of vitamin C, ascorbyl palmitate, for antioxidant protection. Complete Antioxidant Defense Oxidative stress is the primary cause of accelerated aging. This and other forms of free radical damage are constantly threatening your body. Whether it is from pollution, ultraviolet light, food additives, or from other sources, it is more critical than ever to protect your body with antioxidants. LIFE FORCE contains 24 of the most powerful antioxidants known to science, including eight new antioxidants based on the latest research. It contains antioxidants that are water soluble, such as quercetin and rutin, and ones that are fat soluble, such as alpha-lipoic acid and lycopene. There are antioxidants that are especially protective of specific body systems, such as lutein to protect the macula in your eye, lycopene to protect your prostate gland, and tocotrienols to protect your arteries. Cutting-Edge Vision Nutrition The structure and functions of your eyes are very complex. LIFE FORCE contains nutrients to help support and maintain healthy eye tissue, which is particularly susceptible to oxidative stress from free radicals. To support your healthy macula, aqueous tissue and optical nerve signals, LIFE FORCE includes ingredients such as lutein, astaxanthin, beta carotene, bilberry, zinc, lipoic acid and quercetin. Life Force Replenishes Essential Nutrients to Support Your Low Carb Lifestyle LIFE FORCE contains optimal levels of many nutrients that might be deficient in low carb meals. Counting carbs can lead to restrictions of nutrient-dense foods, such as dairy products, grains, fruits and vegetables. LIFE FORCE contains many of the same protective antioxidants, vitamins and minerals as fruits and vegetables, including betacarotene, vitamin C, vitamin E, flavinols, magnesium and selenium. It also contains high levels of the same vitamins found in grains, including all of the B vitamins, to support your body’s healthy energy metabolism. And it contains nutrients found in dairy products, such as calcium, potassium, vitamin A and vitamin D. Support Healthy Fat and Protein Consumption with Life Force Low carb lifestyles mean higher consumption of proteins and fats. Unfortunately, there are artery, heart, colon and many other health concerns associated with meals that are high in fat and protein and low in fiber and produce. However, the nutrients in LIFE FORCE can help you better process these foods when eating this way. LIFE FORCE contains high levels of protective fat-soluble antioxidants such as alpha lipoic acid, ascorbyl palmitate (vitamin C ester) and vitamin E to protect your body from the free radicals generated by consuming more fats. It also contains many nutrients for liver health, such as silymarin, CoQ10, NAcetyl Cysteine and turmeric to help support the fat metabolism your liver is responsible for. LIFE FORCE also contains a high level of the B vitamin biotin, which aids in fat, protein and energy metabolism. Complete Energizing Nutrition LIFE FORCE is the only multiple to target organ systems with specific nutrients and bio-botanicals, antioxidants and Neuroceuticals® for total body harmony and energy activation, system by system. Only this dedication to going deep to the cellular root of system imbalances can produce a multiple so effective that it is acknowledged in a prestigious scientific review, the Comparative Guide to Nutritional Supplements. A nutritional program with LIFE FORCE at its center can be an easy first step in joining the Wellness Revolution. The goal of this revolution is a long, healthy and fulfilling life. Allow yourself to feel your best, to achieve mental and physical harmony, to radiate energy and vitality. Feel your LIFE FORCE!
References
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=520) CLINICAL APPLICATIONS OF CAPSICUM
Date:
June 23, 2005 11:20 AM
CLINICAL APPLICATIONS OF CAPSICUM Capsicum is a remarkable whole body stimulant that can boost blood flow, tone the nervous system, relieve indigestion, promote sweating, help to cauterize and heal ulcers, ease persistent pain and fight off infection. One very authoritative work on African plants suggests that Capsicum’s “regular ingestion is highly beneficial in hemorrhoids, varicose veins, anorexia, liver congestion and vascular conditions . . .the indigenous inhabitants of Africa and of the Antilles are remarkably free form all of these conditions as they use Capsicum fruit in their diet.”10 Most of the therapeutic actions of Capsicum are attributed to the alkaloid or glucoside content of the herb.11 The latest scientific studies conducted with Capsicum will be discussed in subsequent sections. Herbal Catalyst Because Capsicum boosts peripheral circulation and stimulates organ secretion, it expedites the therapeutic delivery and action of other herbs. In other words, the medicinal benefits of these herbs reach infected or inflamed tissue more rapidly due to enhanced blood flow.12 Consider the following statement: “Cayenne will insure the rapid and even distribution of the active principles of the rest of the herbs to critical function - al centers of the body, including those involved in cellular respiration, metabolism, data transmission, and neural-hormonal activation. Cayenne is included in several other blends for this reason. In extremely small quantities it can dramatically increase the efficiency of most other herbs.”13 Many health practitioners believe that the key to healing is CAPSICUM stimulation. Capsicum stimulates eve rything from blood flow to peristaltic action in the stomach, to intestinal transit time. The re m a rkable ability of Capsicum to stimulate organ secretion and even heart action makes it one of the strongest natural stimulants known. Se veral different kinds of herbal blends targeting various body systems will utilize Capsicum to boost the formula’s efficacy. Cardiovascular Tonic Capsicum is said to be unequaled for its ability to boost circulation and increase heart action. Interestingly, cultures who consume significant amounts of cayenne pepper in their diet have much lower rates of cardiovascular disease.14 Capsicum exerts a variety of desirable actions on the entire card i ovascular system. It has the extraordinary ability to enhance cardiovascular performance while actually lowering blood pressure.15 A quote taken from a card i ovascular publication re a d s , “Capsaicin has also been shown to prolong cardiac action potential in atrial muscle . . .”16 Michael T. Murray, N.D., has stated, “ Cayenne pepper [Capsicum] should be recommended as a food for its beneficial antioxidant and cardiovascular effects.”17 Herbalists have considered Capsicum as a superior “f o o d” for the heart. In fact, in cases where a heart attack is suspected administering capsicum in hot water has been thought to help lessen the severity of the attack. Capsicum can also be placed on or under the tongue in emergencies involving heart attack, stroke or hemorrhaging. 18 Note: Using Capsicum for any heart-related problem, especially a suspected heart attack should never take the place of medical attention or a physician’s care. CAPSICUM Blood Cholesterol Reducer Various studies have conclusively demonstrated that Capsicum reduces the risk of developing atherosclerosis (hardening of the a rteries) by reducing blood cholesterol and triglyceride levels .19 Additional clinical studies conducted in India found that when cayenne was ingested along with dietary cholesterol, the typical rise in liver and blood serum cholesterol levels was significantly inhibited. In addition, bile acids and free cholesterol were subsequently eliminated from the body through the stool.20 Interestingly, these tests revealed that using Capsicum was actually more effective in reducing cholesterol that capsaicin alone.2 1 Daniel Mowrey, Ph.D., emphatically points out that this is just one of many examples of the superiority of whole botanicals as opposed to their isolated components.22 Note: Using Capsicum in combination with Hawthorn is a particularly good cardiovascular tonic. Blood Pressure Equalizer While an added bonus of Capsicum’s capability to lower blood serum cholesterol is a decrease in blood pressure, additional evidence strongly suggests that the herb initiates other mechanisms that fight hypertension .23 “Cayenne, according to another study, also reduces the blood pressure in an even more direct manner: a number of years ago, a team of researchers discove red that capsaicin acts in a reflexive manner to reduce systemic blood pressure, a kind of coronary chemoreflex.”24 Adding Garlic to Capsicum creates an even better therapeutic blend for treating hypertension. Blood Detoxification CAPSICUM “Cayenne is a kind of catalyst in the blood purification process . . . it acts as a diaphoretic, stimulating the excretion of wastes in the swe a t . ”25 Because Capsicum stimulates organ secretion and boosts peripheral blood flow, it would only stand to reason that it would also facilitate the faster removal of toxins from the bloodstream and lymphatic system. You may have already noticed that Capsicum is frequently added to blood-purifying herbal combinations. Circulatory Booster Researchers have found that the simulating action of Capsicum on surface capillaries can help to pre vent cold hands and feet.2 6 For this reason, it may be helpful for Reynaud’s Syndrome. Old remedies using Capsicum have even recommended placing it in socks to warm the feet and to help prevent frostbite. An old folk cure for a chilled body was a steaming hot cup of Capsicum tea. Free Radical Scavenger The rich flavonoid content of Capsicum gives it significant antioxidant capabilities. A recent study conducted in 1995 showed that Capsicum has a higher ascorbic acid content than chiles from the jalapeno or serrano varieties .27 Vitamin C and bioflavonoids can scavenge for dangerous free radicals which cause tissue damage and can predispose organs to degenerative diseases. Free radicals are found everywhere and are created as by-products of metabolic p rocesses including the act of breathing itself. Pollutants can expose the body to free radicals. An interesting study done in Mexico City and published in 1993 found that Capsicum extract was able to modulate the mutagenic activity of urban air samples.28 In other words, these potentially dangerous nitro - a romatic compounds found in polluted air were kept from mutating by red chile extract.29 Chemical breakdowns of Capsicum have also found that CAPSICUM the pepper is high in Provitamin A, which significantly contributes to its healing ability and immune fortification.30 Anti-Carcinogenic Compound Anti-cancer research recently tested Capsicum on laboratory rats and found that it does indeed demonstrate anti-cancer properties by inhibiting certain enzymes which can initiate the mutation of cells.31 What this implies is that taking Capsicum can afford the body some protection against the cellular mutation which occurs in malignant growths. Capsicum actually inhibited the formation of dangerous metabolites under laboratory conditions where they should have normally been activa t e d .3 2 This study implies that Capsicum may have many more sophisticated bio-chemical actions than previously thought. An Impressive Pain Killer Capsaicin has recently emerged as a remarkably effective pain reliever and has become the subject of recent clinical research . Applying capsaicin in cream or ointment form to painful joints, scar tissue or other painful conditions involving peripheral nerves confuses pain transmitters. In other worlds, capsaicin temporarily disrupts sensory nerve cell biochemistry there by impeding the relay of pain sensations from the skin surface. It does this by inhibiting a neurotransmitter called substance P. This specific compound is thought to be the main mediator of pain impulses from peripheral nerve endings.33 Substance P has also demonstrated its ability to inhibit inflammatory pain generated in arthritic joints in much the same way.34 Today, several over-the-counter topical preparations utilize capsaicin for the pain of arthritic joints. The ability of Capsicum to control severe and unresponsive pain is significant, to say the least. Modern clinical utilization of topical capsaicin may offer signifi-cant relief for a number of painful conditions including: diabetic neuropathy, cluster headaches, post-amputation pain, post-mastectomy pain, shingles and painful scar tissue.35 POST-SURGICAL PAIN In the early spring of 1996, prime time national news show s reported that scientists had found that individuals who had suffered from chronic pain in post-surgical scars (heart bypass, arterial grafts, etc.) were successfully treated with topical preparations containing capsaicin. While this may have been news to many of us, clinical studies had been already published for several years that capsaicin held profound value for various kinds of pain which did not respond to established medical treatments. Typically surgical scars and regions around them can produce persistent pain or can be very sensitive to the touch even when completely healed. This type of pain phenomenon seems to respond well to capsaicin ointments and creams. POST-MASTECTOMY PAIN When capsaicin preparations were applied following mastectomy or breast reconstruction, pain was significantly relieved. Se veral double blind studies found that using capsaicin creams four times daily for 4 to 6 weeks resulted in much less frequent occurrence of sharp, jabbing pain.3 6 All thirteen patients studied had a 50 percent or greater improve m e n t .3 7 Various unpleasant sensations other than pain also improved with topical applications of capsaicin creams.38 MOUTH SORES FROM RADIATION OR CHEMOTHERAPY A fascinating study conducted at the Yale Pain Management Center discove red that capsaicin could ve ry significantly lessen pain caused by mouth sores which frequently develop after chemotherapy or radiation.39 Apparently delivering the capsaicin in the form of soft candy (taffy) enabled the substance to be retained in the mouth long enough to desensitize the nerve endings causing the pain. Each one of the eleven case studies re p o rted that their pain had decreased and in two patients, it stopped entirely.40 DIABETIC NEUROPATHY Diabetic neuropathy is a painful nerve condition which can develop in cases of prolonged diabetes. Several double-blind studies have supported the considerable value of capsaicin creams for relieving the pain associated with this disorder.41 The results of a controlled study using Capsicum for seve re cases of diabetic neuropathy which did not respond to conventional therapy were published in 1992. A cream containing Capsicum was applied to painful areas four time a day and pain was carefully e valuated for 8 weeks at two-week intervals. The results we re impressive, to say the least. In the 22 patients who used the Capsicum the following results we re re c o rded: “Capsaicin tre a tment was more beneficial than vehicle treatment in the overall clinical improvement of pain status, as measured by physician’s global evaluation and by a categorical pain severity scale . . . In a follow-up study, approximately 50 percent of the subjects reported improved pain control or were cured . . .”42 No t e : While there was a burning sensation when the Capsicum c ream was first applied, some subjects found that its magnitude and duration lessened with continued application.43 SHINGLES The FDA has approved capsaicin-based ointments for the treatment of pain that results from diseases like shingles. Again, numerous studies have documented the value of capsaicin for decreasing the miserable nerve-related pain associated with shingles. The general consensus derived from these tests were that approximately 50 p e rcent of people suffering from shingles responded well to capsaicin creams, some even after 10 to 12 months.44 Note: If blisters accompany a shingles outbreak, it is better to wait until they have healed before using any capsaicin-based ointments or creams. RELIEF FOR BURNING FEET Frequently an uncomfortable “burning” sensation in the feet will occur in many people, particularly in diabetics. As ironic as it may seem, using capsaicin creams may actually alleviate this burning. “In various studies, diabetics who treated their burning feet with capsaicin got greater improvement and we re able to walk more easily than those not using the cream.”45 In addition, using topical applications of capsaicin as opposed to strong, oral drugs is much more preferable. ARTHRITIS PAIN Clinical tests have confirmed that topical capsaicin ointments substantially alleviate the miserable pain that characterizes osteoand rheumatoid arthritis.46 These studies revealed that using 0.075 capsaicin cream reduced tenderness and pain.47 Dr. Michael T. Murray writes: “ . . . seventy patients with osteoarthritis and thirty - one with rheumatoid arthritis received capsaicin or placebo for 4 weeks. The patients were instructed to apply 0.025 percent capsaicin cream or its placebo to painful knees four times daily. Significantly more relief of pain was reported by the capsaicin-treated patients than by the placebo patients throughout the study . . .”48 Anyone suffering from osteo or rheumatoid arthritis should evaluate the effectiveness of capsaicin ointments for joint pain. Ester Lipstein-Kresch, M.D., has studied the effectiveness of capsaicin creams for arthritis and has stated: “You need to apply it three or four times a day on the affected area for at least two weeks before you’ll see any improvement. An initial burning sensation at the site is not unusual for the first few days, but this goes away with continued application.”49 Note: Capsaicin is also useful for tennis elbow due to its ability to block the transmission of pain. MIGRAINE HEADACHES (CLUSTER TYPE) Topical applications of capsaicin ointments intranasally may also help to relieve the pain of a specific kind of migraine headache called cluster headaches. Cluster headaches are characterized by s e ve re pain which typically radiates around one eye. The term “cluster” refers to the fact that these headaches tend to occur in clusters of one to three per day and can recur at intervals. Headache pain and severity we re reducing in groups using intranasal capsaicin.5 0 This type of capsaicin treatment should be done under a physician’s care. There is some speculation that capsaicin may be more effective in pre venting migraines before they develop into a full blown attack.51
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=405) GPC (GlyceroPhosphoCholine) Versatile Life Support Nutrient ....
Date:
June 21, 2005 05:25 PM
GPC (GlyceroPhosphoCholine): Versatile Life Support Nutrient Parris Kidd, Ph.D.
GPC or GlyceroPhosphoCholine (pronounced gli-sero-fos-fo-ko-lean) is a nutrient with many different roles in human health. It reaches extremely high concentrations within our cells, and its abundance in mother's milk suggests it is crucial to life processes. Clinically, GPC has been most intensively researched for its brain benefits. Biologically, it has great importance for the skeletal "voluntary" muscles, the autonomic nervous system, kidneys, liver, and reproductive organs. GPC goes beyond being a brain nutrient; it is a nutrient for vitality and long life. As a dietary supplement, GPC's brain benefits are unique. It boosts mental performance in healthy young people, as shown by three double-blind trials. In trials on middle aged subjects, GPC improved several physiologic measures of mental performance: reaction time, visual evoked potential, and EEG delta slow waves. In the elderly, GPC improves mental performance and provides noticeable revitalisation. In 11 human trials with 1,799 patients, memory, attention, and other cognitive measures improved. So did mood (including irritability and emotional lability), and patients often developed renewed interest in relatives and friends. GPC was well tolerated, and generated no bad drug interactions. A large trial on elderly subjects with memory challenges published in 2003 concluded GPC had significant benefits for these individuals. GPC Supports Normal Brain Function Circulatory deprivation or surgery can challenge healthy brain function. GPC can speed recovery and support improved quality of life. In four trials with GPC on 2,804 subjects who experienced difficulties under these circumstances, up to 95% showed good or excellent improvement. GPC consistently improved space-time orientation, degree of consciousness, language, motor capacity, and overall quality of life. The investigators concluded GPC offered marked benefits, with an excellent benefit-to-risk profile. Up to half of patients who survive bypass surgery experience problems with memory and other mental performance. A double-blind trial conducted with bypass survivors for six months determined that the GPC group had no remaining memory deterioration, while the placebo group failed to improve. GPC Works Through Multiple Mechanisms GPC supports human health through a variety of mechanisms: 1. It helps keep choline and acetylcholine available to the tissues. Choline is an essential nutrient and GPC appears to be the body's main choline reservoir. GPC in mother's milk represents the baby's main source of dietary choline. Acetylcholine (ACh) is an important substance employed extensively throughout the body. ACh is a major brain transmitter; the motor nerves use ACh to drive the skeletal ("voluntary") muscles; the autonomic nervous system uses it to pace all the organs. ACh is also central to mental and physical endurance, and mind-body coordination. 2. GPC is a major cell-level protectant, not as another antioxidant but in pivotal roles of osmotic pressure regulator and metabolic antitoxin. GPC for osmotic regulation can reach very high concentrations in the kidney, bladder, liver, brain, and other organs. As metabolic protectant, GPC shields proteins against urea buildup. 3. GPC is a major reservoir for cell membrane omega-3 phospholipids. These substances are the major building blocks for cell membranes. Enzymes couple GPC with the omega-3 fatty acid DHA, to make the phospholipid PC-DHA. This makes membranes especially fluid, enabling membrane proteins to perform with better efficiency. GPC produces PC-DHA in the skeletal muscles, wherein fluidity is essential for contraction. Muscles that function abnormally can show GPC deficiency. 4. GPC contributes to both male and female in reproduction. As spermatozoa mature, GPC is used to make PC-DHA that makes their membranes fluid to enable motility. With men, the lower their semen GPC the greater the likelihood of poor sperm motility and with it, infertility. Once semen is inserted into the female, an enzyme in uterine secretions breaks down the semen's GPC into substances that energize the sperm to achieve fertilization. Dosing, Safety, Tolerability, Compatibility Oral intake of GPC in the clinical trials was usually 1,200 milligrams (mg) per day, taken early in the day on an empty stomach. A reasonable dietary supplementation regimen is 1200 mg/day, taken in divided doses (AM and PM) between meals for 15-30 days, and thereafter 600 mg/day for maintenance. Symptomatic subjects can take 1200 mg/day until adequate improvement is achieved. Young, healthy subjects may experience benefit from daily intakes as low as 300 milligrams. GPC is very safe, being compatible with vitamins and nutrients and with pharmaceuticals. In clinical trial comparisons, GPC's benefits surpassed the nutrients acetylcarnitine and CDP-choline. GPC is unmatched for its support of active living and healthy aging. In some 23 clinical trials GPC improved mental performance in all functional categories. GPC can revitalize the aging brain, facilitating growth hormone (GH) release and boosting nerve growth factor actions. GPC's ample presence in human mother's milk suggests it could be conditionally essential. By supporting mental integrity, mind-body integration, the autonomic system, and the body's other organs, GPC enhances the active lifestyle. GPC is remarkable nutritional support for optimal health at any age.
Parris M. Kidd, PhD is a cell biologist trained at the University of California, Berkeley and San Francisco. Since entering the dietary supplement field in 1983, he has published many in-depth reviews of integrative medicine in the journal Alternative Medicine Reviews, and is science columnist for totalhealth magazine. Dr. Kidd is internationally recognized for his accomplishments in dietary supplement product development, documentation and quality control. Disclaimer: the above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=388) The A Team
Date:
June 14, 2005 06:04 PM
The A Team by Gregory Meade Energy Times, October 11, 2004 Want the A Team playing to improve your health? When you accumulate enough antioxidants to help you attack the molecular marauders out to mar your well-being, you improve your chances of avoiding illness. Nowadays you hear plenty of talk about the benefits of antioxidant nutrients. Antioxidants are the ammunition the body uses to fight off internal damage. They offer the body the means to fight against disease but, at the same time, your body must be in the position to use them optimally. That means getting enough sleep, consistently exercising and avoiding overly processed foods. Those lifestyle habits allow your body to garner its resources and effectively implement antioxidants in its quest for well-being. Your body has a love-hate relationship with oxidation: Can't live without it, often has trouble living with it. For instance, the production of energy in your cells requires oxidation. But the byproducts of that process, problematic molecules called free radicals, have to be chemically changed or eliminated to avoid the damage that results when they interact with other parts of the cell. Left unchecked, these molecular troublemakers can wreak havoc, oxidizing and punching holes in cell membranes and damaging other structures they contact. Antioxidant nutrients are used to defend against oxidation, quell these harmful destroyers and limit the potential harm they can cause. For a quick glimpse of one of your basic antioxidant defenses, look in the mirror. The color in your eyes represents antioxidant protection against oxidative injury from the ultraviolet rays in sunlight. Sunlight's energy sets loose free radicals every time it enters the lenses in your eyes. Pigments absorb this radiation and, in most cases, render it harmless. As part of your vision's defenses, two of the antioxidant pigments in your food, lutein and zeaxanthin, are deposited by your body in certain areas of your eyes-in a section called the macula as well as the lens (BJ Opthalmol 1998; 82:907-10). Lutein and zeaxanthin are classified as carotenoids, chemical relatives of beta carotene, the antioxidant pigment that makes carrots orange, and lycopene, the anticancer red coloring found in tomatoes. These fat-soluble nutrients are also present in algae. In both your eyes and plants, these nutrients absorb the destructive ultraviolet rays that give birth to free radicals. Blindness Protection Studies show that consuming large amounts of these pigments lowers your risk of a common form of blindness called age-related macular degeneration (ARMD) and drops your chances of age-related cataracts. (More than 30 million people worldwide suffer from ARMD, and cataracts is the leading cause of blindness across the globe.) When the sun's rays enter the eye, lutein and zeaxanthin absorb and filter out dangerous radiation before it can injure the macula. The macula is the central part of the retina that allows us to see very fine detail. Otherwise, over time, as the macula deteriorates, our vision worsens. In addition, some researchers believe these nutrients help lower your chances of cancer. Lutein and zeaxanthin are found in spinach, Brussels sprouts, corn, collard greens, green beans, egg yolks, broccoli, cabbage, kale, lettuce, kiwi and honeydew melons. The petals of yellow flowers like marigolds and nettles are also rich in these antioxidant nutrients. Broccoli Protection You can also increase your chances of better sight as you age by consuming sulphoraphane, an antioxidant found in broccoli. Researchers at Johns Hopkins University have found that sulphoraphane takes part in the body's efforts to shield eye cells from free radicals generated by ultraviolet light (Proc Natl Acad Sci 2004; 101(28):10446-51). The researchers who performed this study believe that unlike the antioxidant nutrients vitamin C and natural vitamin E, sulphoraphane acts as an "indirect" antioxidant. That means that while those two vitamins are used by the body to directly defuse the harmful oxidative force of free radicals (and then must be replaced or regenerated in the cells), sulphoraphane acts indirectly, boosting the body's immunity defenses. Because of that indirect action, researchers point out, sulphoraphane lasts longer in the body and may produce a more profound, long-term antioxidant effect. In other laboratory tests, researchers have discovered that sulphoraphane can kill Helicobacter pylori, a bacterium recognized 20 years ago as the cause of debilitating stomach ulcers and often-fatal stomach cancers (Proc Natl Acad of Sci 5/28/02). This research shows that sulphoraphane is even effective against antibiotic-resistant Helicobacter. Adding to its benefits, sulphoraphane can help kill bacteria both inside and outside stomach cells; when this bacteria hides inside of cells it is particularly difficult to fight. " We've known for some time that sulforaphane had modest antibiotic activity," says Jed Fahey, a plant physiologist at Hopkins. "However, its potency against Helicobacter, even those strains resistant to conventional antibiotics, was a pleasant surprise." Looking for Mr. Good Diet For the biggest bang for your antioxidant buck, combine antioxidants with good lifestyle habits. A laboratory study of the heart-healthy effects of taking supplements of the antioxidant vitamins C and natural E along with L-arginine (an amino acid) found that exercise magnifies benefits (Proceedings of the National Academy of Sciences 5/24/04, online). The scientists who performed this study recommend exercise along with antioxidants to boost your nutritional advantage. The box score shows that when playing with the A Team you've got the best chance of hitting an antioxidant home run.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=356) Pep Up and Go!
Date:
June 14, 2005 05:45 PM
Pep Up and Go! by Harris Parker Energy Times, February 2, 2000 Feel your energy flagging? You've lost count of the number of phone calls you fielded all afternoon-the last was from your son, who missed the late bus home from school-and colleagues needing your decision are lined up outside your office. Your husband has invited clients home for dinner. You wilt like a new hairdo on a damp August day and pray for a miracle to jump-start your engine. Your pep quotient depends on three essential ingredients: nutrients you consume through your diet and supplements, how much you exercise and your sleep schedule.(Of course, if you're troubled by any kind of disabling, ceaseless fatigue accompanied by mental fuzziness, joint pain, sore throat, swollen glands, headaches and other chronic distress, consult your health practitioner.) Vitamins and Energy Certain nutrients are called vitamins because scientists consider them to be crucial for vitality. They generally function as coenzymes, partnering with the enzymes that are catalysts for the chemical reactions constantly taking place in our bodies. Our need to replenish our store of vitamins, which may merge with cell, muscle, enzyme, hormone, blood and bone structure once they have been absorbed, depends on their rate of utilization, according to The Real Vitamin & Mineral Book (Avery) by Shari Lieberman, PhD, and Nancy Bruning. While a low-fat diet rich in raw fruits and vegetables helps supply important nutrients, a B complex supplement and a balanced multivitamin can guarantee daily vitamin levels. Be Energetic with B Vitamins Vitamins, especially the B vitamins, play extremely important roles in producing cellular energy. The chart on page 39 lists the key vitamins and describes their effects as well as the consequences of not getting enough of them. Their benefit is felt most profoundly in the energy producing process known as the Krebs cycle (which we'll explain in a moment). Vitamins B2 and B3, for example, supply the major building blocks for substances that are called flavin adenine dinucleotide (FAD and FADH) and nicotinamide adenine dinucleotide (NAD and NADH), which are critical elements of energy production in the Krebs cycle as well as a process called oxidative phosphorylation. Hundreds of Reactions Even though you may never have heard of NAD and NADH, these molecules are found in very many places throughout your body; they play a role in hundreds of biochemical reactions in all kinds of cells. B vitamins also combine with other materials to build coenzymes, chemicals which help form other chemicals necessary for cellular energy. B vitamins are crucial: miss out on one or more and you may break these metabolic chains necessary for peak energy. Energy to Spend The main energy currency of every cell single cell is ATP: a chemical called adenosine triphosphate. This material is used by cells for every imaginable task including reproduction, growth, movement and metabolism. Specialized metabolic cycles within the cell are designed to generate ATP. Consequently, the more ATP our cells create, the more energy can be generated. The raw materials used to make cellular energy are glucose (blood sugar) and "free" fatty acids. The best way to supply your cells with the sugar they need is to consume complex carbohydrates which also supply fiber and other nutrients. When you eat carbohydrates, they are made into glucose which is stored as a starch called glycogen in muscles and the liver. Your body can rapidly turn glycogen into glucose for extra energy. (The process of making energy from glycogen yields carbon dioxide and water as well as ATP.) Making Energy The first step in making glucose into energy is called glycolysis. This complicated process requires nine different steps. During these steps, glucose is made into a substance called pyruvate. The process of glycolysis requires ATP, but yields twice as much ATP as is present when it starts. From here, the process gets a little more complicated as pyruvate enters into a complex chain of events in tiny cellular structures called mitochondria. (Many metabolic events take place in the mitochondria.) The pyruvate molecules are converted to a molecule known as acetyl coenzyme A and eventually made into carbon dioxide, water and more ATP. This process is known as the Krebs cycle or citric acid cycle. It also involves a series of events known as oxidative phosphorylation in which NADH formed during the Krebs cycle is oxidized to form ATP. Why is fat such a concentrated source of energy? Free fatty acids enter the Krebs cycle to help generate ATP much more efficiently than glucose - producing roughly six times more energy per gram than glucose. And Don't Overlook. . . . . .other supplements that may aid energy production: • Alpha Lipoic Acid, an antioxidant that works in the fatty tissues of cell membranes and in cells' watery interiors • Coenzyme Q10, also known as ubiquinone as it exists everywhere in the body, acts like a vitamin because it stimulates some reactions. CoQ10 protects cell membranes, especially of the heart, against oxidation and toxins. Ginsengs: Energy Generators With their legendary and slightly mysterious characteristics, the ginsengs are greatly respected natural energy boosters. " Perhaps no herb has excited so much interest in medical circles as ginseng, and yet, strangely, it does not actually 'cure' any one particular ailment," reports Michael Hallowell, the author of Herbal Healing (Avery) and a frequent lecturer on botanic medicine. "Rather, its virtue lies in its tremendous power as a tonic and invigorator. Russian athletes are prescribed large amounts of ginseng because researchers in Moscow have shown that it not only improves stamina, but also increases the efficiency with which blood is pumped to the muscles." What are the physiological mechanisms that allow ginseng to bolster your get up and go? In order to unravel the legend and lore of ginseng, the first step is understanding the intricacies of the three types: • Asian (Panax ginseng), which produces the strongest and most profound stimulation; • American (Panax quinquefolium), which soothes at a more subtle level; • Siberian (Eleutherococcus senticosus), a stamina booster embraced by a wide range of athletes. All three varieties are treasured for their ability to help people adjust to stress. Biologically Active The ginsengs are adaptogens, "biologically active substances found in certain herbs and plants that help the body and mind adapt to the changes and stress of life," says Stephen Fulder, MD, author of The Book of Ginseng and Other Chinese Herbs for Vitality (Inner Traditions). "Stress is not an illness in itself. Stress is change, our ability to adapt to all the changes that occur in life, emotional or physical, from exercise, work, chemicals, drugs, food, radiation, bacteria, disease, temperature, or simply too many late nights or too much fun." The body reacts to stress by producing the hormone adrenaline, which throws the whole body into a state of alert. Metabolism, blood pressure and circulation accelerate; immunity and resistance drastically decline; performance suffers. Top-Notch Tonics Enter the ginsengs, with their varied, subtle tonic qualities. The Greek name for this herb, "panax," means "panacea" or cure-all. But the Chinese, who first referred to it 2,000 years ago, more literally called it "ren shen" or "person root," in reference to its physical resemblance to a miniature human form. " Most exhibit medicinal properties, but each species has a different chemical makeup and has a unique application in Traditional Chinese Medicine (TCM)," says Kim Derek Pritts, author of Ginseng: How to Find, Grow and Use America's Forest Gold (Stackpole). "In general, all true ginseng contains biologically active saponins (chemicals similar to human hormones), essential oils, carbohydrates, sugars, organic acids, nitrogenous substances, amino acids, peptides, vitamins and minerals." Building Vital Energy All the ginsengs strengthen, nourish and build Qi, the TCM concept describing basic vital energy circulating through our bodies. Every physical and mental function, from breathing, thinking, nutrition and circulation, is regulated by Qi. Although many of the Native American tribes used the abundant, indigenous Panax quinquefolium ginseng extensively, particularly to increase mental acuity and boost fertility, the herb never has been as popular in North America as it is in Asia. American ginseng traditionally has been a lucrative export crop to China, where the wild native variety suffers from overharvesting. Even today, according to Paul Bergner in The Healing Power of Ginseng & the Tonic Herbs (Prima), 95% of the American ginseng crop is exported to China, where XiYang Shen, or "western sea root," as it is called, is immensely valued and costs double what it does here. Energy Boost Jacques MoraMarco, author of The Complete Ginseng Handbook: A Practical Guide for Energy, Health and Longevity (Contemporary), as well as a licensed acupuncturist and doctor of Eastern medicine, suggests American ginseng for a slight energy boost. The moderate effect of American ginseng is considered a more appropriate tonic to the intensity of our pace and diet. Variations on a Theme In TCM terms, American ginseng cools and moistens, as well as lubricates and strengthens the body. It is reputed to reduce fevers and night sweats and alleviate hot, dry lung problems like smoker's cough. With its emollient qualities, American ginseng is considered to treat dry, wrinkled skin effectively. The Bolder Energizer Asian ginseng, which includes red Korean panax, is a bolder energizer taken by those who feel depleted from anemia, blood loss, cardiovascular weakness, injury, shock or trauma, as well as the disabling effects of age. In general, Asian ginseng is warming and stimulating, urging the body to run faster. Siberian ginseng, though botanically not a true ginseng, still acts similarly to Asian ginseng in its reputed power to control stress, boost energy, support the immune system, enhance performance and increase longevity. Called Wu Cha Seng in Chinese, Siberian ginseng is perceived by natural practitioners as an ideal herb for the healthy who want to lift both stamina and endurance. Experts believe it counteracts the effects of cortisol, the stress hormone produced by the adrenal glands in response to injury, pain or emotional turmoil. Natural Energy Boosters The herbal pharmacopeia includes several other natural energy boosters available in various forms-shakes and bars for those on the run-loaded with nutrition absent from commercial snacks. Some choices: • Ginkgo biloba-used in Chinese medicine to heat the body and increase sexual energy. Ginkgo enthusiasts take this herb to increase the supply of oxygen to the brain and generally increase circulation. • Gotu kola-may stimulate the central nervous system and help eliminate excess fluid, thereby reducing fatigue. • Astragalus-a Chinese herb that enhances energy and builds the immune system. It is credited with strengthening digestion, improving metabolism, increasing appetite, combating diarrhea and healing sores. • Schisandra-also a Chinese herb, treats respiratory illness, insomnia and irritability and rejuvenates sexual energy. Its mild adaptogens help the body to handle stress. • Licorice-is a favored endocrine toner in Chinese medicine. It is reputed to support the adrenals, the pair of small glands directly above the kidneys that secrete steroidal hormones, norepinephrine and epinephrine, the "fight or flight" hormones. People with high blood pressure or edema, or pregnant women, should avoid it. • Ashwagandha-an Ayurvedic herb used for thousands of years in the traditional healing of India as a potent strength builder for men and women. Experienced herbal practitioners acquire an impressive and fascinating store of knowledge and experience-you'll find it helpful to visit one as you begin your course of ginseng or other energy-boosting herbs. TCM Visitation When you visit a TCM practitioner, you'll notice that she evaluates your body's condition through an extremely careful examination of all the different systems: Several pulse points are felt in order to ferret out and detect troubling abnormalities. The condition and color of the tongue is observed to decipher digestive disorders. In addition, your urine may be examined to determine other imbalances and specific health problems. In many cases, your TCM practitioner will recommend ginseng as an adaptogen that can give you an overall boost. When taking ginseng, follow the directions on the package. Note: in some cases, you may want to consume a little bit less if you suffer headaches, insomnia or high blood pressure. Consult your health practitioner if you are afflicted with either acute inflammatory disease or bronchitis. Then take comfort in the eternal soothing wisdom of Chinese Traditional Medicine. In the first century A.D., the Shen Nong Ben Cao Jing (The Divine Husbandman's Classic of the Materia Medica) effusively described ginseng and the tonic herbs in this beguiling and intriguing manner: "The first class of drugs...are considered to perform the work of sovereigns. They support human life and they resemble heaven. They are not poisonous regardless of the quality and duration of administration."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=353) Cancer at the Millenium - the war on cancer entering its third decade...
Date:
June 13, 2005 10:23 AM
Cancer at the Millenium by Harriet Brown Energy Times, May 1, 1999 With the war on cancer entering its third decade, the necessity grows clearer for medical science to engage the enemy on several fronts. Until recently, high-tech medical weapons like vaccines and gene therapy, inspired by a flood of insights into the molecular basis of cancer, garnered most of the hope, hype, headlines and research money. The science was sexy and the prospect of a "cure" dramatic. But, today, advocates of prevention receive equal, if not greater, attention. Improving our diets and prudently supplementing with vitamins and minerals, can deliver a major preventive impact. Contentious experts concede that at least a third (and probably more) of all cancers can be blamed on a combination of eating too much of the wrong foods and not enough of the right ones. The Dietary Difference Though cancer can progress rapidly once it leaps past its inception, it develops over many years and in several stages. Beneficial compounds in food and supplements may intervene along a line that runs from initial exposure to carcinogens to the final step into outright malignancy. Nutrients may: - counteract environmental poisons and the toxic byproducts of liver metabolism The Big Picture The dietary guidelines advocated by the American Cancer Society and the National Cancer Institute (which generally coincide with those of most health organizations) may sound familiar: Eat plenty of fruits and vegetables. Get lots of fiber. Limit fat, especially animal fat. Go easy on meat and avoid the cured variety (they contain nitrites). If you drink alcohol, do it in moderation. Watch your total calories, and your weight. Pretty straightforward stuff. Carotenoid Characteristics Carotenoids, as their name suggests, are orange and red pigments in fruits and vegetables, most notably carrots and tomatoes, although they're also in everything from sweet potatoes to spinach and brussels sprouts (in the latter their distinctive color is masked by green chlorophyll). Lycopene, a carotenoid found primarily in tomatoes, displays double the free radical-fighting activity of beta carotene, the most widely studied carotenoid. Of 72 studies looking at consumption of tomatoes or tomato-based products reviewed in the February 1999 Journal of the National Cancer Institute, almost half showed a significant reduction in one or more of a variety of cancers. Research shows that lycopene may be best at lowering a man's risk of prostate cancer. A 1995 Harvard Medical School study (Journal of the National Cancer Institute 1995; 87: 1767-76) queried nearly 48,000 male health-care professionals about their consumption of fruits and vegetables. The only foods that reduced their risk of prostate cancer were, apparently, tomato sauce, tomatoes, pizza (tomato paste). For those who ate ten servings a week, risk dropped 45 percent; with four to seven servings, 20 percent. In animal studies lycopene decreased the number and size of mammary tumors (Eleventh International Symposium on Carotenoids, 1996). Tomatoes are one of the richest sources of lycopene. Cooking tomatoes helps by releasing the lycopene from the plant cell walls. Also, the oil in tomato sauce enhances absorption in the stomach. Lycopene is also available in supplements. Unreserved Resveratrol Wine drinkers rejoiced when resveratrol, a constituent of the skin of red grapes, was found to protect their hearts (by blocking oxidation of LDL cholesterol and discouraging blood clotting). Now they have another reason to toast this potent antioxidant. When researcher John Pezzuto at the University of Illinois at Chicago screened about 1,000 plants for anticancer activity, he came up with one whose active ingredient turned out to be resveratrol. In lab tests it squelched both free radicals and inflammation, two well-known cancer inducers (Science, 6/10/97). In a study with mice, resveratrol reduced the number of skin tumors by up to 98 percent compared to control animals. Because the effective doses were high (Pezzuto estimates a person would have to quaff about five gallons of wine a day to get the equivalent) and because more than a drink or two a day may raise the risk of breast cancer, researchers don't recommend nondrinkers take up wine. But supplements of synthesized resveratrol (as well as grape juice) may help. Fat Chance Saturated fat is an authentic dietary villain. Aside from clogging arteries, it's a suspected contributor to several cancers, though the evidence is greater for some cancers (prostate) than for others (breast cancer) Of the two other main categories of fats, monounsaturated and polyunsaturated, mono seems benign, if not positively protective. For example, in a study of the influence of diet on breast cancer, Greek researchers discovered that women who consumed higher amounts of olive oil (which is mostly mono) were less likely to be afflicted with breast cancer (Journal of the National Cancer Institute 1995: 87; 110-116). When it comes to polyunsaturated fats, however, things get complicated. The fat that predominates in corn, sunflower and other vegetable oils, called omega-6, has long been associated with cancer risk in animal experiments. Likewise the type found in margarines, trans fats, which are partially saturated vegetable oils. On the other hand, the omega-3 fats called EPA and DHA, which are found primarily in deep- and cold-water fish like cod, mackerel, and halibut, protect against both heart disease and cancer. In an epidemiological study covering 24 European countries, British researchers established that mortality rates for colon and breast cancers declined as fish and fish oil consumption rose (British Journal of Cancer 1996: 74; 159-64). And Finnish scientists discovered that the breast tissue of women who had breast cancer contained significantly less DHA and EPA than the breasts of healthy women (Nutrition and Cancer 1995: 24; 151-160). Experts believe the omega-3s' anticancer effect derives from its ability to tamp down the prostaglandins that stimulate inflammation. Chronic inflammation unleashes a steady stream of free radicals, which can damage DNA and thereby trigger cancer. Omega-3s also help the liver detoxify potentially harmful substances. Fortunately for the fish-phobic, nonmarine sources of omega-3 fats include flaxseed and hemp oils. Minerals to Lower Cancer Risk n Calcium: possibly protective against colon cancer. In a recent trial (New England Journal of Medicine, 1/14/99) researchers gave people with a history of precancerous colon polyps either two 600 mg calcium tablets a day or a placebo for nine months and found fewer polyps. n Selenium: powerful antioxidant and supporter of immunity. Researchers find that cancer rates in various regions is lowered when soil and vegetables contain more selenium In a selenium-depleted area in China afflicted with one of the highest incidences of stomach and esophageal cancer mortality in the world, scientists asked different groups to take various combinations of nutrients. After five years they found a significant reduction in the cancer rate among those who had gotten supplements of selenium, vitamin E and beta carotene (Biological Trace Element Research 1985; 7: 21-29). In the U.S. researchers studying the potential effectiveness of selenium supplementation for preventing nonmelanoma skin cancers came up with a surprise. The 200 mcg a day the subjects received for an average of 4.5 years had no impact on skin cancer but did significantly cut the rates of lung, colorectal and prostate cancers (Journal of the American Medical Association, 12/25/96). More recently Harvard researchers determined that men with prostate cancer had much lower levels of selenium in their toenails (a measure of consumption) than healthy men (Journal of the National Cancer Institute, 8/119/98). Cruciferous Vegetables Cruciferous vegetables like broccoli, brussels sprouts, cauliflower and kale, have long been singled out for their association with protection against cancer. In a 1996 survey of 94 population studies and clinical trials focusing on consumption of cruciferous vegetables, 67 percent showed a reduced risk, the strongest link being with lung, stomach, colon and rectal cancers (Cancer Epidemiological Biomarkers 1996; 5: 733-748). Scientists at Johns Hopkins showed that sulforaphane, from these plants, stimulates enzymes that help detoxify carcinogens generated in the liver. When they injected rats with a cancer-causing chemical, only 26 percent of the rodents pretreated with sulforaphane developed mammary cancer, compared to 68 percent of controls. Even animals who did come down with cancer had tumors that appeared later and smaller. Other researchers have focused on a cruciferous-vegetable compound called indole-3-carbinol, which has proved especially effective against breast cancer cells. Recently, scientists at the University of California at Berkeley found that indole-3-carbinol, rather than acting as an anti-estrogen, (as had been thought), actually stops breast cancer cells by turning off a protein critical to their replication (Jrnal of Bio Chem, 2/13/98). Consequently, when treating certain forms of cancer, some doctors have paired indole-3-carbinol with the chemotherapy drug tamoxifen - which counteracts estrogen - and found that the combination has proven more potent than either separately. Fiber Several decades ago British physician Denis Burkitt proposed that the low incidence of colon cancer among native peoples in South Africa was attributable to the fact that their diet was rich in fiber. The fiber, it was hypothesized, bulked up the stool, speeding its passage through the bowel and reducing the time carcinogens contact its lining; it also helped neutralize cancer-promoting bile acids. This concept has been backed up by numerous studies. Recently, Harvard researchers sprinkled cold water on this idea, finding that an examination of the eating habits of more than 80,000 female nurses, could find no protective effect against colon cancer or precancerous polyps from consuming fiber (NEJM, January 21, 1999). Most experts' take on this apparent refutation: Maybe the "high fiber" intake in this case wasn't high enough, and this is just one study among many. Fighting Breast Cancer Fiber has also been linked to reduced rates of breast cancer. At first it was thought that if fat was a breast-cancer culprit, fiber might just be a marker for a low-fat diet. But a look at Finland undermined that idea: Finnish women eat both a lot of fat and a lot of fiber, and their breast cancer rate ranks much below that in the U.S., (where we eat gobs of fat and little roughage). Fiber helps take estrogen out of circulation as it passes through the liver, while the isoflavones in many high-fiber plants and vegetables are themselves weak estrogens, which compete for slots on breast tissue's estrogen receptors. The special fiber in flaxseed oil called lignans act against estrogen in two ways: by binding its receptors and by inhibiting the enzyme that converts other hormones into estrogen. Fiber comes in two basic forms, insoluble (e.g., wheat bran, celery, the skins of fruits and vegetables) and soluble (e.g., oat bran, citrus fruits, beans). Until a few years ago, scientists believed that cancer protection came mainly from insoluble fiber, but that thinking has turned around. A soluble fiber called citrus pectin has been shown to halt the tendency of prostate, lung, breast and skin cancers to metastasize, or spread (e.g., Journal of the National Cancer Institute 1995; 87: 3448-353). Typically cancer turns deadly only when it gets into the bloodstream and invades new territory. Modified citrus pectin appears to stop this aggression by preventing cancer cells from attaching to healthy tissue. Novel Antioxidant While the name inositol hexaphosphate (IP6) sounds like a mouthful, many of us consume mouthfuls of this natural substance every day - in foods like corn, rice, whole-grain cereals, oats and wheat. But now scientists have isolated IP-6 and found that this powerful antioxidant can slow the destructive cellular processes that lead to tumors. In a study published in Anti-Cancer Research (Nov/Dec 1998), scientists at the University of Maryland School of Medicine demonstrated that IP-6 could shrink liver tumors in laboratory animals. The researchers believe that IP-6 can help prevent cancer and also be useful in lowering the risk of health problems like kidney stones and heart disease. Research like this continues to expand our knowledge of how to lower the risk of cancer. In the next millennium, with more and more information making its way into the media and onto websites, our power and the responsibility to reduce our risk of cancer will continue to grow and offer new possibilities.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=325) Recognizing the Signs: Roadmap to a Healthy Heart
Date:
June 13, 2005 10:06 AM
Recognizing the Signs: Roadmap to a Healthy Heart by Louis McKinley Energy Times, January 2, 2004 From time immemorial, people have tuned into life's lessons that come from the heart. Sadly, times are changing: If you're like most inhabitants of today's harried world, you may be too distracted to detect important clues about your cardiovascular circumstances. And while heart lessons may be more complicated than simply connecting the physiological dots, understanding those heart messages are imperative for improving and maintaining your heart health. Every cell in your body relies on heart-powered blood flow to keep it supplied with nutrients, oxygen, hormones and other natural chemicals necessary for survival. Without that supply of life-giving substances, few cells in the body-including those within the heart itself-can survive very long. And just as damage to a major roadway can cause mayhem with traffic patterns, damage to blood vessels and the heart can wreak a lumpy cardiovascular havoc that blocks the passage of blood and endangers your heart's well-being. Your Heart Disease Chances Within the last ten years, scientific research performed by investigators around the world has focused on the specific factors that most strongly influence your chances of developing heart disease and suffering either a heart attack or a stroke. While much of your risk depends on your genetic inheritance and family history, several factors that determine your heart health are within your control. The most important factors you can do something about include: * Smoking: free radicals generated by burning tobacco causes significant damage to blood vessels and other cells * Lack of exercise: the human body is designed for consistent, moderate physical activity; without exercise, the body slacks off in creating antioxidant protection for arteries * Diabetes: when excess blood sugar persists, physiological processes begin that endanger the heart and arteries * Cholesterol: when oxidized (a chemical process that has been compared to a kind of internal rusting), cholesterol can form artery-blocking plaque; antioxidant nutrients like vitamin C and natural vitamin E may help the body limit this process * High blood pressure: excessive pressure within the blood vessels raises the risk of damage to the heart and arteries; a program of weight loss and exercise can help control blood pressure * Being overweight: the extra body fat carried around your middle is linked to a greater risk of heart problems Heart Attack Signs Do you think you know what a heart attack feels like? Well, if you think it feels like a dramatic pain somewhere in your chest that knocks you to the floor, you're probably wrong. "Most heart attacks do not look at all like what one of my colleagues calls the 'Hollywood' attack-the heart attack you see on television or in the movies," warns Julie Zerwic, MD, professor of surgical nursing who has studied what happens when people develop heart disease and suffer damage to their hearts. "The symptoms [of heart problems] are not necessarily dramatic. People don't fall down on the floor. They don't always experience a knife-like, very sharp pain. In fact, many people describe the sensation as heaviness and tightness in the chest rather than pain," she says. And, if you're a woman experiencing a heart attack, you may not even feel discomfort specifically in your chest. Instead you may experience a severe shortness of breath. The apparent ambiguity of the discomforts caused by a heart attack lead many people to either ignore them or take hours to realize they need to go to the emergency room at the hospital. Consequently, much fewer than half of all individuals undergoing a heart attack actually go to a hospital within an hour of the start of the attack. That delay can be a fatal mistake. "Timing is absolutely critical," laments Dr. Zerwic. "If treatment starts within a hour after the onset of symptoms, drugs that reestablish blood flow through the blocked coronary artery can reduce mortality by as much as 50%. That number drops to 23% if treatment begins three hours later. The goal is to introduce therapy within two hours." However, in Dr. Zerwic's research, only 35% of non-Hispanic whites go to the hospital within an hour of the start of a heart attack. And among African-Americans, the number of people going to the hospital right away drops to a frighteningly low 13%. Often, people will lie down or use a heating pad to relieve the tightness they feel in the chest," says Dr. Zerwic. "They may take some medicine and wait to see if that works. All these steps postpone needed treatment." Signs of a possible heart attack include: * Chest discomfort: Heart attacks most frequently cause discomfort in the center of the chest that can either go away after a couple of minutes (and come back) or persist. The discomfort may feel like strong pressure, fullness or pain. * Upper body discomfort: An attack may set off pain or discomfort in either or both arms, and/or the back, neck, jaw or stomach. * Shortness of breath: Chest discomfort is frequently accompanied by shortness of breath. But it's important to note that shortness of breath can take place even in the absence of chest discomfort. * Other signs: You can also break out in a cold sweat, or feel nauseated or light-headed. A Woman's Sleep Signs If you are a woman who suddenly experiences a marked increase in insomnia and puzzling, intense fatigue, you may be in danger of an imminent heart attack. In an attempt to understand how women's symptoms of heart problems differ from those of men, researchers talked to more than 500 women in Arkansas, North Carolina and Ohio who had suffered heart attacks. (Technically, what they had experienced is referred to as acute myocardial infarction.) They found that chest pain prior to a heart attack was only reported by about 30% of the women surveyed. More common were unusual fatigue, sleep disturbances and shortness of breath (Circulation Rapid Access, 11/3/01). "Since women reported experiencing early warning signs more than a month prior to the heart attack, this [fatigue and sleep problems] could allow time to treat these symptoms and to possibly delay or prevent the heart attack," says researcher Jean C. McSweeney, PhD, RN, nursing professor at the University of Arkansas for Medical Sciences in Little Rock. In Dr. McSweeney's study, more than nine out of ten women who had heart attacks reported that they had had new, disturbing physical problems more than a month before they had infarctions. Almost three in four suffered from unusual fatigue, about half had sleep disturbances, while two in five found themselves short of breath. Other common signs included indigestion and anxiety. "Women need to be educated that the appearance of new symptoms may be associated with heart disease and that they need to seek medical care to determine the cause of the symptoms, especially if they have known cardiovascular risks such as smoking, high blood pressure, high cholesterol, diabetes, overweight or a family history of heart diseases," says Dr. McSweeney. Dr. McSweeney warns that, until now, little has been known about signs that women are having heart trouble or heart attacks. The fact that most of Western medicine's past attention has been on heart problems in men has obscured the warning signs in women. As part of Dr. McSweeney's studies, she and her fellow researchers have discovered that more than 40% of all women who suffer a heart attack never feel any chest discomfort before or during the attack. "Lack of significant chest pain may be a major reason why women have more unrecognized heart attacks than men or are mistakenly diagnosed and discharged from emergency departments," she notes. "Many clinicians still consider chest pain as the primary symptom of a heart attack." Vitamins for Diabetes and Heart Disease Having diabetes significantly raises your chance of heart disease, which means that keeping your blood sugar levels under control can reduce your chances of suffering a heart attack. Today, 17 million Americans have diabetes and, as the country's population in general gains weight and fails to exercise, the number of people suffering this problem continues to grow. The first line of defense against diabetes consists of exercise and weight control. All you have to do is take a brisk walk for 30 minutes a day to drop your chances of diabetes (American Journal of Epidemiology 10/1/03). "We have found that men and women who incorporate activity into their lifestyles are less likely to develop type 2 diabetes than those who are sedentary. This finding holds no matter what their initial weight," said Andrea Kriska, PhD, professor of epidemiology at University of Pittsburgh Graduate School of Public Health. To help your body fight the development of diabetes, researchers also recommend vitamin C and natural vitamin E. Researchers working with lab animals at the University of California at Irvine have found that these antioxidant vitamins can help insulin (the hormone-like substance secreted by the pancreas) reduce harmful blood sugar. In addition, these vitamins shrink the chances of organ damage that can be caused by diabetes (Kidney International 1/03). In this investigation, these vitamins also helped reduce blood pressure, another risk factor that raises heart disease risk. "Blood pressure was lowered to normal, and free radicals were not in sufficient numbers to degrade the sugars, proteins and nitric oxide," notes Nick Vaziri, MD, professor of medicine at the University of California. "We think this shows that a diet rich in antioxidants may help diabetics prevent the devastating cardiovascular, kidney, neurological and other damage that are common complications of diabetes." Free Radical Blues Dr. Vaziri and his group of researchers found that untreated diabetes raised blood pressure and increased the production of free radicals, caustic molecules that can damage arteries and the heart. Free radicals can change blood sugar and other proteins into harmful substances, boosting tissue and heart destruction. In Dr. Vaziri's work with lab animals, he found that treating diabetes with insulin lowered blood pressure and helped keep sugar and protein from changing into dangerous chemicals, but allowed the free radicals to subvert nitric oxide, a chemical the body uses to protect itself from free radicals. In this investigation, adding vitamins C and E to insulin insulated the body's sugars, proteins and nitric oxide from oxidative assault. This produces a double advantage: Lowering the risk of heart disease and other damage to the body from diabetes. Maitake, an Oriental mushroom that has been shown to have many health benefits, can also be useful for people with diabetes who are trying to avoid cardiovascular complications. Laboratory studies in Japan demonstrate that maitake may help lower blood pressure while reducing cholesterol (Biological & Pharmaceutical Bulletin 1997; 20(7):781-5). In producing these effects, the mushroom may also help the body reduce blood sugar levels and decrease the risk of tissue damage. No Smoking! Tobacco smoke is one of the most notorious causes of heart problems. In the same way a hard frost exerts a death grip on a highway, the smoke from cigarettes can freeze up arteries and hamper their proper function. A healthy artery must stay flexible to comfortably allow adequate circulation. But "...when blood vessels are exposed to cigarette smoke it causes the vessels to behave like a rigid pipe rather than a flexible tube, thus the vessels can't dilate in response to increased blood flow," says David J. Bouchier-Hayes, MD, professor of surgery at the Royal College of Surgeons in Ireland, who has studied the deleterious effects of tobacco. This rigidity is called endothelial dysfunction. When arteries are rigid, blockages gum up vessels, clots and other impediments to blood flow appear, and your risk of heart attack and stroke increases (Circulation 2001 Nov 27; 104(22):2673). This condition can also cause chest pain (angina) similar to that caused by a heart attack, and should be evaluated by a knowledgeable health practitioner. Although all experts recommend you stop smoking to lower your heart disease risk, some studies have found that Pycnogenol(r), a pine bark extract that helps the body fight inflammation, may ease some of smoking's ill effects. In a study of platelets, special cells in the blood that can form dangerous blood clots, researchers found that Pycnogenol(r) discouraged platelets from sticking together (American Society for Biochemical and Molecular Biology 5/19/98). By keeping platelets flowing freely, this supplement may alleviate some of the heart-threatening clots that tobacco smoke can cause. In Ayurvedic medicine, a traditional therapy from India, an herb called guggul has also been used to lower the risk of blockages in arteries. This herb, derived from the resin of the mukul tree, has been shown to reduce cholesterol by about 25%. People taking this herb have also reduced their triglycerides (harmful blood fats) by the same amount (Journal Postgraduate Medicine 1991 37(3):132). The Female Version of Heart Disease
For one thing, women often don't suffer from the crushing chest pain that for most people characterizes a heart attack; instead, many women experience back pain, sweating, extreme fatigue, lightheadedness, anxiety or indigestion, signs that can be easily misread as digestive troubles, menopausal symptoms or indicators of aging. The genders also differ in how heart disease poses a threat. While men seem most endangered by the buildup of blockages in arteries, women apparently are more at risk from endothelial dysfunction. But more study needs to be done since, in many cases, researchers have been unable to pin down the precise mechanism that causes many women to die of heart disease. Scientists have found that the number of women in their 30s and 40s who are dying from sudden cardiac arrest is growing much faster than the number of men of the same age who die of this cause. But research by the Oregon Health & Sciences University and Jesse E. Edwards Cardiovascular Registry in St. Paul, Minnesota, shows that while doctors can pinpoint the coronary blockages that kill men, they can't find specific blockages in half of the female fatalities they have studied (American Heart Journal 10/03). "This was an unexpected finding. However, the study underscores the need to focus on what is causing these younger women to die unexpectedly because the number of deaths continues to increase," says Sumeet Chugh, MD, a medical professor at Oregon. Since the failure of arteries to relax probably contributes to heart disease in many women, eating red berries, or consuming supplements from berries such as chokeberry, bilberry or elderberry, may be important in lowering women's heart disease risk. These fruits help arteries expand and allow blood to flow freely. Red berries are rich sources of flavonoids, polyphenols and anthocynanins. The anthocyanins are strong antioxidants that give the berries their color. Research at the Indiana University School of Medicine have found that these chemicals can interact with nitrous oxide, a chemical produced by the body, to relax blood vessels (Experimental Biology conference 5/20/02). Working Out As researchers work to devise lifestyle roadmaps that can steer you around the perils of heart disease, they are finding that exercise is a key path to avoiding cardiovascular complications. A 17-year study of about 10,000 Americans found that those who exercised and kept their weight down (or took weight off and kept it off) experienced a significantly lower risk of heart problems (Preventive Medicine 11/03). "The fact is that those who both exercised more and ate more nevertheless had low cardiovascular mortality," says Jing Fang, MD, of the Albert Einstein College of Medicine in the Bronx, New York. Burning calories in physical activity may be the secret to reducing heart disease risk and living longer, she says. Dr. Fang's research used information collected from the First National Health and Nutrition Examination Survey in 1975 and then computed how much people exercised, how their body mass indices varied and which of these folks died of heart disease during the next two decades. In the study, more than 1,500 people died of heart disease. Those who worked out and consumed more calories cut their risk of heart disease death in half. Exercise Is Essential "Subjects with the lowest caloric intake, least physical activity, and who were overweight or obese had significantly higher cardiovascular mortality rates than those with high caloric intake, most physical activity, and normal weight," Dr. Fang notes. The individuals in the study who were overweight and didn't exercise had a bigger risk of heart disease even if they tried (and succeeded) at eating less. "This suggests that heart disease outcome was not determined by a single factor, but rather by a compound of behavioral, socioeconomic, genetic and clinical characteristics," according to Dr. Fang. According to researchers, if your job requires a great deal of physical activity, your health will be better if you get another job. Exercise on the job not only doesn't decrease your risk of heart disease, it may actually raise it. The reason: On-the-job activity is linked to heart-endangering increases in job stress. Research into this subject, performed at the Keck School of Medicine of the University of Southern California, found that while recreational exercise slowed hardening of the arteries, workers who had to exert themselves during the workday had arteries that were blocked at a younger age (American Journal of Medicine 7/03). In this study, researchers examined about 500 middle-aged employees as part of what is called the Los Angeles Atherosclerosis Study. "We found that atherosclerosis progressed significantly faster in people with greater stress, and people who were under more stress also were the ones who exercised more in their jobs," says James Dwyer, PhD, professor of preventive medicine at the Keck School. According to Dr. Dwyer, "This suggests that the apparent harmful effect of physical activity at work on atherosclerosis-and heart disease risk-may be due to the tendency of high-activity jobs to be more stressful in modern workplaces. "It appears from our findings that the psychological stresses associated with physically active jobs overcomes any biological benefit of the activity itself." Playful Workouts On the other hand, the scientists found that heart disease drops dramatically among those who exercise the most in their spare time. In the study, people who vigorously worked out at least three times a week had the lowest risk. But even those who just took walks enjoyed better heart health than people whose most strenuous activity was working the TV remote. Dr. Dwyer says, "These results are important because they demonstrate the very substantial and almost immediate-within one or two years-cardiovascular benefit of greater physical activity." Lowering your risk of heart disease is substantially up to you. Listen to what your heart tells you it needs; then, exercise your right to fetch some cardiovascular necessities.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=321) Down with Blood Pressure
Date:
June 12, 2005 08:03 AM
Down with Blood Pressure by Kim Erickson Energy Times, January 6, 2002 More than one of four Americans suffers from high blood pressure, also known as hypertension. This so-called silent killer is often the first step in developing long-term problems like heart disease and stroke. According to the American Heart Association, high blood pressure leads to about 45,000 deaths a year and contributes to another 210,000. Hypertension is more common in women beginning at age 50, particularly African-American women. And since high blood pressure rarely causes obvious physical distress, unless your health practitioner monitors your blood pressure on a regular basis, it's easy to miss. The famous study by the National Heart, Lung and Blood Institute (NHLBI), known as the Framingham Heart Study, found that half of all people who suffered a first heart attack and two-thirds of first-time stroke victims also had moderate to high blood pressure. What's more, left untreated, high blood pressure can also increase the risk of atherosclerosis (hardening of the arteries), aneurysms, loss of vision and kidney failure. Normal blood pressure is considered 120/80. When blood pressure reaches 140/90 or above on a consistent basis, you have high blood pressure. What do the numbers mean? The top number, systolic pressure, represents the peak pressure generated in your arteries when your heart beats. The bottom number, diastolic pressure, indicates the pressure when your heart is at rest between heartbeats. Among 95% of all people with high blood pressure, health practitioners can generally pinpoint no specific, single cause. So Salty For decades, the most common recommendation for people with high blood pressure was to eat less salt. Experts have advocated reducing our salt intake to no more than three teaspoons a day: six grams (2400 mg), which is four grams less than the current national average. This recommendation was largely based on a study conducted by Northwestern University Medical School in Chicago, Illinois, known as INTERSALT. The study tested more than 10,000 men and women from 32 countries. The researchers concluded that eating a lot of salt was linked to rises in blood pressure. Other scientists haven't always found the same results. One review of 56 clinical trials by the Integrative and Behavioral Cardiology Program at the Mount Sinai School of Medicine in New York found only a modest reduction in blood pressure when the salt shaker was left unshaken. And an analysis of 58 studies by academics at the University of Copenhagen, Denmark found that, overall, studies did not support a general recommendation to reduce the amount of salt we consume. Added to all this confusion, many people are salt sensitive: their bodies retain excess salt instead of flushing it out of their systems. Unfortunately, only medical tests can reveal this sensitivity. Consequently, experts still recommend that you eat fewer foods containing salt. That means going easy on processed foods, lunch meats and soft drinks. In addition, increasing your intake of potassium, calcium and magnesium may help your blood pressure. Mitigating Minerals Foods rich in potassium and magnesium not only help regulate blood pressure, but may boost overall cardiovascular health and reduce the risk of stroke. Vegetarian items such as bananas, baked potatoes and oranges are rich in these minerals. Research that looked at 30,000 doctors found that those who ate diets rich in fiber, potassium and magnesium had lower blood pressure than the men who ate few of these mineral-rich foods (Circ, 1992; vol 86:1475-1484). A study of 40,000 female nurses found that their pressure decreased when they consumed fibrous and magnesium-filled foods (Hypertension, 1996, vol 27:1065-1072). CoQ10 The nutrient CoQ10 is a vitamin-like substance which acts as an antioxidant in the body, decreasing the harm caused by caustic substances known as free radicals. Found in every part of the body, CoQ10 is necessary for producing energy in every cell. But it is estimated that nearly 40% of people with high blood pressure are deficient in CoQ10. Tests of CoQ10 seem to show that it can often reduce blood pressure by almost 10% (Cur Ther Res 1990;47: 841-845). It also appears to reduce blood triglycerides, blood fats linked to heart disease, and insulin, while slightly increasing HDL (good) cholesterol. Food Fight Perhaps the biggest breakthrough in lowering blood pressure without the use of prescription medicine came with a study known as DASH (Dietary Approaches to Stop Hypertension). Funded by NHLBI and the National Institutes of Health, the multicenter study examined more than 400 people with high blood pressure. These folks were divided into three groups. One ate the standard high-sodium, high-fat American diet, the second a diet high in fruits and vegetables, and the third a combination diet rich in fruits, vegetables and low-fat dairy products (the DASH diet). While the group eating plenty of fruits and vegetables enjoyed a modest reduction in blood pressure, the study found that combining low-fat dairy with produce lowered both systolic and diastolic blood pressure by 11.4 and 5.5 points, respectively. And the benefits came quickly. Many of the people on the combination diet lowered their blood pressure within two weeks. The results were so impressive that researchers at Brigham and Women's Hospital in Boston, Massachusetts suggested that the DASH diet may offer an alternative to drug therapy for people with hypertension and may even serve to prevent high blood pressure altogether. The DASH diet is low in saturated fat and rich in whole grains, fruits and vegetables. Similar to the diet found in Mediterranean cultures, DASH also includes nuts, seeds and legumes, and is supplemented by non- or low-fat dairy products. Moderate amounts of protein-in the form of fish, poultry and soy-are also eaten. Eating in the DASH may also spur weight loss. Since being overweight can increase your blood pressure, the NHLBI strongly recommends a low-calorie diet such as DASH to take off extra pounds. Exercise and stress relief play critical roles in most pressure-reducing plans. Working out not only helps shed weight, it can also lower your blood pressure. Low to moderate aerobic exercise four days a week may lower blood pressure just as effectively as a higher intensity workout. And learning how to manage stress has helped dropped pressures in people with hypertension (Arch Intern Med 2001; 161:1071-80). Nutrition and lifestyle: two vital relief valves for dropping your high blood pressure and increasing your chances of longer life.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=300) Energy Vitamins
Date:
June 11, 2005 05:50 PM
Energy Vitamins by Daniel Mowrey, PhD Energy Times, June 7, 1998 Do you suffer groggy mornings clouded with tired and achy feelings? Do you have to struggle to muster sufficient energy to cope with the day? Then, throughout the morning and afternoon, does frequent fatigue, weakness or depression persist on your horizon like an ugly storm cloud? And your evening may bring little relief as you slump into bed for a restless night, only to begin the same routine the next morning. If lack of vim and vigor plagues your days and nights, your body may be suffering from an inability to synthesize sufficient energy. Our lives depend on processing the food we eat into substances our cells can take in and use. In a never-ending cycle, our body breaks food down and reconstructs the components to form body structures and burn as energy. How much you exercise, the food and supplements you eat and how much you sleep influence the efficiency of these processes. Vitamins and Energy Certain nutrients are called vitamins because they are crucial for vitality. These nutrients are essential to a productive life, the starting point for all life-giving and life-sustaining processes. Because of vitamins' crucial role in energy production, many people can perk up their stamina simply by consuming an adequate supply of vitamins in their daily diet. Since many vitamins - especially the ones concerned with energy - must be constantly replenished, a decent diet and the right supplements must be consumed every day. Be Energetic with B Vitamins Vitamins, especially the B vitamins, play extremely important roles in producing cellular energy. Their most important roles are shown in the illustration on page 48. The chart on page 46 lists the key vitamins and describes their effects as well as the consequences of not getting enough of them. Their effect is felt most profoundly in the energy producing process known as the Krebs cycle (which we'll explain in a moment). Vitamins B2 and B3, for example, supply the major building blocks for substances called flavin adenine dinucleotide (FAD and FADH) and nicotinamide adenine dinucleotide (NAD and NADH) which are critical elements of producing energy in the Krebs cycle as well as a process called oxidative phosphorylation. Even though you may never have heard of NAD and NADH, these molecules are found in many places in your body; they play a role in hundreds of biochemical reactions in all kinds of cells. B vitamins also combine with other materials to build coenzymes, chemicals which help form other chemicals necessary for cellular energy. B vitamins are crucial: miss out on one or more and you may break these metabolic chains necessary for peak energy. Energy to Spend The main energy currency of every cell is ATP: adenosine triphosphate. This material is used by cells for every imaginable task including reproduction, growth, movement and metabolism. Specialized metabolic cycles within the cell are designed to generate ATP. Consequently, the more ATP our cells create, the more energy can be generated. The raw materials used to make cellular energy are glucose (blood sugar) and "free" fatty acids. The best way to supply your cells with the sugar they need is to consume complex carbohydrates which also supply fiber and other nutrients. When you eat carbohydrates, they are made into glucose which is stored as a starch called glycogen in muscles and the liver. Your body can rapidly turn glycogen into glucose for extra energy (The process of making energy from glycogen yields carbon dioxide and water as well as ATP.) Making Energy The first step in making glucose into energy is called glycolysis. This complicated process requires nine different steps. During these steps, glucose is made into a substance called pyruvate. The process of glycolysis requires ATP, but yields twice as much ATP as is present when it starts. From here, the process gets a little more complicated as pyruvate enters into a complex chain of events in tiny cellular structures called mitochondria. (Many metabolic events take place in the mitochondria.) The pyruvate molecules are converted to a molecule known as acetyl coenzyme A and eventually made into carbon dioxide, water and more ATP. This process is known as the Krebs cycle or citric acid cycle. It also involves a series of events known as oxidative phosphorylation in which NADH formed during the Krebs cycle is oxidized to form ATP. Why is fat such a concentrated source of energy? Free fatty acids enter the Krebs cycle to help generate ATP much more efficiently than glucose - producing roughly six times more energy per gram than glucose. Get Your Vitamins Every Day While we rely on our diet to supply many of our vitamins, a B complex supplement and multi-vitamins can ensure you consume sufficient amounts of these crucial nutrients. Many experts agree that a diet rich in raw fruits, nuts and vegetables that minimizes saturated fat can supply adequate a-mounts of these nutrients. Other supplements that may aid energy production: Alpha Lipoic Acid, an antioxidant that works in the fatty tissues of cell membranes and in cells' watery interiors. CoQ10, a nutrient that protects cell membranes, especially of the heart, against oxidation and toxins. Plus, herbs such as suma, ginseng and licorice root as well as creatine, carnitine and pyruvate. Of course if you suffer from any long term, intractable fatigue, consult your health practitioner. But for most cases of decreased vim and vigor, adequate vitamins should help your body recover your get up and go.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=299)
Date:
June 09, 2005 05:36 PM
Energy Vitamins by Daniel Mowrey, PhD Energy Times, June 7, 1998 Do you suffer groggy mornings clouded with tired and achy feelings? Do you have to struggle to muster sufficient energy to cope with the day? Then, throughout the morning and afternoon, does frequent fatigue, weakness or depression persist on your horizon like an ugly storm cloud? And your evening may bring little relief as you slump into bed for a restless night, only to begin the same routine the next morning. If lack of vim and vigor plagues your days and nights, your body may be suffering from an inability to synthesize sufficient energy. Our lives depend on processing the food we eat into substances our cells can take in and use. In a never-ending cycle, our body breaks food down and reconstructs the components to form body structures and burn as energy. How much you exercise, the food and supplements you eat and how much you sleep influence the efficiency of these processes.
Vitamins and Energy
Be Energetic with B Vitamins Vitamins B2 and B3, for example, supply the major building blocks for substances called flavin adenine dinucleotide (FAD and FADH) and nicotinamide adenine dinucleotide (NAD and NADH) which are critical elements of producing energy in the Krebs cycle as well as a process called oxidative phosphorylation. Even though you may never have heard of NAD and NADH, these molecules are found in many places in your body; they play a role in hundreds of biochemical reactions in all kinds of cells. B vitamins also combine with other materials to build coenzymes, chemicals which help form other chemicals necessary for cellular energy. B vitamins are crucial: miss out on one or more and you may break these metabolic chains necessary for peak energy.
Energy to Spend Consequently, the more ATP our cells create, the more energy can be generated. The raw materials used to make cellular energy are glucose (blood sugar) and "free" fatty acids. The best way to supply your cells with the sugar they need is to consume complex carbohydrates which also supply fiber and other nutrients. When you eat carbohydrates, they are made into glucose which is stored as a starch called glycogen in muscles and the liver. Your body can rapidly turn glycogen into glucose for extra energy (The process of making energy from glycogen yields carbon dioxide and water as well as ATP.)
Making Energy From here, the process gets a little more complicated as pyruvate enters into a complex chain of events in tiny cellular structures called mitochondria. (Many metabolic events take place in the mitochondria.) The pyruvate molecules are converted to a molecule known as acetyl coenzyme A and eventually made into carbon dioxide, water and more ATP. This process is known as the Krebs cycle or citric acid cycle. It also involves a series of events known as oxidative phosphorylation in which NADH formed during the Krebs cycle is oxidized to form ATP. Why is fat such a concentrated source of energy? Free fatty acids enter the Krebs cycle to help generate ATP much more efficiently than glucose - producing roughly six times more energy per gram than glucose. Get Your Vitamins Every Day While we rely on our diet to supply many of our vitamins, a B complex supplement and multi-vitamins can ensure you consume sufficient amounts of these crucial nutrients. Many experts agree that a diet rich in raw fruits, nuts and vegetables that minimizes saturated fat can supply adequate a-mounts of these nutrients. Other supplements that may aid energy production: Alpha Lipoic Acid, an antioxidant that works in the fatty tissues of cell membranes and in cells' watery interiors. CoQ10, a nutrient that protects cell membranes, especially of the heart, against oxidation and toxins. Plus, herbs such as suma, ginseng and licorice root as well as creatine, carnitine and pyruvate. Of course if you suffer from any long term, intractable fatigue, consult your health practitioner. But for most cases of decreased vim and vigor, adequate vitamins should help your body recover your get up and go.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=260) VITAMIN A and CAROTENOIDS - What are they good for?
Date:
June 09, 2005 09:27 AM
In 1912, Casimir Funk coined the term 'vitamine' to refer to a 'vital factor' he proposed was an essential component present in foods. His conjecture dovetailed with other research, leading to the isolation in the 1930's and 40's of the compounds we now call vitamins. Vitamins are chemical substances which play a variety of roles in the human body. They are core components of any nutritional supplementation program. While many people are aware of vitamins as necessary substances for good nutrition, few have a grasp of the extraordinary complexity of the roles they play in our bodies. As you'll see below, vitamins are involved in trillions of biochemical interactions every minute to keep us alive and functioning. For example, B-vitamins are converted into coenzymes which are directly necessary for the production of ATP energy from food, a process that goes on continuously in every cell in the body and which in turn fuels myriad physiological events such as muscle contraction, brain activity or tissue repair. Source Naturals offers a full line of vitamins in bioactive forms, allowing you to tailor a nutritional supplementation plan to your individual needs.
VITAMIN A and CAROTENOIDS Vitamin A Vitamin A is a generic term for a class of fat-soluble substances called retinoids, which can either be consumed preformed or synthesized by the liver from plant pigments called carotenoids (see 'Carotenoids', below). An essential nutrient, vitamin A is perhaps best known for its role in vision. The outer segments of the rods, a type of light-sensitive cell in the retina of the eye, contain a pigment called rhodopsin (or 'visual purple') that mediates vision in dim light. Cone cells mediate color vision via three additional pigments. Both rods and cones are surrounded by pigmented epithelial cells that store vitamin A. Rhodopsin is formed from a protein called opsin and a vitamin A-dependent compound called 11-cis retinal. As light strikes the rods and cones it is absorbed by the pigment molecules, and retinal is split off from opsin. This chemical change allows an electrical impulse to be sent to the optic nerve and thus to the brain. The pigment must then be regenerated from opsin and retinal. Repeated small losses of retinal during this process require a constant replenishment of vitamin A to the eyes. Vitamin A also plays an extremely important role in epithelial cell differentiation. Cell differentiation is the process by which a cell undergoes a change to a specialized cell type, allowing it to perform particular functions in the body. It is not yet understood precisely how vitamin A is involved in this process. One hypothesis is that it directly affects gene expression through its interaction with chromatin, a complex of DNA, RNA and protein in the cell nucleus. These interactions affect the process of transcription of DNA to messenger RNA, leading to synthesis of a specific group of cellular proteins. Each one of us carries in our DNA a unique genetic blueprint. This genetic material is the same in every cell of our bodies. It is only because of this mysterious and magical process of differentiation that we have specialized cell types - and therefore eyes, ears, lungs and hearts. Vitamin A is necessary, either directly or indirectly, for the healthy growth and functioning of many of our tissues and organ systems, including the eyes, the skin, the bones, the reproductive system, and the natural defenses. It is not yet known whether this requirement is due to the role of vitamin A in cell differentiation or whether there are other physiological processes for which vitamin A is essential. Carotenoids Vitamin A is related to a class of nutrients called carotenoids, including alpha and beta carotene, lycopene and lutein. Carotenoids are botanical pigments whose colors range from red to orange to yellow. Some carotenoids, particularly beta carotene, can be converted into vitamin A predominantly in the intestinal mucosa and to some extent in the liver. Carotenoids are completely non-toxic; their conversion into vitamin A is well-regulated by the body, making them extremely safe sources of this essential nutrient. In addition to their role as safe sources of vitamin A, carotenoids are powerful nutrients in their own right. Their primary claim to fame is their powerful antioxidant action, particularly against singlet oxygen. Singlet oxygen is an 'excited' ion of oxygen which, while not technically a free radical, is nonetheless highly reactive. It causes 'oxidative' reactions which can impair or destroy membranes, enzymes and DNA. It can also lead to the formation of free radicals which can cause additional damage. Certain carotenoids such as beta carotene, because of their chemical structure, can neutralize singlet oxygen by absorbing its extra energy and dissipating it throughout the carotenoid molecule, releasing the energy as heat and converting the singlet oxygen back to 'normal' oxygen. One molecule of beta carotene can quench up to 1000 molecules of singlet oxygen. In addition to their role as singlet oxygen quenchers, carotenes provide antioxidant protection against free radicals as well. In nature, they protect plants from photo-oxidative reactions; in humans, certain carotenoids, notably beta carotene, may help protect the skin from such reactions. Other carotenoids may provide more localized protection to particular organs. Lutein and zeaxanthin, for example, are selectively concentrated in the retina of the eye. Along with vitamins C and E, carotenes are among the most important nutrient antioxidants in the human body.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=250) R-Lipoic Acid - Fulfilling the Potential of Lipoic Acid
Date:
June 04, 2005 02:23 PM
Lipoic acid may be the body’s most versatile nutrient. Its critical importance for health is scientifically documented. Not only is it a powerful antioxidant, it supports healthy sugar metabolism and liver function, and is integral to energy generation, which affects all biological functions. But few know that the commonly available form, alpha lipoic acid (ALA), is not the same compound that occurs naturally in our bodies. ALA is a 50/50 combination of natural form r-lipoic and synthetic s-lipoic acid—and the synthetic form may actually block the activity of r-lipoic acid, resulting in a weaker product. Because it is the natural form, r-lipoic acid is better absorbed and safely metabolized. And it is up to 10 times more effective at producing cellular energy, according to in vitro research, and may be a more potent antioxidant. Source Naturals, the science company, is proud to be one of the first to offer this breakthrough nutrient: R-LIPOIC ACID R-Lipoic Acid: Key to Cellular Energy Generation Plants capture solar energy in their carbohydrates. In a reverse process called oxidation, animals extract that energy. R-LIPOIC ACID is a vital link in the metabolic pathway that gives us the power to move and the energy of intelligence. R-LIPOIC ACID is synthesized in the mitochondria, the tiny power plants inside every cell that produce energy in the form of ATP. It is safely metabolized and up to 10 times more effective than other forms of lipoic acid in mitochondrial ATP production, according to an in vitro study. Supports Glucose Metabolism Human and animal studies show that R-LIPOIC ACID can increase glucose uptake by muscle and nerve cells. By enhancing sugar metabolism, R-LIPOIC ACID may protect cells from glycation. In this detrimental process, excess glucose reacts with proteins to create tough crosslinked bonds that damage vital proteins, including the myelin sheath of neurons and the lens of the eye. Scientists believe glycation is a major source of tissue degradation and cellular aging. Collagen, another important protein, is also subject to crosslinking, which inhibits the flexibility of blood vessel walls—one of the most important indicators of cardiovascular health. Increases Antioxidant Protection R-LIPOIC ACID also neutralizes the harmful byproducts of glucose metabolism, free radicals. The body synthesizes barely enough R-LIPOIC ACID for its metabolic needs, and this decreases with age. As mitochondrial energy production becomes less efficient, more free radicals are generated. R-LIPOIC ACID protects cells, particularly in the mitochondria, where most oxygen damage occurs. R-LIPOIC ACID is a leading component of the body’s antioxidant network. Unlike other antioxidants, it is water and fat-soluble, so it neutralizes a greater number and broader range of free radicals, providing more protection. In animal studies, R-LIPOIC ACID slowed the aging process, which may be the result of cumulative oxidative damage. Lipoic acid, known as the “universal antioxidant,” is a strong antioxidant in its own right, but it also directly recycles vitamin C and indirectly recycles vitamin E for continued use. And R-LIPOIC ACID is more efficient than other forms of lipoic acid at increasing levels of the key antioxidants, CoQ10 and glutathione. Commercial alpha-lipoic acid is 50% synthetic s-lipoic acid, which can interfere with natural form R-LIPOIC ACID when both forms compete for binding sites. Tests showed 40% better absorption by R-LIPOIC ACID, as measured by plasma concentration levels. Integral to Your Wellness Program Because it is central to such critical functions as energy generation, antioxidant protection, anti-glycation activity, and liver support, R-LIPOIC ACID belongs at the center of your wellness program. Source Naturals is happy to join forces with your natural foods retailer in bringing you this advanced nutrient.
References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=190) PHOSPHATIDYL SERINE (PS) - Maintain healthy cells ...
Date:
June 04, 2005 11:08 AM
All we have ever known or will ever feel, begins and ends with the hundreds of billions of nerve cells that form our brain. Without them, there can be no experience; for us, nothing would exist. Our mind and personality, the sense of who we are, emanate from this immensely intricate system of nerves. The brain’s remarkable ability to perceive and perform, remember and learn, is severely challenged by today’s social and physical environment. These environmental factors accelerate the decline in nerve cell activity that normally occurs with age. Recent clinical research is revealing how previously unrecognized nutrients can strengthen the body’s natural defenses against age-related cognitive decline. Source Naturals is proud to present the latest breakthrough in nutritional support for the brain: PHOSPHATIDYL SERINE. Phosphatidyl Serine (PS) is a phospholipid which forms an essential part of every human cell, but it’s particularly concentrated in the membranes of nerve cells. Since the electronic messages that communicate and regulate every aspect of our lives travel along nerve cell membranes, the structural integrity of these membranes is imperative to our health. The nerve cell membrane is the site where molecules of sodium and potassium exchange electrons, causing the electrical impulse to be generated. This bio-electric current then travels along the membrane to trigger the release of neurotransmitters. These are the chemical messengers that cross synapses (gaps between nerve cells) to relay information to neighboring nerve cells. This sets other electrical currents in motion– along thousands of other nerve cells. This happens billions of times each second, and is how the brain and nerves coordinate and communicate with the rest of the body. PS has a very important function in the nerve cell membrane. As a key bio-structural molecule, PS provides vital support for the membrane proteins that enable nerve cells to communicate and grow. Regulating the Flow Unlike other cells in the body, nerve cells do not reproduce. Instead, they repair and rebuild themselves, using proteins called Nerve Growth Factor (NGF). Experiments verify that PS enhances the synthesis and reception of NGF, which tend to drop off radically with age.1 PS supplements enhance the cerebral cortex’s output of acetylcholine, the neurotransmitter associated with our ability to think, reason, and concentrate. PS also stimulates the synthesis and release of dopamine, related to heightened states of attention.2 The brain’s response to stress also appears to be related to PS. When healthy young men were subjected to exercise-induced stress, those taking PS had a lowered stress response. This was measured by blood levels of ACTH, the pituitary hormone that triggers the adrenals to secrete the stress hormone cortisol.3 Well-Tested Subjects taking PS showed increased levels of brain energy metabolism and scored higher on cognitive tests.4 Behavioral factors were also measured in elderly subjects; PS positively affected their mood states.5 Over 23 clinical trials have investigated the effect of PS supplements on more than 1200 human subjects, ages 40-93. Consistent and statistically significant results suggest that PS supports brain functions that tend to diminish with age. Wellness Redefined Nutritional research continually reveals new potentials for wellness. Source Naturals is committed to helping people achieve a fulfilling life, and a fully functioning nervous system is central to this aim. Source Naturals PHOSPHATIDYL SERINE can help support your body’s natural regenerative processes, keeping your brain healthy and vital for a long, long time. Experience the difference with Source Naturals PHOSPHATIDYL SERINE.
References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=183) OptiZinc - The king of Zinc ...
Date:
June 04, 2005 10:43 AM
Source Naturals brings you yet another breakthrough in mineral nutrition: OptiZinc! Opti Zinc is Zinc Monomethionine — Zinc combined with the essential amino acid Methionine. It is FDA approved as safe for human nutrition, and is so unique, it’s patented. Opti Zinc — THE MOST POTENT FORM OF ZINC AVAILABLE Extensive scientific research shows that Opti Zinc is the most bioavailable and bioactive form of Zinc tested.1 Aside from demonstrating superior absorption and utilization by the body for Zinc’s many functions, Opti zinc is also more efficient than other forms of Zinc in getting needed Vitamin A out of storage in the liver, thus making it available for use.2 Perhaps most outstanding is the synergy offered by this combination of Zinc and Methionine: while both of these nutrients are well-known for their freeradical- neutralizing properties, the antioxidant activity of Opti Zinc far surpasses that of either Zinc or Methionine alone. ZINC — ESSENTIAL FOR YOUR HEALTH Zinc is one of the most important minerals your body uses. Among its many functions, Zinc is: ? critical for the health of the thymus gland, which is necessary for the natural defenses, as demonstrated in recent research by Nicola Fabris, Ph.D., director of the Gerontology Research Department of the Italian National Research Center on Aging in Ancona, Italy;3 DO YOU GET ENOUGH ZINC IN YOUR DIET? As vital as Zinc is, it can be hard to get enough of, even when following a healthy diet. Surveys show that the daily intake of Zinc in the average American diet ranges from 8 to 11 mg, yet the U.S. RDA is 15 mg. The few excellent sources include seafoods (such as oysters, herring, and clams), whole oatmeal, wheat germ, wheat bran, and milk.4 If some of these are not a regular part of your diet, you may be one of many people who are Zinc deficient, and you may want to use a dietary supplement. SOURCE NATURALS™ — Opti Zinc THE SUPPLEMENT OF CHOICE One Source Naturals’ Opti Zinc tablet provides 30 mg of Zinc (from 150 mg Opti Zinc Zinc Monomethionine), which is 200% of the U.S. RDA for Zinc. 300 mcg of the essential mineral Copper is also included, to offset the displacement of Copper that can occur when high levels of Zinc are consumed. The form of Copper used is also state-of-the-art: it is Copper Sebacate, a natural compound that is Copper:SOD-mimetic, meaning that even on its own, it can act as an antioxidant. Its inclusion with Zinc Monomethionine makes Source Naturals’ OptiZinc a powerful antioxidant combination that is truly on the cutting edge of nutrition science. OPTI ZINC® brand of Zinc Monomethionine complex is a trademark of InterHealth Company; U.S. Patents Nos. 3,941,818, 4,021,569, & 4,764,633. Source Naturals’ OPTI ZINC® is all-Vegetarian and hypoallergenic: contains no yeast, dairy, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=182) Heart Science - A Five-Tiered Approach to Heart Health ...
Date:
June 02, 2005 12:07 PM
Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available. Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health
Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for Energy Generators for An Energetic Organ Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply. There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently. CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10 Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound. Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21 HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells. Homocysteine Regulators B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization. The Dangers of Oxidized LDL Cholesterol While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL. When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse. The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes. Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol. Cholesterol Fighters Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits: The Regulating Trio Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings. Artery Lining Protectors Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6 Capillary Strengtheners Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart. Heart Smarts The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care. Source Naturals HEART SCIENCE™
Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=155) new treatment options for chronic hepatitis 
Date:
May 30, 2005 10:11 AM
Can science meet the challenges of the HCV pandemic: new treatment options for chronic hepatitis C. Roehr B Journal of the International Association of Physicians in AIDS Care (1998 Jul), 4(7), 24-9. Journal code: 9508185. ISSN:1081-454X. United States. (NEWSPAPER ARTICLE) written in English. PubMed ID 11365638 AN 2001282246 MEDLINE Abstract New treatment options for chronic hepatitis C (HCV) infection are examined. Studies show the efficacy of interferon alfa-2b in normalization of serum alanine aminotransferase and histological improvement in necroinflammatory liver disease. However, 70 to 80 percent experiencing normalization usually relapse within 1 year after treatment. Ten to 20 percent will have a sustained response lasting at least 3 years. Ideas for improving treatment response include longer initial treatment regimens, increasing dosages of interferon alpha, or adding another agent to interferon alpha. Based on encouraging study results, the interferon/ribavirin combination has been approved by the Food and Drug Administration (FDA) in HCV patients relapsing following interferon alpha monotherapy. So far the FDA has approved interferon alfa-2b, interferon alfa-2a, alfacon-1, and interferon alfa-2b/ribavirin as treatments for HCV; ribavirin alone is not effective against HCV infection. Other drugs are being tested with interferon alpha but have not generated enough substantive data. Thymosin, an immune modulator that enhances the body's production of interferon and interleukin rather than attacking HCV directly, is also being investigated. Oral dosing of interferon is in clinical trials for hepatitis B, and the results may be applicable to HCV. Alternative therapies are gaining wider interest such as using milk thistle for liver regeneration or using licorice root for quelling liver inflammation. As for transmission risk, there is little evidence supporting sexual activity as a major risk factor, however, some risk is reported with anal intercourse, sex during the menstrual cycles, and years of cohabitation with an infected partner.
NADH 5mg
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=112) | ||||||||||||||
What is hyaluronic?
Arnica medicinal qualities
Unfortunately our skin health will always deplete as we age and it is a normal thing to happen to anyone. There are various ways that one can improve his or her skin health. As much as there are several method for one to use, Hyaluronic acid cream has generated much hype in this particular topic.
Doubtlessly, there are few preferred healthy skin items over cocoa butter and some few that likewise makes you feel great deductively notwithstanding feeling extraordinary because of the way your skin looks so great, but Cocoa butter is good solid skin reinforcement, and for additional data on characteristic healthy skin items with a great experimental foundation. Therefore it is good for the skin.
Premestrual Syndrome (PMS)
CoQ10 and L-Carnitine offer double protection for the heart and the brain in just a single tablet. You obtain all benefits for your heart at 100% from CoQ10, while L-Carnitine supports your memory, learning ability, and focus. The exclusive combination of CoenzymeQ10 and L-Carnitine encloses an absorbable, water soluble capsule of CoQ10 and L-Carnitine, which is important for proper usage.
Glutathione is a simple protein that consists of three amino acids. These amino acids include glutamic acid, cysteine, and glycine. Due to the chemical nature of sulphur-containing cysteine, glutathione is able to effortlessly donate electrons. This ability is the reason why it has powerful antioxidant properties. Intracellular glutathione status is a sensitive indicator of cellular health and of the cell’s ability to resist toxic challenges. 
