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Search Term: " mouse "
Heart-healthy curcumin improves muscle function and increasesexercise capacity   
Date:
May 13, 2019 04:10 PM
There's a lot of buzz about curcumin these days and for good reason. A recent study published in The Journal of Applied Physiology suggests that it can help to improve athletic performance in heart failure patients. Other research has shown that it could reduce muscle loss in individuals with heart disease. Due to its potent antioxidant and anti-inflammatory effects properties, it also can be a very effective post-workout supplement. In fact, researchers found that people that consumed one gram of curcumin twice daily had decreased muscle injuries and less pain in their lower legs. Key Takeaways:
"For the study, researchers from the University of Nebraska Medical Center looked at the effects of curcumin on a mouse model of heart failure with reduced ejection fraction. The compound is known to promote activation of Nrf2 protein, which regulates the expression of antioxidant enzymes that prevent and repair damage from oxidative stress and boost exercise performance." Read more: https://www.naturalnews.com/2019-03-18-curcumin-improves-muscle-function-exercise.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6309) Shiitake mushrooms are a powerful medicinal superfood 
Date:
May 09, 2019 02:09 PM
A new study has found that adding fermented shiitake mushroom to rice bran is effective in inhibiting the growth of Salmonella typhimurium. The study was conducted on mouse organs and it was published in the journal BMC Complementary and Alternative Medicine. This formulation has been hailed as a new antimicrobial food-compatible formulation. The study was conducted on murine macrophage cells and in mice. Before this, it was known that the bioactive compounds in rice brans and in shiitake mushrooms have a lot of potential health benefits in mice, cells, and rodents. When the mycelia cells were compared against non-fermented ones, it was found that the bioactive compounds present in the fermented shiitake mushrooms could not be found in the ones that had not fermented. Further findings showed that the pathogen, Salmonella, was inhibited in infected macrophage cells and in organs in the mouse such as the cecum, mesenteric lymph node, spleen, and the liver. Another finding was that there was increased secretion of the bacteria in the feces in mouse. Overall, this findings show that fermented shiitake mushrooms with rice brans can be used as an antibiotic and antimicrobial food. Key Takeaways:
"A study published in the journal BMC Complementary and Alternative Medicine found that a formulation of fermented shiitake mushroom with added rice bran can inhibit the growth of Salmonella typhimurium in infected mouse organs." Read more: https://www.naturalnews.com/2019-04-16-shiitake-mushrooms-are-a-powerful-medicinal-superfood.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6292) Eating cruciferous greens help your immune system fight offintestinal pathogens
Date:
January 13, 2019 04:10 PM
The Francis Crick Institute has published new research on the useful properties of cruciferous vegetables in protecting against pathogens that attack your gastrointestinal tract. According to this research, kale, broccoli, and cauliflower can all help reduce your susceptibility to inflammatory bowel diseases. They do this by helping to mitigate the effects of a compound called Cyplal, which can inhibit your body’s ability to use a separate substance called aryl hydrocarbon receptor (AhR). This is good because when Cyplal interferes with AhR, it can leave you more vulnerable to gut parhogens. Key Takeaways:
"An article in The Francis Crick Institute news page reported that cruciferous vegetables are particularly beneficial when it comes to shielding the intestine from disease-causing microorganisms." Read more: https://www.naturalnews.com/2018-12-18-eating-cruciferous-greens-help-your-immune-system-fight-off-intestinal-pathogens.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5960) Gut microbes play a significant role in the central nervous system digestive health is linked to your risk of neurodegenerative diseases
Date:
August 07, 2018 09:53 AM
Neurodegenerative diseases like Alzheimers are becoming more and more common in the United States, and pose an increasing risk to aging populations. A recent study has identified gut microbes as one of the causes of these diseases - a huge breakthrough in the field, and one with significant implications for how we view our brain's health. These microbes release chemicals that can change the nature of the brain. It's a finding that shows that caring for our digestive health can be one of the most important steps to preventing diseases like Alzheimers, later on. Key Takeaways:
"They reached their conclusions after examining gut microbes and changes in mouse models of multiple sclerosis. They discovered the compounds produced by the breakdown of tryptophan cross the blood-brain barrier and activate an inflammatory pathway that can limit neurodegeneration." Read more: https://www.naturalnews.com/2018-07-30-gut-microbes-play-a-significant-role-in-the-central-nervous-system.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5695) A flavonoid found in guava and Osage orange has antioxidant properties that can reduce inflammation and improve “neurological deficits”
Date:
January 23, 2018 07:59 AM
There was a study conducted at the Harbin Medical University in China that found that Morin, a flavanoid in guava and osage oranges could lessen inflamation and increase neurological deficits. It also has anti inflamation properties. In labratory mice this flavanoid seemed to reduce inflamation and restored the ability to walk, talk ( which is strange for a labratory mouse.), decreased mental function issues, and decreased loss of balance, and a weakness in the arms and legs. Essentially the study found that the flavanoid morin helped to counter act certain types of strokes, to increase motor functions to the patient. Key Takeaways:
"A person who smokes, drinks excessive amounts of alcohol, uses cocaine or methamphetamines, is overweight, or has diabetes is at risk of developing cerebral ischemia." Read more: https://www.naturalnews.com/2018-01-21-a-flavonoid-found-in-guava-and-osage-orange-antioxidant-properties.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5501) Mice fed tryptophan develop immune cells that foster a tolerant gut
Date:
August 13, 2017 09:14 AM
Tryptophan is a fundamental building block of protein. A study was conducted on genetically identical mice that were separated and raised in different environments, which led to the finding that environmental factors were a high contributor in regards to developing an immunity to irritable bowel disease. Bacteria highly affects the immune system because the mice that were raised in sterile conditions grew the immune cells. Doctor Luisa Cervantes-Barragan conducted the study. Tryptophan is common in both mouse and the human balanced food diet. Key Takeaways:
"People have the same tolerance-promoting cells as mice, and most of us shelter L. reuteri in our gastrointestinal tracts." Read more: https://medicalxpress.com/news/2017-08-mice-fed-tryptophan-immune-cells.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5119) Air pollution may directly cause those year-round runny noses, according to a mouse study Johns ...
Date:
April 27, 2017 10:59 AM
Are you one of those who always seems to have a runny nose? There are kids who go around like this a lot as well. You may be wondering what causes it. You probably think it's a cold or some sort of sinus infection that needs medications but you could be wrong about. This can also be caused by air pollution according to recent studies. Air pollution causes many problems and this is just another one. Read more: Air pollution may directly cause those year-round runny noses, according to a mouse study Johns ...
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4489) 'Good' bacteria is potential solution to unchecked inflammation seen in bowel diseases
Date:
March 16, 2017 01:44 PM
Valuable microscopic organisms might be the way to turning around a cycle of gut irritation found in certain fiery inside ailments, College of North Carolina Lineberger Far reaching Tumor Center scientists have found. Scientists found that including back a sort of advantageous microscopic organisms that ordinarily develops in the gut can help end this cycle, recommending another treatment for incendiary inside ailment. The two most basic fiery entrail infections, Crohn's illness, and ulcerative colitis influence an expected 1.6 million individuals in the Unified States, as indicated by the Crohns and Colitis Establishment of America. They trust their discoveries could conceivably prompt to medications for individuals with fiery gut illnesses with diminished NLRP12 expression. You can focus on the irritation that downstream of NLRP12 with mitigating medications, or you could simply nourish the creatures particular microscopic organisms that advantage, and it causes a move that made them less defenseless to the ailment. Key Takeaways:
"NLRP12 has been known to suppress inflammatory signals to prevent an overactive immune response. But an analysis uncovered low levels of NLRP12 in twins with ulcerative colitis, but not in paired twins without the disease. And in mouse models that lacked this protein, they found higher levels of inflammation in the colon." Read more: https://www.sciencedaily.com/releases/2017/03/170313135055.htm
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4177) Curcumin helps to effectively ease inflammatory bowel disease: China mouse study
Date:
February 21, 2017 07:59 AM
Curcumin, a substance in turmeric, can halt progression of inflammatory bowel disease. Researchers in a leading Chinese university induced colitis in mice and treated them with the substance. Mice treated had a decrease in inflammatory cell infiltration into the colonic mucosa. It does this by suppressing dendritic cell activation which are responsible for creating bowel inflammation. Key Takeaways:
"Curcumin can help suppress the activation of dendritic cells (DCs), which play a pivotal role in the progression of inflammatory bowel disease, research from China has discovered." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3987) Schools are filled with bacteria, causing crippling lung function in children
Date:
December 19, 2016 07:59 AM
Sure, when you send your kids to school you worry about a lot of things: Fitting in, bullying, learning but never did you think that you would have to worry about bacteria from mice and other rodents. Researchers have shown that bacteria in school has caused an increase in asthma in school age kids. This is increasing at such an alarming rate that it finally caught the attention of health officials even though the effects have been happening for years. Key Takeaways:
"Some 284 children from 37 inner-city public schools located throughout the Northeastern United States were evaluated as part of the research." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3670) Enzyme that digests vitamin A also may regulate testosterone levels
Date:
December 15, 2016 10:59 AM
Want to help regulate testosterone in the body? Well a new enzyme was just discovered that helps break down enzymes in the body that regulate and make the most out testosterone. This could be important for testosterone replacement therapy. It is a good breakthrough, it can help those in need. Key Takeaways:
"The scientists also found evidence that androgen receptor signaling was disrupted in the mice without the Bco1 gene." Reference: https://www.sciencedaily.com/releases/2016/12/161207124055.htm
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3650) Why wounds heal more slowly with age
Date:
December 01, 2016 06:59 AM
Our bodies undergo many changes when we age. Once potentially problematic change is that our bodies take longer to heal when we are older. This phenomenon has been observed since WWI. Recent studies at Rockefeller University have focused on observing young and elderly mice to determine why this happens. It has been discovered that our immune cells stop communicating effectively in old age, which leads to them not doing their jobs as quickly as when we are young. Key Takeaways:
"Recent experiments at The Rockefeller University explored this physiological puzzle by examining molecular changes in aging mouse skin." Reference: https://www.sciencedaily.com/releases/2016/11/161117151059.htm
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3542) A metabolic switch to turn off obesity
Date:
November 01, 2016 04:04 PM
Here’s some good news to cheer you up. If you’ve been fighting a losing battle trying to lose weight, maybe you should quit beating yourself up about it. A new University of Montreal study of mice says when an enzyme is blocked in some neurons in the mouse brain, it becomes impossible for the mice to lose weight even when they stick to an ideal regime. So now you can blame it all on the ABHD6 enzyme. Key Takeaways:
"A research team at the University of Montreal Hospital Research Centre (CRCHUM) has generated genetically engineered mice, deprived of the ABHD6 enzyme in a localized area of the brain, namely in a specific population of hypothalamic neurons." Reference: https://www.sciencedaily.com/releases/2016/10/161027115843.htm
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3368) Jojoba Oil
Date:
August 28, 2009 01:50 PM
Jojoba is a shrub that is native to the Sonoran and Majoave desserts of Arizona, California, and Mexico. It is the only species in the family SImmondsiaceae. Sometimes, it is also placed in the box family, Buxaceae. This herb is also known as goat nut, deer nut, pignut, wild hazel, quinine nut, coffeeberry, and gray box bush. The jojoba plant grows one to two meters tall and has a broad, dense crown. The leaves are opposite, oval in shape, and approximately two to four centimeters in length and 1.5 to 3 centimeters wide. The leaves are thick, waxy, and gray-green in color. The flowers are small and greenish-yellow in color. They have five to six sepals and no petals. Each plant is neither male or female. Hermaphrodites in this species are extremely rare. The fruit of the jojoba plant is an acorn-shaped ovoid that is one to two centimeters long. The mature seed is a hard oval, dark brown in color, and contains about fifty-four percent oil. Jojoba foliage gives a year-round food opportunity for many animals. Among these include deer, jaelina, bighorn sheep, and livestock. The nuts are often eaten by squirrels, rabbits, other rodents, and larger birds. The only animal known to be able to digest the wax that is found inside the jojoba nut is the Bailey’s Pocket mouse. The seed meal is toxic to many mammals when taken in large quantities. The indigestible wax often acts as a laxative in humans. Native Americans in Arizona, California, and northern Mexico used jojoba for the hair and as a tonic for the body. The herb is a valuable crop for some Native American tribes in those areas. This herb can be found in shampoos, conditioners, moisturizers, and sunscreens. Jojoba oil, which is made from the seeds of the plant, has been used traditionally by Native Americans. They use this herb to promote hair growth and relieve skin problems. Jojoba helps to remove the sebum deposits that are responsible for causing dandruff and scalp disorders. This herb is responsible for making the scalp less acidic. One study found the wax that is in the jojoba oil to treat acne and psoriasis. This herb has traditionally been used successfully for this purpose. In addition, it is used to heal minor skin irritations. A study on rabbits found that those who were fed jojoba oil had a reduction of forty percent in their blood cholesterol levels. The reason or component that is responsible for this activity still remains unknown. The oil of the jojoba plant is used to provide emollient properties. The primary nutrients found in jojoba are chromium, copper, iodine, silicon, vitamins E and B complex, and zinc. It is important to consult your health care provider before consider using this or any other supplement while on prescription medications. Primarily, jojoba is very beneficial in treating dandruff, hair loss, psoriasis, and dry scalp. Additionally, this herb is extremely helpful in dealing with abrasions, acne vulgaris, athlete’s foot, cuts, eczema, pimples, seborrhea, mouth sores, warts, and wrinkles. For more information on the many benefits provided by jojoba, please feel free to contact a representative from your local health food store with questions.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2067) Gymnema Sylvestre
Date:
November 12, 2008 09:51 AM
Gymnema sylvestre is found naturally in central and southern India, where it has been used in traditional Indian medicine for almost two thousand years. It is known as 'gurmar' in ancient Indian texts, a word meaning 'sugar destroyer', which gives an indication of its uses in medicine. It is used to reduce the absorption of glucose into the body, and also reduce the sweetness of foods, both of which are desirable for those wishing to lose weight and to reduce the level of sugar in their blood. It was used for this purpose in Ayurvedic medicine, subjects being given the leaves to chew. As with many other ancient Ayurvedic remedies, this use of gymnema sylvestre has passed into modern times, and has sound scientific basis. First, however a bit more about the plant itself. It is found predominantly in the Western Ghats, and also to the west of the mountains, around coastal Goa. It is a vinous plant that climbs on other bushes and trees, known in Sanskrit as Meshasringa, or ram's horn after the shape of the leaves from which the supplement is extracted. For what it's worth, the official name seems a mix of Greek and Latin (gymnos(Gr) - naked and Silva (L)- forest) for naked forest. That, however, is irrelevant to its uses, so let's have a look at the science involved and the active ingredients in the plant. The main constituents are terpenoid saponins known as gymnemic acids, so one can assume that they were first found in this plant. They are glycosides, including hodulcine and ziziphin, which act as sweetness inhibitors so that there is no sweet taste in anything that is sweetened by sucrose. There are over 20 types of gymnemic acid in the leaves, of which the strongest, Gymnemic Acid 1, can suppress the sweetness even of artificial sweeteners such as aspartame. These are not irreversible effects, and last only about 10 minutes, after which normal sweetness is detectable by your tongue. During the active period, however, a solution of normal sugar will taste like ordinary unsweetened water. However, is this just a matter of taste, or does it affect the sugar itself? Studies have shown that animals fed the leaves of Gymnema sylvestre develop hypoglycemia, probably because it stimulates the pancreas to generate insulin that reduces the level of sugar in the blood. Further studies have shown the presence in the leaves of a number of types of acylated derivatives of deacylgymnemic acid. There are well over a dozen types of saponins known to be contained within the leaves. Other chemicals found include anthraquinones, flavanoids, chlorophylls, querticol, phytin, a number of glycosides and anthraquinones. The bush also contains alkaloids, although these are constituents in most plants used in ancient remedies. This is by no means all of the chemicals discovered, and many of the minor benefits of using it could be due to the minor constituents of this amazing little leaf. A study of the above constituents will reveal a few antioxidants, and it is no surprise that the extract from Gymnema sylvestre also possesses anti-inflammatory properties. Gymnemic acid is believed to have a similar chemical structure to saccharose, and the plant extracts can be used not only to reduce a craving for sugar, but also to treat digestive problems and high cholesterol levels. So what scientific evidence is there other than the obvious effects reported by those that use it? A study in the UK in 2005 found that an aqueous extract of Gymnema sylvestre caused the secretion of calcium and insulin from mouse and human cells to be increased at a specific concentration without affecting the cellular function. This means that the supplement can be used to stimulate the secretion of insulin with people with Type 2 diabetes without otherwise affecting health. Its usefulness to diabetics is obvious, but there are other health benefits to those that are not diabetic. Anything that modulates a sweet tooth must be of use to those seeking to lose weight, particularly if they feel the need for sweet foods. In fact Gymnema tends to reduce food cravings for carbohydrates and sweets, and can be used by those seeking a natural means of curbing their appetite for sweet and sugary foods. Because excess weight can lead to diabetes, Although there have been many discussions about the biochemical mechanism of the gymnemic acids in this effect on taste, recent evidence suggests that the phytochemicals act on both your taste buds and on those parts of the intestine responsible for absorbing nutrients from digested foods. Not only that, but studies have also indicated that Gymnema sylvestre removes the bitterness of acerbic chemicals such as quinine in the same way that it removes the sweetness form cakes and candies, and if you drank tonic water it would taste just like water. On the other hand, if you ate an orange, you would taste the acidity but not the sweetness. The way to use this remarkable supplement is to follow the instructions, and within about a week you will be able to control your appetite much better, and any cravings for carbohydrates you previously had will be much reduced. After a month or so, you will notice an accelerated rate of weight loss if you had been overweight, and diabetics will find a significant reduction on blood sugar between insulin shots.
Gymnema sylvestre can take care of any sugar or carbohydrate cravings, and is of significant use to the overweight, obese or to diabetics, and the mechanism by which it works has now been all but understood, although there are still some biochemical secrets that this amazing plant has yet to reveal. This amazing herb can be found at your local or internet vitamin store.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1935) On Tuesday, April 8, the Natural Products Association - 11th Annual Natural Products Day
Date:
April 10, 2008 04:46 PM
On Tuesday, April 8, the Natural Products Association and our sponsors will be hosting the 11th Annual Natural Products Day in Washington, D.C. This day is an important way for natural products advocates to reach out to Congress and discuss the issues that matter. For more information on Natural Products Day or to register, please visit www.NaturalProductsAssoc.org/npd08. Among the many healthy policies we’ll be asking members to promote on Capitol Hill, bill S. 770, Food Stamp Vitamin and Mineral Improvement Act, will be at the top of our list. S. 770 would give needy food stamp recipients the choice of purchasing certain vitamin and mineral supplements with their benefits, in the same way they are free to make other dietary choices. If the stamps can be used to buy a soda or snack cake, why not use them to buy a supplement to improve your health? These select supplements could improve appetite and growth rates in poor children; decrease infectious disease in the elderly; prevent neural tube birth defects; protect against heart disease and stroke; protect against some cancers; maintain cognitive function in the elderly; and build bone mass in the young and decrease bone loss in the old. But, you don’t have to go to the Hill to make a difference! If you can’t join us in Washington, D.C., you can still e-maiL your elected officials and tell them to support S. 770! Don’t miss this chance to put your stamp of approval on this important bill! Take Action Now!
Click here to e-mail your elected officials
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1749) Extended existence?
Date:
May 28, 2007 11:33 AM
Humankind has long searched for a special elixir that would confer immortality…or, failing that, at least prolong youthful vitality for a decent number of years. Resveratrol is no magic potion, but it has improved survival rates among mice at the ripe old age (for a mouse) of 114 weeks even overweight mice fed high-calorie chow (Nature online 11/1/06). What’s more the Resveratrol bolstered rodents stayed fit and trim well into their senior years; as Dr. Rafael de Cabo of the National Institute on Aging told the news service heartwire, such a finding “suggests that this compound may not just extend life but may also enable individuals to lead healthy and functional lives for longer.” While tests continue on how Resveratrol could produce these results, it is believed that this substance may actually mimic the effects of calories restriction, which has been shown to increase longevity. Resveratrol apparently activates a gene known as SIRT1 activation is also associated with greater exercise capacity and fat burning.) in addition, Resveratrol both acts as an antioxidant itself by mopping up dangerous molecules called free radicals and helps enhance the antioxidant effects of vitamin C and E.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1545) EpiCore Benefits
Date:
April 09, 2007 05:02 PM
EpiCor® is a unique and novel dietary supplement used for support of immune health, with a fascinating history of discovery. In 1943, a company in
Interestingly, when the company became self-insured, they became aware of unusually low rates of illness in employees that worked in the manufacturing plant for this animal product. This led to very low increases in their insurance premiums over the years compared to other companies, saving them quite a lot of money. Hence they began to investigate what might be the cause of the “healthfulness” of the employees at the fermentation plant. This investigation and subsequent research studies led to the formation of a new company called Embria Health Sciences, which now produces EpiCor® as a supplement for humans to support immune system health.1 Doctor’s Best® is proud to now offer the benefits of EpiCor® to its customers.
Beneficial Support of the Immune System and Activation of Natural Killer (NK) Cells in vitro*
A comparison study was performed on blood from 10 fermentation plant workers compared to that from 10 age and gender matched controls. The fermentation plant workers had several immune cell parameters that appeared superior to the control group. These included decreased levels of CD8 cells resulting in significantly increased CD4 to CD8 ratios, significantly improved cytotoxic natural killer (NK) cell activity even though total NK cells were decreased in number, higher killing efficiency of NK cells, significantly increased levels of secretory IgA, increased numbers of EpiCor™ specific antibodies, higher levels of red blood cell intracellular glutathione, and significantly lower levels of immune complexes. These results represent benefits on various cellular players of both the specific and innate parts of the immune system.1,3,4
NK cells are one of the first lines of defense used by the immune system. An in vitro study performed on human cells showed that NK cells were activated after incubation with EpiCor®, as evaluated by expression of the CD69 activation marker. The CD25 marker (IL-2 receptor) was also induced in the NK cells, although to a lesser degree.1,2 B cell activation was also noted through increased expression of CD80 and CD86 markers.2 Immediate increases in calcium levels were evident in peripheral blood mononuclear cells after exposure to EpiCor®, suggesting increased activation through calcium regulation.2
High Metabolite Immunogen*: Nutrient Make-up
Production of EpiCor® utilizes the common and harmless bakers or brewers yeast Saccharomyces cerevisiae in a patented process called MetaGen4™, a multi-stage fermentation and drying process. It differs from other yeast products in that it contains both the yeast itself as well as the metabolites or “nutrilites” formed by the fermentation process, which are present in the media.1 Together the media containing the metabolites and the yeast are dried to form EpiCor®. Analysis of EpiCor® reveals that it contains a mixture of natural polyphenols, phytosterols, beta-glucans, mannan oligosaccharides, fiber, trace amounts of B vitamins and minerals, as well as a host of other nutritional compounds.1,2
Beneficial Antioxidant Activity*
EpiCor® was tested for antioxidant activity in an in vitro assay called the Oxygen Radical Absorbance Capacity assay (ORAC). In this assay, EpiCor® was shown to have a total ORAC antioxidant level of 610 micromol TE (tocopherol (vitamin E) equivalents) units (ORAC units) per gram dry weight, which soared above other high antioxidant level foods such as cranberries (93 ORAC units per gram dry weight) and blueberries (62 ORAC units per gram dry weight).1,3,5
In another study, freshly isolated human neutrophils were treated with EpiCor® followed by the free radical generator hydrogen peroxide. Cells were treated with a dye that fluoresces when attacked by free radicals. Those cells treated with EpiCor® showed decreased fluorescence intensity compared to control cells not treated with EpiCor®, verifying antioxidant activity in vitro.2
Safety
Numerous safety tests have been conducted on EpiCor®, revealing an extremely safe profile. Animal studies performed by a leading toxicology laboratory showed no indication of any toxic effects of EpiCor®. An acute oral toxicity study on 20 rats showed that the product was safe when given to rats at a single oral dose of 2000 milligrams per kilogram of body weight (equivalent to a human ingesting 280 capsules at once). After 2 weeks the rats showed no clinical symptoms, no deaths, no abnormalities in body weight, and no gross pathological changes. The same safety results were found in a subchronic toxicity study where rats were given up to 1500 milligrams daily for 90 days (equivalent to a human ingesting up to 210 capsules daily for 1.5 years). Again, absolutely no signs or symptoms of toxicity were noted in these animals.1,3
In addition, a standard bacterial reverse mutagenicity test (AMES test) as well as a mammalian cell mutation assay using mouse lymphoma cells revealed no evidence of any increase in mutation rates after exposure to EpiCor®. EpiCor® also showed no evidence of mitogenicity (inducing increased cell division) in a human lymphocyte proliferation assay. This suggests that EpiCor® does not cause over-reactivity of cells1,3.
The effect of EpiCor® on specific liver enzymes CYP1A2 and CYP3A4 (enzymes involved in metabolizing certain drugs and other compounds) was assessed. Immortalized hepatocytes (liver cells) were treated with various concentrations of EpiCor® and compared to both positive and negative controls. EpiCor® did not increase the expression or activity of the liver enzymes, suggesting that it may not affect the metabolism of other substances or medications metabolized by these enzymes if they are taken simultaneously. It also did not appear to be toxic to the cells as measured by lactate dehydrogenase assays and microscopic analysis.1
Lastly, EpiCor® was tested for safety in humans in an open label study on 15 adult men and women given a single 500 milligram dose for 30 days. On various days throughout the study vital signs were monitored, and blood and urine samples were analyzed. No clinically relevant abnormal effects on the participants were found1.
EpiCor® also currently has received self-affirmed Generally Regarded as Safe (GRAS) status by an expert panel that included eminent toxicologists1.
EpiCor® is a novel compound with an incredibly unique composition that has been shown to enhance immune system function.*
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Scientific References
1. Embria Health Sciences
2. Hart et al. A new Saccharomyces cerevisiae based product has anti-inflammatory effects while specifically activating human NK and B lymphocyte subsets. Unpublished study, personal communication.
3. Schauss AG, Jensen G, Vojdani A, Financsek I. After decades of ingestion by farm animals, the discovery of a yeast fermentate with unexpected significant immune modulatory activity when consumed by humans. [abstract] Journal of the
4. Schauss AG, Vodjani A. Discovery of an edible fermentation product with unusual immune enhancing properties in humans. [abstract] FASEB J, 2006; 20(4):A143.
5. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1508) Benefits of Acetyl-L-Carnitine
Date:
February 12, 2006 01:55 PM
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1216) GREEN TEA CAN PROTECT THE SKIN
Date:
August 22, 2005 02:36 PM
A recent study appearing in the Archive of Dermatology revealed that green tea has been shown to inhibit inflammation and cancer in the skin. The study revealed “green tea polyphenols were found to afford protection against chemical carcinogenesis as well as photocarcinogenesis in mouse skin.” The report states that a few experimental studies were conducted with human skin. While green tea has revealed its antioxidant, anti-inflammatory, and anticarcinogenic properties in the lab, researchers caution consumers that little is known about the restorative and protective measures in current skin-care products sold in grocery and department stores, as they are unlikely to “have been tested in controlled clinical trials.” Yet, their scientific findings are encouraging. “Although more clinical studies are needed, supplementation of skin care products with green tea may have a profound impact on various skin disorders in the years to come.”
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=742) REFERENCES
Date:
June 22, 2005 09:57 PM
REFERENCES
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=401) Botanical Arsenal - Plants can help our bodies fight off cancer's deadly ...
Date:
June 13, 2005 10:31 AM
Botanical Arsenal by Fred Thomas Energy Times, May 3, 1999 The complexities surrounding the various types of cancer stem from the variety of ways in which these diseases can wreak their havoc. Luckily, the equally complex world of plants contains novel compounds that can help our bodies fight off cancer's deadly progress. Research Expands Research into these botanical compounds is mushrooming. An example: The mighty maitake, a fungus with flair, alternately known as the king (it can grow as large as a basketball, worth its weight in silver to the ancient Japanese); the prince; the Hen of the Woods (it sticks out of from trees when it grows in the wild); and the dancing mushroom to those who leaped for joy when they found one growing in its native northeastern Japan. Researchers today dub it with a new moniker: Herbal Heavyweight. Mushroom with Potential The maitake, with such other medicinal mushrooms as shiitake and reishi, historically has been eaten to promote general well-being and vitality. In the modern lab, however, scientists focus on the potent immune enhancing powers of maitake, which spotlight its cancer fighting potential. Twenty years ago, maitake, Grifola frondosa, was an obscure, largely unavailable mushroom. A series of significant Japanese studies then catapulted it into prominence-and popularity. Maitake Magic Hiroaki Nanba, PhD, of the department of immunology at Kobe Women's College of Pharmacy on Kobe, Japan, and a leading international researcher on maitake, conducted the preliminary tests on the mushroom, demonstrating that it stimulates immune function and inhibits tumor growth. In 1986, Dr. Nanba fed powdered maitake to mice injected with tumor cells; 86.3% displayed inhibited tumor growth. Dr. Nanba and his colleagues went on to run additional mouse tests, finally reporting that this potent mushroom "directly activates various effector cells (macrophages, natural killer cells, killer T-cells, etc.) to attack tumor cells." From then, maitake mushrooms were headed to fame as cancer ninjas. Stoking The Immune Engine Like other mushrooms, maitake is rich in complex polysaccharides, immunomodulators that successive tests after Dr. Nanba's have shown to be effective in cancer and AIDS treatment. The polysaccharides in maitake have a unique structure, rendering them some of the most powerful to be studied (Chem Pharm Bull 1987:35:1162-8). What makes maitake a particularly hot property is beta-D-glucan, its primary polysaccharide. Studies show that the body absorbs it readily, at which point it effectively stimulates interleukin-1, natural killer cells and macrophages, anti-tumor warriors that battle solid cancers (Chemotherapy 1990;38:790-6; also International Conference on AIDS, Amsterdam, 1992). Effective And Safe In addition to lab tests, trials on people have shown that maitake may offer powerful therapy against liver and stomach cancer (studies in China), breast and colon cancer (US research) and Kaposi's Sarcoma, the virulent cancer attacking AIDS sufferers. Importantly, studies show that no side effects or interactions accompany maitake's efficacy. Maitake fortunately has won the interest and enthusiasm of the scientific community. Currently, researchers at the Cancer Treatment Centers of America, headed by Denis Miller, MD, are completing an exhaustive test of the anticancer and immunostimulatory actions of maitake on folks with advanced colorectal cancer. These investigators hypothesize that the polysaccharide beta-glucans derived from the fruitbody of maitake fight tumors and boost immune function. "Though it cannot be said that maitake ...[is] the cancer cure," said Dr. Nanba in his closing remarks at the Adjuvant Nutrition in Cancer Treatment Symposium in Tampa, Florida, in October 1995, "one can safely say that they do maintain the quality of life of patients and improve the immune system, resulting in the possible remission of cancer cells with no side effects." More Bodily Benefits Maitake maven Dr. Nanba also has tested-with strongly positive results-the effect of maitake on blood glucose, insulin and triglycerides in mice, whose levels of all three substances declined when they were fed the mushroom (H. Nanba working paper, Anti-Diabetic Activity by Maitake Mushroom, 1994). With colleagues, Dr. Nanba showed that maitake lowered blood pressure in hypertensive rats (Chem. Phann. Bu//36:1000-1006,1988). Other studies suggest it may accelerate weight loss. This admirable adaptogen (meaning it helps the body adapt to stress and normalize its functions) is water soluble and may be eaten in food or taken as a supplement. Vitamin C is believed to intensify maitake's beta-glucans and enhance their absorption. Tea Time It's not just what you eat that may help protect against cancer, but what you drink as well. Research from China and Japan, where tea is the everyday drink and rates of several cancers like breast and prostate are lower, may persuade you to turn over a new leaf in your own beverage choice. One of the first studies to spark interest in tea came from Shanghai (Journal of the National Cancer Institute, June 1, 1994), where people who drank two to three cups a day were found to have about a 60% reduction in the risk of cancer of the esophagus. The reason: tea leaves contain compounds called polyphenols, potent antioxidants. In fact, in tests at the University of Kansas, three of these, known as catechins, far outshone the common antioxidant vitamins C and E. Clinical trials are just starting, but early results are encouraging. A team of Chinese scientists reported that in a third of people with precancerous mouth sores who drank three cups of a mixture of green and black tea the lesions shrank significantly. Researchers at the Saitama Cancer Center in Japan found that green tea seems to improve the prognosis of breast cancer. They followed a group of women with early-stage tumors for seven years. Those who drank more than five cups of green tea a day were only half as likely to suffer a recurrence as patients who consumed fewer than four cups a day. Lung Help And at the University of Indiana, toxicologist James Klaunig found that the lungs of cigarette smokers who drank the equivalent of six cups of tea a day suffered 40 to 50 percent less damage from the toxins in smoke, potentially lowering their risk of lung cancer and other pulmonary problems. Simultaneously, research from Purdue University suggests tea's cancer-discouraging powers go beyond being an antioxidant. Scientists Dorothy and D. James Morre showed that a tea catechin dubbed EGCG inhibits a growth-promoting enzyme on the surface of many cancer cells-happily without affecting normal cells. And researchers at the Ohio State University College of Medicine found that EGCG counteracted another enzyme, urokinase, that helps cancer cells spread. To top it off, Mayo Clinic scientists recently showed that EGCG prompted prostate cancer cells to commit suicide (Cancer Letters, Aug. 14, 1998). Tea Research So far, most tea research has focused on green tea, and investigators agree it's more potent than the black tea most Americans favor. But because both kinds come from the same plant, Camellia sinensis (it's the processing that makes the difference as black tea is fermented, green tea isn't) both contain cancer-fighting polyphenols, just in different quantities. As long as the tea you drink (even decaffeinated) is fresh brewed, it's likely to provide some benefit; powdered and prepared teas probably don't. And adding milk may dilute the effect. Astragalus Against Tumors Astragalus, an herb commonly used in Asia to boost stamina, has impressed western doctors for its potential for helping people cope with chemotherapy. As John Diamon, MD, W. Lee Cowden, MD and Burton Goldberg point out in the Definitive Guide to Cancer (Future Medicine), "Astragalus appears to protect the liver against the harmful toxic effects of chemotherapy and may be effective in treating terminally ill liver cancer patients." (They cite a study in the Jrnl of Ethnopharmacology 1990, 30:145-149.) In addition, they point out, research in Japan supports using a ginseng-astragalus combination to improve the function of natural killer (NK) cells which can boost immunity (Japanese Jrnl of Allergy, 37:2, 1998, 107-114). Other studies confirm astragalus' potential in fighting off cancer. Research at the General Hospital of PLA, Beijing, showed that flavonoids (pigments) in astragalus could help protect cell membranes from oxidative damage caused by ultraviolet exposure (Chung Kuo Chung Yao Tsa Chih, 21(12):746-8; 1996 Dec). A study of laboratory animals at Cunma University in Maebashi, Japan, found that Astragalus could help preserve immune function against the harmful side effects of chemotherapy (Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 15(2):101-3, 1995 Feb). Garlic Benefits Like a flame attracting moths, garlic bulbs have irresistibly drawn the attention of medical researchers. A study at Aarhus University, Denmark, found that skin cells in laboratory dishes treated with garlic supplements lived longer, healthier lives than untreated cells (Jrnl Ethnopharm, 1994. 43:125-133). Meanwhile, a long list of research demonstrates that garlic's phytochemicals may fight tumors and reduce the carcinogenicity of the pollutants and chemicals that assault us daily. A study in China reported in the American Journal of Chinese Medicine showed that garlic helped slow tumors in lab animals (1983, 11:69-73). Another study in the Journal of Nutrition found that compounds in garlic could "suppress the growth of human colon tumor cells" (126, 1355-1361). Added to those benefits, Robert A. Nagourney, MD, reports in the Journal of Medicinal Food (1:1, 1998, 13-28), garlic may "modify the carcinogenicity of foodstuffs." In other words, studies show that garlic can make chemicals in foods like pork less likely to cause your cells to become cancerous. (Ind J Physiol Pharmacol, 39:347-353). DNA Protection DNA, the stuff that genes are made of, face constant threats from free radicals, caustic molecules that can alter cellular structure and possibly cause genetic mutations that lead to cancer. But research into what are called oligomeric proanthocyanidins (OPC), flavonoids (pigments) derived from fruits vegetables, grape seed extract and the bark of maritime pine trees shows that OPC may be able to shield DNA from injury. In particular, studies of a grape seed extract called Activin have demonstrated this substance can help liver cell DNA escape a destructive process called peroxidation (FASEB, 11:3, 2/28/97). In these experiments, Activin demonstrated the ability to inhibit the growth of tumor cells as well as slow the replication enzymes of HIV viruses. This protective ability proved to be more potent than that of vitamin C, beta carotene and vitamin E. Future Promise What does the future promise to reveal? Scientists believe that many unexamined plants probably contain undiscovered phytochemicals that hold great potential for helping us fight the cancer epidemic. Certainly, if the next few years produce as many results as the past decade, the next millennium will witness a long line of cancer-prevention discoveries. Before long, you should be able to take advantage of these potent substances. As you gulp your garlic, tip your tea cup, mull your maitake, acquire Activin and await your astragalus, you may meditate on what may soon be added to our growing anti-cancer arsenal. Undoubtedly, scientists with a botanical bent will be uncovering more coveted anti-cancer secrets before too long.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=326) Milk Thistle and Liver Damage abstract ...
Date:
May 22, 2005 04:32 PM
Silymarin Protects Against Liver Damage in BALB/c Mice Exposed to Fumonisin B1 Despite Increasing Accumulation of Free Sphingoid Bases
Quanren He, Jiyoung Kim, and Raghubir P. Sharma,1 Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602-7389 This study showed that silymarin prevented FB1-induced liver injury and the overexpressions of selected genes for TNF-superfamily and IFNg.FB1 increased free sphingoid bases in tissues via the inhibition of ceramide synthase (Merrill et al., 1993; Wang et al., 1991). Free sphingoid bases could mediate cell death following FB1 treatment (Schmelz et al., 339 SILYMARIN PROTECTS AGAINST FUMONISIN HEPATOTOXICITY TABLE 2 Activity of Serine Palmitoyltransferase (SPT) in Liver and Kidney of Mice Following FB1 Exposurea Treatment Hepatic SPT activity Renal SPT activity Control 186.2 6 21.4 325.4 63.5 FB1 267.5 24.6* 319.5 14.8 Silymarin 80.0 12.9*,# 220.3 19.4*,# Silymarin 1 FB1 71.0 15.6*,# 251.1 13.6 aActivity of SPT is expressed as pmol product/min. mg protein. Data are presented as mean SE. *p 5 0.05 compared to control; # p 5 0.05 compared to FB1 treatment. 1998; Tolleson et al., 1999). In contrast to its inhibitory effects on liver damage and selected gene induction, silymarin dramatically increased FB1-induced accumulation of free sphingoid bases. The FB1-induced alterations in mouse liver were similar to those reported previously employing similar protocols (Sharma et al., 1997, 2003a,b). The only difference in treatments was the duration (3 vs. 5 days in former reports) and gender (females in the current experiments). Exposure of mice to FB1 caused the appearance of apoptotic cells in liver with no other noticeable alterations. The PCNA-positive cells were also increased in FB1treated mice. In conclusion, we have clearly demonstrated that silymarin plays a protective role in FB1 hepatotoxicity in a mouse model. These findings suggest a therapeutic potential of silymarin in fumonisin liver injury in humans or animals exposed to fumo-nisin-producing, fungus-contaminated feeds. The efficacy of silymarin in the protection from liver damage after long-term exposure to the mycotoxin still needs to be studied.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=92) Garlic Compounds Modulate Macrophage and T-Lymphocyte Functions 
Date:
May 12, 2005 12:33 PM
Garlic Compounds Modulate Macrophage and T-Lymphocyte Functions
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