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Combine turmeric and black pepper to boost health benefits ofcurcumin Darrell Miller 5/14/19
8 Reasons to season your food with black pepper, the "King ofSpices" Darrell Miller 4/29/19
Did you know that turmeric is just as effective as 14pharmaceutical drugs? Darrell Miller 4/24/19
6 Spices That Can Help Reduce Inflammation Darrell Miller 3/15/19
Curcumin may protect the brain after a traumatic brain injury Darrell Miller 1/8/19
10 herbs to cure inflammation (and how to grow them yourself) Darrell Miller 1/6/19
Ten powerful anti-inflammatory herbs VitaNet, LLC Staff 8/30/18
Bioperine: Powerful Synergistic Compound Darrell Miller 5/29/17
Black pepper extract - Bioperine Darrell Miller 12/21/12
Does Green Coffee Bean Extract Help With Weight Loss? Darrell Miller 12/12/12
Bioperine Promotes Maximum Absorption Darrell Miller 2/6/12
What is Bioperine and How Does It Help with Absorption of Vitamins Darrell Miller 4/21/11
Green Tea Extract Darrell Miller 10/23/08
Increase Absorption Of Your Discount Vitamins With Bioperine Darrell Miller 11/2/07
Benefits - Supports joint function and tissue health* Darrell Miller 12/11/06
Degenerative joint disease (osteoarthritis) Darrell Miller 8/24/06
Naturally enhanced powers Darrell Miller 2/10/06
Curcumin - Turmeric Extract Darrell Miller 8/19/05




Combine turmeric and black pepper to boost health benefits ofcurcumin
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Date: May 14, 2019 04:08 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Combine turmeric and black pepper to boost health benefits ofcurcumin





Black pepper and turmeric turn out to provide complementary effects, with the piperine in black pepper making it easier for your body to absorb and use the curcumin in turmeric. Piperine helps protect curcumin from inflammatory processes long enough for the body to use it. Curry powder, which contains both turmeric and black pepper, is perhaps the most obvious way to get bother piperine and curcumin in your diet. However, if you truly hate the taste of turmeric, there are supplements available that have both black pepper and turmeric in them.

Key Takeaways:

  • Due to piperine that is contained in pepper that boosts the body’s ability to digest substances, it helps to take turmeric with black pepper.
  • Black pepper and turmeric have lots of similarities when it comes to the health benefits they provide and both are considered aromatic spices.
  • The yellow color of turmeric comes from the compound curcumin which it contains while the black color of black pepper comes from piperine.

"At the same time, it preserves turmeric from inflammatory processes that would normally break down the spice before it could be processed by the digestive system."

Read more: https://www.naturalnews.com/2019-03-31-combine-turmeric-and-black-pepper-to-boost-health-benefits-of-curcumin.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6315)


8 Reasons to season your food with black pepper, the "King ofSpices"
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Date: April 29, 2019 04:45 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 8 Reasons to season your food with black pepper, the "King ofSpices"





For hundreds of years, black pepper has been known as The King of Spices and for good reason. Black peppers has significant health benefits for most people. This powerful condiment supports healthy digestion and enhances overall cognitive function, possibly even preventing Alzheimer's Disease. Because of its thermogenic properties, it increases metabolism and can aid in weight loss. Due to its disinfectant properties, it supports oral health if massaged directly into the gums. And finally, because black pepper inhibits the proliferation of cancer cells, it may be a natural treatment for the disease.

Key Takeaways:

  • Black pepper eases human digestion, by aiding in the release of hydrochloric acid.
  • Data also suggests that black pepper is a friend to cognitive function, preventing neurodegeneration.
  • Black pepper may also prove a useful adjunct in the treatment of diabetes, respiratory ailment and gum disease.

"The piperine in black pepper lowers blood pressure by calcium channel blockade."

Read more: https://www.naturalnews.com/2019-03-06-reasons-to-season-your-food-with-black-pepper.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6215)


Did you know that turmeric is just as effective as 14pharmaceutical drugs?
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Date: April 24, 2019 01:46 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Did you know that turmeric is just as effective as 14pharmaceutical drugs?





Turmeric, a spice used in many Indian dishes, contains a high concentration of a substance called curcumin which possesses medical benefits rivaling many pharmaceuticals. Research suggests that turmeric has the potential to replace cholesterol and steroid medications, chemotherapy drugs, and antidepressants. There is even evidence it can be effective in reversing liver damage. Plant-based treatments are now in the process of revolutionizing modern medicine. In the near future, prescriptions for popular drugs such as Lipitor and Prozac could be replaced with prescriptions for Turmeric.

Key Takeaways:

  • Turmeric shows great health benefits that include fighting inflammation, diabetes, heart disease and even some cancers.
  • One current problem is that many over-the-counter turmeric supplements come from poorly-vetted Chinese suppliers and are contaminated with lead and other metals.
  • Turmeric holds promise as a complement to or replacement for a variety of antidepressants, anti inflammatory drugs, and other pharmaceuticals.

"Without a healthy fat/oil, curcumin may pass right through the body and not be absorbed into the small intestine and into the bloodstream, where it is most effective. Coconut oil, olive oil, and avocado are great to consume along with turmeric. Curcumin absorption is also boosted by piperine, the principle component found in black pepper."

Read more: https://www.naturalnews.com/2019-03-01-turmeric-is-just-as-effective-as-14-pharmaceutical-drugs.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6170)


6 Spices That Can Help Reduce Inflammation
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Date: March 15, 2019 10:32 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 6 Spices That Can Help Reduce Inflammation

Although inflammation can be painful to experience, it is the body's natural response to any form of injury or attack. Your body may be trying to protect you with these inflammatory responses, but the symptoms that come with it can be quite troublesome. Fortunately, research is now showing that there are certain spices that can help aid in the reduction of inflammation. Black pepper, for instance, can decrease the prominence of inflammation markers by its powerful piperine levels.

Key Takeaways:

  • Although inflammation is the body’s natural response to an attack from external agents, having prolonged inflammation is not a good sign.
  • Chilli peppers have anti-inflammatory properties and this is possible due to the presence of a compound in it called capsaicin.
  • No matter the dose at which it is taken, piperine that is found in black peppers can help one to fight inflammation.

"Turmeric is a yellow colored spice that originates from India and is added to curries and fresh vegetable juices. It can also be added to milk so that one’s immunity is strengthened. It contains a compound called curcumin. Curcumin is responsible for giving turmeric several of its health-benefiting qualities."

Read more: https://dailywellnesspro.com/6-spices-that-can-help-reduce-inflammation

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Curcumin may protect the brain after a traumatic brain injury
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Date: January 08, 2019 08:13 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin may protect the brain after a traumatic brain injury





Oxidative neurodegeneration is a process in which oxidative stress results in degeneration of the brain, often related to a traumatic brain injury (TBI). Studies are now showing that curcumin has protective abilities that can help decrease the brain's vulnerability to further injury as a result of oxidative stress. This could be due to several factors such as its anti-inflammatory properties, the way it increases antioxidants, and its natural healing properties that can aid in regeneration.

Key Takeaways:

  • Shockingly, traumatic brain injuries (TBI) affects several people in America. It is reported that they are sustained by about 2.8 million Americans every year.
  • It has been calculated that traumatic brain injury, TBI, is a cause of all injury-related deaths in America by about 30 percent.
  • Treatment for TBI which can include anything sufficient strong to cause brain injury to the head can include pain relief for mild cases, and ensuring adequate brain oxygen.

"When choosing a curcumin supplement, it is important to source one that is non-GMO, non-irradiated and preferably contains piperine (BioPerine) which enhances curcumin absorption by as much as 2,000 percent"

Read more: https://www.naturalnews.com/2018-12-26-curcumin-may-protect-the-brain-after-a-traumatic-brain-injury.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5940)


10 herbs to cure inflammation (and how to grow them yourself)
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Date: January 06, 2019 04:20 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 10 herbs to cure inflammation (and how to grow them yourself)





Dealing with chronic inflammation can lead to many troublesome symptoms such as joint stiffness and joint pain. Many natural herbs such as green tea and chili pepper have the ability to reduce inflammation, helping patients avoid these life-impacting symptoms. Green tea has been shown to not only help those suffering from arthritic pain, but it can also reduce the inflammation in the digestive tracts in those suffering from ulcerative colitis or Crohn's Disease. Chili peppers actually contain something called capsaicin which has been shown to reduce inflammation on its own.

Key Takeaways:

  • Green tea has been well researched and found to be effective against heart disease and cancer. It is also found effective against inflammation of the digestive tract.
  • Chilli pepper contains capsaicin which makes the pepper hot and also this compound has an anti-inflammatory effect in the human body.
  • Piperine is a compound in black pepper that gives it the distinctive flavor. This compound has been found to prevent cancer and suppress the perception of pain.

"Recent studies have shown that green tea can effectively treat inflammation, especially in the treatment of arthritis."

Read more: https://rekordnorth.co.za/136842/10-herbs-cure-inflammation-grow/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5936)


Ten powerful anti-inflammatory herbs
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Date: August 30, 2018 03:38 PM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Ten powerful anti-inflammatory herbs





Ten powerful anti-inflammatory herbs

Inflammation in the body is a condition which makes itself known in various clear ways. These include swelling, pain and a mobility loss in the region affected. For an intervention to be effective against inflammation, it would need to address all three of these specific areas, generally by affecting the immune system. Fortunately, there are herbs which do indeed address these particular effects of inflammation. Research has shown that there are specific elements in each of the following herbs that are useful for ameliorating inflammation pain and swelling, and thereby improving motility. These herbs include ginger, spirulina, black pepper and curcumin.

Key Takeaways:

  • Inflammation makes itself known in the body by exhibiting the symptoms of swelling, pain and a loss of mobility to the region.
  • Specific ingredients in natural substances, like piperine, found in black pepper, and gingerol, found in ginger, are anti-inflammatory agents.
  • Other substances with anti-inflammatory action include the herb, curcumin, and the blue-green algae, spirulina.

"To be successful in the management of inflammation with herbs, every attempt has to be made to identify and use herbs that not only deal with inflammation per se, but also those herbs that can take care of individual symptoms."

Read more: https://guardian.ng/features/health/ten-powerful-anti-inflammatory-herbs/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5734)


Bioperine: Powerful Synergistic Compound
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Date: May 29, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Bioperine: Powerful Synergistic Compound





Bioperine is an extract found in many pepper plants. It is related to the turmeric family. It has been tested in animals to possibly lower cancer rates in humans. It can also possibly boost your metabolism and encourage weight loss. It is easier to introduce in the market as a food rather than a pharmaceutical supplement. The product can also warm internal body levels and improve digestion which helps your body absorb more nutrients. Bioperine is a relatively safe product.

Key Takeaways:

  • standardized ingredients are important for supplements so that you receive the same results with each use.
  • Piperine has been shown to reduce weight by 20% and have strong anti-cancer actions in animal studies.
  • Adherence to quality is the most important quality to look for in a supplement because under the FDA's guidelines, one could simply use table pepper and sell it as piperine extract.

"This novel compound is one of several bio-active alkaloids found in these plants, and offers a slew of remarkable health benefits"

Read more: https://www.organicnewsroom.com/bioperine/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4724)


Black pepper extract - Bioperine
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Date: December 21, 2012 01:52 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Black pepper extract - Bioperine

Perhaps the biggest question that goes through our mind on the mention of the phrase black pepper extract is what the benefit of black pepper extracts is. piperine is the active ingredient of black pepper extract. Used together with other natural nutritional supplements, piperine not only enhances absorption but also bioavailability.

Going back to history, black pepper helped a great deal in shaping the development of the modern world medicine. Ayurvedic medicine that dates back to 6,000BC, used this extract to enhance digestibility. The internal heat generated by consumption of the pepper positively influences the ability of the body to absorb nutrients. As a matter of fact the one's nutritional status is not only dependent on what one eats but in his or her ability to absorb as well as transform nutrients into forms that are usable by the body. For maximum benefits it is important that Black pepper extract (piperine) is taken a couple of hours after meal.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2766)


Does Green Coffee Bean Extract Help With Weight Loss?
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Date: December 12, 2012 10:56 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Does Green Coffee Bean Extract Help With Weight Loss?

Green coffee beans

Green coffee beans are the seeds of a coffee plant that have not been roasted and usually have a high content of chlorogenic acid, which play a critical role in metabolic reactions in the body. It helps to break down fats, promote carbohydrate absorption, control the levels of blood sugar and also act as an antioxidant. Coffee beans are usually soaked and then concentrated to be able to get the green coffee extract. Clinical studies have shown that daily intake of about 400 mg of the coffee bean extract before taking breakfast allow one to lose one pound every week without altering the diet. This is explained by the ability of chlorogenic acid to burn out fat. A certain research also showed that taking 700mg of these extracts once a day enables one to lose weight daily. These clinical studies have been backed up by reviews from people who have used the green coffee extract. Chlorogenic acid is a plant polyphenol with a variety of antimicrobial properties and ability to suppress the absorption of glucose leading to weight loss. Roasted coffee beans usually have a very low chlorogenic acid concentration which breaks down during roasting of the beans.

Antioxidant properties

Researches have shown that this acid is a tumor inhibitor by nature, and it does this by preventing carcinogenic agents from integrating with DNA and resulting in cancer. It has been proven to prevent cardiovascular diseases, atherosclerosis, and type II diabetes. Most supplements of green coffee have piperine and green tea, and other contents that focus on burning fats. When buying green coffee extract, establish all the contents and the effect. One should not drink much coffee.  There is no need for coffee, one will get all the nutrients including a small amount of caffeine as an energy boost, so extra coffee might just amp you up to much.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2748)


Bioperine Promotes Maximum Absorption
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Date: February 06, 2012 06:19 PM
Author: Darrell Miller (support@vitanet.net)
Subject: Bioperine Promotes Maximum Absorption

Bioperine

Bioperine is an extract from black pepper that contains about 95 percent piperine. piperine is an alkaloid, the active substance that contributes to nutrients bioavailability and absorption. Bioperine can be combined with other specific nutrients to form different nutritional supplements that can be used for both animal and human consumption. Black pepper is mostly harvested before ripening, dried in the sun and then the extraction process begins.

How and why use of Bioperine promotes maximum vitamin absorption

Recent research has shown that the use of Bioperine, whose main constituent is piperine, increases thermogenic activity in the body. Thermogenesis is an accelerated metabolic process that takes place in the body cells in which conversion of glucose into energy takes place. An increase in absorption of discount minerals such as selenium and vitamins such as vitamin A has been witnessed to be triggered by the use of Bioperine. piperine works through initiating the release of catecholamines hormones that stimulate thermogenesis. However, the nutrients should presently available during this time since; the process takes place for a short duration.

piperine improves the necessary conditions of the intestines thus enhancing vitamins absorption. It alters the intestinal epithelial cell wall making it more permeable to vitamins and minerals. In addition, absorption of protein supplements such as those used by people who are on a dietary weight loss program is also increased. Several researchers have also shown that Bioperine has other benefits in the body, these includes the antibacterial properties and anti allergy properties.

Experiments prove that use of Bioperine increases vitamin and mineral absorption

Several studies on how much piperine promotes nutrients absorption have been carried out hitherto. For instance, an experiment was carried out on the effect of absorption of beta-carotene, vitamin B-6 and selenium which are fat soluble vitamin, water soluble vitamin and mineral in the form of selenomethionine respectively in the presence and absence of piperine. The experiment showed that absorption of these vitamins and mineral selenium increased appreciably when taken with Bioperine. There was 60 percent increase in absorption of beta-carotene and vitamin B-6 while 30 percent absorption was noticed for selenium. The experiment was carried out using 5 milligrams of Bioperine. Another experiment also showed a 30 to 200 percent increase in the absorption of Coenzyme Q-10.

Bioperine is the only piperine product to undergo comprehensive health tests and to be patented for the effect of increasing nutrients absorption, more so vitamins and minerals. By creating metabolic changes that require vitamins and minerals, Bioperine creates a nutritional need and then follows by increasing the nutrients bioavailability to meet the need. However, the process takes place in a short period. It is therefore advisable to co-administer minerals and vitamins with Bioperine so that they will be available during the right time for absorption. Unfortunately, research has shown that taking black pepper in its natural form does not yield the same results as those of taking Bioperine. This is mainly because the bioavailability of piperine is not that high in the natural form. Finally, antibacterial and anti allergy properties of Bioperine diversifies its application in medication.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2557)


What is Bioperine and How Does It Help with Absorption of Vitamins
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Date: April 21, 2011 03:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What is Bioperine and How Does It Help with Absorption of Vitamins

Get more from your food with Bioperine.

Bioperine is a patented form of an alkaloid found in black pepper. It is derived entirely from piperine, an organic compound responsible for the spicy taste of black pepper and long pepper. piperine has been noted for its thermogenic properties believed to speed up the absorption metabolism of digested foods. Recent studies have discovered that it also interferes with the release of enzymes that govern the bioavailability of drugs and supplements. By so doing, it enhances the rate of absorption of vitamins.

The human body has a complex mechanism of controlling the substances that get in and out of systemic circulation. The first pass occurs in the alimentary canal, where gastrointestinal enzymes break down substances into smaller compounds. It is believed that a very small percentage manages to undergo intestinal absorption after digestion. In general, this is the part where constituents of supplements remain undigested and instead enter the colon together with waste materials.

The liver plays a central role to the metabolism of drugs and most bioactive compounds. The compounds that pass the intestinal walls and enter the hepatic portal system, a group of veins that direct blood and other compounds from the gastrointestinal tract to the liver, is further metabolized inside the liver. Anything that the body considers foreign is sent to the kidneys and easily excreted through the urine. This is the reason why bioavailability is significantly reduced after ingestion.

Counteracts Effects of Enzymes

Bioperine is the only compound known to interact with enzymes that controls the metabolism of foreign materials within the intestinal epithelium. P-glycoprotein is released in the digestive tract to deal with drugs and xenobiotics found in our diet. Vitamins are no exception to the tightly regulated process of absorption in the intestines. These enzymes transport digested compounds to the liver.

It has been observed that piperine appears to reduce the expression of p-glycoprotein in the alimentary canal and other parts of the body. Proponents believe that bioperine, a purer form of piperine, is capable of counteracting the effects of the enzyme within the intestinal epithelium, making it easier for vitamins and supplements to enter the hepatic portal system.

Increases the Rate of Metabolism

Not all compounds that undergo the first-pass effect interact with the cells and tissues they are supposed to act on. If they should have an effect on any cell, they are still subjected to the actions of enzymes specialized for the expulsion of xenobiotics found in the systemic circulation and the rest of the body. For example, CYP3A4 removes foreign materials from the cells and facilitates their excretion.

Bioperine is touted to induce thermogenesis and stimulate cellular activities. By so doing, the effects of bioactive compounds are achieved while they remain inside the cells and tissues. The thermogenic properties of bioperine influence the rate of metabolism of digested compounds, including vitamins, minerals, and components of herbal preparations. Note that it can increase the update or prescription medications as well, so caution should be observed when consuming bioperine with medications.

If you want to give your body a nutrient boost, add bioperine to your supplement regiment to boost absorption.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2280)


Green Tea Extract
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Date: October 23, 2008 01:43 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Green Tea Extract



To understand the truth behind the medical claims for green tea and the antioxidant properties of EGCG, it is first necessary to have a close look at what green tea is, and why these claims are being made.

Green tea is a form of tea made from the leaves of the Carmellia Sinensis, a shrub that is native to China and has spread to other areas of Asia including Japan and the Middle East. Drinking it is believed to impart many health benefits, including the prevention of obesity, heart disease and some forms of cancer and it has been used in traditional Chinese medicine for over 400 years.

Tea is known to have been consumed in China for around 5,000 years, and used, not only in Chinese medicine, but also in that of Japan, Thailand and India for a number of ailments including regulating blood sugar, treating wounds and digestive problems. The drinking of green tea to benefit the heart and other vital organs is described in the Kissa Yojoki (Book of Tea), written in 1191 by Eisai, a Japanese Zen priest.

This two-part book talks about the various medicinal benefits of green tea, such as preventing fatigue, curing beriberi, quenching thirst, clearing the thoughts, maintaining health of the urinary tract and improving digestive problems. It also explains how to grow tea and how to prepare and use the leaves. The methods of treatment of various ailments and medical conditions are described in the second part of the book.

The active ingredients in green tea are catechins, polyphenols with strong anti-oxidant properties. Antioxidants are important components of your diet due to their effect on free radicals. These are small molecules, generally oxygenated, such the superoxide cation and hydrogen peroxide that are generated during normal metabolic processes and also ingested in pollutants such as traffic and factory fumes and insecticides. Free radicals are also formed by the effect of the ultra-violet component of sunlight on your skin and other tissues.

The effect of free radicals on your body can be devastating, and they not only destroy cell membranes but also oxidize such molecules as the low density lipids (LDL) that carry cholesterol around your bloodstream. This allows the LDLs to be absorbed by the white blood cells and then deposited as fatty plaques in the walls of your arteries. The end result is a thickening and hardening of the arteries that leads to a condition known as atherosclerosis, where the blood supply to the brain and heart muscle is restricted, which can in turn lead to strokes and heart disease.

Their effect on your cells is to cause cancer and premature aging, among others, and free radicals are also believed to play a part in conditions such as Alzheimer’s and Parkinson’s disease and also inflammatory diseases such as arthritis and diabetes. They can also cause damage to your DNA.

It is essential, therefore, that these free radicals are destroyed as quickly as they are generated, and that is what antioxidants do. You might be more familiar with the antioxidants Vitamins A, C and E, and phytochemicals such as flavonoids and carotenoids, but there are many substances available to you that are even more powerful such as the polyphenols found in green tea.

Epigallocatechin gallate (EGCG) is the most powerful of these with antioxidant properties at least twenty five times that of Vitamin E, and 100 times that of Vitamin C. EGCG comprises around 10-50% of the total catechin content of the tea and studies indicate that it likely helps to protect against DNA damage by free radicals, to protect against oxidation of LDL, provide protection against the damage of ultra-violet radiation and to protect you from the free radicals that are generated by smoking tobacco and general airborne pollution.

There are suggestions that the bioavailability of EGCG can be increased by consuming black pepper when drinking green tea, possibly due to the presence of piperine in the pepper. The piperine appears to retard the intestinal glucuronidation of EGCG and so allow more of it to be absorbed as opposed to excreted. So if you are using green tea for health reasons, spice up your food with a small amount of black pepper - that's all it needs. You don't have to smother your food in it! It should be stressed that these tests were carried out on animals, although the biochemistry involved is much the same.

The oxidation of fat by your metabolism to provide energy is a very important factor in weight control. If the contribution of the fats you ingest to the energy generated by your metabolism is low, then the fats can go on to be deposited in your body. This is not only unsightly, in that it can basically make you look 'fat', but is also dangerous to your health. Fat deposits around your midriff and round the major organs of your body can be extremely damaging and a severe risk to your health.

It has been shown by a recent study in the UK (Birmingham University) that those taking green tree extract displayed a 17% increase in fat oxidation over those given a placebo. Not only that, but the ratio of fat oxidation to the overall energy expenditure showed a similar differential between the study and the control group. This provides evidence of green tea extract being able to control your weight by burning fat, and also to improve the tolerance to glucose and sensitivity to insulin of healthy people.

Many other health claims have been made for green tea extract, although many of these have little, if any, scientific basis. Among these are the claims that it can treat multiple sclerosis and be used to treat cancer, although claims that it can prevent the destruction of cell membranes due to its oxidative effect are supported by the biochemistry, if not the medical proof. There are cases where theoretical biochemistry can explain many of the applications of ancient remedies without needing modern day studies to support it.

Some of the research supporting the green tea theories include:

1. In 2006, a study was announced that had followed over 40,500 Japanese men and women, aged between 40 and 79, that had no history of coronary heart disease, stroke or cancer starting in 1994. It was found that those who drank at least 5 cups of tea per day had a 16% lower risk of dying from any cause and a 26% less risk of dying from cardiovascular disease than those that drank less than one cup of tea each day. Since cardiovascular disease and cancer are the major causes of death world-wide, these are significant results.

2. Again in 2006, it was reported in the American Journal of Clinical Nutrition that studies indicated that a higher consumption of green tea was associated with a reduction in human mental impairment when compared to the average.

3. Yale University School of Medicine reported later that year that, in spite of smoking more than their western counterparts, Asians suffered lower rates of cancer and heart disease, and put that down to them drinking over 4 pints of green tea daily. It was the polyphenol content of green tea and its antioxidant effect that was proposed for this result, known commonly as the 'Asian paradox'. A specific reason given for this was the antioxidant effect preventing the oxidation of LDL cholesterol, and its subsequent deposition in the artery walls.

4. Another component of green tea is the amino acid L-Theanine that promotes relaxation, and it is believed that this could help to fight stress by inhibiting the excitation of cortical neurons.

There is a lot more evidence for the health benefits of green tea, and once again it appears that the ancients have been proved correct. Perhaps we should pay more attention to ancient remedies, although without the proper evidence much of it is ignored - for the time being at least. Green tea, however, has generally been accepted due to the research and studies carried out on ECGC (Epigallocatechin gallate) and in additional to the traditional form, is also available as a dietary supplement.



--
Vitanet ®, LLC

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Increase Absorption Of Your Discount Vitamins With Bioperine
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Date: November 02, 2007 04:54 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Increase Absorption Of Your Discount Vitamins With Bioperine

In order to understand how you increase absorption of your discount vitamins with Bioperine, it is necessary to understand the metabolic process of thermogenesis. First, however, let’s have a look at what Bioperine is and where it comes from.

Bioperine is obtained from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) of which it is a patented standardized extract. These peppers contain the alkaloid piperine, and the extract contains 95% piperine. The plants are grown in the ideal damp soil in regions of Southern India where the earth is rich in nutrients. The barriers are harvested just before ripening, and then dried in the hot sun before the extraction process is started. piperine has many uses from flavoring to fly killer, but people have been using it for centuries to heal wounds though this is apparently unconnected with the use to which the extract is put.

It has recently been found to help increase the absorption of a number of discount vitamins and minerals, including Vitamin B, beta-carotene, and selenium, by increasing the thermogenic activity of the body. Thermogenesis is one of the metabolic processes of the body that takes place within our cells whereby glucose is converted to energy, but at an accelerated metabolic rate. It is the rise in the metabolic rate that is referred to as thermogenesis.

When you eat food, or take supplements, the metabolism increases above the normal rate, the amount of increase depending upon the type on nutrient taken. Fats will increase your metabolism at a lower rate than proteins will, for example, since more energy is needed to break down proteins than for fats. Another substance that stimulates thermogenesis is piperine. It does so by utilizing the biochemistry of the body so that the chemicals needed for thermogenesis are made available.

piperine triggers the release of compounds known as catecholamines, hormones that in turn stimulate the thermogenetic process. However, this occurs over a short period of time, so the nutrients that are needed should be present in the gut as well since the window of absorption is very narrow. The substance also modifies the epithelial cell wall of the intestine to make it easier for the nutrients to be absorbed into the bloodstream, and it also gives amino acids a kick to get moving to the cells in which they are required.

Bioperine, then, not only sets off the metabolic changes that demand vitamins and other nutrients and enzymes, but also improves the conditions in your intestines so that these nutrients can more easily get to where they are needed. Basically, what Bioperine does is to cause the intestinal wall to become more permeable to nutrients, so that vitamins and drugs are not degraded when passing through the intestinal wall to the bloodstream. This improves digestion and absorption of minerals and vitamins, in addition to protein supplements frequently used in weight loss diets.

Bioperine starts by generating a need for nutrition and then increase the bioavailability of the nutrients provided to meet that need. However, due to the short window of absorption that piperine generates, the vitamins and minerals you want absorbed should be co-administered with the Bioperine so that they are in place ready to be absorbed at exactly the right time.

There have been several studies carried on the efficiency with which piperine achieves this. The absorption of three different types of nutrients has been measured with and without Bioperine. These were beta-carotene, a fat soluble vitamin, vitamin B-6, a water soluble vitamin, and also a mineral, selenium which was provided as selenomethionine. The absorption of these by the digestive system was measured by detecting them before and after in the blood, and were found to increase considerably when taken along with Bioperine, but not so with the control group without it.

Measured increases were a 60% increase in beta-carotene, similar to that of vitamin B-6, and was 30% in selenium. The tests used a 5 mg dose of the Bioperine. Other studies have indicated an increase in the absorption of Coenzyme Q-10 of between 30% - 200%. This is the only piperine based product that has been patented for its effect in increasing the absorption of nutrients into the body, and also the only piperine based product to undergo such tests in the U.S. to substantiate its claims and prove its safety for use.

The black pepper itself is a common household spice, and has been used in India for its medicinal properties for centuries. It is mentioned in the practice of Ayurveda and its concentration on the function of the digestive tract in human health. Many of its formulas contain black pepper amongst their ingredients. The bioavailability of nutrients is a significant factor in the health of any specific population, and the exponents of Ayurveda overcame this problem, by chance or design, six millennia ago. It has been demonstrated time and time again that diet is not the factor of importance in nutrition, but how much of that diet is absorbed through the intestines.

This is yet another example of the medicines of our ancestors being shown to have a solid scientific basis, and perhaps we should pay more attention to those others that are disregarded by modern science. It could be that we have only scratched the surface of understanding human metabolism and biochemistry, and that there is much left to learn. Ancient wisdom should never be disregarded.

Bioperine is also available in many supplement mixtures so that it is taken at the same time as the relevant vitamins and minerals. The recommended dosage is from 1 mg – 5 mg from 2 – 3 times daily. It takes around 2 – 5 mg of Bioperine to provide sufficient enhancement of absorption of the nutrients that are taken with it. Keep in mind that the nutrients are best taken at the same time, and that taking the extract itself will simple increase the absorption of any nutrients that are in the intestine at that time. Bioperine can be purchased at your local or internet vitamin store.



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Benefits - Supports joint function and tissue health*
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Date: December 11, 2006 03:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits - Supports joint function and tissue health*

To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.

Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3

Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3

Promotes optimal joint comfort, function and flexibility*

Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4

Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7

Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8

Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11

Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.

Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption*

Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14

Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.

Sustained Release – For lasting joint comfort and convenient dosing

To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.

Safety

Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.

Scientific References
1. Vidal y Plana, R.R., Bizzarri, D., Rovati, A.L. Articular cartilage pharmacology: I. In vitro studies on glucosamine and non-steroidal antiinflammatory drugs. Pharmacological Research Communications 1978; 10(6):557-569.

2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.

3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149.

4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.

5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.

6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002.

7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.

8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers.

9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46.

10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7.

11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.

12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34.

13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232.

14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J.

15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.



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Degenerative joint disease (osteoarthritis)
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Date: August 24, 2006 03:55 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Degenerative joint disease (osteoarthritis)

Degenerative joint disease (osteoarthritis) damages or destroys cartilage and its supportive collagen structure. As many as 40 million Americans, including the majority of people over age fifty, are thought to suffer from some form of this disease. Primary osteoarthritis, the “wear and tear” form, is due to normal use and age-related causes. Secondary osteoarthritis results from repeated joint trauma, inherited predisposition, or previous inflammatory conditions. While non-steroidal anti-inflammatory drugs (NSAIDs) treat symptoms only, a natural, holistic approach strives to improve the environment of the cartilage and joint as a whole by providing protective and restorative nourishment, increased circulation, decreased inflammation and reduced free radical damage.

High levels of Glucosamine and Chondroitin Sulfate

Widely regarded as the first defense in protecting joints, glucosamine and Chondroitin sulfate have been shown to effectively control joint pain and slow down or reverse the progression of cartilage deterioration. The integrity of joint gliding surfaces as well as the health of tendons, ligaments, joint fluids, skin, bones, heart valves and virtually all structural elements in the body is dependent upon the proper synthesis and availability of proteoglycans, integral components of joint cartilage.

Glucosamine provides two components critical to the synthesis of proteoglycans: hyaluronic acid and glycosaminoglycans (GAGs).

Chondroitin sulfate represents an important group of GAGs. It is not a single compound, but rather a class of compounds with different molecular weights that each have specialized functions within the body.

Numerous studies have shown that long-term safety, reduction in pain and protection of cartilage with body chondroitin and glucosamine are comparable or superior to results obtained with NSAIDs.

MSM. (Methylsulfonylmethane) MSM is a rich source of sulfur, a mineral required for GAG synthesis. A preliminary study suggests that MSM may help reduce pain in persons with degenerative arthritis.

Gota Kola. (Centella asiatica) known to support collagen synthesis and stimulate GAG’s, Gota Kola has been used for many years in Europe to promote wound healing and blood vessel integrity. It also has been shown to improve circulation in small vessels.

Turmeric. (Curcuma longa) this saffron-colored root offers a wide range of benefits. It naturally inhibits the inflammatory COX-2 enzyme, reduces pain and is a potent antioxidant that protects the liver and other cells. High antioxidant diets may inhibit joint deterioration.

Bromelain. Derived from pineapple cores, Bromelain is most commonly used for healing soft tissue injuries and inflammation. It contains potent selective proteases (protein-digesting enzymes) and other substances which serve to block destruction of GAGs.

Trace Minerals. Micronutrients play many distinct roles in support of healthy joint connective tissue and joint cartilage matrix.

Black Pepper Extract. Bioperine is a highly concentrated extract (95% - 98% piperine) of black pepper. Used as a bioavailability enhancer, it has been shown to increase the absorption of vitamins, minerals and herbs.



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Naturally enhanced powers
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Date: February 10, 2006 06:40 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Naturally enhanced powers

Curcumin is poorly absorbed in the GI tract, which limits its effectiveness. Fortunately, nature has an answer, in the form of piperine, a component of black pepper. piperine has been shown to increase Curcumin absorption by as much as 2000% when the two are consumed together. For this reason Doctors best has combined Curcumin with Bioperine, a patented black pepper extract that supplies 95%-98% piperine.

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Curcumin - Turmeric Extract
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Date: August 19, 2005 12:47 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Curcumin - Turmeric Extract

Curcumin

Turmeric- History and Traditional Usage

Native to Southeast Asia, Curcuma longa is a tall
tropical shrub with large oblong leaves and pale yellow flowers.
The genus “Curcuma” belongs to the Zingiberaceae family, which
includes ginger.1 The plant possesses a large root structure
with fleshy, bulbous underground parts called “rhizomes.” These
rhizomes, known as turmeric root, are harvested at maturity,
dried and cured for commercial use. Chemical analysis shows that
dried turmeric contains essential and volatile oils, with a
curcuminoid content of 2.5 to 5.0 %.2

In addition to its
popularity as a spice, turmeric is used as a dye for cloth and
coloring agent in foods and cosmetics, thanks to its rich yellow
color. Turmeric also serves as a preservative, probably owing to
the antioxidant and antimicrobial properties of curcumin.
Extracts of Curcuma longa have demonstrated in vitro
antibacterial and anti-fungal effects.3

Turmeric is named in
ancient Ayurvedic and Chinese herbal texts as a traditional folk
remedy. Historically, turmeric was used externally for wounds,
and sprains, and internally for digestive complaints,
rheumatism, liver disorders, coughs and colds.4
Benefits

Protects cells and tissues by fighting free radicals.*

Supports joint function*

The numerous beneficial
effects attributed to turmeric stem in large measure from the
antioxidant properties of curcumin. Antioxidants neutralize free
radicals, which are highly unstable molecules that can damage
cellular structures through abnormal oxidative reactions.
Curcumin is a potent “scavenger” of the superoxide radical, a
free radical that initiates potentially harmful oxidative
processes such as lipid peroxidation.5 Through this activity,
curcumin has been shown to protect skin cells from the injurious
effect of nitroblue tetrazolium, a toxin that generates
superoxide radicals. Curcumin also increases survival of cells
exposed in vitro to the enzyme hypoxanthine/xanthine oxidase,
which stimulates superoxide and hydrogen peroxide production.
Curcumin itself is not toxic to cells, even at high
concentrations. Pure curcumin was shown to be less protective
than a mixture of curcuminoids, indicating a possible synergism
among curcuminoids.6 Because free radicals are involved in aging
and exert harmful effects on skin, these results suggest
curcumin may help slow skin aging.

Curcumin demonstrates
several other in vitro effects linked to free radical
scavenging. Curcumin scavenges nitric oxide, a compound
associated with the body’s inflammatory response.7 Pure curcumin
and turmeric extracts protect red blood cells from lipid
peroxidation induced by hydrogen peroxide.8 Curcumin has been
shown to protect DNA from oxidative damage, inhibit binding of
toxic metabolites to DNA, and reduce DNA mutations in the Ames’
test.9 Although additional studies suggest an anticarcinogenic
effect of curcumin, through protection of DNA,10 one in vitro
study found that curcumin induced DNA damage in human gastric
mucosal cells.11 It is speculated that curcumin may act as a
pro-oxidant in the presence of transition metal ions such as
copper and iron. (This is true for other antioxidants, including
vitamin C.) Curcumin also demonstrates in vitro inhibition of
COX-I and COX-II enzymes, which are involved in the inflammatory
reaction.12 Together these results strongly suggest that
curcumin is a potent bioprotectant with a potentially wide range
of therapeutic applications.

Animal studies- In vivo protective effects

Through its free radical scavenging
properties, curcumin has shown bioprotective effects in animals.
In one study, rats were treated with isoproterenol, a chemical
that causes cardiac hypertrophy (enlargement of the heart) due
to abnormal collagen metabolism. Co-treatment with curcumin
reversed the degradation of collagen and cardiac hypertrophy
induced by isoproterenol.13 Curcumin protects mice from
detrimental effects of radiation, by stabilizing the glyoxalase
system, a biological system that regulates cell division.14
Curcumin protects livers of rats from the damaging effects of
carbon tetrachloride (CCl4), a potent hepatoxin that injures the
liver via its free radical metabolite, CCl3.15,16 Curcumin
protected rats from alcohol-induced brain damage, in a study in
which oral administration of curcumin reversed lipid
peroxidation, reduced levels of free-radical metabolites and
increased levels of glutathione, a major physiologic
antioxidant.17 Curcuma longa extracts have shown
anti-inflammatory effects in rats.18

Human Trials

Curcumin exhibits free-radical scavenging ability when
administered to humans. In an open trial (uncontrolled), 18
healthy individuals ranging in age from 27 to 67 years consumed
a Curcuma longa extract, at a dose supplying 20 mg curcuminoids,
for 45 days. Before and after blood tests showed a statistically
significant decrease in lipid peroxides.19 Preliminary trials
have tested the anti-inflammatory action of curcumin, with
results that verify the traditional use of turmeric as an
anti-rheumatic herb. In a short-term double-blind, cross-over,
comparative study, 18 people received curcumin (1200 mg daily)
or phenylbutazone for two week periods. Both curcumin and
phenylbutazone produced measurable improvements in joint
flexibility and walking time. The subjects reported results only
with phenylbutazone, which may be explained by the short
duration of the trial.20 In a small placebo-controlled trial
comparing curcumin to phenylbutazone, 45 patients with
post-operative inflammation received curcumin, phenylbutazone or
placebo. The anti-inflammatory effects of curcumin and
phenylbutazone were comparable and superior to placebo.21
Curcumin has not been found to produce an analgesic (pain
relieving) effect.

Bioperine-Nature’s Absorption Enhancer
Boosts Curcumin Absorption*

Traditional Ayurvedic herbal
formulas often include black pepper and long pepper as
synergistic herbs. The active ingredient in both black pepper
and long pepper is the alkaloid, piperine. Experiments carried
out to evaluate the scientific basis for the use of peppers have
shown that piperine significantly enhances bioavailability when
consumed with other substances.22 Several double-blind clinical
studies have confirmed that Bioperine® increases absorption of
nutrients.23

Curcumin is poorly absorbed in the intestinal
tract, limiting its therapeutic effectiveness. Oral doses are
largely excreted in feces, and only trace amounts appear in the
blood. Concomitant administration of 20 mg of piperine with 2
grams of curcumin increases the bioavailability of curcumin by
2000%.24

Scientific References


1. Majeed, M., Badmaev,
V., Shivakumar, U., Rajendran, R. Curcuminoids. 1995.
Piscataway, NJ: NutriScience Publishers.
2. Srimal, R.C.
Turmeric: a brief review of its medicinal properties.
Fitoterapia 1997;68(6):483-93.
3. Ammon, H.P.T., Wahl, M.A.
Pharmacology of Curcuma longa. Planta Medica 1991;57:1-7.
4.
Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae).
The Protocol Journal of Botanical Medicine, Autumn
1995:43-46.
5. Rao, N.S., Rao, M.N.A. Free radical scavenging
activity of curcuminoids. Arzneim.-Forsch./Drug Res.
1996;46(2):169-171.
6. Bonté. F. et al. Protective effect of
curcuminoids on epidermal skin cells under free oxygen radical
stress. Planta Medica 1997;63:265-66.
7. Rao, S., Rao, M.N.A.
Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol.
1997;49:105-7.
8. Lalitha, S., Selvam, R. Prevention of
H2Os-induced red blood cell lipid peroxidation by aqueous
extracted turmeric. Asia Pacific J Clin Nutr
1999;8(2):113-14.
9. Deshpande, S.S., Maru, G.B. Effects of
curcumin on the formation of benzo[a]pyrene derived DNA adducts
in vitro. Cancer Letters 1995;96:71-80.
10. Subramanian, M., et
al. Diminution of singlet oxygen-induced DNA damage by curcumin
and related antioxidants. Mutation Research
1994;311:249-55.
11. Blasiak, J., Trzeciak, A., Kowalik, J.
Curcumin damages DNA in human gastric mucosa cells and
lymphocytes. Journal of Environmental Pathology, Toxicology and
Oncology 1999;18(4):271-76.
12. Ramsewak, R.S., DeWitt, D.L.,
Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory
activities of Curcumins I-III from Curcuma longa. Phytomedicine
2000;7(4):303-308.
13. Nirmala, C. Anand, S., Puvanakrishnan,
R. Curcumin treatment modulates collagen metabolism in
isoproterenol induced myocardial necrosis in rats. Molecular and
Cellular Biochemistry 1999;197:31-37.
14. Choudhary, D.,
Chandra, D. Kale, R.K. Modulation of radioresponse of glyoxalase
system by curcumin. Journal of Ethnopharmacology
1999;64:1-7.
15. Park, E-J. et al. Protective effect of
curcumin in rat liver injury induced by carbon tetrachloride. J
Pharm. Pharmacol. 2000;52:437-40.
16. Deshpande, U.R. et al.
Protective effect of turmeric (Curcuma longa L.) extract on
carbon tetrachloride-induced liver damage in rats. Indian
Journal of Experimental Biology 1998;36:573-77.
17.
Rajakrishnan, V. et al. Neuroprotective role of curcumin from
Curcuma longa on ethanol-induced brain damage. Phytotherapy
Research 1999;13:571-74.
18. Arora, R.B. Basu, N., Kapoor, V.,
Jain, A.P. Anti-inflammatory studies on Curcuma longa
(Turmeric). Indian J Med Res 1971;59(8):1289-95.
19.
Ramirez-Bosca, A. et al. Antioxidant curcuma extracts decrease
the blood peroxide levels of human subjects. Age
1995;18:167-69.
20. Deodhar, S.D., Sethi, R. Srimal. R.C.
Preliminary study on antirheumatic activity of curcumin
(diferoyl methane). Indian J Med Res 1980;71:632-34.
21.
Satoskar, R.R., Shah, S J. Shenoy, S.G. Evaluation of
anti-inflammatory property of curcumin (diferoyl methane) in
patients with postoperative inflammation. International Journal
of Clinical Pharmacology, Therapy and Toxicolgy
1986;24(12):651-54.
22. Atal, C., Zutshi, U., Rao, P.
Scientific evidence on the role of Ayurvedic herbals on
bioavailability of drugs. Journal of Ethnopharmacology
1981;4:229-232.
23. Bioperine®–Nature's Bioavailability
Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa
Corporation, Piscataway, N.J.
24. Shoba, G., et al. Influence
of piperine on the pharmacokinetics of curcumin in animals and
human volunteers. Planta Medica 1998;64(4):353-6.

© 2002
Doctor's Best, Inc. Revised 8/13/02

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



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