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	The Role of Vitamins in Mental Health	Darrell Miller	5/31/24
	The Role of Vitamin B12 in Energy Production	Darrell Miller	5/29/24
	The Importance of Vitamin B-12	Darrell Miller	11/5/22
	What Are The Health Benefits Of Vitamin B12?	VitaNet, LLC Staff	8/28/18
	Aging without disease: Scientists have discovered that nervous system function can be restored with proper lifestyle adjustments	Darrell Miller	12/8/17
	If You Feel Tired All The Time, You Really Need To Read This	Darrell Miller	12/16/16
	Brain 'fat' key to mental health	Darrell Miller	11/20/16
	Lion's Mane Mushroom; The Ultimate Natural Memory Enhancer	Darrell Miller	10/7/16
	Peruvian Maca	Darrell Miller	9/17/14
	What Is Solaray Phosphatidyl Serine?	Darrell Miller	1/4/13
	Is Cod Liver Oil Good for My Health?	Darrell Miller	7/30/11
	Can Vitamin B12 Boost Mental Alertness?	Darrell Miller	7/18/11
	Can Vitamin B12 Boost Mental Alertness, Improve Stress Tolerance And Circulation?	Darrell Miller	6/28/11
	Folic Acid	Darrell Miller	8/19/08
	Essential Fatty Acids	Darrell Miller	7/24/08
	Lipid content by percentage	Darrell Miller	5/13/08
	Shark Cartilage	Darrell Miller	4/30/08
	Revita	Darrell Miller	3/8/07
	Which Calcium is Best?	Darrell Miller	10/17/06
	SAMe (S-Adenosylmethionine)	Darrell Miller	12/17/05
	Promilin Fenugreek Extract - Supports Healthy Blood Sugar Levels	Darrell Miller	6/28/05
	Benefits and Functions of Essential Fatty Acids	Darrell Miller	6/25/05
	Winter Survival Kit	Darrell Miller	6/13/05
	Thanks for the Memory	Darrell Miller	6/11/05
	R-Lipoic Acid - Fulfilling the Potential of Lipoic Acid	Darrell Miller	6/4/05
	MYELIN SHEATH SUPPORT™ - Herbal-Nutrient Nervous System Support!	Darrell Miller	6/4/05
	Mental Edge - Support proper Brain Function...	Darrell Miller	6/3/05
	Mega Mind - re-align your body systems ...	Darrell Miller	6/3/05
	Higher Mind - Smart Nutrients for the Performance of a Lifetime...	Darrell Miller	6/2/05
	Under-Reported (and Underappreciated) Cholesterol control.	Darrell Miller	5/12/05

Date: May 31, 2024 03:29 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Role of Vitamins in Mental Health

The Role of Vitamins in Mental Health

With growing awareness of mental health issues, research is increasingly highlighting the connection between vitamins and cognitive function. In recent years, studies have shown that vitamins like B12, D, and Omega-3 fatty acids play a critical role in mental well-being. This article delves into the latest findings and explores how these essential nutrients contribute to a healthier mind.

Vitamin B12: The Brain's Energy Booster

Vitamin B12, also known as cobalamin, is crucial for maintaining the health of nerve cells and red blood cells. It is found naturally in animal products, such as meat, fish, and dairy. Deficiency in this vitamin can lead to symptoms such as fatigue, memory loss, and even depression.

Latest Research on B12 and Mental Health

Several studies have examined the link between B12 and mental health. A study published in the American Journal of Psychiatry found that individuals with lower levels of B12 had a higher risk of depression. Similarly, research from the Journal of Neuropsychiatry revealed that elderly patients with B12 deficiencies exhibited more cognitive decline than those with sufficient levels.

How B12 Supports Cognitive Function

B12 plays a vital role in producing neurotransmitters, the chemicals that transmit messages between nerve cells. It also helps in maintaining the myelin sheath, a protective layer around nerves that ensures the swift transmission of neural signals. By supporting these functions, B12 contributes to maintaining cognitive clarity and emotional balance.

Vitamin D: The Sunshine Vitamin

Often referred to as the "sunshine vitamin," Vitamin D is synthesized in the skin upon exposure to sunlight. It can also be obtained from food sources such as fatty fish, fortified dairy products, and eggs. Vitamin D is essential for bone health, but its role in mental health is equally significant.

Latest Research on Vitamin D and Mental Health

A growing body of research has linked Vitamin D deficiency to mental health issues. A meta-analysis published in the Journal of Affective Disorders concluded that individuals with low levels of Vitamin D had a higher incidence of depression. Another study from The Lancet Psychiatry suggested that Vitamin D supplementation improved mood in patients with depression.

How Vitamin D Supports Cognitive Function

Vitamin D receptors are present throughout the brain, indicating that it plays a role in brain function. It helps modulate the release of neurotransmitters like serotonin and dopamine, which are critical for mood regulation. Adequate levels of Vitamin D can therefore help in maintaining a balanced mood and reducing the risk of mental health disorders.

Omega-3 Fatty Acids: The Mind's Nourishment

Omega-3 fatty acids are essential fats predominantly found in fish such as salmon, mackerel, and sardines. These fats are crucial for brain health and have been the focus of numerous studies investigating their impact on mental well-being.

Latest Research on Omega-3 and Mental Health

Various studies have highlighted the benefits of Omega-3 fatty acids for mental health. A study in the Journal of Clinical Psychiatry reported that Omega-3 supplementation significantly reduced symptoms of anxiety. Similarly, research from the American Journal of Psychiatry found that individuals with higher Omega-3 levels experienced fewer depressive symptoms.

How Omega-3 Supports Cognitive Function

Omega-3 fatty acids are integral components of cell membranes in the brain. They play a role in neuroplasticity, the brain's ability to form new neural connections. Additionally, Omega-3s help reduce inflammation, which has been linked to mental health disorders. By supporting these processes, Omega-3 fatty acids contribute to robust cognitive function and emotional stability.

Combining Vitamin Intake for Optimal Mental Health

While each vitamin individually supports cognitive function, combining them can enhance their benefits. For instance, a study in the Nutrition Journal found that a combination of Vitamin B12, Vitamin D, and Omega-3 supplementation improved cognitive performance in older adults more effectively than any single nutrient alone.

Practical Steps for Ensuring Adequate Vitamin Intake

1. Dietary Choices: Incorporate a variety of nutrient-rich foods into your diet. Include sources of B12 like meat, fish, and dairy; sources of Vitamin D like fatty fish and fortified products; and sources of Omega-3s like fish and flaxseed.
2. Supplements: Consider taking supplements if obtaining these vitamins through diet alone proves challenging. VitaNet LLC Carries Vitamin B12, Vitamin D3, and Omega-3 along with a large selection of other products.
3. Sun Exposure: Ensure regular, safe exposure to sunlight to boost Vitamin D levels naturally. Aim for about 15-20 minutes of sunlight several times a week.

Knowledge is Power

Understanding the role of vitamins in mental health underscores the importance of a balanced diet and adequate nutrient intake. Vitamins B12, D, and Omega-3 fatty acids each offer unique benefits that collectively contribute to improved cognitive function and emotional well-being. As research continues to unfold, it becomes increasingly clear that focusing on these essential nutrients is a crucial step toward achieving optimal mental health.

In summary, while mental health is influenced by a myriad of factors, ensuring adequate intake of key vitamins can provide a foundation for better cognitive and emotional outcomes. By adopting healthy dietary habits and considering supplementation when necessary, individuals can take proactive steps to support their mental well-being.

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Date: May 29, 2024 11:28 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Role of Vitamin B12 in Energy Production

The Role of Vitamin B12 in Energy Production

Vitamin B12, or cobalamin, is crucial for red blood cell production, DNA synthesis, and nervous system health. Among its many roles, one of the most vital is its contribution to energy production and metabolism. This article delves into how Vitamin B12 affects energy levels, with a particular focus on its importance for vegetarians and vegans.

Understanding Vitamin B12

Vitamin B12 is a water-soluble vitamin that is naturally found in animal products such as meat, dairy, and eggs. It is primarily responsible for converting food into ATP (adenosine triphosphate), which the body uses for energy. B12 is also crucial in the formation of red blood cells, which carry oxygen to every part of the body, and in maintaining the health of nerve cells.

The Science Behind Energy Production

Role in Metabolism

Vitamin B12 is a key player in metabolism, a complex set of chemical reactions in our body that convert food into energy. One of the primary ways B12 contributes to metabolism is through its involvement in the Krebs cycle, a series of reactions that produce ATP (adenosine triphosphate), the body's primary energy currency. During the Krebs cycle, Vitamin B12 helps convert fats and proteins into energy, ensuring that the body has a constant supply of fuel to perform everyday tasks.

DNA Synthesis and Cell Division

Vitamin B12 is also essential for DNA synthesis and cell division. It works closely with folate (Vitamin B9) to synthesize DNA during cell division. Rapidly dividing tissues, such as red blood cells, require an adequate supply of B12. A deficiency in this vitamin can lead to megaloblastic anemia, a condition where red blood cells are larger than normal and not as effective in transporting oxygen, thereby causing fatigue and weakness.

The Challenge for Vegetarians and Vegans

B12 Sources

One of the significant challenges for vegetarians and vegans is getting enough Vitamin B12, as it is predominantly found in animal products. Plant-based diets generally lack this vitamin, putting individuals at risk of deficiency. However, several fortified foods and supplements can help prevent this deficiency.

Fortified Foods and Supplements

Many plant-based milk alternatives, breakfast cereals, and nutritional yeasts are now fortified with Vitamin B12. For instance, a cup of fortified soy milk can provide about 50% of the daily recommended intake of B12. Additionally, B12 supplements are readily available and can be an effective way for vegetarians and vegans to ensure they get their daily dose. It's crucial to choose a supplement that meets the dietary needs and preferences of the individual.

Symptoms of Deficiency

A lack of Vitamin B12 can result in various health problems like fatigue, weakness, constipation, loss of appetite, and weight loss. In severe cases, it may lead to neurological issues such as numbness and tingling in the hands and feet, balance difficulties, depression, confusion, and memory loss. Given these risks, it's essential for vegetarians and vegans to monitor their B12 levels.

Benefits of Adequate B12 Intake

Enhanced Energy Levels

Adequate intake of Vitamin B12 can significantly enhance energy levels. Since B12 is involved in converting food into ATP, sufficient levels of this vitamin can help ensure that the body efficiently produces and uses energy. Individuals who maintain appropriate B12 levels often report feeling more energetic and less fatigued.

Improved Metabolic Function

By ensuring a sufficient supply of B12, vegetarians and vegans can support their metabolic functions. A well-functioning metabolism is crucial for maintaining body weight, supporting muscle function, and ensuring overall vitality. Improved metabolic function also means better handling of the foods consumed, leading to more stable energy levels throughout the day.

Better Mental Health

Vitamin B12 is essential for producing neurotransmitters that regulate mood. Adequate levels of B12 can help prevent mental health issues such as depression and brain fog, which are often associated with fatigue and low energy levels. Regular intake of B12, either through diet or supplements, can contribute to better mental clarity and emotional well-being.

Optimal Nervous System Function

B12 is crucial in maintaining the myelin sheath, a protective coating around nerves. A healthy nervous system ensures that signals travel efficiently between the brain and the rest of the body. This not only helps in preventing neurological issues but also ensures that the body's energy systems operate smoothly.

How to Ensure Adequate B12 Intake

Regular Blood Tests

For vegetarians and vegans, regular blood tests are an effective way to monitor B12 levels. These tests can help identify a deficiency early on, allowing individuals to take corrective measures before any severe symptoms manifest.

Balanced Diet

A well-rounded, balanced diet that includes fortified foods can help meet the daily recommended intake of Vitamin B12. Incorporating a variety of B12-fortified foods into every meal ensures a steady supply of this vital nutrient.

Considering Supplements

For those who struggle to get enough Vitamin B12 through diet alone, supplements are an excellent option.

Choosing the Right Supplement: Methyl B12

When selecting a Vitamin B12 supplement, methylcobalamin, or methyl B12, is often recommended as the best form. It has superior bioavailability compared to cyanocobalamin, making it easier for the body to absorb and utilize. Methyl B12 doesn't need conversion in the body to be effective, leading to quicker uptake and immediate benefits.

For vegetarians and vegans at higher risk of B12 deficiency, methyl B12 is especially beneficial for maintaining optimal B12 levels effectively. Including this form in your supplement routine can boost energy, mental clarity, and support metabolic and nervous system functions.

Awareness and Education

Raising awareness about B12 is key for vegetarians and vegans to prevent deficiencies. Health programs can educate on maintaining adequate levels through diet and supplements.

Are You Ready For More Energy?

Vitamin B12's role in energy production and metabolism is indisputable. Vegetarians and vegans can struggle to get enough B12 from plant-based diets, but fortified foods and supplements offer solutions. Understanding B12's importance and taking action can boost energy, metabolism, and well-being. Regular monitoring, a balanced diet, and appropriate supplementation are key strategies to prevent deficiency and maintain optimal health.

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Date: November 05, 2022 10:41 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The Importance of Vitamin B-12

Vitamin B-12 is an essential nutrient that is involved in energy production, brain and nerve health, DNA replication, red blood cell production, and myelin sheath formation. While you can get vitamin B-12 from eating certain foods, many people don't get enough of this important nutrient and may need to supplement with a vitamin B-12 supplement like Source Naturals Vitamin B-12 Sublingual 2000 mcg.

Vitamin B-12 is an important nutrient for many reasons. This water-soluble vitamin helps to convert carbohydrates into glucose, which is used for energy production in the body. It also helps to form red blood cells and helps with the absorption of iron. Iron is important for carrying oxygen in the blood. Vitamin B-12 is also necessary for proper DNA replication and for the formation of the myelin sheath, which is a layer of insulation around nerve cells.

Vitamin B-12 deficiencies are common, especially among older adults, vegetarians, and vegans. Symptoms of a vitamin B-12 deficiency include fatigue, weakness, memory loss, depression, and nerve problems like numbness or tingling in the hands and feet. If you think you may be deficient in vitamin B-12, talk to your doctor about getting a blood test. A simple blood test can tell you if you are deficient in vitamin B-12 and whether or not you need to supplement with a vitamin B-12 supplement.

In Summary:

Vitamin B-12 is an essential nutrient that plays a role in energy production, brain and nerve function, DNA replication, red blood cell production, and myelin sheath formation.

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Date: August 28, 2018 09:53 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: What Are The Health Benefits Of Vitamin B12?

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Date: December 08, 2017 03:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Aging without disease: Scientists have discovered that nervous system function can be restored with proper lifestyle adjustments

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Date: December 16, 2016 02:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: If You Feel Tired All The Time, You Really Need To Read This

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Date: November 20, 2016 03:04 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Brain 'fat' key to mental health

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Date: October 07, 2016 03:43 PM
Author: Darrell Miller
Subject: Lion's Mane Mushroom; The Ultimate Natural Memory Enhancer

Lion’s Mane Mushroom (Hericium erinaceus) also bearded tooth mushroom, bearded hedgehog mushroom, or satyr's beard is an edible and medicinal mushroom indigenous to Europe, Asia, and North America.

Lion’s Mane for neuroprotection, brain function, and enhanced memory

Nootropic effect is perhaps the biggest draw of Lion’s Mane mushroom. Scientifically, the mushroom has been proven to have neuroprotective abilities as well as boost cognitive function such as enhancing memory. It’s also associated with the manufacture of Nerve Growth Factor (NGF) which is a natural antidepressant. All these gives it the ability to help in maintaining attention and focus. It's therefore, a natural supplement for general brain function.

Other health benefits

Digestion aid - Lion’s mane contains glucan polysaccharides which improve stomach mucosa functioning that enhances digestion as well as protect the skin against aging. In addition, it contains cythan that aide in the treatment of esophagus cancer and peptic ulcers.

Enhances Immune System – the mushroom is rich in antioxidants, polysaccharides, beta-glucan and beta-glucoxylan that strengthens the immune system, by exhibiting immune-modulating features that decrease arthritis.

Lowers High Cholesterol – research carried on an animal indicated that the mushroom reduced 45% bad cholesterol and added 31% good cholesterol making it a substantial ingredient in cholesterol-free diets.

Myelin sheaths Repairs- Lion’s mane does not show any toxicity when consumed. It also enhances myelin sheath growth. This explains why it’s used to treat multiple sclerosis and other conditions related to the central nervous system.

Lion's Main is a great supplement for older individuals looking to improve mental function.

Reference URLs

https://www.healthbenefitstimes.com/health-benefits-of-lions-mane-mushroom/

https://en.wikipedia.org/wiki/Hericium_erinaceus

//www.huffingtonpost.com/paul-stamets/mushroom-memory_b_1725583.html

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Date: September 17, 2014 05:25 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Peruvian Maca

What is a Maca Root?

Maca Root is one of the roots and tuber harvests of higher protein content. Until late years, this nutritious base of the Andes was little or nothing known for the lion's share of the individuals thereof, Peru (aside from the tenants of the Andes) and obviously overlooked by whatever is left of the world.

Maca (otherwise called Peruvian Maca or Maca Andina) has an astonishing quality to develop to remarkable statures: from 3800 to 4800 meters high in the most cold Andes mountains, where temperatures are amazing, from exceptional hotness morning to ice on the night, frigid winds, snow and persevering high power of daylight. In this antagonistic region, where there is little oxygen, there is uncommon vegetation develop just potatoes and maca sharp. There are no trees, no plants, just a couple of centimeters tall.

This tuber, irrelevant part of the tuberous root size and state of a typical radish, is effectively dried under the sun and keeps up its nutritious qualities, with elevated amounts of iron, for a few years stockpiling. It is brilliant nourishment and Incas additionally utilized it for its richness improving activity and its impact on sexual conduct.

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Date: January 04, 2013 01:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Is Solaray Phosphatidyl Serine?

Phosphatidyl Serine : What are its Health Benefits?

Phosphatidyl serine is a popular medication for people who need to improve their memory and mental well-being. Not only does it work to improve your memory, it also has other health benefits to your body.

What is Phosphatidyl serine?

Each cell in your body has a membrane that protects its internal contents from the surrounding environment as well as control what enters the cell and what goes out. This serine is one of four major phospholipids that make up part of this membrane. This lipid is found in high concentrations in the cell membrane that surrounds the hippocampus of the brain, which is associated with your memory.

How does Phosphatidyl serine supplementation benefit you?

As you age, the cells around the hippocampus also lose their potential to fully function. This makes your mental processes to slow down. Providing your body with this serine will provide material necessary to rejuvenate the cell membrane, thus improving your memory. This compound is useful in stressful situations. Some situations need you to concentrate on what you are doing and yet you may be tired.

For example, you may face an exam which needs you to be at full concentration and be alert at all times. This serine helps boost your memory and concentration, which in turn increases your focus thus improve learning. When you get stressed, your body releases cortisol which damages the tissues of the hypothalamus in your brain. To reduce the effects of this hormone, you need Phosphatidyl serine to repair the tissues that have been damaged. This helps you to retain your memory after a stressful situation.

For your body to function properly, the cell membrane surrounding various organs has to be in good health. Phosphatidyl serine will work to improve the health of various membranes, such as myelin sheaths found in the central nervous system. The compound is found in small amounts in foods such as liver and soy, therefore it is advisable to use supplements which provide a high level of the compound.

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Date: July 30, 2011 01:19 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Is Cod Liver Oil Good for My Health?

Cod liver oil is a dietary supplement obtained from the liver of a group of fishes collectively known as cod. It is an all natural remedy for a diverse variety of disorders, and as such remains one of the most popular supplements to this day. Recent studies have confirmed many of its age-old health claims. It is now common knowledge that it aids joint health, treats skin conditions, and improves brain function.

Deactivates Pain Chemicals

The nutrient profile of cod liver oil makes it an excellent source of eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA. These omega 3 fatty acids have long been identified by scientists as anti-inflammatory compounds. Numerous studies have documented that they exert an inhibitory effect on chemicals that sensitize tissues to pain, cause excessive inflammation, and bring on rheumatism.

Nourishes Joint Cartilage

Cod liver oil is a traditional treatment for joint pain characteristic of arthritis. In recent years, it has been noted as the leading therapeutic remedy for rheumatoid arthritis and osteoarthritis. Research has shown that it is capable of switching off enzymatic processes responsible for the destruction of cartilage tissue in arthritis. Also, its fatty acid content nourishes the proteins found in joint cartilage.

Protects Nervous Tissue

The myelin sheaths that insulate the axons of nerve cells located in the brain and spinal cord require fatty acids to support their physiological functions. In particular, DHA is the principal fatty acid that nourishes nervous tissue. Cod liver oil has been utilized as an adjunct medication for multiple sclerosis in studies, and reports suggest its potential as a mainstay of treatment for other neurological disorders.

Enhances Brain Function

In addition to their known role in the upkeep of myelin sheaths, fatty acids are directly involved in the development of brain function. In fact, they are a major component of breast milk. For years, nutrition experts have suggested consumptions of cod liver oil to combat neurodegenerative disorders as well as enhance cognitive capacities as it contains high levels of compounds proven as effective nootropics.

Alleviates Skin Conditions

The nutrient profile of cod liver oil is particularly good for the skin. Apart from the fact that it counters inflammatory agents that cause hypersensitive skin conditions, such as eczema and psoriasis, it also promotes tensile strength and maintains skin elasticity. Cod liver oil is a good source of omega 3 fatty acids, essential fatty acids, vitamin A, vitamin, D, and vitamin E, all of which contribute to skin health.

Prevents Heart Disease

Cod liver oil maintains heart health and even reverses cardiovascular disorders. Medical professionals have supported this nutritional supplement as it has been clinically proven to cut the risk of heart disease. It alters the profile of lipids present in the blood and appears to reduce cholesterol. For decades, lower incidence of cardiovascular disorders has been tied to populations that consume high amounts of cod.

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Date: July 18, 2011 12:01 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Vitamin B12 Boost Mental Alertness?

The body needs various nutrients in order to make vital biological reactions possible. These bodily reactions are necessary for energy production, immune system enhancement and health improvement. These nutrients are classified into two, macro and micronutrients. In addition, these micronutrients are further divided into vitamins and minerals. These vitamins are needed by individuals to help the body grow normally. Vitamins can be supplied by the food we eat. However, the body can make certain vitamins such as vitamin D and K. Individuals who are in strict vegetable diet usually need vitamin B12 supplement. In this article, we will be focusing on Vitamin B 12 or also known as cyanocobalamin.

Vitamin B 12 is also a water– soluble vitamin. It is considered as essential because it is not produced by the body. Excellent sources of this vitamin include fish, shellfish, meat, milk and milk products. Vitamin B 12 is also available in supplements in combination with other vitamin B complex. Like the other B vitamins, vitamin B 12 is also necessary in maintaining healthy brain cells and in the normal production of red blood cells. Riboflavin is also a component of DNA which is the cells’ genetic material. Vitamin B 12 in the stomach combines with a substance called intrinsic factor so that it can be absorbed into the blood stream.

Vitamin B 12 boosts mental alertness because it facilitates normal formation of body cells most especially the nerve cells. Vitamin B 12 is also an important component of the myelin sheath. Myelin sheath is necessary for the proper functioning of the nerves. Myelin sheath functions by increasing the speed of the movement of the impulse. With the presence of myelin sheath, the impulse hops from one sheath to another instead of just moving continuously along the nerve fiber. This is the reason why vitamin B 12 is commonly employed for boosting mental alertness and concentration. In fact, it is also commonly employed for treatment of memory loss and Alzheimer’s disease.

Vitamin B 12 can also help lower the risk of cardiovascular diseases by decreasing the concentration of homocysteine in the blood stream. Studies show that high levels of homocysteine can greatly lead to atherosclerosis which is the narrowing of arterial walls. It can also increase the tendency of abnormal blood clotting thus increasing the risk of clotting – related disorders. These factors can precipitate heart attacks and cerebrovascular accidents or commonly known as stroke.

Another function of vitamin B 12 is its involvement with energy metabolism in every cell of the body. Therefore, vitamin B 12 is not only good for enhancing mental alertness but also increasing energy levels. It is also required by the body so that other nutrients from the diet can be absorbed and readily utilized by the cells.

Vitamin B 12 is relatively safe. It usually comes in combination with other B vitamins in the form of tablets, capsules, or liquid which can be bought over –the – counter.

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Date: June 28, 2011 10:58 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Vitamin B12 Boost Mental Alertness, Improve Stress Tolerance And Circulation?

Can Vitamin B12 Boost Mental Alertness?

Vitamin B12 is an essential nutrient often added to energy boosters. It plays a central role in DNA synthesis in red blood cells, and deficiency leads to poor circulation of compounds necessary for brain health. It has been observed that the absence of this vitamin in the human diet for prolonged periods of time causes memory impairment, such as brain fog, or permanent damage to nervous tissue.

Also known as cobalamin, vitamin B12 is the only vitamin that contains the mineral cobalt, a chemical element that is considered rare at the cellular level, albeit essential in trace amounts. It was first linked to pernicious anemia, a condition that has been linked to cognitive impairment and neuropathic pain. In recent years, it has been suggested that this vitamin makes a healthy substitute for caffeine.

Prevents Brain Atrophy

Supplementation of vitamin B12 has been linked to the prevention and treatment of many known mental infirmities, such as depression, anxiety, and even Alzheimer’s disease. There is scientific consensus that cobalamin and other compounds that exhibit vitamin B12 activity inside the human body protect nerve cells from damage and modulate functions of the nervous system.

Several studies have noted that neuronal activities are impaired in the absence of cobalamin molecules in the body. On the other hand, their continued availability prevents brain atrophy. Vitamin B12 is necessitated in the production of myelin, which insulates nerve cells. When the myelin sheaths of neurons become fragile, the proper functioning of the nervous system is compromised.

Improves Stress Tolerance

Poor mental function often referred to as brain fog has been associated with numerous medical conditions, including sleep disorders, muscle weakness, and the like. Not surprisingly, these health problems result from physical exhaustion amid compromised nutritional well-being since all organic processes that take place in the human body must receive proper nourishment and adequate rest time.

In the event of chronic stress, regular intake of vitamin B12 provides a stronger resistance to physical fatigue. While cobalamin compounds are not a cure all for physical exhaustion and bad nutrition, they have shown great promise in improving stress tolerance. People subjected to physically demanding tasks or seemingly unending routines are certain to benefit from vitamin B12 supplements.

Promotes Healthy Circulation

Good nutrition is a component of a healthy lifestyle. Individuals who lead very active lives for long periods of time are able to do so because they get the right combinations of nutrients. Most athletes are conscious of their calorie intake and make sure they get the right amounts of nutrients in the form of supplements. In particular, vitamin B12 is an indispensable part of vitamin supplementation.

One of the few vitamins that are crucial to the upkeep of circulatory system is vitamin B12. Cobalamin is directly involved in DNA synthesis required for proper formation of red blood cells, and their presence promotes the normal functioning of red blood cells. The scientific community is convinced that this vitamin is responsible for healthy circulation, which contributes to mental clarity.

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Date: August 19, 2008 08:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Folic Acid

Folic acid is an important vitamin to the developing fetus in that it aids cell development, particularly those cells involved in the development of the baby's spine. A deficiency can result in neural tube defects, in which the neural tube, down through which the central nervous system passes, fails to close properly.

However, let's first discuss the substance itself so that its function in that process can be more easily understood. Neither should we ignore the other benefits that folic acid gives us, or the problems we can have in the event of a deficiency.

Folic acid is a form of Vitamin B9, sometimes referred to as Vitamin M. Its anionic form is known as folate, which is the form in which it is frequently offered in supplements. Incidentally, it gets its name from the Latin for leaf, so is from the same root as foliage. It is water soluble, and like Vitamin C can be leached through the body if not immediately used.

It is available naturally from leafy and green vegetables such as lettuce, broccoli, spinach and peas, but is also available in fortified breakfast cereals, sunflower seeds and some fruits. You would not normally suffer a deficiency, but if you are taking anticonvulsants, have liver problems or undergoing kidney dialysis, then you might need a supplement. Pregnancy, of course, is the important case in which a supplement should be taken, although, surprisingly, many mothers-to-be are unaware of this.

New body cells need folate for their production, particularly when they are dividing and growing rapidly such as during pregnancy and in infancy. The formation of DNA depends on many chemical entities, among them four nitrogenous bases, of which three, thymine and the two purine bases, adenine and guanine, depend on folate for their synthesis. If the growing fetus is lacking folate then DNA synthesis will be hindered. This retards cell division and growth.

Among the conditions this can cause are a form of anemia known as megaloblastic anemia, and neural tube deficiencies, where the sheath that surrounds the main nerve canal up the spine fails to close properly. The best known of such neural tube defects is spina bifida, though any condition caused by a lack of cell division can also occur. Anemia can be contracted by both adults and children, since production of red blood cells takes place constantly throughout your lifetime. These are the reasons why folic acid or folate is used in breakfast cereals.

The biochemistry is fairly simple to understand, and is important because it explains the importance of two other B vitamins, B3 and B12, in DNA synthesis. The initial stages are a six step reaction that forms methyl tetrahydrofolate from folate, starting with the reduction of folate to dihydrofolate, and then a further reduction to the tetrahydrofolate (THF). Vitamin B3 (in the form of nicotinamide adenine dinucleotide phosphate) is an essential cofactor for these reductions. Vitamin B12 is necessary as an acceptor for the methyl-THF so that it can continue along the biochemical pathway - now that is too complex to discuss here!

However, the inference you can rightly draw from this is that a deficiency of Vitamin B12 can cause what is known as a 'methyl trap', whereby the methy-THF cannot be used, and so a deficiency in Vitamin B12 can lead to the same symptoms as a folic acid or folate deficiency.

The implications of that are that vitamin B12 is also an essential component of a pregnant woman's diet. The problem here is that this vitamin is available only from animal sources, including dairy products. Its presence in vegetable organisms such as certain algae and fungi has been proposed, but it is believed that the cobalamin (chemical term for the vitamin) from these sources is not bioavailable to humans.

Vegans, therefore, who do not eat dairy products, will need a Vitamin B12 supplement in addition to folic acid or folate, particularly when they are pregnant and with young growing children. In this respect, a vegan diet is unsuitable for young children until their rapid growth period has stabilized.

For those of you wondering why the biochemistry above was discussed: that is your answer. Such discussions can frequently explain why certain supplements are necessary, or certain diets should be reconsidered under particular circumstances. Such things are easier to understand and accept when the logic behind them are explained. A folic acid supplement taken from the onset of pregnancy up to 12 weeks at least, and also a Vitamin B12 supplement in the case of those with a low meat intake, should prevent neural tube defects such as spina bifida.

A daily supplement of 0.4 mg should be sufficient, along with a diet rich in green vegetables, fortified cereals and breads and oranges. Your greens are best steamed since prolonged boiling destroys folic acid - as it destroys Vitamin C. One source of folic acid that you might read about is liver, and its additional iron content might lead you to believe this to be a good component of your diet when pregnant. However, although normally a very nutritious food, liver should be avoided during pregnancy due to its high Vitamin A content. This can be harmful to your baby.

Finally, there are some circumstances under which the dose during pregnancy should be greater. If you have previously had a child with a neural tube defect, or have an NTD yourself (or your partner), if you are diabetic, if you have celiac disease (a gluten allergy) or are taking anti-epileptic medication, you should increase your dose to 5 mg (milligrams) for which you will likely need a prescription from your physician.

NTD is rare, so don't over-worry much about it, but take the above precautions to put your mind at rest since pregnancy is not a time during which you should be nervous but to enjoy. That will pass on to your growing baby, which will then itself be happy.

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Date: July 24, 2008 11:19 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Essential Fatty Acids

A balance in essential fatty acids is crucial for many bodily functions. It promotes good overall health as well. Particularly, omega-3 fatty acids are essential for human development and achieving good health throughout life. The tissues of the body require omega-3 and omega-6 fatty acids in order to function properly. There are many conditions that are improved by supplementing with omega-3 oils including high cholesterol levels, prevention of strokes, cancer prevention/treatment, psoriasis and eczema, heart disease, high blood pressure, multiple sclerosis, and rheumatoid arthritis.

Diets that are high in saturated fat are often linked with high blood-cholesterol levels, which is a risk factor for cardiovascular disease such as coronary heart disease and stroke. Many diet therapies that aim to reduce the build-up of cholesterol and risk of CHD focus mainly on reducing the total and saturated fat intake. Dietary interventions that reduce saturated fat intake by simply three percent could even prevent about 100,000 new cases of coronary heart disease within the next 7 years. Once dietary saturated fats are decreased, they may be replaced with polyunsaturated fats, such as omega-3 fatty acids that lower both total cholesterol and LDL-cholesterol.

Although a person’s genetic inheritance has a lot to do with the likelihood of developing heart disease, it is becoming increasingly clear that modifying your lifestyle can improve the effects of your genes. Heart disease remains the leading cause of death in the U.S., but people can reduce their risk by adopting prevention habits. Some of the most crucial tactics are avoiding smoking, maintaining a desirable blood cholesterol level, keeping blood pressure in the normal range, and regularly engaging in aerobic exercise. Along with these lifestyle habits, alpha-linolenic acid can be taken as supplementation to improve the body’s ability to fight heart disease.

Alpha-linolenic acid has also been shown to lower the risk of stroke, which is the third leading cause of death in the U.S., after heart disease and cancer. Omega-3 fatty acids have also been shown to lower blood pressure by small but significant amounts and have also been able to lower levels of hypertension. Essential fatty acids also have the ability to reduce inflammation of the synovial fluid in the joints, which means that they can help in rheumatoid arthritis, a disease that affects at least forty million people in the United States.

Multiple sclerosis, a disease of the central nervous system that destroys myelin sheaths that cover the nerve and creates inflammation, has symptoms including blurred vision, dizziness, numbness, weakness, tremors, slurred speech, and staggering. Studies have shown that multiple sclerosis is at least partially caused by the deficiency of prostaglandins, which are produced from essential fatty acids.

Psoriasis, a skin disease that is characterized by patches of scaly skin on the knees, elbows, and scalp, but possibly anywhere, is considered essentially incurable by conventional methods, but dietary methods have offered some hope. Because of its rich essential fatty acid content, flaxseed oil is one of the natural therapeutic agents suggested for psoriasis. There is some evidence that suggests that a consistent supply of omega-3 oils may help to prevent fat-sensitive types of cancers, as well as inhibit breast, colon, prostate, and pancreatic cancers.

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Date: May 13, 2008 04:54 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Lipid content by percentage

Phosphatidylcholine (PC) 68% Assists in the introduction of DHA into the or Marine Lecithin heart muscle. Protects the mitochondria from oxidative damage, decreasing the impact of auditory and visual aging.

Phosphatidylethanolamine (PE) 11% Combined with PC, helps in the building of the myelin sheath.

Phosphatidylserine (PS) 9% The most widespread of all membrane PLs, protects from ischemic attacks (stroke) or age-related dementias.

Phosphatidylinositol (PI) 5% Acts on the regulation of cellular calcium. Has shown its effectiveness on obsessive compulsive disorders, panic attacks, depression, manic depression and Alzheimer’s disease.

Sphingomyelin (Sph) 5% Its pro-apoptotic activity decreases the risks of coronary hear t disease and cancer of the bowel (colon). Decreases parietal cell toxicity of bile salts. Sphingolipids are mostly present in the myelin sheathes.

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Date: April 30, 2008 03:03 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Shark Cartilage

Sharks do not have skeleton of bone but of cartilage, which is a dense form of connective tissue. Its main components are cells known as chondrocytes that are responsible for producing collagen fibers, an elastic protein called elastin that is responsible for the skin returning to its original shape after being pinched, and ground substance that is rich in proteoglycan, a protein with glycosaminoglycan chains.

Shark cartilage is said to be beneficial in the treatment of many conditions including arthritis, psoriasis (allied to arthritis), rheumatism, eczema, acne, allergies and the most controversial – cancer. It is said to inhibit tumor growth by inhibiting angiogenesis – the formation of new blood vessels by growing them from old ones. This can lead to metastasis, or the spread of cancer between organs and also feed the cancer cells with blood.

Shark cartilage has been used medicinally for thousands of years, particularly in ancient China where its use is documented, and might also have been in other areas where the consumption of fish was high. However, the production of shark cartilage and its trade is not well documented. The major cartilage consuming countries are Australia, India, Japan and the USA, although it is used or consumed in many other countries, especially Hong Kong, Taiwan, China and, increasingly, Europe.

The best quality of cartilage is from the blue shark due to its higher chondroitin quality. Chemically, chondroitin is an acid mucopolysaccharide, and a very large molecule that is used for a variety of purposes. In arthritis it is difficult to get it to the source of the problem due to its physical size and large doses are used to ensure that at least a proportion passes through the capillaries to the joints.

Arthritis is a particularly prevalent disease and comes in two forms: osteo- and rheumatoid arthritis. Osteoarthritis develops over a long period of time, and generally the cartilage roughens and becomes thin, while the bone becomes thinner. Extra synovial fluid, that lubricates the joint, can be formed and that causes swelling. The bone tried to repair itself, but degeneration continues and the tendons become affected. Eventually inflammation can occur leading to severe swelling and pain. There are several causes, the most common being injury or repetitive hard use of the joints.

Rheumatoid arthritis, on the other hand, is completely different, and is caused by the immune system rather than wear and tear. The immune system mistakes parts of your joints as being foreign, and attacks the synovial membrane, or lining of the joint. It might also attack the sheath around the tendons. This eventually causes the cartilage to thin and the joints to wear, and the inflammatory response can cause painful inflammations. There is no apparent cause, though heredity, lifestyle and hormones might all be connected.

The effect of shark cartilage on arthritis is well documented, and in one study in the 1970s, only 11% of patients did not respond well to a treatment of cartilage injections. The pain relief the injections provided lasted from six weeks to over a year, though no reason could be provided for the vast difference. However, it did seem to demonstrate that the remedy was more than just a placebo. In another study involving bedridden osteoarthritis patients, eight out of ten could leave their beds after only three weeks of oral cartilage treatment. Shark cartilage appears to be effective when administered both intravenously and orally.

In a later placebo study involving 147 arthritis patients, they were given either shark cartilage or a placebo. Those with the placebo were encouraged to use other treatments when their pain became severe. After five years the placebo group reported a 5% drop in pain scores compared to 85% of the group taking shark cartilage. The joint deterioration in each group was assessed, and was considerably less in the cartilage group, who also lost less time at work through pain.

All of these results indicate that shark cartilage can be used to relieve osteo- and rheumatoid arthritis pain in at least 60% of sufferers. Since rheumatoid arthritis has been linked to psoriasis, this could also explain its effects on psoriasis. What the studies did indicate is that you need not wait five years to find if the treatment is effective or not: if you do not experience positive results within between four and six weeks, then shark cartilage treatment will likely not work for you.

There is no doubt that shark cartilage can provide relief to painful, swollen joints, and this is likely due to the mucopolysaccharides. It can also prevent the undesirable growth of new blood vessels into the cartilage and appears to help to regulate the immune system. These are also two of the reasons why it is believed by some to be an effective treatment for cancer by preventing metastasis.

It was the publication of the book “Sharks Don’t get Cancer” that started the rush for shark cartilage as a a treatment for cancer, but the problem is that sharks do get cancer – they even get cancer of the cartilage! However, that does not mean that the scientific reasons for the inhibition of metastsis are invalid. They are valid, and it is metastsis rather than the original cancer that ferquently leads to death. Metastsis is the spread of the disease round the body by the bloodstream, and shark cartilage appears to be able to help to prevent that. It also prevents the growth of blood cells into cancerous areas to feed the cancers with oxygen and other nutrients.

Although there are few reported side effects of shark cartilage, in the interest of safety it is advised that children and pregnant women should avoid it. The same is true of people recovering from recent surgery since it could slow healing due to its effect on repairing blood vessels. If you have a low white blood cell count, do not have a shark cartilage enema since it can cause a potentially fatal infection.

Otherwise it should be safe to take, and is available in many forms including creams, capsules, powders and injections. The recommended dosage is 1 gram dried shark cartilage for each 7 Kg (15 lb) body weight. Once you begin to see an effect on the pain of your arthritis, one can then try to reduce the dose to 1 gram for each 18 Kg (40 lb) body weight.

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Date: March 08, 2007 12:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Revita

Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.

Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.

To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.

Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.

Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.

Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.

In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."

In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:

• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.

• 78.9% of subjects showed an increased mean value of hair diameter.

• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."

Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results.

Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:

• Total Number of Hairs: Significantly Increased

• Total Number of Terminal Hairs: Significantly Greater

• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher

• Hair Follicle Activation: Intensive

In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.

Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.

Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.

The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.

Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.

Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.

Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.

Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.

Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.

If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.

Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study.

The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.

After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.

Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.

MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.

The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.

MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.

Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.

The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.

According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.

The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.

Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.

Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.

The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.

Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.

Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.

Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.

L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.

The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.

Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.

In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.

Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.

Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.

Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.

Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.

After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.

This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.

Q. Is Revita safe ?

A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe.

Q: Can I use hair sprays, mousses, gels, etc.?

A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.

Q: Can I have my hair colored or permed while using Revita ?

A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.

Q: What is SLS/SLES free ?

A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.

Q: Can I blow dry my hair after using Revita ?

A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.

Q: Who is a candidate for Revita ?

A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.

Q: What type of results should I expect with Revita ?

A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.

Q. Does Revita have any systemic side effects ?

A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.

Q. Does Revita work for women?

A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.

Q. I am using other topical treatments. Can I use Revita at the same time ?

A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.

Q. Do I need to use Revita for a long time ?

A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.

Q: Is stress a factor in hair loss?

A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.

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Date: October 17, 2006 03:52 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Which Calcium is Best?

Customers walking into a health food store today are faced with a vast array of calcium supplements. They might ask: which one should I pick? Which one is best? Not easy questions to answer. All calcium forms will accomplish the same task: providing your body with a nutrient that it needs to build healthy bones and teeth; however, which form of calcium has the features that you want in a calcium supplement? Looking at shelves of calcium products is kind of like shopping for a car; there are many makes and many models—some are basic and others are more sophisticated.

Fortunately, there are many forms of calcium to satisfy your needs. Like the car lot, a health food store offers many options; therefore, you have to select a calcium product that consumers will feel confident in taking regularly and that will provide the most benefit.

Some consumers have done research and will come armed with information. They have already made choices based on advertising, word-of-mouth or an article they have read. They already know the form of calcium they want, be it a “Ferrari” or a “Ford.” If the client doesn’t have a specific preference: asking these basic questions will help in the selection process:

1. Do you prefer tablets, capsules, softgels, liquid or powder?

• Tablets are for consumers who want high dosage in fewer pills.
• Capsules are flavorless and may be easier to swallow than tablets for some.
• Softgels have a slicker surface and may slide down the throat more easily for some.
• Liquids are easiest to swallow and are available in different flavors.
• Powders are flavorless, versatile and can be mixed with food or beverages.

2. Do you have high or low stomach acid?

• Should you use calcium that has buffering action or a calcium that does not further reduce your stomach acid.

3. Do you have absorption issues?

• Rapid transit time in the bowels may affect a person’s choice of calcium.

What is calcium?

Calcium (Ca) is one of the most important minerals found in our bones and teeth—99 percent of body calcium is found there. But the calcium molecule does not like to travel alone and, in its more basic state, it comes bounded to carbon (C), Oxygen (O), and/or hydrogen (H) molecules or in more complex form, it is bonded to organic or amino acids that act as stabilizing carriers. On most labels, the amount of calcium listed actually indicates the pure or elemental calcium because it is that amount of the calcium that is deemed important to our daily supplementation, not the complex of the materials with which it is bonded.

Where does calcium come from?

Other than the calcium found in bone, the only natural form of calcium found in nature is calcium carbonate, a calcium molecule bonded to one molecule of carbon and three molecules of oxygen (CaCO3). One of the most common minerals on the face of the earth, calcium carbonate is called calcite, aragonite or vaterite by geologists. In its geological form, it constitutes approximately four percent, by weight, or the earth’s crust.

Commercial sources of calcium carbonate used to make supplements are: limestone, dolomite, oyster cell, egg shell, coral and sea water (have you ever seen that white deposit left by hard water? That’s mostly calcium carbonate). Calcium carbonate is the starting material for all other forms of calcium supplements. From this starting material, calcium can be reduced to more concentrated forms, such as oxide or hydroxide or it can be chelated (bonded) to organic acids and amino acids to help support enhanced absorption.

Lets look more closely at the different forms of calcium that are available as supplements.

Calcium Oxide (CaO): this form is 71 percent elemental calcium and is also called “lime” commercially. This is one of the oldest and most inexpensive forms of calcium used in a variety of commercial applications and it is occasionally used in supplements where space and price are a factor. It sometimes can be found in inexpensive mass market calcium/mineral combinations or multivitamin/mineral products and in a unique algal calcium from Japan. Unfortunately, CaO is a strong alkali that may cause stomach distress, which is why it isn’t often used in health food supplements.

Calcium Hydroxide (CaHO): at 54 percent elemental calcium, it is the next highest source of elemental calcium and is also known commercially as “slaked lime.” It is used where space is an issue. Although it is also a strong alkali, it is more stable than calcium oxide. It is most often used as a component of multi-mineral formulations or in addition to other forms of calcium (i.e., calcium citrate) to provide potency where space is an issue. It is not often used as a single ingredient in health food supplementation. This is for people who want a high dosage of calcium from a minimum amount of pills in multi-mineral formulas.

Calcium Carbonate (CaCO3): at 40 percent elemental calcium, it is the most widely used form of calcium in single ingredient calcium supplements as well as combination supplements. Inexpensive and an abundant source of elemental calcium, it is the only form of calcium found in nature outside of bone. It is the primary form of calcium used in the mass market and in antacid products. This is for people who have high stomach acid and who need a buffering type of calcium. Also for people who want a high dose of calcium in a minimum amount of pills.

Calcium Citrate: at 21 percent elemental calcium, it is one of the most popular forms of calcium supplements in the health food market as well as the mass market. This calcium salt does not lower stomach acid as much as calcium carbonate. This calcium salt is usually recommended for people who have low stomach acid, have had stomach surgery or who need a form of calcium that will not lower their stomach acid further.

Calcium Gluconate and Lactate: these two forms of calcium are high soluble. Since the amount of elemental calcium is much lower (9 percent and 13 percent respectively), they are used more often in powder form and mixed with liquids or food. When mixed in a beverage, the calcium is already dissolved and is ready to be absorbed. This is the best calcium salt for people who have overactive bowels, who have trouble swallowing pills or who don’t like the taste of pre-formed liquid calcium supplements. These calcium powders can be mixed in juices or smoothies or added to food as they are virtually tasteless.

Calcium Orotate and Asporotate: In the mid 20th century, Dr. Hans Nieper, a German scientist, advanced a theory that orotic and aspartic salt forms of calcium are transported directly to cell membranes for better absorption. The Solaray brand developed an asporotate formula, which combines three organic acids: aspartic acid (-Asp), orotic acid (-oro) and citric acid (-tate) into one product. The asporotate formula has become one of the most popular calcium formulas and is exclusive to the Solaray brand. This product is for customers who appreciate the idea of combining the enhanced absorbability of three organic acids into one. Aspartate and citrate are also part of the krebs (energy) cycle and are natural to the body’s metabolic systems and, according to Neiper, calcium Orotate and Aspartate are mineral transporters that enter into the cells to facilitate enzymatic actions rather than being extra-cellular. For people who believe that intracellular calcium is of importance, calcium Orotate and asporotate may be good choice.

Calcium Hydroxyapatite: this is another “natural form of calcium usually as a mineral ash form bovine source bone. Bone meal is also a form of calcium from bovine bone. These forms of animal derived calcium are for customers who want a source that is closest to their own bone matrix. Not for vegetarians.

Calcium Amino Acid Chelates (*HVP): this form is calcium carbonate bonded (Chelated) to a form of amino acid complex such as whole rice concentrate or other grain source. This form is for customers who want the additional bioavailability of amino acids.

Calcium AEP: Another form of calcium endorsed by Dr. Hans Nieper who theorized that calcium would cross the cell membranes more readily when it was combined with phosphatidyl ethanolamine or Amino Ethanol Phosphate (AEP), a nutrient found in nerve sheaths. This highly specialized form is for very educated customers who are proponets of Hans Niepers theory.

So, which form is best?

Calcium, like cars, comes in a variety of forms. Isn’t it wonderful that we have so many choices? The point is, there is no best one, there are only individual choices. Although we have our favorites, taking a calcium supplement, regardless of which one it is, should:

• Be a matter of personal choice based on how our body feels when taking it.
• Be in a form that is most convenient or appetizing so that we receive our daily requirements.
• Take into consideration any personal body limitations we might have .

Our primary concern when choosing a calcium supplement should be to provide our body with the right amount of calcium daily so that our skeleton and teeth can maintain proper mineralization and strength as the cells continuously break down and rebuild. The type of calcium complex we prefer is entirely up to us.

*HVP = Hydrolyzed Vegetable Protein

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Date: December 17, 2005 09:42 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: SAMe (S-Adenosylmethionine)

Supports Healthy Nervous System and Joint Function Vital For Over 35 Biochemical Reactions Necessary For Optimum Health Promotes a Healthy Mood

As the building blocks of protein, amino acids are vital to health. Next to water, amino acids in the form of proteins make up the greatest portion of our body weight. They comprise tendons, muscles and ligaments; organs and glands; hair and nails; important bodily fluids, and are a necessary part of every cell in the body.

There are over 20 amino acids, separated into two categories – essential and non-essential. Essential amino acids are those that cannot be manufactured by your body, hence, it is essential that you obtain them from your diet. Non-essential amino acids can be manufactured by your body, however, your body must have the right combination of essential amino acids and supporting nutrients to optimize healthy protein maintenance, so supplementation may be desirable.

Amino acids are not only absolutely integral to life, they can have a profound impact upon how clearly we think and how well we feel.

SAMe (S-Adenosylmethionine)

SAMe (S-adenosylmethionine) is a naturally occurring combination of the amino acid methionine and ATP (adenosine triphosphate), the body’s primary energy molecule. In this form it is sometimes referred to as “active methionine”. Research indicates that SAMe plays a vital role in nervous system health and normal cognitive function.*

SAMe may support nervous system function by increasing the synthesis and recycling of certain neurotransmitters and enhancing the sensitivity of nerve receptors. SAMe is believed to positively affect a number of neurotransmitters, including serotonin, dopamine, noradrenaline and norepinephrine. Although the mechanism for SAMe’s impact upon neural function is not fully understood, there is no doubt that SAMe’s capacity as a methyl donor is of critical importance.

As a methyl donor SAMe assists the body in the creation of complex organic compounds necessary for normal healthy function. Your body uses these new compounds for numerous purposes, including brain function and detoxification. This process, known as methylation or transmethylation, is vital to your body’s maintenance. SAMe may be the most effective of all methyl donors discovered to date. Research has shown that SAMe is the only methyl donor with the potential to increase transmethylation in the brain, which helps to protect it from homocysteine damage as well as increasing production of glutathione, one of the body’s most effective antioxidants.

Research into the biosynthesis of SAMe has established a clear link between SAMe and folic acid, or folate. Folic Acid has been proven to provide support for healthy nervous system function and a healthy mood, and researchers believe these two nutrients work together to beneficially affect monoamine systems, which directly affect mood and cognitive function.* SAMe has also been shown to improve the synthesis of phospholipids for use in the brain, probably one of the most beneficial effects SAMe has on brain health. The benefits of SAMe extend beyond the brain and throughout the human body. For example, it may also aid in the repair of myelin, the sheath of fatty material that surrounds nerves and nerve cells everywhere in our nervous system. It’s found in all human tissue and organs and is available for use by your body in over 35 different biochemical reactions necessary for optimal health.

SAMe may support joint health through transulfuration, a process that takes a certain amount of sulfur from SAMe to create glucosamine and chondroitin sulfates. This enhances proteoglycan synthesis, the molecule responsible for keeping articular (joint) cartilage lubricated. As mentioned earlier, SAMe is also important for the production of glutathione, a powerful free radical scavenger that defends your body from toxic agents and is necessary for liver detoxification.

SAMe was first isolated in 1952 by G.L. Cantoni at the Laboratory of Cellular Pharmacology at the National Institutes of Health, Bethesda, Maryland. Four years later, Cantoni and a co-worker found that SAMe synthesis involves methionine and ATP. They also found that it exists in the human body only temporarily, making production in a supplemental form difficult. It took nearly ten years until improvements in technology permitted SAMe research to advance. With the discovery of a method to stabilize SAMe that overcame these manufacturing problems, U.S. patents were granted to allow the production of SAMe in a stabilized form.

SAMe in its ion form, as found in human cells, has a very short life span and is rapidly metabolized into other necessary compounds as needed. Therefore, it must be manufactured in a stabilized form to prevent rapid degradation as a supplement. Once tableted, it must be enteric coated to preserve stability.

This technology was not readily available until the 1990’s, hence SAMe’s long road to mainstream popularity. Dr. Joseph Zhou, Director of Laboratory Methods here at NOW, is credited with significantly improving the analytical methodology used to assure potency levels in supplemental SAMe. His work is one of the reasons SAMe is available as a supplemental with stable, guaranteed

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Date: June 28, 2005 10:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Promilin Fenugreek Extract - Supports Healthy Blood Sugar Levels

The basis of Source Naturals PROMILIN™ FENUGREEK EXTRACT is fenugreek (Trigonella foenum-graecum), a respected culinary and medicinal herb used throughout history. One of the formula’s fenugreek extracts is rich in galactomannan, a mucilaginous fiber that may benefit the bowel. The other extract is Promilin, a patent-pending complex of bioactive amino acids standardized to contain 20% 4-hydroxyisoleucine. This extraordinary amino acid derivative assists the pancreas in production of insulin. Several studies with animals and with human cell cultures demonstrate this extract’s positive effect on reducing post-meal glucose levels — with little or no increase in blood insulin concentrations — a clear indicator of improved insulin sensitivity.

Sports Nutrition and Blood Sugar

Athletic energy and endurance depend on the ability of muscles to recover from exercise. Because PROMILIN promotes utilization of glucose and insulin by the the body’s muscle cells, “weekend warriors” will feel less fatigue on Monday morning. In a clinical study, PROMILIN increased glycogen re-synthesis by 63% over carbohydrate alone. This is the rate at which post-exercise muscle glycogen (energy) is restored. PROMILIN may also play a role in weight management because it helps your body metabolize carbohydrates more efficiently. And the less time glucose spends in your bloodstream, the less chance it will be converted into fat. By supporting glucose metabolism, Source Naturals PROMILIN™ FENUGREEK EXTRACT may help protect against a harmful process called glycation, where excess glucose reacts with amino acids to form crosslinked sugardamaged proteins that damage the linings of blood vessels, the lens of the eye, and the myelin sheath that insulates brain cells.

Benefits of PROMILIN

• Reduces body fat potential. Taking personal responsibility for your health and exploring safe natural alternatives to support prevention is the basis for the current revolution in health care. PROMILIN is a simple yet profound strategy for the increasingly recognized importance of maintaining proper blood sugar levels. Health food outlets are the center of this wellness revolution because only here can Source Naturals PROMILIN™ FENUGREEK EXTRACT and hundreds of other powerful natural compounds be found.

References
Madar Z., Abel R., Samish S., Arad J., 1988. Glucose-lowering effect of fenugreek in noninsulin dependent diabetics. European J of Clinical Nutrition Jan 42 (1): 51-4. Sauvaire Y., Petit P., Broca C., Manteghetti M., Baissac Y., Fernandez, Alvarez J., Gross R., Roye M., Leconte A., Gomis R., Ribes G., 1998. 4- Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion Diabetes Feb;47(2):206-10. Sharma RD., Ragtura TC., Rao NS., 1990. Effect of fenugreek seeds on blood glucose in type I diabetes; European J of Clinical Nutrition Apr 44 (4) 301-6.

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Benefits and Functions of Essential Fatty Acids

Date: June 25, 2005 08:29 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits and Functions of Essential Fatty Acids

Benefits and Functions of Essential Fatty Acids

The body takes combinations of different triglycerides and makes fats from them to help in various processes. The basic building blocks of any fats are the fatty acids. Fatty acids are either essential or nonessential. A fatty acid is considered essential if 1) the body is unable to synthesize it and 2) the only way it can be obtained is through the diet. In addition, it is considered essential if a deficiency will cause a disease. As far back as 1930 researchers discovered that if an animal did not get essential fatty acids in the diet, it could cause symptoms such as poor reproduction, lowered immunity, rough, dry skin, and slow growth, among others. There are basically three essential fatty acids. They are linoleic acid, linolenic acid, and arachidonic acid. Linoleic acid is the most vital. Linolenic and arachidonic acids can be converted from linoleic acid, but linoleic acid must be obtained from the diet. Most people are unaware of the many vital functions of essential fatty acids. The list includes:

• Acting as precursors to the production of hormone-like substances called prostaglandins. Gamma linolenic acid especially assists the body with this formation process.

Prostaglandins are found in almost all body cells, and act as catalysts for many physiological processes. They help prevent abnormal blood clotting and nerve inflammation. Prostaglandins also help promote blood circulation by dilating the blood vessels and improve immune system function. The most beneficial type of prostaglandin is called PGE-1. PGE-1 balances cholesterol and blood pressure levels, and stimulates the body’s production of T-lymphocytes which strengthen the immune capabilities. Each cell keeps tiny amounts of EFAs and produces prostaglandins from them as they are needed. The name prostaglandins was coined because these substances were originally found in high amounts in the prostate gland. To date, there have been discovered at least thirty-six different prostaglandins with a wide range of roles in the body.

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Winter Survival Kit

Date: June 13, 2005 07:35 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Winter Survival Kit

Winter Survival Kit by Joanne Gallo Energy Times, February 4, 2000

Now that the flesh-baring season is but a distant memory, skin care may have dropped off your list of priorities. But unless you're planning on hibernating until May, Old Man Winter can play a cruel joke on your smooth, glowing complexion-causing cumulative damage not easily remedied. Defend yourself with our survival kit and keep the harsh elements from wreaking havoc on your outer sheath.

Winter Blast

Frigid temperatures and blustery winds take their toll on everyone's skin, whether it's normal, oily or dry. Cold dry air, combined with arid indoor heat, results in less natural sebum (oil) production. This oil acts as a protective barrier that helps hold moisture on the surface of the skin; hence less sebum leads to a rough and dry exterior. Icy winds can also cause redness as the stress induces tiny capillaries just underneath the skin's surface to burst.

So the first order of business for winter skincare is preserving your skin's moisture. Along with external methods of bundling up all exposed areas, dietary habits can help preserve moisture internally.

Skincare consultant Lynn J. Parentini, author of The Joy of Healthy Skin: A Lifetime Guide to Beautiful, Problem-Free Skin (Prentice Hall), suggests reducing your intake of coffee and tea, which act as diuretics; eating lots of fresh fruits and vegetables, which contain natural, vitamin-rich moisture; and increasing the amount of water you drink (those daily recommended eight glasses of water are even more important in winter).

A Cleansing Experience

Bathing can strip skin of its natural oils, so you should be careful of washing with overdrying soaps. Avoid deodorant soaps with harsh detergents which can irritate the skin, and look for milder soaps with moisturizers or a skin-softening shower gel. Neutrogena Rainbath Shower & Bath Gels gently cleanse and condition skin with a rich, full lather that won't leave a residue. Showers tend to be less drying than baths, but if you prefer soaking in a tub you can use bath oil to lubricate the skin. Also avoid very hot showers and baths as they can pull moisture out of the body.

For extremely dry and sensitive skin, shower at night and follow with a rich moisturizer. Skin then can replenish its protective oils before the morning's icy blast.

Skin Savers

Now's the time to use a heavier cream moisturizer to counteract all these dehydrating forces, so finding the right one is imperative. In simpler times, choosing a body moisturizer came down to which one possessed the most pleasing smell. Today, lotions are formulated with nutrients and natural ingredients for powerful, soothing benefits. • CAMOCARE Soothing Cream contains patented Camillosan Camomile, a natural anti-inflammatory. This thick, therapeutic cream is great for dry patches on hands or elbows.

• Nivea Creme, developed in 1911, reportedly smooths roughness even 12 hours after being applied. More than 98% of Nivea's ingredients are natural, and its Eucerit base resembles human sebum.

Face the Season

Faces need extra-special protection during winter, as moisturizers do double duty to fight the elements and aging. Many formulas contain alpha (AHA) and beta hydroxy acids: gentle exfoliants that slough off the top layer of dead skin cells to allow younger, smoother-looking skin to emerge. • Oil of Olay's Age Defying Series: Protective Renewal Lotion contains moisturizers, a beta-hydroxy complex, vitamin E and SPF 15. • Neutrogena Healthy Skin Face Lotion is formulated with alpha-hydroxy acids to ease lines, blotches and discoloration; vitamin A and pro-vitamin B5 to increase firmness and moisture levels; and antioxidant vitamins C and E to fight free radical damage and protect new skin.

Sun Damage

So you think the sun is the least of your problems in the winter? Better reflect on that matter again. The general public has finally warmed up to wearing sunblock in the summer, but year-round protection against ultraviolet (UV) rays is crucial to avoid premature aging.

There are two types of UV rays, UVA and UVB: the former are responsible for aging and the latter for burning. Although UVB rays produce a more blatant sign of skin damage, it is limited to the epidermis, or outer layer of the skin.

UVA rays, on the other hand, don't cause any discomfort, but they penetrate deep to the dermis or second layer of skin. Researchers at the University of Pennsylvania Department of Dermatology have shown that chronic exposure to sunlight can cause holes and breaks in the elastin and collagen fibers that give the skin its shape, definition and supple quality. This damage is what is known as "photoaging." Severely photoaged skin appears dry, scaly, leathery, spotted and deeply wrinkled.

While the burning UVB rays are most intense during the summer months, UVA rays are prevalent year-round. Their effect on the skin is cumulative, so that the more you're exposed the more likely your skin is to age prematurely. And as only 14% of Americans wear sunscreen year-round (according to the American Academy of Dermatology), most of us are getting more UVA exposure than we realize.

" New clinical evidence proves that sun damages the skin much faster than previously thought," notes Zoe Draelos, MD, clinical associate professor of dermatology at Wake Forest University School of Medicine. "It only takes small amounts of sun exposure, such as walking to the car or to the mailbox, to start skin damage."

And for those who engage in popular winter sports like skiing, UVA rays are even stronger at higher elevations. Sunblocks with high SPFs (sun protection factor) guard against UVB rays but they do not block against UVAs, so many sunscreen products do not sufficiently protect against the entire range of UVA rays.

It is crucial, then, to look for products that guard against the entire spectrum of UVA/UVB rays. Sunblocks that contain zinc oxide, titanium dioxide or Parsol 1789 provide complete protection against aging and burning rays. Try Coppertone Shade UVA Guard SPF 30, Hawaiian Tropic 30 Plus Broad Spectrum Sunblock, L'Oreal Ombrelle Sunscreen Lotion or Spray in SPF 15, or PreSun Ultra SPF 30.

Lip Tips

Don't forget that the lips are particularly susceptible to sun damage too. In comparison to other facial skin, they have far fewer oil glands, no sweat glands, a much thinner protective outer layer and very few melanocytes, the cells that produce the protective pigment melanin. Accumulated sun exposure makes the lips less plump as UV rays damage their collagen and elastin fibers, resulting in rough spots, scaly patches or faded areas.

Even if you wear lipstick on a regular basis, most do not contain the sunscreens and conditioners you can find in a lip balm. Blistex offers a wide range of lip care products, like their new Blistex Herbal Answer, which contains the conditioning qualities of five natural, herbal extracts: aloe, chamomile, avocado, jojoba and shea butter, plus SPF 15; Blistex Ultra Protection with SPF 30 has six protectants for advanced defense against cold, wind and sun; Blistex DCT (Daily Conditioning Treatment) with SPF 20 contains aloe, lanolin, cocoa butter, and vitamins A and E to help keep lips soft and supple. o

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Thanks for the Memory

Date: June 11, 2005 03:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Thanks for the Memory

Thanks for the Memory by Estelle Sobel , February 6, 2002

Thanks for the Memory By Estelle Sobel

"I feel like every day, I lose my memory more and more. It started when I couldn't find my car keys, sometimes I forget directions. My mother has Alzheimer's so I'm concerned," says Jerry Solowitz, a 63 year old man.

Ellen Lerner, 37, sometimes worries that she can't keep track of everything in her job as a public relations executive. "I feel like stress can get to me easily, and I worry because I forget simple things like where I put a file."

Should these people be concerned?

"Yes," says Lynda Toth, Ph.D., co-author with Pavel Yutsis, M.D., of Why Can't I Remember? Reversing Memory Loss (Avery, 1999).

Jerry should start a specific program with a health practitioner who specializes in memory loss, due to lots of unsuspected new causes for memory dysfunction. Ellen needs to make lifestyle changes, as stress can definitely lead to memory loss.

"Cortisol, which is one of the stress hormones, can be harmful because it keeps calcium in the memory pathway too long and destroys the neurons, which is very damaging to the brain," notes Toth.

Why Does Memory Fail?

Memory fails for several reasons, says Augustine DiGiovanna, M.D., author of Human Aging: Biological Perspectives, (McGraw-Hill 2000), and Professor of Biology at Salisbury State University in Salisbury, MD.

Normal Aging: Much of diminished memory as we age is due to reduced blood flow to the brain from atherosclerosis, which is hardening and narrowing of the arteries. Decreased blood flow causes neurons to shrink and function less effectively.

Also, as we age we lose neurons and neuron connections that can lead to memory loss. So the way people think, how much they remember, and the mental activities they do determine how many brain cells survive through the years.

Finally, as people live longer, the chance is greater that the body's immune system and other defense mechanisms won't be able to protect against certain diseases that affect the brain and memory (Parkinson's, strokes, Alzheimers, atherosclerosis).

A Starving Brain: The brain is not getting fed the nutrients it needs (vitamins, minerals, amino acids, glucose). Without the right "food" the brain's energy levels become lowered and stop powering the memory cells. Then, free radicals can do more dirty work and continue to rust memory cells.

Drink And Sink: Alcohol passes through the blood-brain barrier and slows down the processing of information between memory neurons. Memory loss increases over time, as memory tissues shrink.

Sad Stories: Depression can imbalance the neurotransmitters and electrical charges of neurons.

Tense and Tight: High blood pressure can constrict and narrow blood vessels, limiting blood and oxygen flow to the brain.

Memory-Sustaining Supplements

One way to boost brain power is to take the right supplements.

Ginkgo biloba: The powerful medicinal herb ginkgo biloba increases blood flow and circulation to the head by dilating blood vessels in the brain, allowing more oxygenated blood to get to the neurons. It also protects against free radical damage.

Research: Ginkgo biloba extract displayed a significant effect on helping the mental abilities of people 50-59 years old (Phytotherapy Research 13, 1999: 408-415).

Pregnenolone: This powerful hormone regulates the balance between excitation and inhibition in the nervous system and helps enhance memory and brain function, possibly by repairing a fatty substance that is part of the myelin sheath that surrounds nerve cells. Research: A St. Louis University School of Medicine study on mice showed that pregnenolone enhanced memory and helped mice to navigate mazes better.

Huperzine A: This herbal supplement is derived from club moss found in China; in purified form it inhibits the enzyme that breaks down acetylcholine, a neurotransmitter produced in the brain that you need for memory.

Research: Studies conducted by Alan Mazurek, M.D., found that huperzine A in purified form improves memory, enhances focus and concentration and has been used to improve memory loss in Alzheimer's patients (Alt. Ther. in Health Med. 5 [2], March 1999: 97-98).

Another study in The Journal of Neuroscience Research showed that huperzine A is a potent inhibitor of cholinesterase, which penetrates the brain and produces a dose-dependent increase of the neurotransmitters acetylcholine, norepinephrine and dopamine in rat cortex (41, 1995: 828-835).

Phosphatidylserine (PS): This substance, which occurs naturally in nerve cell membranes, helps keep fatty substances soluble and cell membranes fluid and helps reduce levels of cortisone which are damaging to tissues.

Research: Phosphatidylserine encourages a sense of calm by raising the levels of alpha brain waves and increasing the production of acetylcholine (Neuropsychobiology 24, 1990-1991: 42-48).

Vitamin E: This potent antioxidant attaches to bad cholesterol and helps prevent free radical damage to cells.

Research: Age-related processes like memory function and problem solving can be affected by free radical damage. Several studies show that vitamin E might slow the effects of Parkinson's disease and Alzheimer's disease (JAMA 282, August 18, 1999: 621). Acetyl-l-carnitine: Increases cognitive performance because it rejuvenates cellular membranes of mitochondria, the storehouses of energy contained in every living cell.

Alpha-Lipoic Acid: Preserves memory tissue by increasing glutathione levels, which protect fat stores in neurons from being damaged.

Nine Ways to Remember

Dr. Lynda Toth suggests the following ways to make the most of what you've now got.

1) Power Up Your Smile. Remove dental fillings and replace them with porcelain or ceramic ones. The mercury in metal fillings may be harmful (some believe) and can affect the brain and nervous system, inflaming memory tissue and preventing the entry of nutrients into the cells.

2) Don't Be a Tin Man/Woman Avoid exposure to aluminum. Don't use aluminum pots to cook in. Aluminum accumulates in memory tissue, damaging cells. In fact, autopsies of Alzheimers patients show they have unusually huge amounts of aluminum in the brain. But no one knows where this aluminum comes from.

3) Eat Right. Eat organic and pesticide-free foods. Pesticides get into the cells and can damage DNA.

4) A Matter of Taste. Avoid foods with artificial coloring, monosodium glutamate (MSG, often called "natural flavors" or "natural seasoning"). Also avoid processed foods with taste enhancers called exito toxins such as l-cysteine and aspartic acid.

5) In the Raw. Make sure that your diet consists of enzyme-rich 50% raw foods (fruits and vegetables) to feed the brain. Eat less animal fats.

* Drink green juices to support levels of the brain's clean-up enzymes.

*Eat lots of fiber, which helps remove toxins from the body. Pick up psyllium fiber.

*Limit intake of processed sugar, caffeine and alcohol to lessen the load on the liver and pancreas.

6) Cut Bait. Watch the fish that you eat. Lots of ocean and inland-caught fish are contaminated with mercury. Go for deep, cold water fish such as cod. Avoid shark and swordfish.

7). Oil Up. Supplement your diet with omega-3 fatty acids, such as cod liver oil or flaxseed oil. These fats lubricate memory cells.

8) Work That Body. Stay fit and exercise. Exercise helps oxygenate the body, reduces cholesterol, and builds and energizes new memory cells which reduces wear and tear on the brain function.

9) Do Mind Games. Read, listen to music. Tune into different radio stations than the ones you normally listen to. Do crossword puzzles and a wide selection of word games which can stretch your brain and give it a tough workout.

Student of Life

You need to keep learning your whole life to keep your brain and memory in tip top shape. The brain is adaptable, and you are always building new neurons, says Dr. Toth, which means that there is no limit to how long it can develop. Anything that stimulates the brain will help it to grow. That's why as you get older it's even more important to take classes, start a new hobby, travel. In fact, the challenge of learning and doing new things (without stopping in a fit of frustration) causes your brain to grow, says Dr. Mazurek.

The Good News

As people get older, their brains may actually improve and repair themselves through a complicated process that is designed to eliminate faulty neurons that are prone to making mistakes. At the same time, brain activity goes on that results in the development of new and improved connections with neighboring neurons.

Research also shows that memory improves if you train people to have faith in themselves. (The brain helps those who help themselves.) Apparently, a confident perspective can encourage the brain to actually improve to the point where its new-found abilities may increase to the point where it fulfills expectations.

So keep your chin up and stay away from the artery-clogging saturated fat that can cut off the brain's blood supply. It's all in the attitude, says Dr. DiGiovanna. And, of course, the key to a long and happy life with your brain is also on the end of your fork and in that bottle of supplements.

Estelle Sobel, is the co-author of Beautiful Skin: Every Woman's Guide to Looking Her Best at Any Age (Adams Media, May 2000).

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R-Lipoic Acid - Fulfilling the Potential of Lipoic Acid

Date: June 04, 2005 02:23 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: R-Lipoic Acid - Fulfilling the Potential of Lipoic Acid

R-Lipoic Acid

Lipoic acid may be the body’s most versatile nutrient. Its critical importance for health is scientifically documented. Not only is it a powerful antioxidant, it supports healthy sugar metabolism and liver function, and is integral to energy generation, which affects all biological functions. But few know that the commonly available form, alpha lipoic acid (ALA), is not the same compound that occurs naturally in our bodies. ALA is a 50/50 combination of natural form r-lipoic and synthetic s-lipoic acid—and the synthetic form may actually block the activity of r-lipoic acid, resulting in a weaker product. Because it is the natural form, r-lipoic acid is better absorbed and safely metabolized. And it is up to 10 times more effective at producing cellular energy, according to in vitro research, and may be a more potent antioxidant. Source Naturals, the science company, is proud to be one of the first to offer this breakthrough nutrient: R-LIPOIC ACID

R-Lipoic Acid: Key to Cellular Energy Generation

Plants capture solar energy in their carbohydrates. In a reverse process called oxidation, animals extract that energy. R-LIPOIC ACID is a vital link in the metabolic pathway that gives us the power to move and the energy of intelligence. R-LIPOIC ACID is synthesized in the mitochondria, the tiny power plants inside every cell that produce energy in the form of ATP. It is safely metabolized and up to 10 times more effective than other forms of lipoic acid in mitochondrial ATP production, according to an in vitro study.

Supports Glucose Metabolism

Human and animal studies show that R-LIPOIC ACID can increase glucose uptake by muscle and nerve cells. By enhancing sugar metabolism, R-LIPOIC ACID may protect cells from glycation. In this detrimental process, excess glucose reacts with proteins to create tough crosslinked bonds that damage vital proteins, including the myelin sheath of neurons and the lens of the eye. Scientists believe glycation is a major source of tissue degradation and cellular aging. Collagen, another important protein, is also subject to crosslinking, which inhibits the flexibility of blood vessel walls—one of the most important indicators of cardiovascular health.

Increases Antioxidant Protection

R-LIPOIC ACID also neutralizes the harmful byproducts of glucose metabolism, free radicals. The body synthesizes barely enough R-LIPOIC ACID for its metabolic needs, and this decreases with age. As mitochondrial energy production becomes less efficient, more free radicals are generated. R-LIPOIC ACID protects cells, particularly in the mitochondria, where most oxygen damage occurs. R-LIPOIC ACID is a leading component of the body’s antioxidant network. Unlike other antioxidants, it is water and fat-soluble, so it neutralizes a greater number and broader range of free radicals, providing more protection. In animal studies, R-LIPOIC ACID slowed the aging process, which may be the result of cumulative oxidative damage. Lipoic acid, known as the “universal antioxidant,” is a strong antioxidant in its own right, but it also directly recycles vitamin C and indirectly recycles vitamin E for continued use. And R-LIPOIC ACID is more efficient than other forms of lipoic acid at increasing levels of the key antioxidants, CoQ10 and glutathione. Commercial alpha-lipoic acid is 50% synthetic s-lipoic acid, which can interfere with natural form R-LIPOIC ACID when both forms compete for binding sites. Tests showed 40% better absorption by R-LIPOIC ACID, as measured by plasma concentration levels.

Integral to Your Wellness Program

Because it is central to such critical functions as energy generation, antioxidant protection, anti-glycation activity, and liver support, R-LIPOIC ACID belongs at the center of your wellness program. Source Naturals is happy to join forces with your natural foods retailer in bringing you this advanced nutrient.

References:
Bonaventura, C., et al. 1995. Biochem Pharmacol 50(5): 637-46. Breithaupt-Grogler K. et al. April 1999. Eur J Pharm Sci 8(1):57-65. Hagen, T., et al. 1999. The FASEB Journal 13(2):411-8. Loeffelhardt S. et al. 1996. Biochimica et Biophysica Acta 1297:90-98. Lykkesfeldt, J. et al. 1998. The FASEB Journal 12:1183-1189.

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MYELIN SHEATH SUPPORT™ - Herbal-Nutrient Nervous System Support!

Date: June 04, 2005 10:15 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: MYELIN SHEATH SUPPORT™ - Herbal-Nutrient Nervous System Support!

Myelin Sheath Support

Planetary Formulas is pleased to introduce MYELIN SHEATH SUPPORT: a comprehensive formula designed to support the fat-like insulating sheath (myelin) that surrounds nerve tissues. Properly formed myelin is necessary for optimal nerve conduction. MYELIN SHEATH SUPPORT is the first formula developed for Planetary Formulas by herbalist and Ayurvedic specialist Alan Tillotson. It consists of some of the most highly regarded tonifiers of Chinese and Ayurvedic herbalism, along with additional key botanicals and supporting nutrients used with success in his practice.

Nervous System Support

MYELIN SHEATH SUPPORT is a broad-range herbal-nutrient formula that supports your nervous system with traditional Ayurvedic and Chinese botanicals as well as scientifically researched nutrients. Vitamin B-12 is key to the MYELIN SHEATH SUPPORT formula. It plays two critical roles: 1) it is essential for normal health of blood; and 2) it may function as a coenzyme in the synthesis of either the protein or lipid part of myelin.

Comprehensive Botanical - Nutrient Formula

Ayurvedic botanicals: Ashwagandha has been widely used throughout India for 3,000-4,000 years. It is one of the most highly regarded tonics in the 6,000-year old Ayurvedic tradition. Bacopa has been reported by Ayurvedic scholar Charaka to promote mental ability. Yogaraj guggul is one of the most valued botanical compounds of Ayurveda. The boswellic acids in boswellia inhibit leukotriene synthesis. Shilajit, a mineral resin that oozes from steep rocks in the Himalayas, is used extensively in Ayurveda. Curcuma (turmeric) has been used both internally and externally in Ayurveda. Curcuma is included in a dosage clinically shown to inhibit a group of enzymes that influence metabolism of arachidonic acid. Arachidonic acid is an unsaturated fatty acid found in most animal fats and is a precursor of prostaglandins. Chinese herbs: Included are the Chinese tonifiers panax ginseng and tienchi ginseng, as well as licorice extract (which is also prominent in European herbalism). MYELIN SHEATH SUPPORT delivers panax ginseng in amounts clinically shown to have adaptogenic (anti-stress) effects. Nutrients: Vitamin B-12, central for supporting the nervous system and specifically the myelin sheath, is included in the form of methylcobalamin. While a few forms of B-12 have been used clinically, it has been shown that methylcobalamin is a highly assimilable form of B-12, leading to increased retention in tissues. MYELIN SHEATH SUPPORT also includes zinc, copper, L-selenomethionine, boron, calcium, potassium, magnesium, chromium and pantothenic acid.

New Formulator!

Alan Tillotson is the newest member of the Planetary Formulas formulation team. He has been an ardent student of Ayurvedic herbalism, having engaged in an apprenticeship since 1976 with Ayurvedic scholar Mana Bajra Bajracharya, a practitioner whose family’s Ayurvedic lineage dates back 700 years. Planetary Formulas MYELIN SHEATH SUPPORT is available in bottles of 45, 90 and 180 tablets. Planetary Formulas: More than Herbs— Herbalism!

References
Ammon, H.P.T. et al. 1993. Mechanism of antiinflammatory actions of curcumin and boswellic acids. J. Ethnopharmacology: 38:113. Bhattacharya, S.K. 1995. Activity of shilajit on alloxan-induced hyperglycaemia in rats. Fitoterapia LXVI, 4:328-332. Linder, M.C. 1991. Nutritional Biochemistry and Metabolism with Clinical Applications. 2nd ed. Norwalk: Appleton and Lange, 138-143.

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Mental Edge - Support proper Brain Function...

Date: June 03, 2005 06:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mental Edge - Support proper Brain Function...

Mental Edge

Aging and nutritional imbalances can disrupt the multiple body systems that affect healthy brain function. The result: cognitive symptoms* such as forgetfulness, inability to focus, and mental fatigue. MENTAL EDGE® is a Bio-Aligned Formula™ that supports the interdependent body systems involved with healthy brain function. These include neurotransmitter production, myelin sheath generation, stress response, energy metabolism, and antioxidant defense.

Mental Edge®: A Bio-Aligned Formula™

Many scientists believe that only a small portion of the brain is fully utilized. MENTAL EDGE is a literal multivitamin for your brain. This comprehensive herbal-nutrient formula optimizes brain function by addressing the multiple body systems involved with cognitive health.

Neurotransmitter Production

Neurons (nerve cells) communicate with each other when neurotransmitters (brain chemicals) cross a small gap called a synapse to convey a message from one neuron to the next. Second messengers help transmit the message from the membrane of a receiving neuron to its inner environment. MENTAL EDGE supports neurotransmitter production with L-glutamine, L-phenylalanine, L-pyroglutamic acid, taurine, L-tyrosine, manganese, vitamins B-1 and B-6, and inositol.

Acetylcholine Production

Acetylcholine is one of the most important neurotransmitters. It is vital for memory and muscle movement. The ingredients DMAE, phosphatidylcholine, L-pyroglutamic acid, vitamin B-5 and choline are precursors to acetylcholine. DMAE is particularly important because it crosses the protective blood-brain barrier more easily than the others. DMAE also enhances mental concentration.

Stress Response

Adaptogenic herbs help provide the brain with the support and energy it needs to deal with the physical and mental stresses of an ever-changing environment. MENTAL EDGE supports stress response with the botanicals gotu kola, schizandra, and Siberian ginseng, and with the nutrients taurine, calcium, magnesium, potassium, vitamins B-5 and C, and inositol.

Energy Metabolism

Just as every cell needs the proper nutrients to survive, so do neurons. The brain accounts for 2% of our body weight, yet uses 15% of our total energy supply. Adequate levels of energy-generating nutrients are vital to the high-powered functioning of this organ. MENTAL EDGE supports energy generation with ginkgo biloba, L-glutamine, calcium, magnesium, manganese, potassium, zinc, B-vitamins, biotin and folic acid.

Myelin Sheath Generation

Myelin, composed of fat and protein, makes up the myelin sheath that forms a protective insulating covering around certain nerve fibers. Properly formed myelin increases nerve impulse conduction. MENTAL EDGE contains vitamins B-5 and B-12, which are needed for myelin sheath generation.

Lifestyle Tips for Cognitive

Health: A Strategy for WellnessSM Eat Well: Recent research suggests that diets rich in beta-carotene and vitamins C and E help reduce memory problems, probably by lessening oxidative stress. And new animal research at the University of Toronto found that a highfat diet slowed the ability of rats to learn new tasks. Use Your Brain: Learn a foreign language or new hobby, do crossword puzzles, read books, and cut back on TV. Scientists at Case Western found that people who were less mentally active in middle age were three times more likely to experience memory decline as they got older. Stay Active: Vigorous walking can improve mental processes in aging individuals, according to research. Aerobic exercise increases oxygenation and blood flow to the brain, resulting in improved memory, organization, and the ability to juggle intellectual tasks. Manage Stress: Long-term anxiety or depression can make a person more forgetful. Try to regulate stress, increase social contacts, and, if necessary, seek professional help. Get Organized: Make the most of your cognitive abilities through the use of memory aids such as “to-do” lists, notes, or calendars.

Neurotransmitter Production: L-Glutamine, L-Phenylalanine, L-Pyroglutamic Acid, Taurine, L-Tyrosine, Manganese, Vitamins B-1 & B-6, Inositol

Acetylcholine Production: DMAE, Phosphatidylcholine, L-Pyroglutamic Acid, Vitamin B-5, Choline

Antioxidant Defense: DMAE, Ginkgo Biloba, Zinc, Vitamin C

Stress Response Gotu Kola, Schizandra, Siberian Ginseng, Taurine, Calcium, Magnesium, Potassium, Vitamins B-5 & C, Inositol

Energy Metabolism: Ginkgo Biloba, L-Glutamine, Calcium, Magnesium, Manganese, Potassium, Zinc, Vitamins B-1, B-2, B-3, B-5, B-6, & B-12, Biotin, Folic Acid

Myelin Sheath Generation: Vitamins B-5 and B-12

*The term symptom as used above refers to the effects of nutrient shortages or imbalances and is not related to the diagnosis, treatment, cure, or prevention of any disease.

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Mega Mind - re-align your body systems ...

Date: June 03, 2005 05:24 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Mega Mind - re-align your body systems ...

MegaMind

Aging and nutritional imbalances can disrupt the multiple body systems that affect healthy brain function. The result: cognitive symptoms* such as forgetfulness, inability to focus, and mental fatigue. MEGAMIND™ is a Bio-Aligned Formula™ that helps align multiple systems: neurotransmitter production, antioxidant defense, energy generation, circulation, and myelin sheath generation. Complementary Formulations Source Naturals can help keep your mind sharp and alert. Use MENTAL EDGE® Bio-Aligned Formula for foundational support, or MEGAMIND, when memory symptoms* are severe. HIGHER MINDTM is an additional Bio-Aligned choice. Take these formulas alone or as the core of a program that includes additional ingredients such as DHA (NEUROMINS®), GINKGO-24™, PHOSPHATIDYL SERINE, VINCAMINE, and VINPOCETINE.

In today’s complex world, we are bombarded with information. Our ability to process this massive input depends on how well we nourish the multiple body systems related to brain health. In addition, normal aging is associated with impairment of certain mental functions, according to the National Institute on Aging. The brain undergoes changes including functional decline in neurons important to learning, memory, planning, and other complex mental activities, as well as increased oxidative stress. In healthy people, these changes may result in varying degrees of age-related memory decline. Source Naturals can help, with a full line of cognitive support products.

Mental Edge®: Bio-Aligned Formula

MENTAL EDGE is a literal multivitamin for your brain. MENTAL EDGE supports production of neurotransmitters including acetylcholine, antioxidant defense, energy generation, stress response and myelin sheath generation. It features nutrients needed for production of neurotransmitters— chemical messengers in the brain’s communication system. One of the most important of these is acetylcholine, which is necessary for memory and muscle movement. MENTAL EDGE also contains antioxidants—vitamin C, ginkgo, DMAE, and zinc—to protect the neuron cell membranes where electrical signaling takes place. Adaptogenic herbs provide the brain with support and energy to deal with environmental stress. Energy-generating ingredients such as ginkgo and B-vitamins are vital to the high-powered functioning of your brain. Vitamins B-5 and B-12 are also important for formation of myelin, a substance that forms a protective insulating cover around certain nerve fibers and increases nerve impulse conduction.

MegaMind™: Bio-Aligned Formula When memory symptoms* are severe, you may need a formula with extraordinary cognitive support. MEGAMIND addresses many of the same body systems as MENTAL EDGE, but does so with megadoses of brain nutrients, such as L-pyroglutamic acid and vitamin B-1 for neurotransmitter production. It also adds bacopa and the inhibitory neurotransmitter GABA to support neurotransmitter production, and higher potency vitamin B-12 for myelin sheath generation. Like MENTAL EDGE, MEGAMIND supports energy generation and antioxidant defense. MEGAMIND augments basic support for the brain’s immense energy requirements with higher potency vitamin B-1, and with one of nutritional science’s most advanced, high-tech nutrients, alpha-lipoic acid. Lipoic acid is also an antioxidant, as are gotu kola and grape seed. MEGAMIND also supports circulation with ginkgo and gotu kola.

Mega Mind: Bio-Aligned Formula HIGHER MIND is another multi-system support formula, which features phosphatidyl serine, a structural component of nerve cell membranes, and the botanical vinpocetine. HIGHER MIND nourishes neurotransmitter production, cell membrane stability, energy generation, antioxidant defense and myelin sheath generation.

Neurotransmitter Production: Bacopa, GABA, L-Glutamine, L-Pyroglutamic Acid, Taurine, N-Acetyl L-Tyrosine, Manganese, Vitamins B-1 & B-6

Acetylcholine Production: Acetyl L-Carnitine, DMAE, Gotu Kola, L-Pyroglutamic Acid, Vitamin B-5

Myelin Sheath Generation: Vitamins B-5 & B-12

Energy Metabolism: Acetyl L-Carnitine, Ginkgo Biloba, L-Glutamine, alpha-Lipoic Acid, Calcium, Magnesium, Manganese, Potassium, Zinc, Vitamins B-1, B-2, B-3, B-5, B-6 & B-12, Biotin,Folic Acid

Circulation: Ginkgo Biloba, Gotu Kola

Antioxidant Defense: DMAE, Ginkgo Biloba, Gotu Kola, Grape Seed, alpha-Lipoic Acid, Zinc, Vitamin C

Complementary Cognitive Support Products

For additional support, you can supplement Source Naturals Bio-Aligned formulas with these single ingredient products: ACETYL L-CARNITINE and DMAE are both important to the synthesis of acetylcholine, a key neurotransmitter associated with higher cognitive functions, such as learning and memory. DHA (NEUROMINS®) is an omega-3 fatty acid that plays a significant role in cerebral development, especially during fetal development and infancy. GINKGO is renowned for promoting blood flow to the brain. Source Naturals GINKGO-24™ is a standardized concentration of Ginkgo biloba leaves, yielding 24% ginkgo flavone glycosides and 6% terpenes (the key constituents). PHOSPHATIDYL SERINE is necessary for the health of nerve cell membranes, where electrical signaling takes place. These membranes are critical to information processing. VINCAMINE, an alkaloid obtained from the periwinkle plant, supports cerebral metabolism by promoting blood flow and oxygen and glucose utilization. VINPOCETINE is a derivative of vincamine, shown in research studies to improve cognitive performance and alleviate the short-term memory loss that may accompany stress or aging.

Lifestyle Tips for Cognitive Health: A Strategy for Wellness SM

Eat Well: Recent research suggests that diets rich in beta-carotene and vitamins C and E help reduce memory problems, probably by lessening oxidative stress. And new animal research at the University of Toronto found that a high-fat diet slowed the ability of rats to learn new tasks. Use Your Brain: Learn a foreign language or new hobby, do crossword puzzles, read books, and cut back on TV. Scientists at Case Western found that people who were less mentally active in middle age were three times more likely to experience memory decline as they got older. Stay Active: Vigorous walking can improve mental processes in aging individuals, according to research. Aerobic exercise increases oxygenation and blood flow to the brain, resulting in improved memory, organization, and the ability to juggle intellectual tasks. Manage Stress: Longterm anxiety or depression can make a person more forgetful. Try to regulate stress, increase social contacts, and, if necessary, seek professional help. Get Organized: Make the most of your cognitive abilities, through the use of memory aids such as “to-do” lists, notes, or calendars.

References
Braquet, P. Ginkgolides-Chemistry, Biol., 1988. FAO/WHO Expert Committee (1994). Food and Nutrition Paper No. 57. FAO: Rome. 49-55. Heiss, W.D., et al. (1993). Annals N.Y. Acad. Sci. 695: 327-31. Passeri, M., et al. (1990). Int. J. Clin. Pharm. Res. X(1/2): 75-79. Simopoulos, Artemis P. (1991). Am J Clin Nutr: 54. 438-63. Vorberg, G., M.D. Clinical Trials Journal 22.2 (1985): 149-57.

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Higher Mind - Smart Nutrients for the Performance of a Lifetime...

Date: June 02, 2005 12:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Higher Mind - Smart Nutrients for the Performance of a Lifetime...

Our adult years are the time to reap the fruit of an active, meaningful life – appreciated by family and friends who value our experience and knowledge. For some, however, their later years are clouded by a mental decline that erodes their capacity to enjoy life. More of us are becoming apprehensive about the future health of our minds. Will we still be able to communicate our needs as well as our wisdom? As science focuses its investigative might on the workings of the human brain, new findings suggest that it is possible to enjoy a vital, healthy brain and mind – well into old age. Based on compelling research, Source Naturals formulated HIGHER MIND. It contains the most important Neuroceuticals™ now recognized by nutrition scientists – including phosphatidyl serine, a natural nutrient that promotes cognitive function. The connection is clear: nourish your brain; enrich your life.

To have a healthy, well-functioning brain and nervous system, we need the correct nutrients. Our diets must provide the necessary raw materials for nerve cells to grow, for the synthesis of neurochemicals, and for the maintenance of nerve cell membranes. Nutritional deficiencies can alter the brain’s metabolism, which is expressed by changes in perception and thinking, behavior and mood.

Brain Cells – Issued at Birth

Before birth, neurons (nerve cells) are created at the amazing rate of 15 million per hour. As infants, we have over 100 billion neurons, but this is the most we will ever have because – unlike most other cells in our body – nerve cells do not reproduce. A different strategy is used to replace the neurons that are naturally lost throughout life: nerve cells repair themselves and grow by extending branches of nerve fibers called dendrites (from the Latin word for tree). These are the communication links with other neurons that form the circuitry of the brain. A single neuron may be in contact with up to a hundred thousand others! When the density of this fragile organic communication network decreases, we experience a corresponding decline in mental acuity.

Brain Cell Membranes

The membrane is the working surface of a cell. It needs to be strong yet flexible, so the cell can maintain its integrity and be able to move and change shape. The membrane regulates the flow of nutrients into the cell and the removal of waste, plus controls the passage of molecular messages from outside the cell to its interior. Membrane ion pumps use a third of the cell’s energy just to maintain the correct ratio of sodium to potassium. In neurons, a rapid exchange of sodium and potassium ions across the nerve membrane is responsible for their unique ability to generate the electrical impulses that are the basis of all communication in the nervous system. As cells age, their membranes become less fluid and more rigid. Key membrane molecules called phospholipids are crucial to the health of neuron membranes, allowing the brain to maintain its youthful quality. The phospholipids in HIGHER MIND – especially phosphatidyl serine and phosphatidyl choline – are essential nutritional supplements for the aging brain.

Phosphatidyl Serine – Key to Cognition

For the past decade, researchers have been investigating the role in brain health of a remarkable neuroceutical, phosphatidyl serine (PS). This key structural molecule is integral to the matrix of fats and proteins that compose cell membranes. Although PS is found in all the cells of the body, its highest concentration is in nerve cell membranes. PS is rarely found in the foods we eat, so the body has to synthesize it, but the process is energy- intensive and becomes less efficient with age. Consequently, our levels of PS tend to decline as we get older. PS taken as a dietary supplement is well-absorbed, readily reaching the brain, where it helps create more effective, well-structured nerve cell membranes. The positive effects of PS supplementation have been demonstrated by 23 clinical studies with over 1200 human subjects, ages 43 to 90. Consistent and statistically significant results have confirmed the value of PS in improving age-related cognitive decline, as well as in improving behavioral aspects such as apathy and withdrawal.1 A major study concluded that for one particular measurable parameter of higher mental functions, PS recipients achieved scores of persons roughly 12 years younger.2 Nerve Growth Factor (NGF) is one of the most important proteins the body makes. It enables neurons to extend dendrites out to other neurons, allowing the brain to maintain an effective communication network. In experiments, PS enhanced the production and reception of NGF, which tend to drop off radically with age.3 The effects of PS at the cellular level are manifest in the performance of the brain as a whole. Subjects taking PS showed increased levels of brain energy metabolism. This enhancement corresponded to higher performances on cognitive tests.4

The Chemistry of Thought

Science now understands the role of neurotransmitters in regulating the body’s complex network of behavior. Neurotransmitters are the chemicals used by neurons to communicate with each other. Activated by a neuron’s electrical impulse, neurotransmitters travel between nerve cells, where they excite or inhibit (in various degrees) the electrical impulse in neighboring cells. One of HIGHER MIND’S key strategies is to improve the brain’s ability to produce and use acetylcholine, a key excitatory neurotransmitter. Acetylcholine is essential for both the storage and recall of memory, and partly responsible for concentration and focus. It also plays a significant role in muscular coordination. Patients showing cognitive decline may exhibit reduced ability to synthesize and utilize acetylcholine.5 The chemical building blocks of acetylcholine and other neurotransmitters are called precursors. The most important one for acetylcholine is DMAE (dimethylaminoethanol). This natural substance is found in various fish, such as anchovies and sardines. Supplements of DMAE (and phosphatidyl choline) promote increased levels of choline in the brain. Acetylcholine is created when an acetyl group is attached to the choline molecule, with the help of choline acetyl transferase (CAT), a key brain enzyme. Acetyl L-carnitine is an amino acid that activates this enzyme. Acetyl L-carnitine may also help reduce lipofuscin deposits in the brain because of its involvement in the metabolism of fatty acids.6 Lipofuscin is composed of oxidized fats and proteins; the brown “age spots” on the back of an elderly person’s hand are made of lipofuscin. The amino acid L-pyroglutamic acid sensitizes the acetylcholine receptor sites on a neuron membrane. A given amount of acetylcholine will then have a larger, more powerful effect. Studies have shown that supplements of L-pyroglutamic acid seem to enhance the ability to focus, remember, and learn.

Total Nutrition for the Brain

The neurotransmitters dopamine and noradrenalin are critical to motor coordination, motivation, concentration, and alertness. Like acetylcholine, their production tends to decline with age. The precursors and activators of dopamine and noradrenalin included in HIGHER MIND are the amino acids N-Acetyl L-Tyrosine and DL-phenylalanine (DLPA), plus folic acid, vitamins B-3, B-6, and C. DLPA is also a precursor to PEA, a neuroamine that has a stimulating effect on the brain. Glutamine is an amino acid precursor to glutamic acid, a major excitatory neurotransmitter involved in mental activity and learning. Glutamine acts as an alternative fuel source for the brain when blood sugar levels are low. It also helps the brain dispose of waste ammonia, which is a natural result of protein breakdown but is irritating to neurons even at low levels. GABA is a dietary amino acid which is also an inhibitory neurotransmitter. GABA works to calm and balance the mind, enhancing mental focus. Along with taurine, these two relaxing neurotransmitters provide a balancing influence to the other, excitatory neurotransmitters. Taurine is found in brain tissue more than anywhere else in the body. It has antioxidant properties and serves as a nerve cell membrane stabilizer, preventing excessive or erratic electrical activity in the brain.

The Importance of Magnesium

Magnesium must be present in adequate amounts in the synaptic gaps between neurons or the neurons become hyper-reactive: causing noises to sound excessively loud and emotional reactions to be extreme. Magnesium also activates a key enzyme responsible for maintaining cellular sodium- potassium balance, which is absolutely essential to the electrical activity of nerve cells, as well as to the existence of the cell itself. (Cells would burst if the sodium-potassium ratio were wrong.) Magnesium also helps relax cerebral blood vessels and is important to the manufacture of ATP, the chief energy molecule of the brain. A buildup of aluminum has been found in the brains of some elderly. In 1989, the British medical journal Lancet published a study showing that drinking water with aluminum can increase the risk of damage by up to 50%. An abundant natural element, aluminum is now a common feature in our culture. It’s found in tap water, cookware, deodorants, beverage containers, baked goods, and of course as aluminum foil. In the brain, aluminum breaks down the structure of neurons – causing them to starve – by displacing magnesium from tubulin, a glycoprotein responsible for making microtubules. These tiny pipe-like structures within a neuron provide needed rigidity, as well as transport nutrients from the nucleus down the dendrites to the ends of the nerve cell. Magnesium malate is an excellent form of magnesium that ensures neurons receive this vital mineral.

B is for Brain Vitamins

HIGHER MIND also contains a high profile of B vitamins and other key nutrients that are often N A T U R A L S S O U R C E Strategies for Wellness SM ¤ lacking in older individuals. A deficiency in any of the B vitamins can alter nerve function and psychological well-being. Thiamine (B-1), known as the “nerve vitamin,” was first recognized because its deficiency caused beriberi, a degenerative nerve disease. Thiamine is part of the structure of nerve cell membranes and is important to the reparative process that neurons need to offset the stress of continual firing of the electrical impulse. Low amounts of thiamine can cause cell malnutrition in the hypothalamus, the brain’s memory center. 7 NAD and NADH, two coenzyme forms of Niacin (B-3), are the most plentiful coenzymes in the brain. They are essential to hundreds of enzymatic reactions, including ones that produce energy. NADH can stimulate the synthesis of key mood-elevating neurotransmitters. It is also one of the body’s most potent antioxidants. Pantothenic acid (B-5), cyanocobalamin (B-12), and folic acid are required to form the myelin sheath – the insulating covering of nerve fibers. A diet low in pantothenic acid has been shown to make test subjects emotionally upset, irritable, and depressed.7 A lack of B-12 can result in poor concentration and, in severe deficiencies, hallucinations. Pyridoxine (B-6) is precursor to over 60 enzymatic reactions and is involved in the synthesis of several neurotransmitters.

Brain Power

Brain cells almost exclusively burn glucose for their energy (other cells can also burn fat), and typically require 50% of all the glucose in the blood. Two B-like vitamins help in the utilization of glucose: PAK (pyridoxine alpha-ketoglutarate) may potentiate the effects of insulin and improve glucose utilization to the cells;8 Biotin is important for the transformation of glucose into energy in the brain. Lipoic acid and coenzyme Q10 are metabolic energizers that help produce ATP, the primary energy molecule in the body. Since the brain uses 20% of the body’s total energy supply, efficient ATP production is vital. Lipoic acid and CoQ10 are also powerful antioxidants that help regenerate other antioxidants in the body. The blood vessels feeding the brain become less efficient as we pass middle age. Since the brain depends on the bloodstream to deliver nutrients and oxygen and to remove waste, the quality of this blood flow is paramount to proper brain nutrition. Ginkgo biloba leaf extract has been shown in scientific studies to increase blood flow to the brain by helping vessels to dilate. It also promotes the smoothness and healthy integrity of blood vessel linings.

For the Life of Your Mind Without proper nutrition, the brain will deteriorate; therefore strategies are needed to both enhance current brain function and protect it throughout life. Based on the latest scientific findings, Source Naturals HIGHER MIND is formulated with neuroceuticals that support the mental functions that tend to decline with age. They give your brain the nourishment it needs to integrate perception, memory, and learning into a more comprehensive awareness – so you can excel for a lifetime.

References
1. Palmieri, G., et al. (1987). Clin. Trials J. 24: 73- 83.
2. Crook, T.H., et al. (1991). Neurol. 41: 644-49.
3. Nunzi, M.G., et al. In Phospholipids: Biochemical, Pharmaceutical and Analytical Considerations (ed. I. Hanin and G. Pepeu).
New York: Plenum Press, 1990.
4. Heiss, W.D., et al. (1993). Annals N.Y. Acad. Sci. 695: 327-31.
5. Passeri, M., et al. (1990). Int. J. Clin. Pharm. Res. X(1/2): 75-79.
6. Kohjimoto, Y., et al. (1988). Japanese Journal of Pharmacology 48(3): 365-71.
7. Philpott, William H. Brain Allergies: the Psychonutrient Connection. New Canaan: Keats, 1987.
8. Passariello, N., et al. (1983). Int. J. Clin. Pharmacol. Ther. Toxicol. 21: 252-56.

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Under-Reported (and Underappreciated) Cholesterol control.

Date: May 12, 2005 10:00 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Under-Reported (and Underappreciated) Cholesterol control.

Under-Reported (and Underappreciated) Solutions for Cholesterol and Triglyceride Control

by Richard Conant, L.Ac., C.N.

Fat and human existence are inseparable. Setting aside the fear and loathing over fat in the body that pervades our culture, we understand that fat is our friend. We cannot live without fat.

The human body contains many different kinds of fats and fat-like molecules. Collectively known as "lipids" these fatty substances include fatty acids, lipoproteins, phospholipids, glycolipids, triglycerides, steroid hormones and the infamous, dreaded cholesterol.

Lipids (fats) are found everywhere in the body, performing a variety of vital functions. The brain is a fat-rich organ. Brain neurons and all other nerve cells are protected by a myelin sheath, made largely out of fatty material. Cell membranes consist almost entirely of phospholipids (lipids that contain phosphorus) arranged in a sandwich-like double layer embedded with proteins. Sex hormones are lipids, belonging to the group of complex lipid molecules known as "steroids." Vitamin D is a lipid.

The body stores and transports fatty acids in the form of triglycerides. A triglyceride contains three fatty acid molecules, which have a chain-like structure, linked to glycerol. (There are also mono- and di-glycerides, which have one and two fatty acid chains, respectively, attached to glycerol.)

Like many other things necessary to life, fat is a two-edged sword. Fat insulates us from the cold, cushions and protects our vital organs and serves as a storehouse for energy. Yet, when present in excess to the point of obesity, fat threatens health, happiness, self-esteem, social standing and longevity. The same is true of other lipids, most notably triglycerides and cholesterol. Transported throughout the body in the bloodstream, these essential lipids become a health liability when the blood contains too much of them.

Keeping fat in it its proper place, not eliminating or drastically reducing it, is the goal we should seek. In the blood, lipids must be maintained at healthy levels and ratios. When they are, an important foundation of good health is established.

How do we keep the blood lipids we need——triglycerides and the various forms of cholesterol——balanced at healthy levels? Diet and exercise are indispensable, these basics must come first. Along with the recommended dietary practices, a number of nutritional approaches offer help for maintaining healthy blood lipids. We will now give several of these a closer look.

Gugulipid

In 1990, an herb used for centuries in the Far East was introduced to U.S. consumers. This herb, called "gum guggul," is proving to be one of the most effective natural cholesterol-lowering agents ever discovered. It also brings triglycerides down and raises HDL, the "good" cholesterol. The changes are substantial; gum guggul single-handedly normalizes the entire blood lipid profile, even in people with high starting levels of cholesterol and triglycerides.

Gum guggul, also called simply "guggul," is a gummy resin tapped from the Commiphora tree. A cousin of myrrh gum, guggul has been used by Ayurvedic herbalists of India for at least 3,000 years; texts dating from around 1,000 B.C. mention the herb. Guggul was traditionally given for rheumatism and poor health caused by excess consumption of fatty foods. One ancient Sanskrit text describes in detail what happens in the body when blood fats are out of balance, due to sedentary lifestyle and overeating. The name of this condition has been translated as "coating and obstruction of channels."

Intrigued by the obvious similarity between "coating and obstruction of channels" and arteries clogged by fatty plaque, Indian researchers initiated a series of experimental and clinical studies in the 1960's to see if gum guggul would lower excess blood lipids.1 Both human and animal studies consistently showed cholesterol and triglyceride reductions.

Detailed pharmacological studies showed that guggul's lipid-lowering effects are produced by compounds in the resin called "guggulsterones."2 An Indian pharmaceutical firm then patented a standardized extract of gum guggul under the trade name "Gugulipid." The product contains a uniform 2.5 percent guggulsterones, which is higher than guggul resin in its natural state.

Because Gugulipid guarantees the necessary intake of guggulsterones needed for blood fat reduction, it has become the product used in clinical research. Phase I efficacy safety trials and Phase II efficacy trials have yielded more positive data.3,4,5 Most of the studies on gum guggul have used relatively small numbers of subjects; this tends to make mainstream medical scientists reluctant about natural remedies. A large, well-publicized double-blind Gugulipid trial on 400 to 500 people would go a long way toward giving this herb the credibility it deserves.

Pantethine

Another effective natural solution for blood fat control that should be better known is a relative of pantothenic acid (vitamin B5). Pantethine is the active form of pantothenic acid in the body. Pantethine forms CoA, an essential co-enzyme for utilization of fat. CoA transports "active acetate," an important byproduct of fat metabolism that provides fuel for generating cellular energy. By promoting the burning of fats for energy, pantethine helps keep triglyceride levels down.6 Pantethine also helps regulate cholesterol production, by facilitating the conversion of fat into other lipid-based molecules needed in the body.6

Japanese researchers began studying the effect of pantethine on blood fats nearly twenty years ago. They reported their promising results at the Seventh International Symposium on Drugs Affecting Lipid Metabolism, held in Milan, Italy in 1980.7 Few in the medical or scientific communities took notice. Italian researchers followed up with several small clinical trials that confirmed the preliminary reports.6,8,9 An excellent cholesterol and triglyceride lowering agent that is safe and free of side-effects, pantethine remains, for the most part, ignored by mainstream science, although its usage is growing in alternative medicine circles. Pantethine it will no doubt prove to be one of the most important supplements for maintaining healthy blood fat levels.

Niacin

When taken in high enough doses, niacin (vitamin B3) substantially lowers cholesterol. This has been known to medical science for many years.10 studies on niacin as a cholesterol-lowering agent go back to the 1950's. There was a fair amount of initial enthusiasm for niacin because it improves, unlike most lipid-lowering drugs, all parameters of the blood lipid profile. Niacin reduces total cholesterol, LDL cholesterol and triglycerides. It also raises HDL cholesterol quite well. Interest in niacin has faded, in part because the necessary dose, 1200 milligrams a day or more, can cause flushing and gastrointestinal disturbances. Very high doses may be harmful to the liver if taken for too long.

There is a solution to the side-effect problem with niacin which, again, has failed to gain widespread attention. Inositol hexanicotinate is a flush-free form of niacin composed of six niacin molecules bonded to one molecule of inositol, another B-complex nutrient. Absorbed as an intact structure, inositol hexanicotinate is metabolized slowly, releasing free niacin into the bloodstream over a period of hours following ingestion.11 Inositol hexanicotinate has all the benefits of niacin for controlling blood fats. The flushing effect of ordinary niacin, which metabolizes much more rapidly, does not occur. Taking as much as four grams per day has not been reported to raise liver enzymes or cause other side-effects, but prudence dictates that people with liver problems should avoid very high doses of inositol hexanicotinate, or any form of niacin.12

Tocotrienols

We often think of vitamin E as synonymous with d-alpha tocopherol. Vitamin E is actually a whole family of compounds that includes various tocopherols and a group of lesser known but highly beneficial substances called "tocotrienols." All have vitamin E activity. Tocotrienols are similar in chemical structure to tocopherols, but they have important differences which give them unique and highly beneficial properties for human health.

Vitamin E is one of the most recognized antioxidants, nutrients that deactivate potentially toxic byproducts of oxygen metabolism known as free radicals. Vitamin E neutralizes peroxides, which result from the free radical oxidation of lipids, making it a key antioxidant in cell membranes. While d-alpha tocopherol has generally been regarded as the form of vitamin E with the strongest antioxidant activity, tocotrienols are even stronger.

The tocotrienol story is another example of a natural product slow to gain recognition. A Univeristy of California research team discovered that d-alpha tocotrienol is over six times more effective than d-alpha tocopherol at protecting cell membranes against free radical damage.13 In the presence of vitamin C, which recycles vitamin E-like compounds, its antioxidant activity is 40 to 60 times higher than d-alpha tocopherol. This study was published in 1991. Its safe to say few cardiac physicians know about tocotrienols, and we have yet to see 60 Minutes do a piece on "the powerful new form of vitamin E."

It would be a tremendous service to public health if they did, because the benefits of tocotrienols go far beyond their stellar antioxidant ability. Tocotrienols also lower total cholesterol and LDL, by impressive percentages. In one double-blind controlled study, tocotrienols reduced total cholesterol by 16 percent and LDL by 21 percent after twelve weeks. Another study recorded drops of 15 to 22 percent in total cholesterol along with 10 to 20 percent decreases in LDL levels.14 Now appearing on health food store shelves, tocotrienols are a health-protecting nutrients whose long overdue time has come. Derived from food oils such as palm oil and rice bran oil, tocotrienols have the same lack of toxicity as ordinary vitamin E.

References

1. Satyavati, G. Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii). Economic and Medicinal Plant Research 1991;5:47-82.

2. Dev, S. A modern look at an age-old Ayurvedic drug—guggulu. Science Age July 1987:13-18.

3. Nityanand, S., Srivastava, J.S., Asthana, O.P. Clinical trials with gugulipid. J. Ass. Physicians of India 1989;37(5):323-28.

4. Agarwal, R.C. et. al. Clinical trial of gugulipid—a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:626-34.

5. 'Gugulipid' Drugs of the Future 1988;13(7):618-619.

6. Maggi, G.C., Donati, C., Criscuoli, G. Pantethine: A physiological lipomodulating agent, in the treatment of hyperlipidemias. Current Therapeutic Research 1982;32(3):380-86.

7. Kimura, S., Furukawa, Y., Wakasugi, J. Effects of pantethine on the serum lipoprotiens in rats fed a high cholesterol diet (Abstract) Seventh International Symposium on Drugs Affecting Lipid Metabolism, Milan, Italy, 1980.

8. Arsenio, L. Bodria, P. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Clinical Therapeutics 1986;8(5):537-45.

9. Avogaro, P. Bittolo Bon, G. Fusello, M. Effect of pantethine on lipids, lipoproteins and apolipoproteins in man. Current Therapeutic Research 1983;33(3):488-93.

10. Crouse, J.R. New developments in the use of niacin for treatment of hyperlipidemia: new considerations in the use of an old drug. Coronary Artery Disease 1996;7(4):321-26.

11. Welsh, A.L. Ede, M. Inositol hexanicotinate for improved nicotinic acid therapy. International Record of Food Medicine 1961;174(1):9-15.

12. "Inositol hexaniacinate" (Monograph). Alternative Medicine Review 1998;3(3):222-3.

13. Serbinova, E., et. al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha tocotrienol. Free Radical Biology and Medicine 1991;10:263-275.

14. Qureshi, N. Qureshi, A.A. Tocotrienols: Novel Hypercholesterolemic Agents with Antioxidant Properties. in 'Vitamin E in Health and Disease' Lester Packer and Jürgen Fuchs, Editors. 1993; New York: Marcel Dekker, Inc.

Control Cholesterol with the following Supplements