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Curcumin: The Superfood That Fights Inflammation Darrell Miller 4/30/22
No to Pain Pills and Yes to Safe and Effective Curcumin Darrell Miller 9/4/20
Curcumin and Grapeseed Darrell Miller 9/1/20
A powerful antioxidant: Curcumin protects your heart from damagecaused by diabetes and smoking Darrell Miller 1/10/19
Curcumin may protect the brain after a traumatic brain injury Darrell Miller 1/8/19
A daily dose of turmeric could lead to improved memory and mood Darrell Miller 1/30/18
Turmeric : How women could benefit from this curry spice Darrell Miller 9/3/17
Curcumin Study Shows Improved Bone Density Darrell Miller 6/1/17
One plants broad based attack against cancer Darrell Miller 8/16/16
VITAMIN - D3:A reservoiur of benefits to sheenful life Darrell Miller 1/3/14
How Does Curcumin Reduce Inlammation In The Body? Darrell Miller 3/15/12
Turmeric and Alzheimer’s Disease Darrell Miller 5/10/07
Benefits - Supports joint function and tissue health* Darrell Miller 12/11/06
Curcumin - Turmeric Extract Darrell Miller 8/19/05




Curcumin: The Superfood That Fights Inflammation
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Date: April 30, 2022 09:39 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin: The Superfood That Fights Inflammation

Do you suffer from inflammation? If so, you're not alone. Inflammation is a common problem that can cause pain and discomfort in the body. Fortunately, there is a natural remedy that can help: curcumin. Curcumin is a compound found in turmeric that has powerful anti-inflammatory properties. We will discuss the benefits of curcumin and how to add it to your diet.

What is inflammation and what causes it?

Inflammation is a natural process that helps the body heal. It occurs when the immune system responds to an injury or infection. The symptoms of inflammation include redness, swelling, and pain. While inflammation is a necessary part of the healing process, chronic inflammation can lead to serious health problems. Chronic inflammation is often caused by lifestyle factors, such as smoking, obesity, and stress. dietary factors can also contribute to chronic inflammation, including a diet high in sugar. Sugar causes the body to release inflammatory chemicals that can damage tissues and lead to disease. Therefore, reducing sugar intake can help to reduce the risk of chronic inflammation.

What are the symptoms of inflammation?

Inflammation is a natural process in the body that helps to protect us from injury and illness. It occurs when the immune system detects harmful stimuli, such as pathogens or damaged tissue, and triggers a series of reactions which boost the production of white blood cells. However, if inflammation becomes excessive or chronic, it can cause a range of physical symptoms, including redness and swelling at the site of inflammation, increased pain sensitivity, headache, fatigue and fever. Other common symptoms include irritation in the eyes and mouth, digestive issues like diarrhea and nausea, rashes or skin lesions, changes in appetite and mood swings. If you are experiencing any of these symptoms on a regular basis, it is important to take anti-inflammatory supplements to help control inflammation. One such supplement is curcumin.

How can curcumin help to reduce inflammation in the body?

Curcumin is a compound that can be found in turmeric, a bright yellow spice commonly used in cooking. This powerful phytochemical has been shown to have potent anti-inflammatory properties, and can help to reduce inflammation throughout the body. One of the main ways that curcumin achieves this effect is by blocking an enzyme known as cyclooxygenase, or COX. This enzyme is responsible for producing pro-inflammatory compounds called prostaglandins that are often associated with pain and swelling. By preventing their production, curcumin can help to control acute and chronic inflammation in the body, thereby reducing the risk of conditions such as arthritis, heart disease, and cancer. In addition to blocking COX activity, curcumin helps to reduce oxidative stress by inducing production of antioxidants like superoxide dismutase. Overall, these mechanisms make curcumin an excellent natural treatment for chronic inflammation and a host of related health problems.

How to add curcumin to your diet?

Adding curcumin to your diet is a great way to reap the many health benefits of this powerful natural compound. There are several different ways that you can incorporate more curcumin into your daily routine, from simply adding it to your favorite recipes to taking a supplement. For example, you can start off by incorporating turmeric into your cooking, as turmeric is one of the richest sources of curcumin in nature. Additionally, there are many curcumin supplements available on the market that can be easily incorporated into your daily routine. Ultimately, by making these simple changes in your diet, you can enjoy all the great benefits of curcumin for overall health and well-being.

The benefits of taking curcumin regularly

Curcumin is a compound found in the spice turmeric. It has powerful anti-inflammatory and antioxidant effects, and it has been used for centuries in traditional Chinese and Indian medicine. Recently, curcumin has begun to gain recognition in the Western world as well. A growing body of research suggests that curcumin may have a wide range of health benefits, including the ability to improve cognitive function, reduce inflammation, and even ward off cancer. Curcumin is generally well tolerated, but it can interact with certain medications. However, for many people, taking curcumin regularly can be a safe and effective way to improve overall health.

To fight inflammation, reduce sugar consumption and take curcumin

To help reduce inflammation in the body, it is important to reduce your sugar intake and take curcumin supplements. These steps are vital because chronic inflammation has been linked to a wide range of health conditions, such as heart disease, diabetes, and even cancer. Additionally, sugar consumption can also worsen inflammation by triggering the release of inflammatory chemicals like cytokines and free radicals.

One of the best ways to fight against inflammation is to take curcumin supplements on a regular basis. Curcumin is a natural anti-inflammatory agent found in turmeric, a spice that is commonly used in Indian cooking. Research has shown that curcumin can be just as effective as anti-inflammatory drugs in reducing levels of tumor necrosis factor alpha (TNF-alpha), a potent inflammatory chemical released by cells. Furthermore, studies have also shown that taking curcumin regularly may benefit overall health and prevent certain age-related diseases like Alzheimer's.

Overall, reducing your sugar intake and taking curcumin supplements are two effective ways to fight inflammation and improve overall health. By following these simple steps, you can help protect yourself from the many negative effects of chronic inflammation.

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No to Pain Pills and Yes to Safe and Effective Curcumin
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Date: September 04, 2020 11:05 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: No to Pain Pills and Yes to Safe and Effective Curcumin

Many people turn to over the counter (OTC) drugs when they experience pain, the common ones are non-steroidal anti-inflammatory drugs, better known as NSAIDS. The problem with NSAIDS these drugs reduce an enzyme associated with pain called COX-1 and COX-2. There are a lot of hidden dangers behind prescription and OTC pain killers. Some of the most common ones consumed are Ibuprofen an d Acetaminophen.

Ibuprofen: a popular OTC pain reliever can cause stomach pain, nausea, gastric bleeding, ulcers, confusion, hypertension, increased heart attack and stroke. Also, swelling, rapid weight gain, reduced urination, which is a sign of kidney dysfunction, kidney failure, fever, sore throat, headache, rash, bruising, tingling, numbness, muscle weakness, neck stiffness, chills, light sensitivity, and seizures.

Acetaminophen: also known as Tylenol, is classified as an NSAID, but is also unsafe. The number one cause of liver failure in the United States is caused by acetaminophen next to alcohol consumption. If combined with alcohol, the damage to the liver is increased significantly. It also depletes glutathione, an important antioxidant needed by the liver to protect and detoxify the body. Over use of this OTC drug can cause nausea, vomiting, abdominal tenderness, and it can interfere with blood clotting, weaken kidney function, and with severe over dose can cause death.

The alternative: Curcumin is a safe and effective pain reliever

Curcumin is a compound from Turmeric Root, unstandardized turmeric powder contains only two to three percent curcumin. It is important to get a standardized curcumin so that you can get a therapeutic response from consuming this herb. Not all curcumin is the same, look for a brand that blends turmeric essential oil with curcumin to enhance the absorption of the product because the product is hard to absorb.

Curcumin is one of the worlds best studied herbs, it works by reducing a COX-2 response to inflammation the same target as many prescription and OTC drugs that cause organ damage and side effects. Fortunately, Curcumin can target the same in a safe and natural way with no side effects. It can prevent a wide spectrum of inflammatory and oxidative damage, relieve chronic pain as effective and much more safely than drugs like NSAIDs.

Taking OTC or prescription pain relieving drugs are not a long term solution for pain. With the side effects associated with common pain relievers, one should only take them as a last resort and consider using a safer alternative that is as effective to relieving pain. Terry Naturally offers BCM-95 a patented curcumin that is blended with turmeric essential oils, BCM-95 has been the subject of many clinical studies demonstrating its effectiveness in relieving pain. We at VitaNet offer free shipping on any product in Terry’s brand. If you are struggling with pain, consider trying Terry Naturally to help relieve pain safely.

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Curcumin and Grapeseed
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Date: September 01, 2020 11:03 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin and Grapeseed

Smoking, Chemical exposure, pesticides, nutrient deficiencies, to much sun exposure, and over the counter drugs and prescriptions can cause cancer. In the news, there are forever chemical roundup found in our water supply, it is no wonder we are laden with cancer as a society.

Fortunately, a healthy cancer preventing diet along with natural plant compounds can be far more effective and cost a lot less than conventional care alone.

Two top suggested natural medicines available right now are curcumin and grape seed extract. These two herbs are an amazing pair, curcumin is a fat soluble herb to fight oxidation on the fatty oil side in the body and grape seed extract is water soluble, making it a great antioxidant to fight oxidative stress on the water side of a cell. Cells in the body are made up of oil(fats) and water. The impact of both together on your health is virtually miraculous.

Curcumin neutralizes unstable free radicals that take electrons from nearby molecules, and stop them from creating a cascade of damaged cells. It also reduces inflammation reduces inflammation markers in the body to prevent prevent tissue degradation.

Curcumin has been shown to stop the changes that happen from free radical damage causing normal cells to become cancerous, and tumorous formations, and can even stop cancer from metastasizing or migrating to other parts of the body. Published studies anticancer activity have found that it can suppress breast, prostate, liver, skin, colon and lung cancer cells.

Curcumin Must Be Absorbed To Be Useful

One of the challenges or using curcumin for cancer prevention and treatment is that not all curcumin extracts are easily absorbable into the body. Blending curcumin in Turmeric essential oil enhances absorption and provides the additional benefits of ar-turmerone, a compound in the oil.

Curcumin Makes Chemo More Effective

There is big potential for curcumin when used with conventional treatment. BCM-95 curcumin, through research, has shown to sensitize human colon cancer cells to chemotherapy treatment where it would otherwise be resistant to this form of treatment. In some cases tumor recurrence rates can be as high as 60% but when treated with curcumin while under conventional treatment, curcumin boosted the effectiveness of the chemo drug 5-fluorouracil against cancer stem cells.

Curcumin has great potential in conjunction with conventional cancer treatment and recovery. It has been found that as chemo treatment progresses, cancer cells become resistant to the chemo treatment and the dosage has to be increased as the treatment continues increasing the toxic side effects. Fortunately, curcumin taken in conjunction with conventional cancer treatment can improve the effectiveness of chemo and so the dosage can be lowered reducing the toxic side effects for individuals. This is good news!

Curcumin Protects The Body During Cancer Treatment

In a clinical study with curcumin, it showed to alleviate side effects of one of the most common treatments of prostate cancer known as external beam radiotherapy (EBRT) where the doctor uses radiation to destroy tumorous cancel cells. This sort of therapy has many side effects making it a difficult therapy for most men. I often causes sexual dysfunction, digestive problems, urinary tract pain and loss of control. The higher the radiation dosage the more effective the treatment is but this causes significant discomfort, that is why most doctors lean towards lower dosages which makes the treatment less effective.

The clinical study administered 3000mg of BCM-95 curcumin that is 1000mg x 3 per day or a placebo one week before therapy started and during the treatment length. Each capsule of curcumin contained curcuminoids, curcumin, demethoxycurcumin, bisdemethoxycurcumin, and essential oil of turmeric, this is a full spectrum curcumin supplement.

At the end of the treatment which lasted 20 weeks the most dramatic difference between the two groups in the study was urinary symptoms. The curcumin group said a 50% decrease in symptoms or side effects of the radiation. Also, researchers noted that the curcumin did not reduce the efficacy of the EBRT.

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A powerful antioxidant: Curcumin protects your heart from damagecaused by diabetes and smoking
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Date: January 10, 2019 05:00 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: A powerful antioxidant: Curcumin protects your heart from damagecaused by diabetes and smoking





Both diabetes and routine engagement in tobacco smoking can raise the risk of cardiovascular damage due to a rise in oxidative stress. While curcumin isn't proven to completely diminish the amount of oxidative stress that is caused as a result of diabetic and tobacco consumption symptoms, it does greatly decrease the amount of oxidative stress that is experienced by each individual which naturally results in the heart being less vulnerable. It is also known to specifically reduce the amount of hyperglycemia-induced oxidative stress.

Key Takeaways:

  • It has been reported that taking curcumin supplements can protect a person from risk to cardiovascular diseases that is caused by diabetes and smoking.
  • This study was conducted at the Kind Saud University in Saudi Arabia. The researchers studied the oxidative stress caused by diabetes and smoking and curcumin’s effects on them.
  • The researchers found that administering nicotine to rats induced oxidative stress in the rats and also increased triglycerides and low-density lipoprotein.

"For the study, the researchers administered nicotine to diabetic rats to determine the effect of the combined oxidative stress of diabetes and nicotine."

Read more: https://www.naturalnews.com/2019-01-02-curcumin-protects-heart-from-damage-by-diabetes-and-smoking.html

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Curcumin may protect the brain after a traumatic brain injury
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Date: January 08, 2019 08:13 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Curcumin may protect the brain after a traumatic brain injury





Oxidative neurodegeneration is a process in which oxidative stress results in degeneration of the brain, often related to a traumatic brain injury (TBI). Studies are now showing that curcumin has protective abilities that can help decrease the brain's vulnerability to further injury as a result of oxidative stress. This could be due to several factors such as its anti-inflammatory properties, the way it increases antioxidants, and its natural healing properties that can aid in regeneration.

Key Takeaways:

  • Shockingly, traumatic brain injuries (TBI) affects several people in America. It is reported that they are sustained by about 2.8 million Americans every year.
  • It has been calculated that traumatic brain injury, TBI, is a cause of all injury-related deaths in America by about 30 percent.
  • Treatment for TBI which can include anything sufficient strong to cause brain injury to the head can include pain relief for mild cases, and ensuring adequate brain oxygen.

"When choosing a curcumin supplement, it is important to source one that is non-GMO, non-irradiated and preferably contains piperine (BioPerine) which enhances curcumin absorption by as much as 2,000 percent"

Read more: https://www.naturalnews.com/2018-12-26-curcumin-may-protect-the-brain-after-a-traumatic-brain-injury.html

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A daily dose of turmeric could lead to improved memory and mood
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Date: January 30, 2018 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: A daily dose of turmeric could lead to improved memory and mood





Turmeric spice can have positive effects on the brain, including beneficial effects on memory and mood. Curcumin, a chemical in the spice, also has anti-inflammatory and antioxidant properties. The American Journal of Geriatric Psychiatry conducted a study in which it was proven that mood and memory were were increased. In fact 28% did better on memory tests. Curcumin seems beneficial especially for older people experiencing some memory loss or those with symptoms of alzheimer's disease.

Key Takeaways:

  • Curcumin, a chemical in Turmeric, reduces inflammation. This has many health benefits, including improved memory and mood.
  • A published study that used a small sample of middle aged individuals, found that taking Curcumin twice daily could have health benefits.
  • The study found that those participants who took Curcumin twice daily for 18 months had improved their memory. Some participants saw improvements up to 28%.

"Curcumin, a chemical found in the popular spice, is being hailed by researchers as an anti-inflammatory with antioxidant properties, which, when consumed regularly, could help those suffering with age-related memory loss and mental health conditions."

Read more: https://www.shemazing.net/a-daily-dose-of-turmeric-could-help-improve-memory-and-mood/

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Turmeric : How women could benefit from this curry spice
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Date: September 03, 2017 12:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Turmeric : How women could benefit from this curry spice





Women can benefit a lot from a curry spice. Turmeric has a lot of different health benefits. The golden spice is filed with so many different nutritional properties that are great for your body. It can treat many different health issues that people experience. It can help treat diabetes and even colon cancer. There is new research that shows women benefit from it more than men do. This is a rather new finding that is important for women to know if they use turmeric in their diet.

Key Takeaways:

  • Curcumin has many health advantages including benefits for the liver and the skin.
  • Add curcumin spice to black pepper or coconut milk to increase the body's absorption.
  • Women's bodies absorb the medicinal form of curcumin much better than men.

"One way to boost curcumin absorption into the bloodstream is to mirror drug delivery methods in which the spice is put in liquid capsules to produce tiny nanomicelles."

Read more: http://www.deccanchronicle.com/lifestyle/health-and-wellbeing/300817/turmeric-how-women-could-benefit-from-this-curry-spice.html

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Curcumin Study Shows Improved Bone Density
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Date: June 01, 2017 07:14 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: curcumin study Shows Improved Bone Density





A pilot study that took place in Milan, Italy has made some remarkable findings. In this study a group of individuals were split into groups. One had the additional supplement of Curcumin added to their daily regime. After a period of time they were tested and it was found that the group that consumed the Curcumin had increased bone density. The test sites were the jaw and fingers. This is great news for people who suffer with bone density issues and more studies are underway.

Read more: Curcumin Study Shows Improved Bone Density

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One plants broad based attack against cancer
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Date: August 16, 2016 02:41 PM
Author: Darrell Miller
Subject: One plants broad based attack against cancer

There are a multitude of ways cancer cells can form,  lets look at a few ways and discuss them.

Epigenetics: A process that controls the behavior of genes.  Dietary and lifestyle choices can alter the way our genes work. Exposure to toxins can cause protective genes to goto sleep and allow destructive genes to awaken all due to the way we eat and live.  When this happens, disease can start.

Apoptosis: known as the programed life cycle of cells.  this natural cycle can be interrupted and when this happens, the cell does not die as intended, old and genetically damaged cells form tumors.

Angiogenesis: damaged cancer cells need nutrients and oxygen to survive.  Some cancers are able to form their own network of blood vessels.

Cancer Stem Cells: these are super cancer cells that can remain dormant for years which eventually activate and causes cancer to recur.

Cancer is a very complex disease, todays anti-cancer drugs are designed to address only one single pathway or gene with in cancer cells.  Since cancer is a complex network of hundreds of genes and pathways, conventional drugs are very unlikely to be effective in the end. 

Since a large majority of the drugs are designed around natural plants and their function, it would stand to reason that taking the natural plant would not only be effective but have zero side effects. 

Fortunately, we have a plant that has been validated by thousands of scientific studies.  This plant compound is called curcumin. 

  • Curcumin has shown positive results for virtually every disease it has been research and studied.
  • Curcumin is a strong anti-inflammatory plant and is also a strong antioxidant actually the highest of any food gram for gram.
  • Curcumin's anti-cancer properties make it unique and make it the ideal plant compound to conquer literally every type of cancer and many other chronic diseases.
  • Curcumin attacks cancer from many directions known as multi-targeting, making it more effective than drugs that are currently being used.
  • Preventative treatment is also preferable.  A healthy diet and lifestyle are scientifically proven to prevent and reduce cancer.  curcumin should be one plant compound everybody should be consuming to prevent cancer and many other disease.
  • Curcumin can be used in conjunction with conventional medicine to further boost healing in individuals who suffer from various diseases.

If you are somebody you know is suffering from cancer, you should seriously consider taking curcumin or telling family members about this wonderful plant compound.




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VITAMIN - D3:A reservoiur of benefits to sheenful life
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Date: January 03, 2014 05:29 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: VITAMIN - D3:A reservoiur of benefits to sheenful life

Vitamin D3 Sources

d3 food sourceA handful of sunshine everyday is what our body requires to retain its sheen and keep our health problems at bay. Human skin when exposed to ultraviolet rays of the sun manufactures vitamin D-3 orcholecalciferol for its consumption. It is recommended that lighter skin individuals receive 10 to 15 minutes of sunlight daily. Darker individuals, on the other hand, should receive almost double the amount of sunlight, up to 25 to 30 minutes daily. Other best natural food source for vitamin- D3 is fish products, such as: cod liver oil, tuna, salmon and sardines.

Apart from the tablets or liquid vitamin D-3 supplements, fortified milk, breads, cereals and eggs are lesser vitamin D3 sources.

Lists of health benefits for Vitamin D-3:

  1. VITAMIN D-3 is not only a boon to children's healthy teeth and bones, it is one such nutrient that work as a miracle to treat osteomalacia which causes muscle and bone weakening in adults. It may also reduce major medical risks in elderly if taken in high doses and improves immune system.
  2. It promotes calcium absorption thereby preventing loss of bone mass and treating several bone disorders.
  3. It lowers the risk of colon, breast, and prostate cancers.
  4. Rheumatoid arthritis and psoriasis is improved with vitamin D3.
  5. It not only prevents but also help treats rickets which later leads to bone deformities, post menopausal osteoporosis, hypoglycemia and the development of Type 1 diabetes.
  6. It also plays a significant role in slowing the degenerative process in multiple sclerosis and Chronic cerebrospinal venous insufficiency.
  7. Vitamin D-3 and curcumin synergistically clears brain tangles to help prevent depression and Alzheimer's dementia. There are multitudes of vitamin D receptors in the brain therefore it is believed to maintain and enhance mental health.
  8. It prevents PRE-Eclampsia which occurs during pregnancy and produces protein in urine, high blood pressure and edema. It leads to pre-mature labor and is the main cause of death during pregnancy.

References:

  1. //voices.yahoo.com
  2. //www.naturalnews.com/vitamin_D3.html
  3. //www.fitday.com/fitness-articles/nutrition/vitamins-minerals/health-benefits-of-vitamin-d3.html

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How Does Curcumin Reduce Inlammation In The Body?
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Date: March 15, 2012 07:53 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does Curcumin Reduce Inlammation In The Body?

Curcumin Health Benefits

Curcumin is an active component in turmeric plant (Curcuma Longa) and it is the component that gives yellow color in turmeric plant. The concentration of this component in turmeric plant is around 2-5%. Turmeric plant is a rather tall plant and it is mainly grown in India and other Asian countries.

For centuries, Curcumin has been used for Ayurveda, Chinese herbal medicine, and other Asian traditional medicine due to its various healing properties and low side effects. Besides being used for traditional medicine, this natural component is also used to increase energy, aid digestion, and reduce inflammation in the body.

The modern medical research of curcumin started in 1910. Since then, this turmeric's component is researched extensively by scientists worldwide to find its various health benefits. The followings are some of the benefits of curcumin and an explanation on how this natural component can help to reduce inflammation in the body.

Benefits of Curcumin

Many medical studies have shown that Curcumin has many benefits for human health. The first benefit is to cure digestive disorders. This natural component improves digestion by stimulating bile production in the gallbladder. Naturally, an increase in bile production can worsen stomach ulcers symptoms but many studies show that when the curcumin increases the bile production, it also reduce so stomach ulcers symptoms.

Benefits two

The second benefit of Curcumin is to cure heart disease. Heart attack occurs because there is atherosclerosis, the buildup of plaque that can block arteries. Curcumin helps people with heart disease by preventing the development of atherosclerosis. Many studies also show that this natural component is also helpful to lower cholesterol level in the body.

Another important benefit of this natural component is to cure cancer. This natural component has anti-cancer properties and many studies have shown that it can cure various types of cancers such as colon, skin, breast, and prostate cancer. It is able to limit the number of blood flow to the malignant tumors so the growth of cancer can be stopped.

How Curcumin reduces inflammation in the body

There are many ongoing studies that analyze the benefits of Curcumin to reduce inflammation. However in a 2006, a study has shown that this natural component is able to prevent joint inflammation in arthritis. The study shows that to reduce inflammation in the body, curcumin stops platelets from coagulating into blood clots and lowers the amount of two inflammatory enzymes, LOX and COX-2. Unfortunately, the study recommends consuming turmeric and not just the curcumin extract because turmeric has other properties that are helpful to reduce inflammation.

Considerations

Curcumin can easily be found in market as a spice but today it is also available in dietary supplement. Although it is safe to be consumed, there are several side effects that might occur after consuming this natural component such as diarrhea, nausea, upset stomach and heartburn. People who have gallbladder problems are recommended to avoid it because this natural component can induce gallbladder contraction. Pregnant women are also not recommended to consume it because it is a mild uterine stimulant. curcumin can be found under names like curamin, or turmeric at your local vitamin store.

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Turmeric and Alzheimer’s Disease
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Date: May 10, 2007 12:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Turmeric and Alzheimer’s Disease

Turmeric and Alzheimer’s Disease

 

In India, Alzheimer’s disease is relatively uncommon. People over the age of 65 living in certain rural areas of India have a less than 1 percent (0.84) chance of developing the disease. In the larger cities and rural areas of India, the risk is just 2.4 percent.

Compare these findings to people over the age of 65 living in the United States. Again, depending on where we are living, our chances of developing Alzheimer’s disease range from a little under 5 percent to an astonishing 17 percent.

So what are people who are living in India doing that we aren’t doing here in the US to account for these dramatic differences? The answer seems to be curry, that zesty spice and staple of Indian foods. Research has shown that a compound in curry not only prevents changes in the brain that lead to Alzheimer’s disease; it actually reverses some of the damage already present.

 

Q. How can curry prevent these changes in the brain? Isn’t that a lot to expect from a spice?

A. Evidently, it’s not too much to expect from this spice. Curry comes from the turmeric plant – Curcuma longa is the plant’s official name. Curcumin, a plant compound in turmeric, is the source of curry’s instantly recognizable bright yellow pigment. When it comes to the scientific research of Curcuma longa, the terms curcumin and turmeric are both used. Both refer to the same thing- tumeric extract.

There have been more than 1300 studies on tumeric and its health benefits for humans. Research has shown tumeric is able to help the body get rid of cancer-causing toxins. Turmeric also blocks estrogen receptors and enzymes that promote cancer. And it’s been found to stop the growth of new blood vessels in cancerous tumors – an important factor in keeping cancer from getting larger and spreading throughout the body.

But one of turmeric’s most exciting health benefits is its ability to reduce, prevent, and stop inflammation. While inflammation is a normal and needed response to injury or disease, chronic inflammation can cause damage to tissues. And researchers are now finding inflammation plays a huge role in Alzheimer’s disease.

 

Q. I’ve always heard that Alzheimer’s disease was caused by complex growths in the brain called plaques and tangles. How can simple inflammation cause such a devastating disease?

A. You are right. Plaques and tangles are indeed the hallmarks of Alzheimer’s disease. But researchers looking at the brain damage caused by Alzheimer’s have always noted the presence of inflammation wherever plaques and tangles form. In the past, this inflammation was thought to be simply a consequence of Alzheimer’s disease. Now scientists believe the inflammation itself starts a chain reaction ultimately contributing to the development of Alzheimer’s disease.

` When cells in the brain are disrupted by inflammation, amyloid, and a protein normally found in the brain, beings to act chaotically. This chaos results in the creation of beta-amyloid, protein that is toxic to cells in the brain. Sticky deposits of beta0amyloid build up and collect around the cells, making dense clumps or plaques. Because the brain can’t break the plaques down and get rid of them, they stay right where they are and slowly accumulate.

Tangles result when long protein fibers that act like scaffolding for brain cells begin to twist and tangle. The cell is damaged and eventually dies. But the tangled proteins remain in the brain even after the dead neuron has been cleared away. And inflammation might be the culprit causing the long protein fibers to start tangling.

The consequence of these abnormalities of protein in the brain is more than the cell death they cause. They also act as roadblocks interfering with electrochemical messengers being shot from cell to cell. Therefore, the remaining healthy cells’ activity is diminished as well.

Research of identical twins has repeatedly shown that if one twin has Alzheimer’s disease, the other has a 60% chance of developing the disease, too. Scientists from the Karolinska Institute in Stockholm, Sweden, looked at information from 20,000 twins collected in the 1960s and found 109 pairs of siblings where only one twin had been diagnosed with Alzheimer’s. When the Swedish researchers analyzed data about the twin’s health, they found the twin with Alzheimer’s disease almost always had chronic gum disease. While bleeding gums are definitely not he cause of Alzheimer’s disease, the inflammation that plays a large part of chronic gum disease may signal an inflammatory process stuck in overdrive.

In fact, the inflammatory process might occur years before the onset of Alzheimer’s, and be the result of any number of infections people can contract. That’s why current research is searching for ways to protect brain cells from inflammation. And why some countries have low rates of Alzheimer’s disease, like India.

 

Q. Why curry? Couldn’t other lifestyle difference account for the low rates of Alzheimer’s disease in India?

A. That’s a good question. When researchers begin studying a disease, like Alzheimer’s, they look for trends to help them determine how and why the disease occurs. For example, we all now know the connection between cigarettes smoking and long cancer. But, it wasn’t until the 1930’s that doctors noticed the trend fro cigarette smokers to have more lung cancer than people who didn’t smoke.

So it has been with researchers studying Alzheimer’s disease. They know Alzheimer’s disease has an important connection to inflammation. They also know turmeric reduces inflammation. And when researchers noticed these trends – that people in India eat high amounts of curry from turmeric and have very little Alzheimer’s disease – they began to theorize that turmeric might be able to prevent or even treat the illness. And the research they designed around these trends has unequivocally found turmeric to be on common denominator.

 

Q. What have the turmeric studies shown so far?

A. Simply amazing findings are coming from curry research. Not only does turmeric slow down cancer growth, it’s also been found to correct the cystic fibrosis defect in mice, help prevent the onset of alcoholic liver disease, and may slow down other serious brain diseases like multiple sclerosis.

Researchers from the University of California Los Angeles (UCLA) studying turmeric have found it to be more effective than the drugs currently being investigated for Alzheimer’s disease treatment and prevention. The researchers have discovered the actual structure and shape of turmeric allows it to penetrate the blood-brain barrier effectively and bind to beta amyloid that’s already built up in the neurons. Turmeric helps maintain healthy brain cellular metabolism, helps the cells repair themselves, and keeps the cells connected to each other. In other words, turmeric helps brain cells stay healthy.

And now the UCLA Alzheimer’s Disease Research Center (ADRC) is using turmeric in clinical trials and studying the effect of this powerful spice in patients diagnosed with this devastating disease. Clinical trials are the gold standard of medical research. But it’s rare in Alzheimer’s disease. And it’s even more rare when all-natural herbs and spices like turmeric are used in hopes the positive benefits will be discovered. The head of the UCLA’s research team was recently interviewed and stated that setting out to hopefully prove turmeric’s ability to prevent and treat Alzheimer’s disease was “tremendously exciting.”

 

Q. I recently read that one of the non-steroidal anti-inflammatory drugs (NSAID) was found to prevent Alzheimer’s disease. Is this true?

A. Scientists recently studied ibuprofen, one of the NSAIDs investigated for Alzheimer’s disease Prevention. Ibuprofen belongs to a family of drugs that includes naproxen, indomethacin, nabumetone, and several others. These drugs are used most often to get rid of headaches, mild arthritis, and other kinds of pain and inflammation.

In the studies, the average dose of ibuprofen was 800mg a day. Patients took the product for two years. While the results suggested that ibuprofen might reduce the risk of developing Alzheimer’s, ibuprofen’s side effects are too harmful to be a valid lifelong prevent aid treatment. Ibuprofen, like other NSAIDs, can cause gastrointestinal bleeding when used at high dosages over a long period of time. Long term use of ibuprofen can also lead to analgesic nephropathy, a kind of kidney damage caused by NSAIDs.

As we discussed earlier, turmeric appears to block and break up brain plaques that cause the disease and helps reverse some of the damage already present. Ibuprofen does not provide any protection against free radical damage. No anti-inflammatory medicine can do this.

 

Q. If I eat curry will I be protected against Alzheimer’s disease? There aren’t many foods or recipes I make that require curry, do I need to eat it every day? And how much do I need?

A. If you enjoy Indian cuisine, by all means, enjoy these delicious foods. You’ll benefit your brain and your appetite. But you make a good point, American meals rarely contain curry. That’s why supplements that contain extracts are suddenly quite popular. In fact, there are numerous turmeric/curcumin supplements on the market today.

But like all nutritional supplements, some turmeric supplements are superior to others. You need to read their labels to make sure the turmeric extract you are buying will provide the protection you need. Look for high-potency turmeric extract from turmeric (Curcuma longa) rhizome. And make sure the extract is standardized to contain 90% curcuminoids, the active ingredient in turmeric responsible for the positive research findings.

 

Conclusion

Researchers once thought that preventing for Alzheimer’s disease would elude them for decades. In fact, several scientists privately speculated the disease might never be ameliorated. They thought the origin of the disease was too complex and the symptoms of the disease were too profound.

That’s why ongoing research on turmeric is so exciting. A safe, natural, and effective way to protect against Alzheimer’s disease almost seems too good to be true. But, the nation of India and its low incidence of Alzheimer’s disease are proof these are not just fluke findings – making turmeric extract a supplement to remember.

 



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Benefits - Supports joint function and tissue health*
TopPreviousNext

Date: December 11, 2006 03:46 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits - Supports joint function and tissue health*

To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.

Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3

Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3

Promotes optimal joint comfort, function and flexibility*

Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4

Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7

Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8

Curcumin demonstrates several other in vitro effects linked to free radical scavenging. curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11

Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.

Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption*

Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14

Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.

Sustained Release – For lasting joint comfort and convenient dosing

To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.

Safety

Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.

Scientific References
1. Vidal y Plana, R.R., Bizzarri, D., Rovati, A.L. Articular cartilage pharmacology: I. In vitro studies on glucosamine and non-steroidal antiinflammatory drugs. Pharmacological Research Communications 1978; 10(6):557-569.

2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.

3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149.

4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.

5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.

6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002.

7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.

8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers.

9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46.

10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7.

11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.

12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34.

13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232.

14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J.

15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.



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Curcumin - Turmeric Extract
TopPreviousNext

Date: August 19, 2005 12:47 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Curcumin - Turmeric Extract

Curcumin

Turmeric- History and Traditional Usage

Native to Southeast Asia, Curcuma longa is a tall
tropical shrub with large oblong leaves and pale yellow flowers.
The genus “Curcuma” belongs to the Zingiberaceae family, which
includes ginger.1 The plant possesses a large root structure
with fleshy, bulbous underground parts called “rhizomes.” These
rhizomes, known as turmeric root, are harvested at maturity,
dried and cured for commercial use. Chemical analysis shows that
dried turmeric contains essential and volatile oils, with a
curcuminoid content of 2.5 to 5.0 %.2

In addition to its
popularity as a spice, turmeric is used as a dye for cloth and
coloring agent in foods and cosmetics, thanks to its rich yellow
color. Turmeric also serves as a preservative, probably owing to
the antioxidant and antimicrobial properties of curcumin.
Extracts of Curcuma longa have demonstrated in vitro
antibacterial and anti-fungal effects.3

Turmeric is named in
ancient Ayurvedic and Chinese herbal texts as a traditional folk
remedy. Historically, turmeric was used externally for wounds,
and sprains, and internally for digestive complaints,
rheumatism, liver disorders, coughs and colds.4
Benefits

Protects cells and tissues by fighting free radicals.*

Supports joint function*

The numerous beneficial
effects attributed to turmeric stem in large measure from the
antioxidant properties of curcumin. Antioxidants neutralize free
radicals, which are highly unstable molecules that can damage
cellular structures through abnormal oxidative reactions.
Curcumin is a potent “scavenger” of the superoxide radical, a
free radical that initiates potentially harmful oxidative
processes such as lipid peroxidation.5 Through this activity,
curcumin has been shown to protect skin cells from the injurious
effect of nitroblue tetrazolium, a toxin that generates
superoxide radicals. Curcumin also increases survival of cells
exposed in vitro to the enzyme hypoxanthine/xanthine oxidase,
which stimulates superoxide and hydrogen peroxide production.
Curcumin itself is not toxic to cells, even at high
concentrations. Pure curcumin was shown to be less protective
than a mixture of curcuminoids, indicating a possible synergism
among curcuminoids.6 Because free radicals are involved in aging
and exert harmful effects on skin, these results suggest
curcumin may help slow skin aging.

Curcumin demonstrates
several other in vitro effects linked to free radical
scavenging. curcumin scavenges nitric oxide, a compound
associated with the body’s inflammatory response.7 Pure curcumin
and turmeric extracts protect red blood cells from lipid
peroxidation induced by hydrogen peroxide.8 Curcumin has been
shown to protect DNA from oxidative damage, inhibit binding of
toxic metabolites to DNA, and reduce DNA mutations in the Ames’
test.9 Although additional studies suggest an anticarcinogenic
effect of curcumin, through protection of DNA,10 one in vitro
study found that curcumin induced DNA damage in human gastric
mucosal cells.11 It is speculated that curcumin may act as a
pro-oxidant in the presence of transition metal ions such as
copper and iron. (This is true for other antioxidants, including
vitamin C.) Curcumin also demonstrates in vitro inhibition of
COX-I and COX-II enzymes, which are involved in the inflammatory
reaction.12 Together these results strongly suggest that
curcumin is a potent bioprotectant with a potentially wide range
of therapeutic applications.

Animal studies- In vivo protective effects

Through its free radical scavenging
properties, curcumin has shown bioprotective effects in animals.
In one study, rats were treated with isoproterenol, a chemical
that causes cardiac hypertrophy (enlargement of the heart) due
to abnormal collagen metabolism. Co-treatment with curcumin
reversed the degradation of collagen and cardiac hypertrophy
induced by isoproterenol.13 Curcumin protects mice from
detrimental effects of radiation, by stabilizing the glyoxalase
system, a biological system that regulates cell division.14
Curcumin protects livers of rats from the damaging effects of
carbon tetrachloride (CCl4), a potent hepatoxin that injures the
liver via its free radical metabolite, CCl3.15,16 Curcumin
protected rats from alcohol-induced brain damage, in a study in
which oral administration of curcumin reversed lipid
peroxidation, reduced levels of free-radical metabolites and
increased levels of glutathione, a major physiologic
antioxidant.17 Curcuma longa extracts have shown
anti-inflammatory effects in rats.18

Human Trials

Curcumin exhibits free-radical scavenging ability when
administered to humans. In an open trial (uncontrolled), 18
healthy individuals ranging in age from 27 to 67 years consumed
a Curcuma longa extract, at a dose supplying 20 mg curcuminoids,
for 45 days. Before and after blood tests showed a statistically
significant decrease in lipid peroxides.19 Preliminary trials
have tested the anti-inflammatory action of curcumin, with
results that verify the traditional use of turmeric as an
anti-rheumatic herb. In a short-term double-blind, cross-over,
comparative study, 18 people received curcumin (1200 mg daily)
or phenylbutazone for two week periods. Both curcumin and
phenylbutazone produced measurable improvements in joint
flexibility and walking time. The subjects reported results only
with phenylbutazone, which may be explained by the short
duration of the trial.20 In a small placebo-controlled trial
comparing curcumin to phenylbutazone, 45 patients with
post-operative inflammation received curcumin, phenylbutazone or
placebo. The anti-inflammatory effects of curcumin and
phenylbutazone were comparable and superior to placebo.21
Curcumin has not been found to produce an analgesic (pain
relieving) effect.

Bioperine-Nature’s Absorption Enhancer
Boosts Curcumin Absorption*

Traditional Ayurvedic herbal
formulas often include black pepper and long pepper as
synergistic herbs. The active ingredient in both black pepper
and long pepper is the alkaloid, piperine. Experiments carried
out to evaluate the scientific basis for the use of peppers have
shown that piperine significantly enhances bioavailability when
consumed with other substances.22 Several double-blind clinical
studies have confirmed that Bioperine® increases absorption of
nutrients.23

Curcumin is poorly absorbed in the intestinal
tract, limiting its therapeutic effectiveness. Oral doses are
largely excreted in feces, and only trace amounts appear in the
blood. Concomitant administration of 20 mg of piperine with 2
grams of curcumin increases the bioavailability of curcumin by
2000%.24

Scientific References


1. Majeed, M., Badmaev,
V., Shivakumar, U., Rajendran, R. Curcuminoids. 1995.
Piscataway, NJ: NutriScience Publishers.
2. Srimal, R.C.
Turmeric: a brief review of its medicinal properties.
Fitoterapia 1997;68(6):483-93.
3. Ammon, H.P.T., Wahl, M.A.
Pharmacology of Curcuma longa. Planta Medica 1991;57:1-7.
4.
Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae).
The Protocol Journal of Botanical Medicine, Autumn
1995:43-46.
5. Rao, N.S., Rao, M.N.A. Free radical scavenging
activity of curcuminoids. Arzneim.-Forsch./Drug Res.
1996;46(2):169-171.
6. Bonté. F. et al. Protective effect of
curcuminoids on epidermal skin cells under free oxygen radical
stress. Planta Medica 1997;63:265-66.
7. Rao, S., Rao, M.N.A.
Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol.
1997;49:105-7.
8. Lalitha, S., Selvam, R. Prevention of
H2Os-induced red blood cell lipid peroxidation by aqueous
extracted turmeric. Asia Pacific J Clin Nutr
1999;8(2):113-14.
9. Deshpande, S.S., Maru, G.B. Effects of
curcumin on the formation of benzo[a]pyrene derived DNA adducts
in vitro. Cancer Letters 1995;96:71-80.
10. Subramanian, M., et
al. Diminution of singlet oxygen-induced DNA damage by curcumin
and related antioxidants. Mutation Research
1994;311:249-55.
11. Blasiak, J., Trzeciak, A., Kowalik, J.
Curcumin damages DNA in human gastric mucosa cells and
lymphocytes. Journal of Environmental Pathology, Toxicology and
Oncology 1999;18(4):271-76.
12. Ramsewak, R.S., DeWitt, D.L.,
Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory
activities of Curcumins I-III from Curcuma longa. Phytomedicine
2000;7(4):303-308.
13. Nirmala, C. Anand, S., Puvanakrishnan,
R. Curcumin treatment modulates collagen metabolism in
isoproterenol induced myocardial necrosis in rats. Molecular and
Cellular Biochemistry 1999;197:31-37.
14. Choudhary, D.,
Chandra, D. Kale, R.K. Modulation of radioresponse of glyoxalase
system by curcumin. Journal of Ethnopharmacology
1999;64:1-7.
15. Park, E-J. et al. Protective effect of
curcumin in rat liver injury induced by carbon tetrachloride. J
Pharm. Pharmacol. 2000;52:437-40.
16. Deshpande, U.R. et al.
Protective effect of turmeric (Curcuma longa L.) extract on
carbon tetrachloride-induced liver damage in rats. Indian
Journal of Experimental Biology 1998;36:573-77.
17.
Rajakrishnan, V. et al. Neuroprotective role of curcumin from
Curcuma longa on ethanol-induced brain damage. Phytotherapy
Research 1999;13:571-74.
18. Arora, R.B. Basu, N., Kapoor, V.,
Jain, A.P. Anti-inflammatory studies on Curcuma longa
(Turmeric). Indian J Med Res 1971;59(8):1289-95.
19.
Ramirez-Bosca, A. et al. Antioxidant curcuma extracts decrease
the blood peroxide levels of human subjects. Age
1995;18:167-69.
20. Deodhar, S.D., Sethi, R. Srimal. R.C.
Preliminary study on antirheumatic activity of curcumin
(diferoyl methane). Indian J Med Res 1980;71:632-34.
21.
Satoskar, R.R., Shah, S J. Shenoy, S.G. Evaluation of
anti-inflammatory property of curcumin (diferoyl methane) in
patients with postoperative inflammation. International Journal
of Clinical Pharmacology, Therapy and Toxicolgy
1986;24(12):651-54.
22. Atal, C., Zutshi, U., Rao, P.
Scientific evidence on the role of Ayurvedic herbals on
bioavailability of drugs. Journal of Ethnopharmacology
1981;4:229-232.
23. Bioperine®–Nature's Bioavailability
Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa
Corporation, Piscataway, N.J.
24. Shoba, G., et al. Influence
of piperine on the pharmacokinetics of curcumin in animals and
human volunteers. Planta Medica 1998;64(4):353-6.

© 2002
Doctor's Best, Inc. Revised 8/13/02

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



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