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Garlic for the Ages - eat garlic because it's good for your heart...

Date: June 13, 2005 09:58 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Garlic for the Ages - eat garlic because it's good for your heart...

Garlic for the Ages by Phyllis D. Light, RH Energy Times, January 1 , 2004

If you eat garlic because it's good for your heart, you swallow a plant renowned through human history: Garlic was eaten by Roman soldiers for courage; Egyptian slaves ate it to build strength; Christians, Moslems and Hindus include it in their sacred books. Others have used it as an aphrodisiac, a vampire deterrent and a magical charm.

Garlic has a long history as a culinary and medicinal herb that people either love or hate. Its pungent aroma and warming flavor captivates or repels, but its wealth of natural chemicals does great things for your heart.

Garlic (Allium sativum), a member of the onion family, is native to Siberia but, in modern times, has become a treasured naturalized citizen grown all over the world. Garlic's use in folk medicine dates back about 7,000 years, making it one of the oldest known medicinal foods or herbs.

In modern times, garlic is generally used as a condiment lending a unique, pungent flavor to dishes, but in medieval times, garlic was cooked and eaten as a vegetable in its own right. Today you can revel in a wealth of garlic choices, consuming garlic raw, cooked in various recipes, as a dried concentrated powder, as a fresh liquid extract or as aged garlic powder.

Powerhouse Herb

Each little clove of garlic is a powerhouse of good-for-you natural compounds, vitamins and minerals. The biologically active constituents of garlic include allyl sulfur compounds as well as the minerals germanium and selenium.

When you chop up raw garlic and allowed it to stand for about 10 minutes or more, the herb's fragments release an enzyme that converts its compounds from allyl sulfur to another natural chemical called allicin.

Although some allicin is found in garlic before it is cut apart, the yield multiplies considerably when the garlic clove is chopped or pressed and exposed to water (Garlic Conference, Newport Beach, 11/15/98; Penn State).

Many researchers believe that the more allicin produced, the better the health benefits. (Although this is still being debated among the garlic cognoscenti.)

But garlic's benefits don't end meekly on the kitchen counter with its allicin content rising.

Cooked garlic and aged garlic contain other helpful chemicals called diallyl sulphides. Consequently, in any form, garlic produces beneficial health effects.

Fortunately, since raw garlic juice or oil can often irritate the stomach lining, especially in people with sensitive stomachs and delicate digestive systems, garlic supplements and cooked garlic are both helpful for heart health.

Aged Garlic Extract

Aging garlic significantly reduces its irritating compounds and makes it easier on the stomach.

In the aged form, all of garlic's healthy sulfur-containing compounds are converted to water- soluble compounds that retain garlic's natural health benefits. In addition, the pungent odor of the garlic is greatly reduced, an outcome many people desire.

When a group of researchers at Brown University studied the effects of aged garlic extract on people's cholesterol levels, they found that after six months, cholesterol dropped about 6% (Am J Clin Nutr 1996; 64:866-70).

In another study from Brown, researchers found that aged garlic extract reduced platelet adhesion, a sticky blood problem that can cause vessel blockages (New Drug Clin 45(3):456-66). When platelets are less sticky, they are less likely to form blood clots that can cause heart attacks.

Garlic and Heart Disease

A growing body of research shows that a clove of garlic a day can significantly reduce your risk of heart disease.

A four-year study of 280 people who took dried garlic powder three times a day found a striking reduction in the types of arterial plaque blockages that threaten the blood supply to your heart. Interestingly, in this particular study, women displayed a greater reduction in plaque than men (Atherosclerosis 2000; 150:437-8).

Another study found that garlic may also keep important blood vessels more supple and less likely to spasm. Arterial spasms have been linked to heart attacks and other cardiovascular problems in women.

Aortic Complications

As you age, the aorta, one of the main arteries that carries blood, may harden, reducing blood flow from the heart and placing damaging stress on a number of other bodily organs. In research at Ohio State University, people who took garlic supplements had 15% less aortic stiffness than people who avoided garlic (Circulation).

In this study, scientists found that the older people enjoyed the greatest cardiovascular benefits from daily garlic use.

Researchers believe this extra benefit is linked to the fact that as you age, the endothelial tissue in the linings of the aorta and other blood vessels become less responsive to the need to dilate (expand). As a result, when more blood flow is required, and the heart pumps faster, these vessels take more of a beating from the friction of blood passing through them.

That restriction in dilation has two damaging consequences: In one instance, vessel walls can be injured. In response to these injuries, cholesterol collects on artery walls, plaque forms and the blood supply to the heart muscle can be restricted, leading to a heart attack. In other cases, arteries can restrict blood flow to the heart simply because of the inability to expand sufficiently.

The Ohio State researchers found that arteries in folks aged 70 to 80 benefited the most from taking garlic. But those in their 60s also benefited significantly.

Garlic's natural antioxidant properties can also help protect the heart from damage after surgery (BMC Pharmacology 9/02).

In a study performed on lab animals, researchers found that oxidative stress, a source of cell damage that takes place after surgery, dropped when the animals ate a diet that included garlic.

Oxidative stress can seriously reduce cardiac function, limit the amount of blood the heart can pump and cause permanent damage to the heart muscle.

Garlic Against Blood Clots

Under normal circumstances, blood clots serve a useful purpose: Cut yourself and a blood clot stops the bleeding. Without this clotting ability, you might bleed to death. But if your blood is too prone to clotting, these clumps can cut off blood supply to your heart and other organs, endangering your life.

In a study of apparently healthy individuals whose relatives had already suffered from heart disease, researchers found that their blood formed thick, tangled blood clots, increasing their risk of heart problems (Circulation rapid access 9/23/02). These blood clots are made of a substance called fibrin, a protein in the plasma that can form elastic threads that cut off blood flow.

While these researchers recommended aspirin as an anti-clotting measure for people at risk of heart disease, garlic can also help break up fibrin and possibly lower your chance of heart problems (Pharmatherapy 5(2): 83).

The fibrin that forms clots is produced by blood cells called platelets. Other scientists who have looked into garlic's benefits believe that one of its natural chemicals called ajoene may keep platelets from producing excessive fibrin and gumming up the flow of blood through arteries.

If you've rarely indulged in garlic, you may need a period of adjustment in growing accustomed to its unique taste and aroma. But its heart benefits confirm the long-ago observation by Pliny, an ancient Roman naturalist, that "garlic has powerful properties."

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Vitanet ®

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Hearty Nutrients

Date: June 10, 2005 03:52 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Hearty Nutrients

Hearty Nutrients

by Lisa James Energy Times, January 3, 2002

An American suffers a heart attack every 20 seconds. That adds up to 180 heart attacks every hour. Many of these life-threatening events don't have to happen: heart-healthy nutrients, weight control and exercise could ease this epidemic.

More evidence of how to protect your heart piles up every day, amounting to a stack of research thicker than the juiciest, most heart-threatening cheeseburger on a big, fat bun. To protect your heart, you've got to protect your arteries, the blood vessels that carry blood from the heart and also feed the heart muscle oxygen and nutrients.

Arteries are essentially three-layered tubes: the inner endothelium, a middle muscle layer which allows the artery to widen and contract, and an outer layer that encloses and supports the other two. When the lining, which is normally smooth, is damaged, the resulting rough patch develops plaque from LDL cholesterol, and the artery narrows and hardens.

When LDL cholesterol is oxidized into plaque, the resulting damage attracts large immune cells called macrophages which consume the oxidized LDL and get trapped in the developing plaque. Oxidized LDL is also associated with the death of muscle cells in the artery's middle layer (Circulation 2000; 102:2680). Plaque slows blood flow to the heart and can result in angina, chest pain often brought about by exertion. Heart attacks strike when unstable plaque ruptures, triggering blood clotting that blocks blood flow and may kill sections of the heart muscle as it's cut off from oxygen and nutrients.

Foods, like fatty meats, filled with saturated fat, are believed to start this heart-threatening process. Even by age 15, your arteries may be narrowing.

Antioxidant Action

Antioxidants can help keep your arteries functioning smoothly by counteracting LDL oxidation. Lab research has shown that cells in the lining can be protected by natural vitamin E. Eating a diet rich in vegetables, fruits and whole grains is an important step in stocking your antioxidant arsenal. But many heart experts recommend supplementation, a strategy that's been shown to bolster the body's defenses (J Nutr Biochem 2001; 12:388-95).

Vitamins C and E: The Dynamic Duo

Antioxidant allies abound, but two of the most important are vitamin C and natural vitamin E. They work particularly well together because C is effective in the fluid that bathes all cells, while E defangs free radicals in the fatty areas, such as cell membranes. And vitamin C actually recharges vitamin E, increasing E's antioxidant effectiveness. Each vitamin provides protective benefits on its own. People with Type 2 (adult onset) diabetes who took vitamin E in one study saw drops in cholesterol and glucose and increases in antioxidants, such as superoxide peroxidase, produced by the body itself (Endocr Res 2001; 27:377-86). For its part, vitamin C has prevented free radical damage in individuals who inhale secondhand cigarette smoke and has improved artery lining function in persons with coronary artery disease (Free Radic Biol Med 2000; 28:428-36; Circulation 1999; 99:3234-40). When used together, this vitamin dynamic duo provides powerful protection against both LDL oxidation and high blood pressure (Arterioscler Thromb Vasc Biol 2000; 20:2087-93; Hypertension 2000; 36:142-6). They also help keep immune cells from sticking to arterial linings (Circ Res 2000; 87:349).

Fighting Inflammation

Vitamins C and E also seem to prove effective against inflammation that researchers think contributes to heart health. Research in this area continues, but scientists now believe that inflammation from infections with herpes simplex one, the cold sore virus, and Chlamydia pneumoniae, a respiratory tract bug, can foment heart trouble. Inflammation may slow blood flow to the heart and make clots more likely. Among persons with peripheral arterial disease, blockages in arms and legs, not getting enough vitamin C levels may increase inflammation (Circulation 2001; 103:1863). Vitamin E apparently soothes inflammation by decreasing the release of immune chemicals and calming the immune cells involved in atherosclerosis (Diet and Optimum Health Conference, 5/01, Portland OR). Clot Busters Vitamin E also reduces the risk of clots and lowers the chance of a clot sticking in a vessel. It keeps platelets, cells that cause clotting, from becoming too gooey and breaks up fibrin, a clot-forming protein. Garlic (Allium sativa) also discourages inappropriate clotting. Used medicinally since the beginning of recorded time, the Greek physician Dioscorides thought it could clean the arteries. The ancient faith in garlic's circulatory benefits are supported by modern research. Recent studies have found substances in garlic that keep platelets from clumping together and lower cholesterol. In one study, men with high cholesterol who took garlic extract for five months saw their total cholesterol drop an average of 7% and their LDL drop 10% (J Nutr 2001; 131:989S-93S).

Hunting Down Homocysteine

Homocysteine, an amino acid found in the blood, may also be linked to artery problems. Scientists believe that when too much homocysteine accumulates in the bloodstream, arteries stiffen and plaque forms. The causes of this buildup remain murky but it appears that perpetually angry folks have higher homocysteine levels. Estimates vary on how much of a risk factor homocysteine represents; between 10% and 40% of people who suffer heart attacks may have high levels. Excessive homocysteine also seems to be linked to other risk factors, such as insulin resistance, a diabetes precursor (Diabetes Care 2001; 24:1403-10). The good news: the so-called DASH diet-featuring fruits, vegetables, low-fat dairy, whole grains, nuts and fish-may reduce homocysteine and drop your heart disease risk by 7% to 9% (Circulation 2000; 102:852-7). More benefits: simple B vitamins can control homocysteine. Folic acid (folate), along with vitamins B6 and B12, may help break it down and render it harmless. Taking these vitamins in supplement form has been shown to reduce homocysteine (Lancet 2000; 355:517-22). What's more, natural vitamin E may be able to restore artery lining function when homocysteine levels are high (Am J Cardiol 2001; 88:285-90). If you really want your ticker to tick stronger and longer, go long on your ready supply of heart healthy nutrients.

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Vitanet ®

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NATTOKINASE - A Systemic Enzyme for Healthy Circulation ...

Date: June 04, 2005 10:25 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: NATTOKINASE - A Systemic Enzyme for Healthy Circulation ...

Nattokinase

You may not have worried about the effects of aging when you were younger. But now, you are interested in staying fit. Maintaining your cardiovascular health – for women as well as men – may be one of your greatest concerns. Every tissue in your body relies on your heart to circulate blood through approximately 60,000 miles of your blood vessels. This complex network requires a holistic health approach. Enzymes, which accelerate chemical reactions, can help with a lot more than just your digestion. Systemic enzymes are a special class of enzymes that work on every system in your body to support your overall health. Source Naturals has searched around the globe to bring you NATTOKINASE, a systemic enzyme from Japan that supports the fibrinolytic blood clearing system. Reach for NATTOKINASE to promote your cardiovascular health today.

Supports Healthy Circulation

Source Naturals introduces the science of NATTOKINASE, the natural way to support healthy circulation. A systemic enzyme derived from the fermented soy food natto, nattokinase supports your body’s mechanisms for clearing blood to maintain your cardiovascular health.

Systemic Enzymes

If you are a mature man or women, then maintaining cardiovascular health may be one of your greatest concerns about aging. Every tissue in your body relies on your heart to circulate six liters of blood through approximately 60,000 miles of your arteries, veins and capillaries. This complex network requires a holistic health approach. You might think that all enzymes are just for digestion. Actually, enzymes accelerate thousands of chemical reactions in your body. And systemic enzymes are a special enzyme class that work on every system in your body to support your complete, or systemic, health. Different systemic enzymes, such as papain, bromelain, pancreatin and nattokinase, each work in different ways. The results can include reducing cellular irritation, promoting clear blood flow and supporting balanced immune reactions for your shortterm comfort and long-term health.

An Ancient Japanese Health Secret

The legend about the discovery of natto begins thousands of years ago with Yoshiie Minamoto, a famous Japanese warrior, who was forced to pack hot cooked soybeans in straw for traveling. When the soybeans were later unpacked, the sticky mess was considered spoiled. But when the horses, notoriously picky eaters, preferred this soy food, then people began consuming natto and discovering its health benefits.

How It Works

Healthy circulation occurs when your blood flows smoothly. It takes complex cascades of events to maintain this cardiovascular balance. Source Naturals NATTOKINASE can help. NATTOKINASE doesn’t inhibit blood clot formation. Instead, it works to support healthy circulation in three ways. First, nattokinase assists the fibrinolytic blood clearing system by breaking down cross-linked fibrin protein deposits in the blood. Second, in preliminary studies, natto extracts promote clear blood flow by reducing Euglobulin Lysis Time (ELT). Third, nattokinase supports blood clearing by breaking down Plasminogen Activator Inhibitor–1 (PAI-1), an inhibitor of an enzyme that helps keep blood flowing. Lifestyle conditions such as high stress, high glucose levels and high amounts of adipose tissue are associated with increased PAI-1 levels. Healthy circulation can do wonders to support your total health. When your circulation isn’t balanced, then your tissues aren’t getting enough nutrients and your blood isn’t clearing enough wastes away, which can increase cellular irritation and decrease overall cell health. Alternately, systemic enzymes such as nattokinase support healthy circulation so your tissues can get optimal levels of nutrients delivered and wastes removed for your better health.

Lifestyle Strategies for Maintaining Cardiovascular Health

Eat a Healthy Diet: A diet low in cholesterol, saturated fats and trans-fatty acids, and high in complex carbohydrates and fiber is important for your cardiovascular health. Good choices include fruits and vegetables, whole grains, lean red meats, fish and poultry without skin (up to 6 oz per day), lowfat or fat-free dairy products, beans and peas, and healthy fats such as olive oil in limited amounts. Avoid sugar, which has been reported to increase risk factors linked to heart disease. Some healthy cooking tips include using a rack to drain off fat when you broil, roast or bake; using wine, fruit juice or marinades to baste; broiling instead of pan-frying; using a vegetable oil spray to brown or sauté foods; and cooking with egg whites instead of yolks. Exercise Regularly: Maintaining healthy cholesterol levels is important for supporting your cardiovascular system. Exercise may increase heart healthy HDL cholesterol and lower blood triglycerides (fats), partly because of the decrease in total body fat and increase in muscle mass that usually accompanies exercise. A recent study reported that dietary changes improve cholesterol levels only when an aerobic exercise program is also included. Regular aerobic exercises—brisk walking, jogging, swimming, biking, aerobic dance, and racquet sports—are the best forms of exercise for lowering LDL and raising HDL levels. Experts recommend that people aim for a routine of 30 minute brisk walks most days of the week; an excellent goal is 20 to 25 miles a week, but in terms of raising HDL levels, more is better. Resistance (weight) training offers a complementary benefit by reducing LDL levels. Quit Smoking: Cigarette smoking lowers HDL cholesterol levels and is directly responsible for approximately 20% of all deaths from heart disease. The toxic effects of cigarette smoke damage blood vessels in the heart and legs. In fact, smoking doubles an individual’s risk of heart attack with any level of blood cholesterol. The importance of breaking this habit cannot be emphasized enough. Drink Alcohol Only in Moderation: Many studies have reported that modest consumption of alcohol increases HDL levels and protects against heart disease and possibly stroke. However, since alcohol consumption can cause other health problems, you should consult your health care professional about alcohol use. It has been suggested that antioxidants in red wine such as flavonoids and polyphenols contribute to alcohol’s protective properties. Take the Right Supplements: Many supplements can help support your heart health. Folic acid, one of the B vitamins, supports arterial health by balancing homocysteine levels. Magnesium, potassium, and calcium all help to maintain heart muscle health. Antioxidants such as betacarotene, vitamin C, vitamin E, and those found in extracts of green tea support blood vessel integrity. And omega-3 fatty acids, such as those found in flax seeds, cod liver oil, and other dietary supplements support healthy blood flow. Additionally, you can take LIFE FORCE, Source Naturals’ best selling multiple. Systemic enzymes such as nattokinase are a new class of natural compounds that can have a significant impact on your cardiovascular, joint and immune health. Source Naturals is pleased to partner with your local health food stores and participating health professionals – the only places where you can find these natural health advances – to bring you NATTOKINASE. Try this ancient Japanese secret to support your cardiovascular health today.

References
Sumi, H. et al. (1990). Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematologica. (84): 139-143. Fujita, M. et al. (1995). Transport of nattokinase across the rat intestinal tract. Biological and Pharmaceutical Bulletin 18(9): 1194-1196. Yamamoto, K. et al. (2002). Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals. Proceedings of the National Academy of Sciences. 99(2): 890-895.

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VitaNet ®
VitaNet ® Staff

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Heart Science - A Five-Tiered Approach to Heart Health ...

Date: June 02, 2005 12:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Heart Science - A Five-Tiered Approach to Heart Health ...

Heart Science 30 tabs

Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available.

Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health

Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for
1) generating energy,
2) decreasing harmful homocysteine levels,
3) fighting oxidized cholesterol,
4) maintaining the heart’s electrical rhythm, and
5) protecting artery and capillary linings.

Energy Generators for An Energetic Organ

Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply.

There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently.

CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10

Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound.

Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21

HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells.

Homocysteine Regulators

B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization.

The Dangers of Oxidized LDL Cholesterol

While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL.

When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse.

The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes.

Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol.

Cholesterol Fighters

Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits:

• Beta Carotene, a plant pigment, is the naturally occurring precursor to Vitamin A. When the body takes in high enough amounts of Beta Carotene, this lipid-soluble free radical scavenger concentrates in circulating lipoproteins and atherosclerotic plaques, where it performs its antioxidant functions. Beta Carotene is particularly unique and powerful as an antioxidant because it is capable of trapping a very toxic form of di-oxygen, called singlet oxygen, which can result in severe tissue damage. Beta Carotene is one of the most efficient quenchers of singlet oxygen thus far discovered. Six tablets of HEART SCIENCE provide an unprecedented 45,000 IU of Beta Carotene!

• Vitamin C is found in plasma, the watery component of blood, where it functions as a potent antioxidant. In addition to strengthening artery linings through collagen manufacture, Vitamin C is involved in the regeneration of Vitamin E within LDL particles. Vitamin C also plays an important role in the conversion of cholesterol into bile acids by the liver, a crucial step in reducing blood cholesterol levels. Once converted into bile acids, and then into bile salts, cholesterol can be excreted from the body, preventing build-up. Supplementation with Vitamin C may lower levels of LDL cholesterol and increase those of HDL cholesterol.25 It may also have a part in actually removing cholesterol deposits from artery walls — good news for people who are already experiencing plaque buildup.25 Each daily dose of HEART SCIENCE provides 1,500 mg of Vitamin C in its bioactive mineral ascorbate form.

• Vitamin E, together with Beta Carotene, protects lipids from free radical attack. It is the major antioxidant vitamin that is carried in the lipid fraction of the LDL particle, where it protects the LDL particle from damaging oxidation. Within an LDL particle, one molecule of Vitamin E has the ability to protect about 200 molecules of polyunsaturated fatty acids from free radical damage! Vitamin E also aids in protecting the heart by interfering with the abnormal clumping of blood cell fragments, called platelets, within blood vessels.4 It has been shown to inhibit the formation of thromboxanes and increase the production of prostacyclins, which together decrease abnormal platelet aggregation.11 A high potency of Vitamin E — 400 IU’s — is included in six tablets of HEART SCIENCE in the natural d-alpha succinate form, recognized by scientific researchers to be the most absorbable form!

• Selenium is an important mineral which has only recently gained attention. When incorporated into the enzyme Glutathione Peroxidase, it has highly powerful free radical-scavenging abilities, and has been shown to work synergistically with Vitamins A, C, and E. An essential mineral, Selenium used to be derived from eating foods grown in Selenium-rich soil. However, modern agricultural practices have depleted soil of its natural Selenium content, leaving many Americans deficient in this vital nutrient. Several epidemiological studies show that the incidence of advanced fatty deposits in blood vessels is much greater in individuals living in geographic areas of the United States and other parts of the world where the Selenium content of the soil is very low.27

• Proanthodyn,™ an extract of grape seeds, is being called the most powerful antioxidant yet discovered. This highly potent, water-soluble bioflavonoid contains between 93-95% proanthocyanidins, the highest concentration of any nutrient available today. The protective actions of proanthocyanidins may help to prevent the development of plaque in artery walls by inhibiting the free radicals which are produced during the oxidation of cholesterol. The optimal daily amount (100 mg) of Proanthodyn is included in six tablets of HEART SCIENCE. In addition to the protective actions of antioxidants, several other nutrients can contribute to healthier cholesterol ratios.

• Chromium is a trace mineral which functions to aid the entrance of glucose into cells. Six tablets of HEART SCIENCE provide 300 mcg of Chromium in the form of Chromate® Chromium Polynicotinate and Chromium Picolinate — the most bioactive forms of Chromium. Not many people are familiar with the vital role Copper plays in the body. This trace mineral is found in all tissues of the body, and is particularly concentrated in the heart. Copper is part of several enzymes, and, in this capacity, is necessary for the development and maintenance of the cardiovascular system, including the heart, arteries, and other blood vessels. Because of its role in elastin production, Copper deficiency can severely damage blood vessels and heart tissue. In fact, researchers have found an inverse relationship between Copper status and increased risk for heart damage.10

• L-Proline and L-Lysine are two natural amino acids which show exciting promise in helping to prevent fatty deposits in blood vessels. Researchers have recently identified a particle associated with LDL called apoprotein (a) which is believed to be a main culprit in plaque development. 17 Scientific investigation has revealed that the lipoprotein (a) particle has an adhesive quality that makes the lipoprotein fat globule stick inside blood vessels. The sticky fat globules accumulate, leading to fatty deposits in blood vessels and the subsequent clogging of the arteries. L-Proline and L-Lysine tend to form a barrierlike layer around the apoprotein (a) particle, helping to push it away from the blood vessel wall, and impeding deposit.21

The Regulating Trio

Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings.

• Magnesium is one of the single most important nutrients for maintaining a healthy heart. It plays an extremely vital role in maintaining the electrical and physical integrity of the heart muscle. It has been well established that Magnesium deficiency predisposes humans to serious disruptions of normal cardiac rhythm. One theory is that because Magnesium has a relaxing effect on muscle tissue, inadequate Magnesium stores may make the coronary arteries more susceptible to muscle spasm.10 Too little Magnesium can cause a Calcium/Magnesium imbalance, which can lead to the influx of too much Calcium into heart cells, and potentiate spasms in heart tissue. Another point for consideration is that because it relaxes the blood vessels, Magnesium keeps these vessels open, allowing for maximum blood flow to the heart. Magnesium also has the unique ability to stop unnecessary blood clotting by helping to reduce platelet adhesion.31 Blood clots are naturally produced by the body as a protective device to stop excessive blood flow when the body is injured. The clotting response happens when the body senses that the normally smooth blood vessel linings are rough, indicating that there is a cut. However, sometimes the body mistakes the rough surface of plaque-covered arteries as cuts, and creates unnecessary blood clots. Or, if a high fat meal has just been eaten, tiny fat globules called chylomicrons enter the bloodstream and can cause platelets to become abnormally sticky, possibly creating clots. When these clots flow through the bloodstream and reach a part of the artery which has plaque buildup, normal blood flow is blocked, and the amount of blood which reaches the heart is severely compromised. Magnesium is also crucial for the entrance of Potassium — a key mineral for many bodily functions — into the cells. Even if the body’s Potassium stores are high, without enough Magnesium, the Potassium will not be able to enter the cells and be utilized by the body. 300 mg of Magnesium (75% of the U.S.RDA) are contained in each daily dose of HEART SCIENCE. Along with Magnesium, Potassium helps to regulate normal heartbeat and blood pressure, and is necessary for the contraction and relaxation of muscle tissue. Potassium and Sodium are present in all body fluids; Potassium is found primarily within cell fluids, while Sodium is usually present in fluids surrounding cells. Together, they function to maintain the normal balance and distribution of fluids throughout the body. The body ideally should have a Potassium/Sodium balance of about 1:1; however, because the body holds onto Sodium, yet eliminates Potassium quickly, it is important that the dietary ratio of these two minerals be at least 3:1. Unfortunately, the typical American diet, with its emphasis on processed, salty (Sodiumrich) foods and lack of fresh fruits and vegetables, severely alters the body’s natural Potassium/ Sodium balance. Diets in the United States are extremely high in Sodium — sometimes containing as much as 15 times the recommended daily intake! A high Sodium/low Potassium diet interferes with the normal regulation of heartbeat and blood pressure, and has been linked with elevated blood pressure.25 Taurine is an amino acid which helps normalize electrical and mechanical activity of the heart muscle by regulating Potassium flux in and out of the heart muscle cells.

Artery Lining Protectors

Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6

Capillary Strengtheners

Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart.

Heart Smarts

The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care.

Source Naturals HEART SCIENCE™

The Five Tiered Approach to Heart Health
Six tablets contain:
Vitamins and Minerals %USRDA
Pro-Vit A (Beta Carotene) 45,000 IU 900%
Vit B1 (Thiamine) 50 mg 3333%
Vit B3 (Inositol Hexanicotinate) 500 mg 2500%
Vit B6 (Pyridoxine HCl) 25 mg 1250%
Coenzyme B6 (Pyridoxal-5-Phosphate)
25 mg yielding: 16.9 mg of Vit B6 845% (Total Vitamin B6 Activity) (41.9 mg) (2095%)
Vit B12 (Cyanocobalamin) 500 mcg 8333%
Folic Acid 800 mcg 200%
Vit C (Magnesium Ascorbate) 1500 mg 2500%
Vit E (d-alpha Tocopheryl Succinate) 400 IU 1333%
Chromium (ChromeMate® †Polynicotinate-150 mcg & Chromium Picolinate††-150 mcg) 300 mcg *
Copper (Sebacate) 750 mcg 37.5%
Magnesium (Ascorbate, Taurinate & Oxide) 300 mg 75%
Potassium (Citrate) 99 mg *
Selenium (L-Selenomethionine) 200 mcg *
Silicon (From 400 mg of Horsetail Extract) 13mg *
* U.S. RDA not established.
Other Ingredients and Herbs
Coenzyme Q10 (Ubiquinone) 60 mg
L-Carnitine (L-Tartrate) 500 mg
Hawthorn Berry Extract 400 mg
Proanthodyn™ (Yielding 95 mg of Proanthocyanidins from grape seed extract) 100 mg
L-Proline 500 mg
L-Lysine (HCl) 500 mg
NAG™ (N-Acetyl Glucosamine) 500 mg
Bromelain (2000 G.D.U. per gram) 1200 G.D.U.
Taurine (Magnesium Taurinate) 500 mg
Horsetail Extract (Yielding 31 mg of Silica) 400 mg
Inositol (Hexanicotinate) 50 mg

Reference:
1. Azuma, J., Sawamura, A., & Awata, N. (1992, Jan). “Usefulness of Taurine... and its Prospective Application.” Japanese Circulation Journal, 56(1), 95-9.
2. Blazso, G and Gabor, M. (1980). “Odema-inhibiting Effect of Procyanidin.” Acta Physiologica Academiae ScientiarumHungaricae, 56(2), 235-240.
3. Brattstrom, E. L, Hultberg, L. B., & Hardebo, E. J. (1985, Nov.). “Folic Acid Responsive Postmenopausal Homocysteinemia.” Metabolism, (34)11, 1073-1077.
4. Colette, C., et al., (1988). “Platelet Function in Type I Diabetes: Effects of Supplementation with Large Doses of Vitamin E.” American Journal of Clinical Nutrition, 47, 256-61.
5. England, M. R., et al. (1992, Nov. 4). “Magnesium Administration and Dysrhythmias...A Placebo-controlled, Double-blind, Randomized Trial.” Journal of the American Medical Association, 268(17), 2395-402.
6. Felton, G. E. (1980, Nov.). “fibrinolytic and Antithrombotic Action of Bromelain...” Medical Hypotheses (11)6, 1123-33.
7. Grundy, S. M. (1993, Apr.). “Oxidized LDL and Atherogenesis: Relation to Risk Factors...” Clinical Cardiology, 16 (4 Suppl.I), I3-5.
8. Hano, O. et al. (1994, June). “Coenzyme Q10 Enhances Cardiac Functional and Metabolic Recovery and Reduces Ca2+ Overload during Postischemic Reperfusion.” American Journal of Physiology, 266(6 Pt 2), H2174-81.
9. Heineke, et al. (1972). “Effect of Bromelain (Ananase) on Human Platelet Aggregation.” Experientia V. 23, 844-45.
10. Hendler, S. S. (1991). The Doctors’ Vitamin and Mineral Encyclopedia. NewYork: Fireside.
11. Jandak, et al. (1988, Dec. 15). “Reduction of Platelet Adhesiveness by Vitamin E Supplementation in Humans.” Thrombosis Research 49(4), 393-404.
12. Jialal, I., et al. (1991, Oct. 15). “Beta-Carotene Inhibits the Oxidative Modification of Low-density Lipoprotein.” Biochimica et Biophysica Acta, 1086(1), 134-8.
13. Jialal, I. & Fuller, C. J. (1993, Apr. 16). “Oxidized LDL and Antioxidants.” Clinical Cardiology, Vol. 16 (Suppl. I), I6-9.
14. Jialal, I., & Grundy, S.M. (1991, Feb.). “Preservation of the Endogenous Antioxidants in Low Density Lipoprotein...” Journal of Clinical Investigation, 87(2), 597-601.
15. Kamikawa, T., et al. (1985). “Effects of Coenzyme Q10 on Exercise Tolerance...” American Journal of Cardiology, 56, 247-251.
16. Kosolcharoen, P., et al. (1981, Nov.). “Improved Exercise Tolerance after Administration of Carnitine.” Current Therapeutic Research, 753-764.
17. Lawn, R. (1992, June). “Lipoprotein (a) in ...” Medicine, 12-18.
18. Mortensen, S.A.et al. (1985). “Long-term coenzyme Q10 therapy: A major advance in the management of resistant myocardial failure.” Drugs Exp. Clin. Res., 11(8), 581-93.
19. Nayler, W. G. (1980). “The Use of Coenzyme Q10 to Protect Ischemic Heart Muscle.” In: Yamamura Y., Folkners K., Ito Y., eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 2, Amsterdam: Elsevier/North-Holland Biochemical Press, 409-425.
20. Press, R.I., & Geller, J., (1990, Jan.). “The Effect of Chromium Picolinate on Serum Cholesterol and Apolipoprotein Fractions in Human Subjects.” Western Journal of Medicine, 152, 41-45.
21. Rath, M. (1993). Eradicating Heart Disease. San Francisco: Health Now.
22. Rossi, C. S., & Silliprandi, N. (1982, Feb.). “Effect of Carnitine on Serum HDL Cholesterol: Report of Two Cases.” Johns Hopkins Medical Journal, 150(2), 51-4.
23. Schwarz, K. (1977, Feb. 2). “Silicon, Fibre, and Atherosclerosis.” The Lancet, 454-456.
24. Selhub, J., et al. (1995, Feb. 2). “Association Between Plasma Homocysteine Concentrations and Extracranial Carotid-artery Stenosis.” New England Journal of Medicine, 332(5), 286-291.
25. Somer, Elizabeth. (1992). The Essential Guide to Vitamins and Minerals. New York: Health Media of America.
26. Stampfer, M. J., et al. (1992, Aug. 19). “A Prospective Study of Plasma Homocyst(e)ine...” Journal of the American Medical Association, 268(7), 877-881.
27. Suadicani, P., Hein, H. O., & Gyntelberg, F. (1992, Sept.). “Serum Selenium Concentration...in a Prospective Cohort Study of 3000 Males.” Atherosclerosis, 96(1), 33-42.
28. Thomas, C. L. (Eds.). (1985). Taber’s Cyclopedic Medical Dictionary, (15th ed.). Philadelphia: F.A. Davis Company.
29. Tsuyusaki, T. et al. “Mechanocardiography of ischemic or hypertensive heart failure,” in Yamaura Y et al., Biomed. & Clin. Aspects of Coenzyme Q.2 Amsterdam, Elsevier/North Holland Biomedical Press, 1980, 273-88.
30. Verlangieri, A. J., & Stevens, J. W. (1979). “L-Ascorbic Acid: Effects on Aortic Glycosaminoglycan S Incorporation...” Blood Vessels, 16(4), 177-185.
31. Werbach, M. R. (1987). Nutritional Influences on Illness: A Sourcebook of Clinical Research. New Canaan: Keats Publishing, Inc.
32. White, R.R., et al. (1988, Jul-Aug.). “Bioavailability of 125I Bromelain after Oral Administration to Rats.” Biopharmaceutics and Drug Disposition, 9(4), 397-403.
33. Whitney, E. N., Hamilton, Nunnelly, E. M. (1984). Understanding Nutrition, (3rd ed.). St. Paul: West Publishing Company.
34. Willard, Terry, Ph.D. (1992). Textbook of Advanced Herbology. Calgary, Alberta, Canada: Wild Rose College of Natural Healing.
35. Xiang, H., Heyliger, et al. (1988, Nov.). “Effect of Myo-inositol and T3 on Myocardial Lipids and Cardiac Function in Streptozocin-induced Diabetic Rats.” Diabetes, 37(11), 1542-8.

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VitaNet ®
VitaNet ® Staff

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Garlic Supplementation and Lipoprotein Oxidation Susceptibility

Date: May 12, 2005 01:01 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Garlic Supplementation and Lipoprotein Oxidation Susceptibility

Garlic Supplementation and Lipoprotein Oxidation Susceptibility

Author:
Phelps S, Harris W

Source:
LIPIDS. 1993; 28(5):475-477.

Abstract:
Interventions which make serum lipoproteins less susceptible to oxidation may be antiatherogenic. The antioxidant properties of garlic which have been demonstrated in vitro led us to investigate the effects of garlic supplements on lipoprotein oxidation susceptibility in humans. Ten healthy volunteers were given 600 mg/d of garlic powder (6 tablets of Kwai) for two weeks in a placebo-controlled, randomized, double-blind crossover trial. We found that although serum lipid and lipoprotein levels were not lowered in this short time period, the ex vivo susceptibility of apolipoprotein B-containing lipoproteins to oxidation was significantly decreased (34%). Because garlic has been reported to beneficially affect serum lipid levels, platelet function, fibrinolysis and blood pressure, this additional effect of retarding lipoprotein oxidation may contribute to the potential antiatherosclerotic effect of garlic.
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Nattokinase: Food For Cardiovascular Health

Date: May 10, 2005 10:13 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Nattokinase: Food For Cardiovascular Health

Say it Ain't Soy!

Yes, but this soybean is different! What makes it different is simple. after hours of fermentation, the boiled soybean metamorphose to an ancient medicinal food called "Natto" pronounced "Nah'-Toe." Natto may just be the "perfect food," producing 18 valuable amino acids and an enxyme natokinase that may challenge the pharmaceutical industry's best "blood-clot busters." Natto, which has recently attracted attention throughout the world, is the third most popular type of fermented soybean in the japanese diet. Japan has the highest average longevity in the world, which may partly be attributed to a high consumption of natto.

When compared with ordinary soybeans, the natto produces more calories, protein, fiber, calium, potassium and vitamin B2. Its high protein and economical price in terms of protein per gram has earned it the sobriquet. "Hata-ke no niko," a meat of the field. This nickname appears well deserved, as in comparison with an equivalent amount of beef, natto has slighly less protein (16.5 grams to 21.2 grams),but contains more carbohydrates and fiber, and is also higher in calcium, phosphorous, iron and vitamin B2. Plus, it has nearly double the calcium and far more vitamin E to boot.

According to legend, the first person to originate traditional Japanese natto was the famous warrior Yoshiie Minamoto during the Heian era of Japanese history (794 - 1192 A.D.). The horse was extremely important to the Japanese samurai warrior of the period, and great care was given to provide suitable provisions for the horses when armies were on the move. Typically, boiled soybeans were cooled down, dried in teh sun and packed immediately in rice straw bags for transport with the army. If the army was on a rapid deployment, the boiled soybeans were packed hastely into the rice straw bags with out cooling or drying. The rice straw just happened to contain a harmless and naturally occuring microorganism, Bacillus Subtilis that fermented the soybeans and producted natto with its characteristic sticky texture.

Initially, the soybeans were presumed to have spoiled until yashiie minamoto observed that his horses were "picky eaters" and demonstrated a preference for the "spoiled" Soybeans or natto. One day, Minamoto demonstrated tremendous courage and dipped his fingers into the seemingly rotten goo. To his astonishment, the fermented soybeans were not only edible but had a distinct umami flavor. Minamoto was responsible for introducing natto to northwestern Japan, where he ruled. To this day natto is especially popular in that region of Japan as a folk remedy for fatigue, beriberi, dysentery, heart and vascular deseases.

The most distinctive features of natto are the adheasive surrounding the soybeans and the strong flavor. The sticky material has been shown to consist of poly-g-glutamic Acid (D and L) and polysaccharides (Levan-form fructan), and the strong "cheese like" flavor is due to the presence of pyrazine. These features sometimes make it hard for some people, especially people from other countries, to accept natto; however, these are the main factors which give natto the outstanding properties. Natto, which has recently attracted attention throughout the world, is a familiar part of the Japanese diet.

Technical Aspects of Nattokinase:

Nattokinase produces a prolonged action in two ways: it prevents the formation of thrombi and it dissolves existing thrombus. Nattokinase orally administrated to twelve healthy adults indicated elevations in the breakdown products of the fibrin and the ability of the blood to break down fibrin called eugobulin fibrionlytic activity (EFA). These results suggest the ability of nattokinase to accelerate fibrinolysis in the blood for a prolonged period of time. FDP levels in the adults drastically increased 4 hours after the administration of the nattokinase, indicating that fibrin within the blood vessels is gradually being disolved with repeated intake of nattokinase. By measuring the EFA & FDP levels, the activity of nattokinase has been determined to last for 8 to 12 hours. An additional parameter for confirming the action of NATTOKINASE following oral administration is a rise in blood levels of tissue plasminogen activator (TPA) antigen, which indicates a release of TPA from the endothelial cells and/or the liver and the endogenous production of plasmin (The body's blood clotting buster).6,7

In 1995, researchers from Miyazki Medical College and Kurashiki Unerversity of science and arts in Japan studied the effects of nattokinase on the blood preasure in both animals and human subjects. In addition, the researchers confirmed the presence of inhibitors of angiotensin converting enzyme (ACE) within the test extract, which consisted of 80% ethanol extract of lyophilized viscous materials of natto. ACE causes blood vessels to narrow and blood pressure to rise - by inhibiting ACE; nattokinase has a lowering effect on blood pressure.1,2

The same natto extract was then tested on human volunteers with high blood pressure. Blood pressure levels were measured after 30 grams of lyophilized extract (Equivalent to 200 grams of natto food) was administered orally for 4 consecutive days. In 4 out of 5 volunteers, the systolic blood pressure (SBP) decreased on average from 173.8+- 20.5 mmHg to 154.8+-12.6 mmHg. Diastolic blood pressure (DBP) decreased on average from 101.0+- 11.3 mmHg to 91.2+- 6.6 mmHg. On average, this data representes a 10.9 percent drop in SBP and a 9.7 precent drop in DBP. 1,2,6

Disclaimer: The above artical is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competen t licensed professional health care provider. The information in this artical has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any desease.

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Estro-3 60 Vegetarian Capsules

Date: May 07, 2005 10:30 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Estro-3 60 Vegetarian Capsules

Estro-3 Dietary Supplement to help restore Balance Naturalls. More and more women rely on plant derived phytoestrogens as a natural way to help support a woman's transition. The Solaray® brand is proud to introduce a highly advanced and innovative proprietary blend of licorice, pomegranate, and hops with a Guaranteed Potency(GP) amount of phytoestriol, phytostrone, and phytoestrodiol three phytoestrogens that are naturally occuring.

Trust in the Power of Three!

Most plant estrogens (Phytoestrogen) products contain genistein and daidzein. Estro-3 dietary supplement provides three sources of novel phytoestrogens-- phytoestriol, phytoestrone, and phytoestradiol.

Support herbs

Butcher's Broom is an herb that has been used traditionally to provide nutritive support for healthy, normal blood circulation.

Indole-3-carbinol is a sulfur-based compound from cruciferous vegetables that breaks down into metabolites that may play a beneficial role in supporting estrogen metabolism down various pathways and may play a support role in normal, healthy cell function.

Nattokinase is a fibrinolitic enzyme produced from natto, a traditional japanese cheese-like substance made from fermented soybean, that may help provide nutritive support of normal blood flow.

Estro-3 balance estrogen naturally

Darrell -- VitaNet ® VitaNet ® Staff

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Search Term: " fibrin "

Messages 1-40 from 40 matching the search criteria.

How to Cleanse the Spike Protein Out of the Body	Darrell Miller	6/11/24
Support Healthy Circulation and Arterial Function with Benfotiamine!	Darrell Miller	11/21/16
Facts about Curamin and its working formula.	Darrell Miller	3/30/14
Health benefits of Bromelain and its mechanism of fighting inflammation	Darrell Miller	4/20/13
The working principle of Curamin	Darrell Miller	3/22/13
What Is 2000fu In Nattokinse?	Darrell Miller	12/29/12
Does Curamin work?	Darrell Miller	12/22/12
All about curamin	Darrell Miller	12/13/12
Can Serrapeptase Help Break Down Cholesterol?	Darrell Miller	12/1/12
What Are The Health Benefits Of Nattokinase?	Darrell Miller	5/12/12
Serrapeptidase: Natural NSAID	Darrell Miller	3/27/12
8 Major Benefits of Nattokinase	Darrell Miller	2/18/12
What Supplements Are Useful In Combating Blood Clots?	Darrell Miller	10/4/11
How Does Serrapeptidase Support A Healthy Immune System, Regulate Inflammation, And More?	Darrell Miller	9/1/11
How Does Nattokinase Help Improve Cardiovascular Health	Darrell Miller	4/29/11
Bromelain Supplements why?	Darrell Miller	11/6/10
Thrombophlebitis	Darrell Miller	4/15/09
Bromelain Enzymes	Darrell Miller	5/1/08
Looking For A Calcium But Not Sure Which Is Best For You?	Darrell Miller	11/2/07
Serrapeptase a modern marvel in cardiac research!	Darrell Miller	4/15/06
Rutozym - Systemic Enzyme Supplement with Nattokinase	Darrell Miller	2/22/06
New Frontiers in Enzyme Supplementation	Darrell Miller	2/16/06
Policosanol and Nattokinase together!	Darrell Miller	12/31/05
Nattokinase Fact Sheet	Darrell Miller	12/8/05
Nattokinase - Systemic Enzyme for Healthy Circulation	Darrell Miller	8/3/05
Serrapeptase - For Serr-ious Sinus Support	Darrell Miller	7/11/05
Quercetin and Bromelain - for better health.	Darrell Miller	7/4/05
REFERENCES	Darrell Miller	6/25/05
GARLIC AS A NATURAL BLOOD THINNER	Darrell Miller	6/25/05
HIGH BLOOD PRESSURE AND GARLIC THERAPY	Darrell Miller	6/25/05
GARLIC (allium sativum)	Darrell Miller	6/25/05
ENDNOTES	Darrell Miller	6/23/05
Bromelain Sinus Ease - Nature's Life	Darrell Miller	6/16/05
Garlic for the Ages - eat garlic because it's good for your heart...	Darrell Miller	6/13/05
Hearty Nutrients	Darrell Miller	6/10/05
NATTOKINASE - A Systemic Enzyme for Healthy Circulation ...	Darrell Miller	6/4/05
Heart Science - A Five-Tiered Approach to Heart Health ...	Darrell Miller	6/2/05
Garlic Supplementation and Lipoprotein Oxidation Susceptibility	Darrell Miller	5/12/05
Nattokinase: Food For Cardiovascular Health	Darrell Miller	5/10/05
Estro-3 60 Vegetarian Capsules	Darrell Miller	5/7/05

How to Cleanse the Spike Protein Out of the Body

Date: June 11, 2024 05:22 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: How to Cleanse the Spike Protein Out of the Body

How to Cleanse the Spike Protein Out of the Body

The spike protein has recently become a topic of major concern, especially in light of the COVID-19 pandemic. Understanding what it is and how to manage its effects is crucial for overall health. In this article, we will explore what the spike protein is, its possible impacts on the body, and how natural substances like curcumin, bromelain, and nattokinase can help reduce its presence in the body.

Understanding the Spike Protein

The spike protein is a key component of the novel coronavirus SARS-CoV-2, which causes COVID-19. This protein is responsible for allowing the virus to enter human cells and initiate infection. The spike protein binds to receptors on the surface of human cells, facilitating the virus's entry and subsequent replication within the body. While the immune system typically destroys these proteins, lingering spike proteins can pose health risks, including inflammation and abnormal blood clotting.

The Role of Curcumin

Curcumin is a bioactive compound found in turmeric, a spice widely used in cooking and traditional medicine. This compound has powerful anti-inflammatory and antioxidant properties, making it a beneficial ally in combating various health issues, including the presence of spike proteins.

How Curcumin Works

Curcumin works by modulating several biochemical pathways in the body. One of its primary functions is to inhibit pro-inflammatory cytokines and enzymes that contribute to inflammation. Additionally, curcumin boosts the activity of antioxidant enzymes, which helps neutralize harmful free radicals. By reducing inflammation and oxidative stress, curcumin can help minimize the damage caused by spike proteins.

How to Use Curcumin

To harness the health benefits of curcumin, it's best to incorporate turmeric into your diet or take curcumin supplements. Curcumin supplements often come in combination with piperine, a compound found in black pepper that enhances curcumin absorption. Curcumin is also combined with turmeric oil to enhance its absorption, consider using either one in supplement form to help the body rid itself of the spike protein.

The Benefits of Bromelain

Bromelain is a mixture of enzymes found in pineapples. Known for its anti-inflammatory and immune-modulating properties, bromelain can also help address the lingering effects of spike proteins.

How Bromelain Works

Bromelain works by breaking down proteins and minimizing inflammation. It inhibits the production of pro-inflammatory cytokines, helping to reduce swelling and discomfort. The proteolytic (protein-digesting) enzymes in bromelain can also help to break down and clear spike proteins from the body.

How to Use Bromelain

Bromelain can be consumed through fresh pineapple or as a dietary supplement. If you opt for supplements, ensure that you follow the recommended dosage and consult your healthcare provider beforehand.

The Power of Nattokinase

Nattokinase is an enzyme extracted from natto, a traditional Japanese dish made from fermented soybeans. This enzyme has gained attention for its ability to support cardiovascular health and promote the breakdown of fibrin, a protein involved in blood clotting.

How Nattokinase Works

Nattokinase helps to break down fibrin in the blood vessels, thereby preventing clots from forming. Additionally, this enzyme supports the degradation of spike proteins, potentially reducing the risk of clot-related issues. Nattokinase also helps to improve blood flow and enhance overall cardiovascular health.

How to Use Nattokinase

Nattokinase is available in supplement form. When choosing a nattokinase supplement, look for a product with a high level of activity units, which measure enzymatic activity. Generally, nattokinase comes in 2000FU, and is taken 2 - 3 times daily.

Combining Natural Remedies

Combining curcumin, bromelain, and nattokinase can provide a comprehensive approach to managing spike proteins in the body. Each of these natural substances works in different ways to reduce inflammation, enhance immune response, and clear harmful proteins. However, it's essential to adopt a holistic approach to health that includes a balanced diet, regular exercise, proper hydration, and adequate sleep.

Diet and Lifestyle Tips

Balanced Diet: Incorporate a variety of fruits, vegetables, lean proteins, and whole grains to provide your body with essential nutrients.
Hydration: Drink plenty of water to support overall bodily functions and help flush out toxins.
Exercise: Engage in regular physical activity to support cardiovascular health and improve circulation.
Sleep: Ensure you get adequate rest to allow your body to repair and regenerate.

Additional Recommendations

Consult a Healthcare Provider: Always seek professional medical advice before starting any new supplement or treatment plan.
Monitor Your Health: Keep track of your health and any changes you notice, and report them to your healthcare provider.
Stay Informed: Continue to educate yourself about the latest developments in health and wellness.

Maintain Good Health

Understanding and managing the presence of spike proteins in the body is vital for maintaining overall health. Natural compounds like curcumin, bromelain, and nattokinase offer promising benefits in reducing the harmful effects of these proteins. By incorporating these substances into your diet and following a holistic approach to wellness, you can support your body's natural defences and promote optimal health. So, it is essential to prioritize healthy habits and consider incorporating natural remedies as part of a comprehensive approach to maintaining good health.

Final thoughts

Spike proteins play a significant role in the infection process of viruses, making it crucial to address their lingering effects in the body. Natural compounds like curcumin, bromelain, and nattokinase offer promising benefits in reducing inflammation and clearing spike proteins from the body. Additionally, adopting a balanced diet and lifestyle can support the effectiveness of these natural remedies in promoting overall health. By taking a holistic approach to wellness, we can work towards managing spike proteins and supporting our

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Support Healthy Circulation and Arterial Function with Benfotiamine!

Date: November 21, 2016 10:50 PM
Author: Darrell Miller
Subject: Support Healthy Circulation and Arterial Function with Benfotiamine!

Benfotiamine is a derivative nutrient of thiamine (vitamin B1). Usually, many people suffering from peripheral neuropathy lack this crucial nutrient. Thiamine, Vitamin B1, is highly required for the nervous system to keep functioning properly. Maintaining adequate levels of Thiamine through diet alone is hard. Benfotiamine works to nourish the nerves and reverse the effects of peripheral neuropathy. It helps to support blood circulation, enhance arterial function and healthy blood vessels.

Increases blood circulation and vessel health

Benfotiamine helps to increase the rate of blood flow, especially for those patients suffering from low blood circulation. It is also required for the health of the nervous system and is required for the biosynthesis of a number of cell constituents, including certain neurotransmitters. Just like Vitamin B1, Benfotiamine demonstrated itself as a miracle worker when somebody suffering severely from beriberi got on his feet within hours after being injected with the nutrient. Since then, it has been performing the same "miracle" without fail.

Benfotiamine also assists mental health, particularly warding off depression while facilitating memory functions and learning. It's deficiency will no doubt bring back the dreaded beriberi, while minor deficiencies will be manifested in the human body as extreme fatigue, irritability, constipation, edema and an enlarged liver. Forgetfulness, gastrointestinal disturbances, heart changes, irritability, and breathing difficulties are also common symptoms.

Promotes arterial function

Benfotiamine has been proven to improve the structural integrity of the veins and the entire circulatory system. Usually, people with varicose veins have an increased tendency to develop fibrin deposits in the tissue surrounding the affected veins. This causes the skin to become hard and lumpy. There is a decreased ability to break down fibrin, a compound involved in clot formation, thus an increased risk of the formation of a thrombus which may potentially cause life-threatening complications. Benfotiamine nutrient helps to promote fibrin breakdown hence promote the functioning of the arteries while enhancing the flood of blood.

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Facts about Curamin and its working formula.

Date: March 30, 2014 01:14 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Facts about Curamin and its working formula.

Benefits of curcumin

curcumin powder It is very normal to experience pain and inflammations however, curamin is the answer to any pain problem. What is curamin? It can be described as a blend of all-natural components comprising of curcumin, Boswellia, curcuminoids, nattokinase and DLPA (dl-phenylalanine). Curcumin has been researched and found to have a broad healing platform, that is, anti cancer, anti-inflammatory, anti-oxidant, anti bacterial and anti-fungal. During post-surgery, it has been proven to ease inflammation and in addition to that, reducing inflammation and swelling in arthritic conditions. Nattokinase is nutrient element in curamin which is an enzyme. The enzyme functions in that it helps breakdown blood clots as they can be painful and moreso, helps in relieving blood pressure.

Inflammations should be well taken care of as research says that, the pains are responsible for all kinds of serious sicknesses such as cancer and painful conditions such as arthritis. The enzyme nattokinase, is very important in relieving inflammations by enhancing circulation in the body thus allowing compounds such as boswellia, pain killer endorphins and curcumin to get to the areas where they are needed most. In addition,it enhances balance of fibrinogen in the body which is associated with muscle damage. Curamin also contains a component by the name DLPA which works in an interconnected mode and furthermore improving moods. Boswellia is termed as a traditional herb which relieves pain by reducing inflammation.
How does curamin work? Through the unique combination of the several components the product comes up with mechanisms that support the anti-inflammatory response within the body. Inflammatory compounds within the the body are inhibited by a combined formula of boswellia and curcumin. Nattokinase is responsible for increased circulation so as to transport beneficial components to areas of need. DLPA is responsible for that positive mood to ensure quick recovery.

Recommended dosage

Two capsules, two times a day is the most appropriate dosage to clients. The manufacturer warns that eight capsules should not be exceeded in 24 hours.

Sources

//www.needs.com/products
//www.medicalpublications.org/curamin.htm

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Health benefits of Bromelain and its mechanism of fighting inflammation

Date: April 20, 2013 09:54 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Health benefits of Bromelain and its mechanism of fighting inflammation

Bromelain is a blend of enzymes found in the juice and the stems of pineapples and is often used as a health supplement to assist in various disorders and enhance overall health. Here are the health benefits of Bromelain.

Improved Heart health

Bromelain functions as a blood thinner by breaking down the fibrins thus helps prevent blood clotting. It allows blood to move more freely throughout the circulatory system. Thinner blood is linked with lower possibilities of stroke, cardiac arrest and other heart problems.

Improved Breathing conditions

Bromelain is linked to improved breathing conditions that occur as a result of thicker mucus like asthma. It has similar effects on mucus as it has on blood thus making mucus thinner and thus does not clog the bronchial tubes.

Improved Immunity

It serves as an immunity booster and helps certain immunity boosting receptors within the body. As a result it fortifies the immune response by improving the response of body's front-line immune defense called the T-cells.

Improved digestion

If the pancreas is not very active, it may produce insufficient quantities of enzymes, making the food we eat just getting digested partially. Consuming a bromelain supplement might help to cure any resulting digestive complaints like stomach upset, heartburn, diarrhea or indigestion. It is especially effective when used in in conjunction with other enzymes such as amylase and lipase because of its protease functions.

Wound healing

An external application of bromelain might help getting rid of undesirable skin tissues in the third-degree burns. Bromelain could also reduce inflammation due to insect bites and their stings.

Alleviates Sinusitis

Bromelain helps decreasing congestion and the cough that comes with sinusitis. Its anti-microbial attributes may wipe out viruses and bacteria associated with sinus infections.

Relieves varicose veins and Hemorrhoids

Bromelain is used as a complementary medicine in treating chronic venous insufficiency, hemorrhoids and varicose veins.

Enhanced Acid-alkaline balance

Bromelain can help in balancing the acidity and also the alkalinity in the small intestine. The anti-bacterial effects of bromelain helps relieving bacteria-related diarrhea connected with E. coli attacks and inflammatory bowel disease.

Bromelain and Inflammation

While inflammation aids mending the entire body during an injury, excessive swelling can result in health complications and speed up aging. Bromelain is beneficial in treating inflammation. The mechanism of how bromelain fights inflammation involves the inhibition of many bio-chemical responses and reactions that induce inflammation. Treatment with bromelain manages and regulates the activity of various bio-chemical messengers referred to as cytokines in our body. These cytokines are the chemical substances that trigger inflammation. By inhibiting the activity of cytokines, bromelain reduces the impulses that induce an inflammatory reaction.

Bromelain also decreases the deposition of kinins, a by-product of inflammation and also prostaglandins, the hormone-like compounds found through the entire body Thus Bromelain assists fighting the majority of inflammation occurring after having a sports injury or after surgery, or from minor sprains and tendonitis. Certain kinds of arthritis which involve inflammation also benefits from bromelain, particularly in combination with some other typical anti-inflammatory medications.

Do you take bromelain daily? If not, why not?

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The working principle of Curamin

Date: March 22, 2013 11:49 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The working principle of Curamin

Curamin is a natural pain reliever that functions well. It has four very powerful ingredients with synergistic properties which make it very efficient in pain relieving.

These ingredients are:

Curcumin longa: a compound that is used to prevent several inflammation pathways in the human body and is a powerful antioxidant.

Boswellia serrata: a substance which slows down the performance of inflammatory enzyme.

Nattokinase is a type of enzyme which assists the cardiovascular system and also helps other inclusions to go to other regions of the human body.

DLPA stops the disintegrating of enkephalins which relieves the body muscles from pain and boost mood.

The above named components works on particular cells which are sending pathways which consist of nerves that relay unwanted signals which are eventually amplified by the interconnected and overlapping pathways. During this process, curamin ingredients come together and blocks the way going to these signaling pathways which in the long run gets rid of the messages being sent. It's very good to put into consideration that it's not the same system used with conventional synthetic medications which include; aspirin, paracetamol, ibuprofen and diclofenac which are used to aim at one particular pathway and leave other subsidiary pathways unchecked.

Curamin works in very distinct ways which makes it to be reliable and effective. These ways are:

Curcumin is a system modulator which immunes and safeguard the body from oxidative stress. EuroPharma Curamin is a way in which the body provides temporary relief of pain and eventually improving the natural defense mechanism of the body. Curcumina is a component of Curamin which supports the natural anti-inflammatory response of the body.

Enzyme Nattokinase is a significant component of Curamin which aids in circulation of nutrients to get where they are required and helps in getting rid of waste from the body. It also balances fibrinogen levels in the body which is crucial since too much of it leads too pain in the muscles.

It is therefore advisable to use curamin since it has no side effects.

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What Is 2000fu In Nattokinse?

Date: December 29, 2012 11:48 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Is 2000fu In Nattokinse?

Nattokinase: History And Health Benefits

Nattokinase is a proteolytic enzyme that naturally occurs in natto. It is a traditional fermented soybean dish and a well-known staple food in Japan. Natto is fairly easy to make since it only requires water, straw and soybeans. The straw that has the bacterium called bacillus subtilis natto will be mixed with the freshly steamed soybean and water. After that, it will be set for fermentation. During fermentation, natto develops its mild taste and it has a very strong odor like that in the blue cheese.

In the year 1980, Dr. Hiroyuki Sumi was looking for a food that can effectively break up blood clots like those that can cause cardiac arrest and stroke. He discovered that natto can dissolve fibrin which is the type of protein that builds up in blood clots. In his laboratory experiment, he discovered that natto has the ability to completely dissolve fibrin clots after almost about 18 hours. Natto is low in cholesterol and it contains high quality protein and an excellent source of vitamin K, copper, iron, magnesium and manganese.

Nattokinase works similarly like blood-thinning agent coumadin. People who have had vascular injury or those people who are in risk of elevated fibrinogen level formation can benefit from the fibrin-digesting effects of nattokinase. It also reduces the thickening of the arteries and helps to heal damaged blood vessels.

What Does "FU" Mean in terms of Nattokinase?

Companies that manufacture nattokinase supplements express its activity in terms of "FU" or fibrin units. This is entirely different from the IU measurement since it only indicates nattokinase activity base on the degradation of fibrin. But as of today, IU is being officially adopted by the Japanese when measuring nattokinase. The FU method doesn't have exact measure of nattokinase activity and is suspected to be erroneous. Because of that, IU standard is being used to accurately measure nattokinase.

However, the FU measurement is still being widely used in labels. Most nattokinase supplements nowadays are in 100 mg capsule with 2,000-4,000 FU. As a precaution, it's best to consult a doctor first before taking nattokinase supplements for appropriate guidance and supervision with regards to its proper usage. Pregnant women including those people who have had stroke before or any other bleeding disorders must not take nattokinase supplements.

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Does Curamin work?

Date: December 22, 2012 11:00 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Does Curamin work?

The Big Question: Does Curamin work?

Well, this herbal supplement is a quick, natural and safe pain reliever, which has been proven to work. Moreover, the composition does not have any side effects on the body. It enhances the defense mechanism of the body against any inflammation.

Curcumin (Inflammation Management)

The main ingredient of Curamin, Curcumin enhances the anti-inflammatory components of the body and works as the immune system's modulator. This implies that whenever you consume Curamin, it renders long term effects on the body, thereby controlling oxidative stress.

Nattokinase (Circulation and Inflammation)

Curamin contains an enzyme referred to as Nattokinase, which helps the circulation of the body and thus nutrients reach all corners of the body. Therefore, whatever part of the body might be affected, you can experience results after a few minutes of consumption. Similarly, waste products are also removed from one's body via excretory system much more efficiently. Nattokinase balances the fibrinogen level, meaning the muscles are repaired quickly when they are injured as a result of heavy muscular strain. Curamin has

DLPA (Mood Enhancer)

DLPA amino acids which hinders the breakdown of enkephalins. Enkephalins are often associated with moods. Therefore, you'll never have irritating feeling while undergoing stress and pain anymore. You can carry out your daily activities or even have happy moments with your family during the pain and inflammation.

5-LOX (Inflammation Trigger)

Most inflammations are triggered by uncontrolled behavior of the inflammatory enzyme, known as 5-LOX. This formula helps turn off the 5-LOX enzyme.

Boswellia (Anti-inflammatory Herb)

Curamin contains Boswellia serreta extract, a beta-boswellic acid, which hinders this enzyme's activity. Inflammation can be triggered by several factors. To handle all these factors, Turmeric: Curcumin longa is included in the Curamin. Curcumin longa, extracted from turmeric, is a great antioxidant. Inflammation and pain are common in life and they usually draw you back from having a stress free life. This is where Curamin comes in handy by offering the much needed relief to get rid of pain from your daily life.

Curamin Has a money back guarantee if it does not work by the end of the bottle send it back for a refund.

We offer free shipping and a $5.00 coupon on each bottle of curamin purchased.

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All about curamin

Date: December 13, 2012 11:35 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: All about curamin

For those who never really hard about it, they should know that Curamin contains is up to ten times strong than the regular curcumin products. It's actually one of the best ways through which individuals will be able to balance their body's natural inflammation response and many recent and past studies support its ability. Through the removal of pro inflammatory compounds which are generally present in this plant, the impact of boswellia is very much enhanced.

DLPA was showed in many studies to actually be very helpful with maximizing the effects of enkephalins and endorphins, which are natural and very powerful pain relievers produced by the human body. Nattokinase is rounding up the formula and for those who don't have any idea what it is, they should know it's actually an enzyme. It directly affects muscle pain through its ability to have the fibrinogen levels in the body balanced and at the same time it will also ensure people have a healthy blood circulation in the body. Many people are already aware of the fact that if they take ibuprofen and also aspiring for long periods of time, they will experience serious stomach bleeding and at the same time, if they take Tylenol and ibuprofen, the toxicity in their kidneys and liver will increase very much.

However, with the more safer and also more effective alternative of Curamin, who would ever want to consider the aforementioned medicines?

Curamin, this is a natural pain killer anyone can take. Its combination of dl-phenylalanine, boswellia, cuminoids and Curcumin make it a really effective pain reliever. The way it works is that it will help with stopping the triggers that switch on pain pathways and at the same time it will also reduce the inflammation. More than ninety percent of people who have taken Curamin said that in just forty five minutes, they experienced great pain relief. At the same time, they also said there were no side effects to deal with, meaning their kidneys, stomach and intestines didn't suffer any damage. Curamin actually works in conjunction with the body's natural ability to stop inflammations which is the reason why individuals feel pain.

The president and founder of Europharma in the United States said that it is really a great and effective product which everyone who is dealing with inflammations should use. Because he trusts this product so much, millions of Americans have actually turned their attention to it and regard it now as one of the most efficient pain relievers on the market. In 2009 Curamin was awarded the prize for having the best formula so far, a formula which doesn't let people experience any side effects and at the same time, it makes their inflammations and pain go away really quickly. It seems that as time passes, Curamin is also getting better and more and more effective formulas appear. With that being said, everyone who will take Curamin in order relieve his pain or inflammation will feel great in less than an hour!

curamincoupon1201

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Can Serrapeptase Help Break Down Cholesterol?

Date: December 01, 2012 11:22 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Serrapeptase Help Break Down Cholesterol?

When we think of silk worm the first thing that comes to our mind is clothing and not disease treatment. The serrapeptase enzyme derived from the silk worm has been used by people around the world to treat various conditions as well as lower the levels of bad cholesterol. The few trials that have been conducted are mixed though it has a future in the reduction of cardiovascular disease. High levels of cholesterol should not be ignored as it is dangerous and serious. Choosing the natural ways will really pay.Formation of plaque in the arteries involves the deposit of fibrin, calcium, cellular waste products, cholesterol and fatty acid in the inner lining of the artery and would result to complete or partial blockage of the artery.

Reduce plaque buildup with silkworm enzymes

The serrapeptase helps in removing the cholesterol and the other deposits causing the plaque breaking down the plaque through its protein dissolving properties.Serrapeptase has been used to reduce the inflammation and is one of the ways to get cholesterol deposits in the arteries inner lining. It dissolves or digests the non-living tissue the serrapeptase is taken as a tablet that is enteric coated and it will not be dissolved by the stomach acids rather it will be absorbed in the bloodstream. There are health plans that are available that will optimize your plans to lower the cholesterol.

Medications do have side effects and one has to look for other ways to lower the LDL cholesterol and increase the levels of HDL cholesterol. This enzyme doesn't interfere with the synthesis of the cholesterol, but instead keeps a vital tissue form the wall of arteries and has anti-inflammatory properties. In its pure state the cholesterol is an antioxidant and it is necessary for the hormonal systems of the body. Medications blocking its biosynthesis cause liver damage and compromise the other soft tissues. Serrapeptase is the natural way to clear off this bad cholesterol

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What Are The Health Benefits Of Nattokinase?

Date: May 12, 2012 07:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Are The Health Benefits Of Nattokinase?

Nattokinase

Did you know that nattokinase was first found in traditional Japanese cuisine? And that it has been proven to be very helpful in fighting heart related complications among other health problems? Well, heart attacks and heart related complications are ranked among the top killer diseases in the country today. Around 700,000 people are believed to die as a result of strokes annually. Concern has been increasing over the ever falling heath condition of the population. Some of the major causes of heart related complications are:

Taking foods that have a very high content of fat and bad cholesterol

Taking food with high levels of salt

Inherited heart related complications

Among the three, the first two are the most common causes. But it is possible that the source of the problem is also the solution. Most health professionals are nowadays recommending the inclusion of nattokinase in the daily diet to combat heart disease.

So what exactly is nattokinase?

This is a very powerful enzyme that is extracted from fermented soy bean food products. It is believed to have the benefit of reducing clotting of blood in the vessels. It also promotes the creation of healthy fibrin. It is also known to provide relief for joint inflammation. If you consume huge amounts of food that is high in cholesterol, it forms a substance called plaque in your arteries. This is what causes clots, leading to heart attacks. Nattokinase works by breaking down the plaque and also dissolving any clots. Thus, it actively prevents heart attacks.

The health benefits associated with nattokinase

It is believed to actively improve the digestive system.

This is because it breaks down unwanted proteins in the gut, leaving your digestive system very healthy. It also breaks down unwanted toxins in the blood. Such toxins include cellular debris found in the blood. When the blood is cleansed, absorption and metabolism improve, and the result is a healthy person.

It helps normalize blood pressure.

High blood pressure is often caused by clogged arteries and veins. It can also be as a result of high levels of toxins in the blood. As said earlier, this enzyme breaks down the plaque that clogs arteries. As a result, blood flows more freely in the vessels and the pressure goes down. It also cleanses any toxins in the blood, normalizing the blood pressure. It has been proven to lower systolic blood pressure by up to 10.9%.

It aids the increased production of plasmin.

This is the body's natural mechanism of fighting clots. Studies have shown that nattokinase is four times more active in preventing clots than plasmin. Animals with clots are observed to heal four times faster when injected with the enzyme than when given plasmin.

It helps in the prevention of varicose veins, muscle spasms and pains.

Varicose veins are caused by weak or damaged valves in the blood vessels. Valves get destroyed when too much pressure is applied on them. This enzyme works by removing clots and thus lowering blood pressure. As a result, valves are not overworked to the point of getting destroyed.

If you are interested in staying healthy, then it is wise to have this enzyme in your diet. Nattokinase will help you fight heart related complications. As a result, you will enjoy a longer healthier life.

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Serrapeptidase: Natural NSAID

Date: March 27, 2012 03:26 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Serrapeptidase: Natural NSAID

Serrapeptase, also known as Serratia peptidase is a proteolytic (protein-splitting) bioactive enzyme found in the intestines of the silk worm. This silk-worm enzyme is widely used in Europe and Japan in clinical therapy for relieving pain and inflammation. When the silk worm leaves the cocoon, it regurgitates the serrapeptase in to create a hole in the cocoon for its escape. It was soon discovered that serrapeptase enzyme has a unique property to dissolve dead material consisting protein without even harming the living tissue. This property of dissolving dead tissue can be used in treating many health conditions.

How Serrapeptase work?

Protein is the main component of most of the fibrous materials in the body. Once these fibrous materials out-live their purpose or are over-grown, they start causing serious disease conditions involving fibrosis. Fibrosis is an abnormal thickening and scarring of connective tissue caused by infection, injury, surgery or lack of oxygen. Serrapeptase works as an anti-fibrotic and helps in relieving the conditions in connective tissue scarring and thickening has occurred.

Health Benefits of Serrapeptase:

This proteolytic enzyme is considered an alternative to NSAIDS (Non Steroidal Anti-Inflammatory Drugs) that are used to treat osteoarthritis, rheumatoid arthritis and other inflammatory conditions. Serrapeptase has been used to treat fibromyalgia, colitis, Inflammatory Bowel Diseases, varicose veins, ovarian cysts, ear and throat infections, enlarged prostate and postoperative inflammation. Studies have shown its effective results in prevention and removal of arterial plaque.

Serrapeptase in relieving Pain:

Pain and Inflammation Reduction:

Serrapeptase is a great anti-inflammatory and analgesic agent. It reduces the inflammation and gives relief from the pain. It works by blocking the release of pain inducing amines from the inflamed tissues. Due to its pain relieving and anti-inflammatory properties, serrapeptase is used in treatment as an alternative to NSAIDS. This enzyme gives relief from mild to moderate pain like headache and backaches. Hence it is used all the inflammatory conditions such as colitis, sinusitis, arthritis and many more.

Cardiovascular Health:

Serrapeptidase has an anti-fibrotic and fibrinolytic action that prevents and treats the accumulation of plaque in the arteries. Plaque is the accumulated deposits of cholesterol, fatty substances, cellular waste products, fibrin and calcium. Excessive plaque formation impairs the normal blood flow and cause partial or complete blockage, which also results in arteriosclerosis. Serrapeptidase helps to prevent build-up of plaque in the body. Due to its fibrinolytic action, it also helps in dissolving of proteins and breaking down atherosclerotic plaques. The dissolved deposits are eliminated from the body.

Hence, serrapeptidase prevents coronary artery diseases and improves cardiovascular health.

Relieving Sinusitis:

Due to its anti-inflammatory and mucus dissolving properties, Serrapeptidase is very beneficial for chronic sinusitis sufferers. Serrapeptidase helps in thinning and expelling the thickened mucus secretion present in nasal cavities of sinusitis sufferer.

Promoting Healing:

Serrapeptidase helps in reducing the recovery time in any injuries, wounds or surgery. It promotes healing in post-operative wounds by reducing the inflammation and pain.

Serrapeptidase is available in the form of supplements. If you are taking NSAIDS for any healthy condition, substitute it with serrapeptidase supplement

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8 Major Benefits of Nattokinase

Date: February 18, 2012 07:18 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: 8 Major Benefits of Nattokinase

Nattokinase

The need to live and eat healthy has grown other years. However, every time you hear of a new health supplement or food type, you are never sure of its exact impact on your wellness. But for nattokinase, you can be sure that is benefits to your health are true. Here is how your body benefits from the use of nattokinase.

Background Information of Nattokinase

Before you learn about its advantages , here is a little background on this supplement. Nattokinase or natto is a wholesome and nutritious Japanese food that is derived from soybeans. In its native country,it is taken with rice. To make natto, boiled soya beans are mixed and fermented with a bacterium referred to as Bacillus Natto. After the fermentation process, the enzyme nattokinase - the main active ingredient in the supplement- is produced.

Major Benefits

One of the best known effects of natto is that it reduces clotting in blood by dissolving fibrin. When fibrin escapes to blood, it binds platelets together resulting in a clot. In young people, production of plamin - an agent that reduces synthesis of fibrin - is at its maximum. However, as people get older and in some disease conditions, less plasmin is produced thus the risk of developing clots. Natto contains agents that work like plasmin and therefore is used in place of plasmin.

By countering the production of angiotensin converting hormone (ACE), natto lowers the pressure of blood. The hormone mentioned above reduces the elasticity of blood vessels; consequently, the vessels become narrower. Narrow vessel lead high blood pressure. In addition, by making the blood vessels soft and supple , it increases the supply of blood to all parts of the body.

Body cells need proteins to grow and function optimally. However, as people age, the ability of the body to utilize and absorb proteins is reduced. As a result, skin cells grow don't rejuvenate quickly. Natto contains high levels of proteins and vitamin K2 - a well documented anti-aging factor.

Nattokinse and cholesterol

Nattokinase reduces the bad cholesterol in the body by transporting it from the blood vessel to the liver where it's eliminated. Moreover, natto prevents osteoporosis by lowering the rate at which calcium is removed from the body. By taking nattokinase, the risk of heart diseases especially those that plaque blood vessels is reduced.

More Yet

Other Health Benefits of Nattokinase.Prevents loss of hair.Soothes the muscles and reduces pain joints.Lowers the risk of Alzheimer's disease.Prevents other diseases that are caused by clots in blood. What more! So far there are no serious health side effect are associated with the use of this product.In any case, the Japanese have been using this product for a long time.In fact, the generally low levels of heart diseases in its native society are associated to the use of nattokinase. However, lactating and pregnant women should only take this and other supplement after medical advice.In addition, if you are to undergo surgery, please be sure to consult your surgeon before use. Above all, you must read all the manufacturers instructions and recommendations before use.

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What Supplements Are Useful In Combating Blood Clots?

Date: October 04, 2011 03:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Supplements Are Useful In Combating Blood Clots?

Vitamins And Your Health

As we know for a fact, one of the properties of blood is its ability to coagulate in order to stop bleeding. This coagulated blood is commonly known as a clot. Blood clot is important to the body to prevent excessive bleeding and serves as a vital part in the process of inflammation and wound healing. However, if a clot occurs abnormally it can cause significant danger to the body. A blood clot can cause obstruction in the circulation and may result to life - threatening health conditions such as heart attacks, cerebrovascular accident or strokes and pulmonary embolism. It can also cause poor tissue oxygenation and perfusion which can damage the affected cells and might cause disability or inability to function of certain organs or body part.

There are many traditional modalities in preventing and treating abnormal blood clot formation. One of the most commonly used is the medication called Aspirin in low – dosage. This conventional drug is popularly prescribed by doctors to decrease the clotting property of the blood. However, in emergency cases, a surgical procedure may be deemed important to remove the blood clot which significantly interrupts proper blood circulation.

Aside from medications, there are many supplements that have the capacity to decrease the risk of abnormal blood clotting. These include supplements high in:

1. FISH OILS. Fish oils are rich in omega-3 fatty acid which has the capacity to thin the blood. Therefore, if the blood is not viscous, the pressure inside the blood vessel is lesser as well. A high blood pressure can cause damage to the walls of the blood vessels, thus activating blood clot formation. Also, a non – viscous blood can also better circulate into smaller blood vessels than that of a viscous blood, therefore, enhancing tissue oxygenation. Clinical studies also revealed that omega – 3 fatty acids can effectively decrease Thromboxane A which is one of the clotting factors found among platelets.

2. CHAMOMILE. This herb has an anti – platelet property. It has a mild to moderate effect in regulating clot formation.

3. GINGER. Ginger has many health benefits. One of its promising benefits is its mild anti – platelet property and its ability to dissolve fibrin. This herb is widely used as a supplement to enhance blood circulation all over the body.

4. CATECHIN AND QUERCETIN. These chemical compounds are classified as antioxidants. They can effectively reduce the adhesion property of platelets.

5. CURCUMIN. This chemical comes from the spice called turmeric. This is considered to be an anti – thrombotic, as well as a potent anti – inflammatory agent.

6. DEHYDROEPIANDROSTERONE (DHEA). This substance is primarily an anti – aging agent. However, studies reveal that it can significantly reduce the process of inflammation by preventing the substance that can generate inflammation within the veins, arteries and capillaries called Cytokines. With decreased production of cytokines, it will result to lesser coagulation and clumping of platelets and reduced movement of bad cholesterol or Low Density Lipoprotein (LDL) into the walls of the blood vessels, thus decreasing the chance of clot formation and atherosclerosis.

7. VITAMINS C AND E. These vitamins are important for preventing abnormal collagen – induced platelet activation by inhibiting the production of hydrogen peroxide. Vitamins C and E are also important in many enzymatic actions that regulate blood cholesterol levels.

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How Does Serrapeptidase Support A Healthy Immune System, Regulate Inflammation, And More?

Date: September 01, 2011 02:25 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does Serrapeptidase Support A Healthy Immune System, Regulate Inflammation, And More?

What Does Serrapeptidase Do In The Body?

Serrapeptidase is an enzyme which is protein - digesting by nature. It is considered to be one of the types of proteolytic enzymes which consist of the chemical substance protease. This chemical is derived from a non - genetically engineered fungus of the family of Aspergillus. Serrapeptidase is a dietary supplement which may be isolated from Serrapeptidase oryzae and Serrapeptidase melleus. Studies have claimed that this dietary supplement is effective as an anti - inflammatory, respiratory aid, cardiovascular or immune support. Other names of Serrapeptidase include serration - peptidase and serrapeptase.

During the early 1990’s, Serrapeptidase was isolated from the microorganism Serratia marcescens which is a known human pathogen found in the digestive tract of the Japanese silkworm. Many studies have been conducted to uncover the medicinal purposes of this bacterial enzyme. In fact, it has been widely used clinically in specific areas of Asia and Europe primarily as an inflammation relief agent.

These are some of the uses of the enzyme Serrapeptidase:

1. ANTI – THROMBIC AND fibrinOLYTIC. Serrapeptidase can significantly prevent the build – up of blood clots. These clots must not be accumulated to prevent thromboembolism which can cause life threatening health conditions such as heart attack and stroke. Aside from its ability to prevent clot formation, Serrapeptidase also has a good fibrinolytic ability. It can lyse or dissolve already – formed blood clots.

2. PH REGULATOR. This proteolytic enzyme is considered to be an alkaline metalloprotease enzyme. It can selectively act on specific biological systems and prevent the activation of immunoglobulin G and immunoglobulin A. These body chemicals are immune system factors which helps the body prevent from infections and illnesses.

3. GOOD PROTEIN DIGESTER. Clinical studies have revealed that Serrapeptidase has a very good ability to digest protein molecules and its substrates. This is the reason behind why Serrapeptidase can effectively dissolve protein – based tissues such as fibrins, blood clots, cysts and certain inflammations. The advantage of this enzyme is that it can dissolve unnecessary tissues without harming the normal living tissues.

4. PROFOUND ANTI – INFLAMMATIORY AGENT. Serrapeptidase can effectively prevent and reduce inflammation, thus reducing swelling and pain sensation. The mechanism of action is said to be that Serrapeptidase blocks the synthesis of pain – inducing amines. Another mechanism is that it can effectively inactivate pro – inflammatory chemicals known as cytokines. In fact, this chemical is one of the components of analgesic drugs in Europe. The positive effect of this enzyme is that it does not have any digestive side effects.

5. RESPIRATORY AID. This enzyme is also helpful in improving the health of the respiratory system. It effectively alters the elasticity and viscosity of the dense mucus in people with respiratory problem such as sinusitis, bronchitis, asthma, and pulmonary diseases. People who are taking this enzyme supplement have shown improved liquefaction and expectoration of the mucus, thus Serrapeptidase is considered to be an effective mucolytic agent widely used all over the world.

Serrapeptidase is generally safe. Clinical studies have revealed that the sources of this enzyme are non – pathogenic except of one strain known as Serratia marcesens. This strain is pathogenic to human body. It may cause hypersensitivity or any untoward signs and symptoms. Therefore, it is best to consult a doctor before starting such supplementation.

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How Does Nattokinase Help Improve Cardiovascular Health

Date: April 29, 2011 04:01 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: How Does Nattokinase Help Improve Cardiovascular Health

Nattokinase And Your Health

Nattokinase is an organic compound that occurs naturally in the Japanese food natto, or fermented soybeans. It is an enzyme that acts on fibrous proteins responsible for blood clothing, and as such has been commercially touted to work like thrombolytic medications to a certain degree. Its synthesis involves fermentation that results from adding the bacterium Bacillus subtilis to boiled soybeans.

Natto is a traditional dish in Japan. It has enjoyed long-standing popularity among the Japanese people since feudal times largely owing to its reinvigorating effects on the blood. In recent years, laboratory studies point to the presence of chemical compounds in fermented soybeans. The enzyme nattokinase appears to be the active ingredient, improving fibrinolytic activities in animal subjects.

Breaks Down Blood Proteins

Proteases are enzymes capable of reducing proteins into smaller peptide chains in the digestive system or anywhere in the body. A special kind of protease called plasmin is found in the blood. It is the primary enzyme that facilitates the catabolism of fibrin clot, or coagulated blood protein. fibrinolysis is the process initiated by the enzyme plasmin to dissolve compacted red blood cells.

Thrombolytic drugs work on the principle of raising the levels of plasmin in the blood. Streptokinase is one of these drugs. It is commonly administered in the treatment of myocardial infarction, or heart attack to avoid complications. Natto has been compared to streptokinase, and oral intake of nattokinase has been observed to stimulate productions of plasmin.

Prevents Blood Coagulation

Nattokinase has been extensively studied in Japan, though well designed large-scale randomized clinical trials are still needed to establish its purported benefits to human health. There is buzz around nattokinase in the pharmaceutical industry especially as early studies suggested that it may ameliorate complications of cardiovascular diseases, notably in the removal of platelet-fibrin emboli.

There have been numerous citations on the blood-thinning capacity of nattokinase. This enzyme is also believed to have an inhibitory effect on platelet aggregation. Thrombocytes, or platelets, are necessary for containing excessive bleeding. However, aggregation of platelets may result in thrombosis in patients with history of atherosclerosis and other disorders of the blood vessels. Nattokinase is a blood thinner that affects both platelets and fibrins.

Improves Cardiovascular Health

In addition to its thrombolytic and anticoagulant properties, nattokinase has been reported to promote normal flow of blood. Natto has been linked to the alleviation of high blood pressure and has seen desirable outcomes in hypertensive patients. Recent studies have shown that nattokinase is responsible for producing antihypertensive and vasodilator effects when natto enters the systemic circulation. It is postulated that nattokinase inhibits angiotensin-induced vasoconstriction.

The Japanese have always believed that natto is good for the blood. Nattokinase remains under scrutiny, but clinical trials are well underway. A growing body of literature devoted on promoting its alleged health benefits draws so much on decades-long anecdotal evidence.

If you want to improve cardiovascular health, give Nattokinase a try!

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Bromelain Supplements why?

Date: November 06, 2010 10:32 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Bromelain Supplements why?

pineapple bromelain Bromelain enzyme may not be as familiar as other digestive supplements to most people but this helpful catalyst offers a wide range of benefits not only to the digestive system but also to other systems of the body.

Bromelain Enzyme Supplement

Bromelain enzyme is a proteolytic digestive catalyst that contains sulfur. From the word “proteolytic”, this substance aids in the digestion of proteins especially when taken with meals. On the other hand, when taken without meals, it is deemed to act as an anti-inflammatory supplement. Ananas comosus or the pineapple plant is the best source of this beneficial enzyme. However, fresh pineapple extract does not contain doses high enough to have a medicinal effect. Hence, a preparation to meet the body’s demand is produced. Bromelain supplements now come in the form of tablets and topical creams. They are now widely available and affordable to counterweigh the several uses it offers.

In the Digestive System, bromelain enzyme does not only help in digesting proteins but may also relieve gastric upset and heartburn especially when used together with other digestive enzymes like amylase, a catalyst responsbile for carbohydrate digestion, and lipase which is for the digestion of fats. Diarrhea conditions associated with deficiency in the proteolytic enzymes can also be alleviated with the use of this supplement.

In the Immune System, bromelain has been widely considered as an effective relief for pain and swelling caused by both injury and certain infections. Studies frequently show the bromelain’s ability in facilitating the body to restore health more quickly. The mechanism is said to be a reduction of fibrin and leukotriene accumulation, thus regulating the inflammation process. Researchers have demonstrated evidences that a daily intake of 1,200 to 1,800 mg of bromelain may help alleviate painful inflammation just like in rheumatoid arthritis.

In the Cardiovascular System, bromelain supplement is theorized to play a role in the prevention of heart disease caused by atherosclerosis or thickening of the arterial wall due to plaque deposits. It slows down the clumping of platelets thus preventing a possible heart attack. digestive process bromelain

Bromelain May Also Relieve Pain

Lastly, bromelain may also relieve pain associated premenstrual syndrome and menstraul cramps. Studies reveal that they act as prostaglandin inhibitors. However, bromelain can also increase the bleeding during menstruation.

Bromelain supplement has no Recommended Dietary Allowance but doses of up to 1 gram taken 3 times a day showed no toxic effects. Experts also advise to take bromelain on an empty stomach supplemented with magnesium to increase the bromelain’s effects.

Just like any other drug or food supplement, bromelain also has side effects, nonlife-threatening to be exact. It may have drug interactions such as increasing the absorption of some medications like antibiotics, chemotherapeutic drugs and specific antihypertensive agents. In addition, it may also bolster the effects of blood thinners such as warfarin (Coumadin), anti-inflammatory drugs and antiplatelet agents such as clopidogrel (Plavix). Since bromelain supplement can cause certain drug interactions, it is important to take this enzyme cautiously or under the supervision of a qualified health care provider.

To find quality bromelain supplements, look to your local or internet vitamin store.
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Thrombophlebitis

Date: April 15, 2009 01:20 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Thrombophlebitis

Thrombophlebitis is when inflammation occurs in the veins due to the formation of a blood clot in that vein. This problem usually occurs in the extremities, especially the legs. Thrombophlebitis can be considered superficial if it affects the subsutaneous vein, which is one of the veins near the skin’s surface.

In superficial thrombophlebitis, the affected vein can be felt and may be seen as a reddish line under the skin. Additionally, swelling, pain, and tenderness to touch can occur. If widespread vein involvement is included, the lymphatic vessels may become inflamed. Superficial thrombophlebitis is a relatively common disorder that can be brought about by trauma infection, standing for long periods of time, lack of exercise, and intravenous drug use. The risk of superficial thrombophlebitis can be increased by pregnancy, varicose veins, obesity, and smoking. Thrombophlebitis can also be associated with environmental sensitivities to allergies. This condition is usually diagnosed according to physical findings and a medical history that indicates an increased risk.

Deep thrombophlebitis (DVT) affects the intramuscular veins farther below the skin’s surface. DVT is a much more serious condition than superficial thrombophlebitis because the veins affected are larger and located deep within the musculature of the leg. These veins are responsible for the transport of 90 percent of the blood that flows back to the heart from the legs. Symptoms of DVT may include pain, warmth, swelling, and bluish discoloration of the skin of the affected limb. These symptoms are often accompanied by fever and chills. The pain is typically felt as a deep soreness that is worse when standing or walking and gets better with rest, especially with elevation of the leg. The veins directly under the skin may become dilated and more visible. Inflammation situated in a vein in the pelvis is referred to as pelvic vein thrombophlebitis.

The reason or reasons for the formation of the clots in the veins are often unknown. However, in most cases, clots are probably the result of a minor injury to the inside lining of a blood vessel. If the vessel lining receives a microscopic tear, clotting is initiated. Platelets clump together to protect the injured area, and a series of biochemical events is initiated that results in the transformation of fibrinogen, a circulating blood protein, into strands of insoluble fibrin, which are deposited to form a net that traps blood cells, plasma, and yet more platelets. This results in a blood clot. Other possible causes of the formation of DVT include abnormal clotting tendencies; poor circulation; certain types of cancer; and Behcet’s syndrome, which is a condition that affects small blood vessels that predispose an individual to the formation of clots. The following factors increase the risk of DVT: recent childbirth, surgery, trauma, the use of birth control pills; and prolonged bed rest.

The following nutrients are recommended for the prevention and treatment of thrombophlebitis: acetyl-l-carnitine, coenzyme Q10, flaxseed oil, garlic, l-cysteine, lecithin granules, l-histidine, magnesium, MSM, Pycnogenol, vitamin C with bioflavonoids, vitamin E, zinc, and vitamin B complex. Additionally, the following herbs may be beneficial: alfalfa, pau d’arco, red raspberry, rosemary, yarrow, butcher’s broom, cayenne, ginger, plantain, witch hazel, skullcap, valerian root, ginkgo biloba, goldenseal, hawthorn, and olive leaf extract.

Natural vitamins are a great way to help prevent conditions such as these. If you suspect that you have thrombophlebitis, consult your doctor before trying to take the problem into your own hands. Natural vitamins such as the ones listed above can be found at your local or internet health food store.

*Statements contained herein have not been evaluated by the Food and Drug Administration. Natural vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.

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Bromelain Enzymes

Date: May 01, 2008 02:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Bromelain Enzymes

Bromelain consists of two enzymes that digest proteins, otherwise known as proteases or proteolytic enzymes. These enzymes are obtained from different parts of the plant, one from the stem and the other from the fruit. It also includes protease inhibitors, acid phosphatase, peroxidase and calcium.

First used as a supplement in 1959, bromelain is particularly popular in Germany, where a lot of the recent research has been carried out. Because the stem enzyme is in the greatest amount, eating pineapple will not give a great deal of bromelain, and you will have to take the supplement which is extracted from the stem in order to get the greatest benefits.

Bromelain has several therapeutic effects on the body, and is a good aid to digestion. The enzyme can boost the digestive processes and so reduce the incidence of problems such as heartburn, acid reflux and any other condition caused by the incomplete digestion of foods. It does this by breaking down proteins so they are more easily digested.

In fact its potency is sometimes measured in GDUs (Gelatin Digesting Units), gelatin being a common protein that is easily used for the measurement of bromelain activity. It is also measured in MCU (Milk Clotting Units), since bromelain can also be used to clot milk, and a standardized dose should contain 2 MCU per milligram. The dosage to use depends a great deal on the condition being treated, but a good general average for digestive problems is 500 mg three times daily.

Bromelain works best at an optimum pH of 4.5 – 5.5 and can therefore help to balance the pH in its environment. It is extremely important to the immune system that the pH of the body is balanced and controlled to within certain limits, and bromelain can help to achieve that. In helping to reduce the excessive acidity caused by poor digestion, a balanced pH of the stomach is also maintained, helping to reduce the feeling of nausea, common with some digestive defects. The overall result of bromelain supplement is to help to maintain a better digestive system and ease the discomfort of many people for whom a meal is frequently not the pleasure it should be.

Bromelain is also an anti-inflammatory, and used for temporary relief of the inflammation caused by surgical procedures, arthritis and various injuries and forms of disease It is commonly used for the treatment of sports injuries and also immediately after surgery to reduce the risk of inflammation. It appears to have an inhibiting effect of the production of pro-inflammatory metabolites in the body, although the mechanism by which it works is not yet fully understood.

In fact many of the therapeutic benefits of bromelain have been show to be only partially due to its proteolytic activity, and it is now believed that there are also as yet unidentified non-protein factors present in bromelain that contribute to these forms of health benefit. The biochemistry of bromelain has yet to be fully characterized.

Notwithstanding that, the substance has been recommended for the treatment of a wide range of connected conditions, such as gout, arthritis, hemorrhoids, ulcerative colitis, autoimmune disorders, hay fever and sinusitis. It is particularly useful where there is pain, where tissues have become swollen and when tissue repair is needed. It appears to inhibit pain-inducing prostaglandins and is also believed in some way to induce the biochemical production of other prostaglandins that have an anti-inflammatory effect.

All of this knowledge has come as a result of studies carried out on the biochemical activity of bromelain, but have not yet been proved and is indicative of the lack of biochemical knowledge on this substance and the chemicals it contains. What have been demonstrated, however, are its effects on platelets and blood clots in arteries.

It appears to do this by the inhibition of the formation of high levels of fibrinogen from which clots are made, and also inhibits the aggregation of blood platelets and their ability to stick to the endothelial cells of blood vessels, particularly the arteries. The fibrin that is produced from fibrinogen not only promotes blood clotting but is also associated wit the retention of fluid. It is a protein, and the proteolytic effect of bromelain also breaks this down.

Bromelain therefore works in a number ways to reduce fluid retention, prevent blood clotting and inhibit the aggregation of blood platelets on artery walls. The measurable effect of this is the thinning of the blood that such activity promotes. It is logical that if fibrin contributes to the viscosity of blood, then its destruction will result in thinner blood, and hence lower blood pressure.

It is also used in the treatment of burns, where it helps to remove the dead skin that can delay recovery after third degree burns. It also appears to promote the absorption of many antibiotics, which again helps in recovery.

Bromelain is relatively safe to use with few side effects, although, curiously, among the side effects are some conditions it is also used to treat. Among these are nausea and allergic reactions, along with diarrhea and excessive menstrual flow. One of its successes has been in the control of menstrual pain.

Bromelain has been proposed for cancer therapy, its potential use being recommended due to its effect of the adhesion of cells, its regulation of the immune function and its effect on the immunosuppressive cytokine TGF-beta that is involved in several types of cancer and their metastasis (spread to other parts of the body). However, a lot more work is needed on this for definite conclusions to be drawn.

On a more practical note, the effect of bromelain on proteins is put to use as a steak tenderizer. If the product is sprinkled in powdered form onto meat, and then forked into the tissue, the enzymes will break down the protein of the meat and make it tender when cooked. However, don’t overdo it or you will end up eating a meaty mush more akin to a soft meatloaf than a good steak!

All in all, bromelain is a useful supplement for many medical conditions, and does to food in your stomach what it does to steak on the plate. It is generally used in supplement form because the active enzyme is not in a high enough concentration in the fruit itself, but in the stem from which it is extracted after the fruit has been harvested. It is also easier to standardize a supplement than a fruit.

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Looking For A Calcium But Not Sure Which Is Best For You?

Date: November 02, 2007 12:23 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Looking For A Calcium But Not Sure Which Is Best For You?

Calcium is essential to good health, but if you are looking for calcium it can be confusing to decide in which form you take it. There are so many available and every one claims to be good for you, so why the difference? Why not just sell the best and let us all know what it is? Well, this same argument could be applied to all supplements that are sold in different forms, and also to many foodstuffs.

The supplement best for you might not be the best for the next person due to dietary requirements each persons diet is different, so it is better to learn about what is available then make your choice based upon knowledge rather than ignorance. It is not only the source of the calcium you have to bother about, but also the other vitamins that have be present to make sure that that the calcium is absorbed by the body in the way that you want it to be.

To understand that then you need to learn why the body needs calcium, other than just the bones and teeth that everybody knows about. After all, why else do we need calcium? It is only contained in bones and teeth – right? Wrong!

Although 99% of calcium is contained in your bones and teeth, 1% is contained in the blood, muscles and central nervous system. With out that 1% we would all die. Without teeth we would not. Calcium is essential for blood clotting and for the proper function of our muscles, brain and central nervous system. Calcium combines with phosphorus to create healthy bones and teeth, and is essential early in life to build up a strong skeleton. Note that phosphorus is also necessary so we also need an adequate supply of that mineral.

Calcium is essential to allow muscles to properly contract. Without that ability, muscles could not work, and a deficiency of calcium causes muscle cramps and spasms. The movement of the smooth muscles is regulated by a protein that is bound to calcium. This is just one of the uses of the calcium in the body that most people are unaware of.

Calcium also takes part in the binding process of the blood platelets during the coagulation of blood. Although most people are aware of the need for vitamin K and fibrin, in fact calcium is also essential in its interaction with the platelets in the coagulation cascade that eventually results in a blood clot that stops bleeding. Basically, without calcium, the blood could not form a clot. In addition to its effect on blood clotting, calcium also plays an essential part in the movement of ions through the membranes of nerve cells, and without it intercellular communication could not occur. Our nerve impulses would not occur and the body again would not be in a working condition.

However, the body has a way of modulating the calcium level in the blood past a minimum level needed for effective nerve cell communication, and below a certain level it can even use the calcium in the bones to divert to the more needy areas of the body. It is therefore not possible for the body to fail through a lack of calcium. The skeleton would disintegrate first. Nevertheless, nobody wants a disintegrating skeleton since that would be counterproductive to effective movement of the body, so a good source of calcium is essential for overall bodily health, not just that of the teeth and the bones.

There are many sources of calcium, but some are more suitable for absorption by the body than others. Chalk, or calcium carbonate, is an excellent source of calcium, but will fail to promote bone growth if your diet does not contain sufficient potassium, vitamin D, magnesium and strontium needed to make it work to build healthy bones. It is the most common on the shelves, and likely the cheapest, but not necessarily the best source. It is basically chalk or limestone, and only 10% of the supplement will actually become available for your body to use.

The bioavailability of a calcium supplement is a figure that indicates how much of the calcium is actually absorbed by the body during digestion. It is important that the supplement is digested and absorbed properly or the calcium will not be available for use. This availability is called the ‘bioavailability’. Calcium citrate has a bioavailabilty of 50%, but the size of the citrate part of the molecule is so large that only 10.5% of the molecule is available to the body as calcium. Not much more than the carbonate.

Calcium aspartate is highly soluble and produced by reacting calcium with aspartic acid to form the soluble salt. It is much easier to assimilate and be absorbed by the body than any of the forms above. The amino acid, aspartic acid, delivers the calcium exactly to where it is needed, where it is absorbed and used. Although a bioavailability figure is not available, it is not the amount of calcium that is significant here but the fact that it comes with its own transportation system and is immediately available where needed.

If you want to calculate the availability for yourself, find the molecular weight of the particular calcium product, and then the weight of the calcium contained within it. For example, in calcium carbonate, CaCO3, the molecular weight is 100 (40 + 12 + 3x16) and the atomic weigh of calcium is 40, so the amount of calcium present in 1000g calcium carbonate is 40% or 400g. Only 25% of calcium carbonate is absorbed, so only 10%, or 100g, of calcium is available for each 1000g supplement.

Calcium citrate on the hand (Ca3(C6H5O7)2.4H2O) has a molecular weight of 570, so the amount of calcium present is 3*40*100/570 = 21%. Since the bioavailability of calcium citrate is 50%, the amount of calcium available is only 10.5%, or 105g in 1000g citrate. You can carry out the same calculation on all the molecules if you know how much is absorbed by the body.

The bioavailability is calcium aspartate is 85%. Its molecular formula is [C4H6NO2]2Ca, and molecular weight 304. The calcium availability is therefore 40*100/304 = 13.16%. If 85% is absorbed, then 1000g provides 80% of 13.16 x 10 = 115.6g. The aspartate therefore wins it.

Amino acid chelates can also be used as a source of calcium, and its bioavailability is improved tremendously by including vitamin D and magnesium in the supplement. The bioavailability of these calcium chelates are not quoted, but is claimed to be high. Whether or not it is as high as the aspartame is debatable, though it is claimed to be.

Calcium is a very important mineral for human health, and there are several different supplements that can be used. The bioavailability of the calcium is different in each supplement, though the organic forms, calcium aspartate and amino acid calcium chelates appear to be the highest. When looking for a calcium supplement look for one with additional minerals added as mentioned above to help improve absorption and usability by the body.

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Serrapeptase a modern marvel in cardiac research!

Date: April 15, 2006 08:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Serrapeptase a modern marvel in cardiac research!

When a silkworm is breaking through its cocoon it much to weak to muscle its way through with out help. The Silkworm has a special bacteria call serratia living within its self and this bacteria produces Serrapeptase which burns a hole out of the cocoon. The Serrapeptase enzyme breads down or dissolves dead tissue like silk.

Dr. Hans Nieper (1928-1998) used Serrapeptase as an arterial blockage treatment for patients in Germany.

Recent research has discovered that the Serrapeptase enzyme can break down fibrinoid layers in the arteries and possibly reverse blockage and narrowing of the arteries. Unlike most enzymes, Serrapeptase affects only non-living tissue and does not effect tissues that have live cells. Given time Serrapeptase could help restore blood flow and oxygen to vital organs and the brain.

Serrapeptase is also a natural COX-2 inhibitor, a natural pain killer, parts of Asia and Europe have been using Serrapeptase instead of the traditional steroidal anti-inflammatory drugs prescribed now a days. As time goes on we will learn more and more about this enzyme and its capabilities.

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Rutozym - Systemic Enzyme Supplement with Nattokinase

Date: February 22, 2006 05:08 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Rutozym - Systemic Enzyme Supplement with Nattokinase

Wobenzyme / Naturally Vitamins

Choose all-vegetarian Rutozym for smoother blood flow, stronger blood vessel walls, and a pacified inflammatory response.

Take Control of Your Heart Health

Heart disease claims an American life every 34 seconds, making heart disease the leading cause of death in the United States. Not only men, but also one out of every two women are affected by heart disease and stroke.

According to the American Heart Association, misperceptions about the risks of cardiovascular disease for women still exist, even though 50 percent of people with heart disease today are women, and more women than men die of stroke. After menopause, women are even more likely to have heart attacks than men.

Because of today’s standard of American fast-food diets and poor lifestyle habits, many people have high cholesterol and hypertension and suffer from circulatory disorders. People with excessive body fat are more likely to develop heart disease and stroke, even if they have no other risk factors. Obesity increases the strain on the heart, which contributes to coronary heart disease and can also make diabetes more likely to develop.

People in many other countries have somehow managed to maintain healthier hearts naturally. One reason may be the enzymes in their diet.

Nattokinase and Cardiovascular Health Experts credit much of Japan’s reputation for the lowest heart disease rate to nattokinase, an enzyme in the fermented soy-based cheese called natto. Although a Japanese staple for over 2000 years, the sticky, odorous cheese is, needless to say, an acquired taste. Fortunately the advantage is in the enzyme, now available in Rutozym.

Hiroyuki Sumi, MD, a researcher of the Japan Ministry of Education, discovered the enzyme and its remarkable benefits while searching for a natural way to break down excess fibrin in the blood, a major cause of heart disease, stroke, senility and even sudden death. Pleased with how successfully it dissolved fibrin and improved blood flow, Sumi (affectionately known as “Dr. Natto”) gave nattokinase its name.

Rutozym

In the 1980s when the story of systemic enzyme therapy was well underway, scientists invited Dr. Karl Ransberger, founder of the enzyme formula Wobenzym, to Japan to present his discoveries in enzyme research. The country’s low rate of heart attacks and its dietary link to natto intrigued Dr. Ransberger. Eager to investigate its potential use in alternative healthcare, he carried several pounds of natto home to Europe. After years of testing, his research confirmed that nattokinase did, in fact, improve blood flow by removing cross-linked fibrin from the blood stream.

Based on his nearly five decades of experience with the proteolytic Natural Support for Cardiovascular Health (protein-splitting) enzymes in Wobenzym, Dr. Ransberger knew that an enzyme mixture would prove even more effective than a single enzyme formula. So, to the nattokinase he added two of the enzymes in Wobenzym known to normalize inflammation. Then he increased its total effect with a proprietary flavonoid complex. As a result, the formula not only improved blood flow, it strengthened the integrity of blood vessels and helped manage the body’s systemic inflammatory response, promoting better overall health. Dr. Ransberger teamed up with Naturally Vitamins to further develop, test and perfect the Rutozym formula.

Today, Dr. Ransberger’s legacy lives on through Naturally Vitamins’ continuing research on systemic enzyme therapies. Most recently, Naturally began a 2003 clinical trial in Chicago to evaluate the benefits of Rutozym in heart patients. In cooperation with the leading manufacturer of Nattokinase in Japan, the trial will examine the effects of Rutozym on blood viscosity (thickness) and blood pressure. On completion, the results will be published in a peer-reviewed journal.

How Rutozym Works

Rutozym works by reinforcing your body’s own enzymes. As the building blocks of life, enzymes make every chemical action in the body possible. Though you are born with thousands of enzymes, as time goes by your supply diminishes. Scientific research shows that replenishing your natural supply with systemic enzymes can support your body’s immune functions and healing processes.

Rutozym is a plant-based systemic enzyme formula containing nattokinase. But it also contains other proteolytic enzymes and ingredients carefully blended to improve heart health and enhance your body’s innate ability to heal. Rutozym contains the proteolytic enzymes bromelain (from pineapple) and papain (from papaya) known to effectively rebalance the body’s inflammatory response. Rutozym also contains rutin to strengthen capillaries and other connective tissue, and white willow bark, which is often called “nature's aspirin.”

While doctors often recommend an aspirin a day to help prevent heart disease and stroke, the daily use of Rutozym has no gastrointestinal side effects. With new research, the scope of Rutozym’s benefits continues to increase. Supplement Facts

Serving Size: 2 Tablets
Servings Per Container: 60 amnt/serving %daily
Nattokinase (20,000 FU/gm) 25mg *
Bromelain (2,450 GDU/gm) 90mg *
Papain N.F. (2,400 USP Units/mgl) 100mg *
Rutin bioflavonoid Complex (rutosides & rutinosides) 120mg *
White willow bark extract (15% solicin/7% plyphenols) 100mg *

* Daily value not established.

Other Ingredients: Plant Fiber, Povidone, Modified Cellulose Gum, Colloidal Silica, Titanium Dioxide Mineral, Vegetable Stearic Acid and pH-Resistant Enteric Coat.

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New Frontiers in Enzyme Supplementation

Date: February 16, 2006 04:17 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: New Frontiers in Enzyme Supplementation

New Frontiers in Enzyme Supplementation

By Nick Rana, CN, NOW Quality Assurance

Serrazimes® is a proteolytic (protein digesting) enzyme system containing protease that is derived from edible non-genetically engineered fungi (Aspergillus oryzae and Aspergillus melleus), that is designed as an alternative for Serrapeptidase (also known as serratio-peptidase and serrapeptase) in dietary supplements used for cardiovascular, anti-inflammatory, respiratory, or immune support.

Serrapeptidase was initially isolated from Serratia marcescens, a potentially pathogenic bacteria found in the gut of the Japanese silkworm. Recognized as a pharmacological agent, Serrapeptidase has wide clinical use in Asia and Europe for the management of assorted inflammatory processes (Rothschild, 1991). In recent years, recognition of the efficacy of the Japanese product has lead to growing interest in the US dietary supplement market.

The product’s efficacy and availability over the internet has fueled its popularity in the US dietary supplement industry, where it is used for anti-inflammatory support, cardiovascular support, respiratory support, and as an adjunct to antibiotic therapy. Recognizing the potential for a "Serrapeptidase-type” enzyme in the U.S. dietary supplement market, the National Enzyme Company developed a protease system that has the same in vitro (lab test) activity as Serrapeptidase, but that is from organisms that have a long history of safe use in dietary supplements. Serrazimes® is the product resulting from this search.

Since the 1960’s, plant and microbial protease enzymes have been studied for their role in the management of inflammation and inflammatory processes. In both animal and human trials, proteolytic enzymes, from a variety of sources, have repeatedly been shown to significantly reduce inflammation resulting from sickness or injury (Ryan, 1967)(Smyth et al, 1967)(Shaw, 1969)(Kumakura et al, 1988)(Lomax, 1999). The earlier research on the anti-inflammatory actions of proteases pointed entirely to their antithrombic and fibrinolytic aspects to explain this phenomenon. However, studies by Parmely (Infect and Immun Sept 1990) and others indicate that, in addition to degrading fibrin, microbial proteases may actually inactivate pro-inflammatory cytokines and to interrupt inflammatory responses.

Persons taking blood thinning or antibiotic medications and those with serious health disorders should consult their medical practitioner prior to taking Serrazimes®. As is the case with most supplements, please consult your doctor about the use of Serrazimes® during pregnancy and lactation.

The Product Development Team at NOW Foods is constantly researching new products like Serrazimes® to provide our customers with the tools that empower them to live healthier lives. Look also for our new unique digestive enzyme formulations from plant sources - backed by laboratory studies - to be introduced in March of 2006.

TECHNICAL NOTES:

Serrapeptidase is a selective alkaline metalloprotease enzyme, meaning that it works to activate specific biological systems of mammals and directly degrades or inhibits IgG and IgA immune factors as well as the regulatory proteins á-2-macroglobulin, á-2-antiplasmin, and antithrombin III (Molla et al, 1989)(Maeda and Molla, 1989).

While originally isolated from Serratia marcescens, a bacteria found in the gut of the Japanese silk worm, Serrapeptidase activity is also found in fermentation extracts of Serratia E-15, Aspergillus oryzae, and Aspergillus melleus. (Salamone and Wodzinski, 1997).

The Serrapeptidase activity of this high potency proteolytic (protein digesting) enzyme is determined using a spectrophotometric assay testing procedure that measures the enzyme’s ability to hydrolyze (digest) a standard casein protein substrate. Laboratory analyses have established that Serrazimes® has a 1:1 enzymatic equivalent of Serrapeptidase activity guaranteed to provide 600,000 specialized proteolytic Units per gram, or 20,000 units per capsule.

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Policosanol and Nattokinase together!

Date: December 31, 2005 09:33 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Policosanol and Nattokinase together!

Two HOT Ingredients Together For the First Time!

Policosanol and Nattokinase

23 mg Policosanol
100 mg Nattokinase

Nature's Life Policosanol is standardized to 95% Total Aliphatic Alcohols including 50% Octacosanol. Our Nattokinase supplies 1250 fibrinolytic Units. It is the perfect addition to healthy diet and daily exercise.

Policosanol Extracted from Sugar Caon wax - 50% Octacosanol
Nattokinase derived from natural fermentation of soybeans.

Natures Life Feel the Energy of the Sun!

Supplement Facts:
Serving Size: 2 tablets
Servings per container 25

Nattokinase (Soy bean fibrinase)(Supplying 1250 FU [Fibrionlytic Units]) - 100mg
Policosanol (from Sugar Cane)(Standardized to 95% Total Alcohols including 50% Octacosanol) - 23mg

Other ingredients:

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Nattokinase Fact Sheet

Date: December 08, 2005 05:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Nattokinase Fact Sheet

Nattokinase Fact Sheet

Neil E. Levin, CCN, DANLA 8/8/05

LIKELY USERS: People seeking to support heart health and healthy circulation.1-6

KEY INGREDIENTS: Nattokinase, an enzyme

STRUCTURE/FUNCTION USE: Nattokinase is an enzyme isolated from Natto, a traditional Japanese fermented soy food. Natto has been consumed safely for thousands of years for its numerous health benefits. More recently, both clinical and non-clinical studies have demonstrated that Nattokinase supports heart health and promotes healthy circulation. Each serving of NOWR Nattokinase provides 2,000 FU (fibrinolytic Units) to help keep already healthy levels of blood clotting factors within a normal range. 1-6

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: An assay of 2,000 FU (fibrinolytic Units) is equivalent to 160 IU on the Urokinase assay. The FU assay measures Nattokinase activity by using the fibrin plate method and measuring the absorption of released low-molecular weight substances.7 NOW Nattokinase is made from non-GE (non-genetically engineered) bacteria (Bacillus subtilis var. Natto) grown on non-GE soybeans and standardized on a base of non-GE, corn-derived maltodextrin.

SERVING SIZE & HOW TO TAKE IT: Take one vegetarian Vcap once or twice a day between meals (without protein).

COMPLEMENTARY PRODUCTS: Vein SupremeTM, Tru-E Bio ComplexTM, Pycnogenol®, garlic, and cayenne

CAUTIONS: None.

SPECIFIC: People with blood coagulation disorders or who take anticoagulant (“blood thinning”) medications (including aspirin) should consult a physician before use. Do not take if prone to bleeding. Unlike some other brands, NOWR Nattokinase contains no Vitamin K (K1 or K2), which would enhance clotting.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S (1995) Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull 18(10):1387-1391
2. Sumi H, Hamada H, Nakanishi K, Hiratani H (1990) Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 84(3):139-143.
3. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K (2003) Dietary Supplementation With Fermented Soybeans Suppresses Intimal Thickening. Nutrition 19:261-264.
4. Suzuki Y, Kondo K, Matsumoto Y, Zhao B-Q, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K (2003) Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 73:1289-1298.
5. Ito H, Suzuki T (2002) Effect of oral administration of nattokinase extract on blood mobility. Society of Analytical Bio-Sciences 25(4):1-5.
6. An Open Clinical Pilot Study to Evaluate the Safety and Efficacy of Natural Super Kinase as an Add-On Oral fibrinolytic Agent to Low Molecular Weight Heparin and Anti-Platelets in Acute Ischaemic Stroke. (no authors listed) (2004)
7. Method: J of Agri Food Chem, Vol 48 (2000) P3, 210-213, 216

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Nattokinase - Systemic Enzyme for Healthy Circulation

Date: August 03, 2005 05:38 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Nattokinase - Systemic Enzyme for Healthy Circulation

NEW PRODUCT ANNOUNCEMENT

Nattokinase—100 mg Capsules!

Systemic Enzyme for Healthy Circulation

•A systemic enzyme isolated from the traditional Japanese soy food natto, now available in potent 100 mg capsules.

•Supports cardiovascular health and normal blood flow by assisting in the body’s circulatory clearing system; promotes normal fibrin levels in blood.

•Features high-grade NSK-SD™ NATTOKINASE, the most highly studied form of nattokinase recommended by leading researcher, Dr. Ralph E. Holsworth, Jr.

•Also available in 36 and 50 mg softgels.

1 capsule contains:

Nattokinase (NSK-SD™) 100 mg
providing 2,000 fibrin units (FU) of activity

Suggested Use: 1 capsule three times daily on an empty stomach with 8 ounces of water, or as recommended by your health care professional.

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Serrapeptase - For Serr-ious Sinus Support

Date: July 11, 2005 01:16 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Serrapeptase - For Serr-ious Sinus Support

5 out of 5 Noses prefer Solaray Serrapeptase

For Serr-ious Sinus Support

Discover what noses in Europe and Asia have known for over 25 years -- when it comes to supporting healthy sinuses, there's only one Serrapeptase!

Powerful - Each vegetarian capsule of Serrapeptase contains 2,000 units of enzymatic activity and is enteric-coated for maximum effectiveness. In addition, Serrapeptase is reported to exhibit fibrinolytic activity.

Researched: - The possible health benefits of Serrapeptase have been the subject of many clinical studies in Europe and Asia for over 25 years.

Trusted: - Like all Soaray ® Products, Serrapeptase is producted according to the highest standards of quality and potency.

Serving size:
1 Vegetarian Capsule

Serrapeptase (2,000 Units/mg) 10mg

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Quercetin and Bromelain - for better health.

Date: July 04, 2005 10:28 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Quercetin and Bromelain - for better health.

Maintains Tissue Comfort by Regulating Enzymes*

Helps Maintain Normal Blood Viscosity*

Bromelain May Enhance Quercetin Absorption

Benefits

Down-regulates the Body’s Response to Environmental Challenges Quercetin is a member of the flavonoid family, a diverse group of low molecular-weight compounds found throughout the plant kingdom. Flavonoids exhibit numerous biological activities, many of which are directly beneficial to human health. Quercetin, which belongs to the “flavonol” subgroup, is one of the most versatile and important flavonoids. Quercetin has a broad range of activity, much of which stems from its interaction with calmodulin, a calcium-regulatory protein.1 Calmodulin transports calcium ions across cellular membranes, initiating numerous cellular processes. Quercetin appears to act as a calmodulin antagonist.1 Through this mechanism, quercetin functions at the cell-membrane level with a membrane-stabilizing action.2 Quercetin inhibits calmodulin-dependent enzymes present at cell membranes such as ATPases and phospholipase, thereby influencing membrane permeability.3 Quercetin affects other calmodulin-dependent enzymes that control various cellular functions, including the secretion of histamine from mast cells.4 A number of investigations have corroborated quercetin’s ability to reduce histamine secretion from mast cells in various tissues, and also from basophils.5,6,7,8,9,10

Quercetin modifies the body’s response to antigenic substances.* Suppression of histamine secretion from mast cells is one of quercetin’s most clinically important effects. Quercetin acts on ATPase at the membranes of histamine-containing granules in mast cells.3 Mast-cell degranulation and subsequent release of histamine into the bloodstream is an integral part of the body’s response to environmental challenges.

Maintains Tissue Comfort by Regulating Enzymes*

Quercetin’s enzyme-inhibiting action extends to enzymes such as phospholipase, which catalyzes the release of arachidonic acid from phospholipids stored in cell membranes.4,10 Arachidonic acid serves as the key substrate for substances such as thromboxanes, inflammatory prostaglandins and leukotrienes. In addition, quercetin inhibits the enzymes cyclooxygenase and lipoxygenase, which catalyze the conversion of arachidonic acid into its metabolites.4,10,11,12 Reducing levels of these metabolites, as well as histamine levels, is beneficial in maintaining the normal comfort level of body tissues and structures.

Quercetin has also been shown to limit the function of adhesion molecules on endothelial cells.13 Adhesion molecules are involved in physiologic processes that influence tissue comfort.13

Bromelain is a complex substance derived from the pineapple stem largely composed of proteolytic (protein-digesting) enzymes. Bromelain acts by a variety of mechanisms to help maintain tissues in a normal state of comfort.14,15 Several investigators, including Taussig16 and Ako, et. al.,17 have presented evidence that bromelain is a fibrinolytic agent, i.e., it induces the breakdown of fibrin, a plasma protein that blocks tissue drainage. The generally accepted mechanisms involve direct proteolysis of fibrin by bromelain and activation of plasmin, a serum protease.16 Plasmin acts on fibrinogen (the precursor to fibrin), forming peptides which stimulate PGE1, a prostaglandin that helps maintain tissue comfort.16

Helps Maintain Health of Blood Vessels by Modifying Oxidation of LDL Cholesterol* — Quercetin’s Antioxidant Action Quercetin is a versatile and effective antioxidant that scavenges a variety of free-radicals such as hydroxyl and lipid peroxy radicals.18 Quercetin also chelates ions of transition metals such as iron, which can initiate formation of oxygen free radicals.18 LDL cholesterol is vulnerable to oxidation by lipid peroxides. Oxidized LDL is absorbed by macrophages and arterial endothelial cells, leading to the formation of “foam cells,” and eventually plaque deposits, in arterial walls. Quercetin has been shown to protect LDL from oxidation, both by lipid peroxides and transition metal ions.19

Helps Maintain Normal Blood Viscosity*

Quercetin inhibits blood platelet aggregation (clumping), by potentiating PGI2, an anti-aggregatory prostaglandin, and by raising platelet cyclic AMP levels.20 Human studies have revealed that bromelain also reduces platelet aggregation.21 These properties qualify both quercetin and bromelain as valuable dietary ingredients for maintaining cardiovascular health.*

Bromelain May Enhance Quercetin Absorption

In addition to the actions described above that support the effects of quercetin, bromelain may also assist the absorption of quercetin in the G.I. tract. (Quercetin is generally believed to be poorly absorbed, although a recent study by Hollman et. al.,22 which concluded that humans do in fact absorb appreciable amounts of quercetin, contradicts this assumption.) Studies have shown that bromelain enhances absorption of antibiotics, presumably by increasing permeability of the gut wall.23, 24 Given that quercetin is a low molecular-weight compound, it is plausible that simultaneously ingested bromelain likewise enhances quercetin absorption.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Scientific References

1. Nishino, H., et. al., “Quercetin interacts with calmodulin, a calcium regulatory protein.” Experientia 1984;40:184-5.
2. Busse, W.W., Kopp, D.E., Middleton, E., “Flavonoid modulation of human neutrophil function.” J. Allergy Clin. Immunol. 1984;73:801-9.
3. Havsteen, B,. “Flavonoids, a class of natural products of high pharmacological potency.” Biochemical Pharmacology 1983;32(7):1141-48.
4. Middleton, E., “The Flavonoids.” Trends in Pharmaceutical Sciences 1984;5:335-8.
5. Otsuka, H. et. al., “Histochemical and functional characteristics of metachromatic cells in the nasal epithelium in allergic rhinitis: Studies of nasal scrapings and their dispersed cells.” J. Allergy Clin. Immunol.1995;96:528-36.
6. Fox, C.C., et. al., “Comparison of human lung and intestinal mast cells.” J. Allergy and Clin. Immunol. 1988;81:89-94.
7. Pearce, F.L., Befus, A.D., Bienenstock, J., “Mucosal mast cells III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells.” J. Allergy and Clin. Immunol. 1984;73:819-23.
8. Middleton, E. Drzewiecki, G., Krishnarao, D., “Quercetin: an inhibitor of antigen-induced human basophil histamine release.” J. of Immunology 1981;127(2):546-50.
9. Bennett, J.P., Gomperts, B.D., Wollenweber, E.,“ Inhibitory effects of natural flavonoids on secretion from mast cell and neutrophils.” Arzneim. Forsch/Drug Res. 1981;31(3):433-7.
10. Middleton, E. Drzewiecki G., “Naturally occurring flavonoids and human basophil histamine release.” Int. Archs Allergy appl. Immun. 1985;77:155-7.
11. Yoshimoto, T. et. al., “Flavonoids: potent inhibitors of arachidonate 5-lipoxygenase.” Biochemical and Biophysical Research Communications 1983;116(2):612-18.
12. Della Loggia, R., et. al., “Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase.” Pharmacological Research Communications 1988; 20(Supp. V):91-94.
13. Middleton, E., Suresh, A., “Quercetin inhibits lipopolysaccharide-induced expression of endothelial cell intracellular adhesion molecule-1.” Int. Arch. Allergy Immunol. 1995;107:435-6.
14. Taussig, S.J., Batkin, S., “Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application.” An Update Journal of Ethnopharmacology 1988;22:191-203.
15. Lotz-Winter, H., “On the pharmacology of bromelain: An update with special regard to animal studies on dose-dependent effects.” Planta Medica 1990;56:249-53.
16. Taussig, S.J., “The mechanism of the physiological action of bromelain” Medical Hypothesis 1980;6:99-104.
17. Ako, H. Cheung, A.H.S., Matsuura, P.K., “Isolation of a fibrinolysis activator from commercial bromelain.” Arch. Int. Pharmacodyn. 1981;284:157-67.
18. Afanas’ev, I.B. et. al., “Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation.” Biochemical Pharmacology 1989;38(11):1763-69.
19. De Whalley, C.V., “Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages.” Biochemical Pharmacology 39(11):1743-50.
20. Beretz, A. Stierle, A., Anton, R. Cazenave, J., “Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin.” Biochemical Pharmacology 1981;31(22):3597-600.
21. Heinicke, R. van der Wal, L. Yokoyama, M., “Effect of bromelain (Ananase®) on human platelet aggregation. ”Experientia 1972;28(7):844.
22. Hollma, P. et. al., “Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers.” Am. J. Clin. Nutr. 1995;62:1276-82.
23. Giller, F.B., “The effects of bromelain on levels of penicillin in the cerebrospinal fluid of rabbits.” A., J. Pharm. 1962;134:238-244.
24. Bodi, T., “The effect of oral bromelain on tissue permeability to antibiotics and pain response to bradykinin; double-blind studies on human subjects.” Clin. Med. 1965;72:61-65

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REFERENCES

Date: June 25, 2005 10:35 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: REFERENCES

REFERENCES

1Daniel B. Mowrey. The Scientific Validation of Herbal Medicine. (New Canaan, Connecticut: Keats Publishing, 1986), 122. 2Ibid. 3Earl Mindell. Garlic, The Miracle Nutrient. (New Canaan, C o n n e c t i c u t : Keats Publishing, 1994), 7. 4Ibid., 59. 5Ibid., 71. 6Korotkov, V.M., “The Action of Garlic Juice on Blood Pressure,” Vrachebnoe Deloebnoe, 6, 123, 1966. See also: “The Study of the Hypotensive Action of Garlic Extract in Experimental Animals,” in the Journal of the Pakistan Medical Association, 32 (10), 237-239, 1982. 7A. Bordia and H.C. Bansal. “Essential Oil of Garlic in Pre vention of Atherosclerosis.” Lancet, ii, 1491, 1973. 8Mindell, 58. See The Journal of Nutrition for entries under the subject of garlic. 9Ibid., 59. 10Ibid., 62. See also Nutrition Research for an article published by Doctor Benjamin Lau of Loma Linda University School of Medicine in California. 11Robert H, Garrison Jr., Ma., R.Ph. and Elizabeth Somer, M.A., R.D., The Nutrition Desk Reference. (New Canaan, Connecticut: Keats Publishing, 1990), 193. 12Ibid., 192. 13G. Piotrowski. “L’ail en thrapeutique.” Praxis 37, 488-492, 1948. 14Ibid. 15Mindell, 66. 16D.Y. Norwell and R.S. Tarr. “Garlic, Vampires and CHD,” Osteopath Ann. 1984, 12, 276-80. See also A.K. Bordia, H.K. Josh and Y. K. Sa n a d h y a , “Effect of Garlic OIl on fibrinolytic Activity in patient with CHD.” Atherosclerosis, 1977, 28. 155-59. 17Mindell, 68. 18Garrison, 193. 19Mindell, 70. 20Ibid., 39. 21Ibid. 22Ibid., 49. 23Morton Walker, D.P.M., The Healing Powers of Garlic. (Stanford, Connecticut: A New Way of Life, 1988), 19. 24Ibid. 25Paavo Airola, Ph.D., The Miracle of Garlic. (Phoenix, Arizona: Health Pl u s Publishers, 1978), 20. 26M.N. Fortunatov. “Experimental Use of Phytoncides for Therapeutic and Prophylactic Purpose.” Voprosy pediatri i Okhrany materinstva: Detstva, 20 (2), 1952, 55-58. 27Mindell, 93. 28Louise Tenney. The Encyclopedia of Natural Remedies. (Pleasant Grove, Ut a h : Woodland Publishing, 1995), 57. 29Murray, 258. 30Andrew Weil, M.D., Natural Health, Natural Medicine. (Boston: Houghton-Mifflin Company, 1990), 237. 31Mindell, 97. 32Mowrey, 122. 33Walker, 49.

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GARLIC AS A NATURAL BLOOD THINNER

Date: June 25, 2005 10:03 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GARLIC AS A NATURAL BLOOD THINNER

GARLIC AS A NATURAL BLOOD THINNER

Blood clots pose a significant threat to one’s health and longevity and substantially raise the risk of heart attack or stroke. Blood clots consist of platelets and fibrin. The amount of fibrin in the body is believed to be significantly related to heart attack or stroke risk. In fact, new medical tests are currently being developed to test more carefully for fibrinogen levels in the blood as a predictor for heart attacks and stroke.

The chemical constituents of garlic can actually reduce fibrin formation and help to decrease fibrin that already exists in the blood. Some researchers have even gone as far as to state that Garlic is more effective at preventing blood clots than aspirin therapy.17

Ajoene, a sulfur compound contained in garlic seems to be responsible for its anti-clotting effect. Because ajoene is only viable at room temperature or above, it is not present in raw or freeze-dried garlic. It is believed that adding garlic to the diet can help to increase the breakdown of fibrin from 24 to 130 percent in people who have cardiovascular disease.18

Researchers reported at the First World Congress on garlic that ajoene is such a powerful anti-clotting agent that may prove valuable in cardiac surgeries, including balloon angioplasty, in which blood vessels are artificially dilated to facilitate better blood flow.19

Europeans routinely used garlic as a natural blood thinner which has none of the side-effects associated with synthetic drugs. It should be noted, however, that anyone who suffers form a hemorrhagic disorder (bleeding) should not take commercial garlic products which contain significant amounts of ajoene.

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HIGH BLOOD PRESSURE AND GARLIC THERAPY

Date: June 25, 2005 10:01 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HIGH BLOOD PRESSURE AND GARLIC THERAPY

HIGH BLOOD PRESSURE AND GARLIC THERAPY

Garlic has been used for generations in China and Japan for as a traditional medicine for hypertension. Even today, it continues to be a popular remedy for a disease that has become an epidemic in the western world. Taking a daily dose of garlic can result in a 12 to 30 mmHg reduction is systolic blood pressure and a 7 to 20 mmHg reduction in diastolic pressure in people who suffer from essential hypertension.12

One scientific study revealed that 40 out of 100 patients with high blood pressure experienced a reduction of 20 mmHg or more after a week of garlic treatment.13 Apparently, rabbits and humans who have been tested with garlic have demonstrated a rapid and continued decrease in blood pressure. One reason for this is that garlic seems to dilate blood vessel walls.14 It is the methyl allyl trisulfide contained in garlic which creates this action. Evidently, the effectiveness of using garlic for high blood pressure is dependent to some extent on the type of garlic used. Bulgarian studies suggested that aged Garlic extracts were more effective although this view has been subject to debate. Most practitioners who use garlic for their hypertensive patients recommended a high dosages initially.

In 1992, an article in Planta Medica, a German scientific journal, suggested that gamma-glutamyl-S-allyl-cysteine, a peptide found in Garlic, inhibits a certain enzyme which is involved in the conversion of certain hormones that actually regulate blood pressure. Angiotensin I does not raise blood pressure, however, Angiotensin II can. The peptide found in garlic inhibited the enzyme that changes Angiotensin I into Angiotensin II.15 Consequently, blood pressure levels dropped.

In addition to the actions discussed above, the ajoene compounds in garlic also help to prevent high blood pressure by inhibiting the tendency of blood cells to adhere together and create clots. Garlic oil can increase the breakdown of fibrin by over 100 percent in humans.16 When the blood is discouraged from clotting, blood flow is not restricted, therefore, blood pressure does not rise. Some people who have been on hypertensive drugs have gradually been able to wean themselves off using garlic. If you decide to use garlic for high blood pressure, make sure you check with your doctor and do not abruptly stop taking your medication. (Note: People who have abnormally low blood pressure need not avoid eating garlic. There is evidence to suggest that hypotension benefits from the therapeutic effects of garlic as well as hypertension.

Considering these findings, it would seem that garlic acts to normalize blood pressure whether it be high or low, an action which prescription drugs cannot accomplish.)

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GARLIC (allium sativum)

Date: June 25, 2005 09:54 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GARLIC (allium sativum)

GARLIC (allium sativum)

Common Names: Stinking Rose, Poor Man’s Treacle

Plant Parts: bulb

Active Compounds: Garlic contains more than 200 chemical compounds.

Some of its more important ones include: volatile oil with sulphur-containing compounds: (allicin, alliin, and ajoene), and enzymes: (allinase, peroxidase and myrosinase). Allicin is what gives garlic its antibiotic properties and is responsible for its strong odor. Ajoene contributes to the anticoagulant action of garlic. Garlic also contains citral, geraniol, linalool, Aphellandrene and B phellandrene. The allyl contained in garlic is also found in several members of the onion family and is considered a very valuable therapeutic compound.

Pharmacology: The allicins contained in garlic have a fibrinolytic activity which reduces platelet aggregation by inhibiting prostaglandin E2. Allivium sativum has also exerted some effect on glucose tolerance for both hypo-and hyperglycemia by reducing insulin require-ments to control blood sugar. The compounds contained in garlic have also demonstrated their ability to lower total serum cholesterol and triglyceride levels while elevating HDL levels. LDL synthesis is suppressed by garlic. Garlic allicins have also acted as a larvacide and bacteriostat, active against gram-positive or gram-negative microorganisms. In addition, the compounds can destroy certain fungi such as Candida albicans. Several other microbes are effected by garlic, including some viruses. Most researchers agree that the sulfur containing compounds of garlic, especially allicin, alliin, cy-croalliin, and dialllyldisulphide are the most biochemically active. In addition, certain unidentified substances of garlic will probably emerge as other therapeutic agents.

(Note: Before a bulb of garlic is crushed or chopped, it contains relatively few medically active compounds. Once it is cut, however, chemical reactions take place which create dozens of new compounds.)

Vitamin and Mineral Content: B-vitamins especially B-1, vitamin C, vitamin A, flavonoids, ascorbic acid, phosphorous, potassium, sulphur, selenium, calcium, magnesium, germanium, sodium, iron, manganese and trace iodine. Seventeen amino acids are found in garlic, including eight essential ones.

Character: antibiotic, antihistamine, anticoagulant, expectorant, antibacterial, antiparasitic, alterative, diaphoretic, diuretic , expectorant, stimulant, antispasmodic, promotes sweating, lowers blood sugar and blood cholesterol levels, lowers blood pressure Body Systems Targeted: respiratory, cardiovascular, digestive, and nervous systems

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ENDNOTES

Date: June 23, 2005 11:50 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: ENDNOTES

ENDNOTES

1 G.A. Cordell and O.E. Araujo, “Capsaicin: Identification, nomenclature, and pharmacotherapy.” Ann. Pharmacother. 27: 1993, 330-336.
2 A.Y. Leung. Encyclopedia of Common Natural Ingredients used in Food. (John Wiley and Sons, New York: 1980.
3 Cordell, 330-36.
4 J.J. Jang, D.E. Defor, D.L. Logsdon and J.M. Ward. “A 4-week feeding study of ground red chile (Capsicum annuum) in male mice.” F o o d - C h e m - T o x i c o l . S e p t . 1992 30 (9): 783-7.
5 John R. Christopher. Capsicum. (Christopher Publications, Springville, Utah: 1980), 27.
6 Jack Ritchason. The Little Herb Encyclopedia, 3rd ed. (Woodland Publishing, Pleasant Grove, Utah: 1994), 44.
7 Christopher, 4.
8 Juliette Bairacli-Levy. Common Herbs for Natural Health. (Schocken Books, New York: 1974), 41-43.
9 Charles B. Heiser. Nightshades. (W.H. Freeman, San Francisco: 1969), 18.
10 Lenden H. Smith, M.D., E.P. Donatelle, M.D., Vaughn Bryant, Ph.D. et al. Basic Natural Nutrition. (Woodland Books, Pleasant Grove, Utah: 1984), 157.
11 J. Jurenitsch et al. “Identification of cultivated taxa of Capsicum: taxonomy, anatomy and composition of pungent principle.” Chemical Abstracts. 91 July 30, 1977: 35677g.
12 Daniel B. Mowrey. The Scientific Validation of Herbal Medicine. (Keats Publishing, New Canaan, Connecticut: 1986), 159.
13 Ibid., 208-09.
14 Michael T. Murray. The Healing Power of Herbs, 2nd ed. (Prima Publishing, Prima, California: 1995), 71.
15 J. De Lille and E. Ramirez. “Pharmacodynamic action of the active principles of chile (capsicum annuum L.) Anales Inst. Biol. 1935: 6, 23-37. See also C.C. Toh, T.S. Lee et al. “The pharmacological actions of capsaicin and its analogues.” B r i t i s h Journal of Pharmacology. 1955: 10, 175-182.
16 N.A. Castle. “Differential inhibition of potassium currents in rat ventricular myocytes by capsaicin.” Cardiovasc-Res. Nov. 1992, 26 (11): 1137-44.
17 Murray, The Healing Power of Herbs, 72.
18 Ritchason, 46.
19 T. Kawada, et al. “Effects of capsaicin on lipid metabolism in rates fed a high fat diet.” Journal of Nutrition. 1986: 116, 1272-78. See also J.P. Wang, et al. “Antiplatelet effect of capsaicin.” Thrombosis Res. 1984: 36, 497-507, and S. Visudhiphan, et al. “The relationship between high fibrinolytic activity and daily capsicum ingestion in Thais.” American Journal of Clinical Nutrition. 1982: 35, 1452-58.
20 K. Sambaiah and N. Satyanarayana. “Hpocholesterolemic effect of red pepper and capsaicin.” Indian Journal of Experimental Biology. 1980: 18, 898-99. See also M.R. Srinivasan, et al. “Influence of red pepper and capsaicin on growth, blood constituents and nitrogen balance in rats.” Nutrition Reports International. 1980: 21 (3): 455-67.
21 Mowrey, 12.
22 Ibid.
23 Toh, 175-182.
24 Mowrey, 12.
25 Ibid., 19-20.
26 Louise Tenney. The Encyclopedia of Natural Remedies. (Woodland Publishing, Pleasant Grove, Utah: 1995), 42. See also Peter Holmes. The Energetics of Western Herbs. (Artemis Press, Boulder: 1989), 322.
27 Y. Lee, et al. “Flavonoids and antioxidant activity of fresh pepper (Capsicum annuum) cultivars.” Journal of Food Science. May 1995: 60 (3): 473-76. See also L.R. Howard, et al. “Provitamin A and ascorbic acid content of fresh pepper cultivars (Capsicum annuum) and processed jalapenos.” Journal of Food Science. M a r c h , 1994: 59 (2): 362-65.
28 J.J. Espinosa-Aguirre, et al. “Mutagenic activity of urban air samples and its modulation by chile extracts.” Mutat-Res. Oct. 1993: 303 (2): 55-61.
29 Ibid.
30 Howard, 362-65.
31 Z. Zhang, S.M. Hamilton, et al. “Inhibition of liver microsomal cytochrome P450 activity and metabolism of the tobacco-specific nitrosamine NNK by capsaicin and ellagic acid.” Anticancer-Res. Nov-Dec. 1993: 13 (6A): 2341-46.
32 C.H. Miller, Z. Zhang, et al. “Effects of capsaicin on liver microsomal metabolism of the tobacco-specific nitrosamine NNK.” Cancer-Lett. Nov. 30, 1993: 75 (1): 45- 52.
33 Murray, The Healing Power of Herbs, 71.
34 Cordell, 330-36. See also Murray, The Healing Power of Herbs, 70-71.
35 Murray, The Healing Power of Herbs, 72.
36 C.P.N. Watson, et al. “The post-mastectomy pain syndrome and the effect of topical capsaicin.” Pain. 1989: 38, 177-86. See also C.P.N. Watson and R.J. Evans. “The post-mastectomy pain syndrome and topical capsaicin: A randomized trial.” Pain. 1992: 51, 375-79.
37 Murray, The Healing Power of Herbs, 73.
38 Watson, 177-86.
39 C. Nelson. “Heal the burn: Pepper and lasers in cancer pain therapy.” Journal of the National Cancer Institute. 1994: 86, 1381.
40 Ibid.
41 “The capsaicin study group: Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy.” Diabetes Care. 1992: 15, 159-65. See also R. Tanden, et al. “Topical capsaicin in painful diabetic neuropathy. Effect on sensory function.” Diabetes Care. 1992: 15, 8-14, K.M. Basha and F.W. Whitehouse. “Capsaicin: A therapeutic option for painful diabetic neuropathy.” Henry Ford Hospital Medical Journal. 1991: 39, 138-40, and M.A. Pfeifer, et al. “A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy.” Diabetes Care. 1993: 16, 1103-15.
42 R. Tanden, et al. “Topical capsaicin in painful diabetic neuropathy: controlled study with long- term follow-up.” Diabetes Care. Jan. 1992: 15 (1): 8-14.
43 Ibid.
44 J.E. Bernstein, et al. “Topical capsaicin treatment of chronic post-herpetic neuralgia (shingles) with topical capsaicin. A preliminary study. Journal of American Academy of Dermatologists. 1987: 17, 93-96. See also Murray, The Healing Power of Herbs, 72.
45 Sid Kircheimer. The Doctor’s Book of Home Remedies. (Rodale Press, Emmaus, Pennsylvania: 1993), 228.
46 Murray, The Healing Power of Herbs, 74.
47 G.M. McCarthy and D.J. McCarty. “Effect of topical capsaicin in therapy of painful osteoarthritis of the hands.” Journal Rheumatol. 1992: 19, 604-07. See also C. L Deal, et al. “Treatment of arthritis with topical capsaicin: A double blind trial.” Clinical Therapy. 1991: 13, 383-95.
48 Murray, The Healing Power of Herbs, 74.
49 Kircheimer, 14.
50 Murray, The Healing Power of Herbs, 74.
51 Michael T. Murray, N.D. and Joseph Pizzorno, N.D. Encyclopedia of Natural Medicine. (Prima Publishing, Rocklin, California: 1991), 419.
52 J. Y. Kang, et al. “The effect of chile ingestion of gastrointestinal mucosal proliferation and azoxymethane-induced cancer in the rat.” Journal of Gastroenterology- Hepatol. Mar-Apr. 1992: 7 (2): 194-98.
53 K. G. Yeoh, et al. “Chile protects against aspirin-induced gastroduodenal mucosal injury in humans.” Dig-Dis-Sci. Mar. 1995: 40 (3): 580-83.
54 Ibid.
55 Ibid.
56 L. Limlomwongse, et al. “Effect of capsaicin on gastric acid secretion and mucosal blood flow in the rat.” Journal of Nutrition. 1979: 109, 773-
77. See also T. Kolatat and D. Chungcharcon. “The effect of capsaicin on smooth muscle and blood flow of the stomach and the intestine.” Siriraj Hospital Gazette. 1972: 24, 1405-18, O. Ketusinh, et al. “Influence of capsaicin solution on gastric acidities.” A m e r i c a n Journal of Proceedings. 1966: 17, 511-15, and Mowrey, 48.
57 Mowrey, 48 and Limlomwongse, 773-77.
58 M. Horowitz, et al. “The effect of chile on gastrointestinal transit.” Journal of Gastroenterology-Hepatol. Jan-Feb, 1992 7 (1): 52-56.:
59 Christopher Hobbs. “Cayenne, This Popular Herb is Hot.” Let’s Live. April 1994: 55.
60 V. Badmaev and M. Majeed. “Weight loss, the Ayurvedic system.” Total Health. Aug, 1995: 17 (4): 32-35.
61 Murray, The Healing Power of Herbs, 75.
62 C.N. Ellis, et al. “A double-blind evaluation of topical capsaicin in pruritic psoriasis.” Journal of the American Academy of Dermatology. 1993: 29 (3): 438-42.
63 Murray, The Healing Power of Herbs, 75.
64 S. Marabini, et al. “Beneficial effect of intranasal applications of capsaicin in patients with vasomotor rhinitis.” Eur Arch-Otorhinolaryngol. 1991: 248 (4): 191-94.
65 Ibid.
66 Mowrey, 242.
67B. Dib. “Effects of intrathecal capsaicin on autonomic and behavioral heat loss responses in the rat. Pharmacol Biochem Behav. 1987: 28, 65-70.
68 Murray, The Healing Power of Herbs, 72.
69 Christopher, 31.
70 M. Ponce, et al. “ In vitro effect against giardia of 14 plant extracts.” Rev-Invest-Clin. Sept- Oct. 1994: 46 (5): 343-47.
71 Ibid.
72 Humbart Santillo. Natural Healing with Herbs. (Hohm Press, Prescott, Arizona: 1993), 100.
73 Daniel B. Mowrey. “Capsicum ginseng and gotu kola in combination.” The Herbalist premier issue, 1975: 22-28.
74 Ibid.
75 Mowrey, The Scientific Validation of Herbal Medicine, 102.
76 J. Roquebert, et al. “Study of vasculotropic properties of Capsicum annuum.” Annales Pharmaceutiques Francaises. 1978: 36 (7-8): 361-68.
77 Rita Elkins. Depression and Natural Medicine. (Woodland Publishing, Pleasant Grove, Utah: 1995), 161.

--
Vitanet ®

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Bromelain Sinus Ease - Nature's Life

Date: June 16, 2005 10:57 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Bromelain Sinus Ease - Nature's Life

Bromelain Sinus Ease™

Nature's Life Sinus Products:

Sinus cavities are lined with delicate mucous membranes, which act as filters for your respiratory system. Normal sinuse tissues are pink and healthy. For many people, when their sinuses come in contact with allergens, pollutants or harmful micro-organisms, histamines are released as a protective measure by the immune system. Sinuses naturally respond by becoming irritated, red, and inflamed with these healing histamines. This process, called the natural inflammatory response, helps to neutralize and remove the irritants in sinuses cavities. Sometimes, however, the immune system continues to flood the sinuses even after the irritants are removed. Bromelain Sinus Ease™ contains three ingredients that have been shown to enhance the body’s ability to reduce this natural inflammatory response and help clear up sinuses.*

Bromelain

Bromelain is a group of protein-digesting enzymes extracted from pineapples (Ananassa sativa). Bromelain breaks down fibrin—a key component of the body’s natural inflammatory response to allergens and other foreign stimuli.* Bromelain also appears to inhibit the natural formation of prostaglandins (hormone-like substances) that trigger the natural inflammatory response.*1 It makes mucus less thick,2 allowing the mucus to drain more easily.*

Human trials have shown that by breaking down and helping to remove fibrin, bromelain reduces the discomfort of irritated tissues.*3 Double-blinded trials in patients with irritated sinuses show that the natural inflammatory response is reduced more effectively by concentrated bromelain than by placebo.*4 ,5 ,6 ,7 In all cases, a majority of people responded well to bromelain supplements.*

Bromelain has also helped reduce the duration of the natural inflammatory response after nasal procedures by over 70% in a controlled trial.*8

The recommended daily amount of Nature’s Life Sinus Ease™ utilizes 1,200 mg a very high potency bromelain enzyme which has an activity of 2,880 GDU (Gelatin Digestive Units), or 4,320 MCU (Milk Clotting Units) per serving.

Vitamin C

Vitamin C also helps reduce histamine release.*9 Some studies have reported that vitamin C is useful in reducing the natural inflammatory response in nasal passages.*10, 11, 12 The effectiveness of vitamin C in reducing histamine release is still debated, however, because a controlled trial was unable to show consistent effects.*13 Doses up to 2 grams per day have been used by researchers. It may be difficult to show these effects in research trials because vitamin C appears to help only some people without affecting others.*14 Studies, however, clearly show that vitamin C supplementation can lower elevated blood levels of histamines.*15, 16 Nature’s Life adds naturally-buffered vitamin C to Sinus Ease due to its safety, immune-supporting effects and potential efficacy to reduce histamine release.*

Quercetin is a bioflavonoid found in many natural foods including citrus fruits, onions, apples, tea and lettuce. As with bromelain, quercetin helps reduce the natural inflammatory response by inhibiting the natural formation of the pro-inflammatory agents, prostaglandins and leukotrienes (white blood cells).*17,18 Quercetin also helps lessen the natural inflammatory response for children with sensitivities to inhalants.*19 Additionally, quercetin may help reduce the effects of harmful micro-organisms *20 Bioflavonoids at doses of 1,200 mg per day have reduced the natural inflammatory response in human studies in combination with 1,200 mg vitamin C,21 an outcome confirmed in double-blinded research using 600 mg/day of bioflavonoids and 450 mg/day of vitamin C.*22

Substances which inhibit the natural inflammatory response rarely target just one part of the body.* While quercetin has yet to be tested in reducing the natural inflammatory response in sinuses specifically, doctors of natural medicine frequently use it for that purpose because of its proven ability to lessen the natural inflammatory response elsewhere in the body.*

Nature’s Life Sinus Ease™

Nature’s Life has combined these powerful phytonutrients to make Sinus Ease™. High potency Bromelain, Quercetin and vitamin C work to inhibit the natural pro-inflammatory response and encourage adequate sinus drainage.* No safety concerns have been identified with any of these ingredients.23, 24 It is recommended to take the three capsules per day between meals. Since bromelain is a proteolytic enzyme, if taken with a meal it will act on the protein in the food rather than the natural pro-inflammatory fibrin, so remember to take it between meals.* Enjoy the winter season and find relief from allergens throughout the year! Nature’s Life Sinus Ease™ can help.

References:

Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypoth 1980;6:99-104.
Martin GJ. Bromelain pineapple proteases with anti-edema activity. Exper Med Surg 1962;20:228-48.
Blonstein JL. Control of swelling in boxing injuries. Practitioner 1969;203:206.
Seltzer AP. Adjunctive use of bromelains in sinusitis: a controlled study. EENT Monthly 1967;46:1281-8.
Taub SJ. The use of Ananase in sinusitis—a study of 60 patients. EENT Monthly 1966;45:96-8.
Ryan RE. A double-blind clinical evaluation of bromelains in the treatment of acute sinusitis. Headache 1967;7:13-7.
Taub SJ. The use of bromelains in sinusitis: a double-blind clinical evaluation. EENT Monthly 1967;46:361-5.
Seltzer AP. Minimizing post-operative edema and ecchymoses by the use of an oral enzyme preparation (bromelain). EENT Monthly 1962;41:813-7.
Johnson CS, Martin LJ, Cai X. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr 1992;11:172-6.
Zuskin E, Lewis AJ, Bouhuys A. Inhibition of histamine-induced airways constriction by ascorbic acid. J Allergy Clin Immunol 1973;51:218.
Ruskin SL. High dose vitamin C in allergy. Am J Dig Dis 1945;12:281.
Holmes HN. Hay fever and vitamin C. Science 1942;96;497.
Fortner BR, Danziger RE, Rabinowitz PS, Nelson HS. The effect of ascorbic acid on cutaneous and nasal response to histamine and allergen. J Allergy Clin Immunol 1982;69:484-8.
Bai TR, Martin JG. Effects of indomethacin and ascorbic acid on histamine induced bronchoconstriction in normal subjects. NZ Med J 1986;99:163 [abstr].
Holmes H, Alexander W. Hay Fever and Vitamin C. Science 1942;96:497-99.
Johnston CS, Martin LJ, Xi C. Antihistamine Effect of Supplemental Ascorbic Acid and Neutrophil Chemotaxis. J Am Coll Nutr 1992;11:172-6.
Middleton E, Drzewieki G. Naturally occurring flavonoids and human basophil histamine release. Arch Allergy Applied Immunol 1985;77:155-7.
Welton AF, Tobias LD, Fiedler-Nagy C, et al. Effect of flavonoids on arachidonic acid metabolism. Prog Clin BiolRes 1986;213:231-42
Balabokin II, Gordeeva GF, Fuseva ED, et al. Use of vitamins in allergic illnesses in children. Vopr Med Khim (Russia) 1992;38:36-40.
Ohnishi E, Bannai H. Quercetin potentiates TNF-induced antiviral activity. Antiviral Res 1993;22:327-31.
Miller MJ. Injuries to athletes. Med Times 1960;88:313-6.
Cragin RB. The use of bioflavonoids in the prevention and treatment of athletic injuries. Med Times 1962;529-32.
Taussig SJ, Yokoyama MM, Chinen N, et al. Bromelain: A proteolytic enzyme and its clinical application. Hiroshima J Med Sci 1975;24:185-193.
Hertog MGL, Feskens EJM, Holman PCH, et al. Dietary flavonoids and cancer risk in the Zutphen elderly study. Nutr Cancer 1994;22:175-84.