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What Are The Health Benefits Of Indole-3-Carbinol?

Indole-3-Carbinol

Indole-3-Carbinol is a substance that is mainly found in cruciferous vegetables. It is produced through the breaking down of glucosinolates. It has varied health benefits in the body. It has anti-cancer properties and it also works as an antioxidant. It is mainly found in cauliflower, broccoli, Brussels sprouts and cabbage.

Most of the health benefits of Indole-3-Carbinol are realized in women. Oral ingestion alters estrogen metabolism in an advantageous manner. It blocks the estrogen receptor site and this reduces the risk of cancer.

Cancer

The anticancer effect of Indole-3-Carbinol is as a result of activities like enhanced DNA repair which induces the arrest of G1 cell cycle and apoptosis. It also enhances the production of enzymes that that play a role in metabolizing carcinogens.

Indole-3-Carbinol together with its metabolite diindoylmethane modulates some transcription factors. This leads to a number of biochemical and biological effects. It works as an antioxidant and thus provides protection to the DNA as well as other cell structures.

It also has chemo preventive activity. This stimulates the body to produce detoxifying enzymes. This protects against the carcinogenic effects of toxins like pesticides.