Active CoQ10

 

The benefits of Coenzyme Q10 have become increasingly well-known. This important nutrient has been shown in clinical trials to improve heart function, reduce the side effects of certain drugs used to treat cancer, and slow the progression of serious brain diseases such as Parkinson’s disease. Now research has opened a new chapter in the CoQ10 story, highlighting the benefits of ubiquinol, the active form of CoQ10, to increase energy and stamina, and reduce some of he physical signs of aging.

In this issue of Ask the Doctor we will review the benefits of Coenzyme Q10, and discuss the differences between CoQ10 and its active form –ubiquinol.

 

Q. What is CoQ10?

A. CoQ10 is a natural, fat-soluble nutrient present in virtually all cells. CoQ10 also is known as ubiquinone. That’s because CoQ10 is ubiquitious and exists everywhere there is life. CoQ10 is vital to adenosine triphosphate (ATP) production. ATP is the energy-rich compound used for all processes requiring energy in the body. Although CoQ10 is produced by the body and exists in some limited dietary sources, these levels may be insufficient to meet the body’s requirements. CoQ10 levels diminish with age and as a result of dietary inadequacies and various disease states. Also, some drugs, especially a group of cholesterol lowering prescription drugs known as “statins,” (Pravachol, Zocor, Lipitor, etc.) significantly reduce CoQ10 levels in the body.

 

Q. What is ubiquinol? Is it the same or different from CoQ10?

A. Ubiquinol and CoQ10 are very closely related. Ubiquinone, or CoQ10, is the oxidized form of the molecule. This means it has to be converted to a non-oxidized form before it can perform its work. Ubiquinol is the active form of this nutrient. Our bodies convert CoQ10 to ubiquinol – which is the form needed to produce cellular energy. Until recently, it was not possible to use ubiquinol as a supplement because it is very unstable outside the human body. But research has now found a way to keep this molecule stable so it can be successfully taken in supplement form.

 

Q. If CoQ10 gets converted to ubiquinol anyway, can’t I just take CoQ10?

A. While it is true that our bodies can convert CoQ10 to ubiquinol, it isn’t true that we all do this equally well. In fact, as we age, our ability to convert CoQ10 to ubiquinol declines. And some people even have a gene that makes them less effective at this conversion than the majority of the population. IN fact, several common health issues have been associated with less than optimal ratios of CoQ10 to QH. For healthy people the ideal ratio is approximately 97% Ubiquinol to 3% CoQ10. But in people with diabetes, for example, the ratios have been found to range from 43% ubiquinol to 47% CoQ10 in mild diabetes, to only 24% ubiquinol to 76% CoQ10 in severe diabetes. These numbers are for men; the numbers for women vary by 2 to 5 percentage points.

So for older folks, the 30-50% of people who have the gene that impairs CoQ10 conversion, or for people who have serious health concerns, supplementing with ubiquinol instead of CoQ10 might be the smart choice.

 

Q. What are the health benefits of CoQ10 and Ubiquinol?

A. There have been many studies showing that CoQ10 is beneficial in treating and preventing heart disease and conditions such as high blood pressure atherosclerosis (hardening of the arteries), angina, and congestive heart failure (CHF). It’s been shown that heart attacks tend to occur when CoQ10 levels are low in the body. Exciting new research has found that CoQ10 in a unique delivery system supplementation may slow the progression of symptoms associated with neurological diseases such as Parkinson’s disease, ALS, Huntington’s disease and Alzheimer’s disease.

In addition, CoQ10 is beneficial for diabetes, immune dysfunction, cancer, periodontal disease, prostate cancer, and neurological disease. While the research on ubiquinol is still very new, it is reasonable to expect that its benefits will be equal to or perhaps even better than CoQ10, because it is the more active form.

 

Q. Why is CoQ10 especially important for preventing and treating heart disease, and for neurological diseases like Parkinson’s disease?

A. The heart and brain are some of the most metabolically active tissues in the body. Both require large amounts of uninterrupted energy, which means these tissues also need increased amounts of ubiquinol. Research has shown that many people with heart of brain diseases have serum CoQ10 levels that are lower than those of healthy people. Correcting such deficiencies often can produce significant results. However, these diseases become more common as we age – right at the time our ability to convert CoQ10 to its active form, ubiquinol, declines.

 

Q. How might ubiquinol be important for the heart?

A. Heart Health: A study on patients admitted to the hospital with an acute myocardial infarction (AMI) found that CoQ10 can provide rapid protective effects in patients with a heart attack if administered within three days of the onset of symptoms. Seventy-three patients received CoQ10 (120 mg/d). The study’s control group consisted of 71 similarly matched patients with acute AMI. After treatment, angina pectoris (severe chest pain signifying interrupted blood flow to the heart), total arrhythmias (dangerously irregular heartbeats), and poor function in the left ventricle (the essential chamber of the heart) were significantly reduced in the CoQ10 group compared to the placebo group. Total deaths due to sudden cardiac failure and nonfatal heart attacks also were significantly reduced in the CoQ10 group compared with the placebo group.

In another study, CoQ10 was studied in 109 patients with high blood pressure (hypertension). The patients were given varying doses of supplemental CoQ10 with the goal of attaining a certain blood level (greater than 2.0 mcg/l). Most patients were on medications to treat hypertension. Half the patients were able to stop taking some or all of their prescription drugs at an average of 4.4 months after starting CoQ10. The 9.4% of patients who had echocardiograms, performed both before and during treatment, experienced a highly significant improvement in heart wall thickness and function. This improvement was directly attributed to CoQ10 supplementation.

Congestive heart failure (CHF) is a debilitating disease that affects 5 million people in the U.S. It causes edema, difficult breathing, and impaired circulation. In another study, CoQ10 restored healthy heart function in CHF patients. Patients received 100 mg of CoQ10 or a placebo twice daily for 12 weeks. Before and after the treatment period, the investigators introduced a catheter into the right ventricle of patients’ hearts to determine the degree of CHF damage to the heart muscle. The patients’ heart muscles at rest and work improved significantly. The researchers concluded CHF patients would greatly benefit from adjunctive CoQ10 treatment. Since ubiquinol is the active form of CoQ10, it may be able to overcome the hurdles to providing maximum impact, most importantly, age and genetic related inefficiencies in converting CoQ10 to active CoQ10 (Ubiquinol).

 

And Neurological Health?: A study sponsored by the National Institutes of Health showed that supplementing with CoQ10 in a unique delivery system was associated with a slowing of the progression of Parkinson’s disease. Participants were divided into 4 groups and their physical skills (coordination, walking, etc) and mental skills were evaluated. Each group then received 300 mg, 600 mg, or 1200 mg of a special form of Chewable CoQ10, or a placebo. The researchers evaluated the participants after 1, 4,8, 12, and 16 months of treatment. Each participant was again scored on motor, mental, and activities of daily living skills.

The results of the study showed that the people who took the highest dosage of CoQ10-1200 mg-experienced the least decline in their physical abilities. The results were so encouraging that the researchers will be continuing with new studies, suing higher dosages to see if the results can get even better.

Huntington’s disease (HD) is a devastating and degenerative inherited disease that is always fatal. In fact, no other medication, drug, or nutritional supplement has ever been shown to cause a decline in the progression of this terrible disease. A study compared CoQ10 against remacemide (an investigational HD drug made by AstraZeneca Pharmaceuticals), in 347 HD patients who were in the early stages of the disease. Remacemide blocks glutamate, the neurotransmitter scientists think may cause the death of brain cells that occurs in Huntington’s disease. While remacemide had no effect on the progression of HD, CoQ10 showed a trend toward slowing the disease by an average of 15%. This meant the HD group taking CoQ10 was able to handle every day activities of life a little longer than the patients taking remacemide or a placebo. They also were able to focus their attention better, were less depressed, and less irritable.

The 15% slowing of decline can result in about one more year of independence of HD patients. Needless to say, the gift of an additional year of health in the lives of HD patients is incredibly significant.

Because of these impressive results, researchers are hopeful that supplemental CoQ10 will have beneficial effects for people with other neurological diseases such as ALS and Alzheimer’s disease, too. Studies are under way to confirm these effects.

Using the active form of CoQ10 helps to assure that, regardless of age or illness, the CoQ10 can have the greatest impact.

 

Q. What have been the results of research studies with Ubiquinol?

A. One of the most interesting effects of Ubiquinol that has been reported so far is its ability to slow the physical signs of aging. In laboratory studies, administration of stable ubiquinol to mice forestalled the changes associated with aging – rounded spine, patchy fur and irritated eyes. While the mice who received ubiquinol did not necessarily live longer than the mice that didn’t, they lived better. But it is important to note that these mice were bred to die at a young age. Human studies are needed to determined true impact on longevity.

Additionally, supplemental, stable ubiquinol has been shown to increase physical energy and stamina. In an animal study, the length of time rats were able to run on a treadmill before getting tired was measured. The same rats were then given ubiquinol and the treadmill test was repeated. The length of time the rats were able to run before tiring increased 150 times.

 

Q. How can one supplement have applications for neurological diseases, heart health, and even the immune system?

A. Supplements often have more than one function, especially when it’s a substance like CoQ10, which is present in all parts of the body. All nucleated cells (most cells other than red blood cells) have mitochondria and all cells require energy to function. CoQ10 is vital to ATP production. Thus, CoQ10 has applications not only in neurological (neurons or nervous system cells) and cardiac health (myocardium or heart tissue), but also for the immune system.

 

Q. Should I take CoQ10 or ubiquinol? How much should I take?

A. While everyone can benefit from CoQ10 or ubiquinol supplementation, it appears that ubiquinol should be the first choice for older adults, people with known genetic inefficiencies in converting CoQ10 to ubiquinol, and for people with serious heart disease or neurological diseases such as Parkinson’s disease, who are otherwise supplementing with high levels of CoQ10. For people in overall good health, a high quality CoQ10 supplement with proven absorption is a good choice.

Take 200 to 300 mg of CoQ10 or 100 mg ubiquinol daily, depending on your health history. The safety of both forms has been tested, and no significant side effects reported. Occasional mild stomach upset may occur. Taking your CoQ10 or ubiquinol with meals usually alleviates this rare effect.

 

Conclusion
CoQ10 is not the only answer to the complex issues of heart disease, neurological diseases, or immune dysfunction; however, research indicates that it’s a bigger piece of the puzzle than physicians and scientists ever imagines. The more we study this naturally occurring compound, the more benefits we find. And with this new ability to provide CoQ10 in its active form, ubiquinol, for the first time, even greater benefits may be derived.

Supplements for Children

 

While most parents try hard to make nutritious meals for their family, most children find the appeal of refined, fast, and junk food simply overwhelming. And, sadly, increasingly easy to buy and consume, as well. From kindergarten through 12^th grade, in both grade schools and high schools, vending machines offer calorie laden candy bars, sugar-filled soft drinks, and snack foods loaded with fat and salt. Many school cafeterias actually sell fast-food to children for lunch every day. In fact, it seems almost everywhere children go and gather, visually enticing but nutritionally lacking snacks and soft drinks are sure to be available.

Determined to counteract this disturbing trend, parents everywhere are urgently seeking solutions to help their children get the nutrition they need. One answer is supplemental multivitamins. There are certainly plenty of multivitamins formulated for children currently on the market. However, these products vary considerably in quality and content. Some lack certain vital nutrients. Some taste terrible. Still others are loaded with sugar and artificial flavorings. The good news is that there are superior multivitamins and exceptional immune boosting products formulated specifically for children that actually taste great. In this issue of Ask the Doctor, we will discuss childhood nutrition and how to help ensure your children’s health with high quality, 100% natural flavored nutritional supplements.

 

Q. Do children really benefit from vitamin supplements? Can’t I make sure they get the vitamins and minerals they need from meals?

A. Even the most nutritionally vigilant parent cannot be 100% certain what nutrients are in the food they serve their children. That’s because there’s so much variability in the food we prepare. For instance, fat-soluble vitamins can withstand normal cooking, but vitamins A and E are gradually destroyed by exposure to air. Water-soluble vitamins such as B1, B6, folic acid, and pantothenic acid are destroyed by heat. Vitamin B2 is destroyed by light and heat, while light and air destroy vitamin C. Certain food preservatives and preparation methods also destroy the vitamins in food. To further complicate matters, some fruit and vegetables are grown and harvested in such a way that does not promote nutrient content – so even raw foods may be lacking.

Then there are those crazy food phases all children seemingly go through. While these phases are generally harmless in the long run, a recent alarming exception was in the news. A five-year old boy ate nothing but cheese pizza, Pop-tarts, biscuits, and water, refusing fruits, vegetables, juices and vitamins. He slowly developed limp, swollen gums, and small purple spots appeared on his skin. After five months of this extremely deficient diet, he was unable to walk or get out of bed because the pain was so severe. Doctors diagnosed the boy as having a severe vitamin C deficiency after ruling out other ailments such as leukemia. Within a week of getting vitamin C supplements, the boy’s pain and other symptoms were completely resolved. Obviously, this little boy’s story is unusual. However, even mild food phases (such as “If It’s Green It Must Be Yucky” or “The Only Good Crust Is A Cut-Off Crust”) can result in awfully lop-sided nutrition.

 

Q. Can multivitamins help my child’s performance in school?

A. Most teachers firmly believe that nutrition and learning go hand in hand. They are convinced that children who are well nourished possess the mental stamina that’s needed to learn and retain even difficult concepts. But can multivitamins help children become better students?

Two independent research teams recently conducted randomized trials to find the answer. The researchers followed 245 school-children aged 6 to 12 years for three months. They gave half of the children multivitamin tablets every day, and half of the children placebos. When the children were tested, the children in the multivitamins group showed an increase in their nonverbal intelligence scores. Nonverbal intelligence is closely associated with academic performance.

 

Q. I can’t get my children to take 100% natural flavored multivitamins because they don’t taste very appealing. Isn’t there some way to make a 100% natural multivitamin taste good enough for my children to willingly take?

A. Yes, there is! Because most children need Chewable multivitamins, manufacturers need to contend with the truly terrible taste of certain minerals. Magnesium, iodine, copper, and iron are probably the worst tasting. Some solve this dilemma by skimping on the amounts of these minerals in their children’s formulas. Others cover up the bad taste with either massive amounts of sugar or artificial flavors, or both.

However, a select few multivitamin makers have discovered how to offer a natural flavored, great tasting children’s multivitamin that contains these vital minerals. The best children’s vitamins are prepared in a base of natural fruit that provides both antioxidants and other healthy phytonutrients. Children’s multivitamins made in such a fruit base have very low sugar content, as well, providing as little as four calories a day. Fructose – fruit sugar – is the preferred sweetening agent, in addition to the fruit content.

 

Q. What vitamins should be in a multivitamin for children?

A. There are several vitamins and minerals that children need to take each and every day. They include biotin, folate, niacin, pantothenic acid, vitamins B12, B1, A, B6, C, D, E, and K. Let’s review a few. We’ll start with folate, one of the B vitamins. This vital vitamin helps the body use protein, helps make DNA, helps cells grow and divide, and keeps the nervous system healthy. In fact, folate is so important to children that the Food and Drug Administration (FDA) mandated that folate must be added to many foods most children eat daily. Since 1998, cereal, enriched bread, flour corn meal, rice, and pasta have been folate-fortified with this B vitamin.

One of folate’s vital actions is the reduction of homocysteine levels in the blood. Homocysteine is an amino acid (the building block of protein) that is normally produced in the human body. Research has shown that high levels of homocysteine can irritate blood vessels, make blood clot more easily than it should, and cause blockages in arteries increasing the risk of heart attacks and strokes .

However, study after study has proven that taking folate reduces harmful homocysteine levels. While most of this research has been in adults, a recent study looked at children’s homocysteine levels. Researchers examined over 3500 children and discovered that high homocysteine levels increased the risk for heart disease in these children, especially as they grow. The researchers leading this study reinforced how critical folate is for all children.

Other critical vitamins for children are the vitamins C and E. The rates of childhood asthma have increased significantly here in the US. There seem to be several reasons for this troubling trend, including environmental pollution and changes in the earth’s atmosphere. However, when vitamin C and vitamin E are given to children with asthma, they are able to breathe better and feel much better, too. It seems C and E, both antioxidants, keep asthmatic bronchial tubes from constricting which results in wheezing less and breathing better.

 

Q. Which minerals do children need?

A. It is absolutely crucial that children get calcium, chromium, iron, magnesium, manganese, selenium, zinc, and phosphorus every day. Sadly, however, the majority of our children are not getting the recommended amounts of many of these vital minerals. Children in America today drink more carbonated soft drinks than milk and are in the midst of a calcium crisis. Green leafy vegetables, another good calcium source, are also negligible in teen diets.

According to statistics from the National Institutes of Health, only 13.5 percent of girls and 36.3 percent of boys age 12 to 19 in the United States get the recommended daily amount (RDA) of calcium. Because almost 90 percent of adult bone mass is established by the end of this age range, children today are in danger of being part of an osteoporosis epidemic in the future as they enter late adulthood.

Lack of adequate calcium has immediate consequences for children, as well. The number of fractures among children and young adults has increased as a direct result of poor calcium intake. Pediatricians are also seeing children with rickets, a bone disease caused by low levels of vitamin D. Rickets became almost nonexistent after vitamin D was added to milk in the 1950s, but, due to lower milk consumption, is now appearing at greater rates around the country. And milk itself can be problematic for some children. Aside from alarming reports of hormones and herbicides in commercial dairy factory milk, even organic milk is not tolerated by all because of lactose intolerance and allergies.

Zinc is another mineral that’s vital for children. Because zinc is critical for normal growth and development, children need to take it every day. A study published in the Journal of the American Dietetic Association, however, found more than half of US children ages two to 10 years fail to get the recommended daily allowance (RDA) for zinc. What’s even more troubling is that zinc is vitally connected to children’s ability to process information, pay attention, as well as remember and retain new information

Zinc does a lot to keep children healthy. More than 200 enzymes in our bodies rely on zinc. However, it’s zinc’s ability to connect with our immune systems to help fight infections that is crucial for children. While researchers are not certain how zinc precisely boosts a child’s immunity, they think that zinc might fight pneumonia and other infections by either enhancing the body’s immune status, preventing the infection from establishing itself, or improving the immune system’s ability to rid itself of the infecting organism. It’s possible that zinc does all three.

 

Q. No matter what I do, my children seem to come down with bad colds each year. Besides giving them a multivitamin, are there other nutritional supplements that can keep my children healthy?

A. Absolutely! In fact, there are 100% natural flavored children’s immune formula nutritional supplements that contain their good buddy zinc, vitamins B6, C, and A (as beta carotene), plus elderberry extract. Elderberry extract has been used as a traditional medicine for hundreds of years to treat colds and flu. And as it so often happens, scientific research has validated this use. In fact, scientists have discovered that elderberry keeps viruses from invading other cells and replicating. It also spurs important immune cells into action to fight invading germs.

While we previously discussed vitamin C’s ability to help children with asthma breathe easier, it also provides powerful immune protection. It speeds up the healing of wounds, such as those knee and elbow scrapes so common in childhood. However, vitamin C is a water-soluble vitamin and can’t be stored in the body. It must be replenished every day. When children are under increased stress (like when they get sick with a cold or flu), their vitamin C levels are more rapidly depleted.

Vitamin B6 is also water-soluble and can only work in children’s bodies for eight hours. Then more B6 must be obtained. Vitamin B6 strengthens the immune system by helping white blood cells make antibodies. Vitamin A helps make lysozymes, important anti-infectious agents found in tears, saliva, and sweat. It also stimulates the thymus gland, an important immune organ, especially in children, to work better.

 

Q. Should children take an immune formula every day or only when they are sick?

A. It can be taken several ways. Some parents may want to give the formula when school first starts or other times that their children are exposed to lots of germs. For a child who suffers from asthma or seasonal allergies or just seems to get sick frequently, parents could provide the immune formula every day, increasing the dose when needed. And still others might feel it’s best to give their children the immune formula only whey they do catch a cold or have the flu.

No matter how it is given, the 100% all natural flavored, immune boosting nutritional supplement can provide powerful protection against all those disease-causing germs your children are exposed to every day.

 

Conclusion

The nutritional choices we make for our children today will have a profound effect on their health tomorrow. Recent research has revealed that diabetes, heart disease, obesity, osteoporosis, and cancer in adults often result form nutritional deficiencies that occurred in childhood.

Thankfully, the reverse is just as true. This means that children who are well nourished with an optimal intake of minerals, vitamins, and helpful herbs can grow into healthy and happy adults. Providing high quality multivitamins and immune boosting nutritional supplements for our children can be an important part of that process.

 

CoQ10 for Heart Health

 

More than 40% of all deaths in the U.S. are from cardiovascular disease (CVD). You have a greater chance of dying from heart disease than from cancer, AIDS, diabetes, and accidents combined. More than 2,600 Americans die each day of CVD – an average of 1 death every 33 seconds. One in 5 men and women have some form of CVD. If all forms of major CVD were eliminated, life expectancy would rise by almost 7 years.

One of the most – if not the most – important things people can do to improve their overall health and life expectancy is to improve their heart health. Diet, exercise, and the wise use of dietary supplements can improve heart health dramatically. One dietary supplement that’s extremely beneficial to heart health is coenzyme Q10 (CoQ10).

 

Q. What is CoQ10?

A. CoQ10 is a natural, fat-soluble nutrient present in virtually all cells. CoQ10 also is known as ubiquinone. That’s because CoQ10 is ubiquitous and exists everywhere there is life. CoQ10 is vital to adenosine triphosphate (ATP) production. ATP is the energy-rich compound used for all energy-requiring processes in the body. Although COQ10 is produced by the body and exists in some dietary sources, these levels may be insufficient to meet the body’s requirements. CoQ10 levels diminish with age and as a result of dietary inadequacies and various disease states. Also, some drugs, especially a group of cholesterol-lowering prescription drugs known as “statin,” (Pravachol, Zocor, Lipitor, etc.) significantly reduce CoQ10 levels in the body.

 

Q. For what health conditions is CoQ10 used?

A. CoQ10 is beneficial in treating and preventing CVD and conditions such as high blood pressure, atherosclerosis (hardening of the arteries), angina, and congestive heart failure (CHF). It’s been shown that heart attacks tend to occur when CoQ10 levels are low in the body. In addition, CoQ10 is beneficial for diabetes, immune dysfunction, cancer, periodontal disease, prostate cancer, and neurological disease.

 

Q. Why is CoQ10 especially important to heart health?

A. The heart is one of the most metabolically active tissues in the body. In the average person, the heart propels 2,000 gallons of blood through 65,000 miles of blood vessls by beating 100,000 times each day. Thus, it requires large amounts of uninterrupted energy. Heart cells have a greater number of mitochondria, and subsequently, more CoQ10 than any other type of cell. Each heart cell can have thousands of mitochondria to meet these energy demands.

 

Mitochondria are highly specialized structures within each cell and are often referred to as cell powerhouses. These tiny energy-produces produce 95% of the energy the body requires. The number of mitochondria in a cell depends on its function and energy needs. A cell’s ATP production is dependent on adequate amounts of CoQ10.

 

Heart disease patients are commonly CoQ10 deficient. Correcting such deficiencies often can produce amazing results. The presence of supplemental CoQ10 is a key to the heart’s optimum performance.

In people who have had a heart attack (myocardial infarction), CoQ10 assists in repairing the heart muscle and restoring heart function. This is due to increased ATP production.

 

Q. What studies support this fact?

A. A 1998 study found CoQ10 can provide rapid protective effects in patients with a heart attack if administered within three days of the onset of symptoms. The study focused on patients admitted to the hospital with an acute myocardial infarction (AMI) diagnosis. Seventy-three patients received CoQ10 (120 mg/d). The study’s control group consisted of 71 similarly matched patients with acute AMI. After treatment, angina pectoris (severe chest pain signifying interrupted blood flow to the heart), total arrhythmias (dangerously irregular heartbeats), and poor function in the left ventricle (the essential chamber of the heart) were significantly reduced in the CoQ10 group compared to the placebo group. Total deaths due to sudden cardiac failure and nonfatal heart attacks also were significantly reduced in the CoQ10 group compared with the placebo group.

 

In another study, CoQ10 was studied in 109 patients with high blood pressure (hypertension). The patients were given varying doses of supplemental CoQ10 with the goal of attaining a certain blood level (greater than 2.0 mcg/l). Most patients were on medications to treat hypertension. Half the patients were able to stop taking one to three antihypertensive drugs at an average of 4.4 months after starting CoQ10. Only 3% of patients required the addition of one antihypertensive drug. The 9.4% of patients who have echo cardiograms, performed both before and during treatment, experienced a highly significant improvement in heart wall thickness and function. This improvement was directly attributed to CoQ10 supplementation.

 

Congestive heart failure (CHF) is a debilitating disease that affects 5 million people in the U.s. It causes edema, difficult breathing, and impaired circulation. In another study, CoQ10 restored healthy heart function in CHF patients. Patients received 100 mg of CoQ10 or a placebo twice daily for 12 weeks. Before and after the treatment period, the investigators introduced a catheter into the right ventricle of patients’ hearts to determine the degree of CHF damage to the heart muscle. The patients’ heart muscles at rest and work improved significantly. The researchers concluded CHF patients would greatly benefit from adjunctive CoQ10 treatment.

 

Q. I’ve heard that CoQ10 can also help people who have neurological diseases. Is this true?

A. Yes, it is. CoQ10 has been studied for its ability to improve the health of individuals with amotrophic lateral sclerosis (ALS), Parkinson’s disease, and Huntington’s disease. A recently completed study sponsored by the National Institutes of Health showed that CoQ10 caused a slowing of the progression of Huntington’s disease, a devastating and degenerative disease that is always fatal. In fact, no other medication, drug, or nutritional supplemental has ever been shown to cause a decline in the progression of this terrible disease.

 

The study compared CoQ10 against remacemide (an investigational HD drug made by AstraZeneca Pharmaceuticals), in 347 HD patients who were in the early stages of the disease. Remacemide blocks glutamate, the neurotransmitter scientists think may cause the death of brain cells that occurs in Huntington’s disease. While remacemide had no effect on the progression of HD, CoQ10 showed a trend toward slowing the disease by an average of 15%. This meant the HD group taking CoQ10 was able to handle every day activities of life a little longer than the patients taking remacemide or a placebo. They also were able to focus their attention better, were less depressed, and less irritable. The 15% slowing of decline means that CoQ10 can result in about one more year of independence for HD patients. Needless to say, the gift of an additional year of health in the lives of HD patients is incredibly significant.

 

Because of these impressive results with HD, researchers are hopeful that the studies of CoQ10 in those with ALS and Parkinson’s disease will similarly have a positive effect on the symptoms and/or progression of these neurological disorders, too.

 

Q. Why is it crucial for a CoQ10 supplement to cross the blood-brain barrier?

A. The brains’ blood vessels are composed of cells with extremely tight junctions. These junctions form the blood-brain barrier, which restricts what can pass from the bloodstream into the brain. While this barrier protects the brain, it can be a significant obstacle to central nervous system therapy. To leave the bloodstream and reach the brain cells, a substance must pass through the tightly connected cells of the capillary walls. Only substances with unique solubilities or those with a transport system can cross the blood-brain barrier to a significant degree. As a result, crossing the blood-brain barrier presents a significant challenge to supporting neurological health.

 

While most CoQ10 supplements enter the bloodstream and increase blood serum levels, only special forms of CoQ10 have been shown to cross the blood-brain barrier. For CoQ10 to enter the mitochondria within the brain, CoQ10 must first cross the blood-brain barrier to produce significant neurosupportive clinical results.

 

Q. How can one supplement have applications for neurological diseases, heart health, and even the immune system?

A. Supplements often have more than one function, especially when it’s a substance like CoQ10, which is present in all parts of the body. All nucleated cells (most cells other than red blood cells) have mitochondria and all cells require energy to function. CoQ10 is vital to ATP production. Thus, CoQ10 has applications not only in neurological (neurons or nervous system cells) and cardiac health (myocardium or heart tissue), but also for the immune system.

 

Q. Are all CoQ10 supplements created equal? Doesn’t CoQ10 just have to get into the bloodstream to be effective?

A. There are some important distinctions among CoQ10 products, as they vary greatly in quality and absorbability. It’s crucial to find a CoQ10 product that’s:

 

1. Scientifically shown to absorb through the digestive tract, cross cellular membranes, and increase mitochondrial levels of CoQ10. Chewable forms of CoQ10 provide rapid bioavailability and absorption. Serum level determination of CoQ10 in the bloodstream is not necessarily the most important measure of efficacy. For a CoQ10 supplement to be fully effective, it must cross the cellular barrier and raise intracellular CoQ10 levels. A key indicator of effective CoQ10 supplementation is its presence in cell mitochondria.

 

2. The natural form of CoQ10. The natural process uses living organisms. CoQ10 also can be synthesized by a chemical process, which produces a distinctly different product that contains chemical compounds not found in the natural form.

 

3. Formulated with ingredients that provide the transport system CoQ10 needs to cross cellular membranes and the blood-brain barrier. Not all forms of CoQ10 have been scientifically proven to cross cell membranes and the blood-brain barrier. Some prestigious groups that have investigated this issue include researchers at Massachusetts General Hospital and Harvard Medical School.

 

4. Studied by respected organizations, with research published in peer-reviewed journals by reputable scientists.

 

Q. How much CoQ10 should I take?

A. Take 100 to 200 mg of CoQ10 daily, depending on your family history of heart disease and personal heart disease experience.

 

CoQ10’s safety has been evaluated. Dosages in studies have ranged from 100 mg to 1,200 mg per day. To date, no toxicities have been reported. Occasional mild stomach upset may occur. Taking CoQ10 with meals usually alleviates this rare effect.

 

Q. What are some other heart-friendly supplements?

A. CoQ10 is an excellent supplement for overall cardiovascular health, as in L-carnitine. L-carnitine is the naturally occurring form of carnitine that’s found in food and synthesized in the body. Much of the body’s L-carnitine is found in the heart and skeletal muscle, tissues that rely on fatty acid oxidation for most of their energy. Nearly 70% of the energy needed for heart function is derived from fatty acid breakdown. Proper L-carnitine supplementation transports fatty acids into cell mitochondria, where it’s burned for energy. L-carnitine is an excellent addition to CoQ10, especially for people with heart disease, and has been shown to improve many symptoms associated with CVD. In one study, people who had experienced one heart attack received either L-carnitine or placebo. The L-carnitine group had a statistically significant reduction in second heart attacks, and improved overall survival.

 

Q. What supplements support healthy blood pressure and cholesterol?

A. In addition to maintaining overall cardiovascular health, it’s also important to address your essential fats/lipids levels and healthy circulation/blood pressure. Fish oil supplements can significantly reduce blood pressure, cholesterol, and homocysteine levels. Choose a supplement that’s a rich source of EPA and DHA, omega-3 fatty acids naturally obtainable in fish oil. Find a product that’s been clinically studied and purified to ensure it contains the beneficial active constituents of the whole oil, while removing any dioxins, DDT, PCBs, or heavy metals, toxins present in some commercial fish oil preparations. An enteric-coated garlic product that provides a minimum of 5,000 mcg of beneficial allicin supports healthy blood pressure and circulation. And magnesium, niacin, vitamin E, folic acid, hawthorn extract, and L-cysteine provide overall nutritional support to the heart and vascular system.

 

Conclusion

CoQ10 is not the only answer to the complex issues of heart disease, neurological disease, or immune dysfunction; however, research indicates that it’s a bigger piece of the puzzle than physicians and scientists ever imagined. The more we study this naturally occurring compound, the more benefits we find.

The key to this supplement is the manufacturing quality. For safety and overall effectiveness, use a CoQ10 product that’s supported by product-specific research from reputable institutions. Choose tested products from a well-respected company to increase your potential to achieve and maintain heart and blood vessel health.

Supplementation with clinically studied products can have a major impact on your heart’s health and strength. However, no supplement replaces the need to eat a healthful diet low in refined foods (especially sugar), and saturated fats, and to exercise your most important muscle – your heart – on a regular basis.