Search Term: " Granules "
What Are The Health Benefits Of Coconut Sugar?
March 16, 2014 04:33 PM
Coconut sugar and its health benefits
Coconut sugar is extracted from young coconut tree flowers and provides the best natural organic sugar and a source of the best alternative to sugar cane based sweeteners and the best solution for people suffering from sugar related conditions such as blood sugar diabetes and heart diseases. Further, coconut sugar is known to reduce incidences of obesity and the bring down the levels of cholesterol in the blood.
Coconut sugar has the lowest glycemic sugar component index and is one of the best sources of vitamins and minerals that are crucial for the normal body functioning and systemic cycle. With the same features of the normal sugar such as texture and Granules, this is the best alternative to have around. The best part of this is that coconut sugar contains no artificial additives and has no artificial preservatives and this makes it the best source of healthy sugar with no whitening and bleaching.
Lecithin And Its Brain Boosting Properties
March 02, 2012 07:10 AM
Lecithin is a group of fatty substances, which occur in the tissues of plants and animals. It composed of fatty acids, choline, phosphoric acid, triglycerides, glycolipids, B vitamins, glycerol, and phospholipids. Liver produces this substance daily if you follow a complete nutritional diet. Lecithin is also inevitable for all cells in your body,protecting your cells from oxidation, and it is a major building block of cell membranes. It also supports the circulatory system of your body because it is a fat emulsifier too.
The first isolation of lecithin was done by a French pharmacist and chemist, Theodore Gobley in 1846 and he named phosphatidylcholine Lechithine in 1850. He isolated it originally from egg yolk. Today, lecithin can very easily be extracted mechanically or chemically from soybean, grape seed, and sunflower. However, in plants, the most common source of lecithin is soybean. This substance is used for medicinal purposes and as a food supplement. Sometimes, it is used as an emulsifier in cooking for preventing sticking.
Your body gets adequate amount of lecithin from your diet because it is naturally found in foods such as soybeans, egg yolk, peanuts, yeast, legumes, fish, wheat germ, grains, etc. It is also available in the market in the form of capsules, Granules, and powder. This is also used as a supplement for promoting weight loss. Besides, you can also take lecithin in the form of pill or mixed in health shakes.
Health benefits of lecithin
It is believed that lecithin is beneficial for solving a number of health problems. So it is effective for:
* Cell communication,
Brain Boosting Properties of Lecithin
The major brain chemical for improving memory is acetycholine and the deficiency of this chemical is the major cause of declining memory. This chemical can be derived from nutrient choline. Fish is a rich source of acetylcholine. It can also be obtained from eggs, nuts, peanuts, soy beans, liver, etc. Eating more egg is beneficial for enhancing your memory.
There are lots of studies has been conducted for finding the effectiveness of lecithin in improving the memory. As per the findings of experts, lecithin is highly effective for improving concentration, memory, and for preventing Alzheimer's disease and maniac depression (bipolar disorder). Lecithin helps to run your brain smoothly by improving insulation around the nerves. A major part of cell membranes consists of lecithin and it is essential for the proper functioning and growth of nerve. Organ meats and egg yolks are rich sources of lecithin but the usage of these products is very less due to the fear of cholesterol. Experts think that this is the major reason for the increase of concentration and memory problems.
If you use lecithin properly, you can improve your concentration, memory, mind and nerves.
Improve Immune System, Digestion, Muscle Recover, The Skin, And More with OptiZinc
May 31, 2011 03:45 PM
Zinc And Your Health.
OptiZinc is a patented zinc supplement in which the trace element zinc is bound to the essential amino acid methionine. It is especially formulated to guarantee absorption of zinc at a rate far superior to other zinc supplements. Hence, it is commercially touted to be the form of zinc best suited for people diagnosed with zinc deficiency. Decades-long studies have recorded noticeable effects on health.
Increases Immune Function
Zinc has long been tied to the immune system. For one, all white blood cells that contain Granules in their cytoplasm secrete zinc at certain immune responses. In addition, several other cells in the employ of the immune system utilize zinc signaling for cell-to-cell communication. OptiZinc increases availability of elemental zinc for use by immune cells and modulates immune function in the process.
Promotes Healthy Metabolism
Zinc is one of the trace elements that are pervasive at the cellular level. Proteins that belong to all enzyme classes necessitate the presence of zinc to activate their catalytic activities. The scientific community has long come to a conclusion that zinc is absolutely necessary for healthy metabolism, and thus the daily zinc needs of the body must be met to avoid impairment of physiological functions.
Aids Digestive Processes
OptiZinc is particularly good for the gastrointestinal tract. It contains up to 200 per cent of the recommended daily value for zinc to ensure absorption and aid digestion at the same time. Zinc ions are directly involved in the antimicrobial activities that take place in the intestines. Digestive enzymes that contain zinc are responsible for the breakdown of peptide bonds of proteins during digestion.
Accelerates Muscle Recovery
Supplementation of OptiZinc is likely to benefit people who engage in regular physical activities, especially athletes and bodybuilders. This formulation of zinc contains an equal ration of zinc to methionine, an essential amino acid necessitated in the biosynthesis of many other amino acids. OptiZinc speeds up the recovery of skeletal muscles after subjected to intense exercise.
Improves Skin Conditions
It is well established fact that a deficiency in zinc leads to higher incidence to acne. Severe cases even result in progressive hair loss and skin ulcer formation. These skin conditions are in fact a symptom of a metabolic disorder affecting the uptake of zinc, whether congenital or acquired. OptiZinc have been reported to alleviate zinc deficiency-induced skin problems and promote healthy-looking skin.
Scavenges Free Radicals
OptiZinc is a noted free radical scavenger. Its efficacy in preventing oxidative stress has been associated to the prevention of a diverse variety of illnesses, which include eye problems, prostate inflammation, and neurodegenerative diseases. This special formulation of zinc delivers the highest absorbable amounts of zinc into the systemic circulation to effectively prevent radical damage.
How to detoxify from heavy metal aluminum toxitity
November 09, 2010 06:04 PM
Although aluminum is not a heavy metal, it can be toxic if present in excessive amounts or small amounts if it is deposited in the brain. Many of the symptoms of aluminum toxicity are similar to those of Alzheimer’s disease and osteoporosis. Aluminum toxicity can often lead to colic, rickets, gastrointestinal disturbances, poor calcium metabolism, extreme nervousness, anemia, headaches, decreased liver and kidney function, forgetfulness, speech disturbances, memory loss, softening of the bones, and weak, aching muscles. Since aluminum is excreted through the kidneys, toxic amounts of aluminum can often impair kidney function.
When aluminum salts accumulate in the brain, seizures and reduced mental function can often result. In order to reach the brain, aluminum must pass the blood-brain barrier, which is an elaborate structure that filters the blood before it reaches the vital organ. Although elemental aluminum does not ordinarily pass through this barrier, certain aluminum compounds, such as aluminum fluoride, will. Many municipal water supplies are treated with aluminum sulfate and fluoride. These two chemicals readily combine with each other in the blood and are poorly excreted in the urine. The absorption of high levels of aluminum and silicon in the intestines can result in the formation of compounds that accumulate in the cerebral cortex and prevent nerve impulses from being carried to and from the brain in the proper manner. This situation can be aggravated by a chronic calcium deficiency.
People who have spent their career in aluminum smelting plants for long periods have been known to experience dizziness, impaired coordination, and a loss of balance and energy. When aluminum accumulates in the brain, the above symptoms are often caused. Perhaps the most alarming thing to note it that there is evidence to suggest that long-term accumulation of aluminum in the brain may contribute to the development of Alzheimer’s disease. It has been estimated that an ordinary person ingests about 3 and 10 milligrams of aluminum a day. Aluminum, being the most abundant metallic element in the earth’s crust, is primarily absorbed in the body through the digestive tract, but can also be absorbed through the lungs and skin. Additionally, aluminum can be absorbed by and accumulate in the body tissues. Since aluminum permeates our air, water, and soil, it can be found naturally in varying amounts in almost all food and water. Aluminum is also used to make cookware, cooking utensils, and foil, along with being present in many other everyday products including over-the-counter painkillers, anti-inflammatories, douche preparations, antacids, baking powder, food processing, antiperspirants, toothpaste, dental amalgams, bleached flour, grated cheese, table salt, beer, and municipal water supplies.
The following nutrients are very helpful when dealing with aluminum toxicity: apple pectin, calcium, magnesium, coenzyme A, garlic, kelp, lecithin capsules or Granules, l-glutathione, a multivitamin and mineral complex, SAMe, vitamin B complex, N-Acetyl Cysteine, and vitamin E. Additionally, the following herbs are great for blocking damage to the body from toxic heavy metals and radiation when taken regularly: burdock root, Echinacea, ginseng, ginkgo biloba, and fiber. Other recommendations to help prevent aluminum toxicity include maintaining a diet that is high in fiber and includes apple pectin; using only stainless steel, glass, or iron cookware, with stainless steel being the best; and being aware of the products that contain aluminum by reading labels and avoiding those that contain aluminum. Sulfur container foods like N-Acetyl Cysteine can help find up heavy metals and eliminate them from the body. If you suspect you have heavy metal toxicity, consult your health care provider immediately.
Beef Liver Is Nutritous For You
September 03, 2010 12:51 PM
Beef Liver Health Benefits
Beef liver is packed full of nutrients, including significant quantities of several B vitamins: B1 thiamin), B2 (riboflavin), B3 (niacin), B6 (pyridoxine), B12 (cobalamin) and folate. It also contains large amounts of Vitamin A - in fact the liver of the polar bear contains so much Vitamin A that it is toxic to humans and eating its liver can be fatal. Vitamin C is another vitamin, and beef liver also offers a number of useful minerals, such as phosphorus, iron, zinc and copper.
However, liver is available in a number of forms: raw, cooked or as desiccated raw beef liver Granules. The Argentineans often eat their beef liver raw or only slightly cooked, and they get the best deal as far as nutrition is concerned. That is because cooking destroys Vitamin C and thiamin and so, if you do not like eating raw liver, Argentinean Beef Liver Granules are likely the best form in which to take this very nutritious food source.
Beef Liver Supplements
Oil Skin Treatment
February 12, 2010 12:31 PM
Oily skin is the result of the sebaceous glands, which are the oil-secreting glands, produce more oil than is needed for proper lubrication of the skin. The excess oil is responsible for clogging pores and causing blemishes. Oily skin is most likely a result of heredity. However, it is known to be affected by factors such as diet, hormone levels, pregnancy, birth control pills, and the cosmetics that you use. Humidity and hot weather stimulate the sebaceous glands to produce more oil. However, it can occur at any age. A lot of people have skin that is oily only in certain areas and dry or normal in others. This condition is known as combination skin. Generally, the forehead, nose, chin, and upper back tend to be the areas that are more oily than other areas.
Oily skin does have some positive aspects. This type of skin is slow to develop age spots and discoloration, fine lines, and wrinkles. Often, it doesn’t freckle or turn red in the sun. It actually tans evenly and beautifully. On the negative side, oily skin is extremely prone to breakouts, even past adolescence. Oily skin also has a chronically shiny appearance, an oily or greasy feeling, and enlarged pores. The following nutrients are recommended for the prevention and maintenance of oily skin. The dosages recommended are for adults unless otherwise specified. For children between the ages of twelve and seventeen, the dosages should be reduced to three-quarters the recommended amount.
Flaxseed oil capsule or liquid in dosages of 1,000 mg daily or 1 tsp daily is helpful in supplying needed essential fatty acids. This nutrient is a good healer for most skin disorders. 25,000 IU of vitamin A for three months is necessary for healing and construction of new skin tissue. Vitamin B complex should be used as directed on the label as B vitamins are important for healthy skin tone. 1,000 to 1,500 mg of kelp should be taken daily. This nutrient is responsible for supplying balanced minerals that are needed for good skin tone.
Vitamin E should be taken in dosages of 200 IU daily or 400 IU every other day to protect against free radicals. 50 mg of zinc should be taken daily for tissue repair. This nutrient also enhances immune response. Grape seed extract should be taken as directed on the label, as it is a powerful antioxidant that protects skin cells. 500 mg of L-cysteine should be taken on an empty stomach, as it contains sulfur which is needed for healthy skin. 1 tsp of lecithin Granules should be taken three times daily before meals. This nutrient is needed for better absorption of the essential fatty acids. SOD should be taken as directed on the label. It acts as a free radical destroyer. Tretinoin should be used as prescribed by a physician. This nutrient acts as a gradual chemical peel, unclogs pores, and speeds up sloughing off of top layers of skin. It helps to expose new, fresh skin.
Additionally, the following herbs may be beneficial: aloe vera, burdock root, chamomile, horsetail, oat straw, thyme, lavender, lemongrass, licorice root, rosebuds, and witch hazel. If you have a oily skin, washing the affected area two or three times daily will help keep the skin oil free and reduce acne along with a healthy diet low in sugar and vitamin supplements.
April 15, 2009 01:20 PM
Thrombophlebitis is when inflammation occurs in the veins due to the formation of a blood clot in that vein. This problem usually occurs in the extremities, especially the legs. Thrombophlebitis can be considered superficial if it affects the subsutaneous vein, which is one of the veins near the skin’s surface.
In superficial thrombophlebitis, the affected vein can be felt and may be seen as a reddish line under the skin. Additionally, swelling, pain, and tenderness to touch can occur. If widespread vein involvement is included, the lymphatic vessels may become inflamed. Superficial thrombophlebitis is a relatively common disorder that can be brought about by trauma infection, standing for long periods of time, lack of exercise, and intravenous drug use. The risk of superficial thrombophlebitis can be increased by pregnancy, varicose veins, obesity, and smoking. Thrombophlebitis can also be associated with environmental sensitivities to allergies. This condition is usually diagnosed according to physical findings and a medical history that indicates an increased risk.
Deep thrombophlebitis (DVT) affects the intramuscular veins farther below the skin’s surface. DVT is a much more serious condition than superficial thrombophlebitis because the veins affected are larger and located deep within the musculature of the leg. These veins are responsible for the transport of 90 percent of the blood that flows back to the heart from the legs. Symptoms of DVT may include pain, warmth, swelling, and bluish discoloration of the skin of the affected limb. These symptoms are often accompanied by fever and chills. The pain is typically felt as a deep soreness that is worse when standing or walking and gets better with rest, especially with elevation of the leg. The veins directly under the skin may become dilated and more visible. Inflammation situated in a vein in the pelvis is referred to as pelvic vein thrombophlebitis.
The reason or reasons for the formation of the clots in the veins are often unknown. However, in most cases, clots are probably the result of a minor injury to the inside lining of a blood vessel. If the vessel lining receives a microscopic tear, clotting is initiated. Platelets clump together to protect the injured area, and a series of biochemical events is initiated that results in the transformation of fibrinogen, a circulating blood protein, into strands of insoluble fibrin, which are deposited to form a net that traps blood cells, plasma, and yet more platelets. This results in a blood clot. Other possible causes of the formation of DVT include abnormal clotting tendencies; poor circulation; certain types of cancer; and Behcet’s syndrome, which is a condition that affects small blood vessels that predispose an individual to the formation of clots. The following factors increase the risk of DVT: recent childbirth, surgery, trauma, the use of birth control pills; and prolonged bed rest.
The following nutrients are recommended for the prevention and treatment of thrombophlebitis: acetyl-l-carnitine, coenzyme Q10, flaxseed oil, garlic, l-cysteine, lecithin Granules, l-histidine, magnesium, MSM, Pycnogenol, vitamin C with bioflavonoids, vitamin E, zinc, and vitamin B complex. Additionally, the following herbs may be beneficial: alfalfa, pau d’arco, red raspberry, rosemary, yarrow, butcher’s broom, cayenne, ginger, plantain, witch hazel, skullcap, valerian root, ginkgo biloba, goldenseal, hawthorn, and olive leaf extract.
Natural vitamins are a great way to help prevent conditions such as these. If you suspect that you have thrombophlebitis, consult your doctor before trying to take the problem into your own hands. Natural vitamins such as the ones listed above can be found at your local or internet health food store.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Natural vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
March 27, 2009 01:56 PM
Menopause is the time at which a woman stops ovulating and menstruation ceases, which indicates the end of fertility. Menopause is not a disease, but rather a natural progression in life, similar to puberty. Many years before a woman stops ovulating, her ovaries will begin to slow their production of the hormones estrogen, progesterone, and testosterone. Estrogen and progesterone are often thought of as the reproductive hormones.
Although estrogen is essential in reproduction, it is also extremely important in other non-reproductive organs and systems in the body. Cells in the uterus, bladder, breasts, skin, bones, arteries, heart, liver, and brain all contain estrogen receptors. These organs need this hormone in order to stimulate these receptors for normal cell function. Estrogen is needed to keep the skin smooth and moist and the body’s internal thermostat working properly. Estrogen is also essential for proper bone formation. Even though estrogen levels drop sharply after menopause, they do not disappear entirely. Other organs take over for the ovaries, continuing to produce a less potent form of estrogen. These organs, known as endocrine glands, secrete some hormones from fatty tissue in order to maintain bodily functions.
Progesterone works along with estrogen, stimulating changes in the lining of the uterus to complete the preparation for a fertilized egg during the second half of the menstrual cycle. If no egg is fertilized, the uterine lining is broken down and expelled, allowing the cycle to being again. Progesterone also has effects beyond the reproductive system, as it calms the brain and also affects other aspects of nervous system function. Testosterone is most important for both men and women, with women producing about 80 percent less than men do. However, it is the driving force for maintaining a healthy life and proper functioning organs.
The period when a woman’s body is preparing for menopause is known as perimenopause. For the majority of women, hormone production beings to slow down then they reach their thirties, continuing to diminish with age. Many women will experience few if any symptoms at this time, but others may suffer from anxiety, dry skin, fatigue, feelings of bloating, headaches, heart palpitations, hot flashes, insomnia, irritability, decreased interest in their significant other, loss of concentration, mood swings, night sweats, reduced stamina, urinary incontinence, uterine dryness and itching, weight gain, cold hands and feet, joint pain, hair loss, and/or skin changes.
Menopause occurs when a woman stops menstruating altogether. At this point, most of the acute problems a woman may have experienced are actually over and a new balance between all hormones should be established. However, women become increasingly vulnerable to other, potentially serious health problems at this time. Over the long term, the diminished supply of estrogen increased the likelihood of cardiovascular disease, osteoporosis, and uterine atrophy. Osteoporosis especially is a major problem for women after menopause, with an estimated 80 percent of the hip fractures that occur in the United States every year being due to osteoporosis.
A proper diet, nutritional supplements, and exercise can help to minimize or eliminate most of the unpleasant side effects of menopause. The following nutrients are recommended for dealing with this stage of life: beta-1, cerasomal, coenzyme Q10, DHEA, essential fatty acids, lecithin Granules, a multi-enzyme complex, soy protein, vitamin B complex, vitamin D3, vitamin E, boron, calcium, magnesium, quercetin, silica, zinc, l-arginine, multiglandular complex, a multivitamin and mineral complex, vitamin C, aloe vera gel, slippery elm, damiana, amaranth, chickweed, dandelion greens, nettle, seaweed, watercress, anise, black cohosh, fennel, licorice, raspberry, sage, unicorn root, wild yam root, hops, valerian root, gotu kola, red clover, dong quai, St. John’s wort, and Siberian ginseng.
All these above listed vitamins and herbs are available in capsule, tablet, or powder forms. When looking for natural alternatives to help replace estrogen naturally, look to your local or internet health food store for name brand products that can help restore an imbalance over time.
March 23, 2009 01:56 PM
Our memory is as natural to us as breathing. An ability we all have, but don’t often think of, it doesn’t seem to cross our mind until we perceive that we are losing the ability. Memory lapses are an annoyance in themselves, but the anxiety that often comes along with them seems to be even worse. We often wonder if our memory problems are a symptom of some other problem like midlife depression, arteriosclerosis, or even Alzheimer’s disease. Although Alzheimer’s disease is a fairly common disorder among older people, one must realize that most memory lapses have nothing to do with Alzheimer’s disease.
Generally, it is believed that increasing age brings about an increased likelihood of developing memory loss. The mildest form of this illness is called age-associated memory impairment. This is characterized by one’s perception of his or her own memory loss and it is estimated that it is experienced by 40 percent of Americans over the age of sixty-five. Not all memory loss is attributable to aging, as occasional memory lapses are a natural normal part of life at almost any age, and are not likely to precede serious memory loss. With a proper diet, nutrition, and memory use, the memory should remain sharp and active well into one’s nineties or beyond.
One big reason why people suffer from memory loss is an insufficient supply of necessary nutrients to the brain. The life of the body is in the blood, as it literally feeds and nourishes every cell within our bodies. Only certain substances are allowed to pass from the bloodstream into the brain, thanks to the protective envelope that is known as the blood-brain barrier. If the blood is thick with cholesterol and triglycerides, the amount of nutrient-rich blood that can pass through the blood-brain barrier decreases. This can result in the brain becoming malnourished over time.
The functioning of the brain also depends upon substances that are referred to as neurotransmitters, which are brain chemicals that act as electrical switches in the brain and are responsible for all the functions of the body. If the brain does not have an adequate supply of neurotransmitters, or the nutrients to make them, it starts to develop something similar to a power failure or a short circuit. If you are trying to recall as specific fact or piece of information and your mind goes blank, it is likely that the above “short circuit” has occurred.
There are many other factors that are involved in the deterioration of the memory. One of the most important is exposure to free radicals, which can cause huge amounts of damage if the memory is unchecked. Alcoholics and drug addicts often suffer a great deal of memory loss, with alcoholics being notorious for huge memory gaps that occur even though they are conscious. Allergies, candidiasis, stress, thyroid disorders, and poor circulation to the brain can also contribute to memory loss, while hypoglycemia can play a role in memory loss as well, as the brain requires that the level of glucose in the blood fall within a specific narrow range. Wide swings in blood sugar levels affect brain function and memory.
The following nutrients are beneficial in dealing with and preventing memory loss: acetylcholine, boron, DMAE, garlic, huperzine A, lecithin Granules, manganese, multivitamin and mineral complex, omega-3 fatty acid complex, phosphatidyl choline, phosphatidyl serine, SOD, vitamin A, vitamin B complex, vitamin B3, vitamin C, vitamin E, zinc, acetyl-l-carnitine, l-glutamine, l-tyrosine, coenzyme Q10, DHEA, DMG, melatonin, NADH, pregnenolone, RNA and DNA, Brahmi, ginkgo biloba, anise, blue cohosh, ginseng, gotu kola, and rosemary.
All of the above mentioned as well as formulas tailored to help improve memory can be found in capsule, table, or power forms. Remember, only look to name brands such as Solaray, Source Naturals and Natures Plus for quality products. Memory vitamins and herbs can be found at your local or internet health food store.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Vitamins and herbs are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
Fight Histamine With Quercetin
February 11, 2008 03:48 PM
Quercetin is one of the more powerful of the body’s antioxidants, and it can also be used to reduce the rate of histamine release by the body normally initiated by contact with an allergenic substance (for which your immune system has designed an antigen). We shall examine the biochemical mechanism which this is achieved, but first let’s have a closer look at quercetin and what it actually is.
Quercetin is what is known as a phytochemical, which is simply the scientific name for a chemical that is naturally produced by plants. Other phytochemicals include vitamin C and omega 3 fatty acids, so the term is very broad ranging for any substance that is produced by plants. It is commonly known as a flavanol, one of a family of compounds known as flavonoids that give color to plants.
It is a very active flavonoid, with very powerful antioxidant properties, in addition to acting as an anti-histamine and anti-inflammatory. Histamine is an amine released as part of the body’s immune response to allergenics, and quercetin inhibits its manufacture and release. This amine is an irritant and can itself cause inflammation and the other symptoms associated with allergies such as runny and itchy eyes, a stuffy nose, sneezing and itchy spots. Quercetin can be used to alleviate these symptoms by blocking the manufacture in the body of the histamine that causes them.
It demonstrates other anti-inflammatory properties such as alleviating the symptoms of arthritis, and also helps to destroy free radicals in the body through its strong antioxidant properties, but before we discuss how it does this we shall have a closer look at the mechanisms used in its effect in inhibiting histamine.
Calmodulin is a protein that is used to transport calcium ions, Ca++, across the membranes of certain cells in the body, and by doing so it helps to mediate a number of biochemical processes within the body, among them the immune response and inflammation. It should not be thought these are always unwelcome responses: on the contrary, they are the body’s way of reacting to foreign bodies and preventing more serious conditions from developing.
However, there are instances where the body can become sensitized to certain substances and overreact to their presence leading to conditions such as hay fever or, considerably more serious, asthma. These are just two of the undesirable manifestations of the human immune system that we would be better without. What quercetin does is to prevent calmodulin from properly binding to certain enzymic proteins and so suppress the effect of these proteins. Among these are the enzymes that control the secretion of histamine from mast cells.
Mast cells are found mainly in areas prone to injury and at the interface between internal tissues and outside world, such as the nose, mouth, lungs, eyes, blood vessels and feet. They contain Granules rich in histamine that degranulate and released the histamine when the immune system detects foreign bodies such as pollen grains and dust mites, especially when the body has created antigens against them.
Quercetin suppresses the release of histamine from the Granules in the mast cells by preventing the degranulation. The release of the histamine is not completely halted, but its effects are reduced and quercetin is used in the treatment of asthma where it is believed to help reduce the symptoms by reducing histamine-induced swelling in the airways.
A similar application of this flavonoid is in reducing the inflammatory response to arthritis, the main cause of the swelling of this painful condition. Your skin can also be affected by inflammation that is partially controllable by quercetin. Collagen and fibronectin biosynthesis is increased that help to maintain not only healthy joints, but also to speed up the healing of wounds and repair damaged nerves. It is also believed that quercetin can hold back the effects of aging on the skin, and slow down the formation of wrinkles.
There are other applications of this versatile flavanol, including its effect on acute prostatitis where it reduces oxidative stress and the accompanying inflammation of the prostate gland. In fact, it is believed to have positive effect on many conditions caused by free radical oxidation and excessive reaction by the immune system causing inflammation. Apart from the allergies and arthritis previously referred to, quercetin is believed to have been effectively used in the treatment of gout, macular degeneration and heart disease, and it can also help to prevent the oxidation of low density lipoproteins (LDL) responsible for transporting cholesterol to where it is needed to repair major blood vessels.
When these lipoproteins become oxidized by free radicals then the cholesterol associated with them tends to be excessively deposited in the arteries it is meant to be repairing, and lead to atherosclerosis. This condition can lead to heart failure or to strokes if the blood vessels are in the brain.
Studies have indicated that the flavonoid might help to prevent certain cancers by preventing the nutrition of some types of cancerous cells, effectively killing them. Due to its phytoestrogen properties, quercetin can be used to bind to the sites in cancerous cells that are receptive to estrogen and so prevent their growth. Many types of cancerous cells need estrogen for their growth and proliferation, and phytoestrogens mimic the effect of this hormone. However, these are laboratory studies, and more work is required.
More certain is the effect of quercetin on heart disease due largely to the aforementioned control of cholesterol deposition in your arteries, but also through its ability to strengthen the capillaries. However, when all things are considered, it is in the properties of this non-allergenic bioflavonoid to fight histamine release that it finds it’s most popular and effective use.
So what is the best way to take quercetin? Like most bioflavonoids, it is available naturally in the majority of plant foods. Particularly rich sources are broccoli, red onions, red apple skins, black tea, red wine, red and purple berries and almost all dark green leafy vegetables.
However, the name of the game these days is to take measured doses, and while you should continue to eat these foods, you can also receive controlled doses by use of supplements. From 200 to 500 milligrams thrice daily is a good average dose, depending on the severity of your immune reaction or allergy. Bromelain is believed to improve its absorption in the gut, and quercetin is frequently provided with bromelain, which itself is also a good treatment for allergies and excessive response of your immune system to irritation.
Bromelain is an enzyme, generally extracted from pineapple, and treatments higher than the above doses of quercetin with or without bromelain are available online, although like any natural remedy you should inform your own physician of the dosage you are taking.
There is no better non-allergenic bioflavonoid to fight histamine and its potentially unpleasant effects on your body than quercetin.
Best Hyaluronic Acid w/Chondroitin Sulfate - Benefits of...
July 27, 2005 12:28 PM
• Supports Healthy Joint Structure and Function*
Components of BioCell Collagen II including collagen type II, chondroitin sulfate and hyaluronic acid (HA) can enhance proteoglycans in the joint matrix, thereby providing support for healthy joint function and maintaining joint shock absorption and cushioning.
Chondroitin has been well studied for its effects on joint health. In a 1996 controlled, double-blind trial published in the Journal of Rheumatology, 146 volunteers consumed chondroitin sulfate daily for 6 months. Changes in joint function were measured according to several clinical parameters and carefully analyzed. After the first month, significant improvements were noted and maintained for three months after the subjects stopped taking the chondroitin sulfate.1 In an earlier double-blind study subjects taking chondroitin sulfate had improvements in joint function after three months of use, as determined by both objective and subjective measurements.2 In both studies, the benefits lasted for weeks after subjects stopped taking chondroitin sulfate.
In another controlled study, 192 subjects took chondroitin sulfate or a placebo daily for one year. At the end of the trial, chondroitin sulfate maintained healthy joint cartilage thickness, while those on placebo had decreased cartilage. Improvements in joint function also occurred. The researchers reported that chondroitin exerted a clear chondroprotective effect.3
COLLAGEN TYPE II
A number of studies have also been conducted on the administration of collagen type II to individuals that have various joint issues. Much of this research has been conducted on animal models of joint conditions while there are also studies showing the effectiveness of oral collagen type II preparations in humans for maintenance of healthy joints.
A randomized controlled trial conducted on 60 patients with joint health issues in 1993 found that oral administration of chicken collagen type II for 3 months led to a significant decrease in swollen and tender joints in this group, as compared to no measurable improvement in the placebo group. There were also no side effects seen with the treatment.4 A second multicenter, double-blind, placebo-controlled trial in 274 individuals with joint issues was published in 1998. The participants were given collagen type II orally for 24 weeks. Positive effects of the treatment were noted while no adverse effects were seen.5
A paper published in 2000 reviewed the literature to assess the role of hydrolyzed collagen in joint and bone health. It was found that hydrolyzed collagen when administered orally was able to support joint health in most of the trials reviewed while the author concluded that, “Its high level of safety makes it attractive as an agent for long-term use.”6
HYALURONIC ACID (HA)
Most of the literature on hyaluronic acid and joint health deals with its intra-articular use, or injections of HA directly into the joints. In this realm, there is good evidence for the effects of HA on joint function.
A study was conducted with injectable HA in individuals with TMJ (temporomandibular joint) conditions. Participants received two injections, each one week apart, or placebo injections with saline. In the HA group, the researchers found decreased clicking sounds and increased function of the joint at 1 month (90% of patients showed improvement) and 6 months (63%) of follow-up, compared to about 26% of the placebo group showing improvement at 6 months.7
A pair of researchers also conducted a literature review of the trials using HA for improving joint health that was published in 2005. Their findings indicate a positive role for HA in modifying the structure of the joint and slowing progressive deterioration of joint function and mobility.8 Hyaluronic acid seems to have a natural affinity for joint tissue, and is therefore able to help support healthy joint structure and function.
• SuSupports Healthy Joint Structure and Function*
Hyaluronic Acid and Collagen are both vital components of skin tissue. Both compounds are known to decline with aging. Collagen is a vital structural component of the skin. It is also one of the most important substances required for proper skin barrier function and health. Collagen, as a major component of the connective tissue, provides structural support, increasing elasticity and tone of the skin.
In 1994, researchers performed comparative measurements of hyaluronic acid levels in the skin of young and elderly individuals. The researchers had hypothesized that a major reason for the aged appearance of skin in the elderly is a reduction of hyaluronic acid levels. What they found using their methods is that there is a progressive reduction in the number of hyaluronic acid Granules in human skin with age, until a complete absence of these Granules was seen in individuals 60 years or older. These variations in HA levels with age could, according to the researchers, account for the decreased turgidity, wrinkled appearance and altered elasticity of skin tissue.9 Further research was needed to determine the effect of exogenously administered HA on the suppleness of human skin.
In a laboratory study conducted in 1998, researchers analyzed the effects of HA given to live human skin cells. Whereas the cells on their own had a low rate of renewal, hyaluronic acid added to the cells resulted in increased proliferation of skin cells in the collagen matrix. This showed that supplementing skin cells with HA caused a significant increase in the ability of cells to go through the cell cycle.10 One of the major benefits of this may be hyaluronic acid’s ability to continually renew skin tissue to help maintain a youthful appearance of the skin.
Suggested Adult Use: Take 2 capsules daily, or as directed by a health care practitioner. Take with 8-10 ounces of water, with or without food.
1. Morreale P, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol (1996) 23:1385-91.
2. Mazières B, et al. Chondroitin sulfate for the treatment of coxarthrosis and gonarthrosis. A prospective, multicenter, placebo-controlled, double blind trial with five months follow up. Rev. Rhum. Mal. Ostèoartic. 1992;59(7-8):466-472.
3. Pipitone V, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Current Therapeutic Research 1992 52(4):608-38.
4. Trentham DE, et al. Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 1993 Sep 24; 261(5129) 1727-30.
5. Barnett ML, et al. Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 1998 Feb; 41(2): 290-7.
6. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000 Oct;30(2):87-99.
7. Hepguler S, et al. The efficacy of intra-articular sodium hyaluronate in patients with reducing displaced disc of the temporomandibular joint. J Oral Rehab. 2002; 29: 80-86.
8. Goldberg VM, Buckwalter JA. Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity. Osteoarthritis Cartilage. 2005 Mar;13(3):216-24.
9. Ghersetich I, et al. Hyaluronic acid in cutaneous intrinsic aging. Int J Dermatol. 1994 Feb; 33(2): 119-22.
10. Greco RM, et al. Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix. J Cell Physiol. 1998 Dec; 177(3): 465-73.
Quercetin and Bromelain - for better health.
July 04, 2005 10:28 AM
Down-regulates the Body’s Response to Environmental Challenges Quercetin is a member of the flavonoid family, a diverse group of low molecular-weight compounds found throughout the plant kingdom. Flavonoids exhibit numerous biological activities, many of which are directly beneficial to human health. Quercetin, which belongs to the “flavonol” subgroup, is one of the most versatile and important flavonoids. Quercetin has a broad range of activity, much of which stems from its interaction with calmodulin, a calcium-regulatory protein.1 Calmodulin transports calcium ions across cellular membranes, initiating numerous cellular processes. Quercetin appears to act as a calmodulin antagonist.1 Through this mechanism, quercetin functions at the cell-membrane level with a membrane-stabilizing action.2 Quercetin inhibits calmodulin-dependent enzymes present at cell membranes such as ATPases and phospholipase, thereby influencing membrane permeability.3 Quercetin affects other calmodulin-dependent enzymes that control various cellular functions, including the secretion of histamine from mast cells.4 A number of investigations have corroborated quercetin’s ability to reduce histamine secretion from mast cells in various tissues, and also from basophils.5,6,7,8,9,10
Quercetin modifies the body’s response to antigenic substances.* Suppression of histamine secretion from mast cells is one of quercetin’s most clinically important effects. Quercetin acts on ATPase at the membranes of histamine-containing Granules in mast cells.3 Mast-cell degranulation and subsequent release of histamine into the bloodstream is an integral part of the body’s response to environmental challenges.
Quercetin’s enzyme-inhibiting action extends to enzymes such as phospholipase, which catalyzes the release of arachidonic acid from phospholipids stored in cell membranes.4,10 Arachidonic acid serves as the key substrate for substances such as thromboxanes, inflammatory prostaglandins and leukotrienes. In addition, quercetin inhibits the enzymes cyclooxygenase and lipoxygenase, which catalyze the conversion of arachidonic acid into its metabolites.4,10,11,12 Reducing levels of these metabolites, as well as histamine levels, is beneficial in maintaining the normal comfort level of body tissues and structures.
Quercetin has also been shown to limit the function of adhesion molecules on endothelial cells.13 Adhesion molecules are involved in physiologic processes that influence tissue comfort.13
Bromelain is a complex substance derived from the pineapple stem largely composed of proteolytic (protein-digesting) enzymes. Bromelain acts by a variety of mechanisms to help maintain tissues in a normal state of comfort.14,15 Several investigators, including Taussig16 and Ako, et. al.,17 have presented evidence that bromelain is a fibrinolytic agent, i.e., it induces the breakdown of fibrin, a plasma protein that blocks tissue drainage. The generally accepted mechanisms involve direct proteolysis of fibrin by bromelain and activation of plasmin, a serum protease.16 Plasmin acts on fibrinogen (the precursor to fibrin), forming peptides which stimulate PGE1, a prostaglandin that helps maintain tissue comfort.16
Helps Maintain Health of Blood Vessels by Modifying Oxidation of LDL Cholesterol* — Quercetin’s Antioxidant Action Quercetin is a versatile and effective antioxidant that scavenges a variety of free-radicals such as hydroxyl and lipid peroxy radicals.18 Quercetin also chelates ions of transition metals such as iron, which can initiate formation of oxygen free radicals.18 LDL cholesterol is vulnerable to oxidation by lipid peroxides. Oxidized LDL is absorbed by macrophages and arterial endothelial cells, leading to the formation of “foam cells,” and eventually plaque deposits, in arterial walls. Quercetin has been shown to protect LDL from oxidation, both by lipid peroxides and transition metal ions.19
Quercetin inhibits blood platelet aggregation (clumping), by potentiating PGI2, an anti-aggregatory prostaglandin, and by raising platelet cyclic AMP levels.20 Human studies have revealed that bromelain also reduces platelet aggregation.21 These properties qualify both quercetin and bromelain as valuable dietary ingredients for maintaining cardiovascular health.*
In addition to the actions described above that support the effects of quercetin, bromelain may also assist the absorption of quercetin in the G.I. tract. (Quercetin is generally believed to be poorly absorbed, although a recent study by Hollman et. al.,22 which concluded that humans do in fact absorb appreciable amounts of quercetin, contradicts this assumption.) Studies have shown that bromelain enhances absorption of antibiotics, presumably by increasing permeability of the gut wall.23, 24 Given that quercetin is a low molecular-weight compound, it is plausible that simultaneously ingested bromelain likewise enhances quercetin absorption.
Acupuncture nutrient Connection
June 12, 2005 05:53 PM
Acupuncture nutrient Connection by Robert Gluck Energy Times, November 1, 1998
The theory behind the practice of acupuncture confounds western science. This therapy, originating in Asia, is based on the concept that currents of energy called meridians flow through your body. However, no one has ever been able to conclusively demonstrate the existence of these meridians.
Despite the evasiveness of these energy streams, Traditional Chinese Medicine (TCM) holds that alterations in these energy flows can disrupt health and cause pain. Consequently, an acupuncturist punctures your skin with specialized needles to redirect the body's vital energy.
Despite the fact that western scientists have not been able to find satisfactory evidence of the existence of these energetic meridians, studies show that acupuncture works and is especially effective at relieving pain. This therapy has been used to alleviate a variety of conditions including chronic pain, nausea and even mental illness. In addition, some practitioners apply it to those trying to shake off the chains of drug addiction. (More recently, many practitioners now also successfully use acupuncture to relieve physical problems in animals.)
Of course, no matter what your perspective on this therapy, acupuncture's no panacea. While you might use acupuncture to relieve the discomforts of chemotherapy, you wouldn't use this technique as your primary weapon against a dangerous disease like cancer. Still, this reliable therapy occupies a welcome spot as an adjunct to many mainstream therapies. Consequently, many mainstream practitioners accept the validity of using acupuncture and many managed care companies reimburse this therapy. Some HMOs even keep a list of approved acupuncturists that they make available to enrollees.
Acupuncture East and West
The practice of acupuncture dates back at least 2200 years ago in Asia. Only during the last forty years has it become well-known and widely available in the United States. Today, 29 accredited acupuncture schools train practitioners in North America. In addition, traditional healers in Belize (south of Mexico) have been found to use a form of acupuncture derived from traditional Mayan medicine.
Is the use of acupuncture by Mayan shamans coincidence? Or further evidence that acupuncture meridians really exist? No one knows for sure, although some experts believe the Mayan use of this therapy supports the notion that the original ancestors of the Mayans migrated from Asia.
Acupuncturists insert needles into the body to relieve pain or enhance bodily functions. TCM holds that acupuncture, and the manipulation of these tiny needles, moves and manipulates qi (pronounced chee), the body's energy force.
"Acupuncture is a method of balancing the body's energy," says Carol Alexander, an acupuncturist at the North Jersey Health and Pain Relief Center in Hackettstown, New Jersey. "Disease occurs because of an imbalance...Insertion of the acupuncture needles into meridians will bring about the balance of qi." Alexander has practiced acupuncture for 10 years and studied at the Tri-State School of Traditional Acupuncture in Stanford Connecticut.
Alexander says patients sometimes suffer a blockage of qi or display too much or too little qi. The manipulation and placement of the acupuncture needles vary according to the need for adjusting meridian energy flow.
Acupuncture can be used to prevent disease and, if disease is already rampant, it can be used to help the body correct the problem.
In conjunction with her use of acupuncture needles, Alexander rarely prescribes single herbs but uses combinations of whole herbs that are very specific for different diseases and disease patterns. "Certain herbs, such as ginseng, are very prized in Chinese medicine," Alexander notes.
"Astragalus is an herb used in China and around the world to tonify the qi and increase qi energy as well as stimulate the immune system."
Alexander uses licorice root for assisting digestion and for helping women with menopausal discomforts. On the other hand, she recommends whole food concentrates like bee pollen Granules for enhancing the immune system, peppermint for treating gastro-intestinal problems plus fiber supplements as well as the antioxidant/antihistamine quercetin, coenzyme Q10 and melatonin.
"In terms of classes of nutrients, I use a lot of whole food concentrates: the green concentrates like barley greens, wheat grass powder, spirulina and blue-green algae," Alexander says. "These are high in minerals, antioxidants, nutrients and fatty acids. I also use some soy products because the isoflavone concentrates are very much anti-cancer."
The Fine Points of Acupuncture
Acupuncture needles are very fine, as thin as hairs. They are available in a variety of diameters and lengths. When an acupuncturist inserts these needles, the sensation is that of mild pinpricks. (The needles enter the body at depths of only 1/8th inch to two inches.) In many cases people experience mild pleasure during needle manipulation.
"From a Western point of view it's important to explain that there is a distinct function of acupuncture treatment and that is to increase circulation," Alexander says. "We do stimulate nerves and we know that with the stimulation of nerves many neurochemicals and neurotransmitters are released. They move through the nerves and find receptor sights, some in the brain, some in other parts of the body."
By stimulating nerves, acupuncturists can calm inflammation and deaden pain. These effects are believed to be linked to the release of endorphins and dinorphins, powerful painkillers and anti-inflammatories that the body produces for itself. Most acupuncturists use this therapy as part of an overall, multi-faceted treatment plan.
"Qi is what makes you different from a sack of chemicals," points out David Molony, an acupuncturist at the Lehigh Valley Acupuncture Center in Catasaqua, Pennsylvania who studied at the Nanjing Traditional Medicine Hospital in China and has lectured at Cornell University.
What You Need
"You can manipulate qi with acupuncture, herbs and diet. Because people's bodies work differently, there are different approaches. When you ask the question what nutrients and herbs are effective at enhancing acupuncture, it depends on what the person needs, according to an Oriental Medicine diagnosis."
An Oriental Medical examination, Molony says, begins with a long list of health questions designed to reveal factors that contribute to disease. A practitioner measures your pulse in several different places along your arm, inspects your tongue, may press on your stomach, sniff your general odor and closely examine your nails and skin for signs of problems.
"You take in everything you can," adds Molony, a board member of the Acupuncture Society of Pennsylvania and former board member of the American Association of Acupuncture and Oriental Medicine. "This gives you clues that you need in order to make your diagnosis."
Acupuncturists use nutrients and herbs that complement the treatment, as well as dietary and lifestyle counseling. Some acupuncturists don't specialize in herbal remedies, so these practitioners might go to a specialist like David Winston for advice. Winston, an herb expert skilled in Cherokee, Chinese and Western eclectic herbal medicine, works as an instructor, lecturer and consultant.
"In China, acupuncture is considered a complementary therapy; you generally don't go for treatment and get purely acupuncture," says Winston who is working on a book about saw palmetto. "Herbal medicine, diet and qi gong are important therapies in their own right and acupuncture is one of those therapies. Qi gong is a form of martial arts that focuses on unique breathing and visualization methods. Qi is not exactly energy, it's energy in movement; it's what makes the blood move."
Acupuncture is used to open blockages that sometimes build up in what TCM practitioners characterize as excessive heat or cold. These hot and cold spots do not always literally refer to the temperature of the body but are meant to depict changes in the character of the body's vital energy.
Chinese acupuncturists don't necessarily treat diseases, but target clusters of physical discomforts. Winston says, "Herbal formulas change depending on the 'symptom pictures.' Somebody could have acute appendicitis but the symptom picture could vary. Usually Chinese acupuncturists use herbs like isatis (a very cold, drying herb that's a powerful anti-bacterial agent) and coptis (a powerful anti-bacterial herb)."
Americans often visit acupuncturists complaining of back pain or some type of musculoskeletal problem-a wrenched knee, a ligament that hasn't healed properly or perhaps a torn rotator cuff. "If the injury is hot to the touch, it's red, it's inflammatory-that's a condition where there's excessive heat and in that condition the acupuncturist would give herbs that are cooling and anti-inflammatory such as the root of large leaf gentian."
Pain that Moves
If someone suffers pain that moves, pain that is sometimes exacerbated by damp or humid conditions, acupuncturists often prescribe clematis root, a wild variety of the garden plant that is an anti-spasmodic, or acanthopanax, a relative of Siberian ginseng used for damp pain.
"If there's pain with excessive dampness," Winston says, "acupuncturists might use duhuo, a drying herb that opens the meridians."
Molony agrees with Winston that when it comes to choosing herbs to enhance acupuncture, accurate analysis of the root cause of the health problem is paramount to making the right decisions. For example, if a person is qi deficient and her tongue is thickly coated, she may not be processing her energy properly. Phlegm builds up, decreasing energy. "What you want to do is give them herbs that move phlegm, like citrus peel, and combine that with acupuncture points that move phlegm also," Molony says.
For stimulating metabolism, Molony uses lactoferin-processed colostrum from cows. He uses ginseng and atractylodes as qi tonics and he adds herbs like magnolia bark or atractylodes alba.
He believes antioxidants are helpful too, as preventive medicines, including vitamins C and E. These valuable nutrients disarm the harm that reactive molecules can wreak within the body.
So how important are herbs and nutrition to enhance acupuncture's effectiveness? Acupuncturists seem to agree that healthy doses of antioxidants (such as vitamins C and E plus antioxidants from grapeseed extract) as well as specialized herbs, turn this therapy into a highly effective healing tool. Those wanting to benefit from this penetrating technique should stock up on nutrients. Then sit back, relax, kick off your shoes and let the acupuncturist do her stuff.
Important Information for Allergy Sufferers
May 13, 2005 09:52 AM
Important Information for Allergy SufferersRichard Conant, L.Ac. C.N.
Imagine you are one among millions who greet each spring with worry about the flood of pollen that fills the air this time of year. When the pollen season arrives, as it inevitably does, you find yourself with two choices. You can either take over-the-counter antihistamines and put up with unpleasant side-effects, or endure the sneezing, runny nose, itchy, watery eyes and other discomforts of hay fever.
If there was a natural ingredient, a nutritional substance found throughout nature in many foods and plants, that could offer an alternative, would you not be interested?
Quercetin, one among hundreds of flavonoids found throughout the plant kingdom, is this ingredient. Quercetin has been researched in numerous pharmacological studies. The results of this work strongly suggest that quercetin helps to stabilize the fundamental process in the body which causes an allergic reaction. Quercetin, as shown in test-tube ("in vitro") studies, prevents the release of histamine from "mast cells," immune cells that stand guard in the tissues which meet the outside environment—the nasal passages, the lungs, the digestive tract and skin. While this has yet to be confirmed by human clinical trials, in the picture that emerges from the research so far, quercetin looks like a rescue nutrient for allergy sufferers.
Reports from Quercetin Users
I have seen numerous reports from individuals who have indeed achieved significant reductions in allergic sensitivity by using quercetin. And this includes food allergies as well as environmental allergies. Anecdotal stories like these carry little weight among scientists, because they do not provide evidence that the observed result will be repeated in other cases. Only placebo-controlled, double-blind studies can produce this kind of scientific proof. Yet, when anectodal evidence (this includes physician "case reports") correlates with the results of pharmacological research such as we have on quercetin, I believe it should be taken seriously. And quercetin is a nutrient that works effectively when taken as a dietary supplement.
For example, one gentleman writes that his wife, who is allergic to pollen and dust, is now "sneeze-free" after using quercetin for three years. A Pennsylvania woman writes that her husband, also a long time allergy sufferer, "seems to be nearly allergy free" after one month of use. Another man says that "quercetin has literally changed my life." These are not isolated cases; a respected nutritionist who specializes in allergies and environmental problems has seen many similar outcomes with a quercetin. Clearly something significant is going on with respect to quercetin as a nutritional approach for overcoming allergies.
Bear in mind, though, that quercetin does not function like an antihistamine medication; it is not a quick fix. As a nutrient that helps to normalize body functions naturally, quercetin needs time to work, and should be taken for at least two or three weeks to achieve these results.
Exerting a broad range of biological effects, quercetin is perhaps the most active and versatile flavonoid. In test-tube studies, quercetin acts directly on the mast cell in a way that quiets the allergic response.
An allergic reaction occurs when IgE antibodies, positioned on the mast cell surface, come in contact with a potential allergy-causing substance like pollen. The mast cell is then signaled to release histamine from storage Granules located inside the cell, through a process called "degranulation." The histamine circulates throughout the body, causing the runny nose, itching and other discomforts associated with allergies.
Quercetin stabilizes mast cell membranes, in effect turning down the allergic response signal. Quercetin also slows other mechanisms which are involved with inflammation, such as the production of inflammatory prostaglandins and leukotrienes. This adds to its membrane-stabilizing effect, and its value in allergy control.
Quercetin appears to substantially raise the threshold for initiation of an allergic reaction. In allergy sufferers this threshold is low, for reasons which are not well understood. They may have more IgE antibodies than normal, making the mast cells overly "trigger happy." Histamine has its proper place in the immune response that defends us against truly harmful foreign substances in the body. But like many chemicals produced by the body, histamine is a two-edged sword. In allergy-prone individuals, the mast cells have become overreactive, releasing too much histamine, unnecessarily. With quercetin in the bloodstream, histamine release from mast cells is kept under control. Quercetin's ability to down-regulate both the inflammatory and allergic responses makes it, I believe, a highly important nutrient for humans to consume on a regular basis.
Quercetin-the Scientific Evidence
Several studies, published in respected journals such as the Journal of Allergy and Clinical Immunology and others, have demonstrated quercetin's ability to control the release of histamine from mast cells. (Quercetin has the same effect on basophils, a type of white blood cell that also contains histamine.) In these experiments, mast cells taken from both animals and humans are exposed in the test tube to various substances—called "antigens"— that stimulate histamine release. The researchers then add an inhibiting agent such as quercetin to the mixture and measure the differences in histamine output. Quercetin has shown itself to be one of the more powerful histamine inhibitors, more powerful, in fact, than disodium cromoglycate, an anti-asthma drug.
Quercetin has other beneficial properties. A strong antioxidant, Quercetin has a higher level of antioxidant activity than both vitamin C and vitamin E. (Quercetin enhances the antioxidant activity of vitamin C; quercetin and vitamin C are true synergists.) Quercetin has been shown to block the oxidation of LDL cholesterol by free radicals. Quercetin also protects cell membranes from being injured by oxidized LDL. The damage that oxidized LDL causes to the delicate membranes of blood vessel linings allows plaque deposits to form, setting the stage for atheroslcerosis. These observations point to quercetin as a key nutrient for maintaining cardiovascular health.
Like all flavonoids, quercetin is not classified as an essential nutrient, although flavonoids were once called "Vitamin P." In view of its many beneficial actions, quercetin is a nutrient that clearly has important roles to play in human nutrition, for allergy sufferers, and for everyone.