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Study investigates health benefits of different cordyceps variants
May 10, 2019 02:22 PM
According to Taiwanese citizens, the cordyceps(mushroom) is a powerful food. They say it can help with the immune system, and fights against tumors, as a start. Though they are hard to grow in large volumes due to a parasitic symbiosis, they are still worth the effort to study and learn from. Taiwanese universities have already studied how fermentation affects this mushroom, and they want to increase their knowledge, especially when it comes to perhaps growing alternatives to meet the demand.
"In the review, the researchers identified the primary challenge in the mass production of Cordyceps sinensis, which is the difficulty in collecting natural variants with parasitic hosts, coupled with discoveries regarding its pharmacological benefits."
Read more: https://www.naturalnews.com/2019-04-19-health-benefits-of-different-cordyceps-variants.html
Cranberries prevent cancer and many other chronic diseases
November 24, 2018 11:13 AM
There are a lot of myths out there that are associated with the preventing of cancer. People who have come out and stated that they have the cure are immediately shot back down to Earth when their findings reveal almost nothing. However, doctors think that cranberries are actually important when it comes to preventing cancer. They have used them on many different subjects and the results are good. Not only do they help in preventing cancer, they help combating other chronic disease also.
"These not only support your immune system and cellular health, but they also help your body flush bacteria like E. coli from your urinary tract, which is why cranberry is often recommended for those prone to urinary tract infections."
Read more: https://www.naturalnews.com/2018-11-15-cranberries-prevent-cancer-and-many-other-chronic-diseases.html
Fo-Ti Root: The Medicinal Herb that Supports Skin, Hair & Brain Health
August 13, 2018 09:53 AM
Fo-ti is an herb widely used in traditional Chinese medicine as an invigorating, liver- and kidney-boosting tonic. It is also used as a remedy for hair loss and grey hair, a range of skin conditions like eczema, high cholesterol and other conditions. Primarily found in China, Japan, Tibet and Taiwan, fo-ti may have anti-inflammatory properties and be useful as sleep aid, treatment for hair loss or even a laxative. Fo-ti contains a mix of compounds that inhibit pro-inflammatory hormones in the body.
"The same review also point out that, “Laboratory studies and clinical practice have demonstrated that PM possesses various biological and therapeutic actions, including anti-tumor, antibacterial, anti-inflammatory, anti-oxidant, anti-HIV, liver protection, nephroprotection, anti-diabetic, anti-alopecia, and anti-atherosclerotic activities.”"
Read more: https://draxe.com/fo-ti/
NBC: Doctor researching cancer says common plant may hold cancer cure
December 25, 2017 07:59 AM
A researcher at Stephen F. Austin State University has found a new link between giant salvinia, a pest in Texas waterways, and a reduction in lung and pancreatic cancer. There are no details on what exactly in the plant is causing this decrease but the numbers are clear and hope is out there. This is part of a vanguard of disease and immunological studies to find cures from common plants and this looks to be promising
"Dr. Li says they found eight new compounds, with one of them showing anti-tumor activity."
Read more: https://www.healthnutnews.com/doctor-researching-cancer-says-common-plant-may-hold-cancer-cure/
Can Cannabis Actually Kill Cancer Cells In The Brain?
July 26, 2017 04:14 PM
Medical Marijuana use is no longer new. Many of us are aware of a loved one that has benefited from the pain-relieving qualities of the drug, even in advanced and serious conditions, like cancer. What may be less well known, or so far understood, is that it appears that Marijuana may be a potent adversary even against aggressive brain cancers.
Recent pharmaceutical research suggests research participants using the drug experienced a significantly prolonged rate of survival over non-users. This intriguing and hopeful research ties in handily with earlier research on rodents that shows the drug as having significant anti-tumor effects, such as inhibiting the growth of the malignancies, besides blocking the growth of new cells and ancillary blood vessels needed by the tumor. Also positive was the discovery that cannabis appears to make the use of chemotherapy more effective for brain cancer patients.
"Earlier this year, in what was heralded as a breakthrough for cancer research, GW Pharmaceuticals announced positive results from a study using a combination of cannabidiol and tetrahydrocannabinol to treat an aggressive form of brain cancer."
Read more: https://thefreshtoast.com/cannabis/can-cannabis-actually-kill-cancer-cells-in-the-brain/
Medicinal Value of Cannabichromene (CBC)
April 30, 2017 02:14 PM
A health fan blogger has written a feature touting the medicinal benefits of Cannabichromene (CBC). CBC is found in cannabis. The writer states that CBC relieves pain, reduces depression, fights bacterial and fungus infections, and can bring down levels of anxiety. It also acts an anti-inflammatory agent. The blogger backs up her statements with references to medical publications. The piece has a photo of the formula for CBC, plus a video about cannabis and its components.
"Studies have shown it safely and effectively provides a variety of therapeutic benefits, including improving pain, reducing inflammation, relieving depression and anxiety and inhibiting fungus growth."
5 Ways CBD Can Improve Health
March 16, 2017 04:44 AM
CBD is still controversial, but no one can argue with the results that science is giving us concerning this hemp-derived substance. Don't go another day without learning the array of medical benefits offered to your health when you use CBD. You might be quite surprised to learn the abundance of ways that CBD can help you feel your best day in and day out, but you will certainly like the information that you learn and will want to use it to your benefit.
"Cannabidiol (CBD) is a non-psychoactive cannabinoid found in marijuana, and science has given it close attention in recent years for its potential in treating a wide variety of medical conditions."
Read more: https://www.google.com/url?rct=j&sa=t&url=https%3A%2F%2Fwww.civilized.life%2Farticles%2F5-ways-cbd-improves-health%2F&ct=ga&cd=CAIyGmM2M2RhZjlmZTVmZDZjMmU6Y29tOmVuOlVT&usg=AFQjCNGRx_GLyElbd6ovLhDu2tG1_8AtEA
Exploring The Benefits Of Cat's Claw Herb
Cat's Claw is a medicinal plant made from the root and bark. It has drawn the attention of Western herbalists and researchers while being ranked seventh of the best selling herbs around the world. The plant has two components that are vital; Uncaria tomentosa angUncaria guianensis.
What Are Glycosaminoglycans (GAGs) And What Herbs Contain Them?
Glycosaminoglycans refers to a linear unbranched polysacharide chain molecule composed of disaccharides repeats with a high negative charge due to the presence of Uronic acid components and sulfate esters with some hydoxyl (OH) groups as part of its structural components. They have varying molecular size and sulfation depending on the tissue they are located on and their state. They function to attract cations and maintain the hydration of the extracellular membrane (E.C.M).
Glycoaminoglycans are classified into different groups based on different categories which include; glycosidic linkages in their structure, type of the sugar moiety, sulphate groups numbers and the location of the sulfate groups. Based on this various classification categories six major groups of GAGs exists, namely; heparin, hyaluronan, dermatan sulfate, heparin sulfate, chondroitin sulfate, and keratan sulfate.
GAGs have a high solvation degree and and are as well highly viscous. This is beneficial to the body in that it helps to cushion and lubricate various connective tissues and body joints respectively. It therefore protects an individual from joint pains due to poor lubrication of the joints causing the bone to slide over each other. They also form the building blocks of proteoglycans which are the major building blocks of the extracellular matrix. Due to this property they are vital in determining the cellular activities such as cell division because the cell division machinery has to attach itself to the extracellular matrix before the division process is initiated. Some body tissues such as the nerve cells and the muscle cells require continuous cell division to replace worn out cells for the normal functioning. This means that structural deformities in the extracellular matrix will hinder the division process to occur and is most likely to lead to some neurodegenerative complexions.
Recent studies have linked GAGs to play a role in the cell biology of cancer.They have been established as the key macromolecules affecting cell properties and functions through interaction with key growth factors or by acting directly as receptor molecules. Through this it has been findings they play a vital role in the cell signaling process thus playing a role in the cancer disease progression.Heparin and heparin sulfate have been indicated through studies to have anti-tumor effects by preventing the process of angiogenesis which is the first step in cancer metastasis.Some have been associated with anti-coagulant properties.
Therefore GAGs are important molecules which play a vital role in protection against various forms of cancers. GAGs aremostly obtained from animal sources. The animal sources include shark fish and ray skeletons. Plants are also sources of GAGs, however their digestion by the human system is not possible. Seaweed is one herb that is rich in GAGs. However as earlier explain the digestion of the sea weed by the animal digestive system is quite a challenge. It is therefore recommended that we eat foods rich in proteins, and carbohydrates which can be used to synthesize GAGs in the body.
In summary, GAGs are heteropolymers which acts as the building blocks of the extracellular matrix in animals. The body has the ability to synthesize GAGs naturally hence nutritional supplement is required for the body to obtain key components necessary for the synthesis.
Does Mangosteen Fruit Have Healing Properties?
March 25, 2014 08:22 AM
What is a mangosteen
The Mangosteen fruit is usually a Hawaiian sapling, started in this Southeast Asian nation. This sapling evolves from 7 to twenty-five feet high. This rind (pericarp or maybe peeling) with the fruit can be serious reddish violet while ready. Mangosteen fruit can be related directly to other Hawaiian fruits, but it contains simply no regards to this mango. Mangosteen fruit need to be stored humid to practical until germination, the idea dies rapidly when permitted to fail. Mangosteen fruit presumed to get a combination of vitamin richness, antioxidant strength as well as probable impact regarding reducing the danger in opposition to people ailments. This mangosteen fruit need to be harvested within a warm setting because exposures to help temperature ranges beneath 40oF (4oC) can kill this seed. Regarding the with the mangosteen fruit, it ought to be famous which Mangosteen fruit, generally known because "the queen regarding Hawaiian fruit", was launched to help BRITISH inside 19thcentury. From what individuals claim, King Victoria sampled this fruit in 1891, which the woman observed the idea fantastic.
Benefits of mangosteen
This particular wonderful fruit has been recognized due to the healing qualities. This rind (pericarp) with the fruit offers an incredible variety regarding natural and organic substances, among which can be Xanthones as well as tannic chemical which explains why the idea because already been for dysentery given that ages. Scientific research done around the healing utilizes with the mangosteen fruit ensures that a few substances inside rind with the mangosteen could have a few benefits in opposition to breast cancers, cancer of the blood, digestive tract cancers and thus onward. There are guaranteeing tips regarding other possible benefits down the route with the extraordinary qualities of the fruit. You can end, which mangosteen can certainly become a member of more information on plants that can be seen as guaranteeing sources of brand new medications. This particular seed is regarded as to give the strongest cause of xanthones (a kind of antioxidant) that may service the fitness of the complete human body. Thither are 20 various xanthones whole fruits that may produce potent physiological qualities.
Mangosteen research claims its compounds having antioxidant, anti-bacterial, anti-tumor action and essentially anti-inflammatory qualities. The item protects in opposition to no cost radicals by getting rid of bacteria, viruses as well as infection. The item reduces irritation as well as aids your body's therapeutic process. Mangosteen fruit features exposed to get an exclusive scope regarding potent people health improvements.
Astaxanthin Protects The Eye And More!
November 13, 2013 02:52 PM
Astaxanthin is a carotenoid that is commonly found in the marine environment. It is naturally found in salmon, krill, trout, crayfish, shrimp, crustaceans and yeast. It is the chemical that is responsible for the red color in cooked shellfish and salmon meat. The algae Haematoccus has the richest natural source of astaxanthin.
Astaxanthin can also be produced synthetically, but due to the synthetic product consisting of different steriosmers it is not preferred to be used in some cases.
Unlike beta-carotene it has two more oxygenated groups on each of its ring structure, these additional functional groups make it a highly potent antioxidant and give it a configuration that is more polar than that of other carotenoids. Vitamin E has been known as the strongest antioxidant both in topical use in cosmetics and in internal use, but research has shown that astaxanthin has a greater antioxidant strength than Vitamin E. For example in the quenching of singlet oxygen it has an antioxidant strength five hundred times stronger than Vitamin E.
Unlike many other antioxidants it has the ability of crossing the blood-brain barrier and enter into the eyes, brain and central nervous system (CNS). Most diseases of the CNS and eye are caused by increased generation of free radicals or by a decrease in the ability to remove free radicals from the body. Some of the diseases that are caused by problems with inflammation and oxidation include Glaucoma, Cataracts, and Huntington’s disease. These can be prevented by taking astaxanthin.
It has anti-inflammatory properties that are related to its strong antioxidants properties. It suppresses some of the inflammatory mediators such as, prostaglandin E-2 (PGE-2), tumor necrosis factor –alpha (TNF-a), and nitric oxide. Unlike other anti-inflammatory drugs like acetaminophen that can damage the liver and aspirin that may cause stomach bleeding, astaxanthin doesn’t have any side effects.
In people suffering from rheumatoid arthritis and carpal tunnel syndrome it has the ability of reducing pain. Studies have shown that it is able to reduce pain in rheumatoid arthritis by 40% after 8 weeks of continuous use.
It prevents Ultra Violet induces oxidative stress of the skin and prevents the photo aging of the skin. It prevents UV induced formation of wrinkles and collagen degradation in the skin. It may be applied on the skin or taken orally.
In people participating in sports it eliminates the soreness of joints after exercise, and reduces the pain caused by inflammation. This enables athletes to train harder and as a result increase their endurance, skill, and strength. This is through its ant-inflammatory and ant-oxidant effects in the mitochondria (energy producing organelle).
It strengthens the immune system, research by scientists has shown that it causes increase in production of T cells, stimulates the proliferation of lymphocytes, amplify the cytotoxicity of natural killer cells, decrease damage of DNA, and increases significantly delayed type hypersensitivity syndrome.
It prevents heart disease and reduces the risk of people already suffering from heart disease form getting a stroke or heart attack. It improves the blood lipid profiles by increasing HDL (high density lipoprotein) and decreasing LDL (low density lipoprotein).
The liver main function of the liver and kidney is the detoxification and removal of harmful substances in the body. These activities lead to the formation of free radicals. Astaxanthin being a strong antioxidant helps by destroying these free radicals hence it eliminates their oxidative effects.
As a result of its immune benefits Astaxanthin also has anti-tumor properties and as a result it prevents the development of cancer. Its prevention of cancer is also caused by its antioxidant properties and by it regulating gene expression.
How cat's claw as a natural immune system booster to treat and prevent diseases
November 01, 2013 07:51 PM
What is cat's claw plant
The root of the cat's claw plant, which is scientifically known as Uncaria tomentosa, contains compounds called pentacyclic oxindole alkaloids (POAs) that are responsible for its healing powers. The consumption of the cat's claw roots in raw or extract form must not be mixed with other foods that may neutralize the helpful effects of the POAs. The name cat's claw is Latin and represents this woody Amazonian vine that has only recently grabbed the attention of scientists who now use high performance liquid chromatography to see the POAs and isolate them for medicinal purposes. Here is an explanation of how the herb works to treat or prevent diseases.
What does cat' claw plant benefits
The alkaloids in the cat's claw herb are responsible for strengthening the immune system, but the specific benefits are as follows. In the digestive tract, the herb is able to treat Crohn’s disease, gastritis and duodenal ulcers, intestinal inflammation, parasites as well as balancing the intestinal flora. To the immune system itself, the herb stimulates the production of white blood cells to help combat arising problems of arthritis, rheumatism, chronic fatigue syndrome and infections by viruses or fungi. In South America, it serves as a birth control herb because of its associated properties of causing an unfavorable environment in the uterus thus preventing a fertilized egg from attaching to the uterus.
The anti inflammatory effects of the herb, together with its anti-tumor properties, all attributed to the alkaloids, prevent the damage of cells in the body by free radicals. As a result, patients having weak immune systems are able to significantly improve their chances of fighting diseases when they take in the herb as a supplement or tea. It’s the procyanidolic oligomers (PCOs) that stimulate phagocytes, which are special immune cells that destroy viruses and other organisms causing diseases. Excess use of cat's claw extracts or the herb itself can lead to nausea and headaches. The recommended dosage is 250mg of the extract taken twice in a day, or a teaspoon of cat's claw tea mixed with warm water, taken at most three times in a day.
Benefits of Extended Release Guggulipid
January 03, 2013 04:10 PM
Guggul is one of the holistic ancient herbal extracts derived from the Commiphora wightii plant that had been predominant in India although some parts of northern Africa and Asia still had some traces of the same. Over the years, Guggul resin gum derived from the plant has been used to promote a healthy living, and has a good number of recent scientific research findings to back it up. Some of the health benefits associated with the use of Guggulipids supplements (also known as the Guggulsterone Supplements) include lowering of Low Density Lipoproteins (Bad Cholesterol), reducing inflammation, and significantly lowering the risk of suffering from cardiovascular diseases, tumors and cancers.
Extensive scientific research shows that Guggulipids play an important role in inhibition of its synthesis in the liver and its hydrolysis into bile salts. It also acts on the thyroid gland which in turn controls the Basal Metabolic Rate that directly relates to the rate of cholesterol catabolism in the body. Additionally, a cascade of reactions in the liver during the process of cholesterol hydrolysis down-regulates the uptake of cholesterol in the gut which ensures that the body is at a healthy blood cholesterol level.
The anti-inflammatory, anti-tumor and anti-cancer effects are highly associated with the stimulation of the liver to release C-Reactive Protein. Even though the CRP protein is primarily produced by the body in response to inflammation and cell death, presence of the CRP in the blood stream prior to an acute inflammation or cell death plays an important role in toning down inflammatory conditions such as rheumatoid inflammation as well as killing abnormal cells before they develop into tumors and cancerous cells.
However, Guggulsterones are rapidly regenerated in the body in the same rate that other steroid hormones are degenerated which makes the use of extended release Guggulipid supplements very essential. This makes it possible to have the body under constant supply of the component for optimal guggulsterone health benefits.
Can Chaste Berry Help With PMS?
August 18, 2012 08:22 AM
Chaste berry is a kind of berry that grows in the Mediterranean region, and has many useful medical applications. Chaste berry is essentially a herb, belongs to the Vitex species, and is characterized by purple colored flowers that grow on it. It is grown widely in many parts of Africa. The plant grows up to 5 meters in height. Chaste berry has been in the mainstream media ever since studies showed that it helped women a lot in dealing with pre menstrual syndrome (PMS). While is has many other uses, both medical and non-medical, this particular functionality of chaste berry has been extensively noticed, as every woman in the world suffers from PMS quite a few times in their lives.
How is chaste berry useful with PMS?
Studies have shown by clinically proving that chaste berry helps women deal with PMS in many ways. A few of them are listed below:
Chaste berry helps keep the pituitary glands in check by acting upon prolactin secretion. Prolactin is a secretion of the pituitary gland that is associated with the breasts becoming tender in women during PMS. Thus by keeping it in check, one of the biggest causes of stress that women go through during PMS is reduced.
Chaste berry consumed in the tablet form has been proven to significantly reduce many of the PMS symptoms and effects that women go through. It has been concluded that most of the effects that chaste berry has with regards to PMS are sub-results of the bigger result, namely reduced prolactin secretion.
Unlike other clinically produced medicine, chaste berry is nature's own medicine to help cure the PMS blues, and it does a great job. As a matter of fact, the exact procedure that happens inside the body after consuming chaste berry is not comprehensible enough to the general audience, but the results speak for themselves.
Chaste berry extracts are available as tablets, and the effective dosage is one 20 mg tablet, up to three times a day. Consult your doctor for the exact prescription; this is just the general estimate. If you choose to take the drops, around forty drops per day will do.
What other uses does chaste berry have?
Chaste berry has many other uses, apart from belong with PMS.
Some of them are:
Chaste berry has been proven to help in prevention and control of prostate cancer. Anti-tumor behavior of chaste berry on the cancerous cells has been observed, thus establishing the fact that chaste berry helps in prostate cancer.
Chaste berry has also successfully helped in breast pain, which is medically called mastalgia. The effects are well researched and documented.
With relation to controlling the prolactin secretion as stated above, chaste berry ultimately helps prevent and control Hyperprolactinaemia, which is essentially the presence of the hormone in large quantities in the blood. This can sometimes lead to problems in breast milk production, and breast feeding.
The best part about chaste berry is that it has absolutely no documented side effects. The only piece of advice associated with chaste berry is that it should not be consumed during pregnancy, as might cause some complications later on. All said and done, chaste berry does help with PMS, no doubt about that.
What Are The Health Benefits Of Saffron Extract?
March 26, 2012 08:01 AM
HEALTH BENEFITS OF SAFFRON EXTRACT
Saffron is one of the rarest and exotic spices found on the earth. Golden spice is the other name given to saffron, attributing to its reddish-golden color. It is the most common spice used in many Indian,Mediterranean and Italian cuisine. This culinary and exotic spice grows on a flowering plant- Crocus Sativa. It is grown in various countries around the world including many Asian and European countries. Areas with hot dry summers and wet springs are the most suitable areas for growing Saffron. While saffron is popular for its flavor, color and fragrance, this rare spice also, has many medicinal and health benefits. Saffron is a very expensive spice and this is mainly because of the fact, that for making 1gram of Saffron strands 150 flowers are required.
Mineral present in Saffron extract -
Saffron extract contains high amounts of copper, magnesium, calcium, zinc, potassium, iron, and selenium. It is also a rich source of various vitamins like- vitamin A, B2 and C, niacin and folic acid. Apart from these Saffron also contains carotenoid compounds - crocetin, lycopeneand, safranel and crocin.
The various health benefits of Saffron are -
1) Cancer Treatment- Because of the presence of crocetin and carotenoid in Saffron, it has anti-mutagenic and anti-tumor properties. Several studies on Saffron extract have proved that Saffron extract delays papilloma carcinogenisis and tumor growth. Because of all these properties, Saffron extract can be used for treating and preventing skin cancer, liver cancer and sarcoma.
2) Anti-inflammatory properties- Saffron have anti-inflammatory properties and therefore it can be used in treatment of arthritis and other inflammatory diseases. It is capable of controlling inflammation and healing cuts and burns faster.
3) Potent aphrodisiac- For last many centuries, Saffron has been used as a “POTENT APHRODISIAC” inPersiaand many other Arabian countries. It can increase libido and improve erectile dysfunction by increasing the flow of blood in the pelvic region.
4) Eye Care- Several studies have proved that Saffron extract can treat certain eye problems like- macular degeneration and retinitis pigmentosa. Saffron also protects the eyes from the harmful effects UV rays.
5) Anti-Depressants- Saffron extract can also be used in the treatment of patients suffering from depression. Researches have shown that Saffron gives equal results as given by therapeutic drugs like imipramine and fluoxetine.
6) Painkiller- Saffron extract can be used for treating many severe painful conditions like- stomach pain, menstrual pain, and kidney pain.
7) Weight loss- Researches have shown that Saffron can suppress the feeling of hunger, by controlling the percentage of serotonin content in the blood. Therefore, Saffron is used in many weight loss programs, as it can reduce the compulsion to eat and feelings of hunger.
8) Skin- Saffron contains antioxidants, and therefore it is used in many beauty and anti-aging treatments.
9) Saffron during Pregnancy- During pregnancy, women are advised to drink Saffron milk, in order to enhance their pelvic blood flow. Also, due to its Carminative properties it helps in suppressing cramps.
Gas and bloating are very common problems during pregnancy and just one glass of Saffron milk can reduce flatulence and ease digestion.
Cat's Claw Bark
December 19, 2008 09:54 AM
We are currently living in a time when vital health issues that greatly affect our families are a huge concern. Cat's claw has been shown to offer a huge array of therapeutic actions, as it is currently drawing a huge amount of attention in health-care. Because cat's claw has anti-tumor, anti-inflammatory, and anti-viral capabilities, it is currently being widely used in Europe for the treatment of cancer, aids, arthritis, and several other degenerative diseases.
Cat's claws emergence could not have been better timed, as many people feel that the war on cancer is being lost, with new potentially fatal viruses continuing to evolve and the over-prescription of antibiotics making us even more vulnerable to infection. Recently, taking supplements such as cat's claw is becoming more of the rule than the exception.
It is safe to say that almost all of us want to know how to reduce our risk of cancer, protect ourselves from toxins and pollutants, boost our immune system to fight off new viral strains and bacterial diseases, and prevent premature aging and degenerative diseases. Additionally, many of us have found that treating the disease after the fact is much less desirable than the protecting our immune systems, as a well-nourished and healthy immune system can keep us from developing diseases, including cancer. Cat's claw has the ability to fortify immunity, works to scavenge free radicals, and eases inflammation.
Cat's claw was traditionally used by Peruvian natives in a variety of applications. They apply its leaves for headaches, use teas for infections including influenza, and have placed plants in antipyretic baths for fevers. Additionally, gargles are used frequently and poultices of the boiled crushed bark have been applied to affected areas. Peruvian tribal medicine has also vigorously rubbed infusions of the raw bark on parts of the body, such as the limbs. The vines of cat's claw are often macerated with a pestle or stems are allowed to stand in water for several hours. In Peruvian culture, snuffing or smoking the dried leaves or bark occurs on occasion. Also, enemas are used in some regions of the tropical South America, but they are relatively rare in the Amazon.
Cat's claw can be taken in many forms including a dried, powdered form that is usually available in gelatin capsules; compressed tablets; a decoction or tea; or a liquid suspension that are in the form of gels or extracts, which can often be taken in soft gelatin form. Some experts seem to think that cat's claw extracts have not yet proven their potency and therefore, they recommend taking reliable sources of the plant which use the inner bark of the vine. The alkaloid content of some plants can vary significantly because of many different factors, so only reputable sources of cat's claw are recommended to be purchased.
Many studies that have taken place in Europe have shown that cat's claw has extremely low toxicity, even when it is taken in large doses. Anyone who has had a transplant or any pregnant or nursing women should not take cat's claw. Taking cat's claw can potentially cause diarrhea or adjust bowel consistency in some people.
If one is looking for a immune boosting herb from the Amazon look no further, cat's claw can help the sick get well and keep the healthy person free from disease by boosting the immune system.
NK Immune Boost
September 25, 2008 03:59 PM
The immune system is the ultimate bodyguard that can prevent illnesses before it even takes hold in the body when it is properly taken care of. Immune impairment has become a major concern within recent decades among health professionals. The strength of the immune system directly influences the quality of health. However, it is often something that we take for granted. There are a lot of things that can interfere with proper immune function, including diet, stress, and level of activity. It is within our ability to create a health immune system for ourselves.
If we do something that makes us a little bit healthier, we will experience less disease and suffering. Each of us individually must do what is necessary to protect ourselves from common health threats that can occur if the immune system is compromised like heart disease, arthritis, fibromyalgia, gastrointestinal problems, AIDS, cancer, and many other illnesses. We will be able to avoid disease and the suffering it causes if we do what is necessary to keep our immune system healthy and balanced.
In order to understand how to fight against health problems in the best way, it is necessary to first understand the basics of how the immune system functions. The smallest components of the immune system are biomolecules, which are also called immune factors or immuno-regulatory molecules. The immune system fights against the potential health dangers by identifying and then eliminating dangerous and unfamiliar particles, which include bacteria and viruses. The immune system can very selectively discriminate between self and non-self, a trait that is extremely unique. It then destroys the foreign antigens and leaves itself alone.
Biomolecules called cytokines work to regulate and simulate the body’s defense system. Cytokines help to fight against foreign molecules, also called pathogens, by inducing the production of antibodies. These antibodies work to neutralize antigens and create immunity to them. Additionally, a functioning immune system remembers the foreign antigens that it has encountered before so that it can prevent or quickly defeat secondary attacks by the same pathogen.
There are many immunity agents that are found in the body. An antibody is a molecule of the immune system that is secreted into the blood and helps to fight against antigens like bacteria and parasites to help create immunity, Antigen are substances that stimulate the production of an antibody when it is introduced into the body. Antigens include toxins, bacteria, foreign blood cells, and the cells that are found in transplanted organs. Colostrum, antibody-rich milk, is produced by a mother during the first week of her child’s life. Cytokines consist of any of several regulatory molecules that are released by cells of the immune system and acts as a mediator in the generation of an immune response. Cytokines assist in the regulating and controlling of the immune system.
Interleukin is a type of cytokine which encourages the growth of immune cells. There are many types of interleukins, with three of the most common stimulating the inflammatory response, the growth of blood stem cells, and the production of helper T cells. Pathogens are agents that cause disease, while tumor necrosis factor is a type of cytokine that has anti-tumor properties. It affects blood vessels, therefore, regulating both inflammation and killing tumors. Lastly, white blood cells help to protect the body from infection and disease.
Keeping the immune system in tip top shape is very important. There are a variety of natural substances such as colostrum that can help the immune system function at optimal levels. Natural supplements are available at your local or internet health food store.
September 24, 2008 09:17 AM
Balance is crucial for a healthy immune system. A variety of stressors such as bacteria, parasites, pollutants, strong emotions, and improper diet, can cause the immune system to become imbalanced. If the immune system is weakened then it is less able to fight against invading antigens. Disorders and reactions such as allergies, arthritis, multiple sclerosis, fibromyalgia, lupus, Crohn’s disease and diabetes can also occur if the immune system is overactive and begins to fight against itself. However, if the immune system is healthy and balanced, the body will be protected and healed from foreign invaders. But if the immune system is under active or non-responsive, it is susceptible to infection, illness, and emotional distress. By supplementing with natural immune modulators, the immune system can achieve and maintain optimum balance.
Cytokines consist of a variety of multifunctional molecules which work to regulate and control the body’s defense system. These biomolecules are crucial for optimal immune function as they play a key role in immunity, infectious disease, blood production, tissue repair, and cellular development and growth. Cytokines actually play an important role in a variety of body functions, ranging from general maintenance and the regulation of inflammatory responses to the direct interference of invading pathogens.
Cytokines are also important messengers that are used by the immune system to inform the rest of the body that an infection has been discovered. Any immune system imbalance can lead to interference between cytokines and proper body function. Different cytokines have different actions on the same cell. However, there is a large degree of overlap between the actions of one cytokine and another. Cytokines have been given a variety of names throughout the years including chemokines, monokines, interferons, interleukins, lymphotoxins, lymphokines, and leukokines. Cytokines are part of large signaling network that have additive, inhibitory, and synergistic effects.
The most important immune functions are carried out by groups of cytokines that are known as interleukin 1 and 2, interferons, and tumor necrosis factor. They help to modulate the immune system when the tissue is being threatened or damaged. Interleukin 1 helps to protect against the effects of radiation and encourage the growth of immune cells, while tumor necrosis factor is produced in response to bacteria and other disease-causing agents. Additionally, tumor necrosis factor also promotes the production of more cytokines. Tumor necrosis factor also has anti-tumor properties which increases the activity of other cells that fight tumors and also affects the blood system in tumors. It also effectively helps to slow down or reverse tumor growth by starving cancer cells of the nutrients they need and reducing blood flow.
Researchers are currently looking at treating various disorders with cytokines because it is clear that cytokines link the immune system to other physiological systems. Because of the intricate network of the cytokine processes, many researchers believe that the treatment of various immune disorders could potentially require a combination of immuno-regulatory factors. Many scientists are trying to recombining cytokines; however it is extremely limited because they are extremely expensive; they may be toxic and cause symptoms such as fever, muscle aches and fatigue; and they may create imbalances in the patient that would not benefit them.
As a result of these facts, researchers are turning their attention to a natural immune modulator such as hyperimmune egg and colostrum. Hyperimmune egg and colostrum can stimulate the production and activities of powerful immune agents and jump-start the body’s own defense system, instead of having to rely on drugs to fight invading pathogens.
EFA's - Essential Fatty Acids
September 15, 2008 09:42 AM
Many recent studies have found that EFAs may be extremely helpful for many chronic, stubborn conditions. Their continuously growing range of applications includes overcoming diseases such as alcoholism, breast cancer, and cardiovascular disease; strengthening the immune system; helping eliminate yeast infection; reducing symptoms of premenstrual syndrome; minimizing inflammation of rheumatoid arthritis; and assisting in the proper management of weight.
Alcohol dependence is an extremely serious condition that often results in decreased life expectancy, suicide, degeneration of the brain and liver, osteoporosis, and many other conditions. For each person, the rate at which alcohol is metabolized in the body is different, as a lot of it has to do with the person's nutritional status, the concentration and activity of liver enzymes, and the rate at which alcohol is consumed.
Alcoholics tend not to eat because the calories from alcohol, although nutrient-poor, diminish the appetite, causing many alcoholics to become extremely malnourished. An overall nutritional program should be employed to those people who are dependant on alcohol, which should include vitamins A, C, and B, complex, along with zinc, magnesium, selenium, amino acids, milk thistle, acidophilus, antioxidants, L-carnitine, and essential fatty acids. EFAs, especially those that are high in GLA, keep blood lipid levels from going out of control.
The body's immune system has a vital role in protecting us against cancer, as it recognizes and annihilates any abnormal cells before they have the chance to multiply and do damage. When the immune system is overwhelmed or not functioning properly, abnormal cells will reproduce without having anything to stop them. Because of the rapidly growing tumors which have a huge appetite for nutrition to keep them going, cancer patients often become malnourished and lose weight. A diet that is rich in cruciferous vegetables, fiber, antioxidants, vitamins A, C, and E, minerals, and essential fatty acids can help prevent breast cancer. Research shows that EFAs, especially GLA, have anti-tumor properties.
All of the cells in the body have a dependence on nutrients that are transported through the circulatory network. When blood vessels become clogged with fats and cholesterol, nutrition distribution is hindered and blood flow can be stopped in some areas, causing the heart to die. Exercise is a good for increasing circulation and keeping the blood from getting stuck. A diet that is high fruits, vegetables, natural fiber, and low in saturated fats, meats, and homogenized dairy products is also a good idea. Additionally, antioxidants, hawthorn berry, ginkgo biloba, vitamin E, Co Q-10, L-carnitine, calcium, magnesium, potassium, and EFAs will also be of benefit to the cardiovascular system.
Essential fatty acids have been shown to stop the growth of yeast organisms in the body. They do so by helping the oxygen to flow to cells. Since yeast is anaerobic, it cannot thrive in the presence of oxygen. Yeast overgrowth can cause a variety of symptoms that are often diagnosed as another condition, ranging from joint swelling to memory loss.
PMS is a collection of symptoms that occurs one to two weeks before menstruation, affects about one-third of women who are younger than forty. It is caused by hormone imbalances, which result in anxiety, irritability, and mental sluggishness. Research has found that women with PMS usually eat more refined carbohydrates, dairy products, and sodium, and less iron and other minerals than those women who do not experience this condition. Vitamin B complex, beta carotene, vitamin E, magnesium, milk thistle, acidophilus, and essential fatty acids are very helpful for PMS. Essential fatty acids, especially GLA, are helpful in balancing the body's hormone levels.
Reducing symptoms of disease like arthritis or PMS is important to all those who suffer from them. EFA's can help reduce the symptoms of these diseases. American diets are low in EFA's and one should consume them either in the foods they eat or supplement form to help the body strengthen its self and fight off disease.
Give Your Health A Boost With Beta Glucan
February 19, 2008 04:54 PM
Beta Glucan is a little-known component of many common foods we eat on a daily basis. Cereal, mushrooms, and even baker's yeast contain beta glucan. The substance is most common found in such grains as barely and oats. Beta glucan is often used in soluble fiber supplements. The FDA has given baker's yeast the rating for being generally safe (G.R.A.S.).
Beta Glucan has been studied in Japan for its anti-tumor and anti-malignancy properties. It is commonly known worldwide to have a significant impact on improving the human immune system. The clinical applications have been many for this substance. Beta glucan has been studied for preventing infection in post-operative patients. Likewise, it has been attributed with slightly faster, more efficient healing of wounds. Beta glucan has helped patients with septic shock.
This substance has also been studied for its effects on individuals suffering from arthritis. Beta glucan has been attributed with slowing the disease's progress and preventing further damage to tissues. Beta glucan has been studied for decades, however was too expensive for the general public until recent times. It has no known reactions with prescription medications and beta glucan supplements derived from baker's yeast isn't know to contain enough to cause a reaction in those with yeast allergies.
There are also on-going studies regarding beta glucan and it's usefulness with radiation and radiation exposure. There is a great deal of interest that this can perhaps lessen the severity of symptoms from radiation in chemotherapy and help those experiencing nuclear therapy or who are involved in a nuclear emergency.
Beta glucan is one of the few nutrients that are recommended for both humans and animals. It is also advised for those who have poor daily nutrition, athletes, those regularly exposed to radiation, individuals under stress, or anyone who wants to stay healthy. In truth, studies indicate that consumption of oats, cereal grains, and other beta glucan containing products can lower cholesterol, can aid in overcoming intestinal problems, and can benefit those diagnosed with AIDS and multiple sclerosis.
Beta glucan strengthens the cells responsible for fighting foreign invaders in the body such as viruses, bacteria and even parasites. It helps these cells be more responsive and stronger when free radials enter the body. One study in Canada evaluated the response of beta glucan to Anthrax. As a result, the beta glucan proved to be a very effective supplement to the antibiotics used in treating this disease.
Higher dosages do not equal effectiveness. Beta glucan is not measured by the size or milligram of the supplement. The determining factors for the effectiveness of beta glucan involve how the substance is processed and if the particular pill re-aggregates during the digestive process. If your supplement re-aggregates, it will not have the same effective nature as those that do not.
Be sure to evaluate the labels and inspect the image the company is portraying. If a product is "too good to be true," it is. As always, consult with your physician before starting this or any other long-term supplement.
Mushrooms are good for the Immune System
January 26, 2007 06:12 PM
Medicinal Mushrooms Grown on Purple Kculli Corn Yield Life Changing Results
Even though we treat them like vegetables, mushrooms aren’t really plants. They’re fungi and fungi grow much differently than fruits and vegetables. Most food plants, like strawberries, broccoli, and red bell peppers make chlorophyll from sunlight to gain the nutrients they need to grow. Mushrooms don’t make chlorophyll; to get the nutrients they need to grow, mushrooms release enzymes into the forest floor or flora they’re living on to break down the organic matter into a form the mushroom can absorb.
Because most mushrooms that we eat or use today are raised as crops, or cultivated, they are grown on a variety of substrates. Similar to the commercial potting soils you can buy at nurseries and garden stores, mushroom substrates vary widely in quality and the kinds of nutrients within. Mushrooms are really unique in that they can grow on almost anything, such as sawdust, shredded newspaper, and straw.
However, mushrooms are only as nutritious as the substrate they were grown on-even those unique varieties called medicinal mushrooms. While the simple button mushrooms found on pizza are most often eaten for their woodsy taste and texture, the use of medicinal mushrooms is much more complex. These mushrooms are valued because they contain numerous compounds that have been extensively studies by researchers for their ability to activate cells of the immune system.
Researchers have recently discovered that when medicinal mushrooms are grown on a Purple Kculli (pronounced ka-coo-lee) Corn substrate, the resulting mushrooms are jam-packed with powerful and potent disease-fighting compounds. Beautiful Purple Kculli Corn has long been used by the people of the Peruvian Andes as a tasty vegetable, natural food color, and powerful functional food-keeping them healthy and free of disease.
In this issue of Ask the Medicine Hunter, we’re going to talk about four powerful medicinal mushrooms that, when grown on Purple Kculli Corn, have even more potent compounds to prevent and treat cancer and other serious health problems.
Q. How exactly do medicinal mushrooms prevent and treat cancer?
A. Medicinal mushrooms are very complex. They contain numerous compounds that have been extensively studied for their ability to activate cells of the immune system. Some of the most amazing immune boosting compounds in medicinal mushrooms are beta-glucans 1-3, beta glucans 1-6, arabinogalactins, and arabinoxylans – compounds that work “hand-in-hand” with certain cells of the immune system. But to get abundant amounts of these compounds, medicinal mushrooms must be grown on substrates with high levels of nutrients. And the most nutrient dense substrate of all comes from Purple Kculli Corn.
Q. Why is Purple Kculli Corn extract good for growing medicinal mushrooms?
A. You’ve probably heard that brightly colored fruits and vegetables (like beets, broccoli, and blueberries), have more antioxidant power than paler fruits and vegetables (like iceberg lettuce, onions, and garlic). In fact, the deeper the color, the better. And there is no deeper color in nature than the deep purple of Purple Kculli Corn grown in the lush coastal plains of Peru. The kernels from Purple Kculli Corn are not only naturally beautiful, the pigment itself is extremely healthy and have been used by the people of the Peruvian Andes for centuries as both food and food coloring.
Once harvested, the Purple Kculli Corn is naturally processed into an antioxidant-rich extract. When certain medicinal mushrooms are grown on Purple Kculli Corn extract, the Purple Kculli Corn becomes a super-substrate, producing medicinal mushrooms with incredible amounts of the immune-boosting compounds. And when Purple Kculli Corn extract is added to medicinal mushroom formulas the antioxidant power increases, too.
Q. How do the medicinal mushroom compounds fight disease?
A. When bacteria, viruses, or other pathogens are present in the body, white blood cells, or leukocytes, swing into action. Leukocytes work together to defend the body against infections, like colds or the flu, as well as diseases that start within us, like cancer. These disease fighting cells are the backbone of the body’s defense system. And each type of cell works in different ways.
The macrophage, a name that means “big eater,” is a first-strike leukocyte that protects us from disease by, quit literally, devouring invading pathogens. Natural Killer (NK) cells act like sentries – constantly prowling for cancer cells, killing them quickly when they’re discovered. B-cells are the immune system’s military intelligence, seeking out targets and communicating their coordinates, while T-cells are the foot soldiers, destroying the invaders that the intelligence system has identified.
Scientists have long known that medicinal mushrooms help make white blood cells more deadly. But until recently, they weren’t sure how. Research has now shown that macrophages and NK cells have receptor sites specifically for beta-glucans 1-3 and beta-glucans 1-6. When the beta-glucans bind to the macrophages and NK cells, they make the lymphocytes stronger and more lethal. By increasing the lymphocytes’ strength, beta-glucans help them churn out more of the specialized chemical messengers, too.
Arabinogalactins and arabinoxylans, powerful polysaccharides found in medicinal mushrooms, are potent stimulators of the immune system. These compounds increase the activity of interleukins, interferons, and a tumor necrosis factor, all key components in a healthy immune system. When medicinal mushroom extracts with high amounts of Arabinogalactins and arabinoxylans are taken, diseases are dramatically reduced.
Researchers found that complex polysaccharides in four varieties of medicinal mushrooms – Agaricus blazei (Agaricus), Grifola frondosa (Maitake), Coriolus versicolor (Coriolus or Turkey Tail), and Ganoderma lucidum (Reishi) – are serious cancer fighters. The chart below explains how:
Mushroom Health Benefit
Agaricus (Agaricus Blazei)
Agaricus not only contains the greatest number of medicinal compounds, it also contains a powerful anti-tumor polysaccharide that all other medicinal mushrooms are lacking. Recently, 100 women who were receiving carboplatin, a chemotherapy drug used to treat ovarian cancer, volunteered for an important study. Half of the women were given an extract of Agaricus mushrooms, while the other half were given a placebo or dummy pill. The researchers discovered that NK cell activity was significantly higher in the Agaricus group. The women in this group were also less nauseated, fatigued, and wear than the women taking the placebo, an important consideration for people with cancer.
Maitake (Grifola Frondosa)
Maitake is one of the most researched of all medicinal mushrooms. In one clinical study, the effect of Maitake mushroom compounds were studied in ten patients with cancer who were not currently taking any chemotherapeutic drugs. The researchers found that the Maitake not only significantly stimulated NK cell activity, it also repressed the cancer’s growth, and stopped the tumors’ ability to metastasize, or spread to other parts of the body. And in another clinical study, 165 patients with various types of advanced cancer were given Maitake mushroom compounds alone or with chemotherapy. Cancer regression or significant symptom improvement was observed in 58% of liver cancer patients, 69% of breast cancer patients, and 62% of lung cancer patients. Plus, when Maitake was taken in addition to chemotherapy, the immune cell activities were enhanced 1.2 to 1.4 times, compared with chemotherapy alone.
Versicolor compounds show great promise as cancer immunotherapy agents in all cancer stages. In one clinical trial, 34 patients with advanced terminal lung cancer were given Coriolus versicolor polysaccharides or a placebo (dummy pill) for 28 days. While the group getting the Versicolor felt less fatigued and sick, very important considerations at the end-of-life, there were no changes in the placebo group.
Reishi (Ganoderma Lucidum)
Reishi mushrooms are too tough to eat, but they’ve been used medicinally for centuries and have been extensively researched. In a safety study to determine Reishi’s effect on blood thinning mechanisms, healthy volunteers received 1.5 gm Reishi or placebo daily for 4 weeks. There were no significant changes in either group and all blood clotting measurements remained within the normal range, demonstrating its safety. In a recent clinical study, researchers determined that Reishi increased the number of cancer killing white blood cells and made them more deadly to cancer cells.
Not only do Agaricus, Maitake, Coriolus, and Reishi have incredible amounts of immune boosting polysaccharides, when they are grown on Purple Kculli Corn, they also have a much higher ORAC value than mushrooms grown on other substrates.
Q. What are ORAC values?
A. ORAC, or Oxygen Radical Absorbance Capacity, is a measurement of the antioxidant power in fruits and vegetables. The higher the power, or ORAC value, the stronger the antioxidant is against free radicals. While free radicals are made by breathing oxygen and digesting food, and are simply the consequences of being alive, the older we get the more free radicals we make. And the more free radicals we make the more destructive they can be. Free radicals will rip membranes, wreck cells, cripple mitochondria, and ruin DNA. As this damage accumulates, even more free radicals are made. And if not stopped or slowed, this might lead to heart disease, arthritis, diabetes, dementia, and cancer.
Q. How does Purple Kculli Corn increase the ORAC value of medicinal mushrooms?
A. All brightly colored fruits and vegetables have very high ORAC values; and the higher the ORAC value – the greater the antioxidant power. Not only can we measure the ORAC values of fruits and vegetables, we can also measure the ORAC values of mushroom substrate extracts. Purple Kculli Corn extract has an ORAC value of 1789 (measured in umolesTE/gram). Now, remember that mushrooms are fungi, not fruits and vegetables, and they gain most of their nutrients from the ground (or substrate) they are grown on. When mushrooms are cultivated or “farmed” on substrates with a high ORAC value, they will absorb compounds from the substrate giving them a higher ORAC value, too. So growing mushrooms on antioxidant rich, high ORAC value, Purple Kculli Corn yields medicinal mushrooms with high ORAC values as well.
Q. Some mushroom supplements have more than four medicinal mushrooms. Wouldn’t a mushroom supplement with seven mushrooms or more have a higher ORAC value than a supplement with only four?
A. Well, more is not always better – especially when it comes to medicinal mushrooms. Some supplements have a “kitchen sink” selection of mushrooms. The makers of these supplements hope that by adding modest amounts of many mushrooms, they will end up with a product that just might have some health benefits.
Clearly, it’s not how many or how exotic the mushrooms are in a medicinal mushroom supplement, it’s the substrate that mushrooms are grown on that makes the difference.
Q. How can I make sure the medicinal mushroom supplement I buy contains natural and organic mushrooms grown on Purple Kculli Corn substrate?
A. Become a label reader! Medicinal mushroom formulas have a statement showing accreditation from a certifying agency, such as the American Food Safety Institute, International; California Organic Farmer Association, Minnesota; or Crop Improvement Association, on the label, and have met certain criteria. They must be grown without chemicals or pesticides. The growers must be certified as organic mushroom produces by an accredited third party. And the growers must keep a record of their production and handling practices.
Of the nearly 38,000 varieties of mushrooms, Agaricus blazei, Grifola frondosa, Coriolus versicolor, and Ganoderma lucidum have impressive medicinal properties. With a little help from Purple Kculli Corn, these mushrooms can provide even more potent and powerful cancer preventing properties for superior mushroom supplements.
Immune Renew Fact Sheet
December 07, 2005 01:07 PM
Immune Renew Fact Sheet Neil E. Levin, CCN, DANLA 02/10/05
LIKELY USERS: Everyone seeking a healthy immune system; People on low carb diets or non-whole grain diets that are lacking dietary beta-glucans
KEY INGREDIENTS: Astragalus Root Extract Powder 70% polysaccharides (200 mg). Proprietary blend of 8 organically grown “medicinal mushrooms” (200 mg)
MAIN PRODUCT FEATURES: Vegetarian formula. Polysaccharides in these US-grown mushrooms grown on organic brown rice include 1,3 Beta-glucans and terpenoids. Beta-glucans may stimulate the immune system in different ways. Triterpenoids may act as mild anticoagulants. Each mushroom may have a different effect; for example, one may stimulate T-cells and another Natural Killer cells, aiding in immune defense. Mushrooms have reported beneficial effects on liver health and promoting normal cell growth.
ADDITIONAL PRODUCT INFORMATION: Some extracts from these kinds of mushrooms have been used medicinally in Japan and China. The mushrooms include Turkey Tail, Sun Mushrooms, Maitake, Cordyceps, Phellinus, Lion’s Mane, Reishi and Shiitake. The astragalus extract also contains naturally occurring astragalosides. Mushrooms may help maintain normal cholesterol and triglyceride levels
SERVING SIZE & HOW TO TAKE IT: For everyday use take one or two caps per day, either with meals or on an empty stomach.
COMPLEMENTARY PRODUCTS: Vitamin C to break down beta-glucan structures for better absorption, Inositol Hexaphosphate (IP-6), I3C, Pometrol, mixed carotenoids and antioxidants
CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. Do not take with AIDS drugs or if you have an autoimmune disease. Use with caution if using anticoagulants or blood pressure medication, as these mushrooms may have mildly synergistic effects to those drugs. Do not use if you have mold or mushroom allergies (or any sensitivities to mushrooms, cheese, etc.), which can potentially result in hives, rashes, breathing difficulties (including dry mouth or throat), stomach distress, diarrhea, or any other unusual side effect.
This information is based on my own knowledge and these references, but should not be used as diagnosis, prescription or as specific product claims.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995
June 25, 2005 09:58 AM
Garlic can rightfully be called one of nature’s wonders. It can inhibit and kill bacteria, fungi, parasites, lower blood pressure, blood cholesterol and blood sugar, prevent blood clotting, protect the liver and contains anti-tumor pro p e rties. If that wasn’t impre s s i ve enough, garlic can also boost the immune system to fight off potential disease and maintain health.
Garlic has the ability to stimulate the lymphatic system which expedites the removal of waste from the body. It is considered an effective antioxidant and can help protect cells against free radical damage. In addition, it nourishes and supports the heart, stomach, circulation and the lungs. Current research suggests that garlic may help prevent some forms of cancer, heart disease, strokes and viral infections.
Garlic alone can provide us with over two hundred unusual chemicals that have the capability of protecting the human body from a wide variety of diseases. The sulphur containing compounds found in garlic afford the human body with protection by stimulating the production of certain beneficial enzymes. Most experts agree that garlic does not have to be eaten in its raw form to be effective. Cooked garlic or various aged extracts and oils can in some cases provide better protection against free radicals and infection than raw garlic. In countries like Germany and Japan, it is customary for large segments of the population to take a garlic supplement on a daily basis.
What is the difference between the types of Ginseng?
June 17, 2005 12:45 PM
What is the difference between the types of Ginseng?
Ginseng has been used for thousands of years by the Chinese and Native Americans. The Chinese name, Ren Shen means "Man-Root" because it is shaped like a human. There have been over 3,000 scientific studies published on Ginseng. Studies have examined the anti-tumor, anti-infective, nervous system, lipid lowering, and anti-fatigue activity of ginseng. Experimental research indicates that Ginseng helps the body adapt to stress, protects the body against radiation, and increases sperm count, and stabilizes blood sugar levels.
Ginseng can differ depending upon the species, the way it is prepared, and of course the dose administered. There are two main kinds of Ginseng: American and Asian. American Ginseng, Panax quinquefolium, grows wild in many states although it is cultivated mainly in Wisconsin. American Ginseng generates body fluids and is said to clear heat. Those who can benefit most from American Ginseng are individuals that are under stress, athletes, and people who feel hot and thirsty. They may also have coughing, or coughing up blood, which indicates heat according to traditional Chinese Medicine.
Asian Ginseng, Panax Ginseng, is usually imported to the US from either China or Korea. It is traditionally used to treat cold syndromes, which include cold limbs, weak pulse, exhaustion, and shortness of breath. White Ginseng usually refers to untreated ginseng, and is said to be less warm than red Ginseng. Typically red Ginseng is steamed and cured with other herbs giving it a dark red appearance; most Korean Ginseng is red.
A common substitute for Ginseng in the US and China is Codonopsis, known botanically as Codonopsis pilosula. It has similar effects to Asian Ginseng: it is not as strong and not nearly as expensive. Eleuthero Ginseng, sometimes referred to as Siberian Ginseng, is really not ginseng at all but is in fact a distant cousin. It belongs in a different botanical species: Eleutherococcus Senticosus. Eleuthero Ginseng grows in northern China and Russia. Although it is used to help the body adapt to stress, it is less specific as a medicinal herb than Asian or American Ginseng.
Traditional herbalists rarely use ginseng by itself. Herbs are usually combined with other ingredients in order to increase clinical benefits and reduce negative reactions. For example, Generate Pulse Powder (Sheng Mai San) is a traditional combination, which often combines America Ginseng with herbs to moisten the lungs; therefore it can be used for chronic cough that is difficult to expectorate, and shortness of breathe. Bu Zhong Yi Qi Wan is an ancient formula that has been used for at least one thousand years to treat patients who are exhausted, feel cold, and may have weak limbs and/or chronic loose stools. In this ancient formula, Ginseng is combined with Astragalus and other harmonizing herbs, which help the body assimilate ginseng. Modern formulas with Ginseng or Codonopsis, have been used to help people overcome serious conditions such as impotence, Chronic Fatigue Syndrome, and fibromyalgia. Modern Ginseng formulas have also been used in conjunction with western medical approaches to treating patients with HIV, and patients undergoing chemo and radiotherapy.
Asian Ginseng is considered a "big gun" and should not be indiscriminately used especially by itself. Headache, elevated body temperature, digestive upset, rash, fever, irritability, and insomnia are possible signs that Ginseng is not appropriate. It should not be taken at the same time as caffeine or other stimulants. Good quality Ginseng is expensive. Superior grade Ginseng can run several thousand dollars per pound. For this reason, it makes no sense to shop for the cheapest Ginseng or Ginseng products.
Cancer fighter is found in broccoli
June 14, 2005 06:09 PM
Cancer fighter is found in broccoli
WASHINGTON (AP) - Remember when your mother told you to eat broccoli? Scientists say they've proved mother knows best.
Dr. Paul Talalay of Johns Hopkins University School of Medicine said in a paper published today that studies in his lab show broccoli is rich in sulforaphane, a chemical that works as a powerful anti-cancer compound in laboratory mice. Studies have shown that a diet rich in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower, can lower the risk of cancer of the bowel, stomach and breast. How those vegetables caused the effect wasn't clear.
Now, Dr. Talalay said, it appears that at least one anti-cancer ingredient in the vegetables is sulforaphane. It works by causing cells to expel cancer-causing toxins. He said this is the first time a high-potency compound has been isolated from vegetables and has been shown to accelerate the detoxification process in cells. Dr. Talalay said his team isolated sulforaphane from broccoli, then fed it to a group of mice. When cells in the mice were examined after five days, the scientists found that the chemical had triggered enzymes known to neutralize carcinogens within cells. Research, Dr. Talalay said, will shift to the long-term cancer-fighting effects of the chemical. "Our prediction is that sulforaphane will block tumor formation in animals and presumably in man," he said. Nutrition and medical scientists are trying to find ways to prevent cancer through a diet rich in foods that have anti-tumor properties.
In earlier studies, Dr.Talalay said, he and others have shown that certain proteins in cells, called Phase I enzymes, can take innocent chemicals and turn them into carcinogens, or compounds that can give rise to cancer by disrupting the genetic pattern in cells. Other proteins, called Phase 2 enzymes, he said, tend to block formation of carcinogens. Sulforaphane, he said, is a potent activator of Phase 2 enzymes. "There is mounting evidence that if you are able to raise the Phase 2 enzymes, this will divert the carcinogenic compounds from damaging the [genes]," Dr. Talalay said. "By tilting this balance toward Phase 2 enzymes, we can achieve protection from cancer." The Hopkins researchers will conduct tests to determine how much broccoli must be consumed to establish an effective anti-cancer level of sulforaphane in cells. Over a decade of research has been done on cruciferous vegetables and there are large databases that confirm that cruciferous vegetables substantially reduce the risk of disease, specifically cancer. Studies show substances in these vegetables that have anti-cancer properties which cause the body to speed up production of enzymes, therefore being capable of neutralizing cancer agents. The studies also show these prevent damage to our DNA and slow the aging process. In women, metabolic processes are regulated which eliminate the bad (and maintain the good) estrogen, therefore substantially reduce the risk of breast cancer. Shortly after the NCI study was released, John Hopkins School of Medicine revealed similar studies.
Due to these study results, the National Cancer Institute, the American Cancer Society, the National Academy of Sciences, the U.S. Department of Agriculture, John Hopkins School of Medicine and the FDA have all reached out to inform the public of the anti-cancer compounds found in cruciferous vegetables, and are advocating the daily consumption of these vegetables. The average American has been eating only 4 and one half pounds of these vegetables per year!
Botanical Arsenal - Plants can help our bodies fight off cancer's deadly ...
June 13, 2005 10:31 AM
Botanical Arsenal by Fred Thomas Energy Times, May 3, 1999
The complexities surrounding the various types of cancer stem from the variety of ways in which these diseases can wreak their havoc. Luckily, the equally complex world of plants contains novel compounds that can help our bodies fight off cancer's deadly progress.
Research into these botanical compounds is mushrooming. An example: The mighty maitake, a fungus with flair, alternately known as the king (it can grow as large as a basketball, worth its weight in silver to the ancient Japanese); the prince; the Hen of the Woods (it sticks out of from trees when it grows in the wild); and the dancing mushroom to those who leaped for joy when they found one growing in its native northeastern Japan.
Researchers today dub it with a new moniker: Herbal Heavyweight.
Mushroom with Potential
The maitake, with such other medicinal mushrooms as shiitake and reishi, historically has been eaten to promote general well-being and vitality. In the modern lab, however, scientists focus on the potent immune enhancing powers of maitake, which spotlight its cancer fighting potential.
Twenty years ago, maitake, Grifola frondosa, was an obscure, largely unavailable mushroom. A series of significant Japanese studies then catapulted it into prominence-and popularity.
Hiroaki Nanba, PhD, of the department of immunology at Kobe Women's College of Pharmacy on Kobe, Japan, and a leading international researcher on maitake, conducted the preliminary tests on the mushroom, demonstrating that it stimulates immune function and inhibits tumor growth.
In 1986, Dr. Nanba fed powdered maitake to mice injected with tumor cells; 86.3% displayed inhibited tumor growth.
Dr. Nanba and his colleagues went on to run additional mouse tests, finally reporting that this potent mushroom "directly activates various effector cells (macrophages, natural killer cells, killer T-cells, etc.) to attack tumor cells."
From then, maitake mushrooms were headed to fame as cancer ninjas.
Stoking The Immune Engine
Like other mushrooms, maitake is rich in complex polysaccharides, immunomodulators that successive tests after Dr. Nanba's have shown to be effective in cancer and AIDS treatment.
The polysaccharides in maitake have a unique structure, rendering them some of the most powerful to be studied (Chem Pharm Bull 1987:35:1162-8).
What makes maitake a particularly hot property is beta-D-glucan, its primary polysaccharide. Studies show that the body absorbs it readily, at which point it effectively stimulates interleukin-1, natural killer cells and macrophages, anti-tumor warriors that battle solid cancers (Chemotherapy 1990;38:790-6; also International Conference on AIDS, Amsterdam, 1992).
Effective And Safe
In addition to lab tests, trials on people have shown that maitake may offer powerful therapy against liver and stomach cancer (studies in China), breast and colon cancer (US research) and Kaposi's Sarcoma, the virulent cancer attacking AIDS sufferers.
Importantly, studies show that no side effects or interactions accompany maitake's efficacy.
Maitake fortunately has won the interest and enthusiasm of the scientific community. Currently, researchers at the Cancer Treatment Centers of America, headed by Denis Miller, MD, are completing an exhaustive test of the anticancer and immunostimulatory actions of maitake on folks with advanced colorectal cancer. These investigators hypothesize that the polysaccharide beta-glucans derived from the fruitbody of maitake fight tumors and boost immune function. "Though it cannot be said that maitake ...[is] the cancer cure," said Dr. Nanba in his closing remarks at the Adjuvant Nutrition in Cancer Treatment Symposium in Tampa, Florida, in October 1995, "one can safely say that they do maintain the quality of life of patients and improve the immune system, resulting in the possible remission of cancer cells with no side effects."
More Bodily Benefits
Maitake maven Dr. Nanba also has tested-with strongly positive results-the effect of maitake on blood glucose, insulin and triglycerides in mice, whose levels of all three substances declined when they were fed the mushroom (H. Nanba working paper, Anti-Diabetic Activity by Maitake Mushroom, 1994).
With colleagues, Dr. Nanba showed that maitake lowered blood pressure in hypertensive rats (Chem. Phann. Bu//36:1000-1006,1988). Other studies suggest it may accelerate weight loss.
This admirable adaptogen (meaning it helps the body adapt to stress and normalize its functions) is water soluble and may be eaten in food or taken as a supplement. Vitamin C is believed to intensify maitake's beta-glucans and enhance their absorption.
It's not just what you eat that may help protect against cancer, but what you drink as well. Research from China and Japan, where tea is the everyday drink and rates of several cancers like breast and prostate are lower, may persuade you to turn over a new leaf in your own beverage choice. One of the first studies to spark interest in tea came from Shanghai (Journal of the National Cancer Institute, June 1, 1994), where people who drank two to three cups a day were found to have about a 60% reduction in the risk of cancer of the esophagus. The reason: tea leaves contain compounds called polyphenols, potent antioxidants.
In fact, in tests at the University of Kansas, three of these, known as catechins, far outshone the common antioxidant vitamins C and E. Clinical trials are just starting, but early results are encouraging. A team of Chinese scientists reported that in a third of people with precancerous mouth sores who drank three cups of a mixture of green and black tea the lesions shrank significantly.
Researchers at the Saitama Cancer Center in Japan found that green tea seems to improve the prognosis of breast cancer. They followed a group of women with early-stage tumors for seven years. Those who drank more than five cups of green tea a day were only half as likely to suffer a recurrence as patients who consumed fewer than four cups a day.
And at the University of Indiana, toxicologist James Klaunig found that the lungs of cigarette smokers who drank the equivalent of six cups of tea a day suffered 40 to 50 percent less damage from the toxins in smoke, potentially lowering their risk of lung cancer and other pulmonary problems. Simultaneously, research from Purdue University suggests tea's cancer-discouraging powers go beyond being an antioxidant. Scientists Dorothy and D. James Morre showed that a tea catechin dubbed EGCG inhibits a growth-promoting enzyme on the surface of many cancer cells-happily without affecting normal cells. And researchers at the Ohio State University College of Medicine found that EGCG counteracted another enzyme, urokinase, that helps cancer cells spread. To top it off, Mayo Clinic scientists recently showed that EGCG prompted prostate cancer cells to commit suicide (Cancer Letters, Aug. 14, 1998).
So far, most tea research has focused on green tea, and investigators agree it's more potent than the black tea most Americans favor. But because both kinds come from the same plant, Camellia sinensis (it's the processing that makes the difference as black tea is fermented, green tea isn't) both contain cancer-fighting polyphenols, just in different quantities. As long as the tea you drink (even decaffeinated) is fresh brewed, it's likely to provide some benefit; powdered and prepared teas probably don't. And adding milk may dilute the effect.
Astragalus Against Tumors
Astragalus, an herb commonly used in Asia to boost stamina, has impressed western doctors for its potential for helping people cope with chemotherapy. As John Diamon, MD, W. Lee Cowden, MD and Burton Goldberg point out in the Definitive Guide to Cancer (Future Medicine), "Astragalus appears to protect the liver against the harmful toxic effects of chemotherapy and may be effective in treating terminally ill liver cancer patients." (They cite a study in the Jrnl of Ethnopharmacology 1990, 30:145-149.) In addition, they point out, research in Japan supports using a ginseng-astragalus combination to improve the function of natural killer (NK) cells which can boost immunity (Japanese Jrnl of Allergy, 37:2, 1998, 107-114).
Other studies confirm astragalus' potential in fighting off cancer. Research at the General Hospital of PLA, Beijing, showed that flavonoids (pigments) in astragalus could help protect cell membranes from oxidative damage caused by ultraviolet exposure (Chung Kuo Chung Yao Tsa Chih, 21(12):746-8; 1996 Dec).
A study of laboratory animals at Cunma University in Maebashi, Japan, found that Astragalus could help preserve immune function against the harmful side effects of chemotherapy (Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 15(2):101-3, 1995 Feb).
Like a flame attracting moths, garlic bulbs have irresistibly drawn the attention of medical researchers. A study at Aarhus University, Denmark, found that skin cells in laboratory dishes treated with garlic supplements lived longer, healthier lives than untreated cells (Jrnl Ethnopharm, 1994. 43:125-133).
Meanwhile, a long list of research demonstrates that garlic's phytochemicals may fight tumors and reduce the carcinogenicity of the pollutants and chemicals that assault us daily. A study in China reported in the American Journal of Chinese Medicine showed that garlic helped slow tumors in lab animals (1983, 11:69-73). Another study in the Journal of Nutrition found that compounds in garlic could "suppress the growth of human colon tumor cells" (126, 1355-1361).
Added to those benefits, Robert A. Nagourney, MD, reports in the Journal of Medicinal Food (1:1, 1998, 13-28), garlic may "modify the carcinogenicity of foodstuffs." In other words, studies show that garlic can make chemicals in foods like pork less likely to cause your cells to become cancerous. (Ind J Physiol Pharmacol, 39:347-353).
DNA, the stuff that genes are made of, face constant threats from free radicals, caustic molecules that can alter cellular structure and possibly cause genetic mutations that lead to cancer. But research into what are called oligomeric proanthocyanidins (OPC), flavonoids (pigments) derived from fruits vegetables, grape seed extract and the bark of maritime pine trees shows that OPC may be able to shield DNA from injury.
In particular, studies of a grape seed extract called Activin have demonstrated this substance can help liver cell DNA escape a destructive process called peroxidation (FASEB, 11:3, 2/28/97).
In these experiments, Activin demonstrated the ability to inhibit the growth of tumor cells as well as slow the replication enzymes of HIV viruses. This protective ability proved to be more potent than that of vitamin C, beta carotene and vitamin E.
What does the future promise to reveal? Scientists believe that many unexamined plants probably contain undiscovered phytochemicals that hold great potential for helping us fight the cancer epidemic.
Certainly, if the next few years produce as many results as the past decade, the next millennium will witness a long line of cancer-prevention discoveries. Before long, you should be able to take advantage of these potent substances.
As you gulp your garlic, tip your tea cup, mull your maitake, acquire Activin and await your astragalus, you may meditate on what may soon be added to our growing anti-cancer arsenal. Undoubtedly, scientists with a botanical bent will be uncovering more coveted anti-cancer secrets before too long.
June 10, 2005 10:16 PM
Mushrooms by Frank Sturges Energy Times, December 7, 1999
The interest in mushrooms as health enhancers has... mushroomed. Mushrooms, researchers have found, are filled with a long list of substances that may help us fight disease. Some of these natural chemicals boost immunity. Others may be effective against cancer and heart disease.
One of the most remarkable aspects of the research into mushrooms stems from the vast number of mushrooms that dot the landscape. At least 1.5 million types of fungi populate forests, fields, nooks and crannies, but studies have detailed the properties of less than 3,000.
Mushrooms produce so many beneficial compounds because they constantly fight off other fungi and microbes to survive. These substances, which mushrooms utilize for defense, can apparently help humans.
One of the most important of these classes of compounds are the polysaccharides. Scientists believe these long starch molecules spark immune action that can protect us against invading germs or cancer. They may do this by persuading the body to create what are called killer T-cells. These immune warriors destroy microscopic invaders and may help stop tumors.
According to Paul Stamets, author of Growing Gourmet and Medicinal Mushrooms (Ten Speed), use of polysaccharides... "will synergistically, in combination with the individual's immune system, result in dramatic recoveries...Right now we don't clearly understand all the elements in those formulas to be able to predict downstream what will happen. But clearly with some people, it is tremendously effective" (Townsend Ltr, 6/98).
In addition, mushrooms also make biologically active chemicals called steroids and terpenes, says Christopher Hobbs, author of Medicinal Mushrooms (Interweave). These substances are thought to help fight off the formation of cancerous tumors.
Maitake: Useful Fungus
Maitake (Grifola frondosa) mushrooms, also known as "Hen of the woods," contain chemicals called beta glucans that can enhance immunity. Scientists are particularly fascinated by substances called the "D-fraction." Studies show these can spur immunity (Biol. Pharm. Bull. 17(12), Dec. 1994: 1554-60).
Researchers are also looking into the possibility that Maitake can help people with AIDS regain weight. And scientists are examining their effect on high blood pressure and diabetes.
In Tibet, the Reishi mushroom (Ganoderma lucidum) has long been used to battle altitude sickness in the Himalayan mountains. Reishi is also reputed to soothe frayed nerves.
Scientific studies have supported these traditional uses, finding that people who consumed Reishi functioned better in low oxygen (Proceedings Contrib Symp 59 AB, 5th Intl Cong, 8/14-21, 101-104). Other research finds Reishi may help ease arthritis (Proc 1st Intl Symp on Ganoderma l. 11/17-18, 99-103, Tokyo).
Lion's Mane (Heri-cium erinaceus), also called "Monkey's head," has traditionally been a treatment for stomach problems in China. But researchers have found that chemicals in this mushroom help fight tumors (Biosci Biotech Biochem 56(2), Feb. 1992: 347-8).
During the past few years, scientific investigators have also begun to extract chemicals called erinacines from lion's mane. These substances, (known as Nerve Growth Stimulant factor) appear to encourage neuron regeneration. The potential uses: boosting nerve performance, fixing neurological damage and treating Alzheimer's disease (Tetrahedron Ltrs 35(10), 1994: 1569-1572).
Known as Cogmelo de Deus (Mushroom of God) in Brazil, the Royal Agaricus (Agaricus blazei) has been grown in Japan since the '70s where it enjoys widespread popularity. Researchers find that it provokes powerful anti-tumor effects. This fungus harbors more beta-glucans, immunity enhancers, than other mushrooms.
Can a fungus make athletes faster? A few researchers think so, pointing to Chinese Olympians who use Cordyceps sinensis. This fungus, traditionally grown on caterpillars, is another native of the Himalayas.
Traditionally, Cordyceps has been used to foster stamina, better breathing and immunity.
At least one study shows this fungus may help blood vessels dilate during exercise. By supplying extra blood to working muscles, Cordyceps may help fight off fatigue and boost performance (Abstracts from 5th Mycological Cong, Vancouver, 8/14-21).
The mushroom called Shiitake has been the subject of an extravagant amount of research since the '60s. Called the "elixir of life," it boosts immunity. Stamets reports that people with cancer who take Shiitake do significantly better in coping with their disease (Abstract 2nd Meeting Soc of Natl Immunity, Italy, 5/25/94).
Another characteristic of Shiitake mushrooms: a celebrated taste. The tongue and the palate take great pleasure in this health enhancer!
Largest Human Clinical Study Confirms Aged Garlic Extract's Ability to Reduce Cancer Risk
June 09, 2005 05:26 PM
Largest Human Clinical Study Confirms Aged Garlic Extract's Ability to Reduce Cancer Risk Factors Presented at the 2005 World Garlic Symposium at Georgetown
Garlic has been used medicinally for thousands of years. Past research has established the significance of garlic and its healthful benefits. Recently new metabolic roles for garlic were presented at the symposium, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease” which was held at the Georgetown University Conference Center on April 9-11, 2005.
The conference brought together the world’s top authorities in various fields of garlic research to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states such as cancer.
One of the highlight presentations was on the biggest study ever conducted in the history of garlic supplementation, a 7 year long clinical study. The study was undertaken to determine aged garlic extract effects on stomach cancer and serous digestive problems that can lead to gastric cancers. It was performed through collaboration of National Cancer Institute (NCI) and leading Chinese researchers, who tested to see if aged garlic supplementation would significantly effect or reduce precancerous gastric lesions. The clinical study was double-blinded and randomized, with over 3,000 human subjects. It was led by Dr. Mitchell Gail at NCI and Dr. Wei-Cheng You at the Beijing Institute for Cancer Research.
Preliminary results of this study showed that people with the highest intake of allium-containing vegetables, like aged garlic, had only 40% of the risk of gastric cancers as those who rarely ate them.
Also from the Chinese study was another surprising finding: when researchers used aged garlic extract in combination with antibiotics to treat people with precancerous stomach lesions caused by the Helicobacter pylori bacteria, 76% were completely healed. “It’s a very large and long-term study. We’re still sifting though the data, but we expect to report on it by the end of this year,” said Dr. Gail.
Another surprising presentation showed the results of several colon cancer studies reported from both Osaka and Hiroshima University in Japan. These studies clearly showed that the addition of aged garlic extract to cancer treatment was beneficial to colon cancer patients. Researchers found that those who consumed aged garlic extract experienced a reduction of the size and prevalence of tumors.
“Aged garlic extract has well-known antioxidant properties. The aging process eliminates garlic breath as well as those harmful properties, leaving only the antioxidants that protect against disease,” said cancer symposium chairperson and lead UCLA researcher David Heber, M.D.
Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects.
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
June 09, 2005 05:22 PM
The Latest Breakthroughs in Garlic Research
on Cancer and Cardiovascular Disease
Presented at the 2005 World Garlic Symposium
Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005.
“For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.”
Presentation highlights included:
Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.
“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.”
Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. .
PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892
Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders.
INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA
Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events.
INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany
Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.
David Heber, MD, PhD, FACP, FACN
Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center
Matthew Budoff, MD, FACC
Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.