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Understanding Benfotiamine: The Fat-Soluble, Bioavailable and Physiologically Active Form of Thiamine Darrell Miller 7/27/23
5 Important Minerals and Vitamins all Crossfitters Need to beEating VitaNet, LLC Staff 11/10/18
6 Natural Remedies To Cleanse Your Congested Colon Darrell Miller 2/10/18
Bayberry Bark & Sinus Infections Darrell Miller 4/15/14
Supplements That Can Improve Focus Darrell Miller 3/23/14
What Are The Health Benefits Of Borage Seed Oil? Darrell Miller 12/29/13
Maitake Mushrooms - Eating your Way to Health Darrell Miller 10/25/13
Preventive Measures for Metabolic Syndrome/ Diabetes Darrell Miller 2/10/12
Boost Your Blood Health with Blood Blend Darrell Miller 11/24/11
The Krebs Cycle - Our Lifes Blood! Darrell Miller 1/13/11
Pantothenic acid has a wide range of health benefits Darrell Miller 12/28/10
You can protect your liver and more with Milk thistle Extract Darrell Miller 12/23/10
Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination Darrell Miller 3/22/10
L-Methionine Darrell Miller 5/2/09
Vitamins Herbs And Antioxidants Darrell Miller 10/17/08
GrapeSeed Extract Darrell Miller 10/15/08
Colon Cleanse And Enema Darrell Miller 9/8/08
Gac Fruit Oil Darrell Miller 8/25/08
B Vitamin Complex Darrell Miller 6/23/08
Increase Absorption Of Your Discount Vitamins With Bioperine Darrell Miller 11/2/07
Build Healthier Skin With Antioxidant Rich Skin Moisturizing Lotions Darrell Miller 11/2/07
Do you experience muscle pain and inflammation? Darrell Miller 4/25/07
Taming the Tingle – ALA helps fight nerve damage caused by diabetes…and more. Darrell Miller 11/9/06
Benefits of Best Alpha Lipoic 35! Darrell Miller 2/12/06
Benefits of Acetyl-L-Carnitine Darrell Miller 2/12/06
The Free Radical Theory Darrell Miller 12/14/05
Benefits of Alpha Lipoic Acid Darrell Miller 10/13/05
Re: Magnesium Darrell Miller 10/6/05
Curcumin - Turmeric Extract Darrell Miller 8/19/05
ENADA® NADH 5mg - NEW PRODUCT ANNOUNCEMENT Darrell Miller 8/3/05
Benfotiamine raises the blood level of thiamine pyrophosphate (TPP) Darrell Miller 8/2/05
VANADIUM W/CHROMIUM - Supports Healthy Blood Sugar Levels Darrell Miller 6/24/05
What is the difference between the types of Ginseng? Darrell Miller 6/17/05
Ocean Treasures - For centuries, people have flocked to the sea.... Darrell Miller 6/13/05
Health Movements - Joining mind and body with healthy movement generates harmony Darrell Miller 6/12/05
The Joints Are Jumping Darrell Miller 6/11/05
Stevia, Xylitol Sugar alternatives ... Darrell Miller 6/9/05
Skin Eternal - Replenish Your Skin Darrell Miller 6/6/05
SAMe - Supports Joint Comfort, Function and Mobility ... Darrell Miller 6/6/05
Mega H- Hydrogen (H-)The Fuel of Life Darrell Miller 6/3/05
HEART RESPONSE - Comprehensive Support for a Healthy Heart! Darrell Miller 6/2/05
GlucosaMend™ Tissue/Joint Repair Complex Darrell Miller 6/2/05
Fibro Response - Feel your Vitality ... Darrell Miller 6/2/05
COENZYME Q10 - Transforming food into energy Darrell Miller 6/1/05
Cholestrex - Lower Cholesterol with Source Naturals Supplements Darrell Miller 6/1/05
Re: Acetyl-L-Carnitine - Anti-Aging Brain Nutrient ... Darrell Miller 5/31/05
Composition and Method of increasing Testonsterone... Darrell Miller 5/17/05




Understanding Benfotiamine: The Fat-Soluble, Bioavailable and Physiologically Active Form of Thiamine
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Date: July 27, 2023 12:12 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Understanding Benfotiamine: The Fat-Soluble, Bioavailable and Physiologically Active Form of Thiamine

What if there existed a form of thiamine that was more bioavailable and physiologically active than the conventional form we all know about? Well, that form does exist, and it is called Benfotiamine. Benfotiamine has been gaining popularity lately, especially among people dealing with diabetes and other metabolic disorders. But what exactly is Benfotiamine, and what makes it different? Lets explore Benfotiamine, its bioavailability, and its physiological effects.

Thiamine, also known as Vitamin B1, is a nutrient that plays a crucial role in energy production, nerve function, and metabolism. It is a water-soluble vitamin, which means it dissolves in water and is not stored by the body. However, conventional forms of thiamine have a limited ability to cross cell membranes and are easily excreted out of the body, rendering it ineffective for some individuals. This is where Benfotiamine comes in; it is a modified form of Vitamin B1 that is fat-soluble, highly bioavailable, and because cells are wrapped in lipid fat this form of B1 is capable of crossing cell membranes with ease.

Since our cell membranes are composed of lipids, fat-soluble nutrients can easily penetrate the cell barrier and get into living cells where the vitamin is needed. Upon entering the bloodstream, benfotiamine is converted to thiamin pyrophosphate (TPP), the biologically active co-enzyme of thiamin, which is responsible for energy metabolism. By raising the blood levels of TPP, benfotiamine has been shown to support glucose metabolism, reduce oxidative stress and inflammation, and protect against the damage caused by high levels of advanced glycation end products (AGEs).

In addition to its bioavailability, benfotiamine has been shown to have several physiological effect on the body. One of the key enzymes that benfotiamine influences is transketolase, which is involved in the pentose phosphate pathway, a metabolic pathway that generates NADPH, a vital molecule that protects cells against oxidative stress. By stimulating transketolase, benfotiamine supports the diversion of excess glucose to the pentose phosphate pathway, thereby reducing the production of reactive oxygen species and increasing the production of NADPH.

Another significant benefit of benfotiamine is that it helps protect the nervous system. Chronic high blood glucose levels are known to cause oxidative stress and to damage the peripheral and central nervous systems. However, benfotiamine has been shown to help lower oxidative stress markers and reduce the risk of nerve damage. This can in turn help reduce pain, numbness, and tingling sensations associated with nerve damage, making it a promising adjunct therapy for people with diabetic neuropathy.

In Summary: benfotiamine is a modified and bioavailable form of thiamine that offers unique benefits compared to conventional forms of Vitamin B1. Its fat-solubility enables it to cross cell membranes, raise levels of thiamin pyrophosphate, stimulate the transketolase enzyme, and support proper glucose metabolism. Its notable effects on the nervous system make it an attractive therapeutic agent for people with diabetic neuropathy. If you're seeking an alternative and highly effective form of thiamine, benfotiamine is definitely worth considering. Give it a try today!

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5 Important Minerals and Vitamins all Crossfitters Need to beEating
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Date: November 10, 2018 09:51 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: 5 Important Minerals and Vitamins all Crossfitters Need to beEating





If you are someone who exercises a lot, or participates in CrossFit, then you must know how important your diet is. Too many people disregard their diet and do not think anything of it long term. It is something that can really affect the way that people live their life for a variety of different reasons. You are the only one who controls what goes into your bodies. Therefore, these minerals and vitamins are so important for active individuals.

Key Takeaways:

  • Your body is like a car in that you need to fuel it with the right stuff for it to function properly.
  • Understanding how to have minerals and vitamins incorporated into your diet can be really useful.
  • If you are someone that does crossfit, you must understand that diet is so important to maintaining your strength.

"Vitamin C helps to strengthen the immune system, assist the rate at which we can absorb iron and is an important antioxidant that regenerates other antioxidants within the body."

Read more: https://www.boxrox.com/minerals-vitamins-crossfitters-need-to-be-eating/

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6 Natural Remedies To Cleanse Your Congested Colon
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Date: February 10, 2018 03:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: 6 Natural Remedies To Cleanse Your Congested Colon





The colon is part of the digestive system whose function is to assimilate the nutrients of food, however, due to poor eating habits, this organ houses a large amount of toxic material that eventually wears it and generates health consequences; In this sense it is very important to consider healthy practices to improve the functioning and restore the health of this vital organ, such as drinking between 10 and 12 glasses of water and if it has a high level of alkalinity, excellent; the consumption of seeds of linanza provides a high content of fiber and omega3, the juice of lemon contributes with its detoxification and the consumption of plums helps its mobility. Finally these simple habits, can improve the health and life of your colon .

Key Takeaways:

  • The colon is one of the most important organs in the body, tasked with regulating digestion and absorbing nutrients.
  • However, many people do not take appropriate levels of take for their colon, allowing high level of toxins and waste to build up.
  • However, there are easy, natural steps that everyone can take to help improve colon health.

"It just so happens that one of the most effective ways to cleanse and detoxify your colon is also one of the easiest: drink more water!"

Read more: https://www.thealternativedaily.com/6-natural-remedies-cleanse-congested-colon/

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Bayberry Bark & Sinus Infections
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Date: April 15, 2014 10:22 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Bayberry Bark & Sinus Infections

bayberry barkSinus depression

The sinus depression is spotted behind the eyes and nose and is a substantial void space that channels the air for the lungs. At the point when the sinus hole gets aggravated or excited, it can without much of a stretch transform into a sinus contamination. A sinus contamination causes the sinuses to swell and produce abundance bodily fluid, making serious clogging, torment all around the head and neck and sinus weight. A sinus disease can commonly be dealt with effortlessly with either pills or regular cures.

Benefits of bayberry bark

Bayberry bark is a compelling approach to help treat the signs and manifestations of a sinus disease. The herb empowers the circulatory framework, supporting the body in dislodging abundance bodily fluid from the sinus depression. Bayberry bark additionally generates a warming sensation, which will help relax thick bodily fluid development.

Properties of  bayberry

Bayberry bark hold a certain synthetic called myricitrin, which is a regular anti-microbial. Not all like pill anti-toxins, has myricitrin just executed off destructive micro organisms. Drug anti-infection agents murder all microbes in the body, which can prompt different complexities, for example, a safety to anti-microbials, the runs and even the spread of the contamination. Myricitrin likewise regularly decreases fever and clears nasal blockage while executing the contamination creating the sinusitis.

Dosing of bayberry

Bayberry bark might be utilized to treat a sinus disease as either an oral or topical result. Oral utilization ought to be a half teaspoon, twice every day. In the event that the manifestations stay following 24 hours, a singular can expand the measurements to one teaspoon, twice every day. As a topical result, the bayberry bark could be blended with back rub oil and connected to the paranasal territory of the face. A light rub will help release bodily fluid and calm sinus weight.

Caution in using bayberry

There are potential symptoms when utilizing bayberry bark. For some individuals it has brought about unsteadiness, queasiness and spewing. It has likewise brought on gastrointestinal issues in individuals with previous gastrointestinal conditions. On the off chance that a sinus contamination continues for a week, a singular ought to see a specialist to focus the best technique for treating the diseases.

 

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Supplements That Can Improve Focus
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Date: March 23, 2014 07:57 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Supplements That Can Improve Focus

bacopa plantAbout focus

A focused mind is one that is able to concentrate on a particular issue and think about it, discuss it or deal with it and pay special attention to that subject. This explains why people have different focus abilities as brought about by their varying environments and capabilities. Enhanced minds quickly grasp ideas as opposed to low minded ones. A determined mind therefore understands and interpret facts more readily in an effective way, and this is why it is important for individuals to to be focused at school. However, there are instances where learners have limited focus abilities, but this can be improved by use of focus supplements. The following are the supplements that can be used to boost an individual's focus levels.

Supplement that can help improve focus

Phosphatidyl Serine improves the mood and short term memory of an individual, thereby enhancing retention of a human's mind. This supplement lowers the chances of cognitive dysfunction development. It contains cellulose, magnesium stearate, cellulose capsule and silica, as the main ingredients. The capsule dosage can be taken three times every day.

DMAE is also known as dimethylethanolamine and it increase acetylcholine levels which is a vital neurotransmitter of the brain. This helps to reduce the neuronal excitation in calming the under firing, to generate an average calming impact in the mind, thereby boosting focus levels.

L-Tyrosine is another supplement that can be used to improve a person's focus abilities. This is associated with generating amino acids that are responsible for enhancement of drive, motivation and alertness in the body. Acetyl-l-tyrosine is an ingredient that helps to maintain cognitive duty while in distress. Tyrosine crosses the blood brain barrier, hence making it an outstanding nutrient for the health of the brain. Tyrosine also generates a hormone called thyroid, that increases focus.

Bacopa is a persistent creeping herb supplement that has been used for a long time to improve memory, and generally cognitive performance. It contains ingredients that reduces oxidation stress, namely; polyphenol and sulfhydryl compounds. The recommended dosage is 150 mg of bacopa every day.

Sources

  1. //www.livestrong.com/article/403466-the-best-supplements-to-help-you-focus/
  2. //www.wellnessresources.com/supplements/super-brain-booster.php?utm_campaign=8557&utm_term=supplements%20that%20can%20help%20with%20focus&utm_medium=microsoft&utm_source=trada&keyword=supplements%20that%20can%20help%20with%20focus&utm_nooverride=1&utm_content=3036132661

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What Are The Health Benefits Of Borage Seed Oil?
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Date: December 29, 2013 05:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Are The Health Benefits Of Borage Seed Oil?

What is Borage

borageThe borage also known as starflower plant generates seeds enriched with essential fatty acid known as Gamma-linolenic acid. In ancient times, borage plant was mainly used to prepare salad and soups due to its relaxing effect on people. However, in modern times people are more interested in borage seeds. This is due to its health benefits offered by gamma-linolenci acid (GLA). GLA has anti-inflammatory effects useful to both men and women. Borage oil comprises about 24% of GLA which is the highest known energy for naturally occurring GLA. After consumption, much of the GLA found in borage oil turns into dihomo-gamma-linolenic acid. GLA and DGLA prevent inflammation just like omega-3-fatty acids from fish oil or flaxseed. However, GLA and DGLA are categorized as omega-6-fatty acids.

Benefits of Borage

According to recent studies, Borage oil can be used to treat rheumatoid arthritis. This is an autoimmune ailment which results to joint lining inflammation. Rheumatoid arthritis is a chronic and painful ailment that requires use of non-steroidal anti-inflammatory medications, such as, NSAIDS that can have side effects. Borage oil is used to reduce tenderness and swelling for rheumatoid arthritis patients.

Borage oil is used to soothe and moisturize dry skin and treats inflamed skin diseases. It also tones dry skin, prevents wrinkles and dehydration. Borage oil provides fantastic regenerative and firming properties that help to restore skin elasticity.

Borage oil helps in boosting immune system and is an essential part of the human breast milk. When infants breastfeed they can significantly avoid risk of developing allergies.

Borage oil also treats premenstrual syndrome and cramps, diabetic neurotherapy as well as other inflammatory ailments. The oil is normally taken internally as a capsule or can be applied topically.

Warning of Borage

If you plan to use borage oil for treating any health problem, ensure that you consult your doctor before you begin using your supplement treatment.

Reference:

  1. //www.ehow.com/about_5086939_borage-seed-oil-benefits.html


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Maitake Mushrooms - Eating your Way to Health
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Date: October 25, 2013 07:36 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Maitake Mushrooms - Eating your Way to Health

maitake

In a world full of processed drugs and foods, the possibilities of getting a viable natural remedy for an ailment have decreased exponentially. As the society as a whole becomes more concerned with the safety and nutritional value of the foods they eat, the need for a food that kills more than two birds with a single stone is one that cannot be outdueled. Currently, one of the best foods of choice out there is the Maitake mushroom.

Where is maitake mushroom came from

The Maitake is an edible mushroom native to the northeastern Japan Mountains. This mushroom contains the maitake D-fraction, a compound that exists in our bodies in a form referred to as beta-glucan. Since this component plays a vital role in maintaining the body’s homeostatic levels and hindering the development of some detrimental medical conditions, increasing its concentrations in our bodies increases our chances of living a longer and healthier life.

Components of maitake

Research has proven that the active component in the Maitake mushroom inhibits the growth of cancerous cells. It also boosts our immune system by stimulating the production of neutrophils, T-cells and white blood cells. This is achieved by the catalytic effect of the polysaccharide fibers it contains hence increasing the rate at which your immunity system regenerates and how strong it can stand in time of an infection.

Benefits of maitake mushroom

Other uses of the maitake extract include treating high blood sugar levels, combating hypertension, accelerating weight loss, lowering cholesterol levels in the body and supplying us with the trace elements our bodies need to function optimally.

Even though most of these research results are from tests that have not yet been rigorously verified on human beings to prove their effectiveness, there is nothing to be afraid of since eating this mushroom will leave you with no negative side effects.

Currently, we can reap of this mushroom’s healing and health boost powers by either directly eating it or by taking the maitake D-fraction as a dietary supplement. The last option is more viable to people who do not have access to the mushroom in its original form.

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Preventive Measures for Metabolic Syndrome/ Diabetes
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Date: February 10, 2012 07:55 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Preventive Measures for Metabolic Syndrome/ Diabetes

Metabolic syndrome is a serious health problem associated with cluster of conditions like high cholesterol level, high blood pressure, high sugar level and excessive fats in the abdomen. It increases risks of diabetes, heart attack and stroke. Having one of these conditions doesn't mean that you have metabolic syndrome. However, frequent occurrence of any of these symptoms can increase risk.

Knowing your family's medical history can prevent metabolic syndrome that can lead to diabetes. If it runs in the family, consult your doctor to have your blood sugar, cholesterol and blood pressure checked.

Avoid high carb diet to prevent metabolic syndrome and diabetes. During digestion, carbohydrate rich foods are broken down into sugar or glucose. Glucose gives energy to the body while calorie is the measure of burned energy. When high amount of carbohydrate is digested, it increases sugar level in the blood. The brain prompts the pancreas release insulin to neutralize blood sugar level. Diabetes happens when the body becomes resistant to insulin or when the pancreas does not produce enough insulin.

Replace high carb diet with more nutritious foods like oats, whole wheat, rye, red rice, sweet potatoes and buckwheat. They are energy giving food rich in dietary fibers. Fibers keep a healthy digestive system by improving digestion and eliminating body wastes. It maintains sexy abs by flushing out excess belly fats.

Stay physically active by engaging into sports and exercises. Inactive body does not use much energy. Unused energy is stored in the body in form of fats. Fat cells are resistant to insulin thus, increase blood sugar and cholesterol level. Fat cells slow down metabolism and increase weight gain. While lean muscles hastens metabolism even when the body is at rest. Lean muscle protects the body against insulin resistance.

Maintain a well balanced diet to reverse diabetes and metabolic syndrome. Raw fruits like oranges, berries, pineapple, grapes and other citrus fruits are good alternative for desserts like cakes. They are rich in Vitamin C that lowers cholesterol and burns fats. It is also rich in antioxidants that shield the body against harmful toxins.

Add green leafy vegetables to your diet to increase immunity from sickness like diabetes and metabolic syndrome. Green leafy vegetables are rich in Vitamin E that repairs and regenerates damaged cells.

Develop a healthy sleeping pattern. Sleep disturbances and staying up late at night prompt the pancreas to continually release insulin. This creates stress on the pancreas that leads to insufficient production of insulin. A well rested mind and body keep metabolic syndrome and diabetes away.

Try natural remedies like cinnamon, pine bark, and blueberry leaf extract. Cinnamon prevents diabetes and metabolic syndrome by lowering cholesterol and blood sugar level. Pine bark, when extracted produces pycnogenol that absorbs glucose in the blood. It also protects the eyes from blindness and blurred vision caused by diabetes. Blueberry leaf extract regulates blood sugar level by increasing the body's sensitivity to insulin.

Health supplements like chromium and alpha lipoic acid have shown great results in preventing and managing diabetes. Chromium is a mineral that metabolizes carbohydrates to prevent weight gain. It stabilizes blood sugar and prevents hypertension.

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Boost Your Blood Health with Blood Blend
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Date: November 24, 2011 11:30 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Boost Your Blood Health with Blood Blend

What Blood Blend Does For You

Blood Blend helps to keep your blood pure and free from toxins, while also maintaining a high hemoglobin count. Hemoglobin is responsible for carrying oxygen from your lungs to your body cells, enabling cellular respiration to take place. Without an adequate supply of oxygen your cells die, with a significant threat to life. Toxins are becoming increasingly more common in this modern industrial age, particularly prevalent in traffic and industrial emissions and also in tobacco fumes, modern pharmaceuticals and the pesticides and herbicides used in modern farming.

Without some means of helping your body to remove these toxins, your liver can become overwhelmed - it is not easy for it to handle alcohol metabolism, break down drugs such as Tylenol or paracetamol and also deal with toxins that enter your body through your lungs and skin. Toxins can easily pass into your bloodstream and then reach every part of your body. By taking Blood Blend, your blood will become more oxygenated and toxin-free, and your liver will be given a healthy boost in its detoxification properties. It is one supplement that you should take, particularly if you live in a city or are exposed to such toxins.

Taking Blood Blend to Prevent Anemia

Many people suffer anemia for one reason or another: perhaps they are recovering from illness or serious blood loss, and the condition is not uncommon in women with heavy menstrual periods. Some are anemic through a poor diet, and in some cases this can be a life-threatening condition. Blood Blend is designed to help reduce the effects of anemia by maintaining a healthy blood supply. This carefully balanced blend of herbal roots has been chosen for its detoxifying properties and its ability to improve your blood hemoglobin count. Not only that, but it is synergistic, meaning that the blend is more effective than the individual components separately.

Hemoglobin is a metalloprotein, containing iron, which forms the basis of the oxygen transport system in your blood. It is what makes oxygenated blood look bright red, and used blood look bluish-red and forms 97% of the dry weight of your red blood cells. Without a good, steady source of iron, your hemoglobin drops, ultimately leading to anemia. Blood Blend prevents this by providing a rich supply of iron. Oxygen is needed for the cellular respiration that generates ATP energy in each cell in your body, and without it your cells die, ultimately leading to gangrene. Hence, iron is needed for life.

Blood Blend not only provides this iron, but also the potassium that helps to maintain a healthy blood pressure. Too low a blood pressure is as dangerous as it being too high, and Blood Blend helps to keep this balanced. Add to that the blend's detoxification properties, and it is the perfect way to maintain a healthy, clean blood supply at a pressure sufficient to maintain a healthy circulation rate without overtaxing your heart.

Some Extra Properties of Blood Blend

Blood Blend is a powerful synergistic mixture of six herbs designed to maintain a healthy circulation of clean blood round your body, and a healthy liver that effectively detoxifies your blood. By taking a Blood Blend supplement, you will maintain a healthy level of hemoglobin in your blood as well as reducing the toxins absorbed through your skin, inhaled or taken unintentionally in your food. However, because of the nature of the six herbs used, the blend also offers other health benefits, not part of its primary function.

For example, echinacea not only purifies the blood and lymphatic system, but also supports the immune system, and is useful in reducing the symptoms and duration of colds and flu. It stimulates white cell production, and combats inflammation. Echinacea can be used to treat sore throats, bronchitis, sinus infections and even bacterial pneumonia. Sarsaparilla is both antibiotic and anti-inflammatory, while dandelion root is an excellent diuretic, improving the function of the liver and the kidneys. Licorice lowers LDL cholesterol levels, while yellow dock reduces inflammation of the bowel.

Like many herbal treatments, Blood Blend does what it says on the tin, but also offers many other ancillary health benefits that increase its value as an excellent maintenance supplement to take for general good health.

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The Krebs Cycle - Our Lifes Blood!
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Date: January 13, 2011 05:00 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Krebs Cycle - Our Lifes Blood!

The Krebs Cycle, also known as the Citric Acid Cycle, is an important series of biochemical reactions that are intrinsic to cellular respiration and the generation of energy from oxygen and glucose in aerobic organisms. Although humans can generate energy anaerobically, they cannot do so for long periods and oxygen is essential for life because it fuels the Krebs Cycle. Without this cycle, there would be no available energy to maintain our vital processes.

What is The Krebs Cycle

We shall first discuss exactly what the Krebs Cycle is and then its importance in the body. The process takes place within the mitochondria of the body cells.

A. The cycle begins with the ten-step pathway of glycolysis, during which glucose is converted to two molecules of pyruvate: no oxygen is required for this step. Basically:

Glucose + 2NAD+ + 2P + 2ADP = 2Pyruvate + 2NADH + 2H+ + 2ATP

The pyruvate can then undergo aerobic or anaerobic respiration to generate energy. The Krebs Cycle is the aerobic route, and significantly more efficient that the alternative fermentation.

B. The two pyruvate molecules are then oxidized to two of Acetyl CoA with the release of carbon dioxide. The two acetyl groups of the Acetyl CoA are donated to Oxaloacetate in the presence of water to form Citrate.

C. Citrate then undergoes a number of chemical reactions to arrive back at Oxaloacetate again and the cycle starts all over again by reacting with more Acetyl CoA from Pyruvate and oxygen to form Citrate again. During the cycle more ATP is produced and electrons and other species are sent into the Electron Transfer Chain where most energy is generated.

During this cycle three major events occur:

1. During the various transformations of Citrate, specifically when Succinyl-CoA is converted to Succinate, one Guanosine Triphosphate group (GTP) is generated, which then donates a phosphate to Adenosine Diphosphate (ADP) to create the energy molecule Adenosine Triphosphate (ATP).

2. Over the whole cycle, three molecules of Nicotinamide Adenine Dinucleotide (NAD) are reduced to NADH that donates its electrons to the electron transport chain that is responsible for the generation of large quantities of ATP.

3. A molecule of Flavine Adenosine Dinucleotide (FAD) is reduced to FADH2, again donating its electrons to the electron transport system and the generation of energy.

Factor 2 and 3 are of more significance to energy generation than factor 1, and are the major means by which the Krebs Cycle generates energy.

Electron Transport Chain

The Krebs Cycle takes place within the mitochondria, structures that are contained in each of your body cells. Also within these mitochondria are a series of membranes that are very important in the generation of energy.

The major energy produced in your body cells comes from the Electron Transport Chain, a series of chemical reactions between an electron donor and an electron acceptor. Such reactions drive the transport of hydrogen ions (H+) across the membranes in the mitochondria.

The electron donors are species such as NADH, FADH2 and succinate and the electron acceptors are oxygen molecules. Hence the importance of oxygen in the process of aerobic respiration. The H+ ions are driven across the membranes and result in the conversion of ADP to ATP energy. In essence, the hydrogen atoms and electrons take part in a progressive chain of redox reactions, and at the end react with oxygen molecules and change it to water.

The Ultimate Products

Ultimately, through the whole chain and cycles of:

Glucose to pyruvate (glycolysis) Pyruvate to Acetyl CoA + CO2 (oxidation) Acetyl CoA to Citrate and the entire Krebs Cycle (reduction and oxidation) Krebs Cycle products to the Electron Transfer Chain Electron Transfer Chain to Water and ATP (redox) Final oxidation of hydrogen atoms to water

Basically: Glucose + Oxygen + 30ADP = Carbon Dioxide + Water + 30ATP

This is not balanced of course, and the ATP could be anything from 29 to 38, though 29.85 is the most accurate calculation to date. The entire process of glycolysis, oxidation, Krebs Cycle and Electron Transport Chain is powered by a series of enzymes and a small amount of ATP energy.

Glucose and oxygen are used up as the raw materials and ATP energy molecules are the product. It has been calculated that the total ATP yield obtained from one molecule of glucose lies between 29.5 and 30 molecules of ATP.

The Importance of the Krebs Cycle to Your Body

Were it not for the Krebs Cycle you would not be able to generate energy efficiently from your food. In particular, the carbohydrate content of your food. Carbohydrates are available in your diet from two sources: simple and complex carbohydrate foodstuffs such as cereals and grains, and fats and oils from animal and vegetable sources. They are also available from proteins, which are composed of amino acids at the head of the molecule with a carbohydrate tail.

Carbohydrates by definition contain only carbon, hydrogen and oxygen molecules, and can be converted to glucose within your body. Proteins can be deaminated and then the carbohydrate portion again converted to glucose. In fact, your body will initially use the carbohydrates in your diet as a source of glucose for its glycolysis to pyruvate, then the fatty tissue in your body, then the proteins will be deaminated so your body can get to the carbohydrate they contain.

Were it not for the Krebs Cycle, your body could not use the glucose as described above to generate energy. The only option open to it would be anaerobic respiration, or energy production in the absence of oxygen. ATP is still generated, but much less efficiently.

Anaerobic Respiration

Anaerobic respiration is basically respiration without oxygen. If there was no Krebs Cycle, then this is the only way your body would have to create energy.

Because no oxygen is actually needed for glycolysis or the Krebs Cycle, anaerobic respiration can proceed right to the end of the Electron Transport Chain. Then instead of oxygen being used as the terminal electron donor, it has to be another species such as nitrate or sulfate. Because the Reduction Potential of these species is much lower than that of oxygen, the amount of ATP energy produced is also much lower.

Your body tries to compensate by producing even more pyruvate and the excess is removed through lactic acid fermentation. Although this also generates ATP energy enough for short-term use, it leads ultimately to lactic acidosis and a reduction in pH, causing pain and vomiting.

Ultimately, if oxygen is not forthcoming, the brain runs short of the energy needed for it to work and you die. There is insufficient ATP generated from anaerobic respiration to maintain human life.

Conclusion

The Krebs Cycle is of critical importance for the production of energy: not just the energy to enable you to run fast, but to enable your metabolic processes to continue. It is needed for both aerobic and anaerobic respiration, and while lactic acid fermentation can be used by your muscle cells as a brief but effective means of generating short-term energy, it is insufficient to maintain the needs of your metabolism.

Without the Krebs Cycle, mammalian and most other animal life would not be viable and the world would be populated by anaerobic bacteria.

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Pantothenic acid has a wide range of health benefits
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Date: December 28, 2010 11:42 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Pantothenic acid has a wide range of health benefits

Pantothenic Acid Benefits

Pantothenic acid is otherwise known as Vitamin B5 and is a member of the B vitamin complex. Among its various health benefits are helping to alleviate such conditions as hair loss, asthma, allergies, respiratory problems, heart disorders, osteoarthritis, skin disorders and much more, so what is it about this substance that is possesses so many health benefits?

Pantothenic acid is an essential component in the synthesis of the ubiquitous Coenzyme A that is found in every cell in your body. Coenzyme A (CoA) is necessary for the formation of the acetyl-CoA that enables carbons atoms to be moved within cells. It is also an essential factor in the Kreb's or Citric Acid Cycle that generates ATP energy in every cell in your body.

pantothenic acid and krebs cycleMany other extremely important substances rely on Pantothenic acid and CoA, such as the biosynthesis of cholesterol (needed for sex hormone production), the neurotransmitter acetylcholine and fatty acids which are essential for a healthy heart, immune system and many other biological processes. Little wonder then that a pantothenic acid supplement offers so many benefits to your health.

Pantothenic Acid for Healthy Hair and Skin

Most young people value the look of their hair and skin, and pantothenic acid is largely responsible, along with several other essential vitamins, for their health. Otherwise referred to as Vitamin B5, pantothenic acid is contained as an ingredient in a wide range of shampoos. This was done as a reaction to the possibility of a deficiency in pantothenic acid leading to loss of hair color and skin irritation.

In fact this occurred only with mice, and its use in shampoos has never been proved, though all that may indicate is that there has never been enough testing carried out - which might well be the case. However, there is more evidence for its effect in maintaining a healthy skin, and tests have indicated that pantothenic acid, taken both orally and topically, can help to improve the appearance of the skin within between a week and four weeks of commencing the treatment.

There is more evidence available for this effect of pantothenic on skin health and in reducing the incidence and appearance of acne, largely because of the properties of Coenzyme A, a powerful antioxidant and anti-inflammatory that can destroy the free radicals that damage skin cells. It can also reduce skin inflammation, which will in turn reduce the inflammatory appearance of acne and other skin conditions.

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You can protect your liver and more with Milk thistle Extract
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Date: December 23, 2010 09:48 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: You can protect your liver and more with Milk thistle Extract

Milk Thistle Benefits

from plant to bottle, milk thistle worksMilk thistle has been used to treat liver problems for centuries. Its Latin name is Silybum marianum which explains the name of its main flavanoid complex, silymarin, which is obtained from the seeds. Milk thistle offers both a regenerative and a boosting effect to the liver, improving its effect on toxins while enabling it to recover from damage caused by cirrhosis, hepatitis and the effect of toxins and drugs.

Milk thistle also helps to reduce the cholesterol content of the blood and to improve the generation of glutathione, the body's master-antioxidant. Many studies have shown that milk thistle enables patients to survive longer after life-threatening liver conditions such as cirrhosis, and also protects it from the effects of sustained use of common drugs such as acetaminophen (Tylenol and Paracetamol) that progressively damages liver cells, and also of many antipsychotics and antibiotics that have a similar effect.

There are no doubts that taking milk thistle does your liver a great deal of good and leaves it in a much healthier state than it found it.

Milk Thistle and Painkillers

Over the counter painkillers such as Tylenol and paracetamol are based upon a chemical known as acetominophen. Milk thistle can be used to reverse the damage that acetaminophen can cause to your liver if you catch it early enough. Here is how this form of painkiller can cause damage to your liver.

Acetaminophen undergoes processes known as sulfation and glucuronidation prior to being excreted from the body. This process is not harmful to the liver, and is a normal biochemical means of removing excess acetominophen from your body after it has done its work. However, if you have taken excess acetaminophen (>4g/day or 8x 500mg tablets) there is too much for the above process to handle, and a secondary biochemical route (the cytochrome p-450 system) is taken that generates an intermediate product known as NAPQI.

Normally, this NAPQI is safely metabolized by the antioxidant glutathione but if there is insufficient glutathione in your system then the NAPQI will destroy cells in your liver. That can occur if too much acetaminophen has been taken for the glutathione to handle, if alcohol is also involved or if the diet of the patient is nutritionally deficient. If left untreated this condition can be resolved only by a liver transplant, without which it is usually fatal. Milk thistle can help to repair this damage and survival is more likely with patients who take milk thistle than those that do not.

milk thistle seeds for healthy liverSo if you take acetaminophen or drink alcohol on a regular basis, or you just want to protect your liver, what is stopping you from taking milk thistle?

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Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination
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Date: March 22, 2010 09:07 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Fight Inflammation With Inflama-Care - Anti-inflammatory herbal combination

turmeric root sample for articleTurmeric / Boswellia Complex

Our modern lives have untold benefits, as well as great challenges. Our dependence on man-made toxic chemicals, junk food, nutrient-imbalanced diets, and our stressful, sedentary lifestyles can alter our biochemical metabolism and affect our health. These unhealthy lifestyles and environmental changes have set our immune system on overdrive, a state call metabolic inflammation. Planetary Herbals Inflama-Care is a potent, herbal response to these modern challenges.

The Inflammation Cycle

As toxins and stress begin to alter our body chemistry and change the function of vital tissues, our body reacts with metabolic inflammation just as if it were being attacked. This reaction may result in a perpetual cycle of chemical imbalances and suboptimal health. Yet metabolic inflammation is often below the threshold of perception, not noticed or felt for years after its starts. It is only much later that the altered biochemistry and the system imbalances that it generates are noticed.

A Powerful Herbal Blend boswellia sample for article Inflama-Care helps support the body’s natural response to metabolic inflammation. The main component of the formula is the rhizome of the curcuma species, long used as a spice in India. Known worldwide as turmeric (Curcuma longa), it acts as an anti-inflammatory by inhibiting the activities of cytokines—inflammation messengers. This world-renowned spice is supported by boswellia, which inhibits proinflammatory enzymes, and ginger, an antioxidant that inhibits prostaglandin and leukotriene biosynthesis. Other herbs in the formula that inhibit inflammatory action include willow bark, Chinese skull cap, corydalis, holy basil, and hops.

The PhytoDynamic Difference

Planetary Herbals presents inflama-Care to help maintain the body’s biochemical balance and integrity. Inflama-care was formulated with a profound understanding of the ways in which plant compounds interact with human physiology. Planetary Herbals phytodynamic principles draw on herbal tradition, scientific research, and a level of clinical expertise unmatched in the natural products industry. Thie result: herbal products unsurpassed for quality and consumer satisfaction.
Inflama-Care 60 tabs from PLANETARY HERBALS

Amount %DV
Calories 5
Calcium (naturally occurring and dibasic calcium phosphate) 57 mg 6%
Sodium (naturally occurring) 5 mg <1%
Turmeric Rhizome Extract (95% curcumin) 900 mg
Boswellia serrata Gum Resin Extract (85% boswellic acid) 400 mg
Ginger Root Extract (5% gingerol) 250 mg
Willow Bark Extract (15% salicin) 100 mg
Chinese Skullcap Root Ext. (30% flavones) 100 mg
Bromelain 100 mg
Papain 100 mg
Hops Flower Extract (Perluxan™) yielding 30 mg Humulex™ alpha-acids 50 mg
Corydalis yanhusuo Tuber 50 mg
Holy Basil Leaf Extract (2% ursolic acid) 50 mg
Quercetin 50 mg
Rosemary Leaf Extract (20% diterpenes) 50 mg
trans-Resveratrols (from Polygonum cuspidatum root extract) 25 mg
Masson Pine Bark Ext. (95% procyanidolic value) 25 mg
Grape Seed Extract (95% procyanidins) 25 mg
EGCG (epigallocatechin gallate) (from decaffeinated green tea leaf extract) 25 mg
Lecithin 25 mg
Black Pepper Fruit Extract (Bioperine®) 5 mg

~video~

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L-Methionine
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Date: May 02, 2009 11:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: L-Methionine

Methionine is an essential amino acid, meaning that it is not synthesized by the body, and so has to be taken as part of your diet. It also contains sulfur, one of two sulfur-containing amino acids that can form proteins, the other being cysteine. It is a precursor for taurine, which is an aminosulphonic acid, and not strictly an amino acid, which together with cysteine supports the health of your cardiovascular system and helps to eliminate toxins from the body.

Maintenance of Cell Membranes

It is also an important intermediary in the maintenance of cell membranes. Phospholipids are fat-soluble components of the cell membrane, phosphatidylcholine being a very important example. Also known as lecithin, this substance is derived from choline, itself biosynthesized in a chemical pathway involving S-adenosylmethionine.

This substance is made in the body from ATP (adenosine triphosphate) and methionine with the help of the enzyme methionine adensosyltransferase. Known as SAM (or SAM-e), S-adenosylmethionine employs a number of metabolic pathways in its reaction, though generally aminopropylation, transmethylation and transsulfuration. These add aminopropyl, sulfo and methyl groups to a number of substances, the most common being the methylation of proteins, nucleic acids and lipids.

Phosphatidylcholine is produced by the enzyme-catalyzed sequential methylation of phosphatidylethanolamine, SAM donating the methyl groups. The maintenance of the integrity of the cellular membrane by phosphatidylcholine is critical to all of the basic processes in human biology, including communication between cells, flow of information and bioenergetics.

A by-product of this reaction is homocysteine, formed in the liver from the S-adenosylhomocysteine that SAM is changed to after donating methyl groups. Excess homocysteine in the blood can create the risk of myocardial infarction and cardiovascular disease. SAM is also of use in the treatment of depression and of arthritis.

Muscle Development

Creatine is a substance well known to athletes as being useful in provide short-term energy for high-intensity training. Although available in the diet, about 50% creatine used by the body is biosynthesized from methionine and two other amino acids, glycine and arginine. It allows a burst of energy lasting about 10 seconds, carried out without the use of glycogen reserves or fatty tissue.

Glycine and arginine combine to release ornithine as a by-product, and form guanidino acetate. SAM donates a methyl group to the latter to form creatine, about 95% of which is then stored in the skeletal muscle tissue. The stored creatine phosphate has the effect of allowing the muscle cells to hold more water, which also enables an enhanced level of protein synthesis, and hence an increase in muscle bulk, which also results from the increased blood flow resulting from the short-term high-intensity exercise that creatine allows.

Creatine can also increase the levels of MRF4 (myogenic transcription factor), resulting in an increasing in the myonuclei provided by satellite cells to damaged muscle tissue, that not only repair damaged muscle fibers, but also increase their ability to grow.

Detoxification of the Liver

Substances that help the liver to process fats, or lipids, are known as lipotropic, and the important lipotropics in human biochemistry are imositol, betaine, choline and methionine. They prevent fat from accumulating in the liver, and methionine is also useful in its effect of glutathione. This is a substance that helps the liver to neutralize toxins, such as excessive doses of acetaminophen, and its supplies are regulated by methionine.

Methionine and Autism

Research into autism is closely studying the Methionine/Glutathione Transsulfuration Pathway. This pathway is a very important biochemical means of detoxification, whereby toxins are methylated and then excreted. This pathway seems to be disrupted in autistic individuals.

Not only that, but disruption can lead to oxidative stress which results in many health problems. An example of this is the build-up of the oxidant homocysteine when there is insufficient Vitamin B6 to convert it into cysteine. This has been discussed previously, and is discussed again below.

Miscellaneous Benefits

Although research is in its infancy, it appears that AIDS sufferers also have decreased levels of methionine in their blood. It is believed that the process of AIDS could be linked to this, particularly the dementia that can occur as a result of the deterioration of the nervous system.

It is also hoped that it can help with some symptoms of Parkinson's disease, and pancreatitis. Initial research into this use of methionine has been very promising, as are studies into its use for urinary tract infections. It appears to operate like cranberry in this respect, preventing bacteria from attaching to the cell walls and multiplying in the urinary tract.

Methionine is believed to be essential for the formation of collagen, and for healthy pliable skin, hair, nails and other forms of connective tissue. For this reason it is often used as a supplement for the treatment of arthritis, although an excess should be avoided for reasons discussed above. S-Adenosylmethionine generates homocysteine during the biosynthesis of phosphatidylcholine, and this can cause cardiovascular problems.

So stick to the recommended doses when you use methionine as a supplement. Used properly, and according to instructions, it offers many health benefits, and can also be used to bulk up your muscle tissue and give increased energy when you need it most.

Dietary sources include fish, eggs, lentils, onions, garlic, meat, seeds, spinach and yoghurt. A good supplement would be from 800mg - 1000mg per day, and is best taken along with a B vitamin complex, or at least folic acid and vitamins B6 and B12, in order to prevent the increased generation of homocysteine.

Methionine also promotes the excretion of estrogen, so is a possible supplement for women on oral contraceptives that lower the production of this hormone. The elderly might also benefit from a supplement although, if taken for any specific condition, your health professional should be consulted first, as they should be for any supplement.

Nevertheless, methionine is a very useful supplement, and can be taken to prevent a large number of conditions. Research is continuing on its effect on AIDS patients, and Parkinson's, and it is hopeful that it will one day be recommended to help people suffering from these conditions.

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Vitamins Herbs And Antioxidants
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Date: October 17, 2008 09:48 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitamins Herbs And Antioxidants

Grilling meat over an open fire is something our ancestors have been doing for thousands of years. But people today who are indulging in chicken and cheeseburgers face a lot of concerns that our ancestors never even dreamed of. These include air pollutants and cancer-causing compounds. Research has proven that grilling meats creates two types of compounds that can lead to cancer. More so, both briquettes and lump charcoal spew hydrocarbons and soot particles as they burn, which encourage global warming contribute to many health problems. However, the majority of us cannot resist barbeque. So instead of dodging barbequed food, learn to grill without the guilt and fewer health risks.

Barbeque emissions are well below those from motor vehicles and the industry in rank, but its environmental effects are just as harmful given that burning charcoal contributes to smog and global warming. Lump charcoal is actually made from charred wood, which is a factor in deforestation. It can be compared to fuels that we use in furnaces and water heaters, such as oil, gas, and wood. Like these other fuels, charcoal produces soot when it is burned. These particles in soot are air pollutants and microscopic solids which are inhaled and deposited in the lungs. Particle pollution is associated with asthma, strokes, heart attacks, lung cancer, and reduced life expectancy. Once animal fat drips onto the flame of a charcoal or gas grill, carcinogenic compounds rise with the smoke and are deposited on the meat. Other harmful chemicals are then formed on the food as it continues to char. The more time the meat spends on the grill, the more harmful chemicals that are created. These compounds do not form on vegetables, as it is a reaction with animal-based foods that generates the harmful effects. However, any food that is over-charred contains other types of cancer-causing substances.

Grilling is a method of cooking that adds to the formation and deposit of cancer-causing substances on meat, as both substances deposited are undesirable and carcinogenic. The high heat of grill cooking produces more harmful chemicals than oven roasting or baking a lower temperature, but beef and chicken must both be cooked at temperatures high enough to destroy E. coli and other harmful bugs.

Because cancer risk is influenced much more by long-term patterns than occasional patterns, the goal is to have a diet that balances calories you take in with calories you put out, and to eat a diet containing many fruits and vegetables. Grilling less meat and more vegetables can reduce pollution on many levels. Also, vegetarian sources of protein, such as veggie burgers, contain few or no harmful chemicals when grilled. So for those summer days when a barbecue is irresistible, be sure to use natural charcoal, which is made from environmentally friendly wood sources and low-emission plant wastes.

Thankfully, all natural charcoals are chemical-free. In order to minimize cancerous compounds on the grill, cook at lower temperatures and flip meat every one to two minutes. Marinating meat or precooking it in a microwave for two minutes will also reduce hazardous compounds and carcinogenic compounds can be reduced by grilling lower-fat meats with fewer fat drippings.

By simply limiting the animal protein portion and making vegetables and grains a larger part of the meal, you can minimize the carcinogens and maximize your intake of cancer-protective vitamins and natural compounds. For most eliminating meat is undesirable, so supplementing with herbs and vitamins that help boost the immune system and act as antioxidants such as grape seed extract, vitamin c, and bioflavonoids can help the body fight off those nasty carcinogens produced from grilling.

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GrapeSeed Extract
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Date: October 15, 2008 09:46 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GrapeSeed Extract


It is possible to fight off aging with grape seed extract due largely to the antioxidant effect of the phytochemicals contained within the seed of the grape. The seed is rarely absorbed by your body because it is so difficult for your digestive juices to break down; significantly more difficult than the skin or the pulp. So what is specific about the seed that makes it so useful as a source of antioxidants? That shall be discuss shortly, but for now let's discuss the causes of aging, and how antioxidants can help to keep them at bay.

To fight off aging you have to understand what causes it, and the take steps to avoid these causes. It is fairly obvious that all causes of aging cannot be circumvented, but there are things that can be done to keep some of them at bay. Here, we are specifically concerned with the aging of your skin, which is the most visible form of aging. The first aspect of aging to understand is that there are two types: intrinsic and extrinsic.

Intrinsic Aging

Intrinsic aging is natural aging, and is largely genetic. Starting when you are fairly young, normally in the early to mid 20s, intrinsic aging is typified by wrinkling, hair loss or graying of the hair, hollowing of cheeks and other areas where the fat underneath the skin that normally contributes to your physical appearance is lost, and also bone loss that causes your skin to sag due a gradual loss of the structure that sculpts your physical appearance.

The age at which this occurs, and its speed is determined by your genes; although the process generally begins around the mid 20s, the speed with which it progresses is genetically controlled.

Extrinsic Aging

This is where grape seed extract can help. Extrinsic aging is not genetic, but environmental. Ten majority of this type of aging is due to exposure to the damaging UV light of the sun, which cause the typical 'leathery' look of the skin of people raised in areas such locations as the hotter parts of Australia and the USA, without the benefit of the native skin pigmentation that filters out these harmful ultra-violet rays.

Other factors that can cause the same degradation of your skin cells are smoking, the way you sleep and gravity. The sun generates free radicals (more on these later) that can destroy skin cells, cause freckles, leathery skin and a blotched complexion and also skin cancer. Smokers are more likely to develop leathery and wrinkled skin than non-smokers, and as the elasticity of your skin reduces, gravity cause jowls to develop and also a more pronounced lower lip.

Even your sleeping position can make you appear to age quicker, particularly using the same sleeping position on your pillow each night that cause what are known as sleep lines, that are really wrinkles that are difficult, if not impossible to remove. However, one of the most relevant factors is pollution, and the effects of car emissions, pesticides and other agricultural chemicals, paint fumes and 1001 other forms of chemical pollution that produce free radicals.

Where grape seed extract is involved in fighting off aging is in extrinsic aging is by destroying the free radicals. All substances, from the air to the oceans, are formed of atoms that contain electrons. Stable molecules contain an even number of electrons, or what are known as 'electron pairs'. When a molecule loses one electron it is known as a free radical, whose prime purpose in its very short life is to steal an electron from the nearest molecule. This 'short' lifetime can as long as a day or as short as thousandth of a second: it depends on is size and the degree of steric hindrance to the reaction with the spare electron.

Now that the reasons for aging and the nature of free radicals are better understood it is easier for you understand why grape seed extract can help to fight aging caused by the effects of free radicals on your skin.

Grape seed is a waste product of the wine industry. You cannot make wine from grape seeds, so they are removed from the final product by filtration or sedimentation. It contains a large number of phytonutrients, the most important being polyphenols in the form of flavanoids, lipids and carbohydrates. It also contains proteins that don't have much of an effect on aging. Flavonoids (also spelled flavanoids) are powerful antioxidants that destroy free radicals; they are twenty times as powerful as Vitamin E and over fifty times more powerful an antioxidant than Vitamin C.

Both of these vitamins are regarded as strong antioxidants in their own right, which is an indication of how good grape seed extract is at killing free radicals. It's like a combination of Harry Callahan, Paul Kersey, John McClane and the whole of the Magnificent Seven after the scavengers in your body cells. They succeed, and do it in spades!

Not only do the ingredients of grape seed extract kill off free radicals with the efficiency of a Delta Task Force, but are also anti-allergenic, anti-inflammatory, anti-cancer and anti just about anything else you can think of. However, let's have an even closer look and find out exactly what polyphenols are present in this so-called wonder juice.

Procyanadin was originally named Vitamin P in 1936 by its discoverer, Prof. Jacques Masquelier, and is believed to bond with collagen to protect you from premature aging by retaining and even improving the elasticity of your skin. An added benefit is that it also improves the elasticity of your blood vessels, and so helps to fight off the effects of high blood pressure and places less strain on your heart. The overall effect on your face is to practically give you a chemical face lift and also provide protection from the damaging effect of the UV component of sunlight through its lethal attitude towards the free radicals that UV radiation generates.

Another component of grape seed extract particularly that of muscadine grapes is resveratrol; a phytoalexin that has strong anti-inflammatory properties and can also fight off the effects of aging. Phytoalexins are antibiotics produced by plants that are under attack, and, in addition to helping you age slower, confers other benefits to your body including helping your brain to carry out its work more efficiently.

All in all, grape seed extract confers many benefits to your health and is also believed to possess powerful anti-cancer properties. However, it is for its ability to fight off aging that most people use it as a supplement, and in this respect it has been found to be extremely effective. Any antioxidant is of benefit to your body, but grape seed extract is of particular benefit due its high antioxidant potency.


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Colon Cleanse And Enema
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Date: September 08, 2008 09:49 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Colon Cleanse And Enema

While on a colon cleanse, it is extremely important to take a daily enema, a coffee or garlic enema is suggested, but inter-changing the two may be a good idea. When coffee enemas are taken, be sure to use 8 rounded tablespoons of regular grind coffee with 2 quarts of water. Be sure to boil thoroughly or perk first. A garlic enema can be made by emptying two capsules of garlic into two quarts of warm water and mixing well. The following steps should be followed when taking an enema. First, lie on your left side and let in ½ to 1 cup of enema water. Next, massage the lower left side of your abdomen, working especially hard on any lumps or ridged areas that you may feel, as these are deposits of fecal matter. After four to five minutes of massaging, let more water in. Then, continue to massage across the abdomen and down your right side, as this is where the greatest problems occur. Make sure to be especially thorough in massaging this area. Do not retain the liquid if you feel the need to eliminate. Instead, simply start over. Most people have expelled brown or grey mucous, black fleck-like matter, parasites, and other surprising matter.

Slantboard exercises are extremely important in helping all pocketed lazy bowels and are a great help for colon problems, prolapsus, and gas. It also regenerates the vital nerve center of the brain. Most people are able to use a slantboard. However, those with high blood pressure or any other problem that would contra-indicate a slantboard exercise should not use this method. The mini trampoline is probably one of the best devices ever invented, as it can increase circulation, empty the lymph glands, exercise the heart, and increase energy. It is recommended that one jump every day while they are on a seven day cleanse.

Most individuals should stay on a colon cleanse for at least a full seven days and repeat this program twice a year. This is especially true for those who are interested in the prevention and maintenance of good health. People with chronic health problems should repeat the cleanse four times a year and also follow a building program in the meantime. Nutritionists often suggest a year round use of the bentonite, but many believe that the bentonite cleanse should be alternated with a building program that is individually designed to meet each person’s specific needs. This program should include a variety of herb formulas that will help to rebuild the colon and supplements that are specific for individual problems.

It is suggested that people cut down on processed foods such as white sugar and flour where ever possible. Also, use foods that have the least amount of chemical additives like artificial food colors and preservatives. Whenever possible, eat mainly foods that spoil because of not having added preservatives, such as fresh fruits and vegetables. Also, use a wide variety of vegetables, raw or cooked in way that keeps in the most of the nutrition. When one does eat frozen foods, the fluid released in thawing often does have nutritional value. Make sure to avoid a steady intake of junk foods like candy and soda drinks.

Therefore, substitute natural sweets with fruit juices when you can do so. Also, exercise regularly and take into consideration your age and general health. While taking a colon cleanse, it is usually a good idea to consume only liquids for the first two – three days to help elimination. Consult your doctor if on medications so that a colon cleanse does not conflict with your medications.

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Gac Fruit Oil
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Date: August 25, 2008 07:04 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Gac Fruit Oil

Most people have never heard of gac fruit, yet it is very popular in South East Asia, particularly in China and Vietnam. The fruit is grown on vines that reach the size of a cantaloupe and from North East Australia across to China and Vietnam it is used as both a food and a medicine. It is only fairly recently that it has found use in the West as a health food

So what’s so special about this fruit, known also as baby jackfruit and sweet gourd? Its bright red color should provide a clue, since it is jam packed full of beta carotene, lycopene and other strong antioxidants that not only helps to support the immune system, but also helps to retard the effects of aging. It has been used in Vietnam in particular to overcome the effects of an endemic deficiency in vitamin A, and is rich in provitamin A carotenoids. It is also widely used in Chinese medicine to treat a variety of complaints.

Antioxidants and Free Radicals

Antioxidants can boost health in a number of ways, and it might help you understand better the benefits that gac fruit can provide to explain what antioxidants do and why they are such an essential part of our diets. Every millisecond of every day of our lives, our natural metabolism of the conversion of blood glucose to energy generates small oxygenated molecules known as free radicals.

Free radicals are molecules that possess an unpaired electron and are highly unstable. Electrons generally travel in pairs, and when one of that pair is lost through a chemical reaction, the other electron has only one purpose in its short life: to pair up with another electron and it will do whatever it has to in order to achieve that. It is called a free radical, and its life is short. Free radicals destroy body cells, and this can have a dramatic effect, both visually on your skin, and internally on your general health.

Apart from those generated by your body’s own biochmemistry, free radicals are present in car emissions and other pollutants such as pesticides, smog and fried and barbecued foods. They are also formed in your skin by excessive exposure to the UV component of the sun’s radiation. That is why the skin of those living in hot climates tends to age earlier.

Free radicals are what make you look older as you grow older: they destroy skin cells as they are formed, but that is one of the least of their effects. They can also oxidize low density lipids (LDL) that carry cholesterol around your body, causing it to deposit fatty plaques on the walls of your arteries, which is a serious cardiovascular condition known as atherosclerosis.

Antioxidants can donate an electron to free radicals without then becoming free radicals themselves, and so destroy them as they are formed. However, the antioxidant can then lose its reducing power. Free radicals do not roam the blood seeking victims as many imagine them to, but react almost instantly, as soon as they are formed. It is important, therefore, that antioxidants are present in or close to every cell of your body. To achieve this, they must be bound to a fatty molecule, and the problem with many phytonutrients is that they have no associated fats or oils to carry them into the fatty tissues of the body.

Nutritional Constituents of Gac Fruit

Not so with gac fruit, because in addition to the beta carotene and lycopene content, it is also rich in long-chain fatty acids, particularly linoleic and alpha linoleic acids. Not only that, but its beta carotene content is around ten times that of carrots, and it contains 70 times the lycopene of tomatoes! Vitamin C is another very powerful antioxidant, and gac contains 60 times the Vitamin C of oranges. It is also rich in other free radical busters, such as xeoxanthins and alpha-tocopherol, a form of vitamin E.

Altogether, gac fruit contains a free radical killing arsenal that should be enough to scare even the most courageous free radical back to where it came from. Other constituents of gac are numerous minerals, particularly zinc and iron.

That is why the sweet gourd is such a prized fruit, and why Southeast Asian women have skins that western women of the same age would die for! Antioxidants help to prevent the disruption and destruction of skin cells that are the major reason for aging looks, and why skin creams are packed with vitamins A and E, both strong antioxidants.

Health Benefits of Gac

Most of the health benefits of gac are provided by its antioxidant properties. Thus, if you have a high cholesterol level, gac can help you to avoid atherosclerosis by preventing the oxidation of the LDL cholesterol, which is the precursor to it depositing on your artery walls. The body needs cholesterol, but levels should be kept to within certain limits or the resultant atherosclerosis can narrow your arteries leading to cardiac problems and strokes, particularly in the very narrow arteries of the brain.

Gac also supports the immune system and helps to maintain prostate health, largely through its alpha tocopherol, or vitamin E content. Vitamin E is easily destroyed by free radicals, which is where the beta carotene is of benefit. This is the body’s first line of defense against free radicals, and each molecule can neutralize up to 20 free radical molecules before it is destroyed. This helps to save other antioxidants such as vitamin E.

Lycopene is particularly beneficial to the prostate and current research indicates that it can help to prevent prostate cancer and cardiovascular disease, plus some other diseases such as macular degeneration that affects your sight. Perhaps this is one reason why the gac fruit membranes are used in Vietnam to promote healthy vision, and they also help to cure dry eyes. Lycopene remains in your body fat longer than normal beta carotene, and recent studies have found that men with high amounts of lycopene in their body fat are up to 50% less likely to suffer heart attacks as those with low amounts.

Gac fruit is jam-packed full of nutrients and antioxidants, and has no known side effects. It is used in Asia for weddings and other special occasions, and is grown on lattices in many gardens, although it has a short season. However, gac fruit is not known as the “Fruit from Heaven” for no reason, and if you were allowed the choice of only one fruit in your life, then this would be the one.

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B Vitamin Complex
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Date: June 23, 2008 03:19 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: B Vitamin Complex

The vitamin B supplement you take is a mixture of nutrients that, although they share the same vitamin letter, are in fact distinctly different chemical entities. The reason that they share the same reference letter of the alphabet is that they are all essential water soluble vitamins (Vitamin C being the only other), they frequently work in synergy with each other and they often come from common sources and have similar properties in the body. They were therefore at one time believed to be just the one chemical entity.

They are essential in that they must form part of our diet because our bodies cannot manufacture these substances from others, and although most share common biochemical and health functions, there is no health function that requires all of them, and none of them can be totally replaced by another.

The B-Vitamin complex that you take can consist of as many as eight different B vitamins, each of which is essential for a healthy body and at one time it was believed that this mixture was only one single vitamin. That is why they are collectively known as vitamin B and were subsequently allocated numbers: it was only later that the individual components were discovered.

These eight are vitamin B-1 (thiamine), vitamin B-2 (riboflavin), vitamin B-3 (niacin), vitamin B-5 (pantothenic acid), vitamin B-6 (pyridoxine), vitamin B-12 (cobalamins), biotin and folic acid (folate). They are found in yeast, liver, tuna, bananas and rice among other sources, and, as with all vitamins, without them life would not be possible. Not all vitamins are found in each of these food sources, and vitamin B-12, for example, is available in nutritional quantities only from animal sources.

Knowing what they are is all very well, but what does your body do with the B vitamin supplement that you take? Before considering that, the reason that a regular supply is important is because of their water solubility. This is a useful property for a vitamin to possess, because it means that they can easily be transported by the body fluids to the tissues where they are needed. The downside, however, is that they are consequently also easily flushed from the body, and your body cannot store any of the B vitamins.

You therefore must have a regular dietary source that can be augmented through supplementation. This is particularly desirable in alcoholics, those on diets to lose weight and vegans who are advised to take a regular vitamin B-12 supplement.

A lack of vitamin B will make you feel tired and lack energy because they play a big part in your body’s metabolism of blood glucose into energy. They also help to maintain a healthy immune system, keep your nervous system in tip-top condition and maintain good healthy skin, hair and muscles. The B complex is also very important in maintaining healthy blood and liver, and each and every component of the mixture has a specific part to play, both on individually and by interaction with others in the B complex.

Rather than examining what your body does with the supplement as a whole, let’s have a look at each component, and what your body does with that. Taking them one at a time, thiamine (B1) helps you to burn carbohydrates to generate energy. It is highly water soluble and must be taken daily. In the form of thiamine pyrophosphate it plays a key part in the metabolism of carbohydrates to energy, and also in the metabolism of certain amino acids. If you rely heavily on a high carbohydrate diet, you will need a good regular supplement of thiamine to be able to convert them to energy.

Vitamin B2 (riboflavin) also plays a part in fat and carbohydrate metabolism and the formation of adenosine triphosphate (ATP), the molecule of energy. It plays a significant part in the health of your skin and a deficiency is associated with mouth ulcers, cracked lips, flaky skin and bloodshot watery eyes. It also activates vitamin B6 and folic acid, one of the cases where the B vitamins work together synergistically.

Vitamin B3, or niacin, is well known to women as a component of some shampoos, and helps to promote health hair. However, this vitamin also takes part in the process of energy creation within your body, and helps to maintain a good muscle tone within the digestive tract. It is also used as a supplement for the treatment of diseases related to high levels of LDL cholesterol and is useful for the treatment of atherosclerosis.

Pantothenic acid is also found as a component of shampoos, so no prizes for guessing one of its functions. Vitamin B-5 plays a significant part in the energy-producing Krebs Cycle, or Citric Acid Cycle, that is used by every cell in your body to generate energy just where it is needed. It is also needed to synthesize acetylcholine, a neurotransmitter needed for good brain function and it helps to reduce stress. Pantothenic acid is also closely involved in the production of cholesterol in your liver: cholesterol is not all bad, and is needed by your body to produce some of the steroid hormones and also vitamin D.

Amino acids are the small units that are used to biosynthesize proteins and ultimately the genes and DNA that determine who you are. The major factor involved in processing these amino acids is Vitamin B6 (pyridoxine), one of the lesser known of the vitamin B complex. It synthesizes and breaks up different amino acids to produce a variety of other compounds, such as the hormones serotonin, melatonin and dopamine.

Deficiencies in these hormones can be very serious, Parkinson’s disease believed to be connected with a dopamine deficiency for example, and other disorders include kidney stones, anemia and many skin complaints. Although deficiency of vitamin B6 is rare, it can occur in alcoholics and those with chronic kidney problems. It is believed that many diets are deficient, however, and a good vitamin B supplement would ensure that this did not occur.

Vitamin B-12 is one where deficiency can occur, particularly in alcoholics and vegans. It is available in sufficient quantities only from meat sources, and a supplement is indicated in anyone with a low meat intake in their diet. It is used by your body for the replication of DNA and to allow the normal activity of your body cells. It also helps to control homocysteine levels in conjunction with vitamin B6 and folic acid: homocysteine is a high-risk amino acid associated with atherosclerosis and cardiovascular disease that can lead to Alzheimer’s disease, heart attacks and strokes.

The seventh, biotin (sometimes referred to as vitamin B7) also takes part in the metabolism of energy, but deficiencies have not been known, and the final known member of the B vitamin complex is folic acid. This is essential for cell growth and the synthesis of RNA and DNA in the body. RNA (Ribonucleic acid) is responsible for the synthesis of proteins in your body, and the well known Deoxy-ribonucleic acid (DNA) holds the genetic information of your body. Folic acid is therefore essential in the growing fetus, and any other cellular system that rapidly regenerates such as blood cells and the various cells of the immune system.

Without folic acid your body would be more susceptible to bacterial and viral attack, and less able to protect you from foreign invaders into your body tissues. Although deficiency is not common, folic acid is present in fresh food only and degrades when stored at room temperature and when cooked. A supplement is therefore advisable during pregnancy to help to prevent neural tube defects.

It is evident that the Vitamin B complex plays many parts in the chemistry of your body, and that a supplement can be of benefit in assuring that there are no deficiencies. A good B complex can be found at your local or internet health food store.



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Increase Absorption Of Your Discount Vitamins With Bioperine
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Date: November 02, 2007 04:54 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Increase Absorption Of Your Discount Vitamins With Bioperine

In order to understand how you increase absorption of your discount vitamins with Bioperine, it is necessary to understand the metabolic process of thermogenesis. First, however, let’s have a look at what Bioperine is and where it comes from.

Bioperine is obtained from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) of which it is a patented standardized extract. These peppers contain the alkaloid piperine, and the extract contains 95% piperine. The plants are grown in the ideal damp soil in regions of Southern India where the earth is rich in nutrients. The barriers are harvested just before ripening, and then dried in the hot sun before the extraction process is started. Piperine has many uses from flavoring to fly killer, but people have been using it for centuries to heal wounds though this is apparently unconnected with the use to which the extract is put.

It has recently been found to help increase the absorption of a number of discount vitamins and minerals, including Vitamin B, beta-carotene, and selenium, by increasing the thermogenic activity of the body. Thermogenesis is one of the metabolic processes of the body that takes place within our cells whereby glucose is converted to energy, but at an accelerated metabolic rate. It is the rise in the metabolic rate that is referred to as thermogenesis.

When you eat food, or take supplements, the metabolism increases above the normal rate, the amount of increase depending upon the type on nutrient taken. Fats will increase your metabolism at a lower rate than proteins will, for example, since more energy is needed to break down proteins than for fats. Another substance that stimulates thermogenesis is piperine. It does so by utilizing the biochemistry of the body so that the chemicals needed for thermogenesis are made available.

Piperine triggers the release of compounds known as catecholamines, hormones that in turn stimulate the thermogenetic process. However, this occurs over a short period of time, so the nutrients that are needed should be present in the gut as well since the window of absorption is very narrow. The substance also modifies the epithelial cell wall of the intestine to make it easier for the nutrients to be absorbed into the bloodstream, and it also gives amino acids a kick to get moving to the cells in which they are required.

Bioperine, then, not only sets off the metabolic changes that demand vitamins and other nutrients and enzymes, but also improves the conditions in your intestines so that these nutrients can more easily get to where they are needed. Basically, what Bioperine does is to cause the intestinal wall to become more permeable to nutrients, so that vitamins and drugs are not degraded when passing through the intestinal wall to the bloodstream. This improves digestion and absorption of minerals and vitamins, in addition to protein supplements frequently used in weight loss diets.

Bioperine starts by generating a need for nutrition and then increase the bioavailability of the nutrients provided to meet that need. However, due to the short window of absorption that piperine generates, the vitamins and minerals you want absorbed should be co-administered with the Bioperine so that they are in place ready to be absorbed at exactly the right time.

There have been several studies carried on the efficiency with which piperine achieves this. The absorption of three different types of nutrients has been measured with and without Bioperine. These were beta-carotene, a fat soluble vitamin, vitamin B-6, a water soluble vitamin, and also a mineral, selenium which was provided as selenomethionine. The absorption of these by the digestive system was measured by detecting them before and after in the blood, and were found to increase considerably when taken along with Bioperine, but not so with the control group without it.

Measured increases were a 60% increase in beta-carotene, similar to that of vitamin B-6, and was 30% in selenium. The tests used a 5 mg dose of the Bioperine. Other studies have indicated an increase in the absorption of Coenzyme Q-10 of between 30% - 200%. This is the only piperine based product that has been patented for its effect in increasing the absorption of nutrients into the body, and also the only piperine based product to undergo such tests in the U.S. to substantiate its claims and prove its safety for use.

The black pepper itself is a common household spice, and has been used in India for its medicinal properties for centuries. It is mentioned in the practice of Ayurveda and its concentration on the function of the digestive tract in human health. Many of its formulas contain black pepper amongst their ingredients. The bioavailability of nutrients is a significant factor in the health of any specific population, and the exponents of Ayurveda overcame this problem, by chance or design, six millennia ago. It has been demonstrated time and time again that diet is not the factor of importance in nutrition, but how much of that diet is absorbed through the intestines.

This is yet another example of the medicines of our ancestors being shown to have a solid scientific basis, and perhaps we should pay more attention to those others that are disregarded by modern science. It could be that we have only scratched the surface of understanding human metabolism and biochemistry, and that there is much left to learn. Ancient wisdom should never be disregarded.

Bioperine is also available in many supplement mixtures so that it is taken at the same time as the relevant vitamins and minerals. The recommended dosage is from 1 mg – 5 mg from 2 – 3 times daily. It takes around 2 – 5 mg of Bioperine to provide sufficient enhancement of absorption of the nutrients that are taken with it. Keep in mind that the nutrients are best taken at the same time, and that taking the extract itself will simple increase the absorption of any nutrients that are in the intestine at that time. Bioperine can be purchased at your local or internet vitamin store.



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Build Healthier Skin With Antioxidant Rich Skin Moisturizing Lotions
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Date: November 02, 2007 04:32 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Build Healthier Skin With Antioxidant Rich Skin Moisturizing Lotions

Antioxidant rich skin moisturizing lotions can help you to build healthier skin, since they can help to allow the appearance of the fine lines that eventually develop into the wrinkles that you dread.

Most people think about caring for their skin more in the summer when the sun is hot than in the colder winter months, but cold can also dry out your skin since you tend to sweat less. However, the summer brings with it the harmful ultraviolet rays of the sun to a greater or lesser degree depending on your climate. Tough leathery skin is generally associated with skin neglect by white skinned people in the hotter areas of the world such as Australia and the southern parts of Florida and California.

You should look after your skin since it is important to you. It not only keeps everything inside that should be kept inside, but also generates vitamin D and contains the temperature control system that your body relies upon. Elephants flap their ears, dogs pant and humans sweat! Without your skin you would be in a bad way, so you should look after it. If you don’t keep it supple it gets dry and hard, wrinkled, itchy and can crack, into which the bugs and viruses needed to make you ill can enter.

All of this occurs when your skin loses its moisture. In order to keep it in tip top condition, and keep yourself looking young and attractive, you should keep it moist through the use of artificial moisturizers if necessary. So why does your skin dry out and how do moisturizers work to help overcome the effects of drying?

In fact the major problems that occur with your skin due to exposure to sun in the summer have nothing to do with drying out. Your skin actually does, as suggested above, become more affected by dryness in the winter when the relative humidity is low. It is in winter that you have to use lip moisturizer because of dry and cracked lips, not summer. However, summer has its dangers, even more than winter.

It is the UV radiation from the sun that damages your skin and can ultimately lead to skin cancer. The UVA and UVB radiation are at different wavelengths and have different effects. The combination, however, causes wrinkles, skin disorders when aging, premature aging, and dry leathery skin. Part of this is believed to be due to the breakdown of the collagen in the skin that maintains its elasticity, free radical damage and inhibition of the immune system.

When UV radiation breaks down collagen it causes the accumulation of abnormal tissue. When this builds up, enzymes are produced that are intended to repair the collagen, but sometimes it does not work properly and produces a disorganized and random accumulation of collagen fibers that eventually result in wrinkles.

Free radicals are chemicals that have a free electron available, rather than having all electrons in pairs as in stable compounds. It is therefore unstable and will steal an electron from healthy tissue and so damage the cell that it takes it from. Eventually, the cells die and genetic material within the cells can be altered. This can cause wrinkling of the skin and underlying tissues or even cancer by changing the DNA and RNA contained within the cell.

The final defense of the body against cell damage is paradoxically apoptosis, which is suicide by the damaged cells to prevent them becoming cancerous. This is what you see when your skin peels after sunburn – it is deliberate action on behalf of the cells of your skin sacrificing themselves to save the body as a whole. UV exposure can prevent this from occurring which is why it can lead to some forms of skin cancer.

However, it is the action of oxidants on the skin that cause most damage. The so-called drying out of skin is largely due to oxidant damage more so than to loss of moisture. The sweat glands in your skin can produce lots of moisture, but nothing can be done about free radicals other than provide the help of antioxidants to kill them off. Antioxidants destroy free radicals with glee, and hunt them down wherever they are. The common antioxidants in your body are vitamins A, C and especially the powerful vitamin E. That is why so many skin creams contain vitamin E, and sometimes also vitamin A.

However, there are many more antioxidants than these. Astaxanthin is one. ‘Asta what?’ I can hear you say, and I am not surprised. It is not very common in health stores, but has been approved by the FDA and in Europe as a food colorant. It is a terpene carotenoid, though does not break down to vitamin A in the human metabolism as other carotenes do. It is claimed to be fifty times more powerful as an antioxidant than vitamin E and acts as an internal sunscreen in the skin by blocking the harmful effects of UV radiation at cellular level.

It is available naturally in krill, salmon, trout, crustaceans and some bird feathers, and is extracted from microalgae. Not all sources are palatable and it is best taken as a supplement, or to protect the skin, in a cream. Another super-antioxidant is pycnogenol. However, be aware of purchasing it under this trade name in the USA, since the term has been hijacked by others who are selling a different product under that name. The true chemical pycnogenol as named by Frenchman Dr. Masquelier is a very strong antioxidant: any others are mere imitations that are not the same product.

Chemically, pycnogenol is a proanthocyanidin, a flavanol extractable from grape seed or pine bark. Any product that comes from a different source cannot be pycnogenol. That said, the product is able to strengthen the skin and prevent wrinkles through its effect in scavenging free radicals. It stops the free radicals from destroying the cells of the skin and causing premature aging. Whether the chemical is extracted from pine bark or grape seed appears to make no difference. The chemicals are virtually identical, or should be if they are from the right form of pine bark.

The polyphenols in green tea also eradicate free radicals. They too are very strong antioxidants, just one of the remarkable properties of this plant. However, none of these will be of much help unless specifically applied to the skin. If taken internally, they will do a great job of mopping up free radicals in the blood, but very little will actually reach the skin.

In order to build healthier skin, you will have to use antioxidant rich skin moisturizing lotions that apply moisture to your skin, but more importantly also apply these powerful antioxidants. If you really want to maintain good looking wrinkle-free supple skin in sunny climates, then look for one or more of the above substances as an ingredient in your moisturizing lotion.



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Do you experience muscle pain and inflammation?
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Date: April 25, 2007 03:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Do you experience muscle pain and inflammation?

FlexAgility MAX

 

Everyone experiences muscle pain and inflammation due to overuse and exertion. We’ve all had those softball games, weekend camping trips or chore-intensive days when our body lets us know we’ve overdone it.

So, what can you do about it? Well, fortunately, there is a proprietary formula with clinically studied ingredients that provides a natural solution: FlexAgility MAX.

FlexAgility MAX is designed to reduce pain and inflammation due to overuse. Its clinically studied ingredients have been shown to help balance the body’s own inflammatory response. Let’s take a look at FlexAgility MAX and answer a few questions you may have about it.

 

Q. What is inflammation? Why does it happen?

A. Inflammation is actually an essential part of your body’s natural healing process. When some form of physical stress affects the body, the immune system responds by supplying defensive compounds to the stressed site. This is what causes the fluid build-up, pain and redness we typically associate with inflammation. And until the situation is resolved those symptoms will stick around. So, why is that good? Because without these signals – pain and inflammation – we’d probably do even more damage. In a sense, pain and inflammation are very effective stop signs.

The problem is, if our bodies are continuously bombarded by factors that trigger inflammation, these defenders (and their symptoms) are always around. This can mean unnecessary pain and inflammation following overuse and exertion.

 

Q. What does FlexAgility MAX have to do with inflammation?

A. FlexAgility MAX provides triple-action activity against occasional pain and inflammation, with powerful antioxidant free-radical scavengers, the enzyme bromelain, and a natural COX-2 inhibitor.

 

Q. So what is COX-2 and why should I inhibit it?

A. We’ve all been hearing a lot in the news about COX-2 inhibition and may have wondered about its connection to pain and inflammation. Let’s take a look:

Cyclooxygenase is an enzyme that comes in two main types, abbreviated for convenience: COX-1 and COX-2. The COX enzymes regulate compounds involved with inflammation, including prostaglandins. COX-1 is found throughout the body, and maintains the integrity of the stomach lining, circulation and kidneys.

COX-2 on the other hand, cruises along the central nervous system – it’s much more attuned to our brain’s sense of “what hurts.” Primarily activated by inflammatory stress, COX-2 generates prostaglandins – the hormone-like defensive compounds that cause the responses we associate with pain and inflammation due to overuse.

You can understand why so much research has focused on COX-2 inhibition. Decreasing its activity means short-circuiting the “inflammation cascade” that follows occasional overuse.

Because COX-1 is associated with a healthy stomach lining, it is not an enzyme you want to inhibit. Unfortunately, many products don’t know the difference between COX-1 and COX-2 – filing both with one blast.

Fortunately, there are ingredients in FlexAgility MAX that can tell them apart. One of them is IsoOxygene.

IsoOxygene is a patented hops extract shown in scientific studies to significantly inhibit COX-2, while leaving COX-1 alone. And, it is a 20 times more potent COX-2 inhibitor than other tested popular botanic products, including curcumin and grape seed.

 

Q. How do antioxidants support the body during times of inflammation due to overuse?

A. Overall, the body ahs a pretty darn good repair system. However, oxidative stress due to free radical damage can take its toll, especially during times of occasional physical stress. Free radicals and reactive oxygen species can damage cells, because they are hungry, unstable molecules in search of electrons. To find them, they attack other cells. These pillaged cells then become free radicals themselves, setting off a chain reaction of oxidative stress.

Free radicals are formed during the body’s normal functions, and can have benefits, such as neutralizing viruses and bacteria. However, in doing do, they erode the body’s own antioxidant defenses, too. And, free radicals typically become very active during times of inflammation due to overuse or other stressors.

The good news is that the herbal and antioxidant elements in FlexAgility MAX help support the body’s own natural anti-inflammatory defenses.

Take vitamin C, for instance. This extremely well-known antioxidant has been scientifically studied for its beneficial effects on muscle, collagen and connective tissue health. Collagen and connective tissue is what helps hold us together – literally.

And famous antioxidant, green tea, has been well-studied for the benefits of a polyphenol called epigallocatechin-3-gallate, or simply EGCG. In scientific and clinical studies, EGCG from green tea works as an overall antioxidant, scavenging free radicals, and supporting healthy collagen. In fact, one study showed that green tea polyphenols supported collagen health by 50% versus only 16% in controls.

The green tea extract in FlexAgility MAX is especially focused on these beneficial polyphenols. It’s standardized to contain 70% polyphenols – half from EGCG. The green tea acts in concert with elderberry and ginger in the formula to help prevent oxidative stress to the body due to occasional overuse.

Anthocyanins are natural antioxidants found in berries and vegetables. Black elderberry extract, one of the herbal ingredients in FlexAgility MAX, was shown in scientific studies to be more bioavailable – that is, more readily used by the body – than the natural bioflavonoids of other plants. Again, antioxidants help keep the body in optimum health- especially during times of physical stress.

 

Ginger, used for centuries in Ayurvedic medicine, provides strong, natural antioxidant activity. In fact, a recent scientific study found more than 50 separate antioxidants in ginger root.

Of course, there are many components of plants that show strong antioxidant properties. A scientific study comparing flavonoid antioxidant activity and inflammation have shown that rutin was the most effective in reducing the inflammation cascade.

 

Boswellia serrata is a tree found growing in the dry, hilly regions of India. Extracts of boswellia have been used in Ayurvedic practice for centuries. Boswellia also has antioxidant properties that help reduce free radical damage.

Another antioxidant ingredient in FlexAgility MAX, N-acetylcysteine (NAC), even helps the body produce more of its own antioxidants, cysteine and glutathione. In a double-blind, placebo-controlled clinical study, N-acetylcysteine inhibited occasional pain and inflammation due to overuse and attenuated fatigue by 26% compared to controls!

N-acetylcysteine has also been shown in scientific tests to act as an antioxidant, supporting healthy collagen and synovial fluid.

The last ingredient, bromelain, provides the enzymatic pathway used by FlexAgility MAX. Bromelain is a proteolytic enzyme derived from pineapple. Clinical and scientific studies showed benefits from bromelain in reducing pain and inflammation from occasional overuse.

So, there you have it- the triple action of FlexAgility MAX: COX-2 inhibition (and COX-1 sparing), antioxidant benefits, and enzyme support.

 

Q. Is there another product you’d recommend that I use with FlexAgility MAX?

A. One other product I recommend without hesitation is GS-500, a glucosamine sulfate supplement that has been shown to help build and support cartilage. The body’s connective tissue and cartilage include a natural compound called glucosamine. Supplemental glucosamine sulfate is up to 98% absorbable, so more glucosamine reaches the target structures. It has been clinically studied on its effect in building cartilage.

 

 

About Enzymatic Therapy:

 

Like Chris, Enzymatic Therapy is a trailblazer. Since our founding in 1981, we’ve been leading the industry with innovative natural products. After all, in 1993, Enzymatic Therapy introduced glucosamine sulfate, shown to help build and support cartilage, to the United States. Our product, GS-500, is up to 98% absorbable, so more glucosamine reaches the target structures.

In the intervening years, Enzymatic Therapy has been at the frontline of innovation and invention. Many revolutionary precuts, including Saventaro, Cell Forte, Heartburn Free, Petadolex Patented Brain Support, Whole Body Cleanse, Earth’s Promise, Hot Plants for Him and Hot Plants for Her have been introduced by Enzymatic Therapy.

One of the newest products, (and the reason you’re reading this) is FlexAgility MAX. FlexAgility MAX works with the body’s own natural anti-inflammatory pathways to relieve pain and reduce inflammation due to occasional overuse. Our proprietary FlexBend of ingredients, combined with antioxidants and the proteolytic enzyme, bromelain, is unique among natural products.



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Taming the Tingle – ALA helps fight nerve damage caused by diabetes…and more.
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Date: November 09, 2006 01:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Taming the Tingle – ALA helps fight nerve damage caused by diabetes…and more.

For some people the constant tingling in their feet is the worst part. Others feel like their feet are being stabbed or burned, or that their extremities are simply lifeless. All these folks suffer from peripheral neuropathy, nerve damage that afflicts nearly 30% of people with diabetes aged 40 and older. And if the discomforting sensations are not enough, neuropathy can lead to falls, wounds that won’t heal, even amputation.

Untold numbers of individuals have been helped by alpha lipoic acid (ALA), a supplement that European practitioners have used as a standard neuropathy treatment for 30 years. ALA (also known as thioctic acid) assists in the chemical reaction that generates energy within cells. It serves as a universal antioxidant—a substance that can fight tissue-damaging free radicals in both the fatty watery parts of a cell-and helps the body create additional free radical fighters, such as glutathione. ALA can even help regenerate several other antioxidants, including coenzyme Q10 (CoQ10) and vitamins C and E.

Defying diabetes

People with diabetes need antioxidant protection as much as anyone. Fortunately for them, though, ALA fights this insidious disorder in many other ways.

Diabetes occurs when the body can no longer effectively use glucose (blood sugar), its main energy sources; ALA helps shepherd glucose out of the blood and into cells. It also interferes with glycosylation, a process in which glucose sticks to proteins such as the low-density lipoprotein (LDL) that carries cholesterol through the bloodstream. That’s important because this “sticky” LDL can adhere to arterial walls, creating a major risk factor for heart disease. ALA combined with exercise appears to make insulin, the hormone that controls glucose usage, more effective. What’s more, early research indicates that ALA can deflect another cardio hazard by interfering with the ability of salt to push blood pressure upward (molecular and Cellular Biology 12/03).

ALA Annotations – what is it? Alpha Lipoic acid, a substance the body creates naturally.

What it Does: ALA, a powerful antioxidant in its own right, plays a vital role in the creation and renewal of other antioxidants. It is used to treat peripheral neuropathy; nerve damage caused by diabetes, and is also under investigation for possible therapeutic effects in other disorders, including multiple sclerosis and age-related cognitive decline.

Diabetes doesn’t just attack the nerves and the heart—its effects are felt throughout the body. That’s why scientists are examining whether ALA can tackle other diabetic complications: in lab studies it has forestalled diabetes-related kidney and eye damage. (Check blood-sugar levels regularly when using ALA, especially if you’re taking other glucose regulators.)

Protecting Nerves

While diabetes is one of the most common causes of nervous system damage, it isn’t the only one. In test tube studies ALA has promoted chemical reactions that encourage neurons (nerve cells) to survive and grow; as a result some scientists believe this natural antioxidant may eventually play a role in treating degenerative nerve disorders. Such research is in its beginning stages, but the results are still intriguing. For example, in mice ALA has slowed progression of a disorder that mimics multiple sclerosis in human beings (Journal of Neuroimmunology 3/04) and improved age-related memory loss when used with N-acetyl-cysteine (NAC), another antioxidant supplement (Journal of Neurochemistry 3/03). A number of other conditions that become more common with age may also benefit from ALA, including arthritis and thinning skin.

If you suffer from both diabetes and the nerve damage it causes, ask your practitioner about ALA. It just may help your feet and the rest of you feel happy. –Lisa James



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Benefits of Best Alpha Lipoic 35!
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Date: February 12, 2006 03:11 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Best Alpha Lipoic 35!

Benefits

Supports the Body’s Defense Against Free Radicals*

Recycles Antioxidant Nutrients such as Vitamin C and Vitamin E*
Helps Maintain a Healthy Blood Sugar Level when used as part of the diet*

Alpha-lipoic Acid––the "Ideal Antioxidant"
The antioxidant potential of a substance is based on a number of criteria, including:
1) Ability to quench specific free-radicals.
2) Ability to bind or "chelate" metal ions that can generate free radicals.
3) Supports function of other antioxidants.
4) Absorption/bioavailability.
5) Concentration in tissues, cells and extra cellular fluids.
6) Ability to function as an antioxidant in fatty and watery environments.


The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes.

As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3
1) ALA is easily absorbed when consumed orally.
2) ALA is readily converted to DHLA in various tissues.
3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.
4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.
5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.
6) DHLA recycles other important antioxidants.


DHLA-regenerates vitamin C, vitamin E and glutathione

Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.

DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7

Alpha-lipoic Acid and Blood Sugar

Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10



Safety

Suggested Adult Use: One to six capsules daily with food.

Alpha-lipoic acid is considered safe, and no adverse effects have been seen with long-term supplementation.1

Scientific References
1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50.
2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63.
3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31.
4. Serbinova, E. Maitra, I., Packer, L. The synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21.
5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561.
6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637.
7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87.
8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4.
9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14.
10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804.


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Benefits of Acetyl-L-Carnitine
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Date: February 12, 2006 01:55 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Acetyl-L-Carnitine

Benefits

Supports cognitive function*

ALC has been studied for its effect on cognitive performance and emotional health in the elderly. In a single-blind, placebo-controlled trial, 481 elderly subjects exhibiting mild memory impairment improved their scores on a memory test after taking 1500 mg of ALC a day for 90 days.2 Hospitalized elderly people taking ALC have shown improvements in mental outlook.3 While ALC is not a treatment or cure for Alzheimer's disease, double-blind studies suggest it may help slow the rate at which early-stage Alzheimer's patients deteriorate.4 In particular, ALC seems to benefit short-term memory in these patients.5

Supports biosynthesis of acetylcholine, a key neurotransmitter for brain and nerve function* Brain function requires coordinated communication between brain cells. Brain and nerve cells ("neurons") communicate across tiny cell-to-cell gaps called "synapses." The passage of an electrical impulse from one neuron to the next requires a "neurotransmitter." When an electrical signal arrives at the synaptic junction, the neuron releases a neurotransmitter into the synapse. The neuron on the other side of the synapse contains receptors for the neurotransmitter; these receptors bind the neurotransmitter, triggering a series of chemical events that sends a new electrical signal down the membrane of the receiving neuron. Neurotransmitters work together like an orchestra to transmit information throughout the brain and nervous system. Acetylcholine is the most abundant neurotransmitter in the body, regulating activities of vital organs, blood vessels and communication between nerves and muscles. In the brain, acetylcholine helps facilitate memory and learning as well as influence emotions. ALC is structurally similar to acetylcholine, and brain neurons stimulated by acetylcholine are receptive to stimulation by ALC.6 It has been shown experimentally that ALC supplies acetyl groups for the biosynthesis of acetylcholine.7 ALC's hypothesized cholinomimetic (acts like acetylcholine) activity has led researchers to investigate its effects on mental function and emotional health.8

Helps supply the brain with energy by improving energetics in the mitochondrion*

The acetyl groups donated by ALC can be used to synthesize acetyl-CoA, the key substrate for energy metabolism in the mitochondrion. 9 Acetyl-CoA enters the Krebs cycle, the mitochondrial mechanism that generates cellular energy in the form of ATP. ALC easily crosses the blood-brain barrier, allowing it to play various roles in maintaining brain neuron (nerve cell) function. When given by oral administration, the concentration of ALC is increased in the blood and cerebrospinal fluid.10

Stabilizes intracellular membranes*

ALC was found to improve membrane phospholipid metabolism in early-stage Alzheimer's patients.11 Phospholipids are structural components of brain cell membranes that regulate neuron function. ALC donates acetyl groups that can be used to modify the functional activity of proteins in neuronal membranes.12 ALC thus plays a role in maintaining membrane function. ALC also increases membrane stability and structural integrity.13

Increases nerve growth factor production*

The body produces various specialized proteins called "growth factors" which are essential to growth and repair of tissue. Nerve Growth Factor (NGF) protects neurons from death, prolonging survival of neurons in both the central and peripheral nervous systems. It is theorized that aging of the central nervous system is associated with a loss of NGF. ALC has shown the ability to reverse age-related decrease in the binding of NGF to its receptors in neuron membranes.14 Given to aged rats, ALC increases the level and utilization of NGF in the rats. ALC protects cholinergic neurons (nerve cells stimulated by acetylcholine) in rats from degeneration due to lack of NGF.15 These results, together with other data from animal studies, suggest that ALC positively influences NGF activity.16

Has a protective influence on brain neurons*

Several animal studies have revealed that ALC exerts a protective effect on neurons. In one experiment, brain cells from rats exposed to NMDA, a known neurotoxin, were protected by being simultaneously exposed to ALC.17 Rats injected with ALC were protected from mortality caused by the neurotoxin MPP+.18 ALC has been shown to raise levels of glutathione, a highly valuable antioxidant, in isolated mouse brain tissue.19 ALC prevents buildup of malondyhaldeyde, a marker of lipid peroxidation.20 ALC is also a chelator of iron, which can generate free radicals. It also reinforces antioxidant mechanisms in the brain.21 As a whole, data from test tube and animal studies, showing that ALC has a protective, restorative effect on brain neurons and neuronal energetic processes, suggest that ALC is an anti-aging nutrient for the brain. This hypothesis is supported by human studies demonstrating measurable benefits for brain function in elderly persons taking ALC by oral consumption.


Safety
Suggested Adult Use: 1 to 4 capsules daily.
ALC is considered safe and well-tolerated when consumed orally. ALC has been administered in doses as high as 3 grams per day for periods of two to six months, with no reports of serious side effects. Some patients have experienced occasional mild abdominal discomfort, nausea, skin rash, restlessness, vertigo and headache. The severity and incidence of these side effects are reported as minor.22

Scientific References
1. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
2. Salvioli, G. Neri , M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exptl. Clin. Res. 1994; 20(4):169-76.
3. Tempesta, E, et al. L-acetylcarnitine in depressed elderly subjects. A cross-over study vs. placebo. Drugs Exptl. Clin. Res. 1987;8(7):417-23.
4. Spagnoli, A et al. Long-term acetyl-L-carnitine treatment in Alzheimer's disease. Neurology 1991;41:1726-32.
5. Rai, G et al. Double-blind, placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's dementia. Curr. Med Res. Opin. 1990;11:638-47.
6. Falchetto, S, Kato, G, Provini, L. The action of carnitines on cortical neurons. Can J Physiol Pharmacol 1971; 49(1):1:7.
7. Dolezal, V., Tucek, S. Utilization of citrate, acetylcarnitine, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain slices. J Neurochem 1981;36(4):1323.30.
8. Passeri, M, et al. Mental impairment in aging: selection of patients, methods of evaluation and therapeutic possibilities of acetyl-L-carnitine. Int. J. Clin. Pharm. Res. 1988;8(5):367-76.
9. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
10. Parnetti, L, et al. Pharmacokinetics of IV and oral acetyl-L-carnitine in multiple dose regimen in patients with senile dementia of Alzheimer type. Eur. J. Clin Pharmacol 1992;42:89-93.
11. Pettegrew, JW, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiology of Aging 1995;16(1):1-4.
12. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
13. Arduni, A, et al. Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability. Life Sci 1990;47(26):2395-2400.
14. Taglialatela, G, et al. Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine. Biochem Pharmacol 1992;44(3):577-85.
15. Taglialatela, G, et al. Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp Gerontol 1994;29(1):55-56.
16. Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
17. Forloni, G, Angeretti, N, Smiroldo, S. Neuroprotective activity of acetyl-L-carnitine: studies in vitro. J Neurosci Res 1994;37(1):92-6.
18. Steffen, V, et al. Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine. Hum Exp Toxicol 1995;14(11):865-71.
19. Fariello, RG, et al. Systemic acetyl-L-carnitine elevates nigral levels of glutathione and GABA. Life Sci 1988;43(3):289-92.
20. Calvani, M, et al. Action of acetyl-L-carnitine in neurodegeneration and Alzheimer's disease. Ann Ny Acad Sci 1992;663:483-86.
21. Calvani, M, Carta, A. Clues to the mechanism of action of acetyl-L-carnitine in the central nervous system. Dementia 1991;2:1-6.
22. Zdanowicz, M. Acetyl-L-carnitine's healing potential. Continuing Education Module. New Hope Institute of Retailing. October, 2001.


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The Free Radical Theory
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Date: December 14, 2005 12:11 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Free Radical Theory

The popular theory has been the subject of a great deal of research. Developed by Denham Harman, M.D., Ph.D., at the University of Nebraska in 1956, the free radical theory proposes that unstable molecules known as free radicals are responsible for inflicting extensive cellular damage, which causes cell death and dysfunction and eventually, disease. The most common type of free radicals are oxygen derived, and free radical damage is often referred to as oxidation.

Environmental sources of free radicals include radiation (I.E., sun exposure, X-rays), ozone and nitrous oxide, heavy metals (i.e., mercury, cadmium, lead), smoke, alcohol, saturated fat, and other chemicals and pollutants. The body itself generates free radicals in performing essential bodily functions including energy production and immune activities. Fortunately, the body also has the ability to create antioxidants to neutralize the free radicals and prevent extensive cellular damage. When free radicals are not neutralized by antioxidants, they inflict large-scale cellular damage which can cascade and lead to age-related degenerative diseases such as osteoarthritis, osteoporosis and age –relaged macular degeneration. For example, free radical damage to joint cells may cause the cartilage to become rough or break down, and can lead to the development of osteoarthritis. Antioxidants are needed to comb at free radicals and prevent this cellular damage. “Oxidative stress can lead to DNA mutations, cell death, and disease, all of which contribute to aging,” said Gerald R. Cysewski, president and chief executive officer (CEO) at Cyanotech corp. “Antioxidants are produced naturally by the body to combat oxidative stress by neutralizing free radicals. Increasing the amount of antioxidants in one’s system by consumption of supplements can provide further protection from the damaging effects of free radicals.”

Because the body is continually assaulted by free radicals, antioxidant supplementation is often necessary. “by taking certain nutrients that our bodies stop producing over time, supplements help us to maintain a youthful look and health, which in turn enhances the quality of life,” Alkayali said. “Furthermore, supplements can help decrease oxidative stress that may otherwise accompany age-related illness and disease.”

Many Substances are known antioxidants including certain enzymes, vitamins, phytochemicals and minerals, and include Vitamin C, Vitamin E, alpha-lipoic acid, coenzyme Q10 (CoQ10), Carotenoids, Selenium, superoxide dismutase, melatonin, quercetin, catechins, and zinc.

Consuming a diet high in plant sources of powerful antioxidants is an important step to deter ageing, because nutrients from foods are often highly bioavailable and can act synergistically to increase their health benefits. Garlic contains several antioxidant phytochemicals and minerals including allicin, beta-carotene, quercetin, selenium and zinc, and may have a protective effect against stomach and colorectal cancers.

Catechins are potent antioxidants flavonoids, with the best known source being green tea; they include gallocatechin (GC), epigallocatechin (EGC), epicatechin (EC) and epigallocatechin gallate (EGCG). These antioxidants are being studied for their powerful abilities to combat free radical damage. In particular, EGCG has been researched for its reported protection against certain cancers and Alzheimer’s disease.

Green Foods such as seaweed, sea vegetables, young grain grasses and shoots, broccoli, cabbage and other green leafy vegetables pack a nutritional punch due to their concentratged amounts of antioxidant carotenoids, vitamins and the enzyme superoxide dismutase (SOD). SOD is produced by the body and neutralizes free radicals known as superoxide radicals, which cause damaging fat oxidation. GliSODin is a patented form of SOD derived from cantaloupe and bound to a wheat protein for superior bioavailability. “GliSODin promotes the body’s production of its own endogenous antioxidants, including SOD, catalase and glutathione peroxidase, in virtually every cell,” said Eric Anderson, brand manager at P.L. Thomas. “This activation of the cellular antioxidant defenses across the whole body creates a state of alertness against any shock of oxidative stress, including sun rays, to which our body may be exposed.”

Pomegranates contain two powerful antioxidants—ellagic acid, derived from fruit’s seeds, and punicaligans, found in the juice. “Research has shown that the juice from the pomegranate, rich in polyphenols, reduces oxidative stress by helping to produce enzymes to fight free radicals,” Alkayali said. NeoCell Corp. manufactures of ellagic-acid based Pomegranate Power, while P.L. Thomas supplies POM40p, a kosher-free pomegranate juice extract standardized to 40-precent punicocides, polyphenols belong to the punicalagin family.

Consumer demand is on the rise for products that address degenerative health conditions, including supplements that support function of the bones, joints, eyes. According to a June 2005 report by the freedonia group, “Bone and joint care products will continue to dominate the health maintenance segment, spurred by a growing customer base and a plethora of new and improved products expected to soon enter the marketplace.” The report also projected rapid gains for vision care. “Demand for vision care products will be propelled by aging baby boomers who are becoming aware of debilitating eye conditions and seeking both preventive measures and ameliorative treatments.” Dietary Supplements can help prevent and ease symptoms of age-related diseases affecting the joints, bones and eyes, including osteoarthritis, osteoporosis and age-related macular degeneration (AMD).



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Benefits of Alpha Lipoic Acid
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Date: October 13, 2005 05:08 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Alpha Lipoic Acid

Benefits of Alpha Lipoic Acid

  • Supports the Body’s Defense Against Free Radicals*
  • Recycles Antioxidant Nutrients such as Vitamin C and Vitamin E*
  • Helps Maintain a Healthy Blood Sugar Level when used as part of the diet*

    Alpha-lipoic Acid––the "Ideal Antioxidant"

    The antioxidant potential of a substance is based on a number of criteria, including:
    1) Ability to quench specific free-radicals.
    2) Ability to bind or "chelate" metal ions that can generate free radicals.
    3) Supports function of other antioxidants.
    4) Absorption/bioavailability.
    5) Concentration in tissues, cells and extra cellular fluids.
    6) Ability to function as an antioxidant in fatty and watery environments.

    The "ideal antioxidant" would meet all the above criteria. Very few antioxidants do, yet a particular antioxidant with but a few of the characteristics is still valuable and effective. Vitamin E, for example, is one of the most important dietary antioxidants, yet it only works in fatty environments such as cell membranes.

    As a team, ALA and DHLA come close to the ideal, for the following reasons:1,2,3
    1) ALA is easily absorbed when consumed orally.
    2) ALA is readily converted to DHLA in various tissues.
    3) As a pair, ALA and DHLA neutralize superoxide, hydroxyl, peroxyl, and hypochlorus radicals.
    4) ALA and DHLA form stable complexes with metal ions such as iron, manganese, copper and zinc ions.
    5) ALA and DHLA scavenge free radicals in fatty environments and watery environments.
    6) DHLA recycles other important antioxidants.

    DHLA-regenerates vitamin C, vitamin E and glutathione

    Within the cell, antioxidants work as a team to keep free radicals from damaging cell structures. In order to neutralize a free radical, an antioxidant such as vitamin C must give up an electron, which mean it becomes oxidized. Before it can function as an antioxidant once again, it must be regenerated back to its "reduced" form, by gaining an electron to replace the donated electron. For this, it needs the help of other antioxidants. Vitamin C, vitamin E and glutathione are key antioxidants that can be generated by cycling between their oxidized and reduce forms. This is necessary to maintain the balance between oxidation and its reverse––the neutralization of free radicals by antioxidants.

    DHLA is an essential component in the interaction between these antioxidants.4 Studies show that addition of alpha-lipoic acid to liver tissues results in increased vitamin C levels. It has been found that DHLA is responsible for regenerating vitamin C, which in turn regenerates vitamin E.3 DHLA also converts glutathione from its oxidized form back into its free radical scavenging reduced form.3,5 The ALA/DHLA pair is thus vital for prevention of "oxidative stress," which occurs which the balance is tipped in favor of oxidation in cells.4 DHLA helps preserve antioxidants in both the watery cell interior and the fatty structure of cell membranes.6 Evidence from animal studies suggests that DHLA protects the brain against free radical damage.7

    Alpha-lipoic Acid and Blood Sugar

    Alpha-lipoic acid is a key factor in the cellular process that metabolizes glucose to produce energy for cellular functions. The importance of ALA’s role in blood sugar metabolism is evidenced in studies on ALA and type-2 diabetes. In a small pilot study, 13 people with type-2 diabetes showed improved utilization of glucose in muscle tissue in response to intravenous administration of ALA.8 In a four week controlled multicenter trial, 74 people with type-2 diabetes took ALA in oral doses of 600, 1200 or 1800 mg per day. After 4 weeks, the normal lowering of blood sugar levels in response to insulin improved.9 In vitro studies have shown that ALA has a positive effect on insulin-stimulated uptake of glucose by muscle cells.10

    Scientific References

    1. Packer, L.. Witt, E., Tritschler, H. Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine 1995;19(2):227-50.

    2. Suzuki, Y., et al. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comms. 15(5):255-63.

    3. Biewenga, G., Haenen, G., Bast, A. The pharmacology of lipoic acid. Gen. Pharmac. 29(3):315-31.

    4. Serbinova, E. Maitra, I., Packer, L. The synergy between vitamin E and alpha-lipoic acid--–possible relationship against oxidative stress in vivo. Life Chemistry Reports 1994;12:17-21.

    5. Bast, A. Haenen, G. Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochimica et Biophysica Acta 1988; 963:558-561.

    6. Kagan, V. et al. Dihydrolipoic acid––a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44(8):1637.

    7. Prehn, J. et al. Dihydrolipoate reduces neuronal injury after cerebral ischemia. J Cereb Blood Flow Metab 1992;12(1):78-87.

    8. Jacob, S. et al. Enhancement of glucose disposal in patients with type-2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45(8):872-4.

    9. Jacob, S et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology & Medicine 1999;27(3/4):309-14.

    10. Estrada, D. et al. Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathway. Diabetes 1996;45(12):1798-804.



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    TopPreviousNext

    Date: October 06, 2005 10:08 PM
    Author: Darrell Miller (dm@vitanetonline.com)

    Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance [1].

    Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium [2]. An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake [3]. Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds.

    An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards" [4]. The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups [5]. Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium [6].

    In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body [7]. It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys [8].

    Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium [9]. Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium.

    Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28 [10]. The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA.

    Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements.

    Magnesium-the Versatile Mineral

    The average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes."

    Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP [11]. ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds".

    Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles [12].

    Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat [13]. Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress [14]. This has been found true even in the absence of an actual magnesium deficit in the body.

    Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density [15]. The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men [16]. In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency [17]. While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly.

    Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes [18].

    A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure.

    Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption [19]. Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide [20].

    Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996 [21].

    Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine® [22].

    Scientific References 1. Abbott, L.R., R., Clinical manifestations of magnesium deficiency. Miner electrolyte Metab, 1993. 19: p. 314-22. 2. Durlach, J., Recommended dietary amounts of magnesium: Mg RDA. Magnesium Research, 1989. 2(3): p. 195-202. 3. Morgan, K.e.a., Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition, 1985. 4: p. 195-206. 4. Windham, C., Wyse, B., Hurst, R. Hansen, R., Consistency of nutrient consumption patterns in the United States. J AM Diet Assoc, 1981. 78(6): p. 587-95. 5. Pennington, J., Mineral content of foods and total diets: the Selected Minerals in Food Survey, 1982 to 1984. J AM Diet Assoc, 1986. 86(7): p. 876-91. 6. Marier, J., Magnesium Content of the Food Supply in the Modern- Day World. Magnesium, 1986. 5: p. 1-8. 7. Costello, R., Moser-Veillon, P., A review of magnesium intake in the elderly. A cause for concern? Magnesium Research, 1992. 5(1): p. 61-67. 8. Durlach, J., et al., Magnesium status and aging: An update. Magnesium Research, 1997. 11(1): p. 25-42. 9. Seelig, M., Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnesium Research, 1990. 3(3): p. 197-215. 10. Zive, M., et al., Marginal vitamin and mineral intakes of young adults: the Bogalusa Heart Study. J Adolesc, 1996. 19(1): p. 39-47. 11. McLean, R., Magnesium and its therapeutic uses: A review. American Journal of Medicine, 1994. 96: p. 63-76. 12. Graber, T., Role of magnesium in health and disease. Comprehensive Therapy, 1987. 13(1): p. 29-35. 13. Sueta, C., Patterson, J., Adams, K., Antiarrhythmic action of pharmacological administration of magnesium in heart failure: A critical review of new data. Magnesium Research, 1995. 8(4): p. 389- 401. 14. Classen, H.-G., Systemic stress, magnesium status and cardiovascular damage. Magnesium, 1986. 5: p. 105-110. 15. Stendig-Lindberg, G., Tepper, R., Leichter, I., Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Research, 1993. 6(2): p. 155-63. 16. Tucker, K., et al., Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr, 1999. 69(4): p. 727-736. 17. Heroux, O., Peter, D., Tanner, A., Effect of a chronic suboptimal intake of magnesium on magnesium and calcium content of bone and bone strength of the rat. Can J. Physiol. Pharmacol., 1975. 53: p. 304-310. 18. Pineda, O., Ashmead, H.D., Effectiveness of treatment of irondeficiency anemia in infants and young children with ferrous bisglycinate chelate. Nutrition, 2001. 17: p. 381-84. 19. Adibi, A., Intestinal transport of dipetides in man: Relative importance of hydrolysis and intact absorption. J Clin Invest, 1971. 50: p. 2266-75. 20. Ashmead, H.D., Graff, D., Ashmead, H., Intestinal Absorption of Metal Ions and Chelates. 1985, Springfield, Illinois: Charles C. Thomas. 21. NNFA definition of mineral amino acid chlelates, in NNFA Today. 1996. p. 15. 22. Bioperine-Nature's Bioavailability Enhancing Thermonutrient. 1996, Sabinsa Corporation: Piscataway, N.J.

    *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

    Doctor's Best•1120 Calle Cordillera•Suite 101, San Clemente, CA 92673



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    Curcumin - Turmeric Extract
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    Date: August 19, 2005 12:47 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Curcumin - Turmeric Extract

    Curcumin

    Turmeric- History and Traditional Usage

    Native to Southeast Asia, Curcuma longa is a tall
    tropical shrub with large oblong leaves and pale yellow flowers.
    The genus “Curcuma” belongs to the Zingiberaceae family, which
    includes ginger.1 The plant possesses a large root structure
    with fleshy, bulbous underground parts called “rhizomes.” These
    rhizomes, known as turmeric root, are harvested at maturity,
    dried and cured for commercial use. Chemical analysis shows that
    dried turmeric contains essential and volatile oils, with a
    curcuminoid content of 2.5 to 5.0 %.2

    In addition to its
    popularity as a spice, turmeric is used as a dye for cloth and
    coloring agent in foods and cosmetics, thanks to its rich yellow
    color. Turmeric also serves as a preservative, probably owing to
    the antioxidant and antimicrobial properties of curcumin.
    Extracts of Curcuma longa have demonstrated in vitro
    antibacterial and anti-fungal effects.3

    Turmeric is named in
    ancient Ayurvedic and Chinese herbal texts as a traditional folk
    remedy. Historically, turmeric was used externally for wounds,
    and sprains, and internally for digestive complaints,
    rheumatism, liver disorders, coughs and colds.4
    Benefits

    Protects cells and tissues by fighting free radicals.*

    Supports joint function*

    The numerous beneficial
    effects attributed to turmeric stem in large measure from the
    antioxidant properties of curcumin. Antioxidants neutralize free
    radicals, which are highly unstable molecules that can damage
    cellular structures through abnormal oxidative reactions.
    Curcumin is a potent “scavenger” of the superoxide radical, a
    free radical that initiates potentially harmful oxidative
    processes such as lipid peroxidation.5 Through this activity,
    curcumin has been shown to protect skin cells from the injurious
    effect of nitroblue tetrazolium, a toxin that generates
    superoxide radicals. Curcumin also increases survival of cells
    exposed in vitro to the enzyme hypoxanthine/xanthine oxidase,
    which stimulates superoxide and hydrogen peroxide production.
    Curcumin itself is not toxic to cells, even at high
    concentrations. Pure curcumin was shown to be less protective
    than a mixture of curcuminoids, indicating a possible synergism
    among curcuminoids.6 Because free radicals are involved in aging
    and exert harmful effects on skin, these results suggest
    curcumin may help slow skin aging.

    Curcumin demonstrates
    several other in vitro effects linked to free radical
    scavenging. Curcumin scavenges nitric oxide, a compound
    associated with the body’s inflammatory response.7 Pure curcumin
    and turmeric extracts protect red blood cells from lipid
    peroxidation induced by hydrogen peroxide.8 Curcumin has been
    shown to protect DNA from oxidative damage, inhibit binding of
    toxic metabolites to DNA, and reduce DNA mutations in the Ames’
    test.9 Although additional studies suggest an anticarcinogenic
    effect of curcumin, through protection of DNA,10 one in vitro
    study found that curcumin induced DNA damage in human gastric
    mucosal cells.11 It is speculated that curcumin may act as a
    pro-oxidant in the presence of transition metal ions such as
    copper and iron. (This is true for other antioxidants, including
    vitamin C.) Curcumin also demonstrates in vitro inhibition of
    COX-I and COX-II enzymes, which are involved in the inflammatory
    reaction.12 Together these results strongly suggest that
    curcumin is a potent bioprotectant with a potentially wide range
    of therapeutic applications.

    Animal studies- In vivo protective effects

    Through its free radical scavenging
    properties, curcumin has shown bioprotective effects in animals.
    In one study, rats were treated with isoproterenol, a chemical
    that causes cardiac hypertrophy (enlargement of the heart) due
    to abnormal collagen metabolism. Co-treatment with curcumin
    reversed the degradation of collagen and cardiac hypertrophy
    induced by isoproterenol.13 Curcumin protects mice from
    detrimental effects of radiation, by stabilizing the glyoxalase
    system, a biological system that regulates cell division.14
    Curcumin protects livers of rats from the damaging effects of
    carbon tetrachloride (CCl4), a potent hepatoxin that injures the
    liver via its free radical metabolite, CCl3.15,16 Curcumin
    protected rats from alcohol-induced brain damage, in a study in
    which oral administration of curcumin reversed lipid
    peroxidation, reduced levels of free-radical metabolites and
    increased levels of glutathione, a major physiologic
    antioxidant.17 Curcuma longa extracts have shown
    anti-inflammatory effects in rats.18

    Human Trials

    Curcumin exhibits free-radical scavenging ability when
    administered to humans. In an open trial (uncontrolled), 18
    healthy individuals ranging in age from 27 to 67 years consumed
    a Curcuma longa extract, at a dose supplying 20 mg curcuminoids,
    for 45 days. Before and after blood tests showed a statistically
    significant decrease in lipid peroxides.19 Preliminary trials
    have tested the anti-inflammatory action of curcumin, with
    results that verify the traditional use of turmeric as an
    anti-rheumatic herb. In a short-term double-blind, cross-over,
    comparative study, 18 people received curcumin (1200 mg daily)
    or phenylbutazone for two week periods. Both curcumin and
    phenylbutazone produced measurable improvements in joint
    flexibility and walking time. The subjects reported results only
    with phenylbutazone, which may be explained by the short
    duration of the trial.20 In a small placebo-controlled trial
    comparing curcumin to phenylbutazone, 45 patients with
    post-operative inflammation received curcumin, phenylbutazone or
    placebo. The anti-inflammatory effects of curcumin and
    phenylbutazone were comparable and superior to placebo.21
    Curcumin has not been found to produce an analgesic (pain
    relieving) effect.

    Bioperine-Nature’s Absorption Enhancer
    Boosts Curcumin Absorption*

    Traditional Ayurvedic herbal
    formulas often include black pepper and long pepper as
    synergistic herbs. The active ingredient in both black pepper
    and long pepper is the alkaloid, piperine. Experiments carried
    out to evaluate the scientific basis for the use of peppers have
    shown that piperine significantly enhances bioavailability when
    consumed with other substances.22 Several double-blind clinical
    studies have confirmed that Bioperine® increases absorption of
    nutrients.23

    Curcumin is poorly absorbed in the intestinal
    tract, limiting its therapeutic effectiveness. Oral doses are
    largely excreted in feces, and only trace amounts appear in the
    blood. Concomitant administration of 20 mg of piperine with 2
    grams of curcumin increases the bioavailability of curcumin by
    2000%.24

    Scientific References


    1. Majeed, M., Badmaev,
    V., Shivakumar, U., Rajendran, R. Curcuminoids. 1995.
    Piscataway, NJ: NutriScience Publishers.
    2. Srimal, R.C.
    Turmeric: a brief review of its medicinal properties.
    Fitoterapia 1997;68(6):483-93.
    3. Ammon, H.P.T., Wahl, M.A.
    Pharmacology of Curcuma longa. Planta Medica 1991;57:1-7.
    4.
    Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae).
    The Protocol Journal of Botanical Medicine, Autumn
    1995:43-46.
    5. Rao, N.S., Rao, M.N.A. Free radical scavenging
    activity of curcuminoids. Arzneim.-Forsch./Drug Res.
    1996;46(2):169-171.
    6. Bonté. F. et al. Protective effect of
    curcuminoids on epidermal skin cells under free oxygen radical
    stress. Planta Medica 1997;63:265-66.
    7. Rao, S., Rao, M.N.A.
    Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol.
    1997;49:105-7.
    8. Lalitha, S., Selvam, R. Prevention of
    H2Os-induced red blood cell lipid peroxidation by aqueous
    extracted turmeric. Asia Pacific J Clin Nutr
    1999;8(2):113-14.
    9. Deshpande, S.S., Maru, G.B. Effects of
    curcumin on the formation of benzo[a]pyrene derived DNA adducts
    in vitro. Cancer Letters 1995;96:71-80.
    10. Subramanian, M., et
    al. Diminution of singlet oxygen-induced DNA damage by curcumin
    and related antioxidants. Mutation Research
    1994;311:249-55.
    11. Blasiak, J., Trzeciak, A., Kowalik, J.
    Curcumin damages DNA in human gastric mucosa cells and
    lymphocytes. Journal of Environmental Pathology, Toxicology and
    Oncology 1999;18(4):271-76.
    12. Ramsewak, R.S., DeWitt, D.L.,
    Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory
    activities of Curcumins I-III from Curcuma longa. Phytomedicine
    2000;7(4):303-308.
    13. Nirmala, C. Anand, S., Puvanakrishnan,
    R. Curcumin treatment modulates collagen metabolism in
    isoproterenol induced myocardial necrosis in rats. Molecular and
    Cellular Biochemistry 1999;197:31-37.
    14. Choudhary, D.,
    Chandra, D. Kale, R.K. Modulation of radioresponse of glyoxalase
    system by curcumin. Journal of Ethnopharmacology
    1999;64:1-7.
    15. Park, E-J. et al. Protective effect of
    curcumin in rat liver injury induced by carbon tetrachloride. J
    Pharm. Pharmacol. 2000;52:437-40.
    16. Deshpande, U.R. et al.
    Protective effect of turmeric (Curcuma longa L.) extract on
    carbon tetrachloride-induced liver damage in rats. Indian
    Journal of Experimental Biology 1998;36:573-77.
    17.
    Rajakrishnan, V. et al. Neuroprotective role of curcumin from
    Curcuma longa on ethanol-induced brain damage. Phytotherapy
    Research 1999;13:571-74.
    18. Arora, R.B. Basu, N., Kapoor, V.,
    Jain, A.P. Anti-inflammatory studies on Curcuma longa
    (Turmeric). Indian J Med Res 1971;59(8):1289-95.
    19.
    Ramirez-Bosca, A. et al. Antioxidant curcuma extracts decrease
    the blood peroxide levels of human subjects. Age
    1995;18:167-69.
    20. Deodhar, S.D., Sethi, R. Srimal. R.C.
    Preliminary study on antirheumatic activity of curcumin
    (diferoyl methane). Indian J Med Res 1980;71:632-34.
    21.
    Satoskar, R.R., Shah, S J. Shenoy, S.G. Evaluation of
    anti-inflammatory property of curcumin (diferoyl methane) in
    patients with postoperative inflammation. International Journal
    of Clinical Pharmacology, Therapy and Toxicolgy
    1986;24(12):651-54.
    22. Atal, C., Zutshi, U., Rao, P.
    Scientific evidence on the role of Ayurvedic herbals on
    bioavailability of drugs. Journal of Ethnopharmacology
    1981;4:229-232.
    23. Bioperine®–Nature's Bioavailability
    Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa
    Corporation, Piscataway, N.J.
    24. Shoba, G., et al. Influence
    of piperine on the pharmacokinetics of curcumin in animals and
    human volunteers. Planta Medica 1998;64(4):353-6.

    © 2002
    Doctor's Best, Inc. Revised 8/13/02

    *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



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    ENADA® NADH 5mg - NEW PRODUCT ANNOUNCEMENT
    TopPreviousNext

    Date: August 03, 2005 05:23 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: ENADA® NADH 5mg - NEW PRODUCT ANNOUNCEMENT

    NEW PRODUCT ANNOUNCEMENT

    ENADA® NADH 5mg

    Energy-Rich Coenzyme—Convenient 60-tab Size!

  • •Essential for the production of ATP, the primary energy carrier in our cells.
  • •The brain, nerves, muscles and heart require a constant supply of ATP energy in order to function.
  • •NADH regenerates the powerful antioxidants CoQ10 and alpha-lipoic acid.
  • •Source Naturals uses ENADA®, the only patented, stabilized, absorbable form of NADH available.

    1 tablet contains:
    NADH (Reduced ß-Nicotinamide Adenine Dinucleotide) 5 mg

    Suggested Use: 1 tablet daily in the morning, on an empty stomach, with water. Wait 30 minutes before eating. Or, take as recommended by your health care professional.



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    Benfotiamine raises the blood level of thiamine pyrophosphate (TPP)
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    Date: August 02, 2005 03:52 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Benfotiamine raises the blood level of thiamine pyrophosphate (TPP)

    Benefits

    Benfotiamine raises the blood level of thiamine pyrophosphate (TPP), the biologically active co-enzyme of thiamine.4

    Thiamine and its Co-enzyme, TPP

    Thiamine (vitamin B1) plays an essential part in the metabolism of glucose, through actions of it co-enzyme TPP (thiamine pyrophosphate). TPP is formed by the enzymatically-catalyzed addition of two phosphate groups donated by ATP to thiamine. TPP also goes by the name "thiamine diphosphate." In the cytoplasm of the cell, glucose, a 6-carbon sugar, is metabolized to pyruvic acid, which is converted into acetyl-CoA, otherwise known as "active acetate." Acetyl CoA enters the mitochondrion, where it serves as the starting substrate in the Kreb’s cycle (citric acid cycle). The Krebs cycle is the primary source of cellular metabolic energy. TPP, along with other co-enzymes, is essential for the removal of CO2 from pyruvic acid, which in turn is a key step in the conversion of pyruvic acid to acetyl CoA. CO2 removal from pyruvic acid is called "oxidative decarboxylation," and for this reason, TPP was originally referred to as "cocarboxylase." TPP is thus vital to the cell’s energy supply. Benfotiamine helps maintain healthy cells in the presence of blood glucose. Acting as a biochemical "super-thiamin," it does this through several different cellular mechanisms, as discussed below.

    Benfotiamine and Glucose Metabolism Benfotiamine normalizes cellular processes fueled by glucose metabolites.

    As long as glucose remains at normal levels, excess glucose metabolites do not accumulate within the cell. The bulk of the cell’s glucose supply is converted to pyruvic acid, which serves as substrate for production of acetyl CoA, the primary fuel for the Krebs cycle. Of the total amount of metabolic energy (in the form of ATP) released from food, the Krebs cycle generates about 90 percent.5 In the presence of elevated glucose levels, the electron transport chain, the final ATP-generating system in the mitochondrion, produces larger than normal amounts of the oxygen free radical "superoxide." This excess superoxide inhibits glyceraldehyde phosphate dehydrogenase (GAPDH), as key enzyme in the conversion of glucose to pyruvic acid, resulting in an excess of intermediate metabolites known as "triosephosphates." Increase triosephophate levels trigger several cellular mechanisms that result in potential damage to vascular tissue. Cells particularly vulnerable to this biochemical dysfunction are found in the retina, kidneys and nerves.

    Benfotiamine has been shown to block three of these mechanisms: the hexosamine pathway, the diaglycerol-protein kinease C pathway and the formation of Advanced Glycation End-poducts. As discussed below, benfotiamine does this by activating transketolase, a key thiamin-dependent enzyme.6 Benfotiamine stimulates tranketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.* Transketolase diverts the excess fructose-6-phosphate and glyceraldehydes-3-phosphate, (formed by the inhibition of GAPDH, as mentioned above), into production of pentose-5-phosphates and erythrose-4-phosphate and away from the damaging pathways. Benfotiamine activates transketolase activity in bovine aortic endothelial cells incubated in glucose.6 To test benfotiamine’s ability to counteract these metabolic abnormalities caused by elevated blood glucose, studies have been done in diabetic rats. Benfotiamine increases transketolase activity in the retinas of diabetic rats, while concomitantly decreasing hexosamine pathway activity, protein kinase C activity and AGE formation.6

    Benfotiamine and Protein glycation Benfotiamine controls formation of Advanced Glycation End-products (AGEs).

    AGEs have an affinity for proteins such as collagen, the major structural protein in connective tissue. AGEs are formed through abnormal linkages between proteins and glucose. This occurs via a non-enzymatic glycosylation reaction similar to the "browning reaction" that takes place in stored food.7 At high glucose concentrations, glucose attaches to lysine, forming a Schiff base, which in turn forms "early glycosylation products." Once blood glucose levels return to normal levels, the amount of these early glycosylation products decreases, and they are not particularly harmful to most tissue proteins. On long-lived proteins such as collagen, however, early glycosylation products are chemically rearranged into the damaging Advanced Glycation End-products. AGE formation on the collagen in coronary arteries causes increased vascular permeability. This vessel "leakiness" allows for abnormal cross-linking between plasma proteins and other proteins in the vessel wall, comprising vascular function and potentially occluding the vessel lumen. A number of other potentially harmful events may also occur, including production of cytokines that further increase vascular permeability. Endothelin-1, a strong vasoconstrictor, is over produced, increasing the possibility of thrombosis and generation of oxygen free radicals is stimulated.8 It is vitally important to support normal glucose metabolic pathways so that formation of AGEs is minimized. Benfotiamine, in the test tube (in vitro) prevents AGE formation in endothelial cells cultured in high glucose by decreasing the glucose metabolites that produce AGEs.9 Endothelial cells make up the membranes that line the inner walls of organs and blood vessels. In a rat study comparing the effects of Benfotiamine with water-soluble thiamin, Benfotiamine inhibited AGE formation in diabetic rats while completely preventing formation of "glycooxidation products," which are toxic by products of chronic elevated blood glucose. AGE levels were not significantly altered by thiamin.10 Benfotiamine also normalized nerve function in the animals. After three months of administration, "nerve conduction velocity (NCV)," a measure of nerve function, was increased by both benfotiamine and thiamin; at six months, NCV was normalized by benfotiamine, whereas thiamin produced no further increases in this parameter.

    Dysfunctional glucose metabolic pathways leading to AGE formation occurs in endothelial cells of the kidneys. In a recent animal study, benfotiamine was administered to rats with elevated glucose levels. Benfotiamine increased transketolase activity in the kidney filtration system of these rats, while at the same time shifting triosephophates into the pentose pathway and preventing protein leakage.11

    Safety

    Benfotiamine has an excellent tolerability profile and can be taken for long periods without adverse effects.3,12 The statements in this fact sheet have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

    Scientific References

    1. Bitsch R, Wolf M, Möller J. Bioavailability assessment of the lipophilic benfotiamine as compared to a water-soluble thiamin derivative. Ann Nutr Metab 1991;35(2):292-6.

    2. Schreeb KH, Freudenthaler S, Vormfelde SV, et al. Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate. Eur J Clin Pharmacol 1997; 52(4):319-20.

    3. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther 1996;34(2):47-50.

    4. Frank T, Bitsch R, Maiwald J, Stein G. High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfontiamine. Eur J Clin Pharmacol. 2000;56(3):251-7.

    5. Pike RL, Brown ML. Nutrition, An Integrated Approach, 3rd Ed. New York:MacMillan; 1986:467.

    6. Hammes H-P, Du X, Edlestein D, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic neuropathy. Nat Med 2003;9(3):294-99.

    7. Monnier VM, Kohn RR, Cerami A. Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Sci 1984;81(2):583-7.

    8. Brownlee M. The pathological implications of protein glycation. Clin Invest Med 1995;18(4):275-81.

    9. Pomero F, Molinar Min A, La Selva M, et al. Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose. Acta Diabetol 2001;38(3):135-8.

    10. Stracke H, Hammes HP, Werkman D, et al. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes 2001;109(6):300-6.

    11. Babaei-Jadidi R, Karachalias N, Ahmed N, et al. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes 2003;52(8):2110-20.

    12. Bergfeld R, MatsumaraT, Du X, Brownlee M. Benfotiamin prevents the consequences of hyperglycemia induced mitochondrial overproduction of reactive oxygen specifies and experimental diabetic neuropathy (Abstract) Diabetologia 2001; 44(Suppl1):A39.



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    VANADIUM W/CHROMIUM - Supports Healthy Blood Sugar Levels
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    Date: June 24, 2005 05:15 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: VANADIUM W/CHROMIUM - Supports Healthy Blood Sugar Levels

    Today’s sedentary lifestyles and sugar-rich, nutrient-poor foods are contributing to the rise of obesity in our society. The result: challenges to your body’s system of balancing blood sugar levels and insulin activity. Maintaining a healthy diet and lifestyle helps keep blood sugar levels in the normal range, but sometimes you need nutritional support when you don’t have time to make those healthy food choices. Source Naturals, the science company, introduces VANADIUMW/CHROMIUM for blood sugar support. Research shows that these two important minerals help maintain normal blood sugar levels when used as part of your diet.

    Vanadium works together with chromium to support healthy blood sugar levels. Research has shown that both of these important minerals play a key role in normal insulin function.

    Vanadium: Balances Insulin Activity Vanadium, named after Vanadis the Norse goddess of beauty, belongs to a group of biologically important metals known as transition elements. These metals have a natural tendency to form complexes with organic compounds called coordination compounds that serve important biological functions.

    Insulin is secreted by the pancreas in response to high blood glucose levels after meals. Without insulin, glucose cannot enter cells to provide fuel for cellular energy. The sugar that remains in the blood can create problems by binding with protein molecules, resulting in damaged, non-functioning structures, in a process called glycation. Some evidence suggests that vanadium supports these vital metabolic processes because of its ability to mimic the actions of insulin.

    More Absorbable Form of Vanadium

    Absorption of dietary vanadium and supplemental vanadium is poor. It is estimated that less than 5% of dietary vanadium is absorbed. Organic forms of vanadium, such as bis-glycinato oxovanadium or BGOV, are recognized as being more absorbable. BGOV is an organically bound, bioavailable form of vanadium complexed with the amino acid glycine. Glycine, an amino acid found in the protein of all life forms, generates superior vanadium absorption.

    Chromium: Supports Glucose Metabolism Chromium is a trace element the body needs in very small amounts, but it plays a significant role in human nutrition. Its most important function is to help regulate the amount of glucose in the blood. Insulin plays a role in this process, by regulating the movement of glucose out of the blood and into the cells. Chromium is a key constituent of the compound known as glucose tolerance factor (GTF). This mineral enhances the effectiveness of insulin, encouraging glucose to enter cells, where it can be burned for fuel.

    Chromium participates in glucose metabolism by enhancing the effects of insulin. Insulin binds to insulin receptors on the surface of cells, activating those receptors and stimulating glucose uptake by cells. Through its interaction with insulin receptors, insulin provides cells with glucose for energy and prevents blood glucose levels from becoming elevated. Glucose buildup in the bloodstream is associated with adverse changes in lipid profiles and increased challenges for cardiovascular health. Some studies examining the effects of chromium supplementation on lipid profiles have observed reduction in serum total cholesterol, LDL cholesterol, and triglyceride levels. Source Naturals VANADIUM W/CHROMIUM includes ChromeMate®, a patented compound of chromium and niacin with proven GTF activity.

    Wellness Nutrition

    Taking responsibility for your health is at the heart of the wellness revolution. Sometimes life may seem like it’s passing you by and you may not have time to focus on staying healthy. Your local health food outlet is a great resource for nutritional education and effective, advanced natural products. Source Naturals is pleased to partner with these outlets to bring you products like VANADIUM W/CHROMIUM to help you maintain a healthy balance.

    References:

    Anderson, R.1998. Chromium, glucose intolerance and diabetes. Journal of the American College of Nutrition 17(6):548-555. Jellin, J., et al. 2004. Vanadium Monograph. Pharmacists Letter/Prescribers Letter Natural Medicines Comprehensive Database. Therapeutic Research Facility. Nandhini, S., et al. 1993. Insulin-like effects of bis-glycinato oxovanadium complex on experimental diabetic rats. Indian Journal of Biochemistry and Biophysics 30:73-76.



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    What is the difference between the types of Ginseng?
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    Date: June 17, 2005 12:45 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: What is the difference between the types of Ginseng?

    What is the difference between the types of Ginseng?

    Ginseng has been used for thousands of years by the Chinese and Native Americans. The Chinese name, Ren Shen means "Man-Root" because it is shaped like a human. There have been over 3,000 scientific studies published on Ginseng. Studies have examined the anti-tumor, anti-infective, nervous system, lipid lowering, and anti-fatigue activity of ginseng. Experimental research indicates that Ginseng helps the body adapt to stress, protects the body against radiation, and increases sperm count, and stabilizes blood sugar levels.

    Ginseng can differ depending upon the species, the way it is prepared, and of course the dose administered. There are two main kinds of Ginseng: American and Asian. American Ginseng, Panax quinquefolium, grows wild in many states although it is cultivated mainly in Wisconsin. American Ginseng generates body fluids and is said to clear heat. Those who can benefit most from American Ginseng are individuals that are under stress, athletes, and people who feel hot and thirsty. They may also have coughing, or coughing up blood, which indicates heat according to traditional Chinese Medicine.

    Asian Ginseng, Panax Ginseng, is usually imported to the US from either China or Korea. It is traditionally used to treat cold syndromes, which include cold limbs, weak pulse, exhaustion, and shortness of breath. White Ginseng usually refers to untreated ginseng, and is said to be less warm than red Ginseng. Typically red Ginseng is steamed and cured with other herbs giving it a dark red appearance; most Korean Ginseng is red.

    A common substitute for Ginseng in the US and China is Codonopsis, known botanically as Codonopsis pilosula. It has similar effects to Asian Ginseng: it is not as strong and not nearly as expensive. Eleuthero Ginseng, sometimes referred to as Siberian Ginseng, is really not ginseng at all but is in fact a distant cousin. It belongs in a different botanical species: Eleutherococcus Senticosus. Eleuthero Ginseng grows in northern China and Russia. Although it is used to help the body adapt to stress, it is less specific as a medicinal herb than Asian or American Ginseng.

    Traditional herbalists rarely use ginseng by itself. Herbs are usually combined with other ingredients in order to increase clinical benefits and reduce negative reactions. For example, Generate Pulse Powder (Sheng Mai San) is a traditional combination, which often combines America Ginseng with herbs to moisten the lungs; therefore it can be used for chronic cough that is difficult to expectorate, and shortness of breathe. Bu Zhong Yi Qi Wan is an ancient formula that has been used for at least one thousand years to treat patients who are exhausted, feel cold, and may have weak limbs and/or chronic loose stools. In this ancient formula, Ginseng is combined with Astragalus and other harmonizing herbs, which help the body assimilate ginseng. Modern formulas with Ginseng or Codonopsis, have been used to help people overcome serious conditions such as impotence, Chronic Fatigue Syndrome, and fibromyalgia. Modern Ginseng formulas have also been used in conjunction with western medical approaches to treating patients with HIV, and patients undergoing chemo and radiotherapy.

    Asian Ginseng is considered a "big gun" and should not be indiscriminately used especially by itself. Headache, elevated body temperature, digestive upset, rash, fever, irritability, and insomnia are possible signs that Ginseng is not appropriate. It should not be taken at the same time as caffeine or other stimulants. Good quality Ginseng is expensive. Superior grade Ginseng can run several thousand dollars per pound. For this reason, it makes no sense to shop for the cheapest Ginseng or Ginseng products.



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    Ocean Treasures - For centuries, people have flocked to the sea....
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    Date: June 13, 2005 10:11 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Ocean Treasures - For centuries, people have flocked to the sea....

    Ocean Treasures by Chrystle Fiedler Energy Times, January 3, 2004

    For centuries, people have flocked to the sea to take advantage of its healing and restorative powers.

    "The ocean is alive with energy and abundant sea life," says Susie Galvez, owner of Face Works Day Spa in Richmond, Virginia and author of Hello Beautiful (MQ Publications). "It's an abundant source. Sea products are rich in minerals like magnesium, potassium, iron and zinc, all of which are known for their deeply cleansing and antibiotic properties. When we think of the sea, we think of health, invigoration, the feeling of being alive and yet peacefully calm."

    "To the ancient Greeks, the image of Aphrodite rising out of the sea was beautiful because of the nutrients that the sea plants had given her," says Linda Page, ND, in Healthy Healing (Healthy Healing Publications). Today, sea plants still provide beauty benefits. "They have a complete spectrum of chelated minerals, which makes them easier to absorb, that add lustre and shine to your hair and eyes and improve skin texture and tone."

    Thalassotherapy (seawater treatment) includes using salts, mud, foliage, sand and water from the sea to stimulate, hydrate and nourish the skin, making it smoother, firmer and more resilient.

    "Using sea products in treatments is both restorative and detoxifying," says Galvez. "Now with modern technology, you don't have to live anywhere near the sea to take advantage of the wonderful health and wellness benefits. Your sea retreat source can be as close as your health food store."

    Seaweed's Beauty Benefits

    "Pollution, stress, fatigue and bad eating habits all affect the body," says Anne Mok, LaC, a certified Chinese herbalist and co-owner of Cornerstone Healing in Brooklyn, New York. This leads to vitamin and mineral deficiencies that can result in broken capillaries, loss of firmness, skin lesions, dry scaliness and more.

    The good news, Mok says, is since seaweed is packed with easy-to-absorb proteins, vitamins, minerals and lipids, it can protect against environmental pollution and ward off aging by nourishing and moisturizing the skin. "The seawater in seaweed is similar to human plasma, so it's an ideal way to get the nutritive benefits from the sea, vitamins A, C and E, and the minerals zinc, selenium and magnesium we need through the process of osmosis. Seaweed cleanses, tones and soothes the skin and regenerates body tissues, offering a new vitality and helping to maintain a youthful appearance. It also improves circulation, which has a positive effect on local fatty overloads and helps maintain the tone of the tissue." No wonder seaweed is used to firm the skin and reduce the appearance of cellulite!

    Seaweed captures all the richness from the sea. "There is no genetic manipulation, fertilizer or pesticides, just the sea, light and the tides," says Mok. "[S]eaweed is ten times richer in trace elements than land plants."

    Beauty aids from the sea include:

    * Kelp (laminaria), a large leafy brown algae, grows along cold climate coastlines and can bring a healthy glow to skin. "Kelp powder has exfoliating properties that make it a great addition to a facial mask," Galvez adds. "It increases blood circulation and stimulates lymph production to eliminate toxins. It's also a mineral-rich body scrub for removing surface impurities."

    * Crushed algae is often used in seaweed masks.

    * Carrageenan, a gel extracted from Irish sea moss, is commonly used as a cosmetic thickening agent. "It's a great moisturizer that holds nutrients and water in," says Mok.

    * Bladderwrack (fucus), a brown seaweed, is often used in cellulite-reducing creams to eliminate excess fluid from the skin.

    A Seaweed Beauty Routine

    Incorporating the benefits of seaweed into your beauty routine is easy. You can "purchase dehydrated seaweed at a natural food store to make your bath a mini-ocean," says Janice Cox, author of Natural Beauty at Home (Henry Holt & Co). "Fill the tub to the point that you're covered when you lie down," says Dr. Page. "The idea is to make your body sweat, to open your pores, release toxins and take in the sea nutrient benefits by osmosis. Boost the effect with a few drops of aromatherapy bath oils like rosemary and lavender. It'll help hold the heat in and improve your cleansing program." Rinse off and "you'll feel your skin tighten, due to the high iodine content of the seaweed," says Cox. "Your skin should also feel softer and firmer."

    Seaweed and algae body wraps are ideal ways to beautify the skin, rid your body of toxins and boost well-being and health. "It starts a program of detoxification very rapidly," says Dr. Page, who has also written Detoxification: All You Need to Know (Healthy Healing Publications). "It's amazing how it encourages weight loss and cellulite reduction." "Seaweed wraps are the most effective cellulite treatments," says Mok. "Seaweed and seaweed mud, especially, stimulate the cells to improve cellular activity and increase the efficiency of lymphatic fluid, which helps break down toxic deposits that can result in cellulite.

    "It's excellent conditioning for the skin and leaves it soft and glowing," says Claudia Spagnolo, spa director for the DeFranco Spagnolo Salon and Day Spa in Great Neck, New York.

    Revitalize With Sea Salts

    Sea salts contain minerals-such as calcium, potassium, magnesium, sodium, iron, sulphur, phosphorus and chlorine-that have a delightfully rejuvenating and revitalizing effect on skin.

    "Sea salts enhance the youthful healthy glow of the skin," says Spagnolo. "It creates a deep pore cleansing from shoulder to toe, removing rough, dry skin, helping to purify and slough off dead skin cells. It's great for an all-over exfoliation, and leaves the skin smooth and refreshed."

    "Sea salt has wonderful drawing properties, promoting the removal of toxins from the skin," says Galvez, author of Ooh La La Effortless Beauty (MQ Publications). "It's high in mineral content and nourishes the body."

    Sea salt also "guards against moisture loss, so it's ideal for dry skin and helps prevent aging," says Mok. In addition, it can be used to treat acne, eczema and psoriasis. Often done before a massage in spas, a "salt glow," which uses a vigorous scrub of coarse sea salts mixed with essential oils, rejuvenates and revitalizes the skin. Sea salt is also readily available at health food stores so you can do the same at home.

    Mineral-rich Dead Sea salts pack a salinity of 32%. "When bathing with Dead Sea salt you don't even need to use soap because the minerals remove redundant fat and dirt," says Mok. Dead Sea minerals are often used in shampoos, conditioners and shower gels. "Galvez adds, "Dead Sea mud mineral and vitamin content is very close to that of humans, and therefore treatments using the mud penetrate deeply."

    Ah! Home Spa

    It's easy to turn your bathroom into an oasis of calm and create a private spa to call your own.

    For a sea cure bath, mix together half a pound of sea salt and a pound of baking soda, add to a warm water bath and soak until the water has cooled, says Mok. "It's excellent for soothing itchy and dry skin and helps detoxify by pulling out toxic waste from the pores." Aromatherapy oils, like lavender, make your soak in the tub even more relaxing and luxurious. "It's a great way to de-stress after a long day at work."

    A seaweed wrap can release water retention and leave legs looking their sleekest, notes Mok. "Just soak legs in a bath of warm water and Epsom salts for 5 minutes, then pat dry. Apply a seaweed mask and wrap legs with plastic wrap and a warm towel. Relax for 15 minutes. Remove towel and plastic wrap and rinse."

    You can also try a sea salt rub by mixing two cups of kosher salt with one cup of olive oil until it forms a thick paste. (Be careful: the oil is slippery.) "While in the tub or shower, massage it into your skin using long strokes toward the heart, starting with your feet," says Galvez. Rinse off with warm water, use a soft washcloth to remove any residue, pat dry and apply moisturizer. "Your skin will be silky smooth and wonderfully hydrated." To create a spa environment at home, details make all the difference. "Think of your favorite beach get-a-way and go with an ocean theme," says Cox. "Include something for each of the senses." For example, put on a CD that has nature sounds. To capture the color of the water, use sea-colored towels. For scent, light candles that produce the scents of flowering plants (such as plumeria or citrus). Add "ocean" fragrance beads. When taking a bath, "use shells to scoop out sea salts or dehydrated sea weed and put them around the tub as decoration," says Cox. Smooth on a moisturizer with a sea-scented lotion when you finish your spa treatment.

    When you make an at-home sea spa experience a regular part of your routine, you reap a bounty of beauty and health benefits. "In just 20 minutes you can have a mini-vacation," says Galvez. "It's cleansing and relaxing."

    Then you will be ready to dive back into reality with renewed zest.



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    Vitanet ®

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    Health Movements - Joining mind and body with healthy movement generates harmony
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    Date: June 12, 2005 05:49 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Health Movements - Joining mind and body with healthy movement generates harmony

    Health Movements by Sylvia Whitefeather Energy Times, December 6, 2003

    Mind/body exercises like yoga (especially the super-popular Bikram variety), tai chi and Pilates aren't just trendy, they're custom made to soothe the rough edges of modern life. So often does today's fast-paced world emphasize the mental and competitive aspects of existence that its inhabitants frequently neglect the necessity of gentle movement for the body. But these exercises are an antidote to the tendency to view the mind and body as separate entities.

    Modern science is validating what traditional teachers have always known: The mind dwells in every cell. Joining mind and body with healthy movement generates harmony, lowers your chance of chronic illness and promotes emotional stability.

    Yoga

    No one knows when yoga first appeared. Historians and archaeologists figure the practice was initiated in India somewhere between 3,000 and 1,500 BCE. But the father of the modern forms of yoga is considered to be a man named Patanjali, who wrote the Yoga Sutra around 200 CE.

    The literal translation of the word yoga is "union." As Jennifer Schwamm Willis notes in her book The Joy of Yoga (Marlowe), this practice represents "the union of body, mind and spirit." The purpose of learning the fundamental movements of yoga is to connect with your body, release knots of tension and improve strength and flexibility. In that way, the physical balance during a yoga session translates into inner balance during times of crisis or distress. Schwamm points out that ancient yoga practitioners believed "the aim of yoga is to quiet the fluctuations of the mind, to create stillness in order to hear one's inner voice..."

    Yoga is used by many for stress relief. But it has other important uses: In a study presented by Oregon Health & Science University at the American Academy of Neurology meeting in April 2003, yoga was shown to benefit folks with multiple sclerosis. The researchers found that participants who regularly attended yoga class for six months suffered less fatigue and improved their quality of life.

    A yoga class generally begins with warm-up postures, moves on to a core group of basic postures, and ends with poses meant to cool you down. An important aspect of yoga is breath work and control. Movement in and out of poses involves carefully orchestrated breath work. Inhalation and exhalation in timed sync with movement lies at the heart of yoga's benefits. Yoga beginners often feel stiff and inflexible. But with gentle, patient, regular practice, greater flexibility, strength and balance can be had. Experts say that a yoga session does not demand struggle; it asks for surrender. If one pose causes discomfort, try another.

    Bikram Yoga

    One particular form of yoga, Bikram, is hot in terms of both popularity and room temperature: Not only is it one of the biggest trends in the fitness world, this demanding, aerobic take on yoga is conducted in heated rooms designed to maximize muscle relaxation and minimize injury risk. The heat also helps facilitate cleansing and detoxification. It was created by Bikram Choudhury, a four-time Indian yoga champ who founded the Yoga College of India in Beverly Hills, California.

    As in other types of yoga, Bikram uses asanas, or poses, handed down through generations of yoga teachers. In this case, though, 26 asanas are done in a prescribed order over a 90-minute period. Everyone, from novice to expert, works out together, the idea being that each individual is working to stretch his or her own limits by becoming stronger, more flexible and less prone to illness.

    Bikram yoga stresses the tourniquet effect, in which blood floods through vessels after they've momentarily been squeezed shut. This pressurizing effect is supposed to flush out debris, quickening circulation and releasing stress. The tourniquet effect also helps cleanse the lymphatic system. Proponents say Bikram improves balance, concentration and posture; increases energy; and eases sleep.

    Like any other exercise program, Bikram yoga requires diligence: one center says a minimum of 10 classes over 30 days is needed for maximum benefits. And while hydration is important during all fitness routines, consuming adequate water is crucial when you're exercising in a hot room.

    Tai Chi

    Tai chi (also known as taiji or tai chi ch'uan) consists of a series of fluid movements that build endurance, increase flexibility and balance, and foster alertness of mind and spirit. Tai chi developed around the 13th century as a form of martial arts in China based on the power of flow and grace, rooting and yielding, flexibility and endurance. To the onlooker, a person practicing the movements of tai chi has the quality of someone swimming in air.

    This gentle form of movement can be practiced by people of almost all ages and physical conditions. Tai chi does not require special equipment, props or a floor mat. As a non-impact form of exercise, tai chi delivers minimal stress to the joints. Tai chi emphasizes proper body alignment and uses the large muscles in the legs to relieve stress from the hips, back and shoulders. It strengthens joints, increases range of motion and improves circulation of all body fluids. Like many other forms of mind/body exercise, tai chi relieves stress.

    Tricia Yu, author of Tai Chi: Mind and Body (DK), has been practicing tai chi for over 30 years. She believes that tai chi not only has benefits as a health exercise, but that it "can have a beneficial effect on your mental and emotional states, as well as help you to feel connected with your surroundings." Yu adds, "Like yoga, tai chi originated in a culture that views the mind and body not as separate but rather as different expressions or states of qi-vital energy or life force."

    Current research has validated the health benefits of tai chi. One study found that the knee strength of elderly people practicing tai chi improves significantly (J Gerontol A Biol Med Sci 2003 August; 58:M763-6). Participants in this study, whose average age was 72 years, benefited significantly after five months of tai chi. For the elderly, this extra strength and control translates into fewer falls and injuries.

    Tai chi may help immunity. In a study published in the September 2003 issue of Psychosomatic Medicine, researchers reported that elderly folks who participated in a tai chi class for a period of 15 weeks "saw an improvement in factors that suppress shingles [a painful viral condition] increase by 50%." They also showed an increased ability to move throughout the day and a significant improvement in their general health.

    Pilates

    Joseph Pilates (1880-1968) was a sickly child afflicted with asthma, rickets and rheumatic fever. Determined to recover his health, Pilates studied both Eastern and Western forms of exercise, incorporating moves from gymnastics, yoga and wrestling, along with controlled breathing. With his wife, Clara, Joseph Pilates developed the form of exercise known today as simply Pilates. In the 1920s, Joseph left his native Germany and came to New York City and began teaching his exercise style in dance studios.

    Today, Pilates has gained acceptance both as an exercise style for fitness and as a system for physical rehabilitation. Because of its benefits, Pilates is practiced in hospitals, wellness centers, gyms and specialized Pilates studios. It is used by athletes, dancers and anyone looking to increase endurance and improve flexibility, balance and muscle tone.

    The basic principle of Pilates focuses on increasing what is called core strength. Core muscle groups include the abdominal, pelvic floor and back muscles. If these muscle groups are strong, then the body is balanced and strong. The Pilates method also encourages flexibility by building long, strong muscles without bulk.

    The Stott method is one of the most popular forms of Pilates. This technique combines traditional Pilates exercises with movements updated to conform with modern knowledge about the biomechanics of the human body. By stabilizing muscles in the pelvis and shoulders, and keeping the spine and pelvis in safe, neutral positions, knowledgeable Pilates instructors minimize the chance of injury during these exercises.

    Pilates exercises have been shown to help reduce back pain. Researchers report that "Pilates method can be useful for patients with chronic low back pain and deconditioning" (J Manipulative Physiol Ther 2002 May; 25/4:E3).

    According to Ken Endelman, the founder of Balanced Body, maker of Pilates equipment, "Pilates is a full-body exercise. It focuses on flexibility and control, not adding bulk; bulk defeats flexibility. This flexibility is particularly important as we age. Staying flexible is key, and Pilates is good at those types of things."

    A Pilates routine can be structured to fit your specific physical needs or goals. Instructors use specially designed equipment along with mat work to improve fitness. The human body was designed to move. Again and again, research shows that exercise maintains health, vitality, longevity, weight and quality of life. If you match your exercise with your physical needs and goals, and your personality, you are more likely to stay with that program whether it is aerobics, walking, Pilates or yoga. For real benefits, physical fitness has to be a lifetime endeavor.



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    The Joints Are Jumping
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    Date: June 11, 2005 04:56 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: The Joints Are Jumping

    The Joints Are Jumping by Rachel Alexander Energy Times, October 8, 2003

    It usually starts with a twinge in your back or an ache in your knees: Knee stiffness, back pain and joint inflammation can signal the beginning of arthritis.

    According to the US Food and Drug Administration, arthritis affects over 42 million Americans-that's 1 in every 3 adults-and costs the economy nearly $65 billion annually. But as common as arthritis is, it doesn't have to extract a high cost from your joints.

    Who's At Risk?

    Arthritis literally means an "inflammation of the joints" and can affect anyone-from small children to 80-year-olds. Some groups are more prone to certain types of arthritis; for instance, those over 40 are at greater risk for developing osteoarthritis, a degenerative condition of the joints.

    According to Johns Hopkins Medical Institute, more than 50% of all individuals over the age of 40 have x-ray signs of osteoarthritis in weight-bearing joints (such as those in the knees and hips), and nearly half of those over 65 have measurable symptoms of arthritis. Osteoarthritis is often caused by overuse, age, excess weight or genetics, or by a combination of these factors.

    Rheumatoid arthritis, on the other hand, is a disease of the immune system that affects the joints, which can make it harder to diagnose because early symptoms-fatigue, weakness, loss of appetite and low-grade fever-can mimic other chronic conditions.

    Stiffness and pain may or may not accompany the initial symptoms of rheumatoid arthritis. However, joints eventually become inflamed and swollen. Although less common that osteoarthritis, rheumatoid arthritis affects more than 2 million Americans.

    Covering Up the Signs

    Treating arthritis can involve the use of both conventional and non-conventional therapies.

    "In osteoarthritis specifically, conventional medicine has just been focused on covering up the symptoms," says Jason Theodosakis, MD, author of The Arthritis Cure (St. Martin's Press). "In the history of medicine, this approach has been considered primitive."

    But Dr. Theodosakis points out that treatment often depends on the type of arthritis involved: "Rheumatoid arthritis patients should be taking prescription drugs that are known to prevent the disease from progressing. [Use] alternative medicine as an adjunct..."

    Conventional therapies often involve the use of non-steroidal anti-inflammatory (NSAID) medicines, such as ibuprofen and naproxen. The chief drawback of NSAIDs is the toll these treatments extort from the gastrointestinal system.

    In fact, a 2002 study conducted by researchers at the University of South Florida, Tampa, found that more than 15% of patients developed digestive problems after a five-week course of ibuprofen. In addition, ibuprofen may increase blood pressure.

    Newer prescription NSAIDs called COX-2 inhibitors, which work by suppressing the body's inflammatory response, also carry risks of side effects ranging from diarrhea and fluid retention to liver damage and kidney problems. In addition, people with asthma or chronic allergies (including to aspirin) should not take these medicines.

    Corticosteroids-another treatment option that has been used to lessen inflammation-can cause side effects such as increased appetite, mood changes and even immune system breakdown.

    Natural Answers

    A growing body of evidence shows that nutrients such as glucosamine and MSM, coupled with lifestyle changes, can help decrease or eliminate some of the aches and pains of arthritis. Glucosamine is a natural chemical that helps build joints. When the cartilage in joints deteriorates due to age or other factors, studies indicate that glucosamine provides the necessary building blocks for rebuilding and repairing this tissue.

    In one investigation (Archives of Internal Medicine 2002; 162:2113-23), scientists discovered that glucosamine slowed the progression of osteoarthritis and improved symptoms for over 200 patients. Another study, conducted by researchers in the Netherlands, demonstrated that a combination of glucosamine and chondroitin holds promise for conditions such as spinal disc degeneration.

    To date, several studies have confirmed glucosamine's ability to help the symptoms of arthritis, and the National Institutes of Health is currently supporting research to further study the benefits of glucosamine.

    Other Joint Aids

    MSM is often an adjunct therapy as it does not work directly on joints, but provides the raw materials, in this case sulfur, to help rebuild cartilage in the joint matrix. Studies indicate that sulfur has a protective effect and may interact with magnesium, an essential bone nutrient.

    Traditionally, the herb horsetail (Equisetum arvense) has been used to supply silica, a mineral component of nails, bones and joints. Its support of these structures can help in the fight against arthritis.

    As the body ages, it may lose much of its silica reserves. Resupplying much of this mineral may help support joints. In addition, experts believe, silica can help the body use calcium more effectively and support bone health.

    Since rheumatoid arthritis is a systemic affliction, you should work with a trained health professional in treating it. Complementary care practitioners often use antioxidant nutrients, such as vitamins C and E, to reduce free radical damage, along with pantothenic acid (vitamin B5) to lessen morning stiffness.

    A Joint Project

    According to Dr. Theodosakis, exercise is the key to dealing with arthritis: "[Start with] an individualized exercise program that strengthens the joints without causing more damage...and an eating program to control your weight if you are currently overweight." To limit the effects of arthritis, you should quit smoking, since smoking generates free radicals that can harm the tissues which make up joints. In addition, a strict vegan diet may help alleviate some of the pains of rheumatoid arthritis.

    Dr. Theodosakis also recommends looking for hidden causes of symptoms, such as food allergies, that may contribute to arthritis.

    Heat helps ease arthritis pain and encourages both blood flow and tissue repair. A plain, old-fashioned hot water bottle works quite well. Or you can use one of the newer heat-generating wraps, which are thin enough to be worn under clothing and don't have to be constantly reheated.

    You can't always avoid arthritis, especially as you get older. But you don't have to let it get the better of you.



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    Stevia, Xylitol Sugar alternatives ...
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    Date: June 09, 2005 06:15 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Stevia, Xylitol Sugar alternatives ...

    Xylitol

    Stevia

    Sugar Solution by Kristin Daniels Energy Times, January 4, 2002

    Sugar Solution by Kristin Daniels

    Low blood sugar-a blood sugar recession-can make the good times recede. While you can't live without blood sugar, too much or too little wreaks havoc on your body and mind. And when blood sugar dips low enough to cause hypoglycemia you may feel like your emotions have been shredded. Knowing how the body regulates blood sugar allows you a measure of control in keeping blood sugar in the proper groove, and makes life a little sweeter. Hypoglycemia occurs when you feel dragged out because of low blood sugar. Ironically, this low blood sugar syndrome may be caused by an overabundance of sugar in your meals and snacks. Those who point to hypoglycemia as a widespread problem claim that up to two of three women in America suffer from hypoglycemia. That would make it an epidemic of monstrous proportions. In a survey of 1000 folks complaining of hypoglycemia, published in the Hypoglycemia Support Foundation's winter 2000 edition, researchers found that low blood sugar sufferers complained of hypoglycemic discomforts in several main categories: 94% of the people in the study reported nervousness, 89% mentioned irritability, exhaustion affected 87%, depression struck 86% and drowsiness hit 73%. Other miseries included fatigue, cold sweats, tinnitus (ringing of the ears), rapid heart rate, blurry or double vision, confusion, sudden hunger, convulsions, sweating, sleeping problems, paleness, muscle pain, memory loss, crying jags, fainting and dizziness.

    Body of Evidence
    Hypoglycemia may result from munching endless sweets and never exercising (physical activity improves your body's handling of sugar). Many sufferers of hypoglycemia may view it as a disease, but the experts pigeonhole it, technically, as a condition or syndrome. R. Paul St. Amand, MD, Professor of Endocrinology at UCLA, points out that "in certain people, the body is unable to process carbohydrates without adverse consequences. Hypoglycemia, or low blood sugar, is the name often used to denote a whole disease. But more accurately it is only one of a cluster of symptoms that together make up a syndrome." According to herbalist Cynthia Hartson, ND, at Better Health Chiropractic and Natural Family Health Care in Mission Viejo, California, when you eat too many processed foods you set yourself up for a big fall in blood sugar. "...As with many conditions out there, you don't catch diseases, this one or any; you create an environment in your body that allows these symptoms (and conditions) to occur." Your body breaks down carbohydrates, including those in vegetables, fruits, breads and grains, into simpler sugars. As these carbohydrates pour into the blood in the form of glucose, cells in the pancreas secrete the hormone-like substance insulin. Insulin is supposed to persuade cells to take up this in-flow of glucose and use it as fuel. But if, during this process, blood sugar drops too low, the pancreas releases glucagon, which stimulates the release of glucose into the blood to bring blood sugar levels back up. Overindulging in sweets and processed foods may upset this blood sugar balancing act. Americans consume about 120 pounds of sugar per person annually, a voluminous avalanche compared to preindustrial times when we only took in about seven pounds a year. When you eat your way through this much sugar, Dr. St. Amand claims, your body's "...excess amounts of carbohydrates (generate) an overproduction of insulin. As your blood sugar drops, your brain tunes out. Because a massive amount of carbohydrates drives your insulin and glucagon down, the fats (stored as carbohydrates) in your body can't be released (for energy) and you crave more carbohydrates." As you continue to consume large amounts of carbohydrates, the pancreas secretes greater amounts of insulin to properly transport the excesses of circulating blood sugar. Eventually, every time you eat sugar, your pancreas may release excessive insulin, which drives and keeps your blood sugar low enough to make you feel like lying down in a corner and telling the world to go away. And there's more bad physiological news: Your adrenal glands respond to this stress by producing adrenaline and dumping it into the bloodstream in overabundance, causing anxiety, trembling and panic attacks: frequent signs of a hypoglycemic reaction. Adrenaline is supposed to stimulate the liver to release glycogen (stored sugar) to get your blood sugar back to a functioning level. But once again, as your sugar cycle degenerates, the pancreas increasingly produces more insulin to drive down your blood sugar level. Your blood sugar may drop and stay down.

    Numbers Game
    Many conventional doctors dismiss hypoglycemia as an illusion. But Dr. St. Amand states that doctors are "hung up on numbers." The glucose tolerance test, typically used to diagnose hypoglycemia, is based on numbers and the numbers often don't add up. Signs of hypoglycemia typically show up to two to three hours after a meal or snack containing lots of processed foods, when there is a rapid release of sugar into the small intestine, followed by rapid glucose absorption into the bloodstream and the consequent production of a large amount of insulin. These reactions occur so rapidly and unpredictably that catching them in a glucose tolerance test is often impossible. (Of course, see your health practitioner if you suffer persistent health problems that may be caused by a serious underlying condition or disease.)

    Diary of a Maddening Condition
    Keeping a food diary can help you discover what foods set off your hypoglycemia. Be honest, and record everything: your food, drinks, even breath mints! Note the time you eat, the time you sleep, the exercise you do, and your moods to see what triggers low blood sugar. Once you identify your triggers, remove them. When recommending ways to dodge hypoglycemia, Dr. St. Amand says, "It is not what you add but what you remove" that's most important. Items that often cause problems include:

  • * Sugar (obviously) of all kinds: table sugar, corn syrup, honey, sucrose, glucose, dextrose or maltose.
  • * Starches such as potatoes, rice, pasta and processed white breads.
  • * Fruit juices.
  • * Caffeine (coffee, tea, chocolate and soft drinks), which intensifies the action of insulin. The National Hypoglycemia Association says that foods which many hypoglycemia sufferers find to be helpful are those high in soluble dietary fiber and complex carbohydrates: whole grains, legumes and vegetables, which may be absorbed more gradually than processed items. Slower carbohydrate absorption may help prevent the major swings in blood sugar levels that foments hypoglycemia. Eating smaller meals and snacking often may ease blood sugar fluctuations. Incorporate fats into your snacks to decrease the flow of carbohydrates into your bloodstream and decrease carbohydrate cravings. Whole-wheat crackers with natural peanut butter, vegetables dipped in organic olive oil, packaged nuts and seeds, rice cakes, and soy cheese may slow sugar absorption. Your food diary should also record your activity level, the amount of water you drink, and indicate the times you feel stressed. While your diary may show that the stresses and lifestyle items that most frequently trigger your hypoglycemia are different than those that cause problems in others, you will probably discover that exercise significantly helps to dispel low blood sugar discomforts. Exercise tones your muscles, improves circulation and aids in digestion. It increases circulation and helps your muscles metabolize sugars more effectively.

    Review Time
    Ask your relatives to find others in your family who suffer diabetes, hyperinsulism or hypoglycemia. Roberta Ruggiero, president of the Hypoglycemia Support Foundation, Inc., and author of the book The Dos and Don'ts of Low Blood Sugar (Lifetime), notes that genetics plays a large role in reactive hypoglycemia. "In a survey of confirmed hypoglycemics," she states, "it was found that approximately 64 percent of them had one or more family members who had been diagnosed with diabetes." If you know someone in your family suffers this kind of problem, you can find it helpful to see what works for them to relieve the discomforts of low blood sugar. And you can share with them what works for you. Together, you can slip the shackles of hypoglycemia and sweeten your days.

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    Skin Eternal - Replenish Your Skin
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    Date: June 06, 2005 08:45 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Skin Eternal - Replenish Your Skin

    Skin Eternal

    Source Naturals is proud to introduce our new SKIN ETERNAL Cosmetic Line. Our advanced skin care products recharge and revitalize your skin. Each product features scientifically advanced nutraceuticals: nutrients and botanicals with an inborn affinity for skin. You can nourish your skin with Source Naturals’ richly emollient SKIN ETERNAL CREAM smoothed under your eyes or on your neck. Or use our light, aqueous SKIN ETERNAL SERUM. Both products gently addresses imbalances and infuse skin with visible radiance. For a luxuriant, moisturizing bath, simply add SKIN ETERNAL BATH OIL under warm running water. Whatever your individual preference, Source Naturals has a SKIN ETERNAL product that will leave your skin looking refreshed and energized.

    Now available from Source Naturals®: a variety of elegant cosmetics to moisturize, smooth and tone your skin.

    Your skin is a reflection of your health and well-being. To attain skin that looks truly alive, energized and refreshed, we believe a holistic approach is necessary. This includes nourishing your body with fresh, organic foods, exercising every day to motivate your mind and spirit, and eliminating unhealthy lifestyle choices. As part of this holistic approach, the Skin Eternal™ cosmetic line feeds your skin cells with scientifically advanced nutraceuticals: nutrients and botanicals with an inborn affinity for skin.

    SKIN ETERNAL™ CREAM

    Apply this rich and luxurious blend under and around your eyes or massage it with upward strokes onto your neck—your skin will immediately feel the difference! SKIN ETERNAL CREAM features nutrients, natural oils and plant extracts. Included are alpha lipoic acid, biotin, CoQ10, DMAE, jojoba oil, MSM, squalane, tocotrienols, and vitamin C-ester, as well as extracts of grape seed, ginkgo, ginseng, green tea, sage, marigold, and grapefruit seed.

    SKIN ETERNAL™ SERUM

    SKIN ETERNAL SERUM is an aqueous moisturizing serum that contains a rich blend of nutrients and plant extracts. It is easily absorbed, and immediately makes skin feel softer and replenished. SKIN ETERNAL SERUM is lightly scented with pure lavender and lemon oils, and contains nutrients and herbs unavailable in other topical preparations. These include aloe vera, alpha lipoic acid, biotin, CoQ10, DMAE, MSM, vitamins A, C-ester, D-3 and E, and chamomile. Source Naturals also offers SKIN ETERNAL DMAE SERUM.

    SKIN ETERNAL™ BATH OIL

    OUR NEW SKIN ETERNAL BATH OIL adds to your skin’s hydrolipic film, lightly coating your skin with nutrients. It holds moisture inside and protects your skin. Its unique formula is rich in alpha lipoic acid, DMAE, essential fatty acids, vitamins C-ester and E, plus other nutrients and plant extracts. SKIN ETERNAL BATH OIL is lightly scented with pure lavender and lemon oils. And it is hypoallergenic and contains no alpha hydroxy acids—so it can be used even on delicate, sensitive skin.

    Lifestyle Tips for Healthy Skin: A Strategy for WellnessSM

    Eat a Healthy Diet Low-nutrient foods, such as sugar and refined carbohydrates, will not provide the vitamins and minerals your skin needs. Choose unprocessed organic foods, high in antioxidants such as beta carotene (carrots, apricots, and squash), vitamin C (oranges and peppers), vitamin E (cold-pressed oils, nuts and seeds), selenium (tuna, garlic, onions and broccoli) and zinc (whole grains, most seafood, and onions). Essential fatty acids, such as those in oily fish, flaxseed and olive oil, are important for skin repair. Eat high-fiber fruits, vegetables, whole grain bread and cereals, and brown rice. Restrict excess sodium intake.

    Take Supplements

    Key nutraceuticals can help radiate beauty from within, by supporting body systems involved with healthy, radiant skin. These nutraceuticals include alpha lipoic acid, DMAE, ascorbyl palmitate (vitamin C-ester), vitamin E and grapeseed extract. Source Naturals offers you SKIN ETERNAL™ tablets with these five ingredients, to protect against free radical damage and provide cofactors for healthy skin tissue. Source Naturals SKIN ETERNAL PLUS is a Bio-Aligned Formula™, which includes these key nutraceuticals plus 30 more! It is designed to support multiple body systems: antioxidant defense, connective tissue, cell membranes, cell renewal, blood and liver cleansing, muscle and nerve function, and stress response. It is also useful to supplement with essential fatty acids, such as omega-3 and omega-6 fatty acids, flaxseed and primrose oil.

    Drink Water

    Our bodies are made up of 50-70% water, so it’s important to drink at least 1.5 liters daily. Water flushes out wastes, and acts as an internal moisturizer, keeping skin hydrated and supple. Spring water is beneficial since it contains trace minerals vital to healthy skin.

    Protect Your Skin from the Sun

    Avoid direct sun from 10 am to 4 pm, when ultraviolet radiation is strongest. Use sunscreen even during winter and on cloudy days. Wear a broad-brimmed hat and sunglasses with full UV protection.

    Get Plenty of Sleep

    Research has shown that skin regenerates itself between 1-3 am; lack of sleep during those hours can cause skin to look dull or puffy. Taking a melatonin supplement can be helpful in supporting your body’s normal sleep cycle.

    Exercise Regularly

    Exercise increases circulation, which delivers nutrients necessary for a clear, glowing complexion. It also burns off fat, helps eliminate toxins, and is a great stress reliever. Exercise three to five times a week until you are perspiring freely and breathing deeply.

    Avoid Excessive Alcohol and Coffee

    Alcohol weakens the immune system and depletes nutrients. It causes dehydration, depriving skin of moisture, and overtaxes the liver, which helps keep impurities from reaching other organs. Alcohol consumption can lead to broken or distended capillaries, especially over the nose and cheeks. Caffeine-rich beverages like coffee promote dehydration, leaving skin flaky and dry. Substitute herbal or green tea for coffee.

    Stop Smoking

    Smoking slows healing and regeneration, causes carbon monoxide to increase in blood, and induces free radical formation. Nicotine constricts blood vessels and reduces blood flow to skin. The benzopyrene in cigarette smoke inhibits absorption of vitamin C, which is important for collagen synthesis.



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    SAMe - Supports Joint Comfort, Function and Mobility ...
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    Date: June 06, 2005 08:30 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: SAMe - Supports Joint Comfort, Function and Mobility ...

    SAMe (S-adenosyl-L-methionine)

    You’ve read about it in the media. Europeans have experienced its health benefits for two decades. Now consumers in the United States have access to a nutrient with groundbreaking potential. SAMe, a natural compound formed in our bodies from the amino acid methionine, is stirring excitement due to its wide-ranging health effects. SAMe plays a critical role in cartilage formation. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. SAMe has also been found to support a positive outlook. It affects the synthesis and activation of proteins such as mood-boosting neurotransmitters.

    Cutting-Edge Nutrition

    Technological advances have made possible the production of stable, bioavailable forms of a natural nutrient with broad-range potential. Source Naturals now offers you the fruits of that technology.

    A Multipurpose Nutrient

    SAMe, or S-adenosyl L-methionine, is formed when our bodies combine the amino acid L-methionine with ATP, the primary energy-carrying molecule in our cells. SAMe is a multipurpose nutrient, which is present in every living cell. Because SAMe is involved in so many vital processes, it is important that our bodies produce sufficient SAMe. However, SAMe levels tend to decline with age, and also can be affected by dietary imbalances. To produce adequate amounts, we need to consume not only methionine-containing protein foods, but also foods rich in vitamins B-6, B-12 and folic acid, which are needed to ensure the synthesis of SAMe. SAMe also is a highly unstable molecule. A lot of scientific research was needed to make it available as a supplement. Source Naturals has studied the research and offers this vital nutrient in a form your body can use.

    Methylation is the Key

    SAMe is known as a “methyl donor.” This means that it works by giving up a piece of itself (a methyl group consisting of one carbon and three hydrogen atoms) to other molecules. This methylation process affects the synthesis, activation and metabolism of various hormones, neurotransmitters, phospholipids, nucleic acids, proteins and other biological molecules. Methylation plays a part in many critical functions, including the maintenance of cell membranes, the removal of toxic substances from the body and the production of mood-boosting neurotransmitters such as dopamine and serotonin.

    Effective Joint Support

    SAMe has been used in Europe for two decades for joint support. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. SAMe is important in a process called transsulfuration. The breakdown of SAMe generates sulfate groups that help maintain joint cartilage. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage.

    Promotes Mental Well-Being

    Studies also show that SAMe helps support a positive outlook. Although the mechanism by which SAMe promotes mental well-being is not known, we do know it is able to cross the blood-brain barrier, where it affects the production of mood-boosting neurotransmitters.

    Clinically Researched Potency

    Source Naturals SAME is offered in the clinically researched potency of 400 mg per suggested daily use (two tablets). The tablets are enteric coated and blister packed to prevent breakdown and inactivation of ingredients. Source Naturals SAME is available in 20-tablet boxes.

    References:
    Berger, R. et al. 1987. “A New Medical Approach....” The American Journal of Medicine; 83(5A): 84-88. Carney, MWP et al. 1987. “S-adenosylmethionine....” The American Journal of Medicine; 83(5A): 104-106. Konig, B. 1987. “A long-term (two years) clinical trial of oral S-adenosylmethionine....” The American Journal of Medicine; 83(5A): 89-94. Stramentinoli, G. 1987. “Pharmacological aspects of S-adenosylmethionine.” The American Journal of Medicine; 83(5A):35-42



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    Mega H- Hydrogen (H-)The Fuel of Life
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    Date: June 03, 2005 05:00 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Mega H- Hydrogen (H-)The Fuel of Life

    Our universe is composed of millions of compounds, all derived from just 106 atoms. Of these elements, hydrogen is the first and most fundamental.

    Hydrogen is also the most abundant element, comprising 90% of all atoms in the cosmos. In our sun and stars, hydrogen nuclei fuse to produce helium, the second element. This generates the enormous energy that powers life on earth. And just as hydrogen fuels the sun, so, in the human body, it is the essential factor in the electrochemical process that produces ATP, the energy molecule. Virtually all the millions of biochemical processes that occur every second of our lives are powered by ATP. These facts are well established. But they are so basic that, until now, they have been overlooked in the world of nutritional science. It took the dedicated research of Dr. Patrick Flanagan to harness the power of active hydrogen for health and human development.

    Introducing a revolutionary breakthrough in the field of nutritional science: MEGA H-™ Active Hydrogen (H-), the Fuel of Life.

    The Creation of Mega H-

    For 30 years Dr. Patrick Flanagan’s life work has been to discover the health and longevity secrets of the Hunza people of the Himalayas. It is believed a much greater percentage of people there live past the age of 100, with far less of the diseases that ravage the West. The locals claimed that their secret was the cloudy, mineral-rich water that rushes down from the Himalayan glaciers. In studying the properties of this Hunza water, Dr. Flanagan found that silica crystals dissolved in the water were able to hold negatively charged hydrogen ions (H-). These compounds are technically called silica hydrides. This makes Hunza water a power source, filled with the same active H- that powers the human body.

    Typically hydrogen has one positively charged proton in the nucleus and one negatively charged electron orbiting the nucleus. The two opposite charges balance each other, resulting in no charge. Active hydrogen, on the other hand, contains two electrons orbiting the nucleus, creating a negative charge. It is this active hydrogen in its charged form that the body needs to carry out its crucial functions. Dr. Flanagan has recreated this silica hydride compound as MEGA H-™.

    Cellular Energy: ATP, Hydrogen and Mega H-™

    ATP, adenosine triphosphate, is composed of three phosphates. The breaking of the bond between the second and third phosphates releases the energy to power virtually all cellular processes. Amazingly, we all generate enough metabolic energy to produce our own body weight in ATP every day just to function! Every second, each of our approximately 50 trillion cells consumes and regenerates 10 million molecules of ATP.

    This massive energy generation (ATP production) is the fundamental core function of every human cell. Without it, basic activities such as cellular repair, and protein, enzyme, hormone and neurotransmitter synthesis would not occur. DNA repair and cell reproduction would cease. Thoughts, feelings, communication, and our ability to experience the world through our senses and change it through our actions would stop. The negative implication of poor energy generation for our health and vitality levels is significant. Many factors such as aging, poor nutrition and pollution can impede this critical energy generation. Negatively charged electrons from hydrogen are the source of the energy needed to generate this staggering amount of ATP. This energy production takes place in the mitochondria of the cells at the final stage of the Krebs Cycle, called the electron transport chain. Typically, the hydrogen comes from the breakdown of carbohydrates from food, which yields hydrogen as well as carbon and oxygen. But MEGA H-™ is an alternative, electron- rich source of hydrogen to power energy generation. In fact, MEGA H-™ has been shown to double the production of ATP and NADH, according to in vitro studies. (NADH is the coenzyme form of vitamin B-3, niacin, that carries hydrogen to the production site of ATP.) If this alone was all that MEGA H-™ could accomplish, it would be the most significant nutritional compound yet discovered. But its properties go far beyond energy generation. It is the body’s most efficient and effective antioxidant. MEGA H-™ also increases cellular hydration and the uptake of nutrients into each cell by lowering the surface tension of water (making water “wetter”). And it can improve athletic performance by lowering lactic acid levels after strenuous workouts.

    Aging and Antioxidant Defense

    Energy Decline: As we age, there is a decrease in our bodies’ ability to generate cellular energy—and oxidative damage may be a primary factor. Many scientists now accept the theory of aging first proposed by noted scientist Denham Harman, M.D., Ph.D., who argued that “aging changes are induced by free radical reactions, largely initiated by the mitochondria … the rate of damage to the mitochondria determines our life span.” Why is this? While oxygen is necessary for human life, the very act of breathing generates free radicals. Our mitochondria— tiny energy production plants—are the chief source of oxidants produced in our bodies. It is believed these oxidants damage the mitochondria in which they are produced, including the inner mitochondrial membrane, which is the site of ATP production. This would seriously impair the ability of mitochondria to meet cellular energy demands. The result: signs of normal aging such as impaired memory, hearing, vision and stamina.

    DNA Damage: Oxidants also can damage the cell’s DNA. Hydroxyl radicals cause DNA strands to break; if breaks occur in both strands of DNA, the cell cannot repair the damage and will die. Normally, the body has mechanisms to correct or remove damaged cells. However, as we age and cellular energy production declines, the ability to correct these errors is significantly reduced. Left unrepaired, DNA errors may be passed on when cells divide. Over time, these errors can silently accumulate, leading to cellular changes that go unnoticed until body system imbalances become evident.

    World’s Most Elemental Antioxidant

    MEGA H-™ may be the world’s most powerful antioxidant. It is possible to measure the Oxidation Reduction Potential (ORP) of any compound. This rating, which measures the number of electrons present in relation to protons, ranges from (plus) +1,200 to (minus) -800 millivolts; the stronger an antioxidant is, the closer its ORP would be to -800. The more positive the ORP reading, the fewer the number of available electrons from active hydrogen. In chemistry, active hydrogen is defined as hydrogen with an extra electron, also known as the hydrogen anion, negative hydrogen or H-. The strongest natural antioxidants up until now, such as grape seed and green tea, have ORP’s of -100. But Mega H-™ has an ORP of -778 millivolts, as compared to distilled water, making it the most potent natural antioxidant available today. What’s more, MEGA H-™ is in a class by itself, compared to other antioxidants, due to its electrochemical structure. Free radi-cals—unstable molecules that are missing one or more electrons—damage cells by taking electrons from healthy molecules to balance themselves. When other antioxidants donate electrons to quench free radicals, they in turn become reactive free radicals and require electrons from other antioxidants to become stable. The new antioxidant also requires an electron to return to stability. This process continues, resulting in an inefficient and energy-consuming free radical cascade. But MEGA H-™’s negatively charged hydrogen molecule possesses two electrons instead of the typical one. This extra electron can be donated without generating the inefficient free radical cascade. Dr. Flanagan’s profound contribution was his discovery of a method for stabilizing and delivering negatively charged hydrogen (H-). Unlike taking other antioxidants, supplementing with MEGA H-™ provides a net gain of free radical-quenching electrons into the system.

    Additional Health Benefits

    MEGA H-™ has been the subject of additional positive research: Increases Cellular Hydration: Water is important to cells, interstitial fluids (surrounding joints, muscles and organs), and the matrix of blood. As the body’s primary fluid, water serves as a solvent for nutrients. Since water is used to carry nutrients into the cell, it is theorized that increased cellular hydration also increases the bioavailability of nutrients. Water also eliminates toxins and waste products from the body. From energy production to joint lubrication, all our systems depend on water. It has been theorized that aging results in cell dehydration. A study done by Gary Osborn and H. Salinas, M.D. of the Texas Institute of Functional Medicines suggests that silica hydride supplements like MEGA H-™ increase intracellular, extracellular and total body water levels. It is theorized they work by decreasing water’s surface tension, which allows water and nutrients to more easily enter cells and become available for use by the body. Assists In Exercise Recovery: During strenuous exercise, the oxygen supply to muscle cells is insufficient to meet energy demands. Muscle cells then turn to anaerobic respiration to continue to generate energy. This creates lactic acid, which diffuses into the blood, causing muscle fatigue, soreness and loss of endurance. A placebo-controlled study on six healthy males showed that blood lactate levels significantly decreased after exercise when silica hydride supplements were taken for one week before an exercise trial.

    The Scientist Behind Mega H-™

    This revolutionary approach to nutrition and health is the brain child of Dr. Patrick Flanagan. Dr. Flanagan was a child prodigy with an intense interest in electronics, biochemistry and physics. At the age of 12, he invented a guided missile and atom bomb detector. This technology was subsequently adopted for use by the U.S. government. At 14 he developed the Neurophone®. This device transmits acoustic information to the brain by means of radio waves into the skin, bypassing the eighth cranial nerve, and may allow some deaf people to hear. By the age of 18, he was named one of the Top Ten most promising young scientists in America by Life Magazine. Dr. Flanagan’s work with MEGA H-™ has its roots in his collaboration with Dr. Henri Coanda, a respected scientist who died in 1972. Dr. Coanda passed along his investigation into Hunza water to Dr. Flanagan. MEGA H- is the culmination of decades of research to bring the energizing and anti-aging benefits of active hydrogen (H-) to the world.

    Mega H-™

    Hydrogen (H-)The Fuel of Life

  • • The first active hydrogen supplement (H-), a rich source of electrons.
  • • Electrons from H- are a source of energy to generate the body’s staggering amounts of ATP (energy molecule).
  • • MEGA H-™ doubles cellular ATP and NADH in vitro.
  • • Theorized to be the most potent antioxidant in vitro.
  • • May decrease lactic acid levels after exercise.
  • • May increase cellular hydration.

    MEGA H-™ is the first supplement available in the natural foods industry to provide a large reservoir of freely available electrons to power the body’s diverse energy functions.



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    HEART RESPONSE - Comprehensive Support for a Healthy Heart!
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    Date: June 02, 2005 11:51 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: HEART RESPONSE - Comprehensive Support for a Healthy Heart!

    Heart Response 60ct

    Today’s modern lifestyle, filled with stress, pollution, overprocessed and fatty foods, and lack of exercise, places great strains on the cardiovascular system. Source Naturals HEART RESPONSE is a broad-range formula that supports cardiovascular health, especially heart muscle contraction, healthy circulation and the generation of cellular energy.

    HEART RESPONSE features clinical potencies of the renowned heart botanical, hawthorn, and significant amounts of the energy nutrients, coenzyme Q10 and carnitine, along with additional nutrients and herbs. Each daily use supplies 600 mg of hawthorn, the same amount used in recent research.

    Supports Heart Health

    HEART RESPONSE was formulated to include key nutrients and herbs known to support the cardiovascular system.

    Hawthorn: Hawthorn, a rich source of flavonoids and procyanidins, has been used traditionally all over the world as a strengthening circulatory and heart tonic.

    Modern research has documented that hawthorn increases coronary blood flow and strengthens the contraction of heart muscle. Hawthorn is also an antioxidant, which scavenges and neutralizes destructive free radicals. It is only when cholesterol is oxidized that it impacts the integrity of arteries.

    Coenzyme Q10: HEART RESPONSE supplies 60 mg daily of CoQ10, a key enzyme in the Electron Transport Chain, the pathway that generates 90% of the ATP “energy currency” needed by the body. Heart muscle requires huge amounts of energy to perform efficiently—it beats more than 100,000 times each day, pumping more than 1,000 gallons of blood through the body. The heart utilizes ATP as an energy source for muscular contraction. CoQ10 also is a fat-soluble antioxidant.

    L-Carnitine: Carnitine is an amino acid-derived substance that supports heart muscle metabolism. Carnitine is needed to carry long chain fatty acids into the cell mitochondria, where they undergo oxidation to generate energy. The heart utilizes fatty acids as a preferred energy source for its metabolism.

    HEART RESPONSE delivers 300 mg per day of carntine. Taurine and Magnesium: Magnesium and taurine work closely together in the body to help maintain the normal electrical rhythm of the heart. Taurine comprises more than 50% of the free amino acid pool in our hearts, and has many electrophysiological effects on cardiac muscle cells. Alterations in magnesium levels can have profound effects on the heart. Magnesium is involved in autonomic control of the heart through several mechanisms. Bromelain: Bromelain is an enzyme mixture prepared from pineapple stems. Pineapple has been used for its health benefits for more than 500 years.

    Grape Seed Extract: Grape seed is a source of procyanidins. These plant constituents are strong antioxidants that inhibit lipid peroxidation and scavenge free radicals. In vitro studies have demonstrated that procyanidins support the integrity of connective tissue. Garlic: The use of garlic for its health benefits predates written history. Garlic’s volatile oil includes sulfur-containing compounds such as allicin, which are considered to be important biological constituents.

    Selenium: Selenium is an essential trace mineral that is necessary for the activity of the important antioxidant glutathione. Antioxidants are crucial for protecting cholesterol from oxidation, which in turn helps to maintain healthy blood vessels. B-Vitamins: Preventing an undesirable buildup of homocysteine levels may help support the integrity of arteries. Vitamins B-6, B-12 and folic acid are critical to the regulation of homocysteine levels.

    You can count on Source Naturals’ expert formulators to bring you a product based on the most up-to-date nutritional research. HEART RESPONSE combines traditional botanicals and cutting-edge nutrients, scientifically formulated to deal with many aspects of cardiovascular health. It is available in bottles of 30, 60 and 90 tablets.

    References
    Heinicke, R.M. et al. 1972. Effect of bromelain (ananase) … Experientia. 28(7):844-5. Karpati, G. et al. 1975. The syndrome of carnitine deficiency. Neurology. 25:16-24. Schmidt, U. et al. 1994. Efficacy of the Hawthorn (Cratageus) preparation L1 132 … Phytomedicine. 1:17-24. Upton, R. ed. Hawthorn Leaf with Flower – Cratageus spp. Santa Cruz: American Herbal Pharmacopoeia, 1999.



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    GlucosaMend™ Tissue/Joint Repair Complex
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    Date: June 02, 2005 11:19 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: GlucosaMend™ Tissue/Joint Repair Complex

    GlucosaMend

    More than 40 million Americans experience joint discomfort. But exciting new research proves you can do something about it. Our health and well-being is inextricably linked to lifestyle choices: the right combination of exercise, weight training and supplementation can strengthen muscles and joint tissues to minimize stress and degradation. Targeted nutrition to the multiple body systems related to joint and connective tissue can help maintain flexibility and joint comfort. GLUCOSAMEND supports the musculoskeletal system with structural building blocks and tissue production cofactors, as well as aiding the body’s mechanisms for soothing relief and antioxidant defense.

    Bio-Aligned Formula™ GLUCOSAMEND is uniquely effective because it is a Bio-Aligned Formula. Source Naturals evaluates the underlying causes of system imbalances. Then we design formulas that provide targeted nutrition to bring your interrelated body systems back into balance.

    Musculoskeletal System—Structural Building Blocks

    Certain building blocks of joints and connective tissue can help maintain joint integrity and comfort. Glucosamine is a major constituent of glycosaminoglycans, which in turn form proteoglycans, molecules that hold and bind the water that lubricates joints, disperses stress and nourishes joint tissue. The amino acids proline and lysine are structural components of collagen and elastin, which give strength to connective tissue. GLUCOSAMEND contains glucosamine sulfate, N-acetyl glucosamine, proline and lysine.

    Musculoskeletal System—Tissue Production Cofactors

    Some micronutrients are necessary as cofactors in the production of connective tissue. For example, vitamin C and copper help form hydroxyproline and hydroxylysine, main constituents of collagen. A unique property of grape seed extract is its ability to form a bond between broken collagen fibers, helping to repair them and restore flexibility and strength to connective tissues and joints. GLUCOSAMEND provides vitamin C, zinc, manganese, copper, and grape seed extract to address these cofactors.

    Soothing Relief Mechanisms

    Some herbs and nutrients have the capacity to support the body’s natural mechanisms for increasing comfort. Boswellia, for example, is an herb with soothing properties, while vitamin B-6 helps to stabilize collagen and elastin. Additional herbs and nutrients, acting in conjunction with antioxidant protectors, support tissue comfort and health. GLUCOSAMEND contains Boswellia serrata, quercetin, copper, and vitamin B-6.

    Antioxidant Defense

    The health and integrity of joints and tissues—specifically of cell membranes— is supported by botanicals and nutrients that support the body’s natural antioxidant response. When tissues become damaged, the body mounts a repair process that ultimately generates free radicals. These free radicals can also break down healthy cells and tissues in the process, hence the need for antioxidants to neutralize and break the cycle. GLUCOSAMEND provides grape seed extract, vitamin C, zinc, selenium, copper, quercetin to neutralize free radicals.

    Lifestyle Tips for Healthy Joints: A Strategy for WellnessSM

    Healthy lifestyle habits should be part of your individual strategy for joint wellness. Source Naturals believes in a holistic approach to living. Not only can supplements bring balances to your individual body systems but certain lifestyle choices can also bio-align your health. Exercise Regularly: Regular physical activity helps lubricate cartilage, strengthens muscles around joints, and promotes weight control. An exercise program geared to joint health includes stretching, mild weight training, and low-impact aerobics. Watch Your Weight: Population-based studies, including the well-known Framingham study, have consistently shown a link between obesity and challenges to joint health. Excess weight causes pressure on joints, and can speed the rate at which cartilage wears down. Eat Healthy: To support healthy joints, increase your intake of omega-3 fatty acids from salmon, sardines, flax seeds or flax oil, avoid excess protein intake, and replace animal with plant proteins when possible. You should also eat lots of organically grown fruits and vegetables, limit saturated fat and eliminate hydrogenated oils. Rest and Relaxation: Regularly scheduled rest gives your body time to recover and rebuild, allowing you to make the most of your exercise program. It’s important to know when to slow down. Supplementation: Source Naturals offers a range of products that can supplement your strategy for joint wellness. These include the pineapple enzyme BROMELAIN; SAME, a natural compound formed from the amino acid methionine, which has been found to support joint comfort and mobility; and CHONDROITIN to promote water retention and elasticity in cartilage and inhibit enzymes that break down cartilage.

    Structural Building Blocks N-Acetyl Glucosamine, Glucosamine Sulfate, L-Lysine, L-Proline Tissue Production Cofactors Grape Seed, Copper, Manganese, Zinc, Vitamins A, B-6 and C, Niacinamide Soothing Relief Mechanisms Boswellia Serrata, Quercetin, Turmeric, Copper, Magnesium, Zinc, Vitamin C Antioxidant Defense Grape Seed, Quercetin, Manganese, Selenium, Zinc, Vitamins A, C and E

    References
    Bhavan’s, B. H. Selected Medicinal Plants of India (A Monograph of Identity, Safety, and Clinical Usage) Bombay: Chemexcil, 1992. Dore-Duffy, P., et al. (1990, Nov-Dec.). “Zinc profiles...” Clinical and Experimental Rheumatology 8.6: 541-46. Ellis, J. M. (1985, Winter). “Vitamin B6 deficiency and rheumatism.” Anabolism. Lakshmi, R., et al. (1991, Oct-Dec.). “Effect of riboflavin or pyridoxine deficiency on inflammatory response.” Indian Journal of Biochemistry and Biophysics 28.5-6: 481-84. Leibovitz, B., (1991). Nutrition Update 5.3: 5. Levine, M. (1986). “New concepts in the biology and biochemistry of ascorbic acid.” New England Journal of Medicine 314: 892-902. Pavelka, K, Gatterova, J., Olejarova, M, Machacek, S., Giacovelli, G., Rovati, L.C., (2002). “Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis: A 3-Year, Randomized, Placebo-Controlled, Double-Blind Study. Arch Intern Med, 2002 October 14; 162(18):2113-23. Roubenoff, R., et al. (1995, Jan.). “Abnormal vitamin B6 status...” Arthritis and Rheumatism 38.1: 105-9. Shampe, P., and R. Harvey. Lippincotts Illustrated Reviews: Biochemistry. Philadelphia: J. B. Lippincott Company, 1987. Tarp, U., et al. (1985). Scandanavian Journal of Rheumatology 14.2: 97-101. Volpi, N., (2002). “Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers,” 2002 Oct; 10(10):768.



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    Fibro Response - Feel your Vitality ...
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    Date: June 02, 2005 09:56 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Fibro Response - Feel your Vitality ...

    Fibro Response

    Millions of Americans, the majority of them women, are looking for a product to soothe muscles, relieve joints, support energy, and assist the liver’s natural detoxification process. Source Naturals FIBRO-RESPONSE is based on recent research into the physiological mechanisms involved in muscular metabolism. This research has given new hope to millions of people.

    Fibro-Response: A Bio-Aligned Formulation™ FIBRO-RESPONSE is the latest in a series of formulas we refer to as Bio- Aligned Formulations. We evaluate the underlying causes of system imbalances, then design products that support alignment and harmony in your body’s interdependent systems and functions. These formulas provide targeted nutrition to help create Body Systems in Harmony™.

    FIBRO-RESPONSE was designed to help bring harmony to the interdependent systems and functions that influence joint and muscle health. Our muscles need energy and oxygen to prevent them from becoming fatigued. FIBRO-RESPONSE soothes muscles and joints by supporting oxygen supply and energy production, provides powerful antioxidants for healthy joints and connective tissue, assists healthy liver function, and supports the nervous system and circulation. The ingredients were carefully selected to influence a range of body systems. Some were included for their combined effects with other ingredients; some play important roles in more than one body system.

    Muscles and Energy Production: Our muscle cells are powered by adenosine triphosphate (ATP), a compound popularly referred to as “the energy molecule.” ATP supplies energy for all the body’s myriad physiological processes. To provide this chemical energy, the body generates and uses an amazing two to three pounds of ATP every day! ATP production occurs through a series of complex chemical reactions, including the Krebs cycle and the electron transport chain—and these energy production systems in turn require sufficient nutrients. Malic acid, a natural fruit acid that is also produced in our cells, and the essential mineral magnesium, are critical components of the energy production cycle in muscle cells. FIBRO-RESPONSE supplies both in the amounts used in recent scientific research. Additional ingredients that support energy production include coenzyme Q10, a coenzyme in the energy- producing pathways; manganese, which activates many metabolic enzymes; and copper, an important component of energy-producing enzymes. Pantothenic acid, and alpha-lipoic acid help form coenzyme A, a primary starting material for ATP production (pantothenic acid also supports the adrenal glands). Vitamins B-1, B-2, niacin and B-6 are all required for energy production.

    Connective Tissue: Healthy connective tissue is essential for proper muscle function. MSM dietary sulfur supports the integrity of connective tissue and joints. MSM is included in FIBRO-RESPONSE in the amount used in recent joint health studies. Vitamins A and C, zinc, manganese, and copper all have important roles in supporting connective tissue. Liver Support: The liver is the largest and one of the most important body organs. Its vital functions include clearing the blood of toxins, and producing bile, which aids in fat digestion and carries waste products away from the liver. Liver detoxification is essential for muscle and joint comfort. Silymarin from milk thistle seeds is an important contributor to the support of healthy liver function. N-acetyl cysteine serves as a precursor to glutathione, a critical selenium-containing antioxidant produced in the liver, which binds to toxins to help remove them from the body. Alpha-lipoic acid and coenzyme Q10 play important roles in supporting liver health. This is partly because they are components of the body’s energy production process, and the liver demands a great deal of energy. FIBRORESPONSE also contains a classic Chinese herbal combination traditionally used to harmonize liver “chi” or “energy”: bupleurum, ginseng, pinellia, skullcap, ginger, cinnamon, and licorice. Their actions are complemented by the traditional Western herb dandelion.

    Antioxidant Support: Antioxidants protect tissues and joints from highly destructive molecules called free radicals. Alpha-lipoic acid, termed the “ideal antioxidant,” complements the antioxidant activity of beta carotene and coenzyme Q10. Nacetyl cysteine, best known for supporting the liver, is also highly valued as an antoxidant. Zinc, selenium and copper support our natural defenses. Together, they provide a full armory of powerful antioxidants for joints and connective tissue.

    Nervous System Support: Ginkgo biloba is renowned for promoting blood flow to the brain. This is crucial, since brain tissue is very metabolically active, accounting for 2% of our body weight, yet using 15% of our total energy supply. GABA is an inhibitory neurotransmitter that may regulate the nervous system and support clear focus. The herb skullcap, and vitamin B-6, add further support.

    Taking Back Your Life: A Strategy for WellnessSM

    Source Naturals’ expert formulators have created an experiential product that can make a difference in the way you feel. But supplementation is only part of the picture. Healthy lifestyle habits can redefine and empower your own strategy for wellness.

    Rest and Relaxation. Deep, uninterrupted sleep is essential for energy and a healthy nervous system. Sleep 8 to 10 hours nightly and aim to finish meals two hours before retiring.

    Exercise. Even if you feel exhausted and it hurts to move your muscles, you must keep moving. Start easy with nonimpact movement—yoga is an excellent beginning. Do some gentle stretches, followed by 5 to 10 minutes of blood-pumping activity (i.e. biking, stair-stepping, or dancing). Listen to your body: increase activity time only when it feels comfortable. Food and Nutrition. You’ve heard it before but now it’s time to pay attention: eat healthy. Avoid spicy, oily foods and choose light, mild alternatives. Go easy on sugar and incorporate whole grains into your diet. Enjoy steamed vegetables, alternate brown and white rice, and eat less red meat and more fish or soy. Reduce or eliminate milk products. Relax and take time to chew. And drink LOTS of water—it is essential for hydrating the body, flushing out wastes, and absorbing nutrients.

    Breathing. Many people hold their breath unintentionally, often as a result of stress or anxiety. This can become a habit, reducing blood oxygen, interrupting the pumping mechanism of the diaphragm that helps circulation, and causing muscles to become tense. Breathe deeply and feel your lungs expand and fill. Notice how different you feel.

    You have in your hand a powerful, comprehensive formula. Combined with a healthy lifestyle FIBRO-RESPONSE can help you make lasting changes that will empower you throughout life.

    FIBRO-RESPONSE is available in bottles of 45, 90 and 180 tablets.

    References Abraham, G. and J. Flechas. 1992. J. Nutritional Medicine (3): 49-59. American Medical Association, Encyclopedia of Medicine. New York: Random House, 1989. Garfinkel, L. and D. 1985. Magnesium (4): 60-72. Russell, I.J. et al. 1995. J. Rheumatology 22(5): 953-8.

    Targeted Nutrition Muscle Cell Metabolism Malic Acid, Magnesium, CoQ10, Vitamin B-1, (ATP Production) Vitamin B-2, Vitamin B-3, Vitamin B-6, Manganese, Pantothenic Acid, Copper, alpha-Lipoic Acid. Connective Tissue MSM, Vitamin A, Vitamin C, Zinc, Manganese, Copper Liver Silymarin from Milk Thistle, N-Acetyl Cysteine, Ginkgo Biloba, Dandelion Root, Chinese Liver Blend (Bupleurum, Skullcap, Panax Ginseng, Pinellia Root, Ginger, Cinnamon, Licorice Root) Antioxidant Support N-Acetyl Cysteine, alpha-Lipoic Acid, Beta Carotene, CoQ10, Zinc, Selenium, Copper, Nervous System GABA, Skullcap, Ginkgo Biloba, Vitamin B-6.



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    COENZYME Q10 - Transforming food into energy
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    Date: June 01, 2005 11:06 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: COENZYME Q10 - Transforming food into energy

    Coenzyme Q10

    It’s 3:30 p.m. and you feel irritable; you can’t seem to concentrate. You were so busy you skipped lunch. At last you bite into the sandwich that you were ready for 3 hours ago. By the time you have eaten half of it, energy is starting to flow through you. What happened? The answer to that question is both extremely complex and very simple. In essence, your body transformed the food into useable energy. CoQ10 is a crucial component of the primary energy generating cycle that takes place in each of the trillions of cells in our bodies. CoQ10 is essential for human life.

    To transform that lunchtime sandwich into useable energy your body essentially has to burn it - just the way a car burns gasoline to drive its engine. This energy generating process takes place in structures called mitochondria - tiny power plants which are within every cell. Inside these energy generating stations, fats, sugars, and amino acids are transformed into ATP, an energy-rich molecule sometimes called the “energy currency” of the body.

    Energy Generation Requires Nutrients

    The body requires many nutrients in order to perform the complex biochemical processes that convert food into ATP “energy currency.” Some of these nutrients such as the B-vitamins are familiar to us. However, there are many other substances which are essential to this process. Coenzyme Q10 is one of these.

    Functions of CoQ10

    Several complex metabolic pathways are required in order for the body to transform that lunchtime sandwich into energy that you can feel and use. First glycolysis and the Krebs’ cycle break down large molecules of protein, carbohydrate and fat into smaller components. CoQ10 is a key enzyme in the Electron Transport Chain - the final stage in this extraordinary design. This pathway generates 90% of the ATP needed by the body from the food we eat. ATP provides the “energy currency” for the following crucial metabolic functions: 1) synthesis of cellular components including cholesterol and proteins (formed primarily by the liver), 2) nerve conduction (in the brain and peripheral nerves), and 3) energy for muscular contraction (of the heart and skeletal muscles). The Heart: The heart muscle (myocardium) consumes a tremendous amount of energy. Your heart beats over 100,000 times and pumps 1,000 gallons of blood each day! CoQ10 is necessary for the generation of the energy required by the heart. Numerous scientific studies have demonstrated that supplementation with this nutrient may support normal heart function. Its presence is necessary for cardiac performance during exercise as exemplified by criteria including: blood flow, oxygen utilization, contractility and exercise tolerance. In addition, CoQ10 may play a role in the regulation of blood pressure. The Gums: Since the 1970’s scientists have been researching the effects of CoQ10 on the health of the oral tissues. Although the mechanism of action is not known, research has established that CoQ10 has a profound ability to preserve and maintain the health of the gums. Antioxidant Properties: CoQ10 plays an additional vital role in our metabolism as a protector of lipids in cell membranes. Laboratory studies have also shown that CoQ10 is more efficient than vitamin E, beta carotene or lycopene in safeguarding LDL cholesterol from oxidation by peroxides. This process is important for maintaining the health of our blood vessels.

    Energy Insurance

    CoQ10 is needed in body tissues where energy production is critical, such as the liver, brain and muscles. Therefore we include CoQ10 in significant potencies in many of our premium formulas, such as Life Force Multiple™, Élan Vitàl™, Heart Science™, Liver Guard™, MenoBalance™, Higher Mind™, MegaMind™ and Wellness Multiple™. We also offer a combination of CoQ10 and Lipoic Acid (30 mg each), CoQ10 Sublingual (30 mg and 60 mg), 30 mg CoQ10 Softgels with Bioperine® and 30 mg CoQ10 NutraSpray™. Our single CoQ10 products are CoQ10 in 15 mg, 30 mg, 75 mg, 100 mg, and Ultra Potency 125 mg caps.

    References
    1) Folkers et al., BCACQ, Elsevier, 1977
    2) Judy et al., BCACQ, Elsevier, 1984.
    3) Kamikawa, T. et al., American Journal of Cardiology, Vol. 56, August 1, 1985, p. 247-250.
    4) Nohara et al., Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, 1984.
    5) Packer, L., Oxidative Stress and Aging, Birkhauser Verlad, 1995.
    6) Stocker, et al., Proceedings of the National Academy of Sciences, Vol. 88, pp 1646-1650, March 1991.
    7) Tortora, G. Principles of Human Anatomy, 4th Ed., Harper & Row, New York, 1986, p. 301.
    8) Wilkinson and Arnold, Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, 1977.
    9) Yamagami et al., Biomedical and Clinical Aspects of Coenzyme Q, Elsevier, 1977.



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    Cholestrex - Lower Cholesterol with Source Naturals Supplements
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    Date: June 01, 2005 10:41 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Cholestrex - Lower Cholesterol with Source Naturals Supplements

    Cholestrex

    Our lives depend on an uninterrupted flow of blood throughout the 60,000 miles of arteries, veins, and capillaries that bring vital nourishment to our cells. Our bodies have complex chemical strategies to maintain and repair blood vessel walls. Cholesterol is an important part of the process. However, too much cholesterol in the bloodstream can have serious consequences for our well-being. By understanding how nutrition affects blood cholesterol, we can gain valuable control of our health. Source Naturals CHOLESTREX has been formulated to provide the nutritional support that we need to maintain healthy cholesterol levels.

    SINCE DOCTORS FIRST DISCOVERED that cholesterol was the primary ingredient in the sticky deposits that clogged their patients’ arteries, scientists have gained a thorough understanding of cholesterol’s role in our health. Essential to human and animal life, cholesterol is part of every cell in the body. Because cholesterol is so important, the liver synthesizes from 1 to 2 grams of it each day. In addition, we get about another 500 mg from the foods we eat. Problems occur when too much cholesterol gets into the bloodstream. Today, it’s estimated that over 50 million adults in the United States have cholesterol levels that are too high. The body’s processes to manage excess cholesterol depend upon a lifestyle that includes exercise, stress reduction and proper nutrition. Source Naturals Cholestrex is designed to deliver a comprehensive combination of nutrients known to support a healthy blood vessel system – and keep the life stream flowing.

    The nutrients in CHOLESTREX are known to support a healthy blood vessel system

    Cholesterol: What It Is Cholesterol is a solid waxy substance, technically classed as a “sterol.” Cholesterol enables our cell membranes to maintain their integrity. It is the basic raw material from which the body makes steroid hormones, which include the sex hormones. Cholesterol is the primary component of bile salts that the liver creates to help us assimilate fats, fat-soluble vitamins and essential fatty acids. The liver also uses bile to rid itself of stored toxins. Our skin contains large amounts of cholesterol, making it resistant to the absorption of water-soluble toxins. Even the brain is 7% cholesterol (dry weight).

    Blood vessel walls cover a surface area of half an acre and are under constant pressure

    Cholesterol in the Blood

    Because it’s not water-soluble, cholesterol must be attached to a carrier molecule in order to be transported in the bloodstream. The liver manufactures two types of carrier molecules for cholesterol, LDL and HDL. LDL (low density lipoprotein) molecules carry cholesterol from the liver out to cells of the body. One of its functions is to repair damaged cells, including those of the artery walls. LDL is primarily made up of saturated fats, (meat fats, butter, etc.). HDL (high density lipoprotein) molecules transport cholesterol and fatty acids from body tissues back to the liver for disposal. HDL helps remove excess fat and cholesterol from the bloodstream. HDL is composed of liquid fats (most vegetable oils). It’s crucial to have a proper balance between LDL and HDL cholesterol. High LDL – a sign that the body has too much fat – is a threat to the health of blood vessels, because excess LDL cholesterol may accumulate in damaged areas of vessel walls. These “fatty streaks” are the beginning stage of artery blockage.

    The oxidation of LDL cholestrol is at the heart of the problem

    Cholesterol and Artery Damage

    The walls of the blood vessels cover a surface area of half an acre and are under constant pressure. Of all the blood vessels in the body, the coronary arteries are under the greatest stress. Named for the Latin word for crown (corona), they sit directly on the heart muscle and must continually expand and contract with every heartbeat. That’s 100,000 times each day. This constant squeezing can cause small lesions in the artery wall. This triggers a repair process where LDL cholesterol comes in to patch up the damage. Recent research has found that the crux of the problem is the oxidation of LDL cholesterol. Rich in fatty acids, the LDL molecule becomes permanently altered when oxidized by free radicals (overreactive molecules that steal electrons from other molecules). These rancid, oxidized LDL molecules are no longer recognized by the body, so they’re attacked by immune system cells. These immune cells become bloated with the oxidized lipids, accumulate in artery lesions and create plaque in blood vessels. Why is LDL cholesterol being oxidized? First of all, there’s too much of it in the blood, while not enough HDL. Secondly, the blood doesn’t have enough antioxidants to neutralize free radicals. The ingredients in Source Naturals Cholestrex address these specific problems in several ways. Cholestrex also provides nutrients that protect and strengthen blood vessel walls.

    In the typical American diet, 95% of the cholesterol meant for removal is reabsorbed

    Cholestrex Has It All

    Vitamin C helps maintain the health of artery walls because it’s the key building block for collagen and elastin, the primary constituents of blood vessels. Copper is required by the enzyme that weaves together the fibers of collagen and elastin into the matrix that makes vessel walls both tough and flexible. As an antioxidant, vitamin C scavenges free radicals in the blood plasma and also regenerates vitamin E within the LDL molecule. Vitamin E has a critical role as the primary protector of LDL, preventing its oxidation. One molecule of vitamin E can protect 200 molecules of polyunsaturated fatty acids from free radical damage. GTF Chromium is involved in insulin activity and the normalization of blood sugar. Excess simple sugars are converted to triglycerides, the blood fats which can accumulate in artery walls. Lecithin is a component of HDL that emulsifies excess blood fat so it can be more readily transported in the bloodstream to the liver, where it’s metabolized. Vitamin B3 (niacin) assists in the metabolism of fats, and puts an electric charge on red blood cells so they repel each other, which prevents blood clumping. The amino acid, L-Arginine, works to lower serum cholesterol and triglycerides by inhibiting fat absorption.

    Beta sitosterol neutralizes incoming dietary cholesterol

    The Body’s Cholesterol Removal System

    HDL molecules carry cholesterol from tissues throughout the body back to the liver, where it is incorporated into bile salts. These bile salts are sent to the intestines, where they combine with fiber for excretion. One problem with the typical American low fiber diet is that 95% of the bile-bound cholesterol is reabsorbed. Since this is the body’s primary pathway for ridding itself of excess cholesterol, another strategy incorporated into Cholestrex is to maximize the production of bile salts and minimize their reabsorption by increasing levels of fiber. Fiber is a key element of Cholestrex. Its four types of soluble fiber bind with bile salts that are laden with cholesterol to ensure their excretion from the body. Oat Bran & Fiber, Grapefruit Pectin, Psyllium Seed Husks and Alfalfa Seeds also absorb cholesterol from our food, thereby lowering total blood cholesterol. Alfalfa seeds are considered a blood purifier. Beta sitosterol, a plant equivalent of cholesterol, binds to sites in the intestines that would otherwise absorb cholesterol. Cholestrex provides a daily total of 300 mg of beta sitosterol which may, by itself, neutralize 200 to 300 mg of incoming dietary cholesterol by preventing its absorption. Vitamin C, among its many other vital roles, is the key factor in activating an enzyme that will increase the liver’s conversion of cholesterol into bile salts. CHOLESTREX uses bioactive mineral ascorbate forms of vitamin C that will not irritate the digestive system. Working in conjunction with the fiber in CHOLESTREX, Calcium increases HDL, while lowering total serum cholesterol.

    Cholestrex–Intelligent Nutritional Support

    Our generation is fortunate to witness the remarkable progress made by modern science in understanding the body’s complex biochemical processes. As we realize the vital connection between nutrition and cholesterol levels, we are empowered to improve our health and vitality beyond previous standards of wellness. Source Naturals CHOLESTREX. For you and the ones you love.

    Reference:
    1. Drexel, H., et al. “Lowering Plasma Cholesterol with Beta Sitosterol and Diet.” The Lancet 1 (1981): 157.
    2. Grundy, S. M., et al. “Influence of Nicotinic Acid on Metabolism of Cholesterol and Triglycerides in Man.” Journal of Lipid Research 22 (1981): 24-36.
    3. Grundy, S. M. “Oxidized LDL and Atherogenesis: Relation to Risk Factors...” Clinical Cardiology Vol. 16 (Suppl. I), April 1993: 13-15.
    4. Hendler, S. S. “The Doctors’ Vitamin and Mineral Encyclopedia.” New York: Fireside, 1991.
    5 Jialal, I., and C. J. Fuller. “Oxidized LDL and Antioxidants.” Clinical Cardiology Vol. 16 (Suppl. I), April 1993: 16-19.
    6. Kay, R. M. and A. S. Truswell. “Effect of Citrus Pectin on Blood Lipids and Fecal Steroid Excretion.” American Journal of Clinical Nutrition 30.2 (1977): 171-75.
    7. Kirby, R. W., et al. “Oat Bran Intake Selectively Lowers Serum Low Density Lipoprotein Cholesterol Concentrations of Hypercholesterolemic Men.” American Journal of Clinical Nutrition 34.5 (1981): 824-29.
    8. Malinow, M. R., et al. “Alfalfa.” American Journal of Clinical Nutrition 1979: 1810-12.
    9. Mattson, Fred H., Scott M. Grundy, and John R. Crouse. “Optimizing the Effect of Plant Sterols on Cholesterol Absorption in Man” The American Journal of Clinical Nutrition 35 (April 1982): 697-700.
    10. Railes, R. and M. J. Albrink. “Effect of Chromium Chloride Supplementation on . . . Serum Lipids Including High Density Lipoprotein of Adult Men.” American Journal of Clinical Nutrition 34 (1981): 2670-78.
    11. Turley, S. D. and J. M. Dietschy. “The Metabolism and Excretion of Cholesterol by the Liver.” in The Liver: Biology and Pathobiology, I.M. Arias, et al. Raven Press, 1988.
    12. Turley, S. D., et al. “Role of Ascorbic Acid in the Regulation of Cholesterol Metabolism and the Pathogenesis of Atherosclerosis.” Atherosclerosis 24 (1976): 1-18.



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    TopPreviousNext

    Date: May 31, 2005 04:39 PM
    Author: Darrell Miller (dm@vitanetonline.com)

    Acetyl-L-carnitine is truly a mind-body nutrient. It helps synthesize acetylcholine, the brain's principal neurotransmitter responsible for learning and memory. And it is a more bioavailable form of L-carnitine, an amino acid derivative that performs the vital function of transporting longchain fatty acids into the cellular mitochondria where they are oxidized to generate metabolic energy. Supplemental acetyl-L-carnitine supports the activity of brain cells that depend on acetylcholine. It can also reduce the metabolic waste products that damage cells over time. As one of the most important nutrients to help slow the aging process, acetyl-L-carnitine is at the heart of Source Naturals' commitment to empower people to take charge of their own health.

    Acetylcholine is the brain's principal neurochemical of thought. Neurons need it to communicate with each other, especially to create and recall memories. Acetylcholine is also involved in muscular coordination. At neuromuscular junctions throughout the body, it tells muscles when to contract. But the efficiency of cells that use acetylcholine naturally declines with age, partly because of decreased activity of the enzyme that synthesizes this neurotransmitter.

    Neurotransmitter Production

    Acetylcholine is created when the enzyme choline acetyl transferase (CAT) attaches an acetyl group to a choline molecule. CAT activity is heightened by acetyl-L-carnitine, which donates its acetyl group. Acetyl-L-carnitine is made in small amounts naturally in the body, but its production begins to decline in midlife. In well-controlled human studies, supplemental acetyl-L-carnitine slowed the progress of mental decline by notably improving attention and memory. When supplemental acetyl-L-carnitine was combined with lipoic acid (a powerful natural antioxidant), significant improvement in memory was seen in animals. Researchers said that together the two chemicals "tune up" the mitochondria, the energy-producing organelles that power all cells. Mitochondrial decay is believed to be the primary reason for age-related deterioration of cognitive function and energy levels.

    Cellular Energy and Protection

    As the active form of L-carnitine, acetyl L-carnitine efficiently transports long-chain fatty acids into the mitochondria where they are converted into ATP (adenosine triphosphate), the energy molecule. Animal studies suggest that supplemental acetyl L-carnitine has a positive effect on energy generation as well as on the structural integrity of aging mitochondria. By supporting fatty acid metabolism, acetyl L-carnitine also helps reduce lipofuscin, a metabolic waste product composed of damaged proteins and rancid fats. The brown "liver spots" on some elderly hands are composed of this aging pigment that gradually builds up in cells of the heart, liver, brain, and lens of the eye.

    Muscle Performance

    Ninety-five percent of the body's carnitine is found in muscle cells, especially in the heart where mitochondria comprise nearly 50% of a cell's volume. During prolonged exercise, muscles have a high demand for carnitine because fats can account for up to twothirds of the energy burned. L-carnitine supplements can increase exercise endurance and reduce fatigue. Acetyl L-carnitine is also a key nutrient in Source Naturals' legendary neuroceutical formulas MEGAMIND™ and HIGHER MIND™. And because acetyl L-carnitine also generates the basic energy that affects all biological and mental processes, this mind-body nutrient is one of the few nutritional compounds with such a broad range of action in maintaining youthful functioning. Source Naturals ACETYL L-CARNITINE is therefore an essential part of a smart strategy to live well, age well.

    References

    Carta A. and M. Calvani. Acetyl-L-carnitine: a drug able to slow the progress of Alzheimer's disease? Ann NY Acad Sci 1991; 640: 228-232. Hagen T.M. et al. August 4, 1998. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc Natl Acad Sci USA 95(16):9562-6. Liu J. et al. February 19, 2002. Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. PNAS 99(4):1876-81. Spagnoli A.U. et al. 1991. Long-term acetyl-L-carnitine treatment in Alzheimer’s disease. Neurology. 41(11):1726-1732.



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    Composition and Method of increasing Testonsterone...
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    Date: May 17, 2005 04:01 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Composition and Method of increasing Testonsterone...

    Composition and method for increasing testosterone levels

    Abstract This invention provides compositions and methods related to the administration of deer antler, one or more nor-testosterone precursors, and one or more testosterone precursors, to increase testosterone levels, treat sexual dysfunction, improve sexual function, improve energy, enhance feelings of well-being and increase muscle mass in males. This invention also provides for inhibitors of the enzymes aromatase and/or 5-alpha reductase, to support testosterone levels and avoid undesirable metabolites.

    May reduce DHT:

    By using velvet deer antler along with the testosterone and nor-testosterone precursors, the antler promotes youth film testosterone levels while balancing and ameliorating dangerous spikes in these levels. Another embodiment of the invention includes herbs that inhibits 5-alpha-reductase reducing undesirable levels of dihyrotestosterone. Another embodiment includes chrysin, which inhibits aromatase and the production of estrogenic steroids.

    Deer antler (called Rokujo in Ancient Chinese Medicine) is used for its sexual-reinforcing and anti-aging actions. Wang et al., 36(7) CHEM. PHARM. BULL. 2587-92 (1988). Velvet antler is living tissue that grows at a rate of up to 2 cm/day in some species. Cartilage, bone and support tissues such as nerves, blood vessels and hair follicles of the antler also evidence accelerated growth. Antler is the only mammalian organ that regenerates. These features, responsible for the accelerate growth of velvet antler are likely to be caused by either unique regulatory substances or substances found in other tissues but at lower levels. It is believed that factors actually responsible for the rapid regeneration of the velvet antler can explain the powerful health benefits of the product. Specifically, velvet deer antler regulates the adrenal cortex and energy metabolism, promotes sexual function and growth, and strengthens resistance. Its functions fall into the major categories of general body strengthening, healing, promoting blood cell growth and improving immune and cardiovascular function.

    Some of velvet deer antler's key ingredients include lysophosphatidyl choline, with hypotensive activity, phosphatidyl ethanolamines, sphingomyelin, phosphatidyl choline hypothanthene and uridene, with monoamine oxidase (MAO)-inhibiting and anti-aging effects; polyamines spermine, spermidine and putrescine, with RNA polymerase stimulating effects; gangliosides that may promote memory and learning; and anti-inflammatory amino acids. A wide variety of growth factors are also found in velvet, and may be associated with its growth-promoting activity. Tsujibo et al., 35(2) CHEM. PHARM. BULL. 654-59 (1987).

    As taught by ancient Chinese medicine, deer antler tonifies the yang, primarily deficient yang of the kidneys, spleen and heart. Because kidneys are the seat of the basal yang, the most important use of this class of herbs is to tonify the kidney yang, whose principal manifestation of deficiency is systemic exhaustion. Yang deficiency causes impotence, spermatorrhea, watery vaginal discharge, infertility, enuresis, polyuria, wheezing and daybreak diarrhea. Patients with deficient kidney yang very often have decreased plasma thyroid hormone binding proteins, 24-hour urinary 17-ketosteroids, and decreased rate of glycolysis. When treated with tonifiers such as deer antler, these measurements return to normal ranges. BENSKY ET AL., CHINESE HERBAL MEDICINE, MATERIA MEDICA, REVISED EDITION Eastland Press, Seattle, Wash. (1993).


  • Deer Antler Velvet Full Spectrum Planetary Formulas 30Ct

  • Deer Antler Velvet Full Spectrum 60ct



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