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Search Term: " mehionine "
The Benefits of Zinc Supplements and Why OptiZinc is the best Form!   
Date:
November 09, 2022 12:15 PM
Zinc is an essential mineral that is involved in hundreds of processes in the body, including cell growth and function, immune function, and protein synthesis. While it's possible to get zinc from food sources like oysters, beef, and spinach, many people don't get enough from their diet alone and may benefit from taking zinc supplements. OptiZinc® is a patented 1:1 complex of zinc and methionine, the amino acid that is best absorbed by the body. Studies show that OptiZinc® is absorbed better and retained longer than ordinary zinc supplements tested, and resists binding with dietary fiber and phytate, organic compounds that inhibit zinc absorption. The Importance of Zinc Zinc is an essential mineral that plays a role in hundreds of biochemical reactions in the body. It's involved in cell growth and repair, immune function, fertility, and protein synthesis. While most people can get the zinc they need from food sources like oysters, beef, pork, chicken, beans, lentils, nuts, seeds, whole grains, fortified cereals, and dairy products, some people may not get enough from their diet alone and may benefit from taking zinc supplements. Zinc deficiency can lead to a host of problems like hair loss, diarrhea, impotence, eye and skin problems, delayed wound healing, depression, taste abnormalities, and reduced sense of smell. The Best Form of Zinc Is OptiZinc® OptiZinc® is a patented 1:1 complex of zinc and methionine that has been shown to be absorbed better and retained longer than ordinary zinc supplements. Unlike other forms of zinc supplementation which can bind with dietary fiber and phytate (organic compounds found in plant foods that inhibit zinc absorption), OptiZinc® resists binding with these compounds so that your body can more efficiently absorb the zinc. In addition to being better absorbed by the body, OptiZinc® has also been shown to provide antioxidant protection against free radicals. Free radicals are unstable molecules that can damage cells and lead to inflammation. OptiZinc® has also been shown to support healthy immune function. If you're looking for a quality zinc supplement to help you meet your daily needs, OptiZinc® is an excellent option. This patented 1:1 complex of zinc and methionine is absorbed better by the body than other forms of zinc supplementation and provides antioxidant protection against free radicals. It's also been shown to support healthy immune function. All in all, OptiZinc® is an effective way to ensure that you're getting enough zinc in your diet.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6564) L-Methionine: Supports Glutathione Production And More. 
Date:
October 27, 2022 11:28 AM
L-Methionine is an essential amino acid that cannot be manufactured by the body. It must be obtained through diet or supplementation. L-Methionine supports the production of glutathione, and thereby assists in natural detoxification processes. In the body, L-Methionine can also be converted into SAMe (S-Adenosyl Methionine), a compound that supports healthy joints.* Furthermore, the human body relies on ingested sulfur amino acids, such as L-Methionine, for the synthesis of protein, as well as for biologically active sulfur.* L-Methionine and Glutathione Production L-Methionine is required for the production of glutathione, which is a cellular radical scavenger.* This means that it helps to protect cells from damage caused by free radicals.* Free radicals are unstable molecules that can damage cells, and they are one of the main causes of aging.* Glutathione is important for detoxification processes in the liver.* It helps to remove toxins and other harmful substances from the body.* L-Methionine and SAMe Synthesis L-Methionine can also be converted into SAMe in the body. SAMe is a compound that is involved in many biochemical reactions, including those that occur in joints.* SAMe is thought to play a role in joint health by supporting healthy cartilage and joint function.* In addition, SAMe has been shown to help with depression and liver health.* The Importance of Sulfur Amino Acids Sulfur amino acids such as L-Methionine are important for the synthesis of protein in the body. They are also necessary for the production of biotin, a water soluble vitamin that is involved in energy metabolism. Sulfur amino acids are also involved in a number of other important biological processes.* In Summary: L-Methionine is an important amino acid with numerous benefits. It plays a role in detoxification, joint health, protein synthesis, and more. Because the body cannot manufacture this amino acid, it must be obtained through diet or supplementation. Including L-Methionine in your diet can help you maintain good health and vitality.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6537) The Benefits of NOW Clinical Cardio
Date:
September 30, 2022 12:37 PM
If you're looking for a comprehensive way to support optimal cardiovascular health, look no further than NOW Clinical Cardio. This powerful combination of targeted nutrients and botanicals helps promote healthy cardiovascular structures and functions.* With L-carnitine and CoQ10 to support energy production in the heart, hawthorn and MegaNatural®-BP™ grape seed extract to support blood pressure already within the normal range, and MK-7 to help maintain arterial flexibility, Clinical Cardio offers a broad range of benefits for those looking to maintain a healthy heart.* How NOW Clinical Cardio Works NOW Clinical Cardio is a powerful formula that contains a combination of targeted nutrients and botanicals that are known to support optimal cardiovascular health.* The nutrients and botanicals in Clinical Cardio work synergistically to provide a comprehensive approach to maintaining a healthy heart.* L-carnitine is an amino acid that is synthesized in the liver from methionine and lysine. L-carnitine plays an important role in energy production by transporting fatty acids into the mitochondria where they can be used for fuel.* In addition, L-carnitine has been shown to support healthy heart function and protect against oxidative stress.* CoQ10 is another important nutrient for energy production, as it is involved in the electron transport chain in mitochondria.* CoQ10 levels have been shown to decline with age, so supplementation may be especially important for older adults.* Like L-carnitine, CoQ10 has also been shown to support healthy heart function while protecting against oxidative stress.* Hawthorn is an herb that has been used traditionally for centuries to support cardiovascular health. Hawthorn's primary mechanism of action is vasodilation—the widening of blood vessels—which supports healthy blood pressure already within the normal range.* Additionally, hawthorn has antioxidant activity and can help protect the heart from free radical damage.* MegaNatural®-BP™ grape seed extract is a patented extract of whole red grapes that has been shown in clinical studies to help maintain already healthy blood pressure levels.* MegaNatural®-BP™ contains polyphenols—powerful plant compounds with antioxidant activity—which may help explain its beneficial effects on blood pressure levels.* MK-7 is a form of vitamin K2 that is derived from natto, a traditional Japanese fermented food. Vitamin K2 is involved in calcium metabolism and has been shown to promote arterial flexibility by keeping calcium hydroxyapatite out of soft tissues such as arteries.* By promoting arterial flexibility, MK-7 helps maintain healthy blood flow throughout the body.* Conclusion: NOW Clinical Cardio is a comprehensive formula that contains nutrients and botanicals that are known to support optimal cardiovascular health. With L-carnitine and CoQ10 for energy production, hawthorn for blood pressure support, MegaNatural®-BP™ grape seed extract for antioxidant protection, and MK-7 for arterial flexibility, Clinical Cardio offers a broad range of benefits for those looking to maintain a healthy heart. Try it today!* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6476) The Benefits of NOW Calcium Hydroxyapatite
Date:
September 23, 2022 03:57 PM
For those looking for a natural and highly absorbable source of calcium, NOW Calcium Hydroxyapatite is an excellent option. This supplement is derived from Australian, certified BSE-free, young pasture-fed cattle and includes calcium, phosphorus, magnesium, protein, minerals and amino acids. These nutrients are essential for healthy bone formation and upkeep.* Below we'll dive into some of the specific benefits of NOW Calcium Hydroxyapatite. Some of the primary benefits of NOW Calcium Hydroxyapatite include:
Calcium is essential for strong bones and teeth. It also supports muscle contraction, nerve function and cardiovascular health. Phosphorus works with calcium to build bones and teeth and helps the body use carbohydrates and fats. Magnesium plays a role in over 300 biochemical reactions in the body including energy production, muscle contraction, nerve function and blood sugar regulation. Protein provides the building blocks for bones, muscles, cartilage, skin and blood. Minerals such as zinc, copper and manganese are involved in bone formation.* Amino acids such as lysine and methionine are needed for the proper absorption of calcium.* In Summary: NOW Calcium Hydroxyapatite is an excellent supplement for those looking for a natural source of calcium that is easily absorbed by the body. In addition to calcium, this supplement also includes phosphorus, magnesium, protein, minerals and amino acids which are all essential for healthy bones.* If you're interested in supporting healthy bones*, NOW Calcium Hydroxyapatite is a great option.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6459) Zinc monomethionine and aspartate
Date:
January 25, 2014 09:24 AM
What is ZMA?
Importance of ZMA ZMA is of great importance when it comes to immune boosting. Some of the body occurrence could damper somebody’s ability to train well. Zinc supplementation gives appositive effect as it decreases the levels of oxidative stress and it reduces inflammation in the body. Also, the ZMA addition of this supplement to the daily diet since it happens to be one of the nutrients. These nutrients are frequently found in daily consumed foods like crab, oysters, pork shoulder and beef shanks. ZMA boosts the testosterone levels in the body since it is muscle building supplement that has been shown to boost testosterone levels. This substance contains zinc, magnesium together with vitamin B6. The research has revealed that the usage of ZMA supplement increases the testosterone levels for about 30% and the strength could be increased by 250%. The ZMA testosterone boost makes a great progress in weight training. It also develops strength. The presence of this supplement is of great benefit to sleep as it boosts the testosterone hormone that helps in getting enough sleep. The sleep helps muscles by repairing them and giving enough rest. The Magnesium presence could help in building of the lean muscles in from their ass. This gives the muscles enough oxygen as the function and recovering from their workouts and build new muscles. Still edge can be gotten by taking ZMA though zinc and magnesium contain high quantity of multivitamins, a condition called competing nutrients. This condition is by when one nutrient cancels the effect on another nutrient. For the case of weight training, the presence of calcium in your body can cancel out or limit the effects of zinc and magnesium that you ingest through food or a multivitamin. References:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2985) Health Benefits Of Taking L-Carnitine
Date:
November 04, 2013 07:18 PM
What is L –Carnitine
Important in the management of heart conditions Carnitine is important in the management of a number of heart related conditions for example congestive heart failure, diphtheria, chronic chest pain, heart attack and high cholesterol. Studies show that Carnitine indeed is helpful in dealing with a number of heart related diseases. Boosts overall brain function A recent study shows that Carnitine aids in the recovery of stroke among animals. This clearly shows that this amino acid targets the brain cells. It contains nutrients that are highly required by the brain to function properly for example vitamins E, B-12 alpha-lipoic acid and folic acid. Helps in burning body fat Carnitine is a portent fat burner. It is needed in the transportation of fat into cells which will be used for the production of energy in the body. When the Carnitine levels are increased in the body, the body increases the fat burning process and then boosts energy levels in the body. Prevents diabetes This amino acid can prevent diabetes and promotes cardio vascular health. With its antioxidant properties Carnitine eliminates free radicals and also reduces oxidative stress. This is very important in the improvement of your insulin health and also help in fat loss. Improves male fertility Studies show that adequate Carnitine levels in the body are necessary for male fertility. According to the study fertile males had adequate levels of this amino acid it was associated with healthier sperm. While the others who were considered infertile had compromised sperm health and lower Carnitine levels.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2876) Hair Growth Vitamins?
Date:
December 20, 2012 08:09 PM
Keep your hair from falling out Hair and beauty is a trendy industry, which doesn't have any fall back and recession. For a little better hair treatment, you might have to double or triple your budget. So, people living upon a non-stretchable financial background often look for remedies those can be taken in home. Hair fall can be due to shortage of few vitamins too. Few of the vitamins those have active effect upon hair fall are discussed below. Role of several vitamins in hair growth: B vitamins help in maintaining the surface of the hair strands and can be taken by eating beans and eggs. Biotin promotes hair growth whereas Vitamin A aids to the immune system so that hair strands stay healthy and less prone to brittleness. Vitamin C helps enhances blood circulation to the hair follicles and scalp making the hair roots stronger. It is found in fruits in adequate amount. Vitamin E helps in oxygen uptake to the scalp, nourishing the follicles. About Hair Force by KAL: Hair Force by KAL has the exact proportion of ingredients required for healthy hair. In addition to the above mentioned vitamins it has many useful macro and micro elements like zinc, copper, manganese, silica, inositol, L-methionine, choline, MSM, iron etc. These are the basic structural components of the biological composition of hair. Vitamin B ingredients like riboflavin, niacin and folic acid control the brittleness of the hair strands. How does Hair Force by KAL work? The minerals and elements provide support to the molecular structure as they are the core building parts of those bio-molecules. Vitamins keep all desired enzymes and blood circulation to the scalp steady. Few of them also help in tightening the hair follicles. Hair fall is mostly caused by hair brittleness. If all the medicines are taken with time and regular care of the scalp is taken, its guaranteed that significant change in hair fall will appear soon.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2761) The Health benefits of P-5-P
Date:
July 20, 2012 07:51 AM
P-5-P or Pyridoxal-5-phosphate P-5-P or the most commonly called Pyridoxal-5-phosphate is known to be the most active form of the Vitamin B6. This is known to be converted from organic compounds pyridoxal, pyridoxine and pyridoxamine. The Vitamin P-5-P is a coenzyme which support several other enzymes in the body which play a important role in biosynthesis. This also makes optimum use of the vitamin B6 by improving the body metabolism and many other biological process as well. The vitamin B6 traditionally comes in the form of pyridoxine hydrochloride which the body finds difficult to synthesize in its existing state. Hence, this pyridoxine hydrochloride is processed and is formed as Pyridoxal-5-phosphate to help the body to use the vitamin B6 effectively. There are a lot of benefits of the vitamin P-5-P Let us have a look at some of them. Pyridoxal-5-phosphate uses the information from the genes ad helps to produce proteins.P-5-P is also helpful in the formation of hemoglobin, histamine and neurotransmitters and is also helpful in the metabolism of amino acids, fats and glucose.Pyridoxal-5-phosphate also helps in the conversion of dopa which is a useful substance used in the treatment of Parkinson's disease. Dopa is converted to dopamine which is a neurotransmitter which is produced in the brain and is released by the hypothalamus. Food Source The P5P is also helpful in the utilization of the food sources for the formation of energy and also helps in the easy release of glycogen which is the stored energy.P5P also converts glutamate into GABA which is gamma amino butyric acid which is again a neurotransmitter which is known to be found in the mammals. This is found in their central nervous system.The Pyridoxal-5-phosphate also helpful in the process of decarboxylation which is the conversion of histidine to histamine. This also converts SAM-e to propylamine which is known to be a precursor of polyamines.The Vitamin P5P is also responsible to lower the homocystenie levels which are caused by the intake of high amounts of methionine.The Vitamin Pyridoxal-5-phosphate helps in the treatment of irregular heartbeat , which is a condition termed as arrhythmia.This plays a important role in the treatment of myocardial infections. This prevents the blood platelets from sticking to each other which usually causes blood clots.The enzymes produced by the Pyridoxal-5-phosphate also helps in the formation of different kinds of amino acid reactions which keeps the carbon ions stable. This process is very important in the metabolism of the cells.The P5P also helps in the metabolism of the amino acids. Here it helps in converting methionine to cysteine and also converts tryptophan to niacin.Pyridoxal-5-phosphate also plays a vital role in the formation of glucose. This process is known as gluconeogenesis.This also acts a important co-enzyme in the process of glycogenolysis which happens in the liver and muscles and this is known to be a reaction which occurs due to presence of glycogen.The P5P also helps in the formation of antibodies and also assists in the process of hemoglobin synthesis as well. To keep it simpler, the vitamin P5P performs many functions which is very beneficial to the whole human body. The P5P deficiency can also happen in many individuals and even such symptoms are hard to identify. Any person suffering from the P5P deficiency will have symptoms like muscle weakness, irritability or depression. Consulting a physician and taking necessary supplements will help to overcome the P5P deficiency.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2668) What Is Zinc and What AreThe Benefits of Taking OptiZinc
Date:
February 12, 2012 07:34 AM
Zinc is considered to be one of the most essential minerals that have the ultimate capacity to boost the immune health of a human body. Scientific researches revealed that zinc plays a major role in regulating the production of cells in the body's immune system. High levels of zinc can be derived from ginger roots, pecan nuts, oysters, peanuts, oats, peas, turnips, whole wheat grains, almonds and pumpkin seed. Zinc supplementation is getting a lot importance nowadays because of a number of health complications that can arise due to zinc insufficiency. Intake of zinc supplements can help the body gain sufficient amount of resistance against acne, eczema, prostate disorder and even simple colds. Studies show that zinc has the optimum capacity to regulate the level of testosterone in the body which when left uncontrolled can eventually lead to the formation of annoying acne. Zinc also stimulates the body's natural ability to heal chronic infections. Zinc actually aids a number of enzymes that facilitate in collagen synthesis which leads to faster healing of wounds and infections. Zinc is also known for its capacity to strengthen the body's immune system. In fact, it shortens the duration of common colds by enhancing the functions of white blood cells. Low level of zinc in the body makes an individual more susceptible to suffer from a number of health infections. Zinc is scientifically proven to be effective in preventing the development of diabetes. It regulates the production of insulin and helps the blood sugar move into the cells. The mineral is even effective in reducing the risk of suffering rheumatoid arthritis because of its anti-inflammatory properties. Inadequate amount of zinc in the body can lead to growth retardation, loss of appetite, bone degradation, low blood pressure, poor quality and rough skin and loss of sense of taste and smell. Zinc insufficiency can also be major culprit behind the development of weight loss, fatigue, hair loss, formation of white spots underneath the nails and diarrhea. Zinc is also known for its capacity to promote a healthy and radiant skin. The mineral has a direct influence over hormones that control the production of oil, promote optimum cell growth and prevent the development of skin disorders like diaper rash, burns, psoriasis and dandruff. Zinc is a powerful mineral that optimizes cognitive function by enhancing memory and cognition. Optizinc is actually a patented complex of methionine and zinc supplement that absorbs better and retain longer than any other zinc supplement available on the market today. In fact, OptiZinc is considered as the superior quality bioavailable form of mineral zinc. OptiZinc actually increases the availability of zinc in the body that is effective in promoting healthy cell functions which include digestion, reproduction, respiration, growth and development. OptiZinc also promotes a better and efficient brain, vision, nerve and immune functions. It is also capable of neutralizing the effects of damaging free radicals thereby reducing the user's risk of suffering from serious health conditions like cancer. Clinical studies show that OptiZinc works better than any other zinc supplement available on the market today.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2571) Bioperine Promotes Maximum Absorption
Date:
February 06, 2012 06:19 PM
Bioperine Bioperine is an extract from black pepper that contains about 95 percent piperine. Piperine is an alkaloid, the active substance that contributes to nutrients bioavailability and absorption. Bioperine can be combined with other specific nutrients to form different nutritional supplements that can be used for both animal and human consumption. Black pepper is mostly harvested before ripening, dried in the sun and then the extraction process begins. How and why use of Bioperine promotes maximum vitamin absorption Recent research has shown that the use of Bioperine, whose main constituent is piperine, increases thermogenic activity in the body. Thermogenesis is an accelerated metabolic process that takes place in the body cells in which conversion of glucose into energy takes place. An increase in absorption of discount minerals such as selenium and vitamins such as vitamin A has been witnessed to be triggered by the use of Bioperine. Piperine works through initiating the release of catecholamines hormones that stimulate thermogenesis. However, the nutrients should presently available during this time since; the process takes place for a short duration. Piperine improves the necessary conditions of the intestines thus enhancing vitamins absorption. It alters the intestinal epithelial cell wall making it more permeable to vitamins and minerals. In addition, absorption of protein supplements such as those used by people who are on a dietary weight loss program is also increased. Several researchers have also shown that Bioperine has other benefits in the body, these includes the antibacterial properties and anti allergy properties. Experiments prove that use of Bioperine increases vitamin and mineral absorption Several studies on how much piperine promotes nutrients absorption have been carried out hitherto. For instance, an experiment was carried out on the effect of absorption of beta-carotene, vitamin B-6 and selenium which are fat soluble vitamin, water soluble vitamin and mineral in the form of selenomethionine respectively in the presence and absence of piperine. The experiment showed that absorption of these vitamins and mineral selenium increased appreciably when taken with Bioperine. There was 60 percent increase in absorption of beta-carotene and vitamin B-6 while 30 percent absorption was noticed for selenium. The experiment was carried out using 5 milligrams of Bioperine. Another experiment also showed a 30 to 200 percent increase in the absorption of Coenzyme Q-10. Bioperine is the only piperine product to undergo comprehensive health tests and to be patented for the effect of increasing nutrients absorption, more so vitamins and minerals. By creating metabolic changes that require vitamins and minerals, Bioperine creates a nutritional need and then follows by increasing the nutrients bioavailability to meet the need. However, the process takes place in a short period. It is therefore advisable to co-administer minerals and vitamins with Bioperine so that they will be available during the right time for absorption. Unfortunately, research has shown that taking black pepper in its natural form does not yield the same results as those of taking Bioperine. This is mainly because the bioavailability of piperine is not that high in the natural form. Finally, antibacterial and anti allergy properties of Bioperine diversifies its application in medication.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2557) What Vitamins And Minerals Are For Mental Alertness?
Date:
August 29, 2011 10:33 AM
There are many vitamins and minerals which can help improve the health and functioning of the nervous system. Vitamins and minerals are significantly involved in many biological processes of the body. It influences the activities of the organs of the body including the brain. In fact, deficiencies on vitamins and minerals may result to psychological or even psychiatric symptoms in certain individuals. People with psychiatric problems are also prescribed with vitamin and mineral supplements which serve as one of its conventional treatment. The vitamins and minerals which are good for the improvement of brain function and improvement of mental alertness are the following: 1. THIAMINE OR VITAMIN B1. Generally, insufficient amount of this enzyme may result to mild psychiatric symptoms. Studies revealed that people with inadequate amount of this vitamin has the symptoms of fearfulness, anxiety, depression, agitation and behavioral instability. This vitamin is necessary for the activity the body’s enzyme called pyruvate dehydrogenase. This enzyme is required for the conversion of pyruvate to acetyl – coenzyme A. If pyruvate is not catalyzed into acetyl – coenzyme A, the excess pyruvate in the body might be converted into lactate which can cause muscle pains and also psychiatric symptoms such as anxiety. Deficiency of this vitamin must be suspected when the person is alcoholic or malnourished. 2. RIBOFLAVIN OR VITAMIN B2. This vitamin is closely associated with major depression in relation to oxidative stress. Riboflavin is required for the metabolism of protein, fats and carbohydrates. The building blocks of these macronutrients are important for the maintenance of brain health and proper functioning of the nervous system. It can improve the energy levels and functioning of the brain, thus improving an individual’s mental alertness. 3. PYRIDOXINE OR VITAMIN B6. Studies show that low level of vitamin B6 is directly related to depression. Inside the body, pyridoxine is converted into its biochemical active form called pyridoxal phosphate which is important for mental alertness and brain functioning. Pyridoxine acts as a coenzyme involved in the synthesis of brain chemicals such as serotonin, dopamine and gamma aminobutyric acid (GABA). This vitamin is also involved in the metabolism of carbohydrates and amino acids which are essential for boosting energy levels. 4. COBALAMIN OR VITAMIN B12. Deficiency of this vitamin is closely related to decrease mental functioning. Vitamin B12 is a cofactor of the enzyme methionine synthase which is important in the conversion of homocysteine to methionine. This is required for the production of energy in fatty acids and proteins which is important for the methylation reactions of brain chemicals. 5. VITAMIN C. This vitamin is considered to be a cofactor of the neurotransmitter dopamine and is involved in the conversion of dopamine to norepinephrine. These brain chemicals are important for the maintenance of proper mental alertness. 6. FOLATE. Decreased mental alertness and depression is a common symptom of low levels of folate in the body. This mineral is involved in the methylation and synthesis of DNA. It is important for the development of brain function and improvement of mental alertness. 7. MAGNESIUM. This mineral is involved in many reactions of the body. Individuals with decreased mental alertness are found to have low levels of magnesium in their cerebrospinal fluids. 8. ZINC. This is a mineral which is important in the catalyses of many enzyme sin the body. It is found in high amount in the brain which is important for nervous activities.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2411) What are the Essential Amino Acids we must get from our Diet to Survive?
Date:
August 17, 2011 12:13 PM
Amino acids or the building blocks of protein are very important in overall functioning of the body. Proteins, to mention, are responsible for the build up of most of our body parts specifically our muscles, ligaments, tendons, organs, tissues, glands, nails and hair. Moreover, the repair and preservation of those parts still rely on proteins. Amino acids can be of two different forms which are the non-essential and essential. On this selection, we will be focusing more on the latter. Essential amino acids are those which cannot be produced by the body therefore it has to be supplied through our diet. This category of amino acids includes tryptophan, lysine, methionine, valine, leucine, isoleucine, threonine and phenylalanine. Tryptophan, which is a precursor to serotonin and melatonin, can be acquired from peanuts, meat, turkey, fish, milk, dried dates, cottage cheese, banana, oats and chocolates. A deficiency of this can bring up serious neurological problems, depression, anxiety and sleeping difficulties. Another essential amino acid is methionine. The production of sulfur and other compound needed for a healthy growth and metabolism depends on the presence of this amino acid. Fish, whole grains and dairy are its sources. Lysine, which is effective in the treatment and prevention of herpes, is present in soybeans, green beans, lentils, spinach and amaranth. Low levels of lysine can also compromise the levels of niacin and this leads to pellagra. Tissue healing, muscle metabolism and keeping the equilibrium of nitrogen levels in our body are the functions of valine. It has proven to be efficient in the treatment of liver and gallbladder disorders. Deficiencies that results from drug addiction are can also be reversed by this amino acid. Its sources are peanuts, soy proteins, dietary products, grains, meat and mushrooms. Leucine can be obtained from chicken, fish, cottage cheese, lentils, peanuts and sesame seeds. It functions in muscle protein build up and is the main medium in tissue building process. Inability to acquire such makes a person prone to protein wasting since leucine, together with valine and isoleucine, serves as energy and protein reservoirs. In boosting energy levels, blood sugar regulation, muscle build - up and repair as well as hemoglobin development, isoleucine has shown its relevance. Its dietary sources are fish, poultry, beef, dairy, eggs, lentils, seeds, soy, almonds and wheat. Isoleucine deficiencies may result into neurological disturbances such as confusion, depression, irritability, fatigue, headache and dizziness. Threonine is significant in synthesis of antibodies. Beans, nuts, seeds, dairy, poultry, eggs and beef are rich in threonine. A low level of this amino acid causes disorders of the skin and weakness. Adrenaline and noradrenalin which are stimulates the central and peripheral nervous system requires phenylalanine to perform their function. Phenylalanine can be acquired from peanuts, seeds, almonds, lima beans and dairy. Liver damage, weakness, skin lesions, lethargy and slowed growth are results of its deficiencies. In summary, our body needs networks of essential amino acids for its proper functioning. Eating healthy foods and living a healthy lifestyle is the secret towards maintaining your optimum general health.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2396) How Does N-Acetyl L-Carnitine Help Energy Levels?
Date:
August 03, 2011 11:47 AM
N-Acetyl L-Carnitine And Cellular HealthN-Acetyl L-Carnitine refers to the ester form of the organic compound carnitine. It has been linked to many different health benefits largely owing to the fact that it is quite ubiquitous at the cellular level. It plays an important role in keeping cells in prime working condition as derivatives of this compound protect cells from oxidative stress as well as contribute to reactions responsible for energy production. Increases Cellular Energy The biochemical energy that powers cellular activities comes in the form of adenosine triphosphate. All types of tissues in the human body are capable of manufacturing this chemical compound, the reason why it is often called the molecular unit of currency. The human diet provides the biological precursors of cellular energy, but adenosine triphosphate is obtained from the sugar glucose more often than not. Cells make use of N-acetyl L-carnitine in the synthesis of adenosine triphosphate. Research has shown that the presence of acetylated carnitine appears to modulate the metabolic processes leading to the manufacture of cellular energy. In recent years, endurance athletes and body builders have relied on supplements that contain this compound to boost their energy levels. Human trials support its safety. Aids Healthy Metabolism Glucose is the principal precursor of chemical energy in the form of adenosine triphosphate. Complex carbohydrates are digested to simple sugars such as glucose, which enters the circulation. Insulin is a hormone that induces the uptake of glucose by cells, which convert glucose to usable energy. Studies have observed that N-acetyl L-carnitine improves the activity of insulin and consumption of glucose. It is a well established fact that carnitine is involved in the breakdown of fats, waxes, and sterols, and their consequent utilization in the production of cellular energy. For this reason, N-acetyl L-carnitine is marketed as a nutritional supplement that promotes fat loss and aids weight loss. Human trials have noted that regular intake upregulates the conversion of fats and other lipids to adenosine triphosphate. Prevents Oxidative Stress Lysine and methionine are amino acids that act as immediate precursors of carnitine, which the body synthesizes on a regular basis to support a number of physiological functions. In particular, carnitine plays a major role in supplying cells with a steady supply of chemical energy during intense physical exertion. At the same time, they protect the cells from the harmful effects of reactive oxygen species. N-acetyl L-carnitine is a very good source of carnitine as it is widely believed to be more bioavailable than L-carnitine. It adds to the number of carnitine in cells, boosts energy levels, and combats free radicals and other reactive oxygen species. Free radicals are natural by-products of energy production, and thus carnitine produces a twofold effect. It promotes cellular longevity and raises chemical energy.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2386) Using SAMe for Depression
Date:
June 04, 2011 10:15 AM
SAMe, or S-adenosyl-L-methionine, has been promoted for the treatment of depression and various physical conditions. It is believed to help improve the feeling of well-being and mood, and its use in treating depression is likely connected with that. A typical study of the many carried out involved 30 subjects taking regular antidepressants but still suffering depression. They were given 0.8 grams SAMe for 2 weeks and then 1.6 grams for 4 weeks. Improvement was obtained in 50% cases and complete remission of symptoms in a total of 43% of the subjects. In another test on 28 subjects, the improvement equaled that of prescription antidepressant drugs. These significant findings render this over the counter supplement (in the USA) worth taking for anybody that has either no effective help from their regular treatment, or would prefer to try a natural biochemical than a synthetic drug for their condition. You are recommended to refer to your doctor, however, if you intend changing your treatment.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2321) Improve Immune System, Digestion, Muscle Recover, The Skin, And More with OptiZinc
Date:
May 31, 2011 03:45 PM
Zinc And Your Health.OptiZinc is a patented zinc supplement in which the trace element zinc is bound to the essential amino acid methionine. It is especially formulated to guarantee absorption of zinc at a rate far superior to other zinc supplements. Hence, it is commercially touted to be the form of zinc best suited for people diagnosed with zinc deficiency. Decades-long studies have recorded noticeable effects on health. Increases Immune Function Zinc has long been tied to the immune system. For one, all white blood cells that contain granules in their cytoplasm secrete zinc at certain immune responses. In addition, several other cells in the employ of the immune system utilize zinc signaling for cell-to-cell communication. OptiZinc increases availability of elemental zinc for use by immune cells and modulates immune function in the process. Promotes Healthy Metabolism Zinc is one of the trace elements that are pervasive at the cellular level. Proteins that belong to all enzyme classes necessitate the presence of zinc to activate their catalytic activities. The scientific community has long come to a conclusion that zinc is absolutely necessary for healthy metabolism, and thus the daily zinc needs of the body must be met to avoid impairment of physiological functions. Aids Digestive Processes OptiZinc is particularly good for the gastrointestinal tract. It contains up to 200 per cent of the recommended daily value for zinc to ensure absorption and aid digestion at the same time. Zinc ions are directly involved in the antimicrobial activities that take place in the intestines. Digestive enzymes that contain zinc are responsible for the breakdown of peptide bonds of proteins during digestion. Accelerates Muscle Recovery Supplementation of OptiZinc is likely to benefit people who engage in regular physical activities, especially athletes and bodybuilders. This formulation of zinc contains an equal ration of zinc to methionine, an essential amino acid necessitated in the biosynthesis of many other amino acids. OptiZinc speeds up the recovery of skeletal muscles after subjected to intense exercise. Improves Skin Conditions It is well established fact that a deficiency in zinc leads to higher incidence to acne. Severe cases even result in progressive hair loss and skin ulcer formation. These skin conditions are in fact a symptom of a metabolic disorder affecting the uptake of zinc, whether congenital or acquired. OptiZinc have been reported to alleviate zinc deficiency-induced skin problems and promote healthy-looking skin. Scavenges Free Radicals OptiZinc is a noted free radical scavenger. Its efficacy in preventing oxidative stress has been associated to the prevention of a diverse variety of illnesses, which include eye problems, prostate inflammation, and neurodegenerative diseases. This special formulation of zinc delivers the highest absorbable amounts of zinc into the systemic circulation to effectively prevent radical damage.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2313) Taurine - Essential or Non-Essential Amino Acid - You Decide?
Date:
February 17, 2011 10:56 AM
Amino Acid Taurine Is Essential For More Than You ThinkTaurine is an organic compound with acidic properties, which is synthesized in the pancreas in adults, but an essential amino acid in infants. Many neutraceutical products for infants are fortified with taurine, inasmuch as some newborns do not have the enzymes required to synthesize taurine. Taurine deficiency in adults results from deficiencies in other organic compounds, notably methionine and cysteine, which are its immediate precursors within the body. Helps in Brain Development It has long been postulated that taurine plays an important role in the human brain, especially in infants, protecting the nerve cells from possible neonatal damages. Taurine continues to affect the nervous system as we age, acting on gamma-aminobutyric acid, or GABA, and consequently enhances inhibitory synaptic transmissions. In addition, taurine is alleged to stimulate continuous activation of synapses characteristic of long-term potentiation, which memory and learning ability stem from. Stabilizes Glucose Levels Taurine is a powerful inhibitor of glycation, a process by which sugar molecules attach themselves to other biomolecules without the aid of enzymes, and thus subsequently impair the functions of these biomolecules. This process may take place inside or outside the body, but the substances that result from this process, which are referred to as advanced glycation end-products or AGEs, contribute to the formation of a number of major disorders in later life such as cardiovascular diseases, Alzheimer’s disease, age-related deafness and blindness, and cancer. Taurine keeps the cells from taking up AGEs from the blood, which is slowly excreted in the urine. Regulates Adipose Tissues It has also been observed that dietary taurine influences the metabolic pathways that give rise to the formation of adipose tissues, the fat reserves of the human body. These fat depot appear anywhere in the body, but are commonly tied to the subcutaneous fats, those that we see on the belly, chest, arms, and thighs. Moreover, body fat percentage has been an indicator of obesity, which is central to the use of taurine in regulating adipose tissues. Influences Lipid Absorption Taurine is a major component of bile, the fluid produced by the liver, stored in the gallbladder, and secreted in the small intestines to aid in the digestion of triglycerides, cholesterol, and other lipids. Also, several studies point to the effect of taurine on the binding of proteins to lipids to form lipoproteins, compounds that have been notoriously labeled as bad cholesterol. Not surprisingly, taurine has been suggested to maintain healthy levels of blood cholesterol and prevent cardiovascular diseases. Fights Oxidative Stress Sodas have become a part of our daily diet today, but little did we know that they are risk factors for oxidative stress, the continued peroxidation of cellular structures. Fructose in sodas and other sweetened beverages is the most dangerous of all sugars, inasmuch as it releases by-products called AGEs, which are highly reactive to oxidation. AGEs do not get excreted right away and are instead absorbed by cells, leading to irreversible damages to neuronal and vascular tissues in later life. Intake of taurine removes this problem. Have you had your Taurine Today?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2239) L-Cysteine
Date:
May 08, 2009 10:00 AM
L-Cysteine is what is known as a non-essential amino acid, meaning that it can be biosynthesized by the body and hence not an essential part of your diet. Due to its possessing a thiol side chain, it is termed a hydrophilic amino acid with an affinity for aqueous systems. Because of this it is relatively highly reactive, and is therefore an important component of a large number of enzymes and proteins. Although, after all, it is not an essential amino acid, deficiencies can occur in the young and in the old, and also in those suffering certain metabolic diseases. Dietary sources include high-protein foods such as chicken, turkey, pork, dairy products and vegetables such as cereals, broccoli, garlic and onions. The biochemistry of this amino acid begins with another amino acid known as serine, and also methionine. The latter is fist converted to homocysteine, which is then combined with serine to form cystathionine. This is then converted into cysteine and alpha- ketobutyrate. The thiol group is highly reactive and gives cysteine its biological properties. L-Cysteine possesses strong antioxidant properties due to the thiol group which easily undergoes redox reactions. However, it is for its detoxification effect on the body that the amino acid is mainly taken as a supplement. It is, therefore, these properties that we shall discuss first. Cysteine can reduce the toxic effects of alcohol, such as a hangover or the more serious liver damage. The by-product of alcohol metabolism that does most damage and is responsible for the majority of the negative after-effects of excessive alcohol consumption is acetaldehyde. L-Cysteine converts acetaldehyde into the more acceptable acetic acid, and so prevents the aldehyde from having too much of a negative effect on your health and well-being. However, the results obtained from such studies have been from animals only, and the therapeutic effects of cysteine have not yet been tested on humans. What has been tested and is known is that L-cysteine is effective in the detoxification of heavy metals in the body. A common source of heavy metal toxicity is mercury from amalgam fillings in the teeth. Although the Environmental Protection Agency (EPA) declared in 1989 that dental amalgams are a hazardous substance under the Superfund law, many people still have them in their mouths. The thiol group and L-cysteine has a high affinity for mercury and other heavy metals, as previously stated, and a supplement can be used to remove from the body any mercury leached from mercury-based tooth fillings. It can also be used to bind to copper, lead and cadmium. Lead and cadmium are particularly toxic to the human body, and even though lead is no longer used in plumbing or paints, and cadmium in toys or paints, there are still many sources of these two heavy metals available that can lead to human toxification. An L-cysteine supplement can be used to remove these heavy metals from the body. Any proteins containing cysteine will tightly bind heavy metals such as lead, cadmium, molybdenum, cobalt and mercury, and allow them to be excreted by the body in the usual fashion. This direct involvement in heavy metal detoxification is a very useful property of this amino acid. Another detoxification application of L-cysteine is in direct involvement in protecting cellular glutathione levels, and also the prevention of the death of liver cells by acetaminophen poisoning. The latter is of particular interest to many people since acetaminophen is better known as paracetamol, and since this is a freely available over-the-counter drug, overdoses are not unknown. The result of an overdose is the necrosis of liver cells, with eventual liver failure and death. The treatment of choice is N-acetylcysteine. If used within 10 hours of the overdose it is extremely effective, and even from 16 to 24 hours it is better than other controls. It is believed that the acetylcysteine liberates cysteine which, when available to the liver, enables the biosynthesis of glutathione. Glutathione can then maintain the production of the fifth metabolite required for the specific detoxification of the paracetamol/acetaminophen. L-Cysteine is also an essential component in the biosynthesis of coenzyme A, an enzyme essential for the production of energy from fats and carbohydrates. It is also a very important component of hair, from which it is commercially produced. Without an adequate intake of L-cysteine the growth of healthy hair would not be possible. There are several supplemental uses of L-cysteine including the treatment of bronchial conditions for which the amino acid can help to liquefy and clear mucus from the airways and lungs. It is also used to protect against side effects of chemotherapy treatment of cancers and for medical treatments for excessive exposure to radiation. However, there are certain situations in which L-cysteine should be avoided when at all possible. Diabetics should not use it, and neither should those suffering from cystinuria, whereby large quantities of amino acids, including cystine, are excreted in their urine. L-cystine, incidentally, is formed by oxidation of L-cysteine. Paradoxically the amino acid is one of the several hundred additives made to tobacco by the cigarette companies. Although, as with the majority of tobacco additives, its purpose is unknown there are two possible reasons for its inclusion. L-Cysteine is a known expectorant, so it could be added to promote the expectoration of mucus in the lungs which is promoted by smoking, and it also increases the production off the antioxidant glutathione that is depleted in smokers. There are several other non-medical uses for the amino acid, but it is for is its detoxification properties that it is most used as a supplement. However, because it is largely derived from human hair or duck feathers, it may not be classed as kosher or halal in spite of many claims made to that effect, though the more expensive source of microbial fermentation from corn sugar can be. The substance is recognized as safe by the FDA, and must be labeled as L-cysteine when it is present in a preparation intended for its therapeutic effects. Keep in mind however, that it should be avoided by diabetics.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2005) L-Carnitine
Date:
May 07, 2009 05:45 PM
L-carnitine is amino acid essential for the metabolism of fats into a form of energy necessary for extended aerobic activity. Originally discovered in Russia, and Germany a year later, the structural formulation of carnitine, as it is correctly known, was determined in 1927, although it is physiological and biochemical activity was not understood until the 1960s. The amino acid is biosynthesized in the liver and kidneys from lysine and methionine. The vitamins niacin, B6, C and iron are essential for this reaction to take place. However, the supply of L-carnitine has to be supplemented by the diet, good sources being dairy products, red meat, nuts and seeds, pulses and fruits such as apricots, bananas and avocado. Most of the L-carnitine supply of the body is stored within the muscle tissue. However, it is not unusual for conditions to arise making it difficult for the body to obtain all the carnitine required. L-carnitine enables fatty acids to be transported into the mitochondria, where cell metabolism occurs. The biochemistry is discussed below, although in simple terms the amino acid allows body fats, in the form of triglycerides, to be made more readily available for the generation of energy required for extended exertion. In this way, body fats can be used for energy and the supplies of glycogen stored by the liver can be retained for emergency use. By providing the energy for endurance and stamina in this way, carnitine makes use of an otherwise unavailable energy source, and has the added benefit of reducing body fat stores and reducing strain on the heart. Although there is generally a plentiful supply of L-carnitine available in a healthy diet, supplementation can ensure that a deficiency does not occur. Supplements are available in the form of L-carnitine or its acetylated derivative, acetyl L-carnitine. In order for fatty acids to be used in the production of energy, their long-chain acetyl groups have to get inside the mitochondria where they are oxidized to the acetate to be used for the production of energy via the Citric Acid or Krebs cycle. In order for the biochemistry to take place, fatty acids must be rendered suitable for binding to the carnitine molecule. The chemical grouping with a good affinity for L-carnitine is the acetyl or acetyl group, available in the molecule acetyl coenzyme A (CoA). The free fatty acid, therefore, is attached to coenzyme-A by means of a thioester bond, catalyzed by means of the enzyme fatty acetyl-CoA synthetase. The reaction is then completed by means of in organic pyrophosphatase. In this way, the fatty acid in the form of an acetyL-carnitine derivative can be transported through the mitochondrial wall. This transportation takes place by means of several steps. These are: 1. As explained, the acetyl-CoA is attached to L-carnitine by means of the enzyme carnitine acetyltransferase I. This enzyme is conveniently located on the outer mitochondrial membrane. 2. The enzyme carnitine-acetylcarnitine translocase helps the acetyL-carnitine through the membrane. 3. Another enzyme, carnitine acetyltransferase II, located on the inner mitochondrial membrane, converts the acetyL-carnitine to acetyl-CoA, liberating the carnitine which returns to the muscle mass. L-carnitine is the only known substance that allows fatty acids to cross the mitochondrial membrane, and therefore deficiencies must be avoided. Another way in which carnitine is used in energy production is in the Krebs cycle itself. Part of this cycle involves the conversion of guanine diphosphate to the higher energy form guanine triphosphate. In this way energy can be stored in much the same way as it is in the conversion of ADP to ATP. Succinyl CoA is involved in this conversion, and one of the by-products of it is a corresponding succinate, that is then converted to a fumarate by the action of L-carnitine fumarate. Carnitine, therefore, has two parts to play in the production of long-term energy from the fatty acids contained in body fats. Since the fatty acid triglycerides contained in body fats are a major source of energy in the heart and skeletal muscles, it is easy to understand how L-carnitine is believed to lead to the increased energy levels required for stamina and staying power. A major reason for its effect on longer-term or extended energy requirements is that in enabling stored body fats to be used for immediate and longer-term energy requirements, L-carnitine allows emergency glycogen stores to be retained for use once immediate fatty acid supplies or those of carnitine have been depleted, and so allows the energy supply to be extended even farther. Research has also suggested that the amino acid can possibly be used to treat liver and kidney disease, diabetes and chronic fatigue syndrome. As with many supplements, the question is often asked how does L-carnitine work in practice as opposed to the claims made for it by the supplement providers? Recent research indicates mixed results, but sufficient to justify its use. It is generally accepted that a supplement is necessary when there is a deficiency, but once that deficiency has been corrected further intake is unnecessary. However, it is also believed that during long and extended periods of exercise a carnitine deficiency does occur as L-carnitine is used up, and the supplement is necessary to ensure sufficient energy supply throughout the period of exercise. There has also been a case reported in the Journal of Clinical Neurology (Negoro, Tsuda, Kato & Morimatsu, 1995) where a deficiency, caused by anorexia nervosa damaging the liver to the extent that it was unable to synthesize L-carnitine, was remedied by means of an oral supplement. Studies on endurance athletes have been mixed, ranging from no effect to L-carnitine being found to promote weight loss. Carnitine has no unknown harmful side effects, and has been studied for medical applications other than as an energy supplement. For example it possesses extensive antioxidant properties, and can be used as a supplement against oxidative stress and the prevention of the lipid peroxidation that is a precursor to atherosclerosis. Its use in osteoporosis and reducing bone mass is also being studied. The concentration of L-carnitine diminishes with age, and affects fatty acid metabolism in a number of tissues. Bones are particularly affected since they require continuous reconstruction. Without detailing the biochemistry involved in this, administration of carnitine helps to reduce the speed by which this occurs. Trials are so far been carried out only on animals. In studies on both healthy volunteers and patients with type II diabetes, L-carnitine was found to improve storage of glucose in both groups, although its oxidation increased only in the group with diabetes. Other studies carried out include improving the function of neurotransmitters in the brains of elderly patients and in the treatment of Alzheimer's and Parkinson's disease, and other neurological disorders. In conclusion then, although the jury is out on the use of L-carnitine is an energy-giving or weight-loss supplement, it appears to be effective where the body's stores of carnitine could be depleted such as with long-term exercise, natural deficiencies or deficiencies caused through age. It is also under study in the treatment of various medical conditions. On balance, it would appear that the prospective benefits of L-carnitine render it worthy of use.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2004) L-Methionine
Date:
May 02, 2009 11:41 AM
Methionine is an essential amino acid, meaning that it is not synthesized by the body, and so has to be taken as part of your diet. It also contains sulfur, one of two sulfur-containing amino acids that can form proteins, the other being cysteine. It is a precursor for taurine, which is an aminosulphonic acid, and not strictly an amino acid, which together with cysteine supports the health of your cardiovascular system and helps to eliminate toxins from the body. Maintenance of Cell Membranes It is also an important intermediary in the maintenance of cell membranes. Phospholipids are fat-soluble components of the cell membrane, phosphatidylcholine being a very important example. Also known as lecithin, this substance is derived from choline, itself biosynthesized in a chemical pathway involving S-adenosylmethionine. This substance is made in the body from ATP (adenosine triphosphate) and methionine with the help of the enzyme methionine adensosyltransferase. Known as SAM (or SAM-e), S-adenosylmethionine employs a number of metabolic pathways in its reaction, though generally aminopropylation, transmethylation and transsulfuration. These add aminopropyl, sulfo and methyl groups to a number of substances, the most common being the methylation of proteins, nucleic acids and lipids. Phosphatidylcholine is produced by the enzyme-catalyzed sequential methylation of phosphatidylethanolamine, SAM donating the methyl groups. The maintenance of the integrity of the cellular membrane by phosphatidylcholine is critical to all of the basic processes in human biology, including communication between cells, flow of information and bioenergetics. A by-product of this reaction is homocysteine, formed in the liver from the S-adenosylhomocysteine that SAM is changed to after donating methyl groups. Excess homocysteine in the blood can create the risk of myocardial infarction and cardiovascular disease. SAM is also of use in the treatment of depression and of arthritis. Muscle Development Creatine is a substance well known to athletes as being useful in provide short-term energy for high-intensity training. Although available in the diet, about 50% creatine used by the body is biosynthesized from methionine and two other amino acids, glycine and arginine. It allows a burst of energy lasting about 10 seconds, carried out without the use of glycogen reserves or fatty tissue. Glycine and arginine combine to release ornithine as a by-product, and form guanidino acetate. SAM donates a methyl group to the latter to form creatine, about 95% of which is then stored in the skeletal muscle tissue. The stored creatine phosphate has the effect of allowing the muscle cells to hold more water, which also enables an enhanced level of protein synthesis, and hence an increase in muscle bulk, which also results from the increased blood flow resulting from the short-term high-intensity exercise that creatine allows. Creatine can also increase the levels of MRF4 (myogenic transcription factor), resulting in an increasing in the myonuclei provided by satellite cells to damaged muscle tissue, that not only repair damaged muscle fibers, but also increase their ability to grow. Detoxification of the Liver Substances that help the liver to process fats, or lipids, are known as lipotropic, and the important lipotropics in human biochemistry are imositol, betaine, choline and methionine. They prevent fat from accumulating in the liver, and methionine is also useful in its effect of glutathione. This is a substance that helps the liver to neutralize toxins, such as excessive doses of acetaminophen, and its supplies are regulated by methionine. Methionine and Autism Research into autism is closely studying the Methionine/Glutathione Transsulfuration Pathway. This pathway is a very important biochemical means of detoxification, whereby toxins are methylated and then excreted. This pathway seems to be disrupted in autistic individuals. Not only that, but disruption can lead to oxidative stress which results in many health problems. An example of this is the build-up of the oxidant homocysteine when there is insufficient Vitamin B6 to convert it into cysteine. This has been discussed previously, and is discussed again below. Miscellaneous Benefits Although research is in its infancy, it appears that AIDS sufferers also have decreased levels of methionine in their blood. It is believed that the process of AIDS could be linked to this, particularly the dementia that can occur as a result of the deterioration of the nervous system. It is also hoped that it can help with some symptoms of Parkinson's disease, and pancreatitis. Initial research into this use of methionine has been very promising, as are studies into its use for urinary tract infections. It appears to operate like cranberry in this respect, preventing bacteria from attaching to the cell walls and multiplying in the urinary tract. Methionine is believed to be essential for the formation of collagen, and for healthy pliable skin, hair, nails and other forms of connective tissue. For this reason it is often used as a supplement for the treatment of arthritis, although an excess should be avoided for reasons discussed above. S-Adenosylmethionine generates homocysteine during the biosynthesis of phosphatidylcholine, and this can cause cardiovascular problems. So stick to the recommended doses when you use methionine as a supplement. Used properly, and according to instructions, it offers many health benefits, and can also be used to bulk up your muscle tissue and give increased energy when you need it most. Dietary sources include fish, eggs, lentils, onions, garlic, meat, seeds, spinach and yoghurt. A good supplement would be from 800mg - 1000mg per day, and is best taken along with a B vitamin complex, or at least folic acid and vitamins B6 and B12, in order to prevent the increased generation of homocysteine. Methionine also promotes the excretion of estrogen, so is a possible supplement for women on oral contraceptives that lower the production of this hormone. The elderly might also benefit from a supplement although, if taken for any specific condition, your health professional should be consulted first, as they should be for any supplement. Nevertheless, methionine is a very useful supplement, and can be taken to prevent a large number of conditions. Research is continuing on its effect on AIDS patients, and Parkinson's, and it is hopeful that it will one day be recommended to help people suffering from these conditions.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2002) Protect The Liver with Glutathione And Cysteine
Date:
April 23, 2009 01:54 PM
The tripeptide L-glutathione is synthesized in the body from L. glutamic acid, L-cysteine and glycine, a reaction that can occur in any cell of the body although it is essential that it also occurs in the liver. Should glutathione concentrations drop, they can be increased by supplementing with cysteine or any other of the three amino acids that are used in the biosynthesis of this important if substance The tripeptide exists in two forms: the reduced form (GSH) which contains a sulfhydryl (SH) functional group attached to the cysteinyl part of the molecule, and the oxidized form glutathione disulfide (GSSG). As electrons are lost from the reduced form, two molecules combine to create a dimer formed by a disulfide bridge, the process which can be reversed through reduction of the GSSG. Such electrons are lost during its reaction with free radicals, in which the free radicals are neutralized by the donation of an electron from the oxidized version of glutathione. The definition of a free radical is a molecule that is lacking one electron from an electronic pair. Its prime purpose is then to steal an electron from the nearest molecule to it. In doing so, it can not only destroy that molecule, but also destroy body cells and lead, not only to premature aging, but also to some potentially fatal conditions. It is an unusual peptide in that it involves a link between the cysteine amino grouping and the carboxyl functional group of the glutamic acid. It is a powerful antioxidant, acting as an effective free radical scavenger and protecting the body cells from the effects of free radical oxidation. However, it is on its detoxification effect in the liver that we shall focus here prior to discussing some other uses to which the body puts glutathione in its two manifestations. Much of the detoxification is connected with the thiol group in the molecule. Take mercury for example. The thiol grouping forms a strong Hg-sulfydryl chemical bond within the liver, in the form of a glutathione-mercury chelate. In this form mercury is unable to exert any toxic effect on the body and can be excreted in the normal manner. The same reactive pathway is followed by other heavy metals that can bond to thiol groupings. In this way L-glutathione can protect the liver from the effects of a number of toxic heavy metals such as cadmium and chromium. This is an important property of the amino acid, particularly in industrial and urban environments where the population is more prone to exposure to heavy metals than their rural counterparts. However, the end result on the glutathione is that it is removed from the body, and, particularly with city dwellers, a supplement may be required to maintain a healthy concentration of this amino acid in the body and in particular in the liver. Therefore, although L-glutathione is not considered an essential amino acid, in that it is biosynthesized within the body, a supplement is sometimes required, particularly by those who live in large cities. It is important to consider the form in which the glutathione supplement is administered. This is because of the presence of gamma-glutamyltranspeptidase within the digestive system. This enzyme appears to destroy L-glutathione before it can be absorbed in the intestine so normal oral forms of supplementation are likely to be ineffective. Possible forms of effective administration include buccal (between the cheek and teeth) and hypodermically. An alternative means of supplementation is to take substances such as selenium, methionine, alpha-lipoic acid, vitamin C and glutamine that stimulate the biosynthesis of glutathione. Also, since the substance utilizes the raw materials of L-cysteine, glutamic acid and glycine in its intracellular production, supplementation with these amino acids should also help to produce L-glutathione. That said, let's return to its antioxidant properties and its effect on the liver that contains the largest stocks of glutathione in the body. It is generally regarded as the most important antioxidant in the body. It protects cellular cytoplasm from oxidation by reducing disulfide groups and maintaining a highly reducing environment within the cytoplasm. It reacts with hydrogen peroxide and other oxidative agents, and is converted to the oxidized form GSSG. It is then reduced back to GSH through the combination of the reducing agent and an enzyme. The reducing agent is nicotinamide adenine dinucleotide phosphate (NADPH), the enzyme being glutathione reductase. The implications that this strong reducing effect has on the liver are significant. Reduced GSH L-glutathione levels have been found in patients suffering from HIV, hepatitis C and other liver diseases. Supplementation with GSH has been found to restore normal levels of glutathione to the liver, and it has been demonstrated that the treatment has improved such conditions significantly. Atherosclerosis is a condition of the arteries caused by the deposition of plaques formed from oxidized low-density lipoproteins, otherwise known as bad cholesterol. The strong antioxidant effect of GSH prevents this from LDLs from being oxidized and deposited on the arterial wall. There are other results of glutathione supplementation that indicate the effectiveness of antioxidants in the treatment of serious liver conditions, and there are no doubts that combating the effects of free radicals and oxidizing agents within the liver has a positive effect on many potentially serious liver diseases. Many of these are exacerbated by the generation of free radicals by relatively modern pollution sources such as pesticides, petrol and diesel emissions, tobacco fumes and various other chemical emissions. A strong antioxidant such as L-glutathione cannot be anything other than an effective means of reducing the biological effect of these oxidants. It protects not only the liver but also the lungs and cardiovascular system. For all these reasons a supplement consisting of L-glutathione or its constituent parts, glutamic acid, cysteine and glycine, provide significant protection against the stresses and strains of modern living. Increased pollution levels and heightened oxidative stress levels within the body are playing havoc with our body defenses, and GSH is an important one of them that can easily be enhanced by supplementation. There are no known reactions to L-glutathione supplementation, but pregnant women and babies should receive expert medical advice prior to taking it.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1996) Glycine
Date:
October 11, 2008 10:26 AM
The non-essential amino acid glycine is needed to generate muscle tissue and also for the conversion of blood glucose into energy. It is referred to as being ‘non-essential’ because the body can manufacture its own glycine, and is therefore not an essential component of your diet. Other uses to which glycine is put by the body includes the maintenance of a healthy nervous system, and is necessary for the proper functioning of the digestive system. Amino acids play three essential roles in the human body: 1. They are the building blocks of proteins: proteins comprise about half of the dry weight of the majority of your body cells, and without them there would be no life. They are produced using monomers known as amino acids, and there are about 20 different amino acids used to make the vast variety of proteins that make up the human body. Proteins are needed to form enzymes, the catalysts that permit the majority of chemical reactions within our bodies, and also genes, the building blocks of DNA. 2. More relevant here, amino acids play an important role in the production of ATP (adenosine triphosphate) from ADP (adenosine diphosphate) by phosphorylation with creatine phosphate. The more creatine phosphate available, the more ATP can be produced. Since ATP is the molecule responsible for the generation of energy, then the more ATP available the more energy is generated. Although creatine is available from many food sources, it is destroyed by cooking, and over half of what you use is made from the three amino acids, glycine, arginine and methionine. The energy produced in this way is very short-lived, and last only a few seconds - more on that later. 3. Glycine is heavily involved in the production of collagen, which is the substance that maintains the flexibility of your skin and other connective tissues while still maintaining their strength and firmness. Without glycine your skin would become slack due to the degrading effect of sunlight, free radicals and oxidation. The non essential amino acid, glycine, is believed to offer other benefits to the human body, but it is the second of those above, the production of ATP, which interests us here. ATP is an extremely important nanomolecule, second in importance to the body only to DNA, and possibly also RNA since the two are linked. RNA makes copies of your DNA structure for use in cell division and growth. When a cell expends energy for whatever reason, such as when I am typing this, or when your heart beats, or even when your liver synthesizes a protein, one of the phosphate groups is removed from the adenosine triphosphate molecule, and converts it to adenosine diphosphate (ADP). The ATP is then said to be 'spent', just as your energy is spent when you are tired and can exercise no more. The ADP is then immediately reconverted to ATP in the mitochondria, a part of every cell in your body. A cell can contain hundreds, or even thousands, of mitochondria, the number depending upon that particular cell's need for energy. Hence, cells in your muscles, or in your liver where most of the body's chemistry takes place, contain thousands of mitochondria whereas those in your scalp contain a lot less. Once changed to ATP, a phosphate is again lost when energy is expended, and so the cycle continues. Glucose is needed allow the ADP to be converted to ATP, hence the need for sugars, or the carbohydrates from which they are manufactured in your body. Each cell can contain up to a billion molecules of ATP, although the couch potatoes among you probably have a lot less! Your store of ATP molecules last about 2 to 5 seconds before being changed to ADP although more rapidly for athletes that expend a lot of energy. Then the energy stored in the form of glycogen in the liver kicks in for another 4 - 6 seconds. Additionally, you cannot expend more energy that the (eventual) sugars that you take in your diet, which can be in the form of ordinary 'sugar' (sucrose), fruit (fructose), glucose, carbohydrates that are metabolized into sugars, or any other member of the sugar family (e.g. lactose, maltose, etc.). Glycine is one of what are called glucogenic amino acids, which refers to their ability to provide glucose to the blood. Because it helps to maintain proper blood glucose levels, it is often prescribed for conditions that are caused by low glucose levels, such as hypoglycemia that shows symptoms of fatigue and tiredness, and also anemia and what is known as CFS (chronic fatigue syndrome). The one activity of the human body, in fact that of any mammal, for which ATP is essential, is the heartbeat. Without that no mammal could survive, or any other creature that relies on a circulation system for life. The only reason you heart has to beat is to pump your blood around your body, and it is your blood that contains the oxygen and nutrients needed to sustain life. Your cardiovascular health relies on lots of ATP being available to power each and every heartbeat. Analysis of the heart during the final stages of heart failure has revealed that there is a general decrease in the myocardial arginine: glycine amidinotraferase (AGAT) gene expression, which is indicative of the necessity of this enzyme for proper heart function. The enzyme is responsible for the first stage in the biosynthesis of creatine from glycine. Creatine is well known to athletes, and while it is available naturally from some food sources, it can be destroyed during cooking, and at least 50% of the creatine needed by the body is produced in the liver, pancreas and kidneys. It is creatine phosphate that is broken down into creatine and phosphate, the latter of which is used by the mitochondria to regenerate ATP from ADP.
The study carried out on the reduced AGAT levels found in heart failure patients indicates the importance of glycine to heart health. Without a good supply of glycine, there will insufficient creatine produced biochemically to generate the phosphate needed to for the ATP to produce the energy required to keep the heart pumping with the required strength. The energy provided by the mitochondria is used locally by the cells in which it is produced, and within a few seconds of that production. As explained earlier, ATP stores are used up within 2 - 5 seconds, and glycogen stores within another 4 - 6 seconds. That is why sprinters cannot keep running at maximum speed for more than around 10 seconds or so, because the immediate availability of glycine, and hence creatine, are insufficient to last longer than that. That is one reason why they have to finish those 100 meters as fast as possible, because otherwise they would run out of energy. Other than trying to win, of course! However, when it comes to the heart, ATP stores are essential, and the cells in your heart require a constant supply of ATP from creatine, which itself depends upon your intake or biosynthesis of glycine. Since dietary sources are insufficient to meet all your needs, and destroyed by cooking, a glycine supplement is the only way to ensure a sufficient intake. You cannot undernourish your heart and remain healthy.
ATP biosynthesis is essential if that of glycine theoretically is not, but the fact that 50% of your glycine requirement has to be produced by your body and the other 50% is sensitive to heat during cooking, a supplement of glycine could be essential to many people.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1912) Broken Cell Chlorella - Single Celled Micro alga
Date:
April 21, 2008 05:06 PM
Chlorella is what is known as a micro alga, a single celled vegetable organism that grows in fresh water. Microalgae are microscopic species of plant life that are likely responsible for the biological evolutionary history of our planet. Most people associate algae with seaweed: marine plant life. However, this is a restricted view since algae are also common on land, although are rarely conspicuous and still require an aqueous environment if not necessarily a salt water ocean. The reason for this is that algae have no vascular tissue to draw moisture up into the body of the plant as terrestrial plants do, and they tend to be found in tropical regions, on snow in areas of the Arctic and also on exposed areas of stone and rock in symbiosis with fungi in the form of lichens. They can also be found in freshwater ponds and rivers, and chlorella is one of these. Its scientific name is Chlorella pyrenoidosa, and it occurs worldwide. It is said to have the highest concentration of chlorophyll of any other known plant in addition to its other highly nutritional content. The superlatives are almost limitless for such a small plant that most of the general population is unaware of. It is the first plant known to have a true nucleus, it has been around for about two and half billion years, and it can multiply itself fourfold making it the fastest growing species of plant known on earth. It beats other fast-growing algae and bamboo out of site. So what of its nutritional content? It is believed by NASA to be the ultimate foodstuff for long-term travel in space and an ideal crop for colonizing communities. Were a space community to be established on Mars, chlorella would be the first to be cultivated under these big glass domes we all see in the movies! It is more than just a foodstuff though; it is also the most powerful known natural detoxifier for the human body, which makes it practically the ideal food. Why is this? If any food deserves to be referred to as a ‘superfood’ it is chlorella. It consists of over 60% bioavailable protein, and contains six members of the vitamin B complex (1, 2, 3, 5, 6, 12) and also vitamins A, C, E and K. It is therefore very high in antioxidants and excellent for destroying free radicals as soon as they are formed, and before they can cause problems such as atherosclerosis and excessive cell damage. It also contains more than its fair share of minerals such as calcium, manganese, magnesium, phosphorus and zinc, and also iodine, folic acid and a high proportion of iron. That is not all: it contains many more nutrients essential for a healthy life, but above all chlorella contains all eight essential amino acids. Human biochemistry and metabolism need 20 amino acids to function properly, twelve of which can be manufactured by the liver from these eight: leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine, and sometimes serine is added. These are called the essential amino acids from which all the others that your body needs can be manufactured. Amino acids are needed to build proteins and DNA, manufacture body cells, repair damaged tissue, help the immune system to protect you from invading bacteria and viruses, ensure that the oxygen you breathe gets to the cells where it is needed to sustain life and carry out many other functions besides. Without them you could not exist. Chlorella contains five times more protein and amino acids than eggs do. The Chlorella Growth Factor or CGF is a combination of these amino acids, together with nucleic acids, carbohydrates and peptides that have not yet been completely characterized. The CGF promotes the growth of body cells, and stimulates cell repair in a way not seen before in any other food. It has been shown to promote the growth of children in a natural and safe way. Not only this, but it has been found not to promote the growth of diseased or cancerous cells, only healthy ones. The fact that that this accelerated growth does not happen with adults indicates that the Chlorella Growth Factor supports the natural growing process, although in adults it has been seen to accelerate the repair of damaged body tissue. Chlorella also appears to strengthen the immune system, and researchers have found the presence of a polysaccharide in the cell walls of the microalgae that acts with CGF to produce an interferon that protects the helper cells that aid macrophages to destroy invading bacteria and viruses. It can help our resistance to influenza, choryza (common cold), fungi such as candida and many other forms of invasion by foreign agents into our bloodstream. The detox effect of chlorella is largely contained within its cell walls that can bind with persistent toxic substances such as DDT, and bind with heavy metals to safely remove them from the body. In fact it is the ideal anti-toxin for life in today’s environment, full of vehicle exhaust fumes, pesticides and other chemical emissions. It has been claimed to be able to remove mercury from the body, but this has not been established. Probably the only problem with the ingestion and the efficiency of the body to use Chlorella to its full extent is the strength of the cell walls. Chlorella has very strong cell walls, which could also account for the concentration of nutrients within them. the traditional method to overcome this was to mill them using small glass or ceramic beads to break the cell walls down, but the Japanese have come up with a more effective means. High frequency sound waves are used to break the cell walls down supersonically, a technique known as ‘cracking’, and once cracked the cells can release up to 65% of its nutrients, compared to the 50% of the milling method. The nutritional content of single celled microalgae such as chlorella is amazing, and if the was only one food that you were able to eat, then this would be it. There is no other known species of plant or animal life that provides the range of vitamins, minerals, proteins and amino acids that chlorella does, and it truly is the king of all superfoods.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1764) Supports Healthy Blood Pressure
Date:
April 18, 2008 03:59 PM
3 tablets contain: Suggested Use: 3 tablets mid-morning and 2 tabs mid-afternoon between meals on an empty stomach.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1763) L-Carnitine For Health And Wellness
Date:
April 16, 2008 03:25 PM
Research continues to mount evidence that l-carnitine can help boost energy and quality of life. Carnitine comes from the Latin word for flesh: caro or carnis. L-carnitine was discovered and isolated from meat in the early 1900s. At that time, scientists thought that l-carnitine played a role in muscle function; this was many years before technology would advance so that this theory could be proved. Today, we know that this amino acid is found mostly in tissue of the body that requires lots of energy such as the heart, skeletal muscles, and liver. L-carnitine is considered a non-essential amino acid since the body manufactures it from l-methionine and l-lysine. Depending on one’s diet, the body manufactures most of, not all, the l-carnitine it needs every day. There are circumstances where a rare genetic disease can cause the body to not manufacture its own l-carnitine resulting in a deficiency which can cause secondary diseases such as cirrhosis of the liver, chronic renal failure, diabetes, heart failure or Alzheimer’s disease. Some medications can cause a deficiency as well, check with your doctor about prescriptions. The primary energy source for the body is long-chain fatty acids. L-carnitine plays an essential role in energy production process. This amino acid transports long-chain fatty acids into the mitochondria, where it is used to produce energy for each cell in the body. l-carnitine then removes the “acyl” group by products out of the mitochondria as they accumulate. Both the transporting in and out of the cells mitochondria is vital for continued muscle function to occur. Researchers suggest that the limiting factor in high intensity exercise is from the availability of l-carnitine in the muscle tissue. Studies conducted with this amino acid suggest that athletes experience improved performance when supplementing with l-carnitine by reducing post exercise lactate acid levels and improving recovery from exercise stress. Some research suggests that l-carnitine can help chronic fatigue individuals by shuttling long-chain fatty acids into the mitochondria where the body manufactures energy. The bulk of this research was done on chronic fatigue patients who consumed 2 grams per day of l-carnitine. Additional research was performed on individuals over 100 years of age and the results were these individuals experiences increase physical endurance and improved cognitive activity. L-carnitine can help cardiovascular conditions including angina, congestive heart failure, and peripheral artery disease. Recent studies showed male fertility improvement when l-carnitine was consumed on a regular basis. Men participating had better sperm motility which increases the changes of one reaching an egg and improving the odds of fertilization. Research also demonstrated that 1 gram of this amino acid daily over three months can help one reduce weight by improving fat metabolism. This holds consistent with the findings that l-carnitine transports long-chain fatty acids (fat) into cellular mitochondria so it can be burned as energy. With a good diet and exercise plan, reports suggest that even more weight loss can be achieved.
Safety is of particular concern when adding extra supplements to one’s diet such as l-carnitine. Good news, l-carnitine is very safe at 1 – 3 grams each day, even higher doses are safe with no side effects. With the mounting evidence on the benefits of l-carnitine consumption, what is stopping you from adding l-carnitine today to your supplement diet to improve health and wellness?
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1758) Which Protein Is Best For You?
Date:
January 18, 2008 11:16 AM
If you are physically active and taking supplements but still cannot seem to get the energy back in your body and brain, then it’s time to look at how much and what kind of protein you are getting. Even though dieters have been using high-protein diets for years, many are unaware of how much protein they actually need and how critical it is to their overall health. Low-protein diets can be lacking greatly in a lot of essential nutrients such as zinc, iron, manganese, chromium, copper, and others. This deficiency can cause illness and fatigue. Protein deficiency leads to difficult recovery from exercise, feeling tired, frequent colds, poor hair or nails, and a cessation in menstrual period for women, which may sound pleasant but is potentially dangerous. People of all ages are not aware of how much their protein needs change as they increase exercise. As your activity increases, so does your protein needs. Protein is important in your body because every single cell in the body is made up of proteins. Protein is also essential for muscle building, producing red blood cells, the production of various enzymes and hormones, and good hair, nails, and skin. Our immune systems are almost all protein based, so providing our body with protein means that we can fight colds and other infections better. Proteins are also needed in our body to repair muscle damage that occurs during mild exercise. Protein is made from a chain of amino acids and our body cannot make some of these amino acids, which means that they need to be found in our diet. There are eight amino acids that our body cannot make and must be found in our diet every day. These include: isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. Although it is nice to know which amino acids are essential, it is even more important to know where you can find these amino acids because your muscles and body need them on a daily basis. Since proteins are constantly being broken down, it is necessary to get some every day. It is suggested that women aged 19 to 70 need 46 grams of protein per day, while men of the same age need 56 grams. Now that you know that protein is essential to your life, what kind of protein is actually needed? Even though protein can be found in a good diet by simply eating meat, nuts, eggs, and other foods, many of us with busy lives need a quick and convenient source of protein. At a health food store, your choices are soy, casein, whey, and egg. Although the classic protein source is whey protein, the problem is that even though it has a high amount of useable amino acids, some people don’t like it or have a hard time taking it. Other proteins like soy and casein don’t have the complete amino acid content that your body is looking for. With all the different forms of protein available one might wonder which is best? Egg white is the perfect protein source. Egg whites contain more than half the protein of an egg and are also rich in chlorine, niacin, potassium, magnesium, riboflavin, selenium, vitamin K, and sulfur. Additionally, egg whites have a high amount of protein but exclude the cholesterol and sodium found in the yolk. Egg white protein is considered almost perfect because human requirements for amino acids and the amino acids contained in eggs are almost identical. Eggs are also one of the well-tolerated proteins, as over 90 percent of the protein of eggs is digested into the individual amino acids that your body needs. Egg white protein is one of the few products on the market that taste good without the added artificial flavors, colors, or additives.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1695) L-Glutathione Can Eliminate Toxins in the Liver
Date:
December 07, 2007 11:54 AM
L-glutathione is the reduced form of glutathione, and is a tripeptide synthesized in the animal and plant tissues from glycine, cysteine and glutamate. Commonly known as GSH, it contains thiol groups that are maintained in a reduced state, and is a very powerful antioxidant, considered to be the key antioxidant and protective substance in the body. Glutathione can reduce any disulfide groups in the cytoplasm within the body of the cell, and ensures that the cytoplasm is a strongly reducing medium protecting against oxidation. It has a synergistic effect with other antioxidants to protect the body against free radicals and oxidizing agents that cause so much damage to the body through what is commonly referred to as ‘oxidative stress’. However, there is more to it than that and it attaches itself to toxic chemicals and drugs in the liver and renders them into a state suitable for elimination from the body. These toxic materials include poisonous pesticides, hydrogen sulfide, carbon monoxide, heavy metals such as mercury, cadmium and chromium and many other substances that we come into contact with due to present day pollution of our atmosphere and foodstuffs. Glutathione can also help protect the body from the effects of chemotherapy and evidence is suggesting possible links with the control of some cancers, diabetes, atherosclerosis and many other degenerative conditions caused by free radical attack and the effects of pollutants. The way that GSH acts in the cells is that the redox state of the glutathione-glutathione disulfide couple is critical to the health of the intercellular and intracellular fluid. GSH in the reduced state of glutathione reacts with an oxidative agent such as hydrogen peroxide to form the oxidized form, glutathione disulfide and water. It hence mops up oxidizers such as peroxides and free radicals within the cytoplasm of the body’s cells, and also in between the cells. The disulfide is then converted back to GSH by the combined action of the enzyme glutathione reductase and NADPH (the reducing agent nicotinamide adenine dinucleotide phosphate). The cycle then repeats so that two molecules of glutathione continue to reduce damaging oxidizing agents without themselves being consumed. In so doing, the NADPH becomes oxidized. A continuous supply of NADPH is needed to allow GSH to undergo these biochemical reactions, and up to 10% of our blood glucose is used by the pentose phosphate pathway by which NADPH is synthesized. Since this cycle consumes no glutathione, it would appear that a supplement is unnecessary. However, this is not the case since the molecule takes part in other reactions in the body, particularly in the elimination of toxic heavy metals from the body. Mercury is highly reactive with the thiol that GSH is, and so will bind to form a stable Hg-sulfydryl bond in the liver. This mercury-glutathione chelate is unable to bind to other proteins or gain access to the body cells, and is eventually harmlessly secreted. The same is true of many other heavy metals that are reactive with thiol’s. In this way the body is protected from the harmful effects of these heavy metals. However, it results in the loss of the glutathione, and the pollution of modern day living can take a heavy toll of the GSH content of our bodies. For this reason a glutathione supplement is recommended, especially for city dwellers that may be exposed to more heavy metals than those residing in rural areas. However, the form in which this supplement is taken is very important, because the human digestive tract contains a significant amount of gamma-glutamyltranspeptidase. That is an enzyme which apparently destroys glutathione before it can be absorbed. However, it can be absorbed directly into the bloodstream by dissolving the pill between the teeth and inner cheek. It has also been suggestion that the supplement could be administered by injection. Others have suggested that rather than administer a supplement, individuals could take other supplements that contain the materials needed to stimulate the formation of GSH. Substances such as vitamin C, selenium (important in GSH biochemistry), methionine, alpha-lipoic acid and glutamine could all help to increase the body’s production of glutathione. A supplement of the constituent parts of cysteine, glycine and glutamic acid should also help. The dosage ranges recommended vary widely from 50mg to 500mg daily, and the effects of supplementation are not yet well know. Some specific conditions that this wonder antioxidant is useful in treating include liver disease such as hepatitis, cirrhosis and so on. Patients suffering from these diseases show a massive reduction in their GSH content and prior GSH treatment appeared to offer a significant degree of protection in controlled clinical investigations. Patients suffering from chronic hepatitis C have been found to be associated with reduced GSH levels, particularly if also HIV positive. Similar deficiencies have been noted in some lung conditions such as asthma and other pulmonary conditions. In such cases it has been demonstrated that administration of GSH supplements sufficient to restore normal levels of the substance improved the patients’ conditions by a significant amount. Its effect on atherosclerosis appears to be significant since a decreased level of GSH peroxidase has been recorded in such patients in addition to an increase in lipid peroxides, indicating that oxidation of the arterial wall had been occurring. Anti-viral therapies that rely on GSH biochemistry for their action have been found to be less effective in those with low GSH levels, and other studies have confirmed that supplementing with GSH improves the response to interferon treatment. These results indicate the activity of oxidizing agents and free radicals in liver conditions, and in fact this has been demonstrated by tests carried out in New York and Philadelphia in the 1990s. This suggests that the liver is prone to damage by oxidative stress, and that GSH levels may be able to be used as an indication of potential liver disease. What is evident is that a strong case can be made for glutathione supplementation as protection against potential liver, pulmonary and cardiovascular diseases, especially by those exposed to specific polluting agents such as primary or secondary tobacco smoke, auto and diesel fumes and chemicals and pesticides. L-glutathione is useful, not only for the elimination of toxins in the liver, but also in protecting this large and vital organ from the oxidative stress that modern living brings. L-Glutathione and its precursors are sold over the counter at your local or internet health food store.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1649) Protein And Its Role In Bodily Functions
Date:
November 09, 2007 05:00 PM
Protein is an essential organic compound composed of 20 or more amino acids which are joined by peptide bonds. Proteins serve as structural material such as connective tissue, and hair (i.e. collagen and keratin) can function as enzymes and hormones, as transporters of essential substances such as oxygen, antibodies, or regulators of gene expression. The importance of protein cannot be overstated in its effects on overall health regardless of age. Dieters using the low-protein diet can be seriously lacking in many essential nutrients including minerals such as zinc, iron, manganese, chromium, copper, etc. These deficiencies can lead to chronic illness, fatigue and make mental function more difficult. In order to fight sickness and disease, our immune systems need to be in optimum performance. Something you may not have realized but our immune system are almost all protein based. Providing the body with the correct proteins is like providing the proper building blocks of the immune system and can help to fight the common cold and infections better. Proteins are also used to repair muscles during exercise. There are eight essential amino acids which the body cannot manufacture and which we must derived from our diet each day. The essential amino acids are (i) isoleucine, (ii) leucine, (iii) lysine, (iv) methionine, (v) phenylalanine, (vi) theronine, (vii) tryptophan, and (viii) valine. With this list of proteins it is possible to determine where we can find these amino acids and incorporate them into our diet. We need protein in our diet on a daily basis, especially for muscle function which requires a particular mix of amino acids which are not found in many food sources. For example, to increase muscle mass, you need glutamine, carnitine, taurine, and arginine amino acids. Now that we know we need protein daily in our diet and that protein is essential to life. So the next question you may have is what kind of proteins are the best? Quality proteins found in your local grocery store can be found in meat, nuts, eggs, and other foods. If you turn to your local health food store, look at soy, casein, whey and egg proteins. The type of protein you take will depend upon what you are capable of eating, i.e. taste. Some people have trouble eating whey protein, while others cannot pallet egg protein.
The best protein found in nature however is derived from egg whites. Egg proteins are not only complete in its supply of what the body needs, the egg is rich in chlorine, niacin, potassium, magnesium, riboflavin, selenium, vitamin K, sulphur, and omega-3. An added bonus to eating egg whites is the lack of cholesterol and sodium in the yoke. Eggs are also one of the most tolerable proteins in the human body where over 90 percent of the proteins derived from eggs is digested into the individual amino acids our bodies need. By eating egg derived protein you are essentially supplying the body with the raw materials it needs for proper function. So, if you have been troubled by fatigue, poor hair and nails the answer may be to increase your protein intake or try an all natural egg white protein for three to four weeks and see what a difference it will make in your health and appearance
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1623) Increase Absorption Of Your Discount Vitamins With Bioperine
Date:
November 02, 2007 04:54 PM
In order to understand how you increase absorption of your discount vitamins with Bioperine, it is necessary to understand the metabolic process of thermogenesis. First, however, let’s have a look at what Bioperine is and where it comes from. Bioperine is obtained from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) of which it is a patented standardized extract. These peppers contain the alkaloid piperine, and the extract contains 95% piperine. The plants are grown in the ideal damp soil in regions of Southern India where the earth is rich in nutrients. The barriers are harvested just before ripening, and then dried in the hot sun before the extraction process is started. Piperine has many uses from flavoring to fly killer, but people have been using it for centuries to heal wounds though this is apparently unconnected with the use to which the extract is put. It has recently been found to help increase the absorption of a number of discount vitamins and minerals, including Vitamin B, beta-carotene, and selenium, by increasing the thermogenic activity of the body. Thermogenesis is one of the metabolic processes of the body that takes place within our cells whereby glucose is converted to energy, but at an accelerated metabolic rate. It is the rise in the metabolic rate that is referred to as thermogenesis. When you eat food, or take supplements, the metabolism increases above the normal rate, the amount of increase depending upon the type on nutrient taken. Fats will increase your metabolism at a lower rate than proteins will, for example, since more energy is needed to break down proteins than for fats. Another substance that stimulates thermogenesis is piperine. It does so by utilizing the biochemistry of the body so that the chemicals needed for thermogenesis are made available. Piperine triggers the release of compounds known as catecholamines, hormones that in turn stimulate the thermogenetic process. However, this occurs over a short period of time, so the nutrients that are needed should be present in the gut as well since the window of absorption is very narrow. The substance also modifies the epithelial cell wall of the intestine to make it easier for the nutrients to be absorbed into the bloodstream, and it also gives amino acids a kick to get moving to the cells in which they are required. Bioperine, then, not only sets off the metabolic changes that demand vitamins and other nutrients and enzymes, but also improves the conditions in your intestines so that these nutrients can more easily get to where they are needed. Basically, what Bioperine does is to cause the intestinal wall to become more permeable to nutrients, so that vitamins and drugs are not degraded when passing through the intestinal wall to the bloodstream. This improves digestion and absorption of minerals and vitamins, in addition to protein supplements frequently used in weight loss diets. Bioperine starts by generating a need for nutrition and then increase the bioavailability of the nutrients provided to meet that need. However, due to the short window of absorption that piperine generates, the vitamins and minerals you want absorbed should be co-administered with the Bioperine so that they are in place ready to be absorbed at exactly the right time. There have been several studies carried on the efficiency with which piperine achieves this. The absorption of three different types of nutrients has been measured with and without Bioperine. These were beta-carotene, a fat soluble vitamin, vitamin B-6, a water soluble vitamin, and also a mineral, selenium which was provided as selenomethionine. The absorption of these by the digestive system was measured by detecting them before and after in the blood, and were found to increase considerably when taken along with Bioperine, but not so with the control group without it. Measured increases were a 60% increase in beta-carotene, similar to that of vitamin B-6, and was 30% in selenium. The tests used a 5 mg dose of the Bioperine. Other studies have indicated an increase in the absorption of Coenzyme Q-10 of between 30% - 200%. This is the only piperine based product that has been patented for its effect in increasing the absorption of nutrients into the body, and also the only piperine based product to undergo such tests in the U.S. to substantiate its claims and prove its safety for use. The black pepper itself is a common household spice, and has been used in India for its medicinal properties for centuries. It is mentioned in the practice of Ayurveda and its concentration on the function of the digestive tract in human health. Many of its formulas contain black pepper amongst their ingredients. The bioavailability of nutrients is a significant factor in the health of any specific population, and the exponents of Ayurveda overcame this problem, by chance or design, six millennia ago. It has been demonstrated time and time again that diet is not the factor of importance in nutrition, but how much of that diet is absorbed through the intestines. This is yet another example of the medicines of our ancestors being shown to have a solid scientific basis, and perhaps we should pay more attention to those others that are disregarded by modern science. It could be that we have only scratched the surface of understanding human metabolism and biochemistry, and that there is much left to learn. Ancient wisdom should never be disregarded. Bioperine is also available in many supplement mixtures so that it is taken at the same time as the relevant vitamins and minerals. The recommended dosage is from 1 mg – 5 mg from 2 – 3 times daily. It takes around 2 – 5 mg of Bioperine to provide sufficient enhancement of absorption of the nutrients that are taken with it. Keep in mind that the nutrients are best taken at the same time, and that taking the extract itself will simple increase the absorption of any nutrients that are in the intestine at that time. Bioperine can be purchased at your local or internet vitamin store.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1615) Learn about Bone Health!
Date:
April 20, 2007 12:43 PM
Bone Health Approximately 44 million American women and men aged 50 and older have osteoporosis (severe bone loss) or osteopenia (mild bone loss), with women being affected about twice as often as men. At least 1.5 million fractures of the hip, vertebra (back or neck), or wrist occur each year in the United States as a result of osteoporosis, and the annual cost of treating this disorder is nearly $14 billion and rising. Unfortunately, the toll in human suffering and loss of independence is even greater. In this issue of Ask the Doctor, we will discuss the risk factors for osteoporosis and some key nutrients you can add to your diet that can minimize bone loss and reduce your chances of developing this disease. Q. What are the risk factors for osteoporosis? A. Small body frame, underweight, Caucasian or Asian race, a sedentary lifestyle, cigarette smoking, excessive alcohol or caffeine intake, high intake of carbonated beverages (especially colas), and having other family members with osteoporosis all increase personal risk of developing the disease. Certain medical conditions, including diabetes, celiac disease, hyperthyroidism, rheumatoid arthritis, chronic obstructive lung disease, hyperadrenalism, and hyperparathyroidism, are all associated with an increased risk of osteoporosis. Some medications increase the rate at which bone is lost; these include drugs prescribed for the treatment of seizures, drugs used for blood thinning, steroids such as prednisone, aluminum-containing antacids, and loop diuretics (furosemide {Lasix}). Q. Isn’t bone loss just a normal consequence of aging? A. Although bone mass normally declines after the age of 35, bone loss severe enough to cause fractures after just minor trauma (such as bump or fall) seems to be a relatively new phenomenon. Osteoporosis was rare in the late 19th century, and it was not until around 1920 that the condition began to attract attention among doctors. Since that time, the percentage of people who develop osteoporosis has continued to increase. For example, the age-adjusted prevalence of osteoporosis in Q. Can osteoporosis be prevented? A. Engaging in regular weight bearing exercise, avoiding excessive consumption of alcohol and caffeine, and quitting smoking will slow the rate of bone loss. Eating adequate, but not excessive, amounts of protein also enhances bone health. In addition, a growing body of research has shown that supplementing with various vitamins and minerals may not only help prevent, but in some cases actually reverse, bone loss. At least 15 different nutrients have been found to play a role in bone health. Q. What type of calcium is best? A. For most people, calcium salts are absorbed about the same, between 30% and 40% of the administered dose. People who low stomach acid (hypochlorhydria) should not use calcium carbonate, because that form of calcium is absorbed poorly in the absence of stomach acid. Calcium phosphate may be preferable for many older people, because phosphorus is necessary for normal bone formation, the phosphorus intake of older people is often low, and calcium supplements inhibit the absorption of phosphorus. Also, calcium bound to phosphorus is the form in which calcium in the bone is stored, and it has a much greater bone activity than other forms. Q. How much vitamin D is needed to promote strong bones? A. Because vitamin D is produced when the ultraviolet rays from the sun hit skin, people who stay out of the sun, wear sunscreen, or live in a northern latitude (such as Boston or Seattle) where less ultraviolet light reaches the skin, are at increased risk of vitamin D deficiency. In addition, aging decreases a person’s ability to synthesize vitamin D in the skin. Results from five research trials on vitamin D found that supplementation with 700-800 IU of vitamin D per day decreased the number of hip fractures by 26%, but 400 IU per day was ineffective. In addition to enhancing bone health, vitamin D improves nerve and muscle function in older people, thereby reducing their chances of falling down. Supplementation of elderly women with 800 IU of vitamin D per day has been shown to decrease the number of falls by about 50%. Q. Is that much vitamin D safe? A. The Food and Nutrition Board of the Q. Why would nutrients besides calcium and vitamin D is important? A. Bone is living tissue, constantly remodeling itself and engaging in numerous biological functions. Like other tissues in the body, bone has a wide range of nutritional needs. The typical refined and processed American diet has been depleted of many different vitamins and minerals, some of which play a key role in promoting bone health. Not getting enough of one or more of these micronutrients may be and important contributing factor to the modern epidemic of osteoporosis. In addition, supplementing with calcium may cause a loss of magnesium, zinc, silicon, manganese, and phosphorus, unless these nutrients are also provided. Q. What nutrients besides calcium and vitamin D promote healthy bones? A. Magnesium, zinc, copper, manganese, vitamin K, boron, strontium, silicon, folic acid, vitamin B6, vitamin B12, phosphorus, and vitamin C have all been shown to play a role in bone health. Following is a brief description of the role that each of these 15 nutrients play in building healthy bones. Calcium: A component of the mineral crystals that make up bone. Vitamin D: Enhances calcium absorption, prevents falls by improving nerve and muscle function. Magnesium: Important for bone mineralization (accumulation of minerals which form bones). Magnesium deficiency is associated with abnormal bone mineral crystals in humans. In an open clinical trial, magnesium supplementation increased bone mineral density by an average 5% after 1-2 years in postmenopausal women. Copper: Laboratory research has found that copper promotes bone mineralization and decreases bone loss, and that osteoporosis can develop if the diet is deficient in copper. Western diets often contain less copper than the amount recommended by the National Academy of Sciences. In a 2-year double-blind trail, copper supplementation reduced bone loss by 90% in middle-aged women, compared with a placebo. Zinc: Like magnesium, zinc is important for bone mineralization, and also has been shown to decrease bone loss. Low dietary zinc intake was associated with increased fracture risk in a study of middle-aged and elderly men. The zinc content of the diet is frequently low; a study of elderly low-income people found they were consuming only half the Recommended Dietary Allowance for this mineral. Manganese: Plays a role in the creation of the connective-tissue components of bone. Manganese deficiency in laboratory tests resulted in low bone mineral density and weak bones. Manganese deficiency may be associated with the development of osteoporosis. Boron: Supports creation of bone-protecting hormones such as estrogen, testosterone, and DHEA. Boron supplementation prevented bone loss in experimental studies. In human volunteers consuming a low-boron diet, boron supplementation decreased urinary calcium excretion by 25-33%, a change that may indicate reduced bone loss. Silicon: Plays a role in the synthesis of the connective-tissue components of bone. Silicon deficiency has been associated with bone abnormalities. In an observational study, higher dietary silicon intake correlated with higher bone mineral density. In a clinical trial, administration of an organic silicon compound increased bone mineral density of the femur (or thigh bone) in postmenopausal women. B vitamins (folic acid, vitamin B6, and vitamin B12): These three B vitamins have been shown to lower blood levels of homocysteine, a breakdown product of the amino acid methionine. An elevated homocysteine concentration is a strong and independent risk factor for fractures in older men and women. Homocysteine levels increase around the time of menopause, which may explain in part why bone loss accelerates at that time. In a 2-year double-blind trial, supplementation of elderly stroke patients with folic acid and vitamin B12 reduced the number of hip fractures by 78%, compared with a placebo. Strontium: This trace mineral is incorporated into bone and appears to increase bone strength. It also stimulates bone formation and inhibits bone breakdown. Controlled trials have demonstrated that strontium supplementation of postmenopausal women increases bone mineral density and decreases fracture risk. Vitamin K: Best known for its effect on blood clotting, vitamin K is also required for the creation of osteocalcin, a unique protein found in bone that participates in the mineralization process. The amount of vitamin K needed for optimal bone health appears to be greater than the amount needed to prevent bleeding. Vitamin K levels tend to be low in people with osteoporosis. In randomized clinical trials, supplementation of postmenopausal women with vitamin K prevented bone loss and reduced the incidence of fractures. Q. Which form of vitamin K is best? A. Two forms of vitamin K compounds are present in food: vitamin K1 and vitamin K2. Vitamin K1 (also called phylloquinone) is present in leafy green vegetables and some vegetable oils, and vitamin K2 is found in much smaller amounts in meat, cheese, eggs, and natto (fermented soybeans). To make things a little more complicated, Vitamin K2 itself can occur in more than one form. The two most important to this discussion are menaquinine-4 (MK-4, also called menatetrenone), which is licensed as a prescription drug in Research suggests that MK-7 from natto may be an ideal form of vitamin K. The biological activity of MK-7 in laboratory studies was 17 times higher than that of vitamin K1 and 130 times higher than that of MK-4. After oral administration, MK-7 was better absorbed and persisted in the body longer, compared with MK-4 and vitamin K1. Although both have shown ability to prevent osteoporosis in laboratory research, a much lower dosage (600 times lower) of MK-7 is required, compared to MK-4, to obtain beneficial effects. Thus, MK-7 has greater biological activity, greater bioavailability, and possibly more potent effects on bone, compared with other forms of vitamin K. The potential value of MK-7 for bone health is supported by an observational study from Q. Why is strontium so important in building strong bones? A. Strontium is of great interest to bone health researchers and has been studied in very high doses. Surprisingly, lower doses are not only safer for long-term supplementation, but may in fact have a greater impact on bone health than very high doses. Too little, and bone density is impaired; too much and health may be impaired. This is a case where dosing needs to be just right for optimal impact. Therefore, until more is known, it is wise to keep supplemental strontium at less than 6 mg per day. Q. Can people taking osteoporosis medications also take bone-building nutrients? A. Because nutrients work by a different mechanism than osteoporosis drugs, nutritional supplements are likely to enhance the beneficial effect of these medications. Calcium or other minerals may interfere with the absorption of biphophonates such as alendronate (Fosamax) or etidronate (Didronel). For that reason, calcium and other minerals should be taken at least two hours before or two hours after these medications. Also, it is always best to discuss the supplements you are using with your healthcare practitioner to create an integrated health plan. Final thoughts… Bone health ramifications extend beyond osteoporosis and fractures. Bone health is essential for freedom of movement, safety, comfort, independence and longevity. Weak bones do not heal well – sometimes they never heal at all. Osteoporosis-related fractures rob us of our mobility and consign thousands of Americans to walkers and wheelchairs every year. In fact, 40% of people are unable to walk independently after a hip fracture, and 60% still require assistance a year later. The most terrible consequence of fractures related to osteoporosis is mortality. The impairment of the ability to move around freely can cause pneumonia and skin damage leading to serious infections. It is estimated that suffering a hip fracture increases the risk of dying almost 25%. Making bone health a priority now will allow you to reap health dividends for many years to come.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1523) Supplements good for reducing stress and boosting energy!
Date:
March 26, 2007 02:05 PM
Vitality 101
More and more Americans are feeling overworked, overtired, and overcome by life’s demands. We just do not have the energy we need to meet our responsibilities to the people we care about. More importantly, we don’t even have the energy to have fun! It seems that a constant feeling of fatigue has become part of the American way of life.
Research has shown that the same processes that cause lack of energy can rob us of sleep, saddle us with excess weight, disrupt our hormonal balance, and create significant amounts of stress in our daily lives. Chronic stress can dramatically contribute to fatigue, sleep disorders, irritability, and anxiety. The research simply confirms what most of us already know – uncomfortable stress can really wear us out mentally and physically! It can take away the satisfaction of a job well done. It can take away our ability to believe in ourselves. And, sadly and maybe most importantly, continual stress can take the fun and joy out of life.
In a separate issue of Ask the Doctor, we discuss the energy and sleeping needs of people suffering from chronic fatigue syndrome and fibromyalgia. In this issue, I discuss the 3-step process I call “Vitality 101.” People do not have to accept pain, insomnia, or fatigue. It’s time for everyone to feel great and have a life they love!
Step 1 – Nutrition
Good overall nutrition is important for everyone! As a foundation product to support energy levels, a powdered drink mix is a pleasant, easy way to ensure that you are taking all of the necessary vitamins, minerals, and amino acids that you need to have great energy all through your day.
The following chart lists the most critical ingredients. You can see that almost all of the vitamins and minerals work together to help improve energy levels and overall health.
In addition to the powdered energy drink mix, it is important that you also take a high potency vitamin B-complex supplement. This should include niacinamide, thiamin, riboflavin, vitamin B6, vitamin B12, pantothenic acid, and choline, which are especially important to restore the energy production needs of your body. It is also critical to get enough water, as most Americans are chronically dehydrated.
Step 2 – Rest Your Body
Having trouble sleeping is one of the most troubling symptoms of stress. While the stress is wearing us down and making us tired, it’s also keeping us tense and unable tot relax. The result? That easy drift into sleep becomes harder and harder. And if we are lucky enough to actually get some shut-eye, stress will often wake us up, sometimes several times a night.
This occurs because excess stress suppresses the sleep center in the brain. It is important to break the “stress/insomnia cycle” early, before it results in pain and hormonal and immune dysfunction!
Because good quality sleep is how the body repairs and re-energizes itself, it may be helpful to use herbal products to promote good quality sleep. There are many natural supplements that are marketed as sleep formulas. To get the best results, it is very important that the right ingredients are in the sleep formula you buy. Look for a supplement that has a blend of herbs that promote deep sleep, such as valerian, L-theanine, hops, passionflower,
Step 3 – Manage Excess Stress Levels
In this fast paced world, it is important to learn to manage the stressor in our lives. Glandular extracts, such as raw adrenal extract, can offer natural support to help our bodies deal with the effects of stress and, in turn, can boost your energy levels. Exercise is another stress buster. Using your body physically is important for good health. Find something that is fun for you, however, or you are unlikely to stick with it!
Q. Does stress zap my energy in any other ways besides making me lay awake at night and causing me to be a zombie the next morning?
A. Most people are familiar with the body’s dramatic response to an emergency. The heart pounds, the muscles constrict, and the lungs expand – and while this is happening, we are capable of greater than normal strength and speed. This response is the body’s way of rescuing itself when faced with an emergency. We don’t have to think about it to make it happen. It’s automatic.
The same can be said of a chronic stress response. Whether we’re late for a business meeting because we’re stuck in traffic, or worrying about how we are going to pay for our children’s college tuition, our response to stress happens automatically. The difference between the two is that the body’s response in an emergency starts and resolves itself quickly. The response to being stuck in traffic may not.
The body makes the “stress hormone”, cortisol, to handle the normal stresses of day-to-day living. But in an emergency situation, the adrenal glands, located above the kidneys, secrete increased amounts of this hormone until the emergency passes. Then the body returns to its normal function. Unfortunately, however, chronic stress is more complex. When our body is subjected to increased amounts of the hormone, cortisol, for an extended time, it can lead to a condition known as “adrenal burnout” or “adrenal fatigue.” While it’s true that very large amounts of cortisol can have damaging effects on our hormones, too little cortisol doesn’t allow us to respond to stress properly. It’s really a matter of balance.
Q. How can I control the stress in my life and re-energize?
A. Many people who are under constant stress may have adrenal burnout. Adrenal burnout occurs when the adrenal glands are constantly producing cortisol in response to chronic stress. Over time, this exhausts the adrenal reserve, meaning the adrenal gland can no longer increase cortisol production in response to stress.
The good news is that changes in our hormone levels can return to normal when stress is decreased. The key in learning how to deal with daily stress is to allow the body to return to its normal state. I discuss additional techniques for coping with stress in my recent book Three Steps to Happiness! Healing Through Joy (see my website, www. jacobeitelbaum .com, for more information). In addition to stress control, it is important to supplement your adrenals with a glandular therapy regimen to ensure healthy cortisol levels and adrenal function. Glandular therapy, which uses the concentrated forms of bovine (cow) or porcine (pig) glands, can improve the health of our glands. Pioneers in the field of endocrinology (the study of hormones) hypothesized that glandular extracts work by providing nutrients the body lacked and thus repaired the malfunctioning gland.
Adrenal Extract
If you are one of the unlucky folks with stressed-out adrenal glands, you should see great results from taking raw adrenal supplements. Be sure to buy adrenal extract supplement that contains both whole adrenal and cortex adrenal.
The best adrenal supplement should also contain vitamin C, vitamin B6, pantothenic acid and licorice. Licorice contains glycyrrhizin, which is broken down into glycyrrhizic or glycyrrhetinic acid. This compound inhibits the activity of an enzyme that turns active cortisol into inactive cortisol. While in high amounts (greater than 100 mg of glycyrrhizic acid/day), licorice administration causes hypertension, no such effects have been observed at lower doses. Experts have speculated that inhibition of the cortisol-converting enzyme may reduce cortisol-related symptoms associated with adrenal insufficiency. The adrenal glands use these nutrients to manufacture cortisone and other compounds. It just makes sense to purchase an adrenal supplement with these supportive ingredients.
Liver Extract
Did your grandmother ever tell you to eat your liver so that you didn’t get “tired blood?” Well, it turns out that she was right. Liver extract is another glandular extract that can help improve energy levels.
Liver extract is an excellent source of highly bioavailable nutrients including iron, B vitamins (especially B12), and other minerals. The stamina and energy-enhancing benefits of liver are widely touted. Liver extract has been shown to support healthy function of the liver and increase the energy levels inside our body.
Because heat will destroy the key components in the liver, a high quality liver extract supplement should be cold-processed and encapsulated to enhance speed and absorption of nutrients from liver. A high quality aqueous liver extract supplement should also contain vitamin B12 to support healthy blood iron and oxygen levels to energize.
Q. It will be great to get a good night’s sleep. Are there also any other natural alternatives that could help promote relaxation and increase my energy levels during the day?
A. Yes, there are. Rhodiola rosea is an all-natural herb that has long been used to help relieve stress and increase energy. Rhodiola has also been used to lift our moods, improve sexual satisfaction, and even help in certain nervous system disorders. First used in Siberia and
In clinical trials, the most effective Rhodiola rosea extract was found to contain 3% rosavins and 1% salidroside. While there are many Rhodiola supplements in health food stores, only those containing these specific amounts can provide the best results.
Lifestyle Treatments
Altered digestion, food intolerances, decreased energy, fatigue, cognitive problems, and sleeplessness create the need for changes in daily living routines. These can include alterations in diet; exercise modifications; alterations in activities of daily living according to one’s energy level; and sleep/rest management. All may require the assistance of a professional clinician, such as a chiropractor, nutrition specialist, physical and/or occupational therapist, mental health professional, or sleep therapist.
Conclusion
Super busy lives demand super strength nutrition. Begin each day with a powdered nutritional supplement after getting at least 8 hours of sleep each night. In addition to the nutritional beverage mix, a vitamin B complex supplement should be taken every morning. The nutritional drink mix and the vitamin B complex supplement will ensure that your body has all the vitamins, minerals, amino acids, and other nutrients to combat your fatigue. Taking a daily adrenal supplement, like the one discussed earlier, will provide the much needed (and often depleted) nutrients your body may be lacking, and help you recover lost energy. Rhodiola rosea, and ginseng can offer additional natural nutritional support in your busy life to boost your energy levels. These nutritional supplements can be used daily and you will feel energized to get through each day’s challenges and opportunities!
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1496) Revita
Date:
March 08, 2007 12:27 PM
Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product. Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class. To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules. Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth. Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available. Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects. In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls." In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded: • The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls. • 78.9% of subjects showed an increased mean value of hair diameter. • "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness." Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results. Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings: • Total Number of Hairs: Significantly Increased • Total Number of Terminal Hairs: Significantly Greater • Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher • Hair Follicle Activation: Intensive In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials. Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss. Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area. The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp. Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles. Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E. Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth. Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing. Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial. If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months. Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study. The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo. Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion. After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier. Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss. MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM. The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes. MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications. Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness. The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone. According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss. The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study. Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate. Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate. The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased. Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft. Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids. Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth. L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications. The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth. Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day. In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing. Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic. Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth. Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle. Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss. After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week. This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted. Q. Is Revita safe ? A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe. Q: Can I use hair sprays, mousses, gels, etc.? A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita. Q: Can I have my hair colored or permed while using Revita ? A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita. Q: What is SLS/SLES free ? A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health. Q: Can I blow dry my hair after using Revita ? A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita. Q: Who is a candidate for Revita ? A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately. Q: What type of results should I expect with Revita ? A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment. Q. Does Revita have any systemic side effects ? A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically. Q. Does Revita work for women? A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair. Q. I am using other topical treatments. Can I use Revita at the same time ? A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair. Q. Do I need to use Revita for a long time ? A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp. Q: Is stress a factor in hair loss? A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1480) Chronic Fatigue Syndrome and Fibromyalgia
Date:
February 28, 2007 12:02 PM
This is a fast paced world. We are all busy; living our full lives, burning the candle at both ends. We all get tired. We all get sick from time to time and maybe even depressed. But the illness called chronic fatigue syndrome is not like the normal ups and downs that we experience in everyday life. People with chronic fatigue syndrome feel overwhelming fatigue, and often pain as well. This is an illness that does not go away with a few good nights’ sleep. It drags on and on and doesn’t resolve itself. It steals vigor and energy over months, and sometimes even years. In this issue of Ask the Doctor, we will talk about powerful vitamins, minerals, amino acids, and herbs combined in scientifically validated formulas that people with chronic fatigue syndrome or fibromyalgia can use every day. These nutrients help address some root problems of chronic fatigue syndrome and fibromyalgia by restoring energy and health to sufferers. Q. What is chronic fatigue syndrome? A. Chronic fatigue syndrome (CFS) also known as chronic fatigue and immune dysfunction syndrome (CFIDS), or myalgic encephalomyelitis (ME), is a group of symptoms associated with unrelenting and debilitating fatigue. The profound weakness of CFS causes a persistent and substantial reduction in activity level. You feel too tired to do normal activities or are easily exhausted for no apparent reason. Besides extreme fatigue, symptoms of CFS include general pain, mental fogginess, flu-like symptoms, and gastrointestinal problems. A list of symptoms includes:
The number of symptoms and the severity of these symptoms can vary among people. The symptoms of CFS hand on or reoccur frequently for more than six months. Q. Are chronic fatigue syndrome and fibromyalgia considered being the same illness? A. Fibromyalgia syndrome (FMS) is a painful shortening of muscles throughout the body. FMS is basically a sleep disorder characterized by many tender knots in the muscles. These tender knots, called tender or trigger points, are a major cause of the achiness that people with fibromyalgia and CFS feel. Approximately 80 percent of chronic fatigue syndrome patients have received and overlapping diagnosis of fibromyalgia syndrome. For most people, fibromyalgia and chronic fatigue syndrome are the same illness. Q. What causes chronic fatigue syndrome? A. There are many causes that can trigger CFS. Current research is looking at the roles of neuroendocrine dysfunction, viruses, environmental toxins, genetic predisposition, food sensitivities, yeast overgrowth, faulty digestion, or a combination of these factors. For many people, CFS is triggered by a bout with a viral illness (like a cold or the flu), or even a stressful event. CFS is usually a mix of underlying causes. It is like a domino effect in that each problem can trigger another problem, and so on. For example, fatigue and poor sleep can trigger a weakened immune system, which can, in turn, trigger yeast or bacterial infections. Q. Who gets chronic fatigue syndrome? A. CFS is more common than you might expect. It strikes people of all ages, racial, ethnic, and socioeconomic groups. Approximately 800,000 people nationwide have CFS and over six million have fibromyalgia at any given time. It is important to stress that CFS is a real illness; it is not “just in your head.” Unfortunately, sufferers of CFS may find that many healthcare practitioners discount the symptoms of this illness or misdiagnose it as another disease. This can lead to additional emotional suffering. Q. How long does chronic fatigue syndrome last? A. The illness varies greatly in its duration. Some people recover after a year or two. More often, those who recover are more likely to do so three to five years after onset. Yet for some people, the illness seems to simply persist. There are rare cases of spontaneous improvement after five years without undergoing any treatment. However, this is very unusual. Q. What are the complications of chronic fatigue syndrome? A. The patterns of CFS vary from individual to individual. However, many common patterns of symptoms are seen in CFS sufferers. These symptoms and problems interact and create new symptoms and problems. For example, infections and disrupted sleep can lead to digestive, hormone, and immune problems. Infections The most notorious pattern seen in CFS is the one in which a person suddenly comes down with a flu-like illness that doesn’t go away. These viral or bacterial infections can suppress the body’s master gland, the hypothalamus. Since the hypothalamus controls the other glands, including the adrenals, ovaries, testes, and thyroid, suppression of this gland will lead to a subtle but debilitating decrease in the functioning of all glands and their hormones. Suppressed hypothalamic function from chronic infections can then trigger sleep dysfunction. Disrupted Sleep The suppression of the hypothalamus gland can lead to poor sleep because the body confuses its day/night cycles. Because of this, people with CFS have trouble staying in the deep, restorative stages of sleep that “recharge their batteries.” Poor sleep can cause immune suppression, which may lead to secondary bowel infections. The bowel infections seen in people with CFS can cause decreased absorption of nutrients, which can lead to chronic vitamin and mineral deficiencies. Q. Is there a cure for chronic fatigue syndrome? A. Treating chronic fatigue syndrome presents a significant challenge to people with CFS and their healthcare practitioners. Recently, a published placebo-controlled study ( of which I was the lead investigator) showed that when using an integrated treatment approach, over 85 percent of CFS and fibromyalgia patients can improve, often dramatically. The full text of this study can be seen at ‘www.endfatigue.com’. An editorial in the April 2002 issue of the Journal of the American Academy of Pain Management noted that this treatment, which I developed, is now a highly effective and excellent part of the standard of practice for treatment of fibromyalgia. Since this treatment addresses many different problems associated with CFS/FMS, it needs to be individualized to each patient. Medical Treatments Medications that provide symptom relief are frequently the first line of treatment chosen by healthcare practitioners for the person with CFS. These include medications for pain, sleep disturbances; digestive problems such as nausea, depression and anxiety, and flu-like symptoms. However, medications have not been universally successful because they tent to put a bandage on symptoms instead of addressing the root problems. Because of this, medications may need to be supplemented by the other supportive therapies that can address the root problems. Supportive Treatments People with CFS/FMS may be depressed, given the catastrophic lifestyle disruption these diseases may cause. They may also feel guilt and frustration because their symptoms were not taken seriously for such a long time. Fear can be a factor as employment and family relationships may be jeopardized by this illness. Therapies that help people to relax and improve coping skills may be helpful and include counseling for emotional and mental health, cognitive behavioral therapy, sleep management therapy, and massage. Daily Nutritional Supplementation for Energy Good overall nutrition is important for everyone, of course. However, there are several vitamins, minerals, and amino acids that can have powerful nutritional effects for a person with CFS. All of the vitamins and minerals in a chronic fatigue/fibromyalgia formula should work together synergistically to help improve energy levels and overall health. Here are some key nutrients to look for in an energy formula: Vitamins, Minerals & Other Key Ingredients Vitamin A: Essential for healthy skin and mucous membrane integrity, healthy immune system responses and healthy bone growth and healthy reproductive processes. Vitamin A in the form of beta-carotene is an antioxidant and free radical fighter. Vitamin E: Helps to relieve pain in CFS patients. Can also improve night leg cramps, which interferes with sleep. Vitamin C: Enhances immune function by increasing natural killer cells, B and T cells. Can prevent chronic bladder infections by acidifying urine. Vitamin D: Regulates immune functions of monocytes and neutrophils. Neutraphils are white blood cells that ingest invasive bacteria, and act as the first line of defense once bacteria makes it past the skin barrier. Magnesium: Involved with immune support. Working with malic acid, enhances immune function by increasing natural killer cells. Magnesium is also critical for the relief of muscle pain. Inositol: Enhances immune function by increasing natural killer cells. Malic Acid: Working with magnesium, improves energy levels by improving cellular functions. Especially important in muscle metabolism. Betaine: Works with B vitamins to synthesize amino acids, and acts as a precursor to SAM-e. SAM-e (S-adenosylmethionine) is a naturally-occurring molecule in the body, and may have an effect on overall mood elevation. Amino Acids: Glycine, Serine, Taurine, Tyrosine are essential for the production of energy in the body. Also essential for brain function. Zinc: Supports the immune system by enhancing neutrophils activity and supporting healthy antigen-antibody binding. Selenium: Supports immune function by enhancing antibody production. Fructooligosaccharides: Provides nutrition for good bacteria in the intestinal tract, improving digestion and healthy microflora. All of the vitamins, minerals, and other nutritional supplements on the list are important to ensure recovery from chronic fatigue syndrome. To ensure that your nutritional supplement regimen contains all of these ingredients, look for a powdered supplement formulated specifically for CFS/FMS sufferers that can be reconstituted in a beverage of your choice. A powdered drink mix is a pleasant, easy way to ensure that you are taking all of the needed vitamins, minerals, and amino acids that will give you the needed energy to recover from your illness. B Vitamin Complex for Energy In addition to the powdered energy drink mix, it is important that you also take a vitamin B-complex supplement specifically formulated for people with CFS/FMS. The B vitamin formula, which should include niacinamide, thiamin, riboflavin, vitamin B6, folic acid, vitamin B12, pantothenic acid, and choline, is especially important to restore the energy production needs of your body, as well as for mental function. It is also important to make sure that the dosages are high enough CFS/FMS needs. The chart in the next column lists the B vitamins that are critical for people suffering from CFS/FMS. B Vitamins Effect on Chronic Fatigue Syndrome Studies have demonstrated that people with CFS/FMS are often deficient in many of the B vitamins, which tends to worsen their symptoms of fatigue and mental “fogginess” and ultimately lead to a weakened immune system. B vitamins - Effect on Energy Thiamine (B1) - Essential in the process of energy production. This vitamin also removes lactic acid from muscles, which causes them to be sore in fibromyalgia patients. Riboflavin (B2) - Riboflavin (vitamin B2) is crucial in the production of body energy. Supports healthy gluthathione reductase activity, which helps maintain gluthathione, a major protector against free radical damage. Vitamin B2 itself also has antioxidant qualities. Niacinamide(B3) - Essential vitamin that is a component of the body’s energy furnace, helping to improve fatigue and “brain fog”. Pantothenic Acid (B5) - This vitamin improves adrenal gland function, which will boost energy levels. It can also aid in weight loss by decreasing appetite. Vitamin B6 - Working along with thiamine, this vitamin is critical in the process of energy production. Vitamin B12 - Important for brain function and nerve repair. Aids in relieving fatigue symptoms in CFS patients. Folic Acid - Aids in strengthening the immune system, and aids in mental clarity and concentration. Q. What other supplements can help me with CFS? A. Many people with CFS/FMS are suffering from adrenal burnout. Adrenal burnout occurs when the adrenal glands are constantly producing cortisol in response to chronic stress like that seen in cases of CFS. Over time, this exhausts the adrenal reserve, meaning the adrenal gland can no longer increase cortisol production in response to stress. The good news is that changes in our hormone levels can return to normal when stress is decreased. However, in cases of CFS that return to normal can be made much simpler by using a glandular therapy regimen to ensure healthy cortisol levels and adrenal function. Glandular therapy uses the concentrated forms of bovine (cow) or porcine (pig) glands to improve the health of our glands. Pioneers in the field of endocrinology (the study of hormones) hypothesized that glandular extracts work by providing nutrients the body lacks and thus repairing the malfunctioning gland. Adrenal Extract If CFS has left your adrenal glands in a stressed-out state, you should see great results by taking adrenal supplements. Be sure to buy an adrenal extract supplement that contains both whole adrenal and adrenal cortex extracts. The best adrenal supplement should also contain vitamin C, vitamin B6, L-tyrosine, betaine, pantothenic acid and licorice. Licorice contains glycyrrhizin, which is broken down into glycyrrhizic or glycyrrhetinic acid. This compound inhibits the activity of an enzyme that turns active cortisol into inactive cortisol. While in high amounts (greater than 100 mg of glycyrrhizic acid/day), licorice administration causes hypertension, no such effects have been observed at lower doses. Experts have speculated that inhibition of the cortisol-converting enzyme may reduce cortisol-related symptoms associated with adrenal insufficiency. The adrenal glands use these nutrients to manufacture cortisone and other compounds. It just makes sense to purchase an adrenal supplement with these supportive ingredients. The Road to Recovery-Adequate Sleep Disordered sleep is the underlying process that drives many of the symptoms of CFS/FMS. The most effective way to eliminate pain in CFS/FMS is to get seven to nine hours of deep sleep each night. However, getting adequate sleep is easier said than done for CFS sufferers with underlying fibromyalgia symptoms. The muscle knots of fibromyalgia make it uncomfortable to lie in one position for an extended time, causing difficulty in returning to deep sleep. Because of this, people with CFS/FMS do not stay in deep stages of sleep to recharge their “batteries.” In addition, poor sleep can cause and be caused by the suppression of the hypothalamus gland, which causes the brain to think it is daytime instead of night time. It may be helpful to use herbal products to promote good quality sleep. There are many natural supplements that are marketed as sleep formulas. To get the best results, it is very important that the right ingredients are in the sleep formula you buy. Therefore, it is important to look for an herbal sleep formula that is especially formulated for people with CFS/FMS. The combination of herbs is important as each herb addresses a different aspect of sleeplessness and muscle tension. Ingredients - Effect on Sleep Wild Lettuce - Has been found to have sedative effects. Hops - Acts as mild sedative and has a sleep-inducing effect. Jamaica Dogwood Has been found to be mildly sedative and is often used for anxiousness. L-Theanine - Causes significant increases of neurotransimitter concentrations in the brain, which promotes muscle relaxion and improves sleep. Valerian - This herb has been clinically studied for its ability to improve sleep quality. Passionflower - This herb eases nervousness and insomnia. Putting It All Together After a good night’s rest, a powdered energy drink mix formulated for people with CFS/FMS should be drunk along with a well-balanced breakfast as discussed earlier. In addition to the nutritional beverage mix, a vitamin B complex supplement designed specifically for CFS sufferers, also discussed earlier, containing niacinamide, thiamin, riboflavin, vitamin B6, vitamin B12, pantothenic acid, and choline, should be taken every morning. The nutritional drink mix and the vitamin B complex supplement will ensure that your body has all the vitamins, minerals, amino acids, and other nutrients, to combat your overwhelming fatigue, pain, and “brain fog.” Taking a daily adrenal supplement, like the one discussed earlier, will provide the much-needed (and often depleted) nutrients your body may be lacking, and help you recover lost energy. Together, these four interventions: sleep formula; morning energy drink; energy B complex supplement; and an adrenal complex- can make an incredible difference that you should begin to notice within 2-3 weeks of starting this program. Conclusion Chronic fatigue syndrome and fibromyalgia are complex physical diseases with physical causes. The unrelenting symptoms of fatigue, pain, and mental fogginess can be overwhelming and frightening. Partnering with a healthcare practitioner specializing in CFS and utilizing different medical treatments, supportive therapies, and lifestyle changes are healthy ways to combat chronic fatigue syndrome. And taking nutritional supplements formulated specifically for people with CMS/FMS that help boost energy or help you get a good night’s sleep can give you critical control over the outcome of your illness and set you on the road to recovery.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1475) Mega-Folinic - Bio-Active Form of Folic Acid
Date:
January 31, 2007 03:59 PM
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1448) HDL Booster - Boost your good cholesterol
Date:
March 16, 2006 12:51 PM
HDL BOOSTER
(Product No. 02922)
DESCRIPTION:
HDL Booster is a physician-developed dietary supplement that has been clinically shown to increase good cholesterol levels, particularly HDL-2, the best form of cholesterol.* The formula combines essential vitamins and minerals, at levels recommended by the American Heart Association (AHA), with key amino acids, powerful antioxidants, and traditional herbal extracts to provide superior support for cardiovascular health.*
HDL Booster:
· Formulated by Dr. Dennis Goodman, Chief of Cardiology at
· Clinically studied to increase good cholesterol levels up to 23%*1
· All-inclusive formula; includes ingredients recommended in accordance with the American Heart Association
· Replaces the CoQ10 depleted by cholesterol lowering (statin) drugs.*2
STRUCTURE/FUNCTION:
HDL Booster has been clinically shown to increase HDL cholesterol levels.* HDL Booster also supports healthy cholesterol and healthy triglyceride levels already within the normal ranges.* By reducing C-reactive protein levels, HDL Booster helps support the body’s natural anti-inflammatory response.*
FORMULA:
Two tablets (one serving) contain:
Vitamin C (ascorbic acid) 148 mg
Vitamin E (as natural mixed tocopherols) 35 IU
Niacin (as niacinamide) 21 mg
Vitamin B6 (as pyridoxine HCl) 3 mg
Folic Acid 301 mcg
Vitamin B12 (as cyanocobalamin) 20 mcg
Magnesium (from magnesium amino acid chelate) 10 mg
Selenium (as L-selenomethionine) 49 mcg
Proprietary Blend 388 mg
hawthorn (Crategus oxyacantha) berry extract,
taurine, garlic (Allium sativum) bulb, grape seed (Vitis
vinifera) extract, grape skin (Vitis vinifera) extract,
N-acetyl-L-cysteine, alpha-lipoic acid, soy (Glycine
max) isoflavones, tocotrienols
L-Arginine (as L-arginine HCl) 153 mg
L-Carnitine (as L-carnitine L-tartrate) 51 mg
Coenzyme Q10 (CoQ10)(ubiquinone 10) 25 mg
Policosanol 7 mg
Other ingredients: See label for most current information.
Contains no: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or preservatives. This product contains natural ingredients; color variations are normal.
INTRODUCTION:
Cholesterol, the soft, waxy substance present among the lipids (fats) in the bloodstream and in all cells, is important for wide variety of physiological functions. It is essential for the formation of cellular membranes, necessary for the production of bile salts, and also plays a role in the synthesis of certain hormones.3-5
Cholesterol is both produced by the body and obtained from food. Endogenous cholesterol is formed by human cells, particularly liver cells, whereas exogenous cholesterol is absorbed through the gastrointestinal tract from food.3,4
Because cholesterol can not be metabolized for energy, it must be removed from the body once it has served its function. The major route of removal is through the liver, where it is processed and subsequently excreted from the body.3,4
Types of Cholesterol
Cholesterol is lipophilic (“fat loving” or water insoluble) by nature. It can not be dissolved in the blood, and must, therefore, be transported by carriers known as lipoproteins. These carriers are classified by density, with LDL (low density lipoproteins) and HDL (high density lipoproteins) being the most common.4,5
LDL is often referred to as “bad” cholesterol. LDLs carry cholesterol throughout the body. Conversely, HDL, or “good” cholesterol, is responsible for carrying cholesterol away from the arteries to the liver where it is eventually processed and eliminated from the body.3,4,6
Scientific studies have shown that both types of cholesterol are important indicators of cardiovascular health. But recent research, focusing on the beneficial subtypes of HDL, has found that certain fractions of HDL may be more supportive of cardiovascular health than others. The two most notably supportive HDL fractions are HDL-2 and HDL-3.7
The smaller HDL-3 is synthesized by the liver and intestines. This form, which is known as “free cholesterol-rich” HDL, scavenges or “scoops up” free cholesterol. The cholesterol is then chemically altered by the addition of an ester group. When sufficient cholesterol is esterified, HDL-3 becomes HDL-2, which is therefore referred to as “cholesterol ester-rich” HDL. HDL-2 is larger in size and has been shown to be more cardiosupportive than HDL-3.*7
HOW IT WORKS:
HDL is known to possess antioxidant activity and to help balance the body’s natural anti-inflammatory response, both of which are important for cardiovascular health, but its most important function is the role it plays in cholesterol transport.6,8 High levels of HDL cholesterol are also associated with reduced platelet activity, another key indicator of arterial and venous health.9
Both HDL and LDL levels are important indicators of healthy cardiovascular function.* Therefore, supplements that increase the level of good cholesterol can profoundly impact heart health.* In 2002, an open label pilot study was conducted at
The following chart summarizes the benefits of each of the ingredients in HDL Booster:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1238) SAMe (S-Adenosylmethionine)
Date:
December 17, 2005 09:42 AM
Supports Healthy Nervous System and Joint Function Vital For Over 35 Biochemical Reactions Necessary For Optimum Health Promotes a Healthy Mood As the building blocks of protein, amino acids are vital to health. Next to water, amino acids in the form of proteins make up the greatest portion of our body weight. They comprise tendons, muscles and ligaments; organs and glands; hair and nails; important bodily fluids, and are a necessary part of every cell in the body. There are over 20 amino acids, separated into two categories – essential and non-essential. Essential amino acids are those that cannot be manufactured by your body, hence, it is essential that you obtain them from your diet. Non-essential amino acids can be manufactured by your body, however, your body must have the right combination of essential amino acids and supporting nutrients to optimize healthy protein maintenance, so supplementation may be desirable. Amino acids are not only absolutely integral to life, they can have a profound impact upon how clearly we think and how well we feel. SAMe (S-Adenosylmethionine) SAMe (S-adenosylmethionine) is a naturally occurring combination of the amino acid methionine and ATP (adenosine triphosphate), the body’s primary energy molecule. In this form it is sometimes referred to as “active methionine”. Research indicates that SAMe plays a vital role in nervous system health and normal cognitive function.* SAMe may support nervous system function by increasing the synthesis and recycling of certain neurotransmitters and enhancing the sensitivity of nerve receptors. SAMe is believed to positively affect a number of neurotransmitters, including serotonin, dopamine, noradrenaline and norepinephrine. Although the mechanism for SAMe’s impact upon neural function is not fully understood, there is no doubt that SAMe’s capacity as a methyl donor is of critical importance. As a methyl donor SAMe assists the body in the creation of complex organic compounds necessary for normal healthy function. Your body uses these new compounds for numerous purposes, including brain function and detoxification. This process, known as methylation or transmethylation, is vital to your body’s maintenance. SAMe may be the most effective of all methyl donors discovered to date. Research has shown that SAMe is the only methyl donor with the potential to increase transmethylation in the brain, which helps to protect it from homocysteine damage as well as increasing production of glutathione, one of the body’s most effective antioxidants. Research into the biosynthesis of SAMe has established a clear link between SAMe and folic acid, or folate. Folic Acid has been proven to provide support for healthy nervous system function and a healthy mood, and researchers believe these two nutrients work together to beneficially affect monoamine systems, which directly affect mood and cognitive function.* SAMe has also been shown to improve the synthesis of phospholipids for use in the brain, probably one of the most beneficial effects SAMe has on brain health. The benefits of SAMe extend beyond the brain and throughout the human body. For example, it may also aid in the repair of myelin, the sheath of fatty material that surrounds nerves and nerve cells everywhere in our nervous system. It’s found in all human tissue and organs and is available for use by your body in over 35 different biochemical reactions necessary for optimal health. SAMe may support joint health through transulfuration, a process that takes a certain amount of sulfur from SAMe to create glucosamine and chondroitin sulfates. This enhances proteoglycan synthesis, the molecule responsible for keeping articular (joint) cartilage lubricated. As mentioned earlier, SAMe is also important for the production of glutathione, a powerful free radical scavenger that defends your body from toxic agents and is necessary for liver detoxification. SAMe was first isolated in 1952 by G.L. Cantoni at the Laboratory of Cellular Pharmacology at the National Institutes of Health, Bethesda, Maryland. Four years later, Cantoni and a co-worker found that SAMe synthesis involves methionine and ATP. They also found that it exists in the human body only temporarily, making production in a supplemental form difficult. It took nearly ten years until improvements in technology permitted SAMe research to advance. With the discovery of a method to stabilize SAMe that overcame these manufacturing problems, U.S. patents were granted to allow the production of SAMe in a stabilized form. SAMe in its ion form, as found in human cells, has a very short life span and is rapidly metabolized into other necessary compounds as needed. Therefore, it must be manufactured in a stabilized form to prevent rapid degradation as a supplement. Once tableted, it must be enteric coated to preserve stability. This technology was not readily available until the 1990’s, hence SAMe’s long road to mainstream popularity. Dr. Joseph Zhou, Director of Laboratory Methods here at NOW, is credited with significantly improving the analytical methodology used to assure potency levels in supplemental SAMe. His work is one of the reasons SAMe is available as a supplemental with stable, guaranteed
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1019) Is there a cure for chronic fatigue syndrome?
Date:
December 10, 2005 03:19 PM
A. Treating chronic fatigue syndrome presents a significant challenge to people with CFS and their healthcare practitioners. Recently, a published placebo-controlled study (of which I was the lead investigator) showed that when using an integrated treatment approach, over 85 percent of CFS and fibromyalgia patients can improve, often dramatically. The full text of this study can be seen at ‘www.endfatigue.com’. An editorial in the April 2002 issue of the Journal of the American Academy of Pain Management noted that this treatment, which I developed, is now a highly effective and excellent part of the standard of practice for treatment of fibromyalgia. Since this treatment addresses many different problems associated with CFS/FMS, it needs to be individualized to each patient. Medical Treatments Medications that provide symptom relief are frequently the first line of treatment chosen by healthcare practitioners for the person with CFS. These include medications for the pain, sleep disturbances’ digestive problems such as nausea, depression and anxiety, and flu-like symptoms. However, medications have not been universally successful because they tend to put a bandage on symptoms instead of addressing the root problems. Because of this, medications may need to be supplemented by the other supportive therapies that can address the root problems. Supportive Treatments People with CFS? FMS may be depressed, given the catastrophic lifestyle disruption these diseases may cause. They may also feel guilt and frustration because their symptoms were not taken seriously for such a long time. Fear can be a factor as employment and family relationships may be jeopardized by this illness. Therapies that help people to relax and improve coping skills may be helpful and include counseling for emotional and mental health, cognitive behavioral therapy, sleep management therapy, and massage. Daily Nutritional Supplementation for Energy Good overall nutrition is important for everyone, of course. However, there are several vitamins, minerals, and amino acids that can have powerful nutritional effects for a person with CFS. All of the vitamins and minerals in a chronic fatigue/fibromyalgia formula should work together synergistically to help improve energy levels and overall health. Here are some key nutrients to look for in an energy formula: Vitamins, Minerals & Other Key Ingredients Vitamin A: Essentail for healthy skin and mucous membrane integrity, healthy immune system responses and healthy bone grown and healthy reproductive processes. Vitamin A in the form of beta-catotene is an antioxidant and free radical fighter. Vitamin E: Helps to relieve pain in CFS patients. Can also improve night leg cramps, which interferes with sleep. Vitamin C: Enhances immune function by increasing natural killer cells, B and T cells. Can prevent chronic bladder infections by acidifying urine. Vitamin D: Regulates immune functions of monocytes and neutrophils. Neutrophils are white blood cells that ingest invasive bacteria, and act as the first line of defense once bacteria makes it past the skin barrier. Magnesium: Involved with immune support. Working with malic acid, enhances immune function by increasing natural killer cells. Magnesium is also critical for the relief of muscle pain. Inositol: Enhances immune function by increasing natural killer cells. Malic Acid: Working with magnesium, improves energy levels by improving cellular functions. Especially important in muscle metabolism. Betaine: Works with B vitamins to synthesize amino acids, and acts as a precursor to SAM-e. SAM-e (S-adenosylmethionine) is a naturally-occurring molecule in the body, and may have an effect on overall mood elevation. Amino Acids: Glycine, Serine, Taurine, Tyrosine are essential for production of energy in the body. Also essential for brain function. Zinc: Supports the immune system by enhancing neutrophil activity and supporting healthy antigen-antibody binding. Selenium: Supports immune function by enhancing antibody production. Fructooligosaccharides: Provides nutrition for good bacteria in the intestinal tract, improving digestion and healthy microflora. All of the vitamins, minerals, and other nutritional supplements on the list are important to ensure recovery from chronic fatigue syndrome. To ensure that your nutritional supplement regimen contains all of these ingredients, look for a powdered supplement formulated specifically for CFS/FMS sufferers that can be reconstituted in a beverage of your choice. A powdered drink mix is a pleasant, easy way to ensure that you are taking all of the needed vitamins, minerals, and amino acids that will give you the needed energy to recover from your illness. B Vitamin Complex for Energy In addition to the powdered energy drink mix, it is important that you also take a vitamin B-complex supplement specifically formulated for people with CFS/FMS. The B vitamin formula, which should include niacinamide, thiamin, riboflavin, vitamin B^, folic acid, vitamin B12, pantothenic acid, and choline, is especially important to restore the energy production needs of your body, as well as for mental function. IT is also important to make sure that the dosages are high enough for CFS/FMS needs. B Vitamins Effect on Chronic Fatigue Syndrome Studies have demonstrated that people with CFS/FMS are often deficient in many of the B vitamins, which tends to worsen their symptoms of fatigue and mental “fogginess” and ultimately lead to a weakened immune system.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1009) TMG Fact Sheet
Date:
December 07, 2005 02:13 PM
TMG Fact SheetNeil E. Levin, CCN, DANLA 03/07/05LIKELY USERS: People with high homocysteine levels; People with risks of developing Alzheimer’s Disease; People needing greater metabolism of fats; People with liver detoxification challenges; People consuming alcohol KEY INGREDIENTS: TMG is composed of three methyl groups attached to a glycine atom. It can “donate” methyl groups. MAIN PRODUCT FEATURES: TMG is a metabolite of the B vitamin family product called Choline. Choline has 4 methyl groups, TMG has 3 and DMG has 2. These substances plus Folic acid, Vitamin B-12 and SAM-e are all methyl donors. Methyl donors can contribute methyl groups to biological processes such as liver function, detoxification and cellular replication (production of new cells). Methylation protects the kidneys and stimulates production of the fat-transporting molecule l-carnitine. TMG helps the liver metabolize fats, preventing the accumulation of fats in the liver. It also helps to detoxify chemicals in the liver, while protecting the liver from being damaged by those chemicals. Methylation with TMG helps to convert the dangerous, inflammatory chemical homocysteine into the amino acid methionine. TMG may lower homocysteine when B-6, B-12 and folic acid cannot. ADDITIONAL PRODUCT INFORMATION: TMG is also known as Betaine and is a component of Betaine hydrochloride (Betaine HCl), a stomach acid supplement that is very acidic. But Betaine HCl is not used in the same way as TMG. TMG is not highly acidic and will not supplement low stomach acid. TMG may be useful for autistic children, along with B-6 and magnesium. It may also be useful in strengthening the body’s immune response against pathogenic bacteria. There is very preliminary evidence that TMG and methyl donors may help against some forms of seizures. DMG has been used as a sports supplement. TMG is 50% more effective than DMG in any application where the methyl groups are useful. Otherwise, they can used interchangeably. SERVING SIZE & HOW TO TAKE IT: One serving per day, or up to 6,000 mg., as needed. COMPLEMENTARY PRODUCTS: SAM-e, Milk Thistle (Silymarin), Dr. Verghese’s Liver Detoxifier & Regenerator, Antioxidants, NAC, Homocysteine Regulators, D-Flame, Detox Support CAUTIONS: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. People with Parkinson’s or taking L-dopa should not use methyl donors like TMG without a physician’s specific approval and supervision. There are no other known drug interactions with TMG. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This is not an official publication by any company, nor has this information been screened or approved by the FDA or any private company. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES: General: Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004 Sep;80(3):539-49. Review. PMID: 15321791 Methylation: Barak AJ, Tuma DJ. Betaine, metabolic by-product or vital methylating agent? Life Sci 1983;32:771-4 [review]. Benson R, Crowell B, Hill B, et al. The effects of L-dopa on the activity of methionine adenosyltransferase: relevance to L-dopa therapy and tolerance. Neurochem Res 1993;18:325–30. Chambers ST. Betaines: their significance for bacteria and the renal tract. Clin Sci 1995;88:25-7 [review]. Charlton CG, Crowell B Jr. Parkinson’s disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav 1992;43:423–31. Charlton CG, Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol 1994;9:149–61. Cheng H, Gomes-Trolin C, Aquilonius SM, et al. Levels of L-methionine S-adenosyltransferase activity in erythrocytes and concentrations of S-adenosylmethionine and S-adenosylhomocysteine in whole blood of patients with Parkinson’s disease. Exp Neurol 1997;145:580–5. Crowell BG Jr, Benson R, Shockley D, Charlton CG. S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson’s disease-like symptoms. Behav Neural Biol 1993;59:186–93. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review]. Homocysteine: Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol. 2004;51(2):405-13. Review. PMID: 15218538 Gahl WA, Bernardini I, Chen S, et al. The effect of oral betaine on vertebral body bone density in pyridoxine-non-responsive homocystinuria. J Inherit Metab Dis 1988;11:291-8. Olthof MR, van Vliet T, Boelsma E, Verhoef P. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003 Dec;133(12):4135-8. PMID: 14652361 Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab. 2005 Feb;6(1):15-22. PMID: 15720203 Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr. 2002 Nov;76(5):961-7. PMID: 12399266 Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review]. van Guldener C, Janssen MJ, de Meer K, et al. Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients. J Intern Med 1999;245:175-83. Wendel U, Bremer HJ. Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency. Eur J Pediatr 1984;142:147-50. Wilcken DE, Wilcken B, Dudman NP, Tyrrell PA. Homocystinuria—the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983;309:448-53. Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathionine beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive patients. Metabolism. 1985 Dec;34(12):1115-21. PMID: 3934499 Liver function: Babucke G, Sarre B. Clinical experience with betain citrate. Med Klin 1973;68:1109-13 [in German]. Barak AJ, Beckenhauer HC, Badakhsh S, Tuma DJ. The effect of betaine in reversing alcoholic steatosis. Alcohol Clin Exp Res 1997;21:1100-2. Barak AJ, Beckenhauer HC, Matti J, Tuma DJ. Dietary betaine promotes generation of hepatic S-adenosylmethioine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res 1993;17:552-5. Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996;13:395-8 [review]. PMID: 8836329 Freed WJ. Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine. Pharmacol Biochem Behav. 1985 Apr;22(4):641-3. PMID: 2581277 Junnila M, Barak AJ, Beckenhauer HC, Rahko T. Betaine reduces hepatic lipidosis induced by carbon tetrachloride in Sprague-Dawley rats. Vet Hum Toxicol 1998;40:263-6. Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May;124(5):1488-99. PMID: 12730887 Kettunen H, Tiihonen K, Peuranen S, Saarinen MT, Remus JC. Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidia-infected broiler chicks. Comp Biochem Physiol A Mol Integr Physiol. 2001 Nov;130(4):759-69. PMID: 11691612 Kim SK, Kim YC, Kim YC. Effects of singly administered betaine on hepatotoxicity of chloroform in mice. Food Chem Toxicol 1998;36:655-61. McCarty MF. Co-administration of equimolar doses of betaine may alleviate the hepatotoxic risk associated with niacin therapy. Med Hypotheses. 2000 Sep;55(3):189-94. PMID: 10985907 Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol 1998;44:249-55. Poschl G, Stickel F, Wang XD, Seitz HK. Alcohol and cancer: genetic and nutritional aspects. Proc Nutr Soc. 2004 Feb;63(1):65-71. Review. PMID: 15070439 Semmler F. Treatment of liver diseases, especially of fatty liver with betaine citrate. Ther Ggw 1977;116:2113-24 [in German]. Zapadniuk VI, Panteleimonova TN. [Cholagogic effect of trimethylglycine in normal animals of different ages and in experimental atherosclerosis] Biull Eksp Biol Med. 1987 Jul;104(7):30-2. Russian. PMID: 3620644 Autism & Seizures: Rimland B. Seizures, Vitamin B6, DMG, and Sudden Speech. Autism Research Review International. 1996;10(2):1. Roach ES, Carlin L. N,N-dimethylglycine for epilepsy. N Engl J Med. 1982;307:1081-82. Vitamin B6/DMG. Letters to the Editor, Autism Research Interview International. 1994;8(2):6. Immunity: Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med. Apr1990;115(4):481-6. Safety: Hoorn AJ. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res. 1989 Apr;222(4):343-50. PMID: 2468082
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=988) Research on SAMe....
Date:
October 26, 2005 12:49 PM
Two groups of researchers have conducted analyses of trials that utilized SAM-e for mood enhancement. One meta-analysis was published in 1994. The researchers analyzed the efficacy of SAM-e in oral or injection forms based on published trials dated between 1973 and 1992. The authors concluded that there was a significant improvement of 17 to 38% seen in trials of SAM-e compared to placebo response. They state that the efficacy of SAM-e was superior to placebo and its administration caused few side effects.5 A second review was published in 2002. The authors analyzed studies in which SAM-e doses ranged from 200 to 1600 mg daily. They also found a significant effect of SAM-e in comparison to placebo, with an evident rapid onset of effect at enhancing mood.6 Promotes Joint Comfort and Mobility* As a sulfur donor to connective tissue, SAM-e plays a major role in protecting the integrity of cartilage tissue. An in vitro trial assessed the actions of SAM-e in cultured human articular chondrocytes. At a concentration of 10 micrograms/ml, proteoglycan synthesis and sulfate residue incorporation in chondrocytes was shown to be 60% higher than control levels. Based on these results, it was shown that SAM-e has a positive influence on the growth and health of cartilaginous connective tissue.7 In a double-blind trial with 734 individuals with compromised joint health. SAM-e given orally at a dose of 1200 mg daily for 30 days was shown to significantly promote joint comfort compared to placebo, with a high level of tolerability and low incidence of side effects. The researchers concluded that SAM-e is a highly effective supplement for enhancing joint comfort.8 Another trial evaluated the response of individuals experiencing discomfort in the joints to a regimen of 1200 mg SAM-e for 1 week followed by 800 mg for the second week, and then 400 mg for weeks 3 through 8. This open trial of 20, 641 people showed a strong ability of SAM-e to enhance feelings of comfort within the joints. The treatment was rated as “very good” or “good” in 71% of the participants, with an additional 21% rating the treatment effect as “moderate”.9 In a long-term trial lasting 24 months, SAM-e was given to 108 participants with compromised joint function. Individuals were given 600 mg orally per day for the first two weeks followed by 400 mg daily for the remainder of the trial. Individuals experienced significant enhancements in joint comfort, with dramatic improvements noted after 2-4 weeks of treatment. Improvements continued to 6 months and beyond.10 In addition to the above studies, a review was conducted in 1987 to assess the results of SAM-e supplementation in clinical trials for enhancing joint mobility and function. Over 22,000 individuals had participated in the clinical trials that were the subject of this review. The author concluded from his analysis that SAM-e was shown to be highly efficacious, rivaling or surpassing the effectiveness of other treatments, and also possessing a high level of safety.11 Because of this, SAM-e may be the treatment of choice for enhancing joint function. Supports Liver Health and Detoxification* SAM-e supplementation can have profound benefits on liver function. These benefits center around its function as the major methyl donor in the liver, as well as its lipotropic activity. SAM-e also enhances the production of the antioxidant glutathione. A number of trials have been conducted showing the ability of SAM-e to support liver detoxification functions and enhance liver health in individuals susceptible to toxin-induced liver compromise. SAM-e has the ability to normalize liver function by increasing the activity of enzymes needed to upregulate liver detoxification. These effects are comprehensive and rapid. Dosages used in these studies range from 600 mg to 1600 mg daily for 2 months to two years.12,13,14 In these trials, significant benefits of SAM-e supplementation were seen over placebo. Safety SAM-e has an excellent safety profile and is considered well-suited for long term use based on multiple clinical trials. Individuals diagnosed with manic depression should avoid SAM-e supplementation, as it may aggravate the manic phase *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Scientific References 1. Agnoli A, Andreoli V, Casacchia M, Cerbo R. Effect of s-adenosyl-l-methionine (SAMe) upon depressive symptoms. J Psychiatr Res. 1976;13(1):43-54. 2. De Leo D. S-adenosylmethionine as an antidepressant. Curr Ther Research. 1987;41(6):865-70. 3. Kagan BL, Sultzer DL, Rosenlicht N,Gerner RH. Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 1990 May;147(5):591-5. 4.Salmaggi P,Bressa GM,Nicchia G,Coniglio M,La Greca P,Le Grazie C.Doubleblind, placebo-controlled study of S-adenosyl-L-methionine in depressed postmenopausal women. Psychother Psychosom. 1993;59(1):34-40. 5. Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressant: metaanalysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. 6.Mischoulon D, Fava M. Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. Am J Clin Nutr. 2002 Nov;76(5):1158S-61S. 7. Harmand MF, Vilamitjana J,Maloche E, Duphil R, Ducassou D. Effects of Sadenosylmethionine on human articular chondrocyte differentiation. An in vitro study. Am J Med. 1987 Nov 20;83(5A):48-54. 8. Caruso I, . Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. Am J Med. 1987 Nov 20;83(5A):66-71. 9. Berger R, Nowak H. A new medical approach to the treatment of osteoarthritis. Report of an open phase IV study with ademetionine (Gumbaral). Am J Med. 1987 Nov 20;83(5A):84-8. 10. Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med. 1987 Nov 20;83(5A):89-94. 11. di Padova C. S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies. Am J Med. 1987 Nov 20;83(5A):60-5. 12. Frezza M, et al. S-adenosylmethionine counteracts oral contraceptive hepatotoxicity in women. Am J Med Sci. 1987; 293(4):234-238. 13. Frezza M, Surrenti C, Manzillo G, Fiaccadori F, Bortolini M, Di Padova C. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology. 1990 Jul;99(1):211-5. 14. Mato JM, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol. 1999 Jun;30(6):1081-9.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=900) Selenium for Prostate
Date:
October 18, 2005 09:35 AM
Selenium - There have been many studies showing a direct connection between selenium and prostate cancer, and most nutritionist agree, it’s hard to get enough of it on a daily basis without taking a nutritional supplement. In the now famous Clark Study, a 63% reduction in prostate cancer was found in men who received 200 micrograms of selenium from a selenium-enriched yeast containing mostly seleniumethionine. The conclusion? Eat more tuna, Brazil nuts, and sunflower seeds, and to guard against gaps in your diet, take a daily supplement containing 200 micrograms (MCG) of selenium from selenium-enriched yeast or seleniumethionine! Another Study conducted at Stanford University found that low plasma selenium is associated with a four to five-fold increase of prostate cancer. These results support the hypothesis that supplemental selenium may reduce the risk of prostate cancer. And because plasma selenium decreases with patient age, supplementation is particularly beneficial to older men.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=844) Benefits of Total Daily Formula
Date:
October 13, 2005 04:45 PM
Benefits of Total Daily Formula All fruits and vegetables contain carotenes, the plant pigments responsible for the rich variety of colors we enjoy in the natural world. Beta carotene is the most familiar member of the carotene family. But beta carotene never exists by itself; it is always found with other carotenes in foods. We need more than just beta carotene alone. Carotenes are powerful antioxidants, which means they help reduce the body's free radical burden. Research suggests that carotenes work as a team to keep us healthy.5 Total Daily Formula provides beta carotene, alpha carotene, lutein, lycopene, zeaxanthin and cryptoxanthin from natural sources such as algal extracts, carrot oil, marigold and tomatoes (Caromix®). Total Daily Formula uses only corn-free vitamin C (ascorbic acid). The full daily intake of 6 tablets provides an exceptionally generous 800 mg of vitamin C. Total Daily Formula supplies ample amounts of all essential B vitamins. Vitamin B3 is given as niacin plus an extra helping of niacinamide, the non-flush form of this important vitamin. The body uses pantothenic acid (vitamin B5) to deal with stress, so the formula provides 150 mg, which is 15 times the RDA. Vitamin B6 is another B vitamin people may run short of, so 60 mg -- 30 times the RDA -- is supplied. The formula contains 800 mcg of folic acid, the vitamin now recognized by the FDA as essential for prevention of neural tube defects in unborn babies. Folic acid also helps prevent accumulation in the body of homocysteine, a metabolite of the amino acid methionine.6 A high blood homocysteine level is now considered to be a risk factor for heart disease.7 Flavonoids, also known as "bioflavonoids." are plant pigments widely distributed throughout the plant kingdom.8 Previously known as "Vitamin P," because they help reduce capillary permeability (leakiness) flavonoids are now regarded as "semi-essential" non-vitamin nutrients that benefit health in a variety of ways.9 In addition to maintaining the structure of blood vessels, flavonoids function as versatile antioxidants. Flavonoids protect vitamin C from destruction by free-radicals, helping to preserve the body's vitamin C supply.10 Total Daily Formula provides 100 mg of pure flavonoids from 112 mg of citrus extract. Three superior sources of Calcium Total Daily Formula contains three of the best absorbed and most effective forms of calcium available. MCHC (microcrystalline hydroxyapatite concentrate) is a naturally-derived compound composed of calcium, plus all the minerals and organic factors in living bone tissue. MCHC has been clinically shown to benefit bone health.11 Calcium citrate malate is a very well-absorbed form of supplemental calcium shown in recent research to be helpful for postmenopausal women.12,13 Calcium glycinate is chelated with the amino acid glycine, one of the most efficient mineral carriers for effective absorption.14,15 Magnesium is essential for strong bones and healthy hearts. This versatile mineral also regulates nerve function, keeps muscles relaxed and coordinates activity of over 300 enzymes in the body.16 Total Daily Formula contains 100 percent magnesium glycinate for exceptional absorption and gentleness on the intestinal tract.17 Magnesium glycinate has been clinically tested on people with severe malabsorption with excellent results.18 Total Daily Formula provides - in addition to zinc, chromium, selenium and iodine - vanadium and molybdenum. Vanadium helps maintain normal blood sugar.19 Molybdenum works as a co-factor for enzymes that help detoxify and eliminate foreign substances from the body.20 Bioperine® for Enhanced Absorption Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. 21 Betaine HCL - supplies HCL (hydrochloric acid) to assist digestion. All natural tablet coating made of vegetable concentrate and beta carotene.
Scientific References 2. Morgan, K.J. et. al. Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition. 1985;4:195-206. 3. Lakschmanan, F.L., Rao, R.B., Kim, W.W., Kelsay, J.L. Magnesium intakes, balances and blood levels of adults consuming self-selected diets. American Journal of Clinical Nutrition 1984;40:1380-89. 4. Mertz, W. The Essential Trace Elements. Fed. Proc. 1970;29:1482. 5. Perry, G. Byers, T. Dietary carotenes, vitamin C and vitamin E as protective antioxidants in human cancers. Annu. Rev. Nutr. 1992;12:139-59. 6. Landgren, F., et. al. Plasma homocysteine in acute myocardial infarction: Homocysteine-lowering effect of folic acid. J Int Med 1995;237:381-88. 7. Clarke, R., et. al. Hyperhomocysteinemia: an independent risk factor for vascular disease. New Eng J Med 1991;324:1149-55. 8. Havsteen, B. Flavonoids, a class of natural compounds of high pharmacological potency. Biochemical Pharmacology 32(7):1141-48. 9. Middleton, E. The flavonoids. TIPS 1984; 5:335-38. 10. Roger, C.R. The nutritional incidence of flavonoids: some physiological and metabolic considerations. Experientia 44(9):725-804. 11. Dixon, A. St. J. Non-hormonal treatment of osteoporosis. British Medical Journal 1983;286(6370):999-1000. 12. Smith, K.T. et. al. Calcium Absorption from a new calcium delivery system (CCM). Calcif Tissue Int 1987;41:351-352. 13. Dawson-Hughes, B. et. al. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. New England Journal of Medicine 1990 Sep 27;323(13):878-883. 14. Albion Research Notes Vol. 4, No. 1, ©Albion Laboratories Jan,1995. 15. Ashmead, H.D. Intestinal Absorption of Metal Ions and Chelate, Springfield: Charles C Thomas, ©1985. 16. Wester, P.O., Dyckner, T. The importance of the magnesium ion. Magnesium deficiency-symptomatology and occurrence. Acta Med Scand 1992; (Suppl) 661:3-4. 17. Albion Research Notes Vol. 3, No. 1, ©Albion Laboratories, Feb 1994. 18. Schutte, S., et. al. Bioavailability of Mg diglycinate vs MgO in patients with ileal resections. Abstract 115, AJCN 1992;56(4). 19. Cohen, N. et. al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J. Clin Invest 1995; 95:2501-09. 20. Sardesi, V.M. Molybdenum: An essential trace mineral element. Nutr Clin Pract 1993; 8:277-81. 21. Bioperine® - Nature's Bioavailability Enhancing Thermo-nutrient. Executive Summary' 1996; Sabinsa Corporation, Piscataway, N.J.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=777) HAWAIIAN NONI (Morinda citrifolia)
Date:
July 11, 2005 08:50 PM
INTRODUCTION In a time when we are more concerned than ever with issues of health, a tried and true tropical herb called noni needs t o be added t o our list of the best natural remedies. It susage over hundreds of years supports it s description as a veritable panacea of therapeutic actions. At this writing, noni continues to accrue impressive medicinal credentials, and its emergence as an effective nat ural healing agent is a timely one. Amidst rising cancer rates, the high incidence of degenerative diseases like diabetes, and the evolution of ant ibiotic resist ant bacteria and new viral strains, herbs like noni are sought after for their natural pharmaceutical properties. Unquest ionably, all of us want to know how to:
Genus Rubiaceae Common Names Indian Mulberry (India), Noni (Hawaii), Nono (Tahiti and Raratonga), Polynesian Bush Fruit, Painkiller Tree (Caribbean islands), Lada (Guam), Mengkudo (Malaysia), Nhau (Southeast Asia), Grand Morinda (Vietnam), Cheesefruit (Australia), Kura (Fiji), Bumbo (Africa) Note: This is only a small sampling of vernacular names for Morinda citrifolia. Almost every island nation of the South Pacific and Caribbean has a term for this particular plant . This booklet will refer to the herb mainly as “ noni” or M. citrifolia, and is referring primarily to Hawaiin noni. Parts Used The parts of the noni plant most used for their medicinal and nutritional purposes are the fruit, seeds, bark, leaves, and flowers. Virtually every part of the noni plant is utilized for its individual medicinal properties; however, it is the fruit portion that is regarded as its most valuable. The seeds have a purgative action, the leaves are used to treat external inflammations and relieve pain, the bark has strong astringent properties and can treat malaria, the root extracts lower blood pressure, the flower essences relieve eye inflammations and the f ruit has a number of medicinal actions. Physical Description Morinda citrifolia is technically an evergreen shrub or bush, which can grow to heights of fifteen to twenty feet . It has rigid, coarse branches which bear dark, oval, glossy leaves. Small white fragrant flowers bloom out of cluster-like pods which bear creamy-white colored fruit. The fruit is fleshy and gel-like when ripened, resembling a small breadf ruit . The flesh of the fruit is characterist ically bitter, and when completely ripe produces a rancid and very dist inctive odor. Noni has buoyant seeds that can float formont hs in ocean bodies. The wood of the inflammatory, astringent, emollient, emmenagogue, laxative, sedative, hypotensive (lowers blood pressure) , blood purif ier, and tonic. Chemical Constituents Noni has various chemical constituents. First, it has an impressive array of terpene compounds, three of which—L. Asperuloside, aucubin, and glucose— have been identified by their actyl derivatives. Both caproic and caprylic acids have been isolated.1 Second, bushfruits, a category of which noni fruit is a member, are also considered a good source of vit - amin C.2 Third, Hawaiin noni has been linked to the synthesis of xeronine in the body which has significant and widespread health implications. Last , the alkaloid cont ent of the noni fruit is thought to be responsible for its therapeutic actions. Alkaloids exhibit a wide range of pharmacological and biological act ivitiesin the human body. They are nitrogencontaining organic compounds which can react with acids to form salts and which are the basis of many medicines. The following is an in-depth chemical analysis of each plant part and it s chemical constituents.
FLOWER
FRUIT
discovered an alkaloid in the Hawaiin noni fruit which he calls proxeronine and which he believes has appreciable physiological actions by acting as a precursor to xeronine, a very crucial compound (see later sections) . In addition, a compound found in the fruit called damnacanthol is believed to help inhibit cert ain viruses and cellular mutations involved in cancer. ROOT AND ROOT BARK
Pharmacology Recent surveys have suggested that noni fruit exerts antibiotic action. In fact, a variety of compounds which have antibacterial properties (such as aucubin) have been identified in the fruit.5 The 6-Dglucopyranose pentaacet ate of the fruit extract is not considered bacteriostatic.6 Constituents found in the fruit portion have exhibited ant imicrobial action against Escherichia coli, Salmonella typhi (and other types) , Shigella paradysenteriae, and Staphylococcus aureaus. Compounds found in the root have the ability to reduce swollen mucous membrane and lower blood pressure in animal studies. Proxeronine is an alkaloid constituent found in Hawaiin noni fruit which may prompt the production of xeronine in the body. It is considered a xeronine precursor and was discovered in noni fruit by Dr. Ralph M. Heinicke. He has theorized that this proenzyme can be effective in initiating a series of beneficial cellular reactions through its involvement with the integrity of specific proteins. He points out that tissues contain cells which possess certain recept or sites for xeronine. Because the reactions that can occur are so varied, many different therapeutic actions can result when xeronine production escalates, explaining why Hawaiin noni is good for so many seemingly unrelated disorders. Damnacanthol is another compound contained in the fruit of the Hawaiin noni plant which has shown the ability to block or inhibit the cellular function of RAS cells, considered pre-cancerous cells. Body Systems Targeted The following body systems have all been effec-freeze-dried capsules, dehydrated powder or fruit, and oil. Noni plant constituents are sometimes offered in combination with other herbs. Some products contain a percent age of the fruit, bark, root and seeds for their individual therapeutic properties. Satety Extracts of M. citrifolia are considered safe if used as directed; however, pregnant or nursing mothers should consult their physicians before taking any supplement . High doses of root extracts may cause constipation. Taking noni supplements with coffee, alcohol or nicotine is not recommended. Suggested Uses Ideally, noni extracts should be taken on an empty stomach prior to meals. The process of digesting food can interfere with the medicinal value of the alkaloid compounds found in Hawaiin noni, especially in its fruit . Apparently, stomach acids and enzymes destroy the specific enzyme which frees up the xeronine compound. Take noni supplements without food, coffee, nicotine or alcohol. Using supplements that have been made from the semi-ripe or light - green fruit is also considered preferable to the ripe, whit ish fruit . NONI: ITS USE AND HISTORY Noni is a tropical wandering plant indigenous to areas of Australia, Malaysia and Polynesia. It is considered native to Southeast Asia although it grows from India to the eastern region of Polynesia. Morinda citrifolia has a long history of medicinal use throughout these areas. It is thought to be the “most widely and commonly used medicinal plant prior to the European era.” 7 Centuries ago, the bushfruit was introduced to native Hawaiians, who subsequently called it “noni” and considered its fruit and root as prized medicinal agents. Among all Polynesian botanical agents of the 19th and 20th centuries, Hawaiin noni has the widest array of medical applications. Samoan and Hawaiian medical practitioners used noni for bowel disorders (especially infant diarrhea, constipation, or intestinal parasites) , indigestion, skin inflammation, infection, mouth sores, fever, contusions and sprains. Hawaiians commonly prepared noni tonics designed to treat diabetes, stings, burns and fish poisoning.8 The herb’s remarkable ability to purge the intestinal tract and promote colon health was well known among older Hawaiian and Tahitian natives and folk healers. Interestingly, field observations regarding its repu-remarkable healing agent . Wonder Herb of Island Folk Healers Common to t he thickets and forests of Malaysia and Polynesia, and the low hilly regions of the Philippine islands, noni has been cultivated throughout communities in the South Pacific for hundreds of years. Its Hawaiian use is thought to originate from inter-island canoe travel and settlement dating to before Christ . Its hardy seeds have the ability to float which has also contributed to its distribution among various seacoasts in the South Pacific region. Historical investigation has established the fact that some of Hawaii’s earliest settlers probably came viaTahiti. For this reason, Tahitian herbal practices have specific bearing on the herbal therapeutics of islands to the nort h. The very obvious similarities between the Hawaiian vernacular for herbal plants like noni and Tahitian names strongly suggests the theory of Polynesian migrations to Hawaii. Cultures native to these regions favored using Morinda citrifolia for treating major diseases and ut ilized it as a source of nourishment in times of famine.9 Noni fruit has been recognized for centuries as an excellent source of nutrition. The peoples of Fiji, Samoa and Rarat onga use the fruit in both its raw and cooked forms.10 Traditionally, the fruit was propicked before it was fully ripe and placed in the sunlight . After being allowed to ripen, it was typically mashed and its juice extracted through a cloth. Noni leaves provided a veget able dish and their resiliency made them desirable as a fish wrap for cooking. Noni’s Medical Reputation Elaborate traditionalrituals and praying rites usually accompanied the administration of noni. Int erestingly, cultures indigenous to the Polynesian islands had a significant understanding of their flora. For example, native Hawaiians maint ained a folkmedicine taxonomy t hat was considered second to none.11 Noni was not only used for medicinal purposes but for its food value, for clot hing and for cloth dyes as well. Research indicates that noni was among the few herbal remedies that islanders considered “ tried and true.” In Hawaii, trained herbal practitioners reserved the right to prescribe plant therapies.12 Records indicate that Hawaiian medical practices were based on extensive and very meticulous descriptions of symptoms and their prescribed herbal treatments. Dosages were controlled and the collection and administration of plant extracts was carefully monitored.13 In addition to Morinda, it was not uncommon for these herbal doctors to also recommend using In regard to its application for common ailments, Hawaiians and other island communities traditionally prescribed noni to purge the bowel, reduce fever, cure respiratory infections such as asthma, ease skin inflammations, and heal bruises and sprains. In other words, noni was widely used and highly regarded as a botanical medicine. A Timely Reemer gence Today, the natural pharmaceutical actions of the chemical constituents contained in noni are scientif-ically emerging as valuable bot anical medicines. Tahitian “nono” intrigued medical practitioners decades ago; however, due to the eventual emergence of synthetic drugs, interest in this island botanical diminished until recent years. Ethnobot anists are once again rediscovering why Hawaiian people havet reasured and cultivat ed Morinda citrifolia for generations. Noni is now finding its way into western therapeutics and is referred to as “ the queen” of the genus Rubiaceae. Its ability to reduce joint inflammation and target the immune system have made it the focus of the modern scientific inquiry. Dr. Ralph Heinicke has conducted some fascinating studies on the chemical constituents of the Hawaiin noni fruit. His research centers on the proxeronine content of the fruit juice and how it profoundly influences human physiology. In addition, scientific studies investigating noni as an anti-cancer agent have been encouraging. It s conspicuous attributes and varied uses have elevat edits status to one of the best of the healing herbs. Today Morinda citrifolia is available in liquid, juice, freezedried capsules, or oil forms, and is considered one of nature’s most precious botanicals. TRADITIONAL USES OF NONI Throughout tropical regions, virtually every part of Morinda citrifolia was used to treat disease or injury. Its curative properties were well known and commonly employed. PatoaTama Benioni, a member of the Maoritribe from the Cook Islands and a lecturer on island plants explains: Traditionally Polynesians use noni for basically everything in the treatment of illness. Noni is a part of our lives. Any Polynesian boy will tell you he’s had exper ience with it . We use juice from its roots, its flowers, and its fruit... my grandmother taught me to use noni from the roots and the leaves to make medicine for external as well as internal use, and for all kinds of ailments, such as coughs, boils, diseases of the skin, and cuts.15 decoctions to stimulate delayed menst ruation.
XERONINE: THE SECRET OF NONI? One informed professional on the subject of noni is Dr. Ralph Heinicke, a biochemist who has researched the active compounds of noni fruit for a number of years. He discovered that the Hawaiin noni fruit contains an alkaloid precursor to a very vital compound called xeronine. Wit hout xeronine, life would cease. In Dr. Heinicke’s view, noni fruit provides a safe and effective way to increase xeronine levels, which exert a crucial influence on cell health and protction. His research suggests that the juice from the M. citrifolia fruit contains what could technically be considered a precursor of xeronine—proxeronine. This compound initiates the release of xeronine in the intestinal tract after it comes in contact with a specific enzyme which is also contained in the fruit . Because proteins and enzymes have so many varied roles within cell processes, the normalization of these proteins with noni supplemenation could initiate avery wide variety of body responses and treat many disease condit ions. Proteins are the most important catalysts found in the body. The beauty of obtaining a precursor to xeronine from the noni fruit is that the body naturally decides how much of this precursor to convert to xeronine. Disease, stress, anger, trauma and injury can lower xeronine levels in the body, thus creat ing a xeronine deficit . Supplementing the body with noni fruit is considered an excellent way to safely and naturally raise xeronine levels. It is the research and theories of Dr. Heinicke which have made the juice of the Hawaiin noni fruit a viable medicinal substance. He writes: Xeronine is analkaloid, a substance the body produces in order to activate enzymes so they can function properly. It also energizes and regulates the body. This par-ticular alkaloid has never been found because the body makes it, immediately uses it, and then breaks it down. At no time is there an appreciable, isolable amount in the blood. But xeronine is so basic to the functioning of proteins, we would die without it . Its absence can cause many kinds of illness.17 Because so many diseases result from an enzyme malfunction, Dr. Heinicke believes that using the noni fruit can result in an impressive array of curative applications. Interestingly, he believes that we manufacture proxeronine while we are sleeping. He proposes t hat if we could constantly supply our bodies wit h proxeronine from other sources, our need to sleep would diminish.18 NONI PROCESSING How an herb is processed is crucial to how beneficial it is: this is especially true of noni, with its unique enzymes and alkaloids. Morinda citrifolia should be picked when the fruit is turning from its dark green immature color to its lighter green color, and certainly before it ripens to its white, almost translucent color. Once picked, noni, like aloe, will denature extremely quickly due to its very active enzymes. After harvesting, it should swiftly be flash frozen. This is similar to what is done to fish caught at sea to keep them f esh. This stops it from losing its potency while not damaging any of its constituents. To process noni, freeze-drying is recommended. This removes only the water without damaging any of this miracle plant’s vital enzymes and other phytonutrients like xeronine and proxeronine. This pure high-quality noni fruit juice powder is then encapsu-has a very harsh taste and an extremely foul smell, similar to the fruit it self . Other methods of processing include thermal processing, dehydrat ion and air drying. Thermal processing is generally found in liquids, while the dehydrat ed noni is then milled and encapsulated. Unfortunately both methods utilize high heat (110+°F) , which can deactivate many of the vital compounds that make noni so import ant . Air-drying is effect ive without using damaging heat but has serious quality control problems for commercial production. MODERN APPLICATIONS OF NONI Overview Noni possesses a wide variety of medicinal properties which originat e from its differing plant component s. The fruit and leaves of the shrub exert antibacterial activities. Its roots promote the expulsion of mucus and the shrinkage of swollen membranes making it an ideal therapeutic for nasal congest ion, lung infect ions, and hemorrhoids. Noni root compounds have also shown natural sedative properties as well as the ability to lower blood pressure. Leaf extracts are able to inhibit excessive blood flow or to inhibit the formation of blood clots. Noni is particularly useful for its ability to treat painful joint conditions and to resolve skin inflammations. Many people drink noni fruit extracts in juice form for hypert ension, painful menstruation, arthritis, gastric ulcers, diabetes, and depression. Recent studies suggest that its anticancer activit y should also be considered. Concerning the therapeutic potential of the Hawaiin noni fruit, Dr. Heinicke writes: I have seen the compound found in noni work wonders. When I was still investigating its possibilities, I had a friend who was a medical research scientist administer the proxeronine to a woman who had been comatose for three months. Two hour safter receiving the compound, she sat up in bed and asked where she was. . . . Noni is probably the best source of proxeronine that we have today.19 Studies and surveys combined support the ability of noni to act as an immunost imulant, inhibit the growth of certain tumors, enhance and normalize cellular function and boost tissue regeneration. It is considered a powerful blood purifier and contributor to overall homeostasis. xeronine, which appears to be able to regulate the shape and integrity of cert in proteins that individually contribute to specific cellular activities. Interestingly, this effect seems to occur after ingestion, inferring that the most active compound of noni may not be present in uneaten forms of the fruit or other plant parts. Some practitioners believe that xeronine is best obtained from a noni fruit juice precursor compound. The enzymatic reactions that occur with taking the juice on an empty stomach are what Dr. Heinicke believes set cellular repair intomotion. Cancer A study conducted in 1994 cited the anticancer activity of Morinda citrifolia against lung cancer. A team of scientists from the University of Hawaii used live laboratory mice to test the medicinal properties of the fruit against Lewis lung carcinomas which were artificially transferred to lung tissue. The mice that were left untreated died in nine to twelve days. However, giving noni juice in consistent daily doses significantly prolonged their life span. Almost half of these mice lived for more than fifty days.20 Research conclusions state that the chemical constituents of the juice acted indirectly by enhancing the ability of the immune system to deal with the invading malig-nancy by boosting macrophage or lymphocyte activit y. Furt her evaluation theorizes that the unique chemical constituents of Morinda citrifolia initiate enhanced T-cell activity, a reaction that may explain noni’s ability to treat a variety of infectious diseases. 21 In Japan, similar studies on tropical plant extracts found that damnacanthol, a compound found in Morinda citrifolia, is able to inhibit the function of KRAS- NRK cells, which are considered precursors to certain types of malignancies.22 The experiment involved adding noni plant extract to RAS cells and incubating them for a number of days. Observation disclosed that noni was able to significantly inhibit RAS cellular function. Among 500 plant extracts, Morinda citrifolia was determined to contain the most effective compounds against RAS cells. Its damnacanthol content was clinically described in 1993 as “a new inhibit or of RAS function.” 2 3 The xeronine fact or is also involved in that xeronine helps to normalize the way malignant cells behave. While they are still technically cancer cells, they no longer function as cells with unchecked growth. In time, the body’s immune system may be able to eradicate these cells. Arthritis with arthritic disease. One link to arthritic pain may be the inability to properly or completely digest proteins which can then form crystal-like deposits in the joints. The ability of noni fruit to enhance protein digestion through enhanced enzymatic function may help to eliminate this particular phenomenon. In addition, the alkaloid compounds and plant met abolites of noni may be linked to its apparent anti-inflammatory action. Plant sterols can assist in inhibiting the inflammatory response which causes swelling and pain. In addition, the antioxidant effect of noni may help to decrease free radical damage in joint cells, which can exacerbate discomfort and degeneration. Immune System The alkaloid and other chemical compounds found in noni have proven themselves to effectively control or kill over six types of infectious bacterial strains including: Escherichia coli, salmonellatyphi (and other types) , shigella paradysenteriae, and staphylo - coccus aureaus.25 In addition, damnacanthol, was able to inhibitt he early antigen stage of the Epstein- Barr virus. The bioactive components of the whole plant, combined or in separate portions, have demonst rat - ed the ability to inhibit several different strains of bacteria. Anecdotal reports support this action in that noni seems particularly effective in shortening the duration of certain types of infection. This may explain why noni is commonly used to treat colds and flu. The chemical constituents found in noni and the possibility that they stimulate xeronine production— as well as initiate alkaloid therapy—may explain noni’s reputation for having immuno-stimulatory properties. Alkaloids have been able to boost phagocytosis which is the process in which certain white blood cells called macrophages attack and literally digest infectious organisms. Interestingly, the ant it umoraction of noni has been ascribed to an immune system response which involves stimulating T-cells. tropical regions during World War II learned of the fruit’s ability to boost endurance and stamina. Native cultures in Samoa, Tahiti, Raratonga and Australia used the fruit in cooked and raw forms. M. citrifolia is considered a tonic and is especially recommended for debilitated conditions. Antioxidant The process of aging bombards the body with free radicals which can cause all kinds of degenerative diseases. The xeronine theory promoted by Dr. Heinicke submit s t hat as our bodies age, we lose our ability to synthesize xeronine. To make matters worse, the presence of many environment altoxins actually blocks the production of xeronine as well. He believes that the proxeronine content of Hawaiin noni fruit juice can help to block these actions, thereby working as an antiaging compound.26 The phytonutrients found in noni assist in promot - ing cell nourishment and prot ect ion from free radicals created by exposure to pollution and other potentially damaging agents. In addition, Morinda citrifolia contains selenium, which is considered one of the best antioxidant compounds available. Diabetes While scientific studies are lacking in this particular application of noni, Hawaiians used various parts of the plant and its fruit to treat blood sugar disorders. Anecdotal surveys have found t hat noni is current ly recommended for anyone with diabetes. Pain Killer A 1990 study found that extracts derived from the Morinda citrifolia root have the ability to kill pain in animal experiments.27 Interest ingly, it was during this study that the natural sedative action of the root was also noted. This study involved a French team of scientists who noted a significant central analgesic activity in laboratory mice.28 Dr. Heinicke has stated, “Xeronine also acts as a pain reliever. A man wit h very advanced int est inal cancer was given three months to live. He began taking the proxeronine and lived for a whole year, pain-free.” 29 Skin Healing Agent One of the most prevalent hist rical uses of noni was in poultice form for cuts, wounds, abrasions, burns and bruises. Using its fruit extract for very serious burns has resulted in some extraordinary healing. Because skin is comprised of protein, it immediately responds to the presence of xeronine. burn site throught he direct application of a noni poultice is considered quite effective by Dr. Heinicke and his colleagues, who have studied enzymatic therapy. Concerning burns, he has written: I believe that each tissue has cells which contain proteins which have receptor sites for the absorption of xeronine. Certain of these proteins are the inert for ms of enzymes which require absorbed xeronine to become active. This xeronine, by converting the body’s procol- langenase system into a specific protease, quickly and safely removes the dead tissue from burns.30 Drug Addiction The xeronine link to treat ing drug addiction is based on the notion that flooding t he brain with extra xeronine can reverse the neurochemical basis for addiction. This natural alkaloid is thought to normalize brain receptors which subsequent ly results in the cessation of physiological dependence on a certain chemical like nicotine.3 1 The potential of Hawaiin noni as a natural stimulat or for t he production of xeronine may have profound implications in treating various types of addictions. Complementary Agents of Noni
PrimaryApplications of Noni
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Date:
June 25, 2005 10:20 AM
GARLIC AS AN ANTIOXIDANT The term “antioxidant” has become a buzz word over the last decade. Defending ourselves against a wide array of chemicals, heavy metals, pollutants, radiation and poor nutrition has become a vital area of scientific focus and research. Oxidizing agents or free radicals attack our bodies constantly and have the potential to damage our cells, which compresses human tissue. Substances which have been found to help protect us from the cellular damage caused by free radicals include vitamin C, bioflavonoids, vitamin E, vitamin A, beta carotene and selenium to name a few. Garlic is not usually found on standard antioxidant lists and probably should be. Garlic has an abundance of sulfhydryl which is an excellent antioxidant. It’s important to know that raw garlic did not demonstrate this ability. In fact, raw garlic actually has some oxidant action, which is not desireable. Garlic can also help to lessen free radical damage because it has the ability to protect against radiation. In this regard, it may significantly decrease our risk of developing certain degenerative diseases such as cancer and premature aging. In addition, anyone undergoing radiation or chemotherapy should supplement their diet with garlic. “Based on a number of studies conducted by research teams from throughout the world, scientists have concluded that part of the preventive effect of garlic against cancer is due to protection against free radical damage. But that protection extended beyond the mere ability to protect against disease. The ability of garlic to protect against free radical damage may have yet another important benefit to cancer victims: it can, according to several published articles, protect against the damage that results from radiation treatment and chemotherapy commonly given to many cancer patients.” 44 Garlic also contains a number of amino acids which are required for the formation of an enzymatic antidote to free radical pathology which is created by cigarette smoke and other pollutants. Cysteine, glutamine, isoleucine and methionine found in garlic help to protect the cells from free radical damage. Garlic works as an antioxidant the same way that onions, and green chilies do. In his book The Miracle of Garlic, Paavo Airola states: “An Indian study showed that garlic exhibited a high antiox idant property as determined by the peroxide values of the products by the swift stability test. Garlic restrained the development of all characteristic indexes of rancidity (acids, peroxides, iodine no. etc.). Garlic retained its antioxidant property for a half year after harvesting.”45 Because our food, air, water and environments are heavily contaminated with pollutants of all kind including food additives, preservatives, artificial colorings, flavorings, sweeteners, chemical fertilizers, etc., garlic should become a permanent addition to our nutritional array of supplements.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=440) Anti-Aging Nutrients
Date:
June 18, 2005 09:07 AM
Anti-Aging Nutrients by Edward C. Wallace, DC, ND Energy Times, February 3, 2000 What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful, easy feeling. How Do We Age? Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD. The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress. Programmed Cell Theory In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing. Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging. Free Radical/Oxidative Stress Theory The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain. On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents. Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution. Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster. DNA Repair Theory Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die. What Can We Do? The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging. In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function." Antioxidant Protection Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit. Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.) Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency. In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725). Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly. Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens. Nutrition Deficiencies A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15). When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993). A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage. Longevity Diets A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460). Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers (Epidemiology 3[5], 1992: 389-391). Staying Alive Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines. Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63). In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat. Longevity and Exercise Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer. Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184). In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams. The Treadmill of Life The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying (JAMA 273 [14], April 12, 1995: 1093-1098). Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk. Longevity Supplementation Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging. Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways. Toning Down Enzymes Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls. In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154). In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies. The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552). Vitamins E & C A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial. Chronological Age Vs.Biological Age Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems. In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C. Similar Relationship A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less. And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons. The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988). Carotenoids When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene. Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119[1], Jan. 1989: 112-115). Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered. Flavonoids Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs. For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system. Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54). Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds. Amino Acid Health Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68). As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too. Attitude & Behavior Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit. In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15). In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14). Longevity at Last While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of longer life. And by staying healthier, your old age will be more enjoyable, too.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=377) Defeat Depression
Date:
June 13, 2005 01:18 PM
Defeat Depression by Cal Orey Energy Times, August 2, 1999 Depression plagues the creative and the mundane. The disparate desperate driven to distress by depression include painters, poets, actors and musicians as well as truck drivers, clerks, electricians and physicists. The victim list encompasses Vincent van Gogh, Emily Dickinson, Audrey Hepburn, Virginia Woolf and Ludwig von Beethoven, as well as millions of other sharers of melancholy misery. More than 17 million American men and women experience depression in one form or another every year, according to the National Mental Health Association (NMHA) in Alexandria, Virginia. This includes the deeply destructive major, or clinical, depression, the wide mood swings of bipolar disorder (manic-depressive illness), and dysthymia, a milder, long-lasting form of emotional suffering. Twice as Many Women In the depression scenario, women suffer twice as much: Two times as many women as men endure clinical depression, reports the NMHA. The mood-deteriorating effects of the hormonal disruptions women are heir to may be partly to blame. According to the National Institute of Mental Health (NIMH), about one of 10 Americans wades through at least one depressive swamp sometime during his or her life. The good news: Research shows that diet and lifestyle can lower your risk of depression. Birth of the Blues Nowadays, mounting evidence suggests that depression may result more from physiological factors than psychological woes. Some of the hidden reasons why you may be depressed include: nutritional deficiencies, exacerbated by overdosing on too much caffeine, sugar, alcohol and high fat foods; allergies; anxiety and chronic stress; and a chemical imbalance in the brain's gray matter. According to the NMHA, people with depression often possess too little or too large a quantity of the neurotransmitters norepinephrine, serotonin and dopamine. Changes in levels of these brain chemicals may cause, or contribute to, clinical depression. The NMHA also reports that an imbalance of melatonin, a chemical made by the body's pineal gland (located at the base of the brain), contributes to a form of wintertime depression called seasonal affective disorder (SAD). This hormone is made at increased levels in the dark. Therefore, the body may oversupply this hormone during winter's shortened daylight hours. Plan B Since the B vitamins are often involved in the production of energy, and a large component of depression may encompass the inability to get out of bed and deal with the world, experts believe that at least some of the signs of depression are linked to B deficiencies. For instance, studies cited in the Encyclopedia of Natural Medicine (Prima) by Michael Murray, ND and Joseph Pizzorno, ND, demonstrate that folate deficiency and lack of vitamin B12 can compromise mental health (Drugs 45, 1993: 623-36; Lancet 336, 1990: 392-5). Inositol: This vitamin is also part of the B vitamin complex, and it, too, has shown its ability to lift spirits. Research work in Israel shows that daily inositol given to 28 depressed patients for four weeks produced an overall positive effect. (Eur Neuropsychopharmacol 7:2, May 1997: 147-55). Inositol is found in whole, unprocessed grains, citrus fruits (except lemons) and brewer's yeast. NADH: Allan Magaziner, DO, in his book The Idiot's Complete Guide To Living Longer & Healthier (Alpha), reports that brain energizing NADH, a metabolite of vitamin B3, enhances the production of the key neurotransmitters dopamine, noradrenaline and serotonin. "In a recent clinical trial," he claims, "nearly all patients given NADH for depression reported improvement in their symptoms and the absence of side effects or adverse reactions." Moody Spotlight Another substance winning the spotlight for its effect on mood is SAM-e: S-adenosylmethionine. In New York on February 24, a symposium coordinated by the American Health Foundation met to hear researchers present information from studies of SAM-e's ability to possibly ease depression. "SAM-e is a natural product. You and I have it but as people age it declines in production in the body. And that's why we believe supplementation in older people is a beneficial means of bringing that back up and helping people that have depression," said the lead symposium researcher, John H. Weisburger, PhD, MD, Director Emeritus, American Health Foundation in Valhalla, New York. Another researcher, Teodoro Bottiglieri, PhD, Associate Professor of Biomedical Studies and Neurology, Director of Neuropharmacology at Baylor University reported: "SAM-e has been shown to enhance brain dopamine and serotonin neurotransmitter metabolism and receptor function. It may also aid in the repair of myelin that surrounds nerve cells. These mechanisms are likely to be responsible for the antidepressant effect of SAM-e." (Bottiglieri is co-author with Richard Brown, MD, and Carol Colman of Stop Depression Now, a report on the powers of SAM-e just published by G.P. Putnam's Sons.) SAM-e was first touted as an antidepressant in Italy in 1973. It's been reported that nearly 40 clinical trials demonstrate its beneficial effects as a natural antidepressant. For instance, an analysis of more than 1000 people suffering depression showed that the effect of antidepressants in patients taking SAM-e was 17% to 38% better than dummy preparations. Conventional antidepressants show a 20% effectiveness rate (Bressa G. Acta Neurol Scand S154, 1994: 7-14). 5-HTP: Another popular supplement to boost mood and relieve depression is hydroxytryptophan. "This medication is actually a brain chemical that is metabolized from tryptophan into serotonin," says Magaziner. And since low serotonin levels have been linked with depression, and certain prescribed medications may up serotonin levels, 5-HTP is in demand. "One of the more impressive studies supporting the efficacy of 5-HTP for depression evaluated 100 people who had previously found conventional antidepressant therapy to be inadequate. Forty-three of these folks reported a complete recovery, and eight showed significant improvement," reports Magaziner. Not only has 5-HTP been shown to work slightly better than drugs known as SSRIs (these include Prozac), he adds, it has fewer side effects than standard antidepressants, too. DHEA: Medical experts also believe that levels of the hormone DHEA (dehydroepiandrosterone) may influence mood. Ray Sahelian, MD, in his book All About DHEA (Avery) reports an interesting study conducted by Dr. Owen Wolkowitz of the Department of Psychiatry, University of California, San Francisco. A group of six depressed middle-aged and elderly individuals who took DHEA found that within a month they had better memory and mood. (Biological Psychiatry 41, 1997: 311-18.) "In addition," adds Sahelian, "other studies have also found that DHEA increases energy levels and a sense of well being." But follow package directions: Some people complain of greater irritability and overstimulation with DHEA, when they take large amounts. Herbal Relief St. John's wort: still the most touted natural therapy for defeating depression. In Europe, 23 clinical studies, reviewed in the August 3, 1996 British Medical Journal, found that this herb, also known as Hypericum perforatum, can be helpful in alleviating cases of mild to moderate depression. The work, which included 757 patients, has shown that hypericum produced fewer side effects than conventional anti-depressants. Although experts have never satisfactorily explained exactly how St. John's wort benefits the brain, some theorize that it boosts serotonin levels. And it can help SAD sufferers. "In a recent study of 20 people with SAD, four weeks' worth of St. John's wort significantly alleviated feelings of depression. Those people who added full-spectrum lights to the treatment program gained an even greater benefit," notes Dr. Magaziner. Valerian: Anxiety and stress, which can cause depression and insomnia, may be helped by this herb, says the prolific Dr. Sahelian in his book Kava: The Miracle Antianxiety Herb (St. Martin's). In 101 Medicinal Herbs (Interweave), Steven Foster reports that "Ten controlled clinical studies have been published on valerian...one of which suggests that valerian should be used for two to four weeks before daily mood and sleep patterns improve." Amino Acid Help Amino acids, the building blocks of protein, may also help improve mood. (For more on protein, see page 65.) These chemicals are used by the body to construct neurotransmitters, brain chemicals that facilitate mental activity. For instance, the amino acid L-tyrosine is necessary for the formation of transmitters adrenaline and dopamine. This substance, therefore, is given to alleviate depression and anxiety. The substance L-dopa which is given to victims of Parkinson's disease is concocted from tyrosine. And several antidepressants alleviate bad moods by boosting the interaction of brain chemicals related to tyrosine. In addition, since tyrosine is used to make adrenaline, this amino acid may be helpful for folks trying to cope with the mood problems related to stress. Another amino acid that experts believe useful for better moods, L-methionine, is used by the body to make choline, a crucial substance for brain function. (Choline goes into the formation of acetylcholine, a neurotransmitter.) Methionine has been given to people suffering from schizophrenia and depression as well as to those with Parkinson's. Methionine plays a number of crucial roles in the brain and body since it helps form other vital proteins. Depressive Smoking For those concerned about preserving a positive mood, researchers are positive that smoking worsens depression. A study at the Department of Behavioral Services at the Henry Ford Health System in Michigan found that daily smokers run twice the risk for major depression compared to those who only smoked occasionally. Unfortunately, the investigators found that not only did smoking seem to lead to depression, depression, in turn, led to more smoking (Archives of General Psychiatry, 2/99). "Smokers who have depression tend to see their smoking become a daily habit and it may be because they use nicotine to medicate their depressed mood," reported Naomi Breslau, PhD, who headed the research. Over a five year period, the researchers looked at about a thousand young people aged 21 to 30. They found that daily smokers generally start smoking in adolescence, and those who report early depression are three times as likely to eventually become daily smokers. If you're feeling down, don't give up hope. Although depression can prove to be a depressingly complicated malady, daily, healthy habits can offset its effects. Getting consistent exercise, dousing your cigarettes and turning to herbal and nutritional help to treat mild depression may defeat those blues.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=329) Power Protein
Date:
June 11, 2005 05:04 PM
Power Protein by Joanne Gallo Energy Times, August 4, 1999 Chances are, if you've been trying to lose weight, build muscle, or increase your energy levels, then you've been hearing about protein. This essential nutrient has stolen the spotlight of the health industry as the alleged key to vitality and a solid physique. With books like Protein Power (Bantam) and Dr. Atkins' New Diet Revolution (Avon) firmly implanted on The New York Times bestseller list, and protein bars and shakes growing in popularity, more people than ever are seeking to tap into the power of protein. But before you go on an all-out protein-blitz, how can you decide what's best for you? The Purpose of Protein No doubt about it, protein performs a variety of roles. First and foremost, it is used to manufacture and repair all of the body's cells and tissues, and forms muscles, skin, bones and hair. Protein makes up the connective tissue that forms the matrix of bones; keratin is a type of protein used to make hair and nails. It is essential to all metabolic processes; digestive enzymes and metabolism-regulating hormones (such as insulin, which influences blood sugar levels) are all made of protein. This nutrient also intricately takes part in transport functions: Without sufficient protein the body cannot produce adequate hemoglobin, which carries nutrients through the blood. Lipo-proteins are fat-carrying proteins which transport cholesterol through the bloodstream. Protein helps regulate fluid and electrolyte balance, maintaining proper blood volume. Immunoglobulins and antibodies that ward off diseases are also comprised of protein. Any protein that you eat that is not utilized for these purposes is stored as fat, although some may be broken down, converted to glucose and burned for energy. This can occur during intensive workouts, or when the body runs out of carbohydrates from the diet or glycogen from its muscle and liver stores. "Even though the body can depend on the fat it has stored, it still uses muscle protein, unless it is fed protein as food," explain Daniel Gastelu, MS, MFS, and Fred Hatfield, PhD, in their book Dynamic Nutrition for Maximum Performance (Avery). "When dietary circumstances cause the body to use amino acids as a source of energy, it cannot also use these amino acids for building muscle tissue or for performing their other metabolic functions." One can see why it is so important to eat a sufficient amount of protein daily in food, shakes or bars. Without it, bone tends to break down, the immune system can become impaired, and muscle strength drops as the body uses up muscle protein for energy. Acid Trip Proteins are built of chains of amino acids, and 20 different kinds of these building blocks are necessary for protein synthesis within the body. Eleven of them can be manufactured by the body through a process called de novo synthesis; these are referred to as non-essential amino acids. The other nine, which must be obtained from the diet, are known as essential amino acids. (Although some amino acids are called "non-essential," in actuality they are vital: The body needs all 20 amino acids to function properly.) Some of the more familiar non-essential amino acids include: n Carnitine helps remove fat from the bloodstream n Arginine helps burn sugar Essential amino acids include: n L-tryptophan, a precursor of the neurotransmitter serotonin, helps create calm moods and sleep patterns n L-lysine, required for the metabolism of fats n L-methionine a component of SAM-e (a supplement intended to relieve depression and arthritis, see p. 45) The body forms and destroys protein from amino acids in a constant cycle of synthesis and degradation. You must consume protein regularly to replace the lost amino acids that are oxidized when protein is broken down and used for fuel. The amount of amino acids lost each day depends on what you eat and how much exercise you do. Athletes vs. Weekend Warriors Protein intake in the general population is still adequate, notes Gail Butterfield, PhD, RD, director of Sports Nutrition at Stanford University Medical School. "But we're learning that what is true for the general population may not be true for the athletic population," she says. "With heavy training there is greater protein degradation and you need to increase your intake. Thus, protein requirements are higher for athletes than regular people." Also, if you diet or restrict your eating in any way, you may also not be getting enough protein. Certainly, if you work out, eating protein is important. Providing four calories of energy per gram, protein keeps blood sugar steady during exercise. After exercise, it helps replenish and maintain stores of glycogen (stored muscle fuel) and decreases the loss of amino acids, as recent research has shown (J Appl Physiol 81 (5), Nov. 1996: 2095-2104). Lab studies in animals show that protein consumed after you run, lift weights, bike, etc..., helps stimulate muscle growth (Jrnl of Nut 127 [6], June 1997: 1156-1159) High-protein diets are frequently touted to promote weight loss and increased energy. One of the most influential: the so-called 40-30-30 formula, developed by Barry Sears in his book The Zone: A Dietary Roadmap (HarperCollins), which describes a diet whose calories are 40% carbohydrates, 30% protein and 30% fat. The rationale: when you eat too many carbohydrates, your body uses these starches for energy instead of burning body fat. A high protein diet is supposed to keep your blood sugar balanced and stimulate hormones that burn body fat instead of carbohydrates for energy. Other fitness experts such as Sherri Kwasnicki, IDEA International Personal Trainer of the Year of 1998, say that while protein is a necessary component of any diet, extreme high-protein plans aren't necessary for recreational fitness buffs. However, she notes that maintaining muscle mass is the key to aging gracefully, and getting enough protein is critical for that. Protein Sources Many people today won't eat meat and dairy for ethical reasons, or to avoid the antibiotics and other chemicals in the raising of poultry and cattle. But that doesn't have to prohibit adequate protein intake. All soybean products, including tofu and soymilk, provide complete proteins, which supply ample quantities of all the essential amino acids. Vegan Power In the past vegetarians were told to combine particular foods to make sure they consumed all the essential amino acids at each meal. (For example, beans with either brown rice, corn, nuts, seeds or wheat forms "complete" protein.) Today, diet experts aren't so picky. Eating a variety of plant-based foods throughout the day is just as effective as combining them at one meal. Vegans who avoid all animal products should eat two servings at sometime during the day of plant-based protein sources, such as tofu, soy products, legumes, seeds and nuts. Protein On-The-Go The newest sources of protein are bars and shakes, which are growing steadily in popularity. Protein bars now constitute about 12% of the so-called energy bar market, with sales increasing about 38% per year. These bars generally provide at least 20 grams of protein, including soy and whey protein and calcium caseinate (milk protein). The benefits: bars supply protein along with carbohydrates for energy; protein powders, on the other hand, provide quickly digested, easily absorbed amino acids. Edmund Burke, PhD, author of Optimal Muscle Recovery (Avery), suggests "If you need extra protein, you may benefit from the convenience of a mixed carbohydrate-protein supplement... choose a supplement that's healthy and low in fat." Amino acid supplements are also growing in popularity, reported to build muscle and burn fat, or improve mood by boosting brain neurotransmitters. The amino acids glutamine, phenylalanine, tyrosine and 5-HTP (a form of tryptophan) are all used to boost spirits and enhance brain function. And if you still ponder the merits of those high protein diets, do keep in mind that protein may be better at controlling hunger than carbohydrates or fat since it steadies blood sugar, so it may help you stick to a reduced-calorie plan. But excess protein can't be stored as protein in the body: It is either burned for energy or converted to fat. And carbs are still the body's top energy source, so forgoing too many can leave you tired and sluggish. Still, with so many vital functions-and a variety of sources to choose from-you can't afford to not explore the benefits of protein.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=293) Nutrients for Longevity
Date:
June 10, 2005 09:59 PM
Nutrients for Longevity by Edward C. Wallace, ND, DC Energy Times, September 1, 1999 What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful easy feeling. How Do We Age Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD. The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress. Programmed Cell Theory In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing. Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging. Free Radical/Oxidative Stress Theory The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain. On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents. Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution. Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster. DNA Repair Theory Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die. What Can We Do The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging. In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function." Antioxidant Protection Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit. Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.) Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency. In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725). Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly. Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens. Nutrition Deficiencies A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15). When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993). A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage. Longevity Diets A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460) Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers. (Epidemiology 3[5], 1992: 389-391). Staying Alive Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines. Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects. (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63). In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat. Longevity and Exercise: Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer. Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184). In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams. The Treadmill of Life The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying. (JAMA 273 [14], April 12, 1995: 1093-1098). Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk. Longevity Supplementation Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging. Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways. Toning Down Enzymes Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls. In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154). In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies. The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552). Vitamins E & C A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial. Chronological Age Vs. Biological Age Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems. In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C. Similar Relationship A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less. And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons. The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988). Carotenoids When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene. Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119(1), Jan. 1989: 112-115). Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered. Flavonoids Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs. For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system. Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54). Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds. Amino Acid Health Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68). As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too. Attitude & Behavior Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit. In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15). In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14). Longevity at Last While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of living longer. An added benefit: By staying healthier, your old age won't only be longer, it will be more enjoyable, too. And, who knows, if you hang around long enough, taking your nutrients and getting a comfortable amount of consistent exercise, while meditating and refusing to succumb to stress, that magic bullet that will keep you alive for centuries may be discovered. Some day a new antioxidant or other substance may finally prove to provide the elusive fountain of youth. Stay tuned.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=283) Basic Detox
Date:
June 10, 2005 04:08 PM
Basic Detox by Harriet Epstein , February 4, 2002 Basic Detox By Harriet Epstein Trying to stay healthy and clean in a dirty world can prove a difficult task. The rise of modern industry and agriculture has meant the widespread accumulation of toxins in our environment that can cause health problems. As Kenneth Bock, MD, and Nellie Sabin point out in their book The Road to Immunity (Pocket), "Fat soluble chemicals are readily absorbed by the body but are difficult to excrete. To be excreted, they must first be enzymatically converted into water-soluble substances. Some of them can't be converted at all." Bock and Sabin point out that a 1990 survey by the United States Environmental Protection Agency (EPA) that looked at people's tissues found that everyone the agency examined had styrene (a chemical used to make plastic) and xylene (a paint and gasoline solvent) stored in their bodyfat. Toxin Exposure The toxins that you encounter every day are not only present in air and water, but also may be found in food and medicines. If we eat beef that's been exposed to pesticides, those chemicals may be shunted into our bodyfat. Pesticide residues in fruits and vegetables may end up in a similar place. To cope with chemicals, the human body has evolved methods for detoxifying. When we breathe out we often release inhaled toxins. Other toxins are purged through urine, feces and sweat. One of the chief organs responsible for cleansing the body is the liver. This organ utilizes a pair of chemical pathways for breaking down and eliminating toxins. In our hectic, industrialized world, this flow of toxins can overwhelm the liver's ability to detoxify. In addition, the dual processes the liver uses to eliminate noxious substances may become unbalanced, allowing toxins produced by one pathway to build up to dangerous proportions. Languishing Liver Once liver function falters, toxic havoc ensues. Toxins may remain in the body, often stored indefinitely in bodyfat. The body's detoxifying systems may be swamped with toxins. In protecting the liver and enhancing its detox functions, many naturopathic practitioners recommend the herb milk thistle (silybum marianum). According to Steven Bratman, MD, and David Kroll, PhD, authors of the Natural Health Bible (Prima), milk thistle helps the liver cope with its toxic load. Consequently, milk thistle is frequently used in Europe for liver problems like jaundice. Bratman and Kroll point out that milk thistle "is one of the few herbs that have no real equivalent in the world of conventional medicine." As Lise Alschuler, ND, medical director at the Bastyr Natural Health Clinic, told Natural Digest, "Milk thistle protects the liver against toxic damage (and) helps prevent damage to the rest of the body." Toxin Zappers The compounds in milk thistle that help zap toxins, known as silymarin, protect the liver by binding with substances that would otherwise interact with the liver and slow its function. They also help the liver repair itself and regenerate new liver cells. As an extra bonus, silymarin acts as an antioxidant, protecting liver cell membranes from oxidative damage. Dandy Detox Dandelion has a place as another traditional treatment for toning the liver and boosting the body's filtration system. The leaves are a cornucopia of antioxidants and nutrients including B vitamins, vitamins A, C and D, plus boron, silicon, potassium, magnesium and zinc. They help detoxify by acting as a mild diuretic: they cause the body to eliminate excess fluid. But herbalists worldwide have found the compounds in dandelion root most useful for helping alleviate liver and gall bladder malfunction. (If you think you suffer these difficulties, consult your health practitioner.) Two unique and helpful natural substances found in dandelion root are chemicals called germacranolide and eudesmanolide. The root, according to the Natural Health Bible, has traditionally been used to speed up a sluggish or congested liver as well as detoxing the body by eliminating constipation. Research indicates dandelion root may stimulate bile flow (Arzneimittel -forschung 9, 1959: 376-378). Juniper berries (Juniperus communis), may also be taken with dandelion as a diuretic. This botanical, often used to combat urinary tract problems, is also an anti-inflammatory (Phyto Res 1, 1997: 28-31). Metal Problems Heavy metals rank as dangerous toxins unleashed by modern industry. As Michael Murray, ND, and Joseph Pizzorno, ND, explain in the Encyclopedia of Natural Medicine (Prima), metals like lead, mercury, cadmium, arsenic, nickel and aluminum can "accumulate within the (body) where they can severely disrupt normal function." Public health experts estimate at least one in five Americans has been a victim of heavy metal poisoning. Lead may be the most common villain. In your everyday life, you may be ingesting metals from your cookware, from pesticides, cigarette smoke, dental fillings, polluted fish, and chipping house paint. Signs that you may suffer from toxicity linked to heavy metals: Unusual fatigue, Persistent headaches, Unexplained muscle pains, Anemia, Ringing in the ears or dizziness and Tremors. Of course, if you think you suffer from heavy metal poisoning, you should see a knowledgeable health practitioner as soon as possible. Murray and Pizzorno recommend an array of precautions to protect yourself against heavy metals in the environment: Take a daily multivitamin and mineral. Take extra amounts of vitamin C and B-complex. Take amino acids that contain sulfur (taurine, cysteine and methionine) and high sulfur foods like onions and garlic (or supplements). (Consult your pharmacist of health practitioner before taking individual amino acids.) Consume water-soluble fibers like guar gum, oat bran, psyllium and pectin. Smooth Digestion In addition, Leo Galland, MD, in his book The Four Pillars of Healing (Random House) offers these tips for keeping your digestive tract functioning at top capacity: Add spices to your foods and consume garlic, onion, turmeric, rosemary and sage to aid digestion. Take supplements of lactobacil-lus acidophilus and lactobacillus plantarum, friendly bacteria that in-habit the large intestine. These microorganisms can help break down toxins and eliminate them. Use aspirin and ibuprofen as little as possible. They increase the permeability of the digestive system, allowing allergens and other problematic substances to enter the body. Do not use antacids. The stomach's acidic environment is designed to kill ingested bacteria and parasites. To fight digestive problems or heartburn, cut back on saturated fat; eat smaller meals. Chewing on calcium tablets after meals may help. Foods that can exacerbate heartburn include coffee, alcoholic beverages and very spicy foods. Dr. Galland also recommends not eating for four hours before bed. Environmental Free Radicals Detoxing the body may also require taking antioxidant nutrients to fight off what are called free radicals. Free radicals are caustic molecues thought to be involved in causing many chronic problems such as cancer and heart disease. Free radicals are created within the body and its cells every time a metabolic activity takes place. While the human body has developed its own mechanisms for defending itself against these byproducts of metabolism, exposure to pollution, radiation and other toxins may overburden the body's free radical burden. Scientists believe that taking extra antioxidant nutrients like vitamins C and E and carotenoids (natural substances found in many vegetarian foods) may help prevent damage by free radicals. Environmental oxidizing agents include ionizing radiation (from industry, sun, cosmic rays, x-rays) ozone and nitrous oxide (from auto exhaust) heavy metals (mercury, cadmium, lead) and cigarette smoke, along with other chemical and compounds from food, water and air. Free radicals are believed to play a role in more than sixty different health conditions, including the aging process, cancer and arteriosclerosis. (Proc Natl Acad Sci USA 1993;90:7915-7922). The good news? Reducing exposure to free radicals and increasing intake of antioxidant nutrients can shrink the risk of these health problems. Antioxidant focus "Antioxidants can't get rid of heavy metals and solvents," says Dr. Glidden, "but they do cut down on the damage they do while they're there. As toxins wander through your body, they generate metabolic reactions, resulting in free radicals. And anti-oxidants mop them up." The liver is the last line of defense in handling toxins; supplements help it regenerate itself. The body itself does produce enzymes like Superoxide dismutase (SOD) catalase, and glutathione peroxidase which can defend against and defuse many types of free radicals. Supplements of these compounds are also available to augment the body's supply. These building block nutrients include the minerals manganese, zinc, and copper for SOD and selenium for glutathione peroxidase. Many vitamins and minerals act as antioxidants. Dr. Crinnion recommends a multivitamin with "a lot of B, especially magnesium." Since chlorinated pesticides like DDT "rob the body" of B1 and Vitamin A, he says, it's a good idea to supplement these as well. In addition, acidophilus, a beneficial bacteria that grows in the digestive tract (and found in yogurt) may restore immunity hurt by pollutants. A study on women with recurrent vaginal candidiasis found that acidophilus cut their infections by 300% (Annals Int Med 1992; 116:353-357.) Another immunity enhancer, colostrum, a natural immune enhancer that promotes cellular repair (Food Res Intl. 1995, 28(1):9-16) can also help the immune system battle pollution. Vitamin C vs Pollution A study of vitamin's C's antioxidant properties, conducted by University of Buffalo epidemiologists, and presented at the Annual Meeting of the Society of Epidemiologic Research, revealed that people with higher levels of vitamin C in their blood serum have lower levels of a marker of oxidative stress. "It is well known that oxidative stress (cell damage caused by free radicals) plays a role in arteriosclerosis, cancer, pulmonary disease and other chronic conditions," said Holger Schunemann, M.D. a research assistant professor of social and preventive medicine at the University of Buffalo and lead author on the study. "In this population, vitamin C was negatively associated with oxidative stress, suggesting it may play a role in protecting against these diseases." Vitamin C is the "greatest antioxidant," says Dr. Crinnion. "It has even been shown to clear lead from the blood." Effective E A powerful fat-soluble antioxidant, Vitamin E scavenges free radicals protecting cells from oxidative damage. Vitamin E, "reverses toxicity of various toxic chemicals," says Dr. Walter Crinnion, "it is also a stabilizer of membranes." A study published in the American Journal of Clinical Nutrition regarding antioxidant vitamin supplementation and lipid peroxidation in smokers even indicates that an antioxidant-supplemented drink can reduce lipid peroxidation and susceptibility of LDL to oxidation in smokers and may ameliorate the oxidative stress of cigarette smoke. Dr. Glidden recommends E preferably in the form of mixed tocopherols )If you take blood thinners, check with your health practitioner.) Unfortunately, completely avoiding toxins in today's world is probably impossible. Civilization and toxic chemicals accompany each other hand in rubber-glove-encased hand. Still, with proper attention to nutrition and supplements to keep our bodies detoxifying, we can probably minimize health difficulties linked to these undesirables.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=275) The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease
Date:
June 09, 2005 05:22 PM
The Latest Breakthroughs in Garlic Research on Cancer and Cardiovascular Disease Presented at the 2005 World Garlic Symposium
Many of the world’s top-level scientists gathered in Washington D.C. this week for the 2005 Garlic Symposium, entitled, “Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease.” The conference provided current scientific information about the effect of garlic and its constituents on health and performance. The symposium was held at the Georgetown University Conference Center on April 9-11, 2005. “For the first time in seven years authorities in various fields of garlic research from all over the world to provide the latest updates, specifically regarding aged garlic extract and its actions in diseased states including heart disease and cancer,” commented Dr. Matthew Budoff, M.D. cardiovascular researcher at UCLA. “Garlic has been used medicinally for thousands of years in virtually all ancient cultures. Now, new metabolic roles for garlic are being proposed and there are many promising lines of research.” Presentation highlights included:
Effect of aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study that determined that the atherosclerotic plaque burden detected by electron beam tomography (EBT) changed significantly with the use of aged garlic extract, Patients in Dr. Budoff’s study were able to significantly lower their total cholesterol, blood pressure, homocysteine and LDL cholesterol oxidation levels with aged garlic extract supplementation.
“Garlic is turning out to be a major player in cancer and heart disease prevention and control, especially in combination with drug treatments,” said Richard Rivlin, M.D. of Strang Cancer Prevention Center at Cornell. “It’s also showing us that we can start early. It’s madness to treat cancer and heart disease in their advanced stages. We need to start early and aged garlic extract is an excellent way to do that.” Almost 400 scientific studies have been completed on aged garlic extract, done in major universities worldwide. These studies have focused on a variety of heart disease risk factors such as cholesterol, high blood pressure, homocysteine levels, inhibiting LDL oxidation, anti-platelet aggregation and adhesion, stimulating blood circulation; in addition to other studies on immune stimulation, cognitive effects, liver function and anti-tumor effects. . Abstracts PRECLINICAL PERSPECTIVE ON GARLIC AND CANCER. John A. Milner, National Cancer Institute, Rockville, MD 20892 Mounting evidence points to the anticancer properties of fresh garlic extracts, aged garlic, garlic oil, and a number of specific organosulfur compounds from garlic. These prevention characteristics arise through both a dose and temporal related change in several cellular events including those involving drug metabolism, immunocompetence, cell cycle regulation, apoptosis and angiogenesis. A block in carcinogen activation through modulation of cytochrome P450-dependent monooxygenases and/or acceleration of carcinogen detoxification via induction of phase II enzymes likely account for some of this protection. The block in preneoplastic lesions and/or tumors in several sites suggests a generalizable mechanism. The efficacy of water- and lipid-soluble allyl sulfur compounds against chemical carcinogenesis appears comparable, although more studies are needed. A shift in sulfhydryl groups, redox status or enzyme catalysis may account for some of the phenotypic changes. They may also account for the observed hyperphosphorylation of specific cell cycle related proteins and histone hyperacetylation; both of which have been correlated with suppressed tumor cell proliferation. Several forms of allyl sulfur compounds are effective in blocking cell division and inducing apoptosis, but notable differences in the efficacy among these various compounds and across tumor types are evident. While the expression of many genes and proteins can be influenced by allyl sulfides; the challenge is to determine which is responsible for a phenotypic change. Additional studies are needed with more modest exposures and over prolonged periods and that utilize transgenic and knockout models to assist in the identification of molecular targets. Finally, additional research is needed to identify sensitive “effect” and “susceptibility” biomarkers that can ultimately be used to identify responders from non-responders. INHIBITION OF CORONARY ARTERIAL PLAQUE ACCUMULATION BY GARLIC. Matthew Budoff, Harbor-UCLA Medical Center, UCLA School of Medicine, California, USA Effect of Aged garlic extract (AGE) has been tested in the placebo-controlled double blind randomized clinical study to determine whether the atherosclerotic plaque burden detected by electron beam tomography (EBT) will change at a different rate under the influence of AGE or placebo. EBT can non-invasively quantitate the amount of coronary calcification and track atherosclerotic plaque over time. Nineteen of 23 patients completed the study protocol. The patients were well matched for age, gender, statin use and cardiac risk factors. Patients underwent EBT and blood testing at baseline, and then again after 12 months of randomization. The average change in the calcium score (Volumetric method) ± SD for the AGE group (n = 9) was 7.5 ± 9.4% over the one year. The placebo group (n = 10) demonstrated 22.2 ± 18.5% annual progression, significantly greater than the treated cohort (p = 0.01). While there were no significant changes in cholesterol parameters, or C Reactive protein between the groups, high density lipoproteins and plasma homocysteine in the AGE group demonstrated a trend toward improvement compared to the placebo patients. Thus, although this is a small-scale trial, it demonstrates the potential of AGE to inhibit the rate of atherosclerosis (progression of coronary calcium), as compared to placebo over one year. Larger studies need to be performed to assess this potential anti-atherosclerotic therapy and the impact on coronary events. INFLUENCE OF GARLIC ON ENDOTHELIAL DYSFUNCTION IN HYPERHOMOCYSTEINEMIA. N. Weiss, N. Ide, T. Abahji, L. Nill, C. Keller, U. Hoffmann. Klinikum der Universität München, D-80336 Munich, Germany Endothelial dysfunction (ED) due to decreased bioavailable nitric oxide (NO) by increased vascular oxidant stress plays a critical role in the vascular pathobiology of hyperhomocysteinemia (hhcy). Aged Garlic Extract (AGE) minimizes intracellular oxidant stress and stimulates NO generation in endothelial cells. We performed a placebo-controlled, blinded, cross-over study to examine whether AGE prevents macro- and microvascular ED during acute hhcy induced by an oral methionine challenge in healthy subjects. Acute hhcy leads to a significant decrease in flow-mediated vasodilation of the brachial artery as determined by vascular ultrasound, indicative of macrovascular ED, as well as a decreased number of recruited nailfold capillaries during postischemic reactive hyperemia as determined by videomicroscopy, and to a decreased ratio of acetylcholine (endothelium-dependent) vs. sodium nitroprusside (endothelium-independent) iontophoresis induced skin perfusion as measured by laser doppler flowmetry, indicative of microvascular ED. Preliminary results show that pretreatment with AGE for six weeks diminishes the adverse effects of acute hhcy on endothelium-dependent brachial artery vasodilation and on acetylcholine-induced stimulation of skin perfusion. Whether or not this is accompanied by changes in biochemical parameters of ED is still under investigation. It is concluded that AGE may at least partly prevent a decrease in bioavailable NO during acute hhcy.
Bibliographies David Heber, MD, PhD, FACP, FACN Professor, UCLA Department of Medicine - Division of Clinical Nutrition, at the David Geffen School of Medicine, UCLA, and UCLA School of Public Health; Director, UCLA Center for Human Nutrition; Director, NIH Center for Dietary Supplement Research in Botanicals (CDSRB); Director, NCI-funded Clinical Nutrition Research Unit; Vice Chair, UCLA Collaborative Centers for Integrative Medicine; Member, UCLA's Jonsson Comprehensive Cancer Center Matthew Budoff, MD, FACC Matthew Budoff, MD, FACC, is an associate professor of medicine at the UCLA School of Medicine and program director for the Division of Cardiology, as well as director of the Electron Beam CT Laboratory at Harbor-UCLA Medical Center in Torrance, Calif. He completed his undergraduate work at University of California, Riverside, and earned his medical degree at George Washington University in Washington D.C. Dr. Budoff’s efforts to identify and modify risk factors for cardiovascular disease using electron beam CT have been extensively published. His latest research focuses on the progression of arteriosclerosis.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=257) SAMe - Supports Joint Comfort, Function and Mobility ...
Date:
June 06, 2005 08:30 AM
You’ve read about it in the media. Europeans have experienced its health benefits for two decades. Now consumers in the United States have access to a nutrient with groundbreaking potential. SAMe, a natural compound formed in our bodies from the amino acid methionine, is stirring excitement due to its wide-ranging health effects. SAMe plays a critical role in cartilage formation. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. SAMe has also been found to support a positive outlook. It affects the synthesis and activation of proteins such as mood-boosting neurotransmitters. Cutting-Edge Nutrition Technological advances have made possible the production of stable, bioavailable forms of a natural nutrient with broad-range potential. Source Naturals now offers you the fruits of that technology. A Multipurpose Nutrient SAMe, or S-adenosyl L-methionine, is formed when our bodies combine the amino acid L-methionine with ATP, the primary energy-carrying molecule in our cells. SAMe is a multipurpose nutrient, which is present in every living cell. Because SAMe is involved in so many vital processes, it is important that our bodies produce sufficient SAMe. However, SAMe levels tend to decline with age, and also can be affected by dietary imbalances. To produce adequate amounts, we need to consume not only methionine-containing protein foods, but also foods rich in vitamins B-6, B-12 and folic acid, which are needed to ensure the synthesis of SAMe. SAMe also is a highly unstable molecule. A lot of scientific research was needed to make it available as a supplement. Source Naturals has studied the research and offers this vital nutrient in a form your body can use. Methylation is the Key SAMe is known as a “methyl donor.” This means that it works by giving up a piece of itself (a methyl group consisting of one carbon and three hydrogen atoms) to other molecules. This methylation process affects the synthesis, activation and metabolism of various hormones, neurotransmitters, phospholipids, nucleic acids, proteins and other biological molecules. Methylation plays a part in many critical functions, including the maintenance of cell membranes, the removal of toxic substances from the body and the production of mood-boosting neurotransmitters such as dopamine and serotonin. Effective Joint Support SAMe has been used in Europe for two decades for joint support. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. SAMe is important in a process called transsulfuration. The breakdown of SAMe generates sulfate groups that help maintain joint cartilage. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage. Promotes Mental Well-Being Studies also show that SAMe helps support a positive outlook. Although the mechanism by which SAMe promotes mental well-being is not known, we do know it is able to cross the blood-brain barrier, where it affects the production of mood-boosting neurotransmitters. Clinically Researched Potency Source Naturals SAME is offered in the clinically researched potency of 400 mg per suggested daily use (two tablets). The tablets are enteric coated and blister packed to prevent breakdown and inactivation of ingredients. Source Naturals SAME is available in 20-tablet boxes.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=193) OptiZinc - The king of Zinc ...
Date:
June 04, 2005 10:43 AM
Source Naturals brings you yet another breakthrough in mineral nutrition: OptiZinc! Opti Zinc is Zinc Monomethionine — Zinc combined with the essential amino acid Methionine. It is FDA approved as safe for human nutrition, and is so unique, it’s patented. Opti Zinc — THE MOST POTENT FORM OF ZINC AVAILABLE Extensive scientific research shows that Opti Zinc is the most bioavailable and bioactive form of Zinc tested.1 Aside from demonstrating superior absorption and utilization by the body for Zinc’s many functions, Opti zinc is also more efficient than other forms of Zinc in getting needed Vitamin A out of storage in the liver, thus making it available for use.2 Perhaps most outstanding is the synergy offered by this combination of Zinc and Methionine: while both of these nutrients are well-known for their freeradical- neutralizing properties, the antioxidant activity of Opti Zinc far surpasses that of either Zinc or Methionine alone. ZINC — ESSENTIAL FOR YOUR HEALTH Zinc is one of the most important minerals your body uses. Among its many functions, Zinc is: ? critical for the health of the thymus gland, which is necessary for the natural defenses, as demonstrated in recent research by Nicola Fabris, Ph.D., director of the Gerontology Research Department of the Italian National Research Center on Aging in Ancona, Italy;3 DO YOU GET ENOUGH ZINC IN YOUR DIET? As vital as Zinc is, it can be hard to get enough of, even when following a healthy diet. Surveys show that the daily intake of Zinc in the average American diet ranges from 8 to 11 mg, yet the U.S. RDA is 15 mg. The few excellent sources include seafoods (such as oysters, herring, and clams), whole oatmeal, wheat germ, wheat bran, and milk.4 If some of these are not a regular part of your diet, you may be one of many people who are Zinc deficient, and you may want to use a dietary supplement. SOURCE NATURALS™ — Opti Zinc THE SUPPLEMENT OF CHOICE One Source Naturals’ Opti Zinc tablet provides 30 mg of Zinc (from 150 mg Opti Zinc Zinc Monomethionine), which is 200% of the U.S. RDA for Zinc. 300 mcg of the essential mineral Copper is also included, to offset the displacement of Copper that can occur when high levels of Zinc are consumed. The form of Copper used is also state-of-the-art: it is Copper Sebacate, a natural compound that is Copper:SOD-mimetic, meaning that even on its own, it can act as an antioxidant. Its inclusion with Zinc Monomethionine makes Source Naturals’ OptiZinc a powerful antioxidant combination that is truly on the cutting edge of nutrition science. OPTI ZINC® brand of Zinc Monomethionine complex is a trademark of InterHealth Company; U.S. Patents Nos. 3,941,818, 4,021,569, & 4,764,633. Source Naturals’ OPTI ZINC® is all-Vegetarian and hypoallergenic: contains no yeast, dairy, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.
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(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=182) MYELIN SHEATH SUPPORT™ - Herbal-Nutrient Nervous System Support!
Date:
June 04, 2005 10:15 AM
Planetary Formulas is pleased to introduce MYELIN SHEATH SUPPORT: a comprehensive formula designed to support the fat-like insulating sheath (myelin) that surrounds nerve tissues. Properly formed myelin is necessary for optimal nerve conduction. MYELIN SHEATH SUPPORT is the first formula developed for Planetary Formulas by herbalist and Ayurvedic specialist Alan Tillotson. It consists of some of the most highly regarded tonifiers of Chinese and Ayurvedic herbalism, along with additional key botanicals and supporting nutrients used with success in his practice. Nervous System Support MYELIN SHEATH SUPPORT is a broad-range herbal-nutrient formula that supports your nervous system with traditional Ayurvedic and Chinese botanicals as well as scientifically researched nutrients. Vitamin B-12 is key to the MYELIN SHEATH SUPPORT formula. It plays two critical roles: 1) it is essential for normal health of blood; and 2) it may function as a coenzyme in the synthesis of either the protein or lipid part of myelin. Comprehensive Botanical - Nutrient Formula Ayurvedic botanicals: Ashwagandha has been widely used throughout India for 3,000-4,000 years. It is one of the most highly regarded tonics in the 6,000-year old Ayurvedic tradition. Bacopa has been reported by Ayurvedic scholar Charaka to promote mental ability. Yogaraj guggul is one of the most valued botanical compounds of Ayurveda. The boswellic acids in boswellia inhibit leukotriene synthesis. Shilajit, a mineral resin that oozes from steep rocks in the Himalayas, is used extensively in Ayurveda. Curcuma (turmeric) has been used both internally and externally in Ayurveda. Curcuma is included in a dosage clinically shown to inhibit a group of enzymes that influence metabolism of arachidonic acid. Arachidonic acid is an unsaturated fatty acid found in most animal fats and is a precursor of prostaglandins. Chinese herbs: Included are the Chinese tonifiers panax ginseng and tienchi ginseng, as well as licorice extract (which is also prominent in European herbalism). MYELIN SHEATH SUPPORT delivers panax ginseng in amounts clinically shown to have adaptogenic (anti-stress) effects. Nutrients: Vitamin B-12, central for supporting the nervous system and specifically the myelin sheath, is included in the form of methylcobalamin. While a few forms of B-12 have been used clinically, it has been shown that methylcobalamin is a highly assimilable form of B-12, leading to increased retention in tissues. MYELIN SHEATH SUPPORT also includes zinc, copper, L-selenomethionine, boron, calcium, potassium, magnesium, chromium and pantothenic acid. New Formulator! Alan Tillotson is the newest member of the Planetary Formulas formulation team. He has been an ardent student of Ayurvedic herbalism, having engaged in an apprenticeship since 1976 with Ayurvedic scholar Mana Bajra Bajracharya, a practitioner whose family’s Ayurvedic lineage dates back 700 years. Planetary Formulas MYELIN SHEATH SUPPORT is available in bottles of 45, 90 and 180 tablets. Planetary Formulas: More than Herbs— Herbalism!
References
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=179) Muscle Mass - Reach Your Maximum Muscle Potential
Date:
June 04, 2005 09:49 AM
The serious athletes of today know how much it takes to fulfill their competitive goals: careful training, a strong will, and also the right kind of nutrition. Sports science now makes available key nutrients which help assure that strenuous workout regimes will show results. Results that are both nutritionally sound and dramatically visible, without the need for dangerous steroids or chemicals. MUSCLE MASS™ is such a state-of-the-art sports science formula. THE PURPOSE OF MUSCLE MASS ™ is to help translate distant goals for greater strength and power into quicker, awesome reality. It is the premier formula combining all essential nutrients known to maximize muscle development and optimize strength.
In sum, all these balanced, cutting-edge factors combine to assist you in meeting the challenges you’ve set for your body. Power, endurance, strength, tone, and the winner’s circle are now closer.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=177) MSM - Methylsulfonylmethane: Nature’s Source for Dietary Sulfur
Date:
June 04, 2005 09:42 AM
Sulfur is an important component of our body’s proteins. It is present in our hair, skin, nails and tendons, and plays a critical role in maintaining the integrity and elasticity of connective tissue. And now this vital nutrient can be obtained from a natural, bioavailable source. MSM, or methylsulfonylmethane, is a naturally occurring form of organic sulfur. Though present in dietary sources such as milk, eggs, fish, fruits, vegetables, grains and lean meat, MSM may be lost as a result of over-processing and heating – a particular problem in the modern diet. That’s why Source Naturals created MSM. Taking MSM throughout the day helps to replenish the body’s supply of assimilable sulfur. Sulfur Helps Maintain the Integrity of Connective Tissue Sulfur is found in proteins throughout our bodies and is vital to our connective tissues. It must be present in the body in correct balance to keep our tissues elastic and free. Sulfur in our bodies is a major constituent of the glycosaminoglycans, or GAGs. These large, spongy, waterholding molecules are long chains of amino sugars, including chondroitin sulfate. They form the gel-like matrix of the ground substance of our tissues, especially in connective tissue, such as tendons, cartilage, skin and bones. These “gels” are the glue that holds us together. Glycosaminoglycan chains fill most of the space between our cells, providing mechanical support to tissues while still allowing the diffusion of nutrients, metabolites and hormones between the blood and tissue cells. The gel-like matrix, together with its GAGs and structural and adhesive components (collagen and elastin), forms the architectural framework of the body. Dietary sulfur is related to the production of GAGs. This is especially important during growth and development, and when connective tissue metabolism becomes active for support of healthy tissues. Sulfur also is needed for amino acid metabolism and hormone synthesis, and is a key factor in the body’s natural defenses. It is a component of important sulfur amino acids, including methionine, cysteine and glutathione. Vitamin C for Additional Joint Support Source Naturals has added vitamin C to its MSM tablets because C also is crucial to connective tissue. Vitamin C was first identified as essential because of its role in preventing the classic deficiency disease, scurvy. Scurvy is the total breakdown of collagen, the connective protein that binds tissue together. Although scurvy is rare today, vitamin C still is associated with support for joint function. Over-Processing & the Modern Diet We should be able to get sufficient MSM from our diets. It is a naturally occurring form of organic sulfur found mainly in protein-rich foods, such as eggs, fish and lean meat. However, today’s over-processed American diet may provide low amounts of sulfur. In this situation, supplementation may be advisable. MSM: A Versatile Nutrient Because sulfur is vital to all our body tissues, MSM is a versatile nutrient with a wide range of uses. Source Naturals offers MSM in a 750 mg potency with 125 mg of vitamin C added per tablet. It is sold in 60, 120 and 240-tablet bottles. MSM also is available in a high-potency powder, in 4 oz and 8 oz containers.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=176) Life Minerals - Why are Minerals So Important?
Date:
June 02, 2005 01:14 PM
Why Are Minerals So Important? The value of adequate mineral intake for overall health cannot be overstated. Their effects are vast and broad; their deficiencies devastating. Minerals are components of body tissues and fluids that work in combination with enzymes, hormones, vitamins and transport substances. Minerals participate in nerve transmission, muscle contraction, cell permeability, tissue structure, blood formation, acid-base balance, fluid regulation, blood pressure control, protein metabolism and energy production. The human body requires large amounts of some minerals, and trace amounts of others, while some minerals – such as Lead, Mercury and Aluminum – are toxic to the body. Those minerals that are essential to health in relatively high amounts – Calcium, Phosphorus, Potassium, Sulphur, Sodium, Chlorine, and Magnesium – are called macrominerals. Trace minerals – Zinc, Manganese, Copper, Iron, Chromium, Selenium, Iodine and Molybdenum, to name a few – are those which are present in the body in minute amounts, but are just as essential to health as the major minerals. One of the main functions of minerals in the body is to activate enzymes. Magnesium, for example, activates over 300 different enzymes, while Zinc “turns on” over 100. Enzymes are catalysts, functioning in the cells to accelerate chemical reactions. All of these chemical reactions collectively are referred to as “metabolism”, which is the very basis of life. Why Do We Need Minerals Now More Than Ever?
What Is The Krebs’ Cycle? And What Are “Krebs’ Cycle Minerals”? The Krebs’ Cycle is the energetic root of life, taking place in every cell of the body. It produces 90% of the body’s total energy in the form of ATP. Krebs’ Cycle Minerals are those which are bound to the organic acids used in the Krebs’ Cycle. Such mineral complexes are increasingly becoming the standard in mineralinclusive supplements because they’re so good at what they do: Transport. They are especially effective at penetrating various cell membranes and organelle membranes, thus carrying their mineral partners inside the cell. Many of these organelles have membranes to keep out biochemical invaders; therefore, not just any substance can penetrate cells and their organelles. Source Naturals’ Life Minerals™: Optimal Mineral Supplementation All this technical and scientific information has been brought together by the experts at Source Naturals into one comprehensive multi-mineral formula: Life Minerals™. Many of the minerals in Life Minerals™ — Calcium, Magnesium, Potassium, Manganese and Iron — are bound to some of the best known transport agents in the body, the Krebs’ Cycle organic compounds. In addition, there are minerals not usually found in other mineral supplements, such as Silicon, Boron, Copper, and Molybdenum. Plus there are the Vitamins B6, C and D3, which have been shown to significantly enhance mineral absorption and utilization. In addition to the Krebs’ Cycle minerals, Life Minerals™ also uses superior forms of other minerals. The Zinc is OptiZinc™ Zinc Monomethionine, shown in scientific studies to be highly bioavailable, offering increased absorption. The Chromium is ChromeMate®, the non-yeast Glucose Tolerance Factor Chromium, believed by many to be the most superior form of Chromium. Copper Sebacate, a more bioavailable form of Copper, is also included. Minerals are crucial to both the structure and function of the body in hundreds of ways. But what good are mineral supplements if your body cannot utilize them to their fullest advantage? Supplementing your diet with Life Minerals™ is an important aid against deficiencies that may be more significant than suspected. By providing minerals with the highest bioavailability, and including significant potencies of each, Source Naturals’ Life Minerals is your best chance of reaping all the benefits that minerals have to offer.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=162) Joint Response and Ultra Joint Response
Date:
June 02, 2005 01:01 PM
Many people are unaware of the multiple body systems involved with joint health. Source Naturals ULTRA JOINT RESPONSE™ is a Bio-Aligned Formula™ that goes deep to bring alignment to these multiple systems. It features structural building blocks, tissue production cofactors, and ingredients that aid the body’s mechanisms for soothing relief and antioxidant defense. Joint Support Formulations You can use ULTRA JOINT RESPONSE alone or as the core of your healthy joints program, complementing it with additional potencies and ingredients. These include: GLUCOSAMINE CHONDROITIN WITH MSM™, MSM Cream, SAME, CM COMPLEX™ Cetyl Myristoleate, and BROMELAIN. For muscle discomfort and fatigue, Source Naturals also offers you FIBRO-RESPONSE™ Bio-Aligned Formula. ULTRA JOINT RESPONSE™: BIO-ALIGNED FORMULA ULTRA JOINT RESPONSE uses scientifically researched ingredients and nutritive co-factors for a comprehensive approach to soothing, lubricating, rebuilding and aligning connective tissue, joints, tendons and ligaments. MSM dietary sulfur, glucosamine and sea cucumber provide structural building blocks that are necessary to help maintain the integrity of joints and connective tissue. Vitamins A, B-6 and C, zinc, manganese, and copper act as co-factors or parts of enzymes that play a role in connective tissue formation and maintenance. Various soothing herbs, rich in polysaccharides and other constituents, assist the body’s natural mechanisms for soothing relief. Finally, N-acetyl cysteine, grape seed, beta carotene, vitamin C, zinc, selenium, horse chestnut, turmeric, and quercetin support the body’s natural antioxidant response, thereby helping maintain the health and integrity of joints and tissues (specifically cell membranes). GLUCOSAMINE CHONDROITIN WITH MSM: HOT RESEARCHED INGREDIENTS For added support, Source Naturals offers you a formula that combines higher potencies of the most popular joint nutrients: glucosamine sulfate, chondroitin sulfate and MSM. GLUCOSAMINE CHONDROITIN COMPLEX WITH MSM provides the same amounts of chondroitin and glucosamine shown in recent research to support healthy joints—along with MSM, vitamin C, and molybdenum, for a more powerful product. Together, these ingredients promote joint, tendon and ligament flexibility and easy joint movement. FIBRO-RESPONSE: BIO-ALIGNED FORMULA Dealing with the muscle discomfort that affects millions in our society requires more than alleviating fatigue. FIBRO-RESPONSE influences specific body systems and tissues involved in joint health and muscular metabolism. Malic acid and magnesium, supplied in the same amounts used in recent research, help support muscular energy production, along with coenzyme Q10, lipoic acid and B-complex vitamins. MSM, copper, manganese, molybdenum, zinc, vitamin C, and beta carotene support healthy connective tissue, which is essential for proper joint and muscle function. Key ingredients, including N-acetyl cysteine and silymarin aid the liver in eliminating toxic waste from blood and tissues. Ingredients including lipoic acid, selenium, N-acetyl cysteine, and coenzyme Q10 support antioxidant defense, thereby helping to maintain tissue integrity. And ginkgo and GABA are among the ingredients that support clear focus and stress reduction. LIFESTYLE TIPS FOR HEALTHY JOINTS: A STRATEGY FOR WELLNESSSM Healthy lifestyle habits should be part of your individual strategy for joint wellness. Watch Your Weight: Population-based studies, including the well-known Framingham study, have consistently shown a link between obesity and challenges to joint health. Excess weight causes pressure on joints, and can speed the rate at which cartilage wears down. Eat Healthy: To support healthy joints, increase your intake of omega-3 fatty acids from salmon, sardines, flax seeds or flax oil, avoid excess protein intake, and replace animal with plant proteins when possible. You should also eat lots of organically grown fruits and vegetables, and eliminate polyunsaturated and hydrogenated oils. Exercise Regularly: Regular physical activity helps lubricate cartilage, strengthens muscles around joints, and promotes weight control. An exercise program geared to joint health includes stretching, mild weight training, and low-impact aerobics. Rest and Relaxation: Regularly scheduled rest gives your body time to recover and rebuild, allowing you to make the most of your exercise program. It’s important to know when to slow down. Supplementation: In addition to the formulas described above, Source Naturals offers a range of products that can supplement your strategy for joint wellness. These include the pineapple enzyme BROMELAIN; SAMe, a natural compound formed from the amino acid methionine, which has been found to support joint comfort and mobility; and CM COMPLEX™ Cetyl Myristoleate, a fatty acid ester shown in recent research to reduce joint discomfort.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=160) Heart Science - A Five-Tiered Approach to Heart Health ...
Date:
June 02, 2005 12:07 PM
Your heart is crucial to every function of your body. It is the sole organ which pumps oxygen-rich blood through the entire circulatory system, feeding your cells and making life possible. Only recently are Americans realizing the importance of a proper low-fat diet, regular exercise, giving up cigarette smoking, and cutting down alcohol consumption to maintaining a healthy heart. Unfortunately, there has been a huge gap in the number of nutritional supplements which provide nutrients and herbs to support normal heart function. That’s where Source Naturals HEART SCIENCE comes in. Two years in the making, and backed by numerous scientific studies, the nutrients in HEART SCIENCE are some of the most soundly researched of all. Combining high potencies of these super-nutrients, HEART SCIENCE is the most comprehensive, cutting edge nutritional approach to proper heart care available. Source Naturals HEART SCIENCE— The Five Tiered Approach to Heart Health
Your heart never rests. Even while you sleep, your heart must keep working, relying on the constant generation of energy by the body for its very survival. If this vital organ stops beating for even a short amount of time, all bodily functions cease and life ends. Source Naturals HEART SCIENCE helps support heart function on the chemical, cellular, structural, and energetic levels. This broad spectrum formula includes ingredients specifically geared for Energy Generators for An Energetic Organ Every day, the human heart beats about 104,000 times, pumping over 8,000 liters of blood through the body! Because it requires so much energy to perform efficiently, the experts at Source Naturals included specialty nutrients in HEART SCIENCE such as Coenzyme Q10 and L-Carnitine — integral factors in the body’s energy production cycles — to enhance the body’s energy supply. There are three main interconnected energy generating cycles in our cells — the Glycolytic (sugar-burning) cycle, the Krebs’ (citric acid) cycle, and the Electron Transport Chain. Together they supply about 90 to 95% of our body’s entire energy supply, using fats, sugars, and amino acids as fuel. Coenzyme Q10 is one of the non-vitamin nutrients needed to maximally convert food into ATP (the energy producing molecule). It is the vital connecting link for three of the four main enzyme complexes in the Electron Transport Chain, the next step in energy generation after the Krebs’ cycle. Using the raw materials generated by the Krebs’ cycle, the Electron Transport Chain produces most of the body’s total energy! The heart is one of the bodily organs which contains the highest levels of CoQ10, precisely because it needs so much energy to function efficiently. CoQ10 is one of the most promising nutrients for the heart under investigation today. It has been postulated that as a result of its participation in energy production, CoQ10 improves heart muscle metabolism and the electrical functioning of the heart by enhancing its pumping capacity.8 Many factors such as a high fat diet, lack of exercise, and cigarette smoking can lead to suboptimal functioning of the heart, and therefore failure of the heart to maintain adequate circulation of blood. Interestingly, people whose lifestyles reflect the above factors also tend to have depleted levels of CoQ10 in the heart muscle.10 Researchers suggest taking between 10-100 mg per day of CoQ10;18,29 HEART SCIENCE provides an impressive 60 mg of CoQ10 per 6 tablets. Similar to CoQ10, L-Carnitine is important for energy production in heart cells. It is a natural amino acid-like substance which plays a key role in transporting fatty acids, the heart’s main source of energy, to the mitochondria, the “power plants” of each cell, where they are utilized for the production of ATP. Heart and skeletal muscles are particularly vulnerable to L-Carnitine deficiency. Studies have shown that supplementation with LCarnitine improves exercise tolerance in individuals with suboptimal heart and circulatory function, and seems to lower blood lipid status and increase HDL (good) cholesterol.16, 22 Each daily dose of HEART SCIENCE contains 500 mg of this extremely important compound. Like CoQ10 and L-Carnitine, B Vitamins help improve the ability of the heart muscle to function optimally. Each B Vitamin, after being converted to its active coenzyme form, acts as a catalytic “spark plug” for the body’s production of energy. Vitamin B-1, for example, is converted to Cocarboxylase, which serves as a critical link between the Glycolytic and Krebs’ Cycles, and also participates in the conversion of amino acids into energy. A deficiency of B coenzymes within contracting muscle cells can lead to a weakened pumping of the heart.21 HEART SCIENCE is formulated with high quantities of the most absorbable forms of B Vitamins providing maximum nutrition for the high energy demands of heart cells. Homocysteine Regulators B Vitamins also play a crucial role in the conversion of homocysteine, a group of potentially harmful amino acids produced by the body, to methionine, another more beneficial amino acid. While it is normal for the body to produce some homocysteine, even a small elevation in homocysteine levels can have negative implications. It is well documented that individuals who are genetically predisposed to having elevated homocysteine levels (homocysteinemics) tend to have excessive plaque accumulation in the arteries and premature damage to endothelial cells (cells lining the blood vessels and heart).26 Researchers have found that even those without this genetic abnormality, whose homocysteine levels are much lower than those of homocysteinemics, still have an increased risk for premature endothelial damage and the development of plaque in the arteries.24, 26 One study conducted among normal men and women found that those with the highest levels of homocysteine were twice as likely to have clogged arteries as were those with the lowest levels.24 Furthermore, it was found that the lower the research subjects’ blood levels of folate and B-6, the higher their homocysteine levels.24 Another study found that Folic Acid administered to normal men and women who were not even deficient in folate caused a significant reduction in plasma concentrations of homocysteine!3 In order to regulate homocysteine levels, it is critical to provide the body with sufficient amounts of B-6, B-12, and Folate, whether through the diet or through supplementation. HEART SCIENCE includes high levels of these three nutrients, providing B-6 in the regular and coenzyme form for maximum utilization. The Dangers of Oxidized LDL Cholesterol While many people have heard that high cholesterol levels may negatively affect normal heart function, few people understand exactly what cholesterol is, or how it can become harmful. Cholesterol is a white, waxy substance produced in the liver by all animals, and used for a variety of necessary activities in the body. Your liver also manufactures two main kinds of carrier molecules which transport cholesterol throughout the system: Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). Cholesterol is either carried out by LDL from the liver to all tissues in the body where it is deposited, or carried back by HDLs which remove cholesterol deposits from the arteries and carry them to the liver for disposal. Because of this, LDL cholesterol is considered damaging, while HDL is considered protective. Problems occur when there is too much LDL cholesterol in the body and not enough HDL. When the body becomes overloaded with fat, an over-abundance of LDL particles are manufactured to process it, and they in turn become elevated in the body to a degree that the liver cannot handle. Rich in fatty acids and cholesterol, these particles are highly susceptible to free radical attack (oxidation). Once oxidized, LDL particles are no longer recognized by the body, which attacks them with immune cells. Immune cells which are bloated by oxidized lipids (called foam cells) are a key factor in the development of “fatty streaks” — the first sign of excess arterial fat accumulation. The bloated immune cells accumulate in artery lesions and create plaque in blood vessels, leading to obstruction and constriction of the vessels. Plus, these lodged foam cells continue to secrete free radicals into the bloodstream, making the problem worse. The development of lesions in the arteries is not an uncommon problem. Arterial (and all blood vessel) walls are composed of a chemical matrix which holds the endothelial cells in place. That endothelial layer is the first and most important line of defense in preventing large molecules, such as cholesterol and fat, from entering the vessel wall. This matrix is composed of proteins, collagen, elastin, and glycosaminoglycans (amino sugars). Arterial lesions can be caused by suboptimal collagen and elastin synthesis due to three factors: 1. Vitamin C deficiency (since Vitamin C is a key building block for collagen and elastin); 2. excessive consumption of rancid fats, or heavy usage of alcohol or cigarettes; and 3. free radical damage. Once these lesions are created, the body attempts to repair them by depositing LDL cholesterol — similar to the way one would patch a tire. If that cholesterol is not oxidized, i.e. chemically changed to a harmful, unstable molecule, then this process does not create a problem. But when arterial lesions are “patched” with foam cells, arterial walls suffer page 3 page 4 even more damage, because those foam cells release free radicals which can further damage cell membranes. Unfortunately, most people have a lot of oxidized cholesterol floating through the bloodstream. The typical American diet, with its low antioxidant intake and overconsumption of fried and overcooked foods, contributes to the overall levels of harmful oxidized cholesterol. In fact, the average American intake of antioxidants is low even by USRDA standards, making Americans particularly prone to having high levels of oxidized cholesterol. Cholesterol Fighters Fortunately, there are concrete steps you can take to prevent the oxidation of cholesterol, and its subsequent ill effects on health. In addition to cutting out high-cholesterol and fatty foods, supplementation can protect existing cholesterol and all tissue cells — from oxidation. Antioxidants, substances which scavenge and neutralize free radicals, protect the cardiovascular system by halting the oxidation of cholesterol, and helping to prevent plaque accumulation in the arteries and the continual secretion of free radicals by foam cells. Supplementing the diet with high amounts of Vitamin C, a key antioxidant, also encourages a more healthy “patching” of existing lesions by using collagen (made from Vitamin C) instead of cholesterol. HEART SCIENCE contains generous amounts of the following antioxidants for their protective benefits: The Regulating Trio Three nutrients — Magnesium, Potassium, and Taurine — work closely together in the body to help maintain the normal electrical rhythm of the heart, promote proper fluid balance, and prevent excessive Calcium levels from building up in the heart and artery linings. Artery Lining Protectors Your arteries form an integral part of your cardiovascular system, carrying blood away from the heart to nourish other parts of the body. In a healthy heart, blood surges through the arteries with every beat of the heart. The arteries expand with each pulse to accommodate the flow of blood. When arteries become hardened and narrowed by the build-up of plaque, they can’t expand and are not able to transport blood efficiently throughout the body. This inability to open up increases blood pressure, putting a strain on the heart as well as the arteries. HEART SCIENCE includes ingredients specifically geared to protect against plaque formation within arteries and maintain the flexibility of these vital blood vessels. N-Acetyl Glucosamine (NAG) is a key amino sugar which forms the building blocks of mucopolysaccharides. Mucopolysaccharides, which are long chain sugars, are an integral component of connective tissue. They combine to form gel-like matrixes which are present throughout tissues in the body, helping to maintain the elasticity of blood vessels which must continually adapt to the changing pressures of blood flow. Each daily dose of HEART SCIENCE provides 500 mg — a substantial amount — of this vital tissue building block. There is evidence indicating that Silicon, a natural mineral, may protect against plaque formation in the arteries. Silicon is found mainly in connective tissues, where it helps bind the body’s chemical matrix. Bound Silicon is found in high amounts in arterial walls. Researchers have found that there is a steady decline in the Silicon content of the aorta and other arteries as we age. This may be due to the low fiber content of the typical American diet, since fiber is a key dietary source of Silicon.23 HEART SCIENCE includes 400 mg of Horsetail herb extract, a natural source of Silicon. Hawthorn Berry is without question the herb most widely used to encourage normal heart function. The beneficial actions of Hawthorn Berry on cardiac function have been repeatedly demonstrated in experimental studies. Supplementation with Hawthorn Berry has been shown to improve both the blood supply to the heart by dilating coronary vessels, and the metabolic processes in the heart, resulting in normal, strong contractions of the heart muscle.34 Also, Hawthorn may inhibit the angiotensen converting enzyme, which is responsible for converting angiotensen I to angiotensen II, a powerful constrictor of blood vessels.34 Bromelain, a natural enzyme derived from pineapples, has become well-known for its neuromuscular relaxing properties. Researchers have reported favorable results when using Bromelain for soothing vascular linings. Initial research also indicates that Bromelain may break down fibrin, the glue which holds platelets together to form blood clots.6 Capillary Strengtheners Capillaries are the smallest, yet some of the most important, blood vessels. If you think of your cardiovascular system as a series of roads which transport blood and oxygen, then your arteries are akin to interstate highways, your arterioles are the main city boulevards, and your capillaries are local residential streets. Capillaries are so small, in fact, that single red blood cells actually have to fold up to fit through them. Because of their tiny size and the intricate nature of their network throughout the body, capillaries are responsible for actually nourishing each individual tissue cell! Along the length of the capillaries are small openings called slit pores through which oxygen, glucose, and nutrients leave the capillaries and enter the surrounding interstitial fluid. From there, they cross cell membranes and nourish the cells. Similarly, the waste products of cells enter the fluid and cross over into the capillaries, where they are then transported to the liver and kidneys for disposal. If the capillary slit pores are torn or have lesions, then blood proteins and Sodium will leak out and cause the interstitial fluid to take on a more gel-like nature. This makes the transfer of oxygen and nutrients to the cells more difficult, as well as the disposal of cell waste products, turning the fluid into a stagnant swamp instead of a flowing river. In addition to its powerful antioxidant actions, Proanthodyn also helps protect collagen and elastin, the main constituents of tissue in the capillaries, and throughout the body. It is absolutely essential for capillary walls — which are only one cell thick — to be strong and stable, so that they do not allow blood proteins to leak into the interstitial fluid. Once the interstitial fluid takes on a gel-like consistency, the surrounding cells literally become starved from lack of nutrition. The exciting news is that the proanthocyanidins contained in Proanthodyn are among the few substances yet discovered which can help strengthen capillary walls, ensuring the liquid nature of the interstitial fluid.2 Plus, proanthocyanidins help keep capillary and artery walls flexible, allowing for proper blood flow to the heart. Heart Smarts The 1990’s mark a decade of increased awareness among Americans of important health issues. Much of the discussion has revolved around protecting that precious center of life we call the heart. Simple lifestyle change is one of the most effective ways to maintain and protect the functioning of the cardiovascular system. In order to take a holistic approach to heart care, make sure you include plenty of fresh fruits and vegetables (organic, if possible) in your diet, and cut down on fatty and cholesterol-forming foods. Reduce your salt and alcohol intake to a minimum. Try to get regular, sustained aerobic exercise for at least 30 minutes three times a week. Don’t smoke – or if you do smoke, try to eat even more fresh fruits and antioxidant-rich vegetables to counter the amount of free radicals being produced in your body. Lastly, consider adding Source Naturals HEART SCIENCE to your health regimen. HEART SCIENCE, the most comprehensive formula of its kind, provides targeted protection to the entire cardiovascular system. By approaching the promotion of normal heart function on five different levels — through the inclusion of ingredients which supply energy, decrease harmful homocysteine levels, fight cholesterol build-up, help regulate electrical rhythm, and protect artery and capillary linings — HEART SCIENCE is the perfect addition to a holistic approach to heart care. Source Naturals HEART SCIENCE™
Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=155) GlucosaMend™ Tissue/Joint Repair Complex
Date:
June 02, 2005 11:19 AM
More than 40 million Americans experience joint discomfort. But exciting new research proves you can do something about it. Our health and well-being is inextricably linked to lifestyle choices: the right combination of exercise, weight training and supplementation can strengthen muscles and joint tissues to minimize stress and degradation. Targeted nutrition to the multiple body systems related to joint and connective tissue can help maintain flexibility and joint comfort. GLUCOSAMEND supports the musculoskeletal system with structural building blocks and tissue production cofactors, as well as aiding the body’s mechanisms for soothing relief and antioxidant defense. Bio-Aligned Formula™ GLUCOSAMEND is uniquely effective because it is a Bio-Aligned Formula. Source Naturals evaluates the underlying causes of system imbalances. Then we design formulas that provide targeted nutrition to bring your interrelated body systems back into balance. Musculoskeletal System—Structural Building Blocks Certain building blocks of joints and connective tissue can help maintain joint integrity and comfort. Glucosamine is a major constituent of glycosaminoglycans, which in turn form proteoglycans, molecules that hold and bind the water that lubricates joints, disperses stress and nourishes joint tissue. The amino acids proline and lysine are structural components of collagen and elastin, which give strength to connective tissue. GLUCOSAMEND contains glucosamine sulfate, N-acetyl glucosamine, proline and lysine. Musculoskeletal System—Tissue Production Cofactors Some micronutrients are necessary as cofactors in the production of connective tissue. For example, vitamin C and copper help form hydroxyproline and hydroxylysine, main constituents of collagen. A unique property of grape seed extract is its ability to form a bond between broken collagen fibers, helping to repair them and restore flexibility and strength to connective tissues and joints. GLUCOSAMEND provides vitamin C, zinc, manganese, copper, and grape seed extract to address these cofactors. Soothing Relief Mechanisms Some herbs and nutrients have the capacity to support the body’s natural mechanisms for increasing comfort. Boswellia, for example, is an herb with soothing properties, while vitamin B-6 helps to stabilize collagen and elastin. Additional herbs and nutrients, acting in conjunction with antioxidant protectors, support tissue comfort and health. GLUCOSAMEND contains Boswellia serrata, quercetin, copper, and vitamin B-6. Antioxidant Defense The health and integrity of joints and tissues—specifically of cell membranes— is supported by botanicals and nutrients that support the body’s natural antioxidant response. When tissues become damaged, the body mounts a repair process that ultimately generates free radicals. These free radicals can also break down healthy cells and tissues in the process, hence the need for antioxidants to neutralize and break the cycle. GLUCOSAMEND provides grape seed extract, vitamin C, zinc, selenium, copper, quercetin to neutralize free radicals. Lifestyle Tips for Healthy Joints: A Strategy for WellnessSM Healthy lifestyle habits should be part of your individual strategy for joint wellness. Source Naturals believes in a holistic approach to living. Not only can supplements bring balances to your individual body systems but certain lifestyle choices can also bio-align your health. Exercise Regularly: Regular physical activity helps lubricate cartilage, strengthens muscles around joints, and promotes weight control. An exercise program geared to joint health includes stretching, mild weight training, and low-impact aerobics. Watch Your Weight: Population-based studies, including the well-known Framingham study, have consistently shown a link between obesity and challenges to joint health. Excess weight causes pressure on joints, and can speed the rate at which cartilage wears down. Eat Healthy: To support healthy joints, increase your intake of omega-3 fatty acids from salmon, sardines, flax seeds or flax oil, avoid excess protein intake, and replace animal with plant proteins when possible. You should also eat lots of organically grown fruits and vegetables, limit saturated fat and eliminate hydrogenated oils. Rest and Relaxation: Regularly scheduled rest gives your body time to recover and rebuild, allowing you to make the most of your exercise program. It’s important to know when to slow down. Supplementation: Source Naturals offers a range of products that can supplement your strategy for joint wellness. These include the pineapple enzyme BROMELAIN; SAME, a natural compound formed from the amino acid methionine, which has been found to support joint comfort and mobility; and CHONDROITIN to promote water retention and elasticity in cartilage and inhibit enzymes that break down cartilage. Structural Building Blocks N-Acetyl Glucosamine, Glucosamine Sulfate, L-Lysine, L-Proline Tissue Production Cofactors Grape Seed, Copper, Manganese, Zinc, Vitamins A, B-6 and C, Niacinamide Soothing Relief Mechanisms Boswellia Serrata, Quercetin, Turmeric, Copper, Magnesium, Zinc, Vitamin C Antioxidant Defense Grape Seed, Quercetin, Manganese, Selenium, Zinc, Vitamins A, C and E
References
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=152) Elan Vital - The Vital Essence of Life - Multi-Vitamin and Mineral Supplement 
Date:
June 01, 2005 01:13 PM
What makes ÉLAN VITÀL unique is its unprecedented range of nutriments in high potencies and superior forms. Quite simply, it stands alone among multiples: a quantum leap beyond maintenance...into excellence. Not only does it offer unparalleled antioxidant nutrition and a full-spectrum of essential vitamins and minerals, ÉLAN VITÀL is also formulated with specific nutrients that support: Today’s inflated levels of stress and pollution give rise to harmful free radicals – unpaired electrons that can damage living cells and compromise the proper function of tissues and organs. Antioxidants serve to protect the body by neutralizing free radicals; in fact, many scientists believe that high levels of antioxidants may prolong the effective working life span of the body’s cells. The primary strategy of ÉLAN VITÀL is to provide a wide range of antioxidants at exceptional levels, from both botanical and biochemical sources. Plantioxidant Protection ÉLAN VITÀL has the powerful advantage of Plantioxidants™, standardized botanical extracts with unparalleled free radical-scavenging properties. Plantioxidants have the unique quality of providing targeted protection because they tend to be attracted to different organs in the body. Grape Seed extract is rich in potent proanthocyanidins, a special class of highly bioavailable, water-soluble bioflavonoids that have the unique ability to cross the blood-brain barrier where they support the health of brain cells. Proanthocyanidins have been shown to efficiently scavenge oxygen radicals, as well as optimize the transport of vitamin C. They also have an affinity for collagen and elastin, the structural proteins that are abundant in vessel linings and other connective tissue. ÉLAN VITÀL contains the most concentrated extract of Bilberry available, with at least 25% anthocyanosides – compounds which are similar to proanthocyanidins but with an unusually strong attraction to optical tissue. They have been shown to protect cellular integrity in the delicate structures of the eyes. Ginkgo biloba extract is a standardized concentration of prime quality ginkgo leaves, yielding 24% ginkgoflavoneglycosides. These active compounds are potent antioxidants that have been associated with superior oxygen transport throughout the body with a special affinity for brain capillaries. Silymarin is the name given to a complex of three bioflavonoid-like compounds — silybum, silycristin, and silymarin — extracted and concentrated from milk thistle seeds. Silymarin functions in the body as an antioxidant with a special attraction for the liver. It has been researched and used extensively in Europe, where it is prized for its unique ability to nourish the liver and support its natural regeneration process by speeding up DNA synthesis in liver cells. Quercetin is a bioflavonoid present in some foods, such as onions and blue-green algae. A cousin of rutin, quercetin has been shown to stabilize cell membranes and help prevent free radical damage to this vital but vulnerable part of cells. Bioflavonoids and related compounds do their best antioxidant work when in the presence of Vitamin C, the nutrient they are most often paired with in nature. The vitamin C provided in ÉLAN VITÀL is both water- and fat-soluble. This combination is crucial because the tissues and membranes richest in fatty acids are most at risk to free radical attack. Fat-soluble vitamin C in the form of ascorbyl palmitate has an affinity for these highly vulnerable structures. Antioxidant Nutrients ÉLAN VITÀL not only provides botanical defense plants to combat free radicals, but also contains tried-and-true antioxidant nutrients: Biochemicals known as vitamins, minerals, and amino acids work together for maximum protection to all the body’s cells. The amino acid, N-Acetyl Cysteine, is a powerful and highly versatile antioxidant that doubles as a precursor to glutathione and glutathione peroxidase, two of the most formidable cell-protective compounds manufactured by the body. Studies have shown that supplemental N-acetyl cysteine enhances internal levels of glutathione far better than supplements of glutathione itself. Methionine also contributes to the synthesis of glutathione, and is an efficient transporter of certain antioxidant minerals, magnifying their activity. Vitamin A is included in both its fat-soluble palmitate form and in its provitamin form, Beta Carotene. While preformed A has long been known to play a role in the body’s defenses, beta carotene itself has recently been shown to possess a powerful ability to scavenge free radicals and contribute to the youthful function of some tissues. Vitamin E is one of the most important antioxidant compounds in nature. It works to prevent harmful oxidation within each cell and is vital in the protection of red blood cells from free radical-induced rupture. Selenium is an extremely powerful antioxidant shown in studies to work synergistically with Vitamins A, C, and E. In combination with cysteine, selenium helps build the glutathione peroxidase molecule. ÉLAN VITÀL offers a 50/50 blend of the two most scientifically supported forms of selenium: L-selenomethionine and sodium selenite. In addition to being an antioxidant itself, Zinc works closely with fat-soluble vitamin A by facilitating its release from the liver to the rest of the body. In ÉLAN VITÀL, Zinc is synergistically bound to methionine for optimal bioavailability. Copper sebacate is a natural compound that can function as the copper-SOD antioxidant system in the body, one of the first lines of defense against free radical attack. Copper sebacate is a highly absorbable form that possesses significant free radical scavenging activity. Supporting Structural Integrity An important adjunct to antioxidant nutrition is the amino sugar N-Acetyl Glucosamine, or N-A-G™. Amino sugars are essential components of cell membranes and their surface structures, as well as of the “ground substance” that holds body tissues together. They are also a key constituent of the synovial fluid in the joints. Recent research has revealed that amino sugars play an important role in maintaining the integrity of the connective and structural tissues of the body, a property that complements perfectly the actions of antioxidants: where antioxidants may prevent damage from occurring, amino sugars may help the body repair and regenerate damaged tissue. N-A-G’s activity is supported in ÉLAN VITÀL by other nutrients helpful to structural tissue. The mineral Manganese is required for building amino sugars into mucopolysaccharides, the large molecules that make up the ground substance that holds cells together. Choline and Inositol are both components of phospholipids, principal constituents in cell membranes. Two B vitamins, Folic Acid and Vitamin B12, are important to cell regeneration and to the development of healthy red blood cells. Enhanced Energy to Maximize Metabolism ÉLAN VITÀL is a potent source of coenzymes, metalloenzymes, and metabolites involved in energy production in the body. There are two main energy production cycles in the cells: the glycolytic cycle and the Krebs’ cycle. Together, they generate about 90-95% of the body’s entire energy supply – using fats, sugars, and amino acids as fuel, with enzymes as facilitators. The enzymes which catalyze energy production function in combination with coenzymes made from vitamins such as B1, B2, B3, B5 and Biotin, plus metalloenzymes made from minerals, including Magnesium, Manganese, and Copper. Biotin, an often overlooked nutrient, may function to help the body maintain a youthful metabolism. The mineral Magnesium aids in energy production, not only by acting as a cofactor to some enzymes, but also as a stabilizer of ATP, the body’s primary energy molecule. Some of the key connecting enzymes in the energy production process require two additional non-vitamin coenzyme nutrients to maximally convert food into energy: Lipoic Acid and Coenzyme Q10. Lipoic acid helps convert the end-product of the glycolytic cycle, pyruvate, into acetyl-CoA, a principal fuel for the higher energy Krebs’ cycle. Coenzyme Q10. is the connecting link for three of the four main enzyme complexes in the Electron Transport System, an off-shoot of the Krebs’ cycle, where ATP molecules are “cashed in” for energy. The muscle-supporting electrolyte mineral Potassium is in the form of Alpha- Ketoglutarate, a critical Krebs’ cycle metabolite that has additional benefits. It has long been used to improve the efficiency of ammonia-clearance from the body, an indispensable function, as ammonia is both exceedingly harmful and constantly produced through the natural metabolism of proteins. Because alpha-ketoglutarate is an organic compound well-recognized by the cells, it is an excellent transporter of potassium into the cells. Succinic Acid, or succinate, is also a metabolite in the Krebs’ cycle. It not only boosts production of ATP energy potential, but also increases the muscle cells’ production of creatine phosphate, another high energy biochemical. Chromium is the essential mineral component of glucose tolerance factor, or GTF, which functions to help insulin (one of the two main blood sugar-controlling hormones in the body) draw sugar molecules from the bloodstream into the cells. Smart Nutrients ÉLAN VITÀL contains natural substances that sharpen performance beyond just the physical. N-Acetyl L-Tyrosine is a highly stable and absorbable form of the conditionally essential amino acid L-tyrosine, a precursor to the major excitatory neurotransmitters dopamine, norepinephrine, and epinephrine. DMAE is a precursor to one of the body’s main neurotransmitters, acetylcholine. From the Plantioxidants comes standardized Ginkgo biloba extract, whose compounds readily cross the blood-brain barrier where they support the integrity of the capillaries in the brain. Guarding the Liver ÉLAN VITÀL provides several nutrients which collectively support optimal liver function. This is an essential aspect of a multiple, because the liver is responsible for converting nutrients – from food as well as from supplements – into their usable forms. If liver function is compromised in any way, nutrient supplements may be rendered inert in the body. The liver is especially at risk because it must filter out ingested toxins and is continually exposed to chemicals that generate free radicals. N-Acetyl Cysteine and Silymarin have both demonstrated a strong affinity for the liver. Nacetyl cysteine contributes to increased levels of glutathione and glutathione peroxidase, both of which the liver uses in its natural cleansing function. Silymarin provides unparalleled support to the liver’s natural regeneration process. Because of its many vital functions, the liver uses as much as 12% of the body’s energy supply, even though it represents only 3% of body weight. The liver therefore uses a greater proportion of energy nutrients, especially Coenzyme Q10 and Lipoic Acid. Both are highly concentrated in the liver; and lipoic acid in particular has been researched and used heavily in Europe where it is prized for its special protective actions in the liver. Ascorbyl Palmitate is a fat-soluble form of Vitamin C, meaning it can provide antioxidant protection for fatty tissue. This is especially valuable to the liver, which tends to develop fatty streaks that are most vulnerable to damage. Vitamin E has been researched extensively for its antioxidant properties with regard to the liver. The Multiple for the 21st Century ÉLAN VITÀL is truly a one-of-a-kind multinutrient supplement: one that leaves no nutritional stone unturned. Based on the biochemical principles of nutrition and metabolism – in context of today’s challenges to our health – ÉLAN VITÀL approaches optimal nutrition from several directions...all leading to a lifetime of health and vitality.
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Zinc monomethionine and aspartate commonly known as ZMA and Magnesium Aspartate is a supplement mostly used by people involved in great excises such as the athletes, gymnasts, and bodybuilders. Supplements help in maximum building of body muscles though some could think about creatine, weight gainers, testosterone boosters and protein powder. ZMA is one of the great supplements.
L –Carnitine is an amino acid that is naturally produced in the body. It is found in two different amino acids; methionine and lysine. Dietary sources of this amino acid include pork, beef and small amounts of milk, chicken and fish. This amino acid is highly required by the body and the following are the health benefits of Carnitine.
Several studies have been carried out, administering SAMe both orally and parenterally with promising results. Some that use it believe it more effective than the more common antidepressants, and unlike most of these it has very few side effects and a very quick onset of action: around 2 weeks in comparison to a month for most others. 
