Search Term: " C-reacive proein "
New meta-analysis finds that proper vitamin D levels greatlyimprove the health of diabetics and heart patients
May 17, 2019 04:03 PM
Up to a billion people worldwide may not be getting enough vitamin D, and this is a real problem because vitamin D deficiency can increase the risk of cancer, obesity and other health problems. Meta-analysis published by Current Pharmaceutical Design suggests that getting enough vitamin D can decrease fasting glucose and reduce insulin resistance. Vitamin D can also help moderate your bad cholesterol, as well as reducing your levels of C-reactive protein, which is a sign of inflammation.
"Three of the most significant risk factors for heart disease are high cholesterol, chronic inflammation, and insulin resistance. Researchers wanted to learn more about whether vitamin D supplementation is a way to lower the risk of heart disease or reduce complications in patients who already have it."
Read more: https://www.naturalhealth365.com/vitamin-d-glycemic-control-2947.html
5 ways aged garlic can slash your risk of heart disease
May 07, 2019 02:49 PM
Aged garlic may be remarkably effective at protecting you from heart disease, the number one killer of Americans over the last eight decades. Aged garlic extract can help protect your arteries from low-attenuation (or “soft”) plaque, even if you work in a high-stress field. Aged garlic can also help counter and neutralize the effects of C-Reactive Protein and Interleukin, both associated with the inflammation linked to cardiac disease. Aged garlic can also help prevent harmful blood clots, and may also moderate your blood pressure.
"However, as unlikely as it sounds, an extract from an everyday kitchen staple – garlic – has the potential to drastically cut your odds of becoming a medical statistic."
Read more: https://www.naturalhealth365.com/reverse-heart-disease-2778.html
Aged garlic is incredibly good for your heart
May 03, 2019 04:18 PM
Natural compounds found in aged garlic can be very beneficial to cardiac health. For example, a 2016 Los Angeles Biomedical Research Institute study on subjects with metabolic syndrome found that aged garlic extract reduced both the accumulation of new plaque within the arteries and the total amount of plaque present as well. Additional research suggests that aged garlic extract can help reduce C-reactive protein and interleukin levels. The polysulfides in garlic also support greater production of the nitric oxide that helps keep your blood vessels supple, reducing another cardiac risk factor.
"The LA BioMed researchers concluded that garlic not only decreased the amount of plaque in the arteries. The extract also stopped new plaque from appearing in the blood vessels. (Related: Aged garlic extract balances your cholesterol levels, study finds.)"
Read more: https://www.naturalnews.com/2019-03-09-aged-garlic-is-incredibly-good-for-your-heart.html
Reverse cardiovascular disease with cherries
May 01, 2019 09:23 AM
Cherries are a surprising and tasty option for lowering your risk of heart disease, thanks to their bountiful polyphenols, flavonoids and micronutrients. Like apples and grapes, cherries have lots of quercetin, which can reduce oxidative damage to your body. The deep red carotenoids and anthocyanins in cherries can fight inflammation and act as antioxidants. Cherries may also reduce your levels of C-Reactive Protein, which is associated with cardiovascular disease risk. Cherries and cherry juice are also good for regulating your blood sugar, blood pressure and cholesterol.
"In particular, the anthocyanins and carotenoids that give this stone fruit its deep red hue offer anti-inflammatory and antioxidant properties, and they also help fight obesity and diabetes."
Read more: https://www.naturalnews.com/2019-03-26-reverse-cardiovascular-disease-with-cherries.html
Pomegranate can prevent the growth and spread of four common typesof cancer cells
April 26, 2019 02:26 PM
There is a protective enzyme within pomegranate that is known scientifically as paraoxonase-1 (PON-1), and it has the ability to block oxidative stress that promote DNA mutations. These DNA mutations are often what lead to a cancer diagnosis. More research determined that not only does pomegranate help block gene mutations, but it can also stop the replication cycle of cancer cells in which they grow at alarming rates. Not only can it help disrupt this cycle, but it can also kill some cells altogether.
"In one study, a cup of day of pomegranate juice lowered inflammatory markers – such as C-reactive protein and interleukin-6 – in diabetic patients."
Read more: https://www.naturalhealth365.com/pomegranate-cancer-cells-2628.html
Why magnesium may be the single most important nutrient you need totake for heart health
April 26, 2019 10:20 AM
Magnesium deficiency, which afflicts close to 50 percent of the U.S. population, can have a profoundly negative impact on your health. Failure to consume enough magnesium can increase insulin resistance and create a higher risk of cardiac disease. A Medical University of South Carolina (MUSC) study found that magnesium-deficient people had substantially higher levels of harmful C-Reactive Proteins — associated with inflammation and heightened risk of heart disease— present in their blood. A second MUSC study confirmed this association while also noting that magnesium supplements could help reduce the health impacts of not getting enough magnesium from dietary sources.
"If you do not have enough magnesium in your body, you can become more prone to various diseases and disorders."
Read more: https://www.naturalnews.com/2019-03-11-magnesium-may-be-the-single-most-important-nutrient-for-heart-health.html
New study links negative mood with higher levels of inflammation
January 05, 2019 02:26 PM
New research from Penn State University has shown that being in a negative mood can be linked with higher levels of inflammation and may be a signal of poor health. Inflammation is a contributing factor to many diseases such as diabetes and cancer. These negative emotions include sadness, anger, and depression. 220 participants reported on their moods and blood samples were taken to measure the inflammation present in the body. This was the first study to research how the two are linked. The long-term goal of the researchers is that the information will eventually lead to insights into how interventions can improve mood and ability to cope with stress. That will in turn help break the cycle of disease associated with inflammation.
"New US research has found that a negative mood, such as feeling sad or angry, may be linked with higher levels of inflammation and may be a sign of poor health."
Read more: https://www.malaymail.com/s/1705392/new-study-links-negative-mood-with-higher-levels-of-inflammation
Is Inflammation Bad For You Or Good For You?
July 27, 2017 12:14 PM
Systemic inflammation can be a mixed bag. On the one hand, inflammation can help you during a period of injury. On the other inflammation can indicate that you are high risk for a variety of illnesses including heart disease. A test for C-reactive protein can be valuable in determining inflammation in your system, but one must be cautious as it cannot tell you what is causing said inflammation. To deal with excessive systemic inflammation, a healthy program of diet and exercise can be very helpful
"Chronic, low-level inflammation seems to play a role in a host of diseases, including type 2 diabetes, heart disease, Alzheimer's, cancer and even depression. And even though the science on inflammation and disease is far from settled, tests and treatments are being promoted that claim to reduce that risk."
Read more: http://www.npr.org/sections/health-shots/2017/07/21/538377221/is-inflammation-bad-for-you-or-good-for-you
Is C-Reactive Protein Secretly Making You Gain Weight?
June 08, 2017 09:14 AM
C-reactive protein or CRP is something that your liver increases production in when your body has increased inflammation as a result of high levels of stress, a lack of sleep or other symptoms. Inflammation is a direct cause of weight gain and in some cases, obesity. When inflamed, your body does things to deal with it, including storing more calories and slowing down your metabolism. Scientists found a common link between c-reactive protein and obesity, mostly in women.
"Here, we've asked experts to break down what's to blame for c-reactive protein in your blood, what it says about your weight, and what you can do to fight back."
Read more: http://www.womenshealthmag.com/weight-loss/c-reactive-protein
What if Depression isn't Depression? The Connection to Chronic Inflammation.
March 19, 2017 04:44 AM
Depression is a serious condition affecting millions of people around the world. More women experience depression than men, although it can affect each sex. But sometimes, the signs of depression mimic those seen in patients suffering from chronic inflammation conditions. Could it be such a condition rather than depression? Perhaps it is time to look at conditions other than depression, particularly if you are also suffering from other signs and symptoms. Learn more without delay.
"The traditional, pharmacology-centric, view of depression is that it is a chemical imbalance, usually involving serotonin."
Read more: https://goodmenproject.com/featured-content/depression-isnt-depression-connection-chronic-inflammation-lbkr/
C-reactive protein test
December 13, 2016 12:59 PM
Want to know why you have join pain? Maybe you are sore? Well when C-reactive protein levels are high in the body there is increased inflammation in the body, which can cause many problems. Your doctor can test the levels in your blood through a simple blood test, it's worth it.
"A high-sensitivity C-reactive protein (hs-CRP) test, which is more sensitive than a standard test, also can be used to evaluate your risk of developing coronary artery disease, a condition in which the arteries of your heart are narrowed. Coronary artery disease can eventually lead to a heart attack."
Can a blood test determine whether you'll be alive in 5 years?
December 11, 2016 08:59 AM
If you could find out your approximate age of death, would you want to do so? Soon to be available in the U.K , the test measures the length of telomeres, a DNA structure which controls the longevity of dividing cells. The shorter the telomere, the faster you are aging. A very specific blood test can determine telomere length and, based on the length can use an algorithm to assess longevity based on current lifestyle.
"There is growing evidence that a simple blood test could determine your risk of dying in five years."
The awesome potential of omega-3s from seafood in reducing inflammation in the human body
November 09, 2016 01:09 PM
More and more medical research is showing the profound impact that nutrition plays in our health and in disease prevention. The standard modern diet unfortunately contributes to many illnesses and diseases. Inflammation is a key factor in most health issues. Cold water seafood that is rich in omega-3 fatty acids can play a major role in reducing inflammation and maintaining good health.
"Chronic Inflammation is a symptom of virtually every disease. Inflammation plays a major role in the development of the well known chronic problems of heart disease, cancer, diabetes, arthritis, eye disease, mood disorders, fibromyalgia and the list goes on and on."
How Does Omega-7 Help Promote Healthy HDL and LDL Cholesterol Levels?
Omega 7 fatty acids are an important natural enzyme that help in the development of vital organs. They are also essential for bodily functions and are vital in improving the cardiovascular system. Another little known fact about Omega 7s is that this fatty acid is very useful in controlling cholesterol levels.
So how do Omega 7s help with cholesterol?
As you can see, Omega 7 helps the body in a variety of ways and is highly beneficial in fighting high cholesterol, blood sugar, stroke, heart disease, cancer and diabetes. So what component of Omega 7 is actually responsible for these far reaching healing properties? It is the simple acid known as palmitoleic acid.
What is Palmitoleic Acid?
Palmitoleic acid is a monosaturated Omega 7 fatty acid. It acts as a signaling enzyme that helps in communication between fat and muscle tissues. This function is quite unique and it ensures that the body maintains optimum energy levels. It also plays an important part in effective storage of fat and muscles. Hence palmitoleic acid has far reaching consequences that are highly beneficial to the human body.
Regular consumption of Omega 7 acids reap a number of benefits. They help the body in many ways. It is also one of the best options to fight high cholesterol and inflammation.
Benefits of Extended Release Guggulipid
January 03, 2013 04:10 PM
Guggul is one of the holistic ancient herbal extracts derived from the Commiphora wightii plant that had been predominant in India although some parts of northern Africa and Asia still had some traces of the same. Over the years, Guggul resin gum derived from the plant has been used to promote a healthy living, and has a good number of recent scientific research findings to back it up. Some of the health benefits associated with the use of Guggulipids supplements (also known as the Guggulsterone Supplements) include lowering of Low Density Lipoproteins (Bad Cholesterol), reducing inflammation, and significantly lowering the risk of suffering from cardiovascular diseases, tumors and cancers.
Extensive scientific research shows that Guggulipids play an important role in inhibition of its synthesis in the liver and its hydrolysis into bile salts. It also acts on the thyroid gland which in turn controls the Basal Metabolic Rate that directly relates to the rate of cholesterol catabolism in the body. Additionally, a cascade of reactions in the liver during the process of cholesterol hydrolysis down-regulates the uptake of cholesterol in the gut which ensures that the body is at a healthy blood cholesterol level.
The anti-inflammatory, anti-tumor and anti-cancer effects are highly associated with the stimulation of the liver to release C-Reactive Protein. Even though the CRP protein is primarily produced by the body in response to inflammation and cell death, presence of the CRP in the blood stream prior to an acute inflammation or cell death plays an important role in toning down inflammatory conditions such as rheumatoid inflammation as well as killing abnormal cells before they develop into tumors and cancerous cells.
However, Guggulsterones are rapidly regenerated in the body in the same rate that other steroid hormones are degenerated which makes the use of extended release Guggulipid supplements very essential. This makes it possible to have the body under constant supply of the component for optimal guggulsterone health benefits.
Can our health benefit from supplmenting choline?
November 18, 2012 11:01 AM
Choline, discovered in 1864 by the German chemist, Adolph Strecker, is an essential nutrient, usually grouped under the vitamin B family. While the human body does synthesize small amounts of choline, dietary consumption is a must in order to maintain a healthy body. Deficiency of choline can lead to a number of serious health issues including neurological problems, insomnia, accumulation of fat in the liver, damage to the kidneys and also cardiovascular disease. There are a range of important functions that choline performs in the body.
Some of the key health benefits of choline are:
Maintenance of brain health: The neurotransmitter or the messenger molecule, acetylcholine, that transmits signals from the brain to the muscles and various organs in the body such as the liver, heart, lungs etc, is synthesized using choline. Thus, it plays a very important role in memory and muscle control. Research also suggests that choline has a calming effect on the brain and helps reduce panic and anxiety attacks.
Maintenance of cell membranes: The integrity and flexibility of cell membranes depends on the presence of satisfactory amounts of choline thus making it a prerequisite for appropriate cell metabolism.
Maintenance of Liver health: Choline is responsible for preventing the accumulation of cholesterol and fat deposits in the liver hence preventing hepatosteatosis, a condition more commonly known as fatty liver.
Anti inflammatory benefits: Studies have revealed that inflammatory markers such as Interleukin-6, C-reactive protein, Homocysteine, etc., which are associated with various illnesses such as Diabetes, Alzheimer's disease, Cardiovascular disease, Osteoporosis and also various cancers, show reduced levels if adequate amounts of choline are consumed in the diet.
Apart from those stated above there are many more health benefits of choline and hence it is very important to consume foods that are rich in this nutrient. In addition to seafood and meat, foods that have high choline content include, Dairy and poultry products like Skim milk and Egg yolk, peanut butter; Vegetables such as Cauliflower, broccoli, tomatoes, Asparagus, Green beans and Fruits like Bananas and Oranges. Soybeans, due to their high lecithin content, are also a fantastic source of choline. Seeds like flax seed, sesame seeds and grains like corn, barley and oats are also rich in choline content.
Maintenance of adequate levels of choline is imperative in order to maintain optimal health. It is therefore very important to have periodic health checkups so that any deficiencies are identified and addressed as soon as possible.
March 05, 2009 01:31 PM
Inflammation is a normal part of the body’s defense against pathogens. The increase in body temperature, flood of toxic free radicals and inflammation-signaling proteins, and release of killer macrophage cells are the main signs of an inflammatory event that is the body’s long-established means of defending against a clear and present danger. This adaptive response can now become a cause for debilitating disease. It is even thought that the aging process may be linked to the very defense mechanism that keeps us healthy when we are young. As we grow older, our ability to regulate inflammation begins to diminish. Instead of protecting us, inflammation becomes silent and systemic, allowing degenerative disease to take root. The symptoms of silent inflammation are extremely different from acute inflammation of redness, heat, swelling, and pain, and can lie undetected until it has been around for far too long.
Silent inflammation causes the body to turn on itself, as its immune system begins attacking its own organs. Over time, inflammatory cytokines such as C-reactive protein, interleukin-6, and inflammation producing eicosanoids like prostaglandin E-2 and leukotrienes B-4, start to destroy tissue all over the body. In response to this attack, the body produces even more inflammatory cytokines and free radicals, which creates a self-perpetuating cycle. Silent inflammation damages arteries, destroys nerve cells and organs, compromises the immune system, and promotes cancerous growths. Despite how well they feel today, those with silent inflammation are on a fast track toward degenerative disease. On the good side, preventative measures that are taken today to reduce inflammation can prevent degenerative diseases like cardiovascular heart disease, cancer, diabetes, and Alzheimer’s tomorrow.
When there are equal numbers of good and bad eicosanoids, a state of wellness is able to prevail within the body. However, when they become chronically unbalanced, many problems result. This balance is, interestingly, highly dependant upon the level of insulin that is found in the body. High insulin levels, whether they are induced by sugar overload, the onset of insulin resistance, or the hormonal effects of excess fat, set the stage for systematic inflammation. As insulin levels climb, oxidative stress increases dramatically, causing the production of inflammatory cytokines. Along with being too high in refined sugar, the average North American diet is filled with inflammation-promoting fats and scarce in inflammation-reducing omega-3 fats; the consequence of this chronic fatty acid imbalance in an increase in systemic inflammation.
As inflammation rises, so does the production of cortisol, which is produced in the adrenal glands and is intricately involved in the body’s response to stress. In an attempt to reduce inflammation, cortisol increases blood pressure, elevates blood-sugar levels, and suppresses the immune system. This means that systemic inflammation produces chronically elevated levels of cortisol, which then place a heavy physiological burden on all organs, causing a dramatic increase on the risk of degenerative disease.
Fortunately, changing the balance within the body to favor the production of anti-inflammatory eicosanoids can be achieved through a conscious dietary change. By simply increasing your dietary intake of fatty fish, eating raw nuts and grains rich in healthy fats, and supplementing with a high-quality cold-pressed fish oil or flaxseed oil, and concurrently decreasing your intake of red meats, eggs, high-glycemic foods, and foods high in saturated fats, chronic inflammation can be reduced greatly. Vitamin supplements can boost ones antioxidant intake and help fight inflammation as well. Quality vitamins are available at your local or internet health food store.
Beyond Bran Fiber
December 25, 2007 08:35 AM
At one point in time, when you went to the health food store you usually only had choice of wheat bran, which is a good source of the insoluble fiber that helps your digestive system stay on track, or oat bran, which contains the soluble fiber that helps lower cholesterol. Although both of these bran’s are still popular, as they have good reason to be, remaining excellent sources of dietary fiber, these days store shelves are gathering more and more fiber supplements ranging from encapsulated forms to powders and specialized to deal with a variety of health concerns.
Insoluble fiber has the ability to draw water into the intestines, preventing constipation and keeping waste matter from decaying within the body. However, it is the many types of soluble fiber that science has recently started investigating for health benefits. Part of soluble fiber’s value is closely related to its mechanical action, as it forms a thick gel within the digestive track that moves slowly to stop sugar from entering the body too quickly, therefore, helping to keep glucose levels down and carrying some fat and sugar out of the body completely. Additionally, when soluble fibers gel up it helps to reduce blood level cholesterol by trapping bile preventing the bile from doing its action (breaking down fats in the digestive tract so the body can absorb it). Unlike insoluble fiber, soluble fiber undergoes fermentation inside the colon to produce fatty acids that do a little bit of everything, including: helping the body digest food, protecting against polyps, stimulating immunity, increasing mineral absorption, and helping to keep cholesterol and glucose levels in check.
Soluble fiber is getting large amounts of research reviews. One study concluded that people who ate the least fiber are 63% more likely to have high levels of CRP (C-reactive protein). CRP is an inflammation marker that is associated with cardiovascular risk. Another study proved that flax seed improved glucose control. Another fiber source, psyllium, has been shown to bring relief to people with Chron’s disease, an inflammatory intestinal disorder.
Flax seed and psyllium are two of the best known types of soluble fiber available, but there are other types that aren’t as well known. Others including arabinogalactan (AG) have been shown to have a special affinity for natural killer cells. Beta-glucans are another form of fiber that can help boost immunity. Lignans, which are found in flax, have been shown to cause lower breast-cancer rates. Fenugreek is a spice that is rich in galactomannan, a heart-healthy fiber. Some fiber formulations pair up different kinds of fiber with complementary herbs. An example of this is Garcinia cambogia and Gymnema sylvestre, which can be used for glucose control; or astragalus, Echinacea, olive leaf, and shiitake to assist the immune system. Some supplements even provide natural enzymes which help prevent bloating.
It is, of course, important to eat a healthy and well-balanced diet. However, thanks to supplementation that is designed specifically for certain health concerns, it has become much easier to find the additional fiber that is needed by your body, no matter what kind of fiber that is. A large selection of fiber bran supplements can be found at your local or internet health food store.
Magnesium May Help Reduce Inflammation…
August 03, 2006 03:39 PM
Magnesium May Help Reduce Inflammation… Taking a daily supplement of magnesium may help reduce the levels of a type of inflammation that could lead to heart disease in people with low dietary intake of minerals. According to research published in Nutrition Research (2006, Vol.26: 193-196), Magnesium intake from supplements has an impact on the likelihood of having elevated C-reactive protein (CRP), “Separate from and in addition to dietary intake.” CRP is a pro-inflammatory cytokine—a signaling molecule associated with increased inflammation. The researchers used data from the National Health and Nutrition Examination Survey 1999-2000 and focused on 10,024 people with valid measurements of both CRP levels and dietary and supplemental intake of magnesium. Among other findings, the study showed that people with a total (Dietary plus supplement) magnesium intake below the U.S. recommended daily allowance (420 milligrams for men over 20 and 320 milligrams for women over 30) were found to be 40 percent more probably to have elevated CRP levels.
along with the mineral Magnesium, trace minerals are the catalysts for all the vitamins and other nutrients your body uses for developing and maintaining good health. try out one of these trace mineral supplements which supplies 250mg of Magnesium as well as 72 trace minerals.
More evidence supporting high-fiber diet…
April 15, 2006 01:40 PM
More evidence supporting high-fiber diet… Eating a diet high in fiber significantly lowered levels of c-reactive protein (CRP), which is associated with inflammation, diabetes, and heart disease. Increased levels of CRP are a good predictor of the onset of both type-2_diabetes and cardiovascular disease. Published in the American journal of clinical nutrition (2006, vol.83, no.4: 760-766), the prospective observational study measured usual intake of carbohydrate, protein, fat and fiber. Over 500 subjects with an average age of 48 participated in the year-long study. Insoluble fiber intake was associated with 68 percent reduction in CRP levels, while soluble fiber was associated with a 42 percent reduction.
HDL Booster - Boost your good cholesterol
March 16, 2006 12:51 PM
(Product No. 02922)
HDL Booster is a physician-developed dietary supplement that has been clinically shown to increase good cholesterol levels, particularly HDL-2, the best form of cholesterol.* The formula combines essential vitamins and minerals, at levels recommended by the American Heart Association (AHA), with key amino acids, powerful antioxidants, and traditional herbal extracts to provide superior support for cardiovascular health.*
· Formulated by Dr. Dennis Goodman, Chief of Cardiology at
· Clinically studied to increase good cholesterol levels up to 23%*1
· All-inclusive formula; includes ingredients recommended in accordance with the American Heart Association
· Replaces the CoQ10 depleted by cholesterol lowering (statin) drugs.*2
HDL Booster has been clinically shown to increase HDL cholesterol levels.* HDL Booster also supports healthy cholesterol and healthy triglyceride levels already within the normal ranges.* By reducing C-reactive protein levels, HDL Booster helps support the body’s natural anti-inflammatory response.*
Two tablets (one serving) contain:
Vitamin C (ascorbic acid) 148 mg
Vitamin E (as natural mixed tocopherols) 35 IU
Niacin (as niacinamide) 21 mg
Vitamin B6 (as pyridoxine HCl) 3 mg
Folic Acid 301 mcg
Vitamin B12 (as cyanocobalamin) 20 mcg
Magnesium (from magnesium amino acid chelate) 10 mg
Selenium (as L-selenomethionine) 49 mcg
Proprietary Blend 388 mg
hawthorn (Crategus oxyacantha) berry extract,
taurine, garlic (Allium sativum) bulb, grape seed (Vitis
vinifera) extract, grape skin (Vitis vinifera) extract,
N-acetyl-L-cysteine, alpha-lipoic acid, soy (Glycine
max) isoflavones, tocotrienols
L-Arginine (as L-arginine HCl) 153 mg
L-Carnitine (as L-carnitine L-tartrate) 51 mg
Coenzyme Q10 (CoQ10)(ubiquinone 10) 25 mg
Policosanol 7 mg
Other ingredients: See label for most current information.
Contains no: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring, or preservatives. This product contains natural ingredients; color variations are normal.
Cholesterol, the soft, waxy substance present among the lipids (fats) in the bloodstream and in all cells, is important for wide variety of physiological functions. It is essential for the formation of cellular membranes, necessary for the production of bile salts, and also plays a role in the synthesis of certain hormones.3-5
Cholesterol is both produced by the body and obtained from food. Endogenous cholesterol is formed by human cells, particularly liver cells, whereas exogenous cholesterol is absorbed through the gastrointestinal tract from food.3,4
Because cholesterol can not be metabolized for energy, it must be removed from the body once it has served its function. The major route of removal is through the liver, where it is processed and subsequently excreted from the body.3,4
Types of Cholesterol
Cholesterol is lipophilic (“fat loving” or water insoluble) by nature. It can not be dissolved in the blood, and must, therefore, be transported by carriers known as lipoproteins. These carriers are classified by density, with LDL (low density lipoproteins) and HDL (high density lipoproteins) being the most common.4,5
LDL is often referred to as “bad” cholesterol. LDLs carry cholesterol throughout the body. Conversely, HDL, or “good” cholesterol, is responsible for carrying cholesterol away from the arteries to the liver where it is eventually processed and eliminated from the body.3,4,6
Scientific studies have shown that both types of cholesterol are important indicators of cardiovascular health. But recent research, focusing on the beneficial subtypes of HDL, has found that certain fractions of HDL may be more supportive of cardiovascular health than others. The two most notably supportive HDL fractions are HDL-2 and HDL-3.7
The smaller HDL-3 is synthesized by the liver and intestines. This form, which is known as “free cholesterol-rich” HDL, scavenges or “scoops up” free cholesterol. The cholesterol is then chemically altered by the addition of an ester group. When sufficient cholesterol is esterified, HDL-3 becomes HDL-2, which is therefore referred to as “cholesterol ester-rich” HDL. HDL-2 is larger in size and has been shown to be more cardiosupportive than HDL-3.*7
HOW IT WORKS:
HDL is known to possess antioxidant activity and to help balance the body’s natural anti-inflammatory response, both of which are important for cardiovascular health, but its most important function is the role it plays in cholesterol transport.6,8 High levels of HDL cholesterol are also associated with reduced platelet activity, another key indicator of arterial and venous health.9
Both HDL and LDL levels are important indicators of healthy cardiovascular function.* Therefore, supplements that increase the level of good cholesterol can profoundly impact heart health.* In 2002, an open label pilot study was conducted at
The following chart summarizes the benefits of each of the ingredients in HDL Booster:
Sytrinol - A Natural Solution for Addressing Cholesterol
June 21, 2005 05:16 PM
By Richard F. Staack, Ph.D., M.B.A.
Sytrinol™, a patented proprietary formula derived from natural citrus and palm fruit extracts, combines citrus polymethoxylated flavones (PMFs), palm tocotrienols and other proprietary constituents. This combination results in a synergistic effect for maintaining cholesterol levels in the normal range, including total cholesterol, LDL cholesterol, and triglyceride levels, as demonstrated by a long-term, three-phase clinical trial. This trial is extremely significant because it is a randomized, placebo-controlled, crossover design, one of only a few in the dietary supplement industry. Sytrinol has also been shown to maintain normal levels of high-density lipoproteins (HDL), the beneficial cholesterol. Additionally, Sytrinol is a powerful antioxidant with numerous heart health benefits and also plays a significant role in reducing cellular irritation.
What are polymethoxylated flavones?
Polymethoxylated flavones are a highly methoxylated sub-classification of citrus flavonoids. This process occurs naturally and results in a more biologically active molecule. This is especially true for tangeretin and nobiletin, two of the primary polymethoxylated flavones in Sytrinol. Tocotrienols, naturally occurring analogues of tocopherol (natural vitamin E), are the other proprietary ingredient in Sytrinol and are a group of minor dietary constituents that have been studied for their effect on heart health.
Sytrinol's Proven Benefits
Sytrinol is the result of over 12 years of research focusing on the relationship between polymethoxylated flavonoids, tocotrienols, and cardiovascular health. Sytrinol?s benefits have been shown in vitro, in vivo, and in multiple clinical studies. In these studies, subjects consumed 150 mg of Sytrinol twice per day (300 mg/day) and were instructed to keep the same dietary habits and maintain their caloric intake. Fasting blood samples were drawn at study onset, and at 4-weeks, 8-weeks, and 12-weeks. The results of the clinical studies were all similar in their effect, with a reduction of total cholesterol up to 30 percent, LDL cholesterol up to 27 percent, and total triglycerides up to 34 percent in twelve weeks compared to the placebo group. Additionally, the LDL/HDL ratio was significantly reduced in all clinical studies up to 30 percent. Another very important benefit of Sytrinol that cannot be claimed by other cholesterol-addressing supplements is its effect on C-reactive protein (CRP), which plays a role in cardiovascular challenges. Recent research has established that inflammation may cause C-reactive protein to be produced in the body. Specific PMFs, including nobiletin and tangeretin, have been studied for their anti-inflammatory properties, suggesting that Sytrinol may have a positive effect on CRP Sytrinol has also been shown to be a powerful antioxidant. The polymethoxylated flavones have been researched for over 25 years demonstrating their antioxidant effects for heart health. Studies have shown that polymethoxylated flavonoids and their metabolites are excellent sources of dietary antioxidants that are able to suppress many of the events of free radical damage, including cellular irritation. The tocotrienols in Sytrinol have a higher antioxidant activity than tocopherols. Alpha-tocotrienol has been shown to be up to 60 times more potent than alpha-tocopherol in the prevention of lipid peroxidation. Other research has demonstrated that the delta and gamma isomers of tocotrienols also have potent antioxidant activity.
Sytrinol has three complementary mechanisms of action in the body that delivers cardiovascular benefits. *Polymethoxylated flavones decrease apolipoprotein B, the structural protein needed for endogenous synthesis of LDL cholesterol. *Polymethoxylated flavones (tangeretin & nobiletin) decrease diacylglycerol acetyl transferase, a liver enzyme needed for endogenous synthesis of triglycerides. *Tocotrienols inhibit HMG CoA reductase, the liver enzyme responsible for endogenous synthesis of cholesterol. These mechanisms work synergistically to support normal total cholesterol, LDL cholesterol, and triglyceride levels, more significantly than other natural supplements on the market today. Sytrinol can also be combined with other ingredients such as phytosterols. Phytosterols help block cholesterol in the gastrointestinal tract while Sytrinol helps block cholesterol synthesis in the body. This suggests that, when combined, a more pronounced effect on maintaining normal cholesterol levels would result.
The ease of compliance for consumers is a major consideration for a successful natural heart health product. Consumers do not have to take Sytrinol prior to, immediately following, or directly with their meals and, as a result, are more likely to take the correct dosage and continue using the product. Sytrinol can be taken in tablets, or softgels, which are easy to swallow because of the low dosage. Sytrinol will also be available in functional foods.
Dr. Richard Staack is the Vice President of Business Development, Technology, and Science at SourceOne™ Global Partners. He received his Master of Science and Doctorate in Nutritional and Biochemical Toxicology from the University of Illinois, Urbana-Champaign. He received his Master of Business Administration with Distinction from DeVry University. Dr. Staack has received several awards and honors in the field of nutrition, is associated with numerous professional affiliations, and has published several articles on nutrition and toxicology in peer-reviewed journals.
Disclaimer: the above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider.
May 09, 2005 06:10 PM
It's in the BloodNatural alternatives abound for managing cholesterol levels, backed by a growing body of research ©VR By Paul Bubny
The National Cholesterol Education Program (NCEP) last July lowered the threshold for considering the use of statin drugs—a move which some say was motivated more by profits than scientific evidence. For example, the Center for Science in the Public Interest pointed out that eight of the nine authors behind the new recommendations had financial ties to statin manufacturers, which stand to reap billions of dollars more from a category that grossed $14 billion in the U.S. last year. And though the Food and Drug Administration (FDA) in January decided against authorizing over-the-counter (OTC) sales of statin drugs, drug companies would still like to see this happen.
“The medical establishment’s pushing of these drugs to becoming the number one category of prescribed drugs in the world has led them to keep lowering the total cholesterol number that triggers the drug recommendation,” said Neil E. Levin, C.C.N., D.A.N.L.A., nutrition educator, product formulator, and “Truth Advocate” for NOW Foods (Bloomingdale, IL), which produces a number of supplements for addressing cholesterol. “This is despite the lack of evidence that total cholesterol means much as regards cardiovascular risks.
“Other tests are much more important in terms of predicting risks, including CRP (C-reactive protein), the balance of different cholesterol fractions, and homocysteine,” he continued. “Add adult-onset diabetes to the risk factors for cardiovascular disease (CVD).”
At the same time, the allegation that enormous sales potential lay behind the lower threshold for prescribing statin drugs illustrates how widespread the problem of hypercholesterolemia (elevated total cholesterol) is. More than 100 million Americans have elevated cholesterol (total cholesterol values of 200 mg/dl and higher), and of these, more than a third have high cholesterol (levels of 240 mg/dl and higher), according to the American Heart Association. Those numbers have unfavorable implications for the incidence of CVD, as high cholesterol is considered a risk factor for coronary heart disease and stroke.
While statin drugs haven’t garnered the same degree of negative publicity that COX-2 inhibitors have suffered lately, safety concerns have arisen nonetheless. For one thing, these drugs lower the liver’s production of coenzyme Q10 (coQ10) along with its production of cholesterol. “CoQ10 is related to energy production and immune functions, is an antioxidant, and [is] an important cardiovascular nutrient,” Levin said. “It is not good to lower one’s coQ10 levels by half!”
Moreover, said Levin, statins increase the tendency of muscle tissues to break down. “Combined with inactivity or certain drugs, this can stimulate muscle wasting,” he said. “Muscle is where a good deal of calories are burned, so a loss of muscle could affect mobility and energy production, potentially adding to obesity problems. These muscle changes occurred in patients and persisted for years after treatment was discontinued, as shown by muscle biopsies, even if no obvious muscle problems were observed by the patients.”
And the last word on the subject may not have been spoken. Predicted Dr. Frank King, Jr. president of King Bio Natural Medicine (Asheville, NC), “Once the appropriate studies are finished, these drugs, along with hypertensives, will hit the fan bigger than the COX-2 inhibitors.”
Also looking toward the future, Levin said that of the 20 million Americans who will be “targeted” for statin drug prescriptions under the new NCEP guidelines, “Some of these will want to try natural methods first. Others will rebel at the side effects of the drugs and experiment with alternative products.”
King and Levin both saw opportunity for natural products in the fallout from drug safety concerns, with King projecting that sales of his company’s cholesterol-related homeopathic remedies will double in 2005. “The reports of deaths from drugs will always overshadow the trumped-up studies and news reports blasting dietary supplements,” said Levin. “Vioxx knocked vitamin E off the media’s radar screens pretty rapidly, though we still see ignorant reporters citing that [Johns Hopkins] vitamin E analysis as if it were true. But the comparable safety of supplements means that open-minded people will want to at least try natural therapies before signing in to a lifetime of drug therapies. Meanwhile, the studies on natural products will continue to build our credibility.”
Those studies keep coming in, with at least four major findings published in the past few months, plus a heart-health claim on walnuts authorized by FDA. They join a raft of earlier findings that link natural products—branded and otherwise—to healthy cholesterol levels.
"Blur of Products"
With so many natural alternatives to cholesterol drugs available, it can be hard to keep track. “As with any other category, the blur of products as they cascade over several shelves means that the retailer needs to have a good sense of what works and what they want to recommend to their customers,” Levin said. “Really, each person needs a protocol that would include antioxidants, fiber, vitamins, herbs, and oils. The pre-mixed cholesterol support formulas are a good starting place.”
To help retailers get a sense of “what works,” here is an alphabetical discussion of several nutrients that have demonstrated benefits in serum cholesterol levels. They include the following:
Barley may help lower cholesterol, according to a report in the American Journal of Clinical Nutrition (2004, vol.80, no.5: 1185-1193). Twenty-five adults with mild hypercholesterolemia consumed a controlled diet low in total fat, saturated fat, and cholesterol for 19 weeks. They then added whole-grain products containing barley to their diets that contained low (0 g), medium (3 g), or high (6 g) amount of beta-glucan per day for five weeks. Total cholesterol was reduced by 4 percent 9 percent, and 10 percent, respectively. The diet with the highest amount of beta-glucan led to a decrease in LDL cholesterol of 17 percent.
Chromium. There’s evidence, Levin said, that chromium in doses of 500 mg a day may decrease levels of low-density lipoprotein (LDL, the so-called “bad” cholesterol) and total cholesterol while raising levels of high-density lipoprotein (HDL, or “good” cholesterol). At the annual meeting of the American College of Nutrition last October, a poster presentation on the safety of Benicia, CA-based InterHealth Nutraceuticals’ ChromeMate niacin-bound chromium won first prize; among other things, the presentation cited chromium’s role in maintaining healthy blood lipid levels.
Fatty Acids. The latest in a long line of studies demonstrating the benefits of fatty acids in heart health is a study published in The International Journal of Clinical Pharmacology and Therapeutics in December 2004. It showed that docosahexaenoic acid (DHA), an omega-3 fatty acid, can restore normal blood vessel function in children with inherited high cholesterol. The study, which used Martek DHA produced from microalgae, concluded that restoration of normal blood vessel function has the “potential for preventing the progression of early coronary heart disease in high-risk children.”
“The evidence continues to accumulate on the cardiovascular benefits of DHA for people of all ages,” said Henry “Pete” Linsert, Jr., chairman and CEO of Martek Biosciences, an ingredient supplier based in Columbia, MD. “This study clearly indicates that DHA played an important role in healthy blood vessel function in the children in this study.”
On the Omega-Research.com Website maintained by fish oil manufacturer Nordic Naturals (Watsonville, CA) can be found summaries of several earlier studies linking omega-3 fatty acids to maintaining healthy blood lipid levels, as well as related benefits such as elasticity of the arteries. In a 2003 study published in the American Journal of Clinical Nutrition, it was found that women receiving a mixture of 4 g eicosapentaenoic acid (EPA) and DHA along with 2 g of gamma-linolenic acid (GLA) had lower levels of LDL cholesterol after 28 days compared to those who received either the EPA/DHA supplements without DHA, EPA/DHA with a smaller dose of GLA, or GLA alone.
Flax is another source of omega-3s, and Arkopharma/Health From The Sun (Bedford, MA) offers FiProFLAX in a variety of forms. Marketing director Hugues P. Mas said the flax is “QAI [Quality Assurance International] certified organic and guaranteed GMO [genetically modified organism]-free.” On its Website, the company offers a cholesterol quiz geared to consumers, discussing the importance of omega-3s as well as other nutrients.
Garlic. Adding to an already considerable body of research demonstrating that garlic can lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol, researchers at UCLA in 2003 reported that Kyolic aged garlic extract reduced or inhibited plaque formation in the arteries of 19 cardiac patients taking statin drugs.
Lead researcher Matthew Budoff, Ph.D. commented at the time that the study “suggests that aged garlic extract may be a useful and beneficial dietary addition for the people who have high cardiovascular risk or who have undergone heart surgery.” Budoff has since presented several trade show seminars sponsored by Los Angeles-based Wakunaga of America, the makers of Kyolic.
Guggul. In use for centuries as a component of Ayurvedic medicine, guggul—a gummy resin tapped from the Commiphora mukul tree, which is native to India—has been studied since the early 1960s for its hypolidemic (blood-lipid lowering) properties. Sabinsa Corp. (Piscataway, NJ), an ingredient supplier which produces a standardized extract under the brand name Gugulipid, says the studies on guggul indicate that its hypolipidemic activity can be attributed to more than one mechanism of action.
Among the possible mechanisms are: inhibition of cholesterol biosynthesis, enhancing the rate of excretion of cholesterol, promoting rapid degradation of cholesterol, thyroid stimulation, alteration of biogenic amines, and “high affinity binding and anion exchange.”
Homeopathy. “Homeopathy activates the body’s own control system to work properly,” said King. “This is the safest and most curative approach to take.
“Forcing the body into biochemical change even naturally doesn’t actually have the curative action of homeopathy,” King continued. “Homeopathy can even correct the genetic predispositions to disease we may have inherited from as deep as a thousand years into our family chain.” King Bio makes Artery/Cholesterol/BP, a homeopathic formula intended to help tone heart muscles and blood vessels.
Low glycemic index foods. In a study published in the February issue of the American Journal of Clinical Nutrition, researchers found that high glycemic load is negatively correlated to serum levels of HDL cholesterol. Assessing the relationship between blood levels of lipids and diet in a test population of 32 healthy males and females ages 11 to 25, the researchers found that glycemic load accounted for 21.1 percent of the variation in HDL cholesterol. They concluded that glycemic load appears to be an important independent predictor of HDL cholesterol in youth and noted that dietary restrictions without attention to glycemic load could unfavorably influence blood lipids.
Medicinal Mushrooms. Although its product SX-Fraction is intended primarily to address high blood sugar, Maitake Products, Inc. (MPI, Ridgefield Park, NJ) found in a clinical study that LDL cholesterol in diabetic patients declined modestly (from 142 mg/dl to 133 mg/dl) over a two-month period. Those taking SX-Fraction also lost about 7 lbs. in the same time period.
“The more impressive lowering of cholesterol, however, comes from the dietary fiber that is found in all medicinal mushrooms,” said Ellen Shnidman, manager of scientific affairs at MPI. She cited animal studies which documented the cholesterol-lowering properties of four different mushrooms: maitake, shiitake, agaricus, and enokitake.
For example, a study reported in the September 1996 issue of Alternative Therapies showed “a 44 percent reduction in total cholesterol in rats consuming maitake mushroom in their diet,” said Shnidman. “This cholesterol reduction is accompanied by weight loss, relative to rats eating a similar high-choelsterol diet without mushrooms. Apparently, cholesterol is excreted by the rats in sufficient quantity to aid in weight loss.”
Oat bran. A 2004 consumer study conducted by the Natural Marketing Institute (NMI, Harleysville, PA) for Nurture, Inc. (Devon, PA), which produces the ingredient OatVantage, found that 63 percent of consumers managing their cholesterol levels prefer oat-based ingredients.
Oat bran is the subject of a health claim authorized by FDA in 1999, and NMI research found that 69 percent of respondents preferred the FDA-permitted health claim, “Helps Lower Cholesterol,” over the model structure-function claim, “Helps Maintain Healthy Cholesterol Levels.” “This is significant for food, beverage, and dietary supplement manufacturers who want to increase sales by using a more consumer-desired claim on the product label,” said Griff Parker, Nurture CEO.
Plant sterols. Also the subject of an FDA-approved claim for heart health, plant sterols (structurally similar to cholesterol in humans) can block the absorption of cholesterol, according to a number of studies. In an “Ask the Doctor” publication (available online at www.atdonline.org), Decker Weiss, N.M.D. noted that sterols enter the same receptor sites that cholesterol enters on its way to the bloodstream. “The cholesterol, being blocked from absorption, remains in our intestines where it is eventually excreted,” Weiss wrote. General Mills has just introduced Yoplait Healthy Heart, a yogurt high in plant sterols.
Policosanol. A mixture of fatty alcohols derived from sugar cane or beeswax, policosanol has been favorably compared in clinical studies to several types of prescription drugs for managing cholesterol. On its own, policosanol was found in a 1999 study to reduce LDL cholesterol while raising levels of HDL cholesterol.
Probiotics. “Several studies have indicated that consumption of certain cultured dairy products resulted in reduction of serum cholesterol, as well as triglycerides,” wrote Dr. S.K. Dash, president of probiotic manufacturer UAS Laboratories (Eden Prairie, MN), in his Consumer Guide to Probiotics. Among other studies, Dash cited two controlled clinical studies from the VA Medical Center at the University of Kentucky.
“In the first study, fermented milk containing [Lactobacillus] acidophilus was accompanied by a 2.4 percent reduction of serum cholesterol concentration,” he wrote. “In the second study, a different L. acidophilus strain reduced serum cholesterol concentration by 3.2 percent. Since every 1 percent reduction in serum cholesterol concentration is associated with an estimated 2 to 3 percent reduction in risk for coronary heart disease [CHD], regular intake of fermented milk containing an appropriate strain of L. acidophilus has the potential of reducing risk for [CHD] by 6 to 10 percent.”
Dash said his company’s DDS Probiotics contain DDS-1 L. acidophilus, “which has been researched and demonstrated to show cholesterol-lowering effect.”
Psyllium. “Internal cleansing is very important” in maintaining healthy cholesterol levels, “especially if you do it with a lot of fiber,” said Sunil Kohli, vice president of Chino, CA-based Health Plus, Inc. The cholesterol-managing ability of fiber in general and psyllium in particular is “very well-established,” he said.
However, Kohli said, “It will probably do you no good if it’s random. It should be done on a regular basis, and it should be supervised. Consulting the doctor or pharmacist is important.”
Soy. The protein in soy “has evidence of lowering total cholesterol and LDL cholesterol, based on reviews of studies using over 20 g of soy protein per day,” said Levin. “Soy isoflavones are considered only partly responsible for this effect.”
Sytrinol. A patented proprietary formula derived from natural citrus and palm fruit extracts and containing citrus polymethoxylated flavones and palm tocotrienols, Sytrinol has been shown in clinical trials to improve total cholesterol, LDL cholesterol, and triglycerides by up to 30 percent, 27 percent, and 33 percent, respectively. Having just wrapped up Phase III of a long-term trial of Sytrinol, Chicago-based SourceOne Global Partners, which owns the exclusive worldwide license for intellectual property associated with the ingredient, is commencing a study that combines Sytrinol with plant sterols.
Tocotrienols. On its Website discussing the science and benefits of tocotrienols (www.tocotrienol.org), ingredient supplier Carotech Inc. (Edison, NJ) identifies several benefits for blood lipid levels. Tocotrienols, according to the Website, have been shown to “inhibit cholesterol production in the liver, thereby lowering total blood cholesterol;” “[suppress] hepatic HMG-CoA reductase activity [and result in] the lowering of LDL cholesterol levels;” and “inhibit cholesterogenesis by suppressing HMG-CoA reductase.”
With all of this, Levin said, it’s important for retailers to remember that “they are not allowed to discuss diseases and remedies unless there is an approved FDA health claim allowed on the label, as with soy protein and plant sterols. What is allowed are structure-function claims such as ‘cholesterol support,’ ‘promoting normal, healthy circulation,’ ‘homocysteine regulators,’ etc.”
Supplementation is only one tool for managing cholesterol levels, manufacturers pointed out. “Besides nutrition, lifestyle is a key to controlling cholesterol,” Levin said. “Eating a variety of antioxidant-rich foods will prevent the liver from churning out cholesterol as a ‘cheap’ antioxidant. The body uses oxidized cholesterol to patch leaky and damaged blood vessels, so the ability to build healthy collagen is a must, using nutrients like vitamin C, Pycnogenol, rutin, hyaluronic acid, and MSM.
“Don’t forget exercise and stress reduction,” he added. “Stress results in high cortisol levels—usually accompanied by poor blood lipid levels—and a lack of good sleep to produce unhealthy people.” VR
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