“How do we Justify taking on another line of products?”

Eliminating slow-moving items is a great way to make room for NOW’s line of affordable high-quality products. Your bottom line cant afford to have shelves full of products that do nothing but collect dust. Our commitment to providing products that people actually want at prices that they can afford will help you overcome this common hurdle.

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Vitanet ®

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Date: July 15, 2005 12:24 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: STEVIA (Stevia rebaudiana)

STEVIA (Stevia rebaudiana)

SYNONYMS: sweet herb, honey leaf

PARTS USED: leaves

Description

Stevia is a small perennial shrub with green leaves that belongs to the aster (Asteraceae) or chrysanthemum family of plants. They grow primarily in the Amambay mountain range of Paraguay but over 200 various species of stevia have been identified around the globe. Stevia rebaudiana is the only species at present which possesses an inordinate ability to sweeten. Its common form is known as stevioside, a fine white powder extracted from the leaves of the plant. Phytochemistry STEVIOSIDE/REBAUDIDOSIDE COMPOUND DUO: The leaves of the stevia shrub contain specific glycosides which produce a sweet taste but have no caloric value. Stevioside is the primary glycoside involved in this effect. Dulcoside and rebaudioside are also major glycosides contained in the herb. Glycosides are organic compounds which contain a sugar component (glycone) and a non-sugar component (aglycone). The glycone constituent may be comprised of rhamnose, fructose, glucose, xylose, arabinose etc. The other portion may be any kind of chemical compound such as a sterol, tannin, carotenoid, etc.

Stevia leaves also contain protein, fibers, carbohydrates, phosphorus, iron, calcium, potassium, sodium , magnesium, rutin (flavonoid), iron, zinc, vitamin C and vitamin A. Human physiology cannot metabolize the sweet glycosides contained in stevia leaves, therefore they are eliminated from the body with no caloric absorption. Stevia, unlike aspartame, can be used in baking because its sweet glycosides do not break down when heated. Definition Stevia is an herb with incredible sweetening power. Its ability to sweeten is rated between 70 to 400 times that of white sugar. Typically, it has a mild licorice-like taste and is completely natural in its biochemical profile. What makes stevia so intriguing is that unlike other natural sweetening agents, its is completely calorie-free, never initiates a rise in blood sugar, and does not provide “food” for microorganisms like bacterias and yeasts.

Stevia may well be the most remarkable sweetener in the world and yet its recognition in this country remains relatively low. Consider the extraordinary attributes of the stevia plant and its extracts:

A Brief History

Stevia is a plant indigenous to mountainous regions of Brazil and Paraguay. For centuries, this herbal sweetener has been used by native cultures to counteract the bitter taste of various plant-based medicines and beverages. The Guarani Indians of Paraguay have used this potent sweetener in their green tea for generations. The name they designated for stevia leaves was “sweet herb.” In addition, these native peoples have historically used stevia as a digestive aid and a topical dressing for wounds and other skin disorders.

In the sixteenth century, Europeans became aware of the herbal sweetener through the Spanish Conquistadors. In the late 1880s, Moises S. Bertoni, director of the College of Agriculture in Asunción, Paraguay, became extremely intrigued by the stevia plant. Its reputation was that it was so sweet that even just a small leaf part could sweeten an entire container of mate tea. Be rtoni wanted to find out if this was true. After several years of studying the plant, he wrote about it in a local botanical publication. In 1905, Bertoni published an important article about the incredible sweetening power of the stevia plant, which he considered superior to sugar and extremely marketable. Other articles written by Bertoni note that stevia is unquestionably superior to saccharine because it is nontoxic and has significant therapeutic benefits. It sweetens with unprecedented potency and can be used in its natural state.

The first stevia crop was harvested in 1908 and subsequently, stevia plantations sprang up in South America. In 1921, the American Trade Commissioner to Paraguay, George S. Brady, wrote that although the herb is an extraordinary sweetener with remarkable properties, little had been done to commercially cultivate the plant. He suggested that stevia may be an ideal sugar product for diabetics and strongly advised that American companies pursue its importation.

During the decade of the 1970s, the Japanese developed a new method which could better refine the glycosides contained in the stevia leaf. The result was a compound called ste-vioside which is from 200 to 300 times sweeter than white sugar. The Japanese approach artificial sweeteners with great caution and they believe stevioside to be safer and more effect i've than other non-nutritive, chemical products. Stevioside is considered superior in its ability to sweeten; however, it does not exhibit some of the other therapeutic actions found in whole stevia leaves .

Stevia enjoyed substantial popularity during the 1980s as a natural sweetener and was found in a variety of consumer products. In 1986, however, the FDA abruptly seized stevia inventories and in 1991 claimed it was not suitable as a food additive. Advocates for stevia claim this happened because the herb is a natural, powerful, inexpensive and non-patentable sweetener, and therefore poses a threat to pharmaceutical sweeteners and sugar-alcohol sweeteners like mannitol, sorbitol and xylitol. At this writing, stevia has received approval by the FDA to be sold only as a dietary supplement, not as a sweetening agent.

Currently, stevia is commercially grown in Paraguay, Brazil, Uruguay, Central America, Israel, China, Thailand, and the United States. It is considered an important natural sweetener in both Japan and Korea, and has been safely used in these countries for decades. Extracts of stevia and related products make up a considerable portion of the Japanese market for natural sweetening agents. They use stevia in sweet sauces, pickles, beverages, etc., making Japan one of the largest single consumers of stevia in the world. Today, because the demand for stevia is escalating, several Paraguayan organizations are looking to expand the commercial cultivation of the plant. Currently, Canadian researchers and chemists are working to provide even better stevia supplements and may even end up teeming with governmental agencies to raise stevia crops as economic replacements for tobacco leaves (Bonvie, 64). Stevia has not been officially approved by Canadian agencies, but it is still available for purchase in tea form.

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Date: July 14, 2005 09:28 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Moderating Male Midlife Moodiness - The lesser known guy version of menopause is now a ...

Moderating Male Midlife Moodiness

Question: How can you tell if a man has irritable male syndrome?
Answer: You ask him to pass the salt and he yells, "Take, take, take - that's all you ever do!"

Irritable male syndrome (IMS) may sound like a joke, but it's really no laughing matter. Just as women experience anxiety, depression and irritability with hormonal changes, men too can suffer from cyclic and menopausal symptoms-they're just more likely to be chastised for it instead of being consoled with a pint of Ben & Jerry's ice cream.

Since men's hormones actually fluctuate every hour rather than every 28 days, it should come as no surprise that male behavior should be affected. For some men over 40, however, the behavior swing can be quite dramatic, leaving a guy in a chronic bad mood. But try telling the grouch that he suffers from "male menopause" and he just might chuck the Ben & Jerry's at you.

The term "irritable male syndrome" was coined by Gerald A. Lincoln, a researcher at the Medical Research Council's Human Reproductive Sciences Unit in Edinburgh, Scotland. Lincoln first observed IMS while studying Soay sheep, a large, curly-horned variety known for their boisterous rutting rituals that rival the masculine intensity of any Super Bowl party. After mating season, however, Lincoln noticed that as testosterone levels dropped off, the rams became agitated, fearful, withdrawn and likely to irrationally strike out at other males. The hypothesis behind this behavior is that the withdrawal of androgens affects melatonin and serotonin uptake and can make for one cranky ram. However, IMS in two-legged, human subjects can present itself with more complexity.

Psychotherapist Jed Diamond, author of The Irritable Male Syndrome: Managing the Four Key Causes of Depression and Aggression (Rodale Books), defines IMS as "a state of hypersensitivity, anxiety, frustration and anger that occurs in males and is associated with biochemical changes, hormonal fluctuations, and loss of male identity" that can occur at any time during a man's life. A lot of IMS involves depression; normally thought of as a female problem, this emotional downer often comes out differently in men, more outwardly than inwardly directed.

One point of similarity between the sexes is that IMS, like depression in women, is often linked to the multi-source stress that pervades modern living. The result? According to Diamon, "Up to 30% of men, especially those in adolescence and midlife, exhibit symptoms of IMS. In its mildest forms, it can cause men to be moody and irritable. At its worst, it can lead to violence and even suicide."

Is it a Bad Day or a Bad Decade?

So how can you really tell if a man has irritable male syndrome? Since a guy isn't likely to say flat out that he's having trouble with relationships or is having hot flashes (you read that right), there are other, more telltale signs to look for. While we all may temporarily experience bad moods, if you or someone you know exhibits one or more of these feelings with frequency over a period of time, IMS may be the cause: anger, sarcasm, defensiveness, blaming, withdrawal, anxiety, defiance, being argumentative, feeling unappreciated, frustration.

Physical IMS symptoms include fatigue, unexpected weight gain or loss, frequent urination, hair loss (besides the typical male pattern) and impotence. The thyroid gland, which serves as the body's master energy controller, is often out of whack on men suffering from IMS. If that sounds familiar, see your practitioner for a thyroid hormone check.

Less Flabby Means Less Crabby

Sometimes, IMS is not a matter of lowered testosterone levels but one of elevated estradoil, the usable form of the female hormone estrogen. This condition can develop with consumption of too many hormone-laced meats (eating organic meat is a good option). In addition, a diet high in high-glycemic carbs such as white breads and white pasta will undermine testosterone levels as well as pack on unwanted pounds.

To help trim down and keep IMS symptoms at bay, Larrian Gillespie, MD, author of The Gladiator Diet: How to Preserve Peak Health, Sexual Energy, and A Strong Body at Any Age (Healthy Life Publications), recommends a diet that's 40% protein, 35% low-glycemic carbs (read: green veggies) and 25% fat, of which only 10% should be saturated fat. To help keep testosterone levels up, avoid apricots, carrots, white potatoes, white rice (whole wheat past and rise are okay) and-sorry guys-dark beer.

Gillespie also recommends that men take a multivitamin daily along with calcium, magnesium and the herb saw palmetto to inhibit the breakdown of testosterone into dihydrotestosterone a precursor to prostate disease.

Now that you know IMS is real, you can take the bull (or Soay ram) by the horns and do something about it. IMS can be treated through diet, natural hormone replacement therapy and counseling, if necessary.

Question: What do you call a man who is always tired, miserable and irritable?
Answer: Normal.

Wrong answer! That was the old guy. Mr. Nice is back. -Karyn Maier

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Vitanet ®

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Date: July 13, 2005 12:42 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: References

ENDNOTES

1 Time Magazine, (April 6, 1992).
2 Indena Fact Sheet, # 16.
3 The New York Times. (April 25, 1993).
4 Jon J. Mich n ovicz, M.D., Ph.D. H ow to Reduce Your Risk of Breast Cancer, (New York: Warner Books, 1994), 103.
5 Richard A. Passwater Ph.D., Cancer Prevention and Nutritional T h e ra p i e s, (New Canaan, Connecticut: Keats Publishing, 1993).
6 G. Block, University of Southern California at Berkeley
7 “ L e u c o a n t h o c yanins Extract From Grapeseeds (Vins Vinifera),” Indena Publication
8 Liviero, International Symposium on Phytochemistry of Plants Used in Traditional Medicine.
9 R.I. Rayer, and C. L. Schmidt, Seminary Hospital, (Paris: 1981), 57, 2009 and Indena International Report (Data on File). 10 J . F. Thebaut, P. Thebaut and F. Vin, Gazet te Medicale, (1985), 92, 96.
11 L. Fusi, F. Czimeg, F. Pesce, R. Germagli, A. Boero, M. Vanzetti, G. Gandiglio, Ann Ott Clin, Ocul, (1988) 114, 575.
12 D. Zafirov, G. Bredy-Dobreva, V. Litchev, M. Papasovasvie, Ac ta Physiol Pharmacol, Inst i t u te of Phys i o l o g y, Bulgarian Academy of Sciences, (Sofia, Bulgaria: 1990) 16 (3) 50-54.
13 B. Vennet, “Anti-ulcer Activity of Procyanidin Preparation of Wa ter Soluble Pro c yanidin Cimetidine Comp l exes,” Pharm Acta Helv, (Switzerland: 1989), 64 (11) 316-20
14 “Leucoanthocyanins Extract From Grapeseed (Vins Vinfera)” Indena Publication.

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Vitanet ®

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Date: July 11, 2005 05:23 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Immune System - with Kyolic Garlic

The Immune System

The immune system is our body's natural defense system that keeps us healthy. Without it, invading organisms, which we come into contact with constantly, would cause illness and disease. There are many components of the immune system, including natural killer cells, T&B cells, macrophages and many others. Collectively, this network mainly functions against bacteria, viruses, fungi, and parasites.

It is possible for the immune system to be suppressed. Things like stress, unhealthy habits, lack of nutrition, genetics, and other factors damage the immune system, which leaves us vulnerable to disease.

The immune system can benefit from proper, and constant care. A healthy immune system can mean the difference between getting mildly sick versus something much worse. If you are looking for ways to boost your immune system via nutritional supplements, here are a few that might interest you:

Aged Garlic ExtractTM (AGE): Numerous scientific studies have been conducted on AGE in relation to its effect on the immune system. Studies suggest that Aged Garlic Extract may support various immune factors,1-5 such as the ability of immune cells to engulf foreign organisms, T-lymphocyte activity,3 natural killer cell activity1,2 and antibody generation.6 Anti-fungal (Candida albicans-yeast) properties have been shown, and antiviral (herpes1,7, influenza8,9) properties have also been noted. Aged Garlic Extract has also been shown to modify, directly or indirectly, the function of immune cells, which play a leading role in allergic reactions including inflammation.10 In addition, Aged Garlic Extract has been shown to improve age-related deterioration of the immune response.

For your convenience AGE is available as a liquid, and in a capsule, such as the Reserve, FORMULA 100 (tablet or capsule), or as the One Per Day (caplet).

AGE also comes in combination with other herbs and nutrients that may further enhance the immune system. We have formulated a couple of products containing Aged Garlic Extract, specifically for the immune system due to the additional ingredients added that work as an extra boost in this area. Firstly, FORMULA 103 (brown/orange label) in addition to Aged Garlic Extract contains Astragalus, a potent herb demonstrating immune stimulating properties12-17 and vitamin C as Ester-C® (a unique form of Vitamin C) which may support healthy immune function.18 Another product, FORMULA 105 (pink/purple label), contains Vitamins A, C, E, selenium and green tea extract, which are very potent antioxidants. Antioxidants attack free radicals that cause damage to our body, leading to illness and aging. Please keep in mind that the various antioxidant functions attributed to AGE may also help to boost the immune system.

Kyo-Green® is another one of our superb products. Mixing Kyo-Green in a juice or beverage may help to provide extra nutritional support since it is a source of vitamins, minerals, chlorophyll, superoxide dismutase (a very potent anti-oxidant enzyme) and other nutrients. A test tube study by Dr. Lau from Loma Linda University showed that Kyo-Green may provide nutritional support for the immune system by enhancing the activity of macrophages (immune cells that engulf foreign agents).19 Two teaspoons of Kyo-Green also provide the nutrients in a serving of vegetables so this product may function as an easy way to provide extra nutrition for the whole body.

For those who may be interested in a more potent immune boosting formula, please try our Kyo-Green Harvest Blend The Harvest BlendTM contains all of the ingredients in the Kyo-Green, except for the kelp. However, in addition to these ingredients, other active ingredients are added to make forty-four ingredients in total, which may give the immune system a powerful kick. To help support your health there are many different greens, an immune-boosting herbal blend, antioxidant fruits and veggies, immune-enhancing mushrooms, an enzyme active sprout blend, a super energizing blend, special phytonutrients important to immune health, and a nutritious fiber blend. Please read the specifics on each of these constituents, available from the technical information available on this website.

Finally, Kyo-Dophilus® is a probiotic supplement made of a combination of Lactobacillus acidophilus, Bifidobacteria bifidum, and Bifidobacteria longum, which help to maintain a healthy balance of the intestinal microflora and increase our first line of devense in the guy by enhancing macrophages and other immune factors by releasing immune boosting materials. This potent supplement of beneficial bacteria is also ideal for those taking antibiotics, those who are traveling or for those who just want to insure a plethora of beneficial bacteria in their intestinal tracts. Antibiotics are not selective in the bacteria that they kill off. When our friendly bacteria are wiped out, the bad guys have a window of opportunity to take over, as they grow much quicker than our friendly bacteria, and cause us problems. The lactic acid (friendly) bacteria have been shown to produce vitamins, enzymes and antimicrobial compounds that may improve the environment in the intestinal tract. Studies also suggest that friendly bacteria may help to increase resistance to some microbial infections.20-21 Kyo-Dophilus has demonstrated incredible stability at room temperature maintaining more than one billion live cells per capsule through its three-year shelf life. A minimum of one billion live cells per day is considered to be necessary to obtain desired effectiveness from a probiotic supplement. Kyo-Dophilus also comes in tablet form, in a nine-strain formation known as Kyo-Dophilus® 9, and in a smaller form for children, Kid's Kyo-Dophilus®.

Supplying your immune system with adequate nutrition may promote health and ward of illness. If you give the body the tools it needs to heal it-self, it is amazing what it is capable of.

References:


1. Abdullah, T. et al. J. Oncology 21: 52-53, 1989
2. Kandil, O. M. et al. Fed. Proc. 46(3): 441, 1987
3. Lau et al., Mol. Biother. 3:103, 1991
4. Lau, B. et al. Inter. Clin. Nutr. Rev. 9: 27, 1989

5. Morioka, et al. Cancer Immunol. Immunother. 37: 316, 1993
6. Yokoyama, K., Fuwa, T. et al. 1986. Oyo Yakuri (Applied Pharmacology), 31: 977-984.
7. Tsuei, J. Method for treating genital and oral herpes. International Publication Number WO97/03203. International Patent Classification: A61K 35/78, June 4, 1987.
8. Nagai, K. 1973a. Kansenshogaku-Zasshi (Jap. J. Infect. Disease) 47(9): 321-325.
9. Nagai, K. 1973b. Kansenshogaku-Zasshi (Jap. J. Infect. Disease) 47(4): 111-115.
10. Kyo, E., Itakura, Y. 1997. Phytomed. 4(4): 335-340.
12. Chu, D.T. et al. J. Clin. Lab. Immunol. 26(4): 183?187, 1988.
13. Chu, D.T. et al. J. Clin. Lab. Immunol. 25(3): 125?129, 1988.
14. Chu, D.T. et al. J. Clin. Lab. Immunol. 25(3): 119?123, 1988.
15. Wang, Y. et al. Mol Biother 4(3): 143?146, 1992.
16. Rittenhouse, J.R. et al. J Urol 146(2): 486?490, 1991.
17. Sun, Y. et al. Cancer 52(1): 70?73, 1983.
18. Bendich A. Food Tech 41: 112-1124, 1987.
19. Lau, B.H.S. 1992. Int. Clin. Nutr. Rev. 12(3): 147.
20. Honma, N. (1986) New Medicines and Clinics 35(12): 2687-2695.
21. Honma, N. (1974) Pediatric Clinics, 27(11): 20.
22. Yamashita, M., et al. (1987) Clinics and Microorganisms 13(b): 87.

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Date: July 07, 2005 05:04 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Heart Disease - Pollution Connection

Heart disease isn't the illness we usually associate with the health hazard known as pollution, but perhaps it should be. While pollution is strongly (and rightly) linked to cancer in the public mind, officials now realize that airborne junk can gum up the circulatory system. They've even coined a term for it: environmental cardiology.

The main villain is fine particulate matter, present in factory and vehicle emissions. These particals are so small they sift right through the lungs and into the bloodstream. There, fine particulate ignites inflammation, accelerates arterial narrowing, thickens blood and disrupts the heart's pacemaking mechanism. Other airborne pollutants hazardous to the heart include carbon monoxide and sulfur dioxide.

As young as it is, environmental cardiology has already taken some interesting turns. At least 17 of 87 government-monitored water contaminants have been linked to cardiovascular disease. Even more intriguing is the theory that pollution may wreak heart disease during adulthood.

After years on the research fringe, environmental cardiology moved to center stage with the publication of its own American Heart Association Scientific Statement, which concluded the air pollution poses as "Serious public health problem" in terms of heart disease. A pronouncement from such a mainline health group has translated into big bucks for studies. The biggest so far: a $30 Million, 10-year effort, led by the University of Washington, that will evaluate roughly 8700 people for signs of pollution sparked cardiovascular illness.

No one is discounting such traditional heart risk factors as poor diet and insufficient exercise. But the air we breathe is making many of our hearts sick and it's about time big medicine started sitting up and taking notice. --Lisa James....

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Vitanet ®

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Date: June 30, 2005 09:27 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Echinacea - Choosing The Ideal Immune Support

Echinacea By Ellen J. Kamhi, Ph. D. with Dorie Greenblatt Echinacea, pronounced ek-i-NAY-see-a, is one herb that has become a “household” name in the 1990’s. Many refer to it as “Purple Cone Flower” because of its large purple daisy petals, which contain a hard and spiny center cone. These spines probably give the plant its name, since sea animals with spines are called “echinoderms”. Echinacea is indigenous to the U.S., and can be found both growing wild in many areas as well as in cultivated gardens. There are actually nine different species of the plant; two are most popular as remedies: Echinacea angustifolia and Echinacea purpurea. Echinacea has a long history of use by Native Americans, who have utilized the herb for a wide variety of treatments ranging from stings, poisoning, toothaches and swollen glands to colds and sore throats. It has also been touted as an ideal natural remedy for snake bites. In particular, the benefit of Echinacea as a treatment for snake bites brought national attention to the herb in the last half of the 1800’s. Dr. H.F.C. Meyer of Pawnee City, Nebraska first tried to interest Eclectic Physicians (doctors who used natural medicines) to use Echinacea as an herbal remedy for snake bites by volunteering to be bitten by a rattlesnake to prove its effectiveness. Although his dramatic offer was rejected, his enthusiasm and concerted efforts led to renewed interest and investigative studies on Echinacea, resulting in the herb’s emergence as one of the most popular natural plant therapies by the turn of the century.

Extensive studies on Echinacea’s medicinal properties continue to mirror the earlier usages of the herb as experienced by indigenous people. In fact, Echinacea is part of the official materia medica listed in the German Commission E. Monographs, a universally recognized publication reputed to be the official information authority on herbal medicines. The Commission lists a number of medicinal applications for Echinacea as an ideal treatment for such conditions as colds, chronic infections of the respiratory tract and lower urinary tract ailments, as well as topically for chronic ulcerations and slow healing wounds.

Echinacea has been shown to be a potent immune system stimulant. Nature’s Answer® offers an outstanding Echinacea fluid herbal extract formula in a unique blend that contains both Echinacea angustifolia root and Echinacea purpurea whole plant. Fluid extracts that feature both whole plant and root parts in the formula insure that the highest levels of the whole herb’s active constituents are maintained. A further advantage to this kind of supplement lies in its delivery system– liquids are faster to absorb and easier to assimilate by the body than tablets or capsules. Nature’s Answer®’s Echinacea formulas are available in either alcohol-free or organic alcohol forms. In addition, the alcohol-free supplements are also offered in a tasty grape or tangy orange flavor.

Two popular blends featuring Echinacea with other supportive herbs are Immune Boost™ and Re-Zist™. Immune Boost™ combines Echinacea with Wild Indigo and Maitake Mushroom. Re-Zist™ contains Echinacea, Goldenseal, Wild Indigo, Cayenne and Myrrh for potent support.

Echinacea is also recognized for its ability to enhance the resistance of cells to viruses, especially when used after cells have been exposed to colds and flus. As a preventative, formulas such as Nature’s Answer®’s Echinacea/Goldenseal (alcohol-free, organic alcohol) are ideal. This is an excellent supplement for soothing sore throats and helping to shrink swollen glands. An added benefit to the formula is the presence to berberine, the active ingredient in Goldenseal, which provides further wellness enhancement.

Many studies have focused on Echinacea’s possible use for ailments such as psoriasis and early rheumatoid arthritis. The herb also acts as an overall anti-inflammatory tonic. Nature’s Answer®’s Blood Support™ (alcohol-free) combines Echinacea with Dandelion, Licorice and other herbs for an anti-inflammatory effect. Allertone™ (alcohol-free) blends Echinacea with Mullein Leaf to help support the respiratory and sinus areas.

Most herbal practitioners suggest using Echinacea for short-term periods. There has been evidence to suggest that the herb loses its effectiveness when used over longer periods of time. Also, in the case of autoimmune illnesses, some people believe Echinacea may OVER-stimulate the immune system, although there is no solid research to back this contention. Echinacea is probably most effective if used in frequent doses for 5-7 days at the early onset of symptoms. It may also serve as a preventative during periods after known exposure or during extra stress, taking it two to three times a day every other or every third day. The German Commission E lists no known drug interactions or side effects with Echinacea. It is indeed one of the safest and most effective herbs for natural immune support today.

Echinacea seems well suited to life in the 90’s with all the stresses upon our immune systems. Its importance and effectiveness as an immune stimulant is as true today as it was in 1927 when Dr. Liebstein stated:

“Nature has probably destined Echinacea to be used for remedial purposes only, as a sustainer of vitality, an organizer of the defensive powers of the system, to such an extent as to be justly crowned the greatest immunizing agent in the entire vegetable kingdom....” written in 1927 by Dr. A. M. Liebstein (Foster, 1991)

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Date: June 29, 2005 12:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Wellness Herbal Kids Liquid - Immune Support for Children–Ages 2 & Up

For parents, nothing is more important than ensuring the wellbeing of our children. That’s why Source Naturals developed WELLNESS HERBAL KIDS.

WELLNESS HERBAL KIDS is the only herbal liquid for children with the Wellness name behind it. This unique and powerful cold weather blend features the prime immune herbs, echinacea and goldenseal. Unlike typical formulas, WELLNESS HERBAL KIDS also contains the famed Yin Chiao Chinese herbal complex, plus uncommon winter botanicals from around the world. And WELLNESS HERBAL KIDS is alcohol-free, with a great kidapproved taste. Source NaturalsWELLNESS HERBAL KIDS: because nothing is too good for your child.

Echinacea & Goldenseal: Botanical Immune Support

Echinacea, one of the most popular herbs in the United States, has been used to support natural defenses for more than 5,000 years. A highly valued Native American botanical, it has been shown in modern research to support immune function, specifically the activity of macrophages. Echinacea’s beneficial activity is due to a number of constituents, including polysaccharides and echinacosides, a group of compounds found only in echinacea. WELLNESS HERBAL KIDS features a standardized extract of Echinacea purpurea and Echinacea angustifolia. Goldenseal, another Native American botanical, has been used for centuries to soothe sensitive mucous membranes, including those in the respiratory, digestive and genitourinary systems. Its beneficial properties are attributed to its alkaloids, especially berberine.

Yin Chiao: Classic Chinese Formula

According to traditional Chinese herbalism, Yin Chiao is best taken at the first signs of internal imbalance. Yin Chiao features herbs like lonicera (honeysuckle), forsythia, peppermint, and licorice.

Supporting Herbs

WELLNESS HERBAL KIDS includes other traditional botanicals. Elderberry has been used for winter health for centuries. It is a rich source of nutrients, especially bioflavonoids and anthocyanins. The phytonutrients in elderberry positively influence cell function and protection, and support the immune system. Isatis contains glycosides that help support your body’s innate defenses; it is valued by herbalists as a complement to echinacea and goldsenseal. The formula also includes the traditional Native American botanicals boneset and horehound, warming ginger, the renowned adaptogen Eleutherococcus senticosus, and bayberry.

The Wellness Family™:

Comprehensive Winter Support WELLNESS HERBAL KIDS, an important member of Source Naturals’ Wellness Family of natural immune system products, is available in 2, 4 and 8 fl oz bottles. You can also try Source Naturals’ other fine Wellness products. Look for WELLNESS EARACHE™ homeopathic kids’ formula, WELLNESS COLD & FLU™, WELLNESS COUGH SYRUP, WELLNESS ZINC™ Lozenges and Throat Spray, WELLNESS ELDERBERRY™ and lots more—including, of course, original WELLNESS FORMULA®.

WELLNESS HERBAL KIDS: Part of the Wellness Revolution

There is a revolution underway in natural health consciousness, and health food stores are in the forefront. You can benefit right now—long before word spreads to the general public—with the innovative child nutrition of WELLNESS HERBAL KIDS.

References:
Bensky, Dan & Barolet, Randall, compilers/translators. Chinese Herbal Medicine: Formulas & Strategies. Seattle: Eastland Press; 1990; pp. 44-46. Pizzorno, Joseph E., N.D. & Murray, Michael T., N.D. A Textbook of Natural Medicine. Seattle: John Bastyr College Publications; 1987. V. 2: Echin 1-2, V. 2: Hydras 1-4.

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Vitanet ®

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Date: June 25, 2005 08:13 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: REFERENCES

REFERENCES

1 a. The Surgeon General’s “Nutrition and Health Report.” b. The Centers for Disease Control and Prevention’s “National Health and Examination Survey (NHANES III)” c. The National Academy of Science’s. Diet and Health Report: Health Promotion and Disease Objectives (DHHS Publication No. (PHS) 91-50213, Washington, DC: US Government Printing Office, 1990). e. Dietary Guidelines for Americans. 2 Rolls BJ. Carbohydrates, fats, and satiety. Am J Clin Nutr 1995; 61(4 Suppl):960S-967S. 3 McDowell MA, Briefel RR, Alaimo K, et al. Energy and macronutrient intakes of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1:1988-91. Advance data from vital and health statistics of the Centers for Disease Control and Prevention; No. 255. Hyattsville, Maryland: National Center for Health Statistics; 1994. 4 Center for Science in the Public Interest and McDonald’s Nutrition and You—A guide to Healthy Eating at McDonald’s: McDonald’s Corp,1991. 5 Bray GA. Appetite Control in Adults. In: Fernstrom JD, Miller GD eds. Appetite and Body Weight Regulation. Boca Raton: CRC Press, 1994:1-92. 6 Michnovicz JJ. How to Reduce Your Risk of Breast Cancer. New York: Warner Book Inc. 1994:54. 7 Carcinogens and Anticarcinogens in the Human Diet. National Research Council Report, National Academy of Sciences, 15 Feb. 1996. 8 Van Tallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979:32: 2723-33. 9 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:273. 10 Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16A-hydroxyestrone to estradiol in human breast concer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1988:85;7831-5. 11 Colditz GA. Epidemiology of breast cancer. Findings from the nurses’ health study. Cancer1993;714:1480-9. 12 Hennen WJ. Breast Cancer Risk Reduction. The effects of supplementation with dietary indoles. Unpublished report 1992. 13 Deslypere BJ. Obesity and cancer. Metabolism 1995;44(93):24-7. 14 Somer E, M.A. R.D. Nutrition for Women. New York: Henry Hold and Company, 1993:281. 15 Whittemore AS, Kolonel LN, John M. Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst 1995;87(9):629-31. 16 Key T. Risk factors for prostate cancer. Cancer Survivor 1995;23:63- 77. 17 Kondo Y, Homma Y, Aso Y, Kakizoe T. Promotional effects of twogeneration exposure to a high-fat diet on prostate carcinogenisis in ACI/Seg mice. Cancer Res 1994;54(23):6129-32. 18 Wang Y, Corr JG, Taler HT, Tao Y, Fair WR, Heston WD. Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet. J Natl Cancer Inst. 1995;87(19):1456-62. 19 Nixon DW. Cancer prevention clinical trials. In-Vivo 1994;8(5):713-6. 20 Key T. Micronutrients and cancer aetiology: the epidmiological evidence. Proceed Nutr Soc 1994;53(3):605-14. 21 Gorbach SL, Goldin BR. The intestinal microflora and the colon cancer connection. Reviews of Infectious Diseases 1990;12(Suppl 2):S252-61. 22 Shrapnel WS, Calvert GD, Nestel PJ, Truswell AS. Diet and coronary heart disease. The National Heart Foundation of Australia. Med J Australia. 1995;156(Suppl):S9-S16. 23 Ellis JL, Campos-Outcalt D. Cardiovascular disease risk factors in native Americans: a literature review. Am. J. Preventive Med 1994;10(5):295-307. 24 DiBianco R. The changing syndrome of heart failure: an annotated review as we approach the 21st century. J. Hypertension 1994; 12(4 Suppl):S73- S87. 25 Van Itallie TB. Obesity: adverse effects on health and longevity. Am J Clin Nutr 1979;32(suppl):2723-33. 26 Kestin M, Moss R, Clifton PM, Nestel PJ. Comparative effects of three cereal brans on plasma lipids, blood pressure and glucose metabolism in mildly hyper-cholesterolemic men. Am J Clin Nutr 1990;52(4):661-6. 27 Story JA. Dietary fiber and lipid metabolism. In: Spiller GA, Kay RM. eds. Medical Aspects of Dietary Fiber. Penun Medical; New York, 1980, p.138. 28 Stein PP, Black HR. The role of diet in the genesis and treatment of hypertension. Med. Clin. North America. 1993;77(4):831-47. 29 Olin JW. Antihypertensive treatment in patients with peripheral vascular disease. Cleve. Clin. J. Medicine. 1994;61(5):337-44. 30 Tinker LF. Diabetes Mellitus—a priority health care issue for women. J. Am. Dietetic Association. 1994;94(9):976-85. 31 Gaspard UJ, Gottal JM, van den Brule FA. Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas. 1995;21(3):71-8. 32 Coordt MC, Ruhe RC, McDonald RB. Aging and insulin secretion. Proc. Soc. Exp. Biology and Medicine. 1995;209(3):213-22. 33 Felber JP. From Obesity to Diabetes. Pathophysiological Considerations. Int. Journal of Obesity 1992;16:937-952. 34 Gillum RF. The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes, and cardiovascular risk factors in men and women age 18-79. J Chronic Diseases 1987;40:421-8. 35 Haffner SM, Stern MP, Hazuda HP, et al. Role of obesity and fat distribution in non-insulin-dependent diabetes mellits in Mexican Americans and non- Hispanic whites. Diabetes Care 1986;9:153-61. 36 Bonadonna RC, deFronzo RA. Glucose metabolism in obesity and type 2 diabetes. Diabetes and Metabolism. 1991;17(1 Pt. 2):12-35. 37 Shoemaker JK, Bonen A. Vascular actions of insulin in health and disease. Canadian J. of Applied Physiology. 1995;20(2):127-54. 38 Resnick LM. Ionic Basis of Hypertension, Insulin Resistaince, Vascular Disease, and Related Disorders. The Mechanism of ‘Syndrome X’. Am. J. Hypertension. 1993;6(suppl):123S-134S. 39 Trautwein EA. Dietetic influences on the formation and prevention of cholesterol gallstones. Z. Ernahrugswiss. 1994;33(1):2-15. 40 Cicuttini FM, Spector TD. Osteoarthritis in the aged. Epidemiological issues and optimal management. Drugs and Aging. 1995;6(5):409-20. 41 Melnyk MG, Wienstein E. Preventing obesity in black women by targeting adolescents: a literature review. J Am. Diet. Association. 1994;94(4):536-40. 42 Robinson BE, Gjerdingen Dk, Houge DR. Obesity: a move from traditional to more patient-oriented management. J. Am. Board of Family Practice. 1995;8(2):99-108. 43 Dulloo AG, Miller DS. Reversal of Obesity in the Genetically Obese fa/fa Zucker Rat with an Ehpedrine/Methylxanthines Thermogenic Mixture. J. Nutrition. 1987;117:383-9. 44 Dulloo AG, Miller DS. The thermogenic properties of ephedrin/methylxanthine mixtures: animal studies. Am J Clinical Nutr. 1986;43:388-394. 45 Richelsen B. Health risks of obesity. Significance of the regional distri-bution of adipose tissue. Ugeskr. Laeger. 1991;153(13):908-13. 46 Lissner L, Heitmann BL. Dietary fat and obesity: Evidence from epidemiology. European J. Clinical Nutrition. 1995;49(2):79-90. 47 Lissner L, Heitmann BL. The dietary fat: Carbohydrate ratio in relation to body weight, Current Opinion in Lipidology. 1995;6(1):8-13. 48 Ravussin E. Energy metabolism in obesity. Studies in the Pima Indians. Diabetes Care. 1993;16(1):232-8. 49 O’Dea K. Westernisation, insulin resistance and diabetes in Australian aborigines. Med J. Australia. 1991;155(4):258-64. 50 Bailey C. Fit or Fat . Houghton Mifflen, Boston, 1991. 51 McCarty MF. Optimizing Exercise for Fat Loss. Unpublished report. 52 Weinsier RL, Schutz Y, Bracco D. Reexamination of the relationship of resting metabolic rate and fat-free mass and the the metabolically active components of fat-free mass in humans. Am. J. Clinical Nutrition. 1992;55(4):790-4. 53 Evans WJ. Exercise, nutrition and aging. J. Nutrition. 1992;122(3 suppl):796-801. 54 Schlicker SA, Borra ST, Regan C. The weight and fitness status of United States children. Nutrition Reviews. 1994;52(1):11-7. 55 Raben A, Jensen ND, Marckmann P, Sandstrom B and Astrup A. Spontaeous weight loss during 11 weeks’ ad libitum intake of a low fat/high fiber diet in young, normal weight subjects. Stockholm Press. 1995;916-23. 56 Blundell JE, Cotton JR, Delargy H, Green S, Greenough A, King NA, Lawton, CL. The fat paradox: fat-induced satiety signals versus high fat overconsumption. Short Communication 1995:832-835. 57 Reinhold RB. Late results of gastric bypass surgery for morbid obesity. J Am Coll Nutr 1994;13(4):307-8. 58 McCredie M, Coates M Grulich A. Cancer incidence in migrants to New South Wales (Australia) from the Middle East, 1972-1991. Cancer Causes Control 1994:5(5):414-21. 59 Schiff ER, Dietschy JM. Steatorrhea Associated with Disordered Bile Acid Metabolism. Am. J. Digestive Diseases. 1969;14(6) 60 Nauss JL , Thompson JL and Nagyvary J. The binding of micellar lipids to Chitosan. Lipids. 1983;18(10):714-19. 61 Braconnot H, Sue la natrue ces champignons. Ann Chim Phys 1811;79:265. 62 Odier A. Memoire sur la composition chemique des parties cornees des insectes. Mem Soc Hist Nat Paris 1823;1:29. 63 Johnson EL, Peniston QP. Utilization of shellfish waste for chitin and Chitosan production. Chp 19 In: Chemistry and Biochemistry of Marine Food Products. Martin RE, Flick GJ, Hebard CE and Ward DR (eds.) 1982. p.415-. AVI Publishing Co., Westport, CT. 64 Shahram H. Seafood waste: the potential for industrial use. Kem Kemi 1992;19(3),256-8. 65 Rouget C. Des substances amylacees dans le tissue des animux, specialement les Articules (Chitine). Compt Rend 1859;48:792. Commission on Natural Health Products. 1995 67 Peniston QP and Johnson EL. Method for Treating an Aqueous Medium with Chitosan and Derivatives of Chitin to Remove an Impurity. US Patent 3,533,940. Oct. 30:1970. 68 Poly-D-Glucosamine (Chitosan); Exemption from the Requirement of a Tolerance. Federal Register. 1995;60(75):19523-4. Rules and Regulations. Environmental Protection Agency 40 CFR Part 180. April, 19, 1995. 69 Arul J. “Use of Chitosan films to retard post-harvest spoilage of fruits and vegetables,” Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 70 Karlsen J, Skaugrud O. “Excipient properties of Chitosan,” Manufacturing Chemist. 1991;62:18-9. 71 Winterowd JG, Sandford PA. Chitin and Chitosan. In: Food Polysaccharides and their Applications. Ed: Stephen AM. Marcel Dekker 1995. 72 Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 73 Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 74 Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 75 Zikakis, JP. Chitin, Chitosan and Related Enzymes. Academic Press, Inc. 1984. 76 Abelin J and Lassus A. Fat binder as a weight reducer in patients with moderate obesity. ARS Medicina, Helsinki, Aug- October, 1994. 77 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Increasing effect of a Chitosan and ascorbic acid mixture on fecal dietary fat excretion. Biosci Biotech Biochem 1994;58(9):1617-20. 78 Maezaki Y, Tsuji K, Nakagawa Y, et al. Hypocholesterolemic effect of Chitosan in adult males. Biosci Biotchnol Biochem1993;57(9):1439-44. 79 Kobayashi T, Otsuka S, Yugari Y. Effect of Chitosan on serum and liver cholesterol levels in cholesterol-fed rats. Nutritional Rep. Int., 1979;19(3):327-34. 80 Sugano M, Fujikawa T, Hiratsuji Y, Hasegawa Y. Hypocholesterolemic effects of Chitosan in cholesterol-fed rats. Nutr Rep. Int. 1978;18(5):531-7. 81 Vahouny G, Satchanandam S, Cassidy M, Lightfoot F, Furda I. Comparative effects of Chitosan and cholestryramine on lymphatic absorption of lipids in the rat. Am J Clin Nutr, 1983;38(2):278-84 82 Suzuki S, Suzuki M, Katayama H. Chitin and Chitosan oligomers as hypolipemics and formulations containing them. Jpn. Kokai Tokkyo Koho JP 63 41,422 [88,422] 22 Feb1988. 83 Ikeda I, Tomari Y, Sugano M. Interrelated effects of dietary fiber on lymphatic cholesterol and triglyceride absorption in rats. J Nutr 1989;119(10):1383- 7. 84 LeHoux JG and Grondin F. Some effects of Chitosan on liver function in the rat. Endocrinology. 1993;132(3):1078-84. 85 Fradet G, Brister S, Mulder D, Lough J, Averbach BL. “Evaluation of Chitosan as a New Hemostatic Agent: In Vitro and In Vivo Experiments In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 86 Malette W, Quigley H, Gaines R, Johnson N, Rainer WG. Chitosan A New Hemostatic. Annals of Thorasic Surgery. 1983;36:55. 87 Malette W, Quigley H, Adickes ED. Chitosan effect in Vascular Surgery, Tissue Culture and Tissue Regeneration. In R Muzzarelli, C Jeuniaux, GW Gooday, Eds: Chitin in Nature and Technology. Plenum Press, New York. 1986. 88 Okamoto Y, Tomita T, Minami S, et al. Effects of Chitosan on experimental abscess with Staphylococcus aureus in dogs. J. Vet. Med., 1995;57(4):765-7. 89 Klokkevold PR, Lew DS, Ellis DG, Bertolami CN. Effect of Chitosan on lingual hemostasis in rabbits. Journal of Oral-Maxillofac-Surg, 1991;Aug. 49(8):858-63. 89 Surgery, Tissue Culture and Tissue Regeneration. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 90 Hiroshi S, Makoto K, Shoji A, Yoshikazu S. Antibacterial fiber blended with Chitosan. Sixth International Conference on Chitin and Chitosan. Sea Fisheries Institute, Gdynia, Poland. August 1994;16-19. 91 Shimai Y, Tsukuda K, Seino H. Antiacne preparations containing chitin, Chitosan or their partial degradation products. Jpn. Kikai Tokkyo Koho JP 04,288,017 [92,288,017] 13 Oct 1992. 92 Suzuki K, Okawa Y, Suzuki S, Suzuki M. Candidacidal effect of peritoneal exudate cells in mice administered with chitin or Chitosan: the role of serine protease in the mechanism of oxygen-independent candidacidal effect. Microbiol Immunol. 1987;31(4):375-9. 93 Sawada G, Akaha Y, Naito H, Fujita M. Synergistic food preservatives containing organic acids, Chitosan and citrus seed extracts. Jpn, Kokai Kokkyo Koho JP 04 27,373 [92 27,373] 30 Jan 1992. 94 Min H-K, Hatai K, Bai S. Some inhibitory effects of Chitosan on fishpathogenic oomycete, Saprolegnia parasitic. Gyobyo Kenkyu, 1994;29(2):73-4. 95 Nelson JL, Alexander JW, Gianotti L, Chalk CL, Pyles T. The influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutr 1994;10(1):32-6. 96 Ochiai Y, Kanazawa Y. Chitosan as virucide. Jpn Kokai Tokkyo Koho 79 41,326. 97 Hillyard IW, Doczi J, Kiernan. Antacid and antiulcer properties of the polysaccharide Chitosan in the rat. Proc Soc Expl Biol Med 1964; 115:1108-1112. 98 Shibasaki K, Sano H, MatsukuboT, Takaesu Y. pH response of human dental plaque to chewing gum supplemented with low molecular Chitosan. Bull- Tokyo-Dent-Coll, 1994:35(2): 61-6. 99 Kato H, Okuda H. Chitosan as antihypertensive. Jpn. Kikoi Tokyo Koho JP 06 56,674 [94 56,674] 100 Kato H, Taguchi T. Mechanism of the rise in blood pressure by sodium chloride and decrease effect of Chitosan on blood pressure. Baiosaiensu to Indasutori 1993;51(12):987-8. 101 Muzzarelli R, Biagini G, Pugnaoni A, Filippini O, Baldassarre V, Castaldini C, and Rizzoli C. Reconstruction of Periodontal Tissue with Chitosan. Biomaterials. 1989;10:598-603. 102 Sapelli P, Baldassarre V, Muzzarelli R, Emanuelli M. Chitosan in Dentistry. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 103 Borah G, Scott G, Wortham K. Bone induction by Chitosan in endochrondral bones of the extremities. In Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 104 Ito F. Role of Chitosan as a supplementary food for osteoporosis. Gekkan Fudo Kemikaru, 1995;11(2):39-44. 105 Nakamura S, Yoshioka T, hamada S, Kimura I. Chitosan for enhancement of bioavailability of calcium. Jpn. Kokai Tokkyo Koho JP 07 194,316 [95 194,316] 01 Aug 1995. 106 Maekawa A, Wada M. Food Containing chitin or its derivatives for reduction of blood and urine uric acid. Jpn. Kokai Tokkyo Koho JP 03 280,852 [91 280,852], 11 Dec 1991. 107 Weisberg M, Gubner R. Compositions for oral administration comprising Chitosan and a pharmaceutically acceptable carrier. Antacid preparations for alleviating gastric hyperacidity. U.S. patent 3257275 108 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Mechanism for the inhibition of fat digestion by Chitosan and for the synergistic effect of ascorbate. Biosci Biotech Biochem1995;59(5):786-90. 109 McCausland CW. Fat Binding Properties of Chitosan as Compared to Other Dietary Fibers. Private communication. 24 Jan1995. 110 Deuchi K, Kanauchi O, Imasato Y, Kobayashi E. Biosci Biotech Biochem. 1994:58,1613-6. 111 Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 1989;119(8):1100-6. 112 Weil A, M.D. Natural Health Natural Medicine: Boston: Houghton Mifflin, 1990:182. 113 Chen Y-H, Riby Y, Srivastava P, Bartholomew J, Denison M, Bjeldanes L. Regualtion of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells. J Biol Chem 1995;270(38):22548-55. 114 Intestinal Absorption of metal ions and chelates. Ashmead HD, Graff DJ, Ashmead HH. Charles C Thomas, Springfield, IL 1985. 115 Nutrient Interactions. Bodwell CE, Erdman JW Jr. Marcel Dekker New York 1988. 116 Heleniak EP, Aston B. Prostaglandins, Brown Fat and Weight Loss. Medical Hypotheses 1989;28:13-33. 117 Connor WE, DeFrancesco CA, Connor SL. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann NY Acad Sci 1993;683:16-34. 118 Conte AA. A non-prescription alternative in weight reduction therapy. The Bariatrician Summer 1993:17-19. 119 McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Unpublished manuscript. 120 Bray GA. Weight homeostasis. Annual Rev Med 1991;42:205-216. 121 Dulloo AG, Miller DS. The thermogenic properties of Ephedrin/Methylxanthine mixtures: Human studies. Intl J Obesity 986;10:467-481. 122 Arai K, Kinumaki T, Fujita, T. Bulletin Tokai Regional Fisheries Res Lab. 1968;No. 56. 123 Bough WA. Private communication. 124 Freidrich EJ, Gehan, EA, Rall DP, Schmidt LH, Skipper HE. Cancer Chemotherapy Reports 1966;50(4):219-244. 125 A Drovanti, AA Bignamini, AL Rovati. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebo-controlled double-blind investigation. Clinical Therapeutics 1980;3(4):260-272. 126 K Deuchi, O Kanauchi, M Shizukuishi, E Kobayashi. Continuous and massive intake of Chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet. Biosci. Biotech. Biochemistry. 1995;59(7):1211-6. 127 . BesChitin W in Chitin Wound Healing (video), Unitika Corporation, April 1992.

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Date: June 24, 2005 04:34 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: References

References

1Claire Kowalchik and William H. Hylton, Editors, Rodale’s Illustrated Encyclopedia. (Emmaus, Pennsylvania: Rodale Press, 1987), 176. 2Louise Tenney, “Echinacea”, To day’s Herbs. ( Provo, Utah: Woodland Publishing, Vol. XIII, Number 1, 1993), 1. 3Family Guide to Na t u ral Medicine. ( Pleasantville, New Yo rk : Reader’s Digest, 1993), 303. 4Andrew Weil, MD, Natural Health, Natural Medicine. (Boston: Houghton Mifflin Company, 1990) 236. 5Gary Gillum, Editor, “Echinacea” To day’s Herbs. ( Provo, Utah : Woodland Books, Vol. I Issue 11, July, 1981), 1. 6PenelopeOdy, The Complete Medicinal Herbal. ( New York : Dorling-Kindersley, 1993), 53. 7Michael Murray, ND and Joseph Pizzorno, ND, Encyclopedia of Natural Medicine. (Rocklin, California: Prima Publishing, 1991), 58. 8V.H. Wagner and A. Proksch., “Immunostimulatory Drugs of Fungi and Higher Plants”, Economic Medicinal Plant Research . (1985), 1, 113-53. 9Louise Tenney, The Encyclopedia of Natural Remedies. ( Pleasant Grove, Utah: Woodland Publishing, 1995), 50. 10Ibid. 1 1Daniel B. Mowre y, The Scientific Validation of Herbs. ( New Canaan, Connecticut: Keats Publishing, 1986), 119. 12Murray, 59. 13Michael T. Murray, N.D.. The Healing Power of Herbs. (Rocklin, California: Prima Publishing, 1995), 100. 14J. Mose, “Effect of Echinacin on Phagocytosis and Natural Killer Cells”, Med. Welt. (1983), 34, 1,463-7. 1 5M. Stimple, A. Proksch, H. Wagner, etal., “Macrophage Activation and Induction of Macrophage Cytotoxicity by Purified Polysaccharide Fractions From the Plant Echinacea Purpurea”, Infection Immunity. (1984), 46, 845-9. 16Mowrey, 119. 17Ibid., 250 18Ibid., 119 19Ibid. 20Ody, 176 21Velma J. Keith and Monteen Gordon, The How To Herb Book. (Pleasant Grove, Utah: Mayfield Publishing, 1983), 29. 2 2Louise Tenney, To day’s Herbal Health. ( Pleasant Grove, Utah: Woodland Publishing, 1992), 60. 2 3Daniel B. Mow re y, Ph.D., Echinacea. ( New Canaan, Connecticut: Keats Publishing, 1995), 31. 24Ibid., 33. 25Ibid., 41. 26C. Steinmuller, J. Roesler, E. Grottrup, G. Franke, H. Wagner and Matthes Lohmann, “Polysacharides Isolated From Plant Cell Cultures of Echinacea Purpurea Enhance the Resistance of Immunosupproes Mice Against Systemic Infections with Candida Albicans and Listeria Monicytogens,” Int-J-Immunpharmacol. 1993, July: 15(5): 605-14. 27Ibid., 43. 2 8U. Mengs, C. Clare and J. Poiley, “Toxicity of Echinacea Purpurea. Acute, Subacute and Genotoxicity Studies , Arzneimittelforschung. 1991, Oct. 41(10): 1076-81.

ADDITIONAL REFERENCES

Becker, V. H. Against snakebites and influenza: use and components of echinacea angustifolia and e. purpurea.. Deutsche Apotheker Zeitung, 122 (45), 1982, 2020-2323. Buesing, K.H. Inhibition of hyaluronidase by echinacin. Arzneimittel- Forschung. 2, 1952, 467-469. Foster, S. Echinacea, Nature’s Immune Enhancer. Healing Arts Press, Rochester, VT., 1991. Hobbs, C. The Echinacea Handbook. Eclectic Medical Publications, Portland, Oregon, 1989. Keller, H. Recovery of active agents from aqueous extracts of the species of echinacea. Chemie Gruenenthal G.M.B.H., GER. Oct . 11, 1956, 950, 674. Kuhn, O. Echinacea and Phagocytosis. Arzneimittel - Fo rxchung, 3, 1953, 194-200. Mc Gregor R.L. The taxonomy of the genus Echinacea (Compositae). Univ. Kansas Sci. Bull. 48, 1968, 113-142.

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Date: June 24, 2005 01:13 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: History

HISTORY

Because 20th century medical practices have routinely over - prescribed antibiotics, the notion of a natural antibiotic with virtually no side-effects is intriguing to say the least. Echinacea is one of several herbs which possesses antibacterial, antiviral and antifungal properties. In a time when new life-threatening microbes are evolving and pose the threat of modern-day plagues, herbs such as echinacea are particularly valuable. More and more health practitioners are focusing on fortifying the immune system to fight off potential infections rather than just treating infection after it has developed.

Echinacea is enjoying a renaissance today. During the late 1980’s, echinacea re-emerged as a remarkable medicinal plant. In addition to its infection fighting properties, echinacea is known for its healing properties as well. As was the case with so many herbs, echinacea lost its prestige as a medicinal treatment with the advent of antibiotics. It has experienced a resurgence over the last two decades.

Echinacea has several other much more romantic names including Purple Coneflower, Black Sampson and Red Sunflower. It has also become the common name for a number of echinacea species like E. angustifolia, E. purpurea, and E. pallida. The genus derives its name from the Greek word echinos which refers to sea urchin. This particular association evolved from the prickly spiny scales of the seed head section of the flower. Historically, echinacea has sometimes become confused with Parthenium integrifolium.

The word echinacea is actually apart of the scientific latin term, echinacea angustifolia, which literally translated means a narrow - leafed sucker. The plant grows wild as a perennial exclusively in the midwestern plains states, but can be cultivated almost anywhere . Echinacea leaves are pale to dark green, coarse and pointy. Its florets are purple and its roots, black and long.

Echinacea has a strong Native American link in the Central Plains. Native Americans are credited with discovering the usefulness of this botanical without knowing its specific chemical properties. It was routinely used by Na t i ve Americans to treat toothaches, snakebite, fevers and old stubborn wounds.

Native Americans thought of echinacea as a versatile herb that not only helped to fight infection, but increased the appetite and s t rengthened the sexual organs as well. The juice of the plant was used to bathe burns and was sprinkled on hot coals during traditional “sweats” used for purification purposes. It is also believed that some Native Americans used echinacea juice to protect their hands, feet and mouths from the heat of hot coals and ceremonial fires.1 According to Melvin Gilmore, An American anthropologist who studied Native American medicine in the early part of this century, Echinacea was used as a remedy by Native Americans more than any other plant in the central plains area.

In time, early white settlers learned of its healing powers and used the plant as a home remedy for colds, influenza, tumors, syphillis, hemorrhoids and wounds. Dr. John King, in his medical journal of 1887 mentioned that echinacea had value as a blood purifier and alterative. It was used in various blood tonics and gained the reputation of being good for almost every conceivable malady. It has been called the king of blood purifiers due to its ability to improve lymphatic filtration and drainage. In time, echinacea became popular with 19th century Eclectics, who were followers of a botanic system founded by Dr. Wooster Beech in the 1830’s. They used it as an anesthetic, deodorant, and stimulant.

By 1898, echinacea had become one of the top natural treatments in America. During these years, echinacea was used to treat fevers, malignant carbuncles, ulcerations, pyorrhea, snake bites and dermatitis. In the early twentieth century, echinacea had gained a formidable reputation for treating a long list of infectious disease ranging from the commonplace to the exotic. The Lloyd Brothers Pharmaceutical House developed more sophisticated versions of the herb in order to meet escalating demands for echinacea.

Ironically, it was medical doctors who considered echinacea more valuable than eclectic practitioners. Several articles on echinacea appeared from time to time in various publications. Its attributes we re re v i ewed and, at times, its curative abilities ranged from the sublime to the ridiculous. In 1909, the Council on Pharmacy and Chemistry of the American Medical Association decided against recognizing echinacea as an official drug, claiming that it lacked scientific credibility. It was added to the National Formulary of the United States despite this type of negative reaction and remained on this list until 1950.

Over the past 50 years, echinacea has earned a formidable reputation achieving worldwide fame for its antiviral, antifungal and antibacterial actions. Consumer interest in echinacea has greatly increased, particularly in relation to its role in treating candida, chronic fatigue syndrome, AIDS and malignancies. Practitioners of natural medicine in Eu rope and America have long valued its attributes. In recent, years, German research has confirmed its ability to augment the human immune system. Extensive research on echinacea has occurred over the last twenty years. Test results have s h own that the herb has an antibiotic, cortisone-like activity.

Echinacea has the ability to boost cell membrane healing, protect collagen, and suppress tumor growth. Because of its immuno-enhancing activity, it has recently been used in AIDS therapy. Research has proven that echinacea may have p rofound value in stimulating immune function and may be particularly beneficial for colds and sore throats.3

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Date: June 23, 2005 11:50 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: ENDNOTES

ENDNOTES

1 G.A. Cordell and O.E. Araujo, “Capsaicin: Identification, nomenclature, and pharmacotherapy.” Ann. Pharmacother. 27: 1993, 330-336.
2 A.Y. Leung. Encyclopedia of Common Natural Ingredients used in Food. (John Wiley and Sons, New York: 1980.
3 Cordell, 330-36.
4 J.J. Jang, D.E. Defor, D.L. Logsdon and J.M. Ward. “A 4-week feeding study of ground red chile (Capsicum annuum) in male mice.” F o o d - C h e m - T o x i c o l . S e p t . 1992 30 (9): 783-7.
5 John R. Christopher. Capsicum. (Christopher Publications, Springville, Utah: 1980), 27.
6 Jack Ritchason. The Little Herb Encyclopedia, 3rd ed. (Woodland Publishing, Pleasant Grove, Utah: 1994), 44.
7 Christopher, 4.
8 Juliette Bairacli-Levy. Common Herbs for Natural Health. (Schocken Books, New York: 1974), 41-43.
9 Charles B. Heiser. Nightshades. (W.H. Freeman, San Francisco: 1969), 18.
10 Lenden H. Smith, M.D., E.P. Donatelle, M.D., Vaughn Bryant, Ph.D. et al. Basic Natural Nutrition. (Woodland Books, Pleasant Grove, Utah: 1984), 157.
11 J. Jurenitsch et al. “Identification of cultivated taxa of Capsicum: taxonomy, anatomy and composition of pungent principle.” Chemical Abstracts. 91 July 30, 1977: 35677g.
12 Daniel B. Mowrey. The Scientific Validation of Herbal Medicine. (Keats Publishing, New Canaan, Connecticut: 1986), 159.
13 Ibid., 208-09.
14 Michael T. Murray. The Healing Power of Herbs, 2nd ed. (Prima Publishing, Prima, California: 1995), 71.
15 J. De Lille and E. Ramirez. “Pharmacodynamic action of the active principles of chile (capsicum annuum L.) Anales Inst. Biol. 1935: 6, 23-37. See also C.C. Toh, T.S. Lee et al. “The pharmacological actions of capsaicin and its analogues.” B r i t i s h Journal of Pharmacology. 1955: 10, 175-182.
16 N.A. Castle. “Differential inhibition of potassium currents in rat ventricular myocytes by capsaicin.” Cardiovasc-Res. Nov. 1992, 26 (11): 1137-44.
17 Murray, The Healing Power of Herbs, 72.
18 Ritchason, 46.
19 T. Kawada, et al. “Effects of capsaicin on lipid metabolism in rates fed a high fat diet.” Journal of Nutrition. 1986: 116, 1272-78. See also J.P. Wang, et al. “Antiplatelet effect of capsaicin.” Thrombosis Res. 1984: 36, 497-507, and S. Visudhiphan, et al. “The relationship between high fibrinolytic activity and daily capsicum ingestion in Thais.” American Journal of Clinical Nutrition. 1982: 35, 1452-58.
20 K. Sambaiah and N. Satyanarayana. “Hpocholesterolemic effect of red pepper and capsaicin.” Indian Journal of Experimental Biology. 1980: 18, 898-99. See also M.R. Srinivasan, et al. “Influence of red pepper and capsaicin on growth, blood constituents and nitrogen balance in rats.” Nutrition Reports International. 1980: 21 (3): 455-67.
21 Mowrey, 12.
22 Ibid.
23 Toh, 175-182.
24 Mowrey, 12.
25 Ibid., 19-20.
26 Louise Tenney. The Encyclopedia of Natural Remedies. (Woodland Publishing, Pleasant Grove, Utah: 1995), 42. See also Peter Holmes. The Energetics of Western Herbs. (Artemis Press, Boulder: 1989), 322.
27 Y. Lee, et al. “Flavonoids and antioxidant activity of fresh pepper (Capsicum annuum) cultivars.” Journal of Food Science. May 1995: 60 (3): 473-76. See also L.R. Howard, et al. “Provitamin A and ascorbic acid content of fresh pepper cultivars (Capsicum annuum) and processed jalapenos.” Journal of Food Science. M a r c h , 1994: 59 (2): 362-65.
28 J.J. Espinosa-Aguirre, et al. “Mutagenic activity of urban air samples and its modulation by chile extracts.” Mutat-Res. Oct. 1993: 303 (2): 55-61.
29 Ibid.
30 Howard, 362-65.
31 Z. Zhang, S.M. Hamilton, et al. “Inhibition of liver microsomal cytochrome P450 activity and metabolism of the tobacco-specific nitrosamine NNK by capsaicin and ellagic acid.” Anticancer-Res. Nov-Dec. 1993: 13 (6A): 2341-46.
32 C.H. Miller, Z. Zhang, et al. “Effects of capsaicin on liver microsomal metabolism of the tobacco-specific nitrosamine NNK.” Cancer-Lett. Nov. 30, 1993: 75 (1): 45- 52.
33 Murray, The Healing Power of Herbs, 71.
34 Cordell, 330-36. See also Murray, The Healing Power of Herbs, 70-71.
35 Murray, The Healing Power of Herbs, 72.
36 C.P.N. Watson, et al. “The post-mastectomy pain syndrome and the effect of topical capsaicin.” Pain. 1989: 38, 177-86. See also C.P.N. Watson and R.J. Evans. “The post-mastectomy pain syndrome and topical capsaicin: A randomized trial.” Pain. 1992: 51, 375-79.
37 Murray, The Healing Power of Herbs, 73.
38 Watson, 177-86.
39 C. Nelson. “Heal the burn: Pepper and lasers in cancer pain therapy.” Journal of the National Cancer Institute. 1994: 86, 1381.
40 Ibid.
41 “The capsaicin study group: Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy.” Diabetes Care. 1992: 15, 159-65. See also R. Tanden, et al. “Topical capsaicin in painful diabetic neuropathy. Effect on sensory function.” Diabetes Care. 1992: 15, 8-14, K.M. Basha and F.W. Whitehouse. “Capsaicin: A therapeutic option for painful diabetic neuropathy.” Henry Ford Hospital Medical Journal. 1991: 39, 138-40, and M.A. Pfeifer, et al. “A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy.” Diabetes Care. 1993: 16, 1103-15.
42 R. Tanden, et al. “Topical capsaicin in painful diabetic neuropathy: controlled study with long- term follow-up.” Diabetes Care. Jan. 1992: 15 (1): 8-14.
43 Ibid.
44 J.E. Bernstein, et al. “Topical capsaicin treatment of chronic post-herpetic neuralgia (shingles) with topical capsaicin. A preliminary study. Journal of American Academy of Dermatologists. 1987: 17, 93-96. See also Murray, The Healing Power of Herbs, 72.
45 Sid Kircheimer. The Doctor’s Book of Home Remedies. (Rodale Press, Emmaus, Pennsylvania: 1993), 228.
46 Murray, The Healing Power of Herbs, 74.
47 G.M. McCarthy and D.J. McCarty. “Effect of topical capsaicin in therapy of painful osteoarthritis of the hands.” Journal Rheumatol. 1992: 19, 604-07. See also C. L Deal, et al. “Treatment of arthritis with topical capsaicin: A double blind trial.” Clinical Therapy. 1991: 13, 383-95.
48 Murray, The Healing Power of Herbs, 74.
49 Kircheimer, 14.
50 Murray, The Healing Power of Herbs, 74.
51 Michael T. Murray, N.D. and Joseph Pizzorno, N.D. Encyclopedia of Natural Medicine. (Prima Publishing, Rocklin, California: 1991), 419.
52 J. Y. Kang, et al. “The effect of chile ingestion of gastrointestinal mucosal proliferation and azoxymethane-induced cancer in the rat.” Journal of Gastroenterology- Hepatol. Mar-Apr. 1992: 7 (2): 194-98.
53 K. G. Yeoh, et al. “Chile protects against aspirin-induced gastroduodenal mucosal injury in humans.” Dig-Dis-Sci. Mar. 1995: 40 (3): 580-83.
54 Ibid.
55 Ibid.
56 L. Limlomwongse, et al. “Effect of capsaicin on gastric acid secretion and mucosal blood flow in the rat.” Journal of Nutrition. 1979: 109, 773-
77. See also T. Kolatat and D. Chungcharcon. “The effect of capsaicin on smooth muscle and blood flow of the stomach and the intestine.” Siriraj Hospital Gazette. 1972: 24, 1405-18, O. Ketusinh, et al. “Influence of capsaicin solution on gastric acidities.” A m e r i c a n Journal of Proceedings. 1966: 17, 511-15, and Mowrey, 48.
57 Mowrey, 48 and Limlomwongse, 773-77.
58 M. Horowitz, et al. “The effect of chile on gastrointestinal transit.” Journal of Gastroenterology-Hepatol. Jan-Feb, 1992 7 (1): 52-56.:
59 Christopher Hobbs. “Cayenne, This Popular Herb is Hot.” Let’s Live. April 1994: 55.
60 V. Badmaev and M. Majeed. “Weight loss, the Ayurvedic system.” Total Health. Aug, 1995: 17 (4): 32-35.
61 Murray, The Healing Power of Herbs, 75.
62 C.N. Ellis, et al. “A double-blind evaluation of topical capsaicin in pruritic psoriasis.” Journal of the American Academy of Dermatology. 1993: 29 (3): 438-42.
63 Murray, The Healing Power of Herbs, 75.
64 S. Marabini, et al. “Beneficial effect of intranasal applications of capsaicin in patients with vasomotor rhinitis.” Eur Arch-Otorhinolaryngol. 1991: 248 (4): 191-94.
65 Ibid.
66 Mowrey, 242.
67B. Dib. “Effects of intrathecal capsaicin on autonomic and behavioral heat loss responses in the rat. Pharmacol Biochem Behav. 1987: 28, 65-70.
68 Murray, The Healing Power of Herbs, 72.
69 Christopher, 31.
70 M. Ponce, et al. “ In vitro effect against giardia of 14 plant extracts.” Rev-Invest-Clin. Sept- Oct. 1994: 46 (5): 343-47.
71 Ibid.
72 Humbart Santillo. Natural Healing with Herbs. (Hohm Press, Prescott, Arizona: 1993), 100.
73 Daniel B. Mowrey. “Capsicum ginseng and gotu kola in combination.” The Herbalist premier issue, 1975: 22-28.
74 Ibid.
75 Mowrey, The Scientific Validation of Herbal Medicine, 102.
76 J. Roquebert, et al. “Study of vasculotropic properties of Capsicum annuum.” Annales Pharmaceutiques Francaises. 1978: 36 (7-8): 361-68.
77 Rita Elkins. Depression and Natural Medicine. (Woodland Publishing, Pleasant Grove, Utah: 1995), 161.

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Date: June 23, 2005 11:20 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: CLINICAL APPLICATIONS OF CAPSICUM

CLINICAL APPLICATIONS OF CAPSICUM

Capsicum is a remarkable whole body stimulant that can boost blood flow, tone the nervous system, relieve indigestion, promote sweating, help to cauterize and heal ulcers, ease persistent pain and fight off infection. One very authoritative work on African plants suggests that Capsicum’s “regular ingestion is highly beneficial in hemorrhoids, varicose veins, anorexia, liver congestion and vascular conditions . . .the indigenous inhabitants of Africa and of the Antilles are remarkably free form all of these conditions as they use Capsicum fruit in their diet.”10 Most of the therapeutic actions of Capsicum are attributed to the alkaloid or glucoside content of the herb.11 The latest scientific studies conducted with Capsicum will be discussed in subsequent sections.

Herbal Catalyst

Because Capsicum boosts peripheral circulation and stimulates organ secretion, it expedites the therapeutic delivery and action of other herbs. In other words, the medicinal benefits of these herbs reach infected or inflamed tissue more rapidly due to enhanced blood flow.12 Consider the following statement: “Cayenne will insure the rapid and even distribution of the active principles of the rest of the herbs to critical function - al centers of the body, including those involved in cellular respiration, metabolism, data transmission, and neural-hormonal activation. Cayenne is included in several other blends for this reason. In extremely small quantities it can dramatically increase the efficiency of most other herbs.”13 Many health practitioners believe that the key to healing is CAPSICUM stimulation. Capsicum stimulates eve rything from blood flow to peristaltic action in the stomach, to intestinal transit time. The re m a rkable ability of Capsicum to stimulate organ secretion and even heart action makes it one of the strongest natural stimulants known. Se veral different kinds of herbal blends targeting various body systems will utilize Capsicum to boost the formula’s efficacy.

Cardiovascular Tonic

Capsicum is said to be unequaled for its ability to boost circulation and increase heart action. Interestingly, cultures who consume significant amounts of cayenne pepper in their diet have much lower rates of cardiovascular disease.14 Capsicum exerts a variety of desirable actions on the entire card i ovascular system. It has the extraordinary ability to enhance cardiovascular performance while actually lowering blood pressure.15 A quote taken from a card i ovascular publication re a d s , “Capsaicin has also been shown to prolong cardiac action potential in atrial muscle . . .”16 Michael T. Murray, N.D., has stated, “ Cayenne pepper [Capsicum] should be recommended as a food for its beneficial antioxidant and cardiovascular effects.”17 Herbalists have considered Capsicum as a superior “f o o d” for the heart. In fact, in cases where a heart attack is suspected administering capsicum in hot water has been thought to help lessen the severity of the attack. Capsicum can also be placed on or under the tongue in emergencies involving heart attack, stroke or hemorrhaging. 18 Note: Using Capsicum for any heart-related problem, especially a suspected heart attack should never take the place of medical attention or a physician’s care.

CAPSICUM Blood Cholesterol Reducer

Various studies have conclusively demonstrated that Capsicum reduces the risk of developing atherosclerosis (hardening of the a rteries) by reducing blood cholesterol and triglyceride levels .19 Additional clinical studies conducted in India found that when cayenne was ingested along with dietary cholesterol, the typical rise in liver and blood serum cholesterol levels was significantly inhibited. In addition, bile acids and free cholesterol were subsequently eliminated from the body through the stool.20 Interestingly, these tests revealed that using Capsicum was actually more effective in reducing cholesterol that capsaicin alone.2 1 Daniel Mowrey, Ph.D., emphatically points out that this is just one of many examples of the superiority of whole botanicals as opposed to their isolated components.22 Note: Using Capsicum in combination with Hawthorn is a particularly good cardiovascular tonic.

Blood Pressure Equalizer

While an added bonus of Capsicum’s capability to lower blood serum cholesterol is a decrease in blood pressure, additional evidence strongly suggests that the herb initiates other mechanisms that fight hypertension .23 “Cayenne, according to another study, also reduces the blood pressure in an even more direct manner: a number of years ago, a team of researchers discove red that capsaicin acts in a reflexive manner to reduce systemic blood pressure, a kind of coronary chemoreflex.”24 Adding Garlic to Capsicum creates an even better therapeutic blend for treating hypertension.

Blood Detoxification CAPSICUM

“Cayenne is a kind of catalyst in the blood purification process . . . it acts as a diaphoretic, stimulating the excretion of wastes in the swe a t . ”25 Because Capsicum stimulates organ secretion and boosts peripheral blood flow, it would only stand to reason that it would also facilitate the faster removal of toxins from the bloodstream and lymphatic system. You may have already noticed that Capsicum is frequently added to blood-purifying herbal combinations. Circulatory Booster Researchers have found that the simulating action of Capsicum on surface capillaries can help to pre vent cold hands and feet.2 6 For this reason, it may be helpful for Reynaud’s Syndrome. Old remedies using Capsicum have even recommended placing it in socks to warm the feet and to help prevent frostbite. An old folk cure for a chilled body was a steaming hot cup of Capsicum tea. Free Radical Scavenger The rich flavonoid content of Capsicum gives it significant antioxidant capabilities. A recent study conducted in 1995 showed that Capsicum has a higher ascorbic acid content than chiles from the jalapeno or serrano varieties .27 Vitamin C and bioflavonoids can scavenge for dangerous free radicals which cause tissue damage and can predispose organs to degenerative diseases. Free radicals are found everywhere and are created as by-products of metabolic p rocesses including the act of breathing itself. Pollutants can expose the body to free radicals. An interesting study done in Mexico City and published in 1993 found that Capsicum extract was able to modulate the mutagenic activity of urban air samples.28 In other words, these potentially dangerous nitro - a romatic compounds found in polluted air were kept from mutating by red chile extract.29 Chemical breakdowns of Capsicum have also found that CAPSICUM the pepper is high in Provitamin A, which significantly contributes to its healing ability and immune fortification.30 Anti-Carcinogenic Compound Anti-cancer research recently tested Capsicum on laboratory rats and found that it does indeed demonstrate anti-cancer properties by inhibiting certain enzymes which can initiate the mutation of cells.31 What this implies is that taking Capsicum can afford the body some protection against the cellular mutation which occurs in malignant growths. Capsicum actually inhibited the formation of dangerous metabolites under laboratory conditions where they should have normally been activa t e d .3 2 This study implies that Capsicum may have many more sophisticated bio-chemical actions than previously thought.

An Impressive Pain Killer

Capsaicin has recently emerged as a remarkably effective pain reliever and has become the subject of recent clinical research . Applying capsaicin in cream or ointment form to painful joints, scar tissue or other painful conditions involving peripheral nerves confuses pain transmitters. In other worlds, capsaicin temporarily disrupts sensory nerve cell biochemistry there by impeding the relay of pain sensations from the skin surface. It does this by inhibiting a neurotransmitter called substance P. This specific compound is thought to be the main mediator of pain impulses from peripheral nerve endings.33 Substance P has also demonstrated its ability to inhibit inflammatory pain generated in arthritic joints in much the same way.34 Today, several over-the-counter topical preparations utilize capsaicin for the pain of arthritic joints. The ability of Capsicum to control severe and unresponsive pain is significant, to say the least. Modern clinical utilization of topical capsaicin may offer signifi-cant relief for a number of painful conditions including: diabetic neuropathy, cluster headaches, post-amputation pain, post-mastectomy pain, shingles and painful scar tissue.35

POST-SURGICAL PAIN

In the early spring of 1996, prime time national news show s reported that scientists had found that individuals who had suffered from chronic pain in post-surgical scars (heart bypass, arterial grafts, etc.) were successfully treated with topical preparations containing capsaicin. While this may have been news to many of us, clinical studies had been already published for several years that capsaicin held profound value for various kinds of pain which did not respond to established medical treatments. Typically surgical scars and regions around them can produce persistent pain or can be very sensitive to the touch even when completely healed. This type of pain phenomenon seems to respond well to capsaicin ointments and creams.

POST-MASTECTOMY PAIN

When capsaicin preparations were applied following mastectomy or breast reconstruction, pain was significantly relieved. Se veral double blind studies found that using capsaicin creams four times daily for 4 to 6 weeks resulted in much less frequent occurrence of sharp, jabbing pain.3 6 All thirteen patients studied had a 50 percent or greater improve m e n t .3 7 Various unpleasant sensations other than pain also improved with topical applications of capsaicin creams.38

MOUTH SORES FROM RADIATION OR CHEMOTHERAPY

A fascinating study conducted at the Yale Pain Management Center discove red that capsaicin could ve ry significantly lessen pain caused by mouth sores which frequently develop after chemotherapy or radiation.39 Apparently delivering the capsaicin in the form of soft candy (taffy) enabled the substance to be retained in the mouth long enough to desensitize the nerve endings causing the pain. Each one of the eleven case studies re p o rted that their pain had decreased and in two patients, it stopped entirely.40

DIABETIC NEUROPATHY

Diabetic neuropathy is a painful nerve condition which can develop in cases of prolonged diabetes. Several double-blind studies have supported the considerable value of capsaicin creams for relieving the pain associated with this disorder.41 The results of a controlled study using Capsicum for seve re cases of diabetic neuropathy which did not respond to conventional therapy were published in 1992. A cream containing Capsicum was applied to painful areas four time a day and pain was carefully e valuated for 8 weeks at two-week intervals. The results we re impressive, to say the least. In the 22 patients who used the Capsicum the following results we re re c o rded: “Capsaicin tre a tment was more beneficial than vehicle treatment in the overall clinical improvement of pain status, as measured by physician’s global evaluation and by a categorical pain severity scale . . . In a follow-up study, approximately 50 percent of the subjects reported improved pain control or were cured . . .”42 No t e : While there was a burning sensation when the Capsicum c ream was first applied, some subjects found that its magnitude and duration lessened with continued application.43

SHINGLES

The FDA has approved capsaicin-based ointments for the treatment of pain that results from diseases like shingles. Again, numerous studies have documented the value of capsaicin for decreasing the miserable nerve-related pain associated with shingles. The general consensus derived from these tests were that approximately 50 p e rcent of people suffering from shingles responded well to capsaicin creams, some even after 10 to 12 months.44

Note: If blisters accompany a shingles outbreak, it is better to wait until they have healed before using any capsaicin-based ointments or creams.

RELIEF FOR BURNING FEET

Frequently an uncomfortable “burning” sensation in the feet will occur in many people, particularly in diabetics. As ironic as it may seem, using capsaicin creams may actually alleviate this burning. “In various studies, diabetics who treated their burning feet with capsaicin got greater improvement and we re able to walk more easily than those not using the cream.”45 In addition, using topical applications of capsaicin as opposed to strong, oral drugs is much more preferable.

ARTHRITIS PAIN

Clinical tests have confirmed that topical capsaicin ointments substantially alleviate the miserable pain that characterizes osteoand rheumatoid arthritis.46 These studies revealed that using 0.075 capsaicin cream reduced tenderness and pain.47 Dr. Michael T. Murray writes: “ . . . seventy patients with osteoarthritis and thirty - one with rheumatoid arthritis received capsaicin or placebo for 4 weeks. The patients were instructed to apply 0.025 percent capsaicin cream or its placebo to painful knees four times daily. Significantly more relief of pain was reported by the capsaicin-treated patients than by the placebo patients throughout the study . . .”48 Anyone suffering from osteo or rheumatoid arthritis should evaluate the effectiveness of capsaicin ointments for joint pain. Ester Lipstein-Kresch, M.D., has studied the effectiveness of capsaicin creams for arthritis and has stated: “You need to apply it three or four times a day on the affected area for at least two weeks before you’ll see any improvement. An initial burning sensation at the site is not unusual for the first few days, but this goes away with continued application.”49 Note: Capsaicin is also useful for tennis elbow due to its ability to block the transmission of pain.

MIGRAINE HEADACHES (CLUSTER TYPE)

Topical applications of capsaicin ointments intranasally may also help to relieve the pain of a specific kind of migraine headache called cluster headaches. Cluster headaches are characterized by s e ve re pain which typically radiates around one eye. The term “cluster” refers to the fact that these headaches tend to occur in clusters of one to three per day and can recur at intervals. Headache pain and severity we re reducing in groups using intranasal capsaicin.5 0 This type of capsaicin treatment should be done under a physician’s care. There is some speculation that capsaicin may be more effective in pre venting migraines before they develop into a full blown attack.51

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Date: June 21, 2005 05:10 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Take Your Vitamins: Reviewing Scientific Approaches to Selecting Daily Multiple Supplement

Take Your Vitamins: Reviewing Scientific Approaches to Selecting Daily Multiple Supplements

By Adina Licht, MS

Adina Licht, M.S. is a Nutritional Scientist and Science Writer who works as a Marketing Specialist for Source Naturals. She has a B.A. in Environmental Science from UC Berkeley, an M.S. in Nutrition and Food Science from San Jose State University, and training in Technical Communication from Cal State Hayward. Her work has appeared in publications such as Advances in Packaging and Development, Health Supplement Retailer and Delicious Living.

Americans Need More Nutrients

The U. S. population is drastically malnourished. According to the latest A. C. Nielsen survey, only 12% of Americans claim to eat the 5 recommended servings of fruits and vegetables each day (Warner, 2004). And approximately 1/3 of the calories that people do consume are from nutrient-poor foods such as alcohol and soda (Yang, 2004). This combination has led to a population that consumes too few nutrients, which according to an article in the Journal of the American Medical Association (Fletcher, 2002) puts people at risk for long-term health concerns. With Americans eating fewer healthy foods, taking a daily multiple is one way for people to increase their intake of nutrients. But the search for what defines a good multiple can be confusing, even to health care professionals.

The Confusing U.S. Government Standards

Scientists first recognized the need for vitamins in the early 1900s (Levenstein, 1993). But setting U. S. government standards for vitamins and minerals didn't start until healthy soldiers were needed to fight World War II. And when a committee of scientists was asked to determine the levels of nutrients needed to maintain good health they could only agree on "recommended allowances" to prevent deficiency with a wide margin of safety. In 1941, these allowances became the first Recommended Dietary Allowances (RDAs) for the nation (Levenstein, 1993). In 1997, the Food and Drug Administration (FDA) used latest RDAs to set the new Dietary Reference Intake (DRI) standards, which included Adequate Intakes (AIs) for when there was insufficient evidence to determine an RDA, and Upper Intake Levels (ULs) as the safe daily upper limit. To simplify the information, food labels express nutrient information as a percentage of the Daily Value (DV), which includes RDA values for a healthy adult who consumes 2000 calories per day (Whitney, 2002). However, these values do not include AIs or ULs and many individuals need different levels of nutrients than these.

Confusing Standards equals Confusing Recommendations

The RDAs and subsequent DRIs are the basis of the nutrient standards for at least 40 different nations and many professional health organizations. Currently, the American Dietetic Association (ADA) recommends that people who cannot reach the DRIs through diet take a multiple with nutrient levels that do not exceed the RDAs (JADA, 2001). And in 2002, the American Medical Association (AMA) published a paper that included a recommendation for all adults to take RDA levels of vitamin supplements in their Journal of the American Medical Association (Fletcher, 2002). Despite the benefits of having guidelines, most people only hear about the RDAs and DVs, which may be too low for preventing deficiencies while the ULs and AIs, which can be much more beneficial are rarely discussed. For example, the Daily Value of Vitamin E to prevent deficiency is 30 IU while the daily Upper Intake Limit is 1,467 IU. But, according to the ADA, as many as 75% of cardiologists recommend vitamin E to their patients to promote heart health, usually at a dosage of 400 IU (ADA, 2001; Meydani, 2004; & Whitney, 1998). And the Daily Value for Vitamin C is 60 mg while the daily Upper Intake Limit is 2000 mg, but in clinical studies it took 500 mg per day to help maintain healthy blood pressure (Whitney, 1998, & Hendler, 2001).

Alternative Recommendations

Lyle MacWilliam is a biochemist and former health advisor to the Canadian Ministry of Health, who decided to research, analyze and publish the Comparative Guide to Nutritional Supplements. In this book, the individually published recommendations from seven nutrition experts (Phyllis Balch, CNC, Dr. Michael Colgan, Ph.D., Dr. Earl Mindell, Ph.D., Dr. Michael Murray, N.D., Dr. Richard Passwater, Ph.D., Dr. Ray Strand, M.D., and Dr. Julian Whitaker, M.D.) were combined to create an ultimate blended standard of recommended median intakes for 39 nutrients to promote health. Those nutrients include vitamins, minerals, phytonutrients, and other supplements, that span 14 different health categories and are much closer to the Upper Intake Limit government standards. The guide also includes information about recommended forms, safety, purity and quality (MacWilliam, 2003). One of the most profound differences between MacWilliam?s compiled recommendations and the DRIs is the difference in the number of supplements: 39 vs. 26 respectively. The Comparative Guide standard includes additional nutrients, including many more antioxidants, based on decades of clinical research about their benefits. For example, the fat-soluble antioxidant Coenzyme Q10 that your body manufactures less of as you age is included. So is the fat and water-soluble antioxidant alpha lipoic acid that helps recycle other antioxidants such as vitamins C and E (Hendler, 2001).

Top Ranked Multiples for Optimal Health

In the latter half of MacWilliam's book he uses this ultimate blended standard to rank and compare 500 manufactured multiples. Of the five top-ranked multiples, only the Source Naturals multiples, Life Force and Élan Vitàl, are widely available at natural product stores and health outlets. And the new and improved Life Force formulation now rates higher than any of the products evaluated in the current edition of this guide (MacWilliam, 2004; & Mac-William, 2003). The ingredients that can be found in today's multiple supplements can vary greatly. But multiple choices don't have to lead to confusion. Health professionals, such as Lyle MacWilliam, understand the importance of remaining curious, evaluating the available research, and conferring with other scientists to determine the nutrients that support optimal health.

References

American Dietetic Association. 2001. Vitamin E: Disease Prevention for your Good Health. American Dietetic Association Website. Available at: Public/Other/index_nfs1001.cfm Fletcher, R. H., & Fairfield, K. M. 2002. Vitamins for Chronic Disease Prevention in Adults. JAMA. (23)287:3116-3129. Hendler, S. S., et al. 2001. PDR for Nutritional Supplements. Thomson Healthcare: Montvale. Pages 11-12, 17-21, 60-62, 103, 416-421, 486-498. JADA (Journal of the American Dietetic Association) 2001. Vitamin and mineral supplementation. J AM Diet Assoc.101: 115 Available at: Public/NutritionInformation/92_8343.cfm Levenstein, H. 1993. Paradox of Plenty: A Social History of Eating in Modern America. Oxford University Press: New York. Pages 13-15, 64-67. MacWilliam, L, et al. 2003. Comparative Guide to Nutritional Supplements. Northern Dimensions Publishing: Vernon. Pages 62-70. MacWilliam, L. 2004. Comparative Guide Individual Assessment of New Life Force Formulation. Warner, J. 2004. Few Follow '5 a Day' Fruit and Vegetable Rule. WebMD website. Available at: ent/Article/93/102158.htm Whitney, N. W., & Rolfes, S. R. (1998). Understanding Normal and Clinical Nutrition, 5th ed. Page 358. Whitney, E. N., & Rolfes, S. R. 2002. Understanding Nutrition. 9th ed. Wadsworth Thomson Learning: Belmont. Pages A, B, Y, 13-20, 55-56, 307, 331, 335-341, 401. Yang, S. 2004. Nearly one-third of the calories in the US diet come from junk food, researcher finds.

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Date: June 21, 2005 05:05 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: 7-Keto - The Key to Healthy Aging

7-Keto " The Key to Healthy Aging

The global population is aging at an alarming rate and causing an explosion in health care costs, insurance premiums, cosmetic surgery and more. In the U.S. alone, more than one million baby boomers are expected to live to 100 years of age or older. This increased life expectancy presents a whole new set of health concerns that the medical community has not had time to address, since there is a greater need to care for age-related health problems in this ever-growing elderly population.1

Aging and the Decline in Vital Nutrients

We all grow old at the same rate but people age at different rates. Aging is a process of gradual changes that occur to varying degrees in each of us. Interestingly, the aging process is composed of different components and interactions, some of which can be impacted. One such component is the declining level of essential biological compounds, which causes our bodily functions to slow and become dysfunctional. Our organs don?t work efficiently, our immune system becomes lazy, we lack energy, our metabolism drops and we gain weight easily.1 7-oxo DHEA (7-Keto™) is a naturally occurring compound that declines with age.2 Replacing this key metabolite helps promote a healthy immune system and maintains resting metabolic rate at levels that accelerate weight loss during standard weight reduction programs.

Aging and a Healthy Immune System

Numerous changes occur in the immune system with advancing age, probably contributing to decreased immune responsiveness. Although all segments of the immune system are affected, investigators have most consistently identified declines in cellular or T-cell mediated immune function in the elderly. The decline in T-cell immune function is generally associated with an increased susceptibility to foreign organisms. For example, individuals with age-related declines in cellular immunity have an impaired response to vaccinations, making them more susceptible to health imbalances even though they have had their shots. In a clinical study presented at the Federation of American Societies for Experimental Biology meeting in April 2004, the effect of 7-Keto on elderly immune function was evaluated. Healthy elderly adults were given 7-Keto orally twice daily over a period of one month. The study revealed that 7-Keto augmented several key T-cell mediated immune function parameters compared to placebo administration.4

Age-Related Weight Gain

Age-related weight gain and obesity are approaching epidemic proportions in our country.5 Weight gain is a disorder of energy balance involving energy intake and/or expenditure. Low energy expenditure, a drop in resting metabolic rate (RMR), is a challenge during most weight loss attempts due to age, calorie restriction, lack of physical activity or a combination of factors. RMR represents 60% of total daily energy expenditure. Maintaining a higher RMR as we age and during weight reduction programs helps us achieve and maintain a normal weight. Furthermore, compounds with the thermogenic potential to achieve even minimal increases in daily energy expenditure of 2-3% may have clinical relevance in preventing the decline in RMR with calorie restricted diets or weight loss, and in decreasing the risk of regaining weight. 7-Keto, a non-stimulant thermogenic compound, has been shown to significantly increase energy expenditure in humans.6 A recently completed clinical study, also presented at the Federation of American Societies for Experimental Biology 2004 meeting, revealed that administration of 7-Keto to overweight adults in conjunction with a calorie restricted diet effectively reversed the decline in RMR normally associated with dieting. Obese participants following a calorie-restricted diet demonstrated a 5.4% increase in daily RMR with 7-Keto.7 The magnitude of the increase in RMR by 7-Keto is clinically relevant, and represents a promising agent for enhancing thermogenesis and weight loss in obese individuals on calorie-restricted diets. Additionally, 7-Keto has been shown in two confirmatory published clinical studies to result in three times more weight loss compared to diet and exercise alone. It has a favorable side effect profile and is easy and convenient to take.8,9 Our life expectancies will likely be longer than those of our parents, and our quality of life during those years will depend on how well we take care of our bodies now. Undoubtedly, the science of aging will give rise to new and exciting technologies to help us age more gracefully and healthfully. Maintenance of healthy immune function is keenly needed for improved quality of life in the elderly. Dietary manipulation and supplementation has been identified as a method of immune system renewal, and supplements such as 7-Keto may play an important future role as immune system modulators. Moreover, the addition of 7-Keto to any weight loss program will offer vital support of energy expenditure and help with the attainment of a manageable and healthy weight into our older years.

References

1. 1995 White House Conference on Aging, ?Executive Summary: The Road to an Aging Policy for the 21st Century," February 1996: 17-18. 2. Marenich LP. Secretion of Testosterone, Epitestosterone, Androstenedione, and 7-Keto-Dehydroepiandrosterone in Healthy Men of Different Ages. Prob Endokrinol. 1979; 25(4): 28-31. 3. Ginaldi L, De Martinis M, D?Ostilio A, Marini L, Loreto MF, Quaglino D. Immunological Changes in the Elderly. Aging 1999; 11(5): 281-286. 4. Zenk JL, Kuskowski MA. The Use of 3-acetyl-7-oxo-dehydroepiandrosterone for Augmenting Immune Response in the Elderly, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 5. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and Trends in Obesity Among US Adults. 1999-2000. JAMA 2002;288:1723-1727. 6. Astrup A. Thermogenic Drugs as a Strategy for Treatment of Obesity. Endocrine 2000;13(2):207-212. 7. Zenk JL, Leikam SA, Kassen LJ, Kuskowski MA. A Prospective, Randomized, Double Blind Study to Evaluate the Effect of HUM5007 and 7-oxo DHEA on Resting Metabolic Rate in Overweight Adult Men and Women on a Calorie Restricted Diet, Abstract Presented at the meeting of the FASEB, April 17, 2004, Manuscript submitted for publication. 8. Kalman DS, Colker CM, Swain MA, Torina GC, Shi Q. A Randomized, Double-Blind, Placebo Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Healthy Overweight Adults. Current Therapeutic Research 2000;61: 435-442. 9. Zenk JL, Helmer TR, Kassen LJ, Kuslowski MA. The Effect of 7-Keto Naturalean on Weight Loss: A Randomized, Double-Blind, Placebo-Controlled Trial. Current Therapeutic Research 2002; 63:263-272.

John L. Zenk, M.D., is Chief Medical and Scientific Officer for Humanetics Corporation and President and Medical Director of Minnesota Applied Research Center, both located in Eden Prairie, MN. He has spoken nationally and internationally on the subjects of integrating conventional and complementary medicine, anti-aging technologies, evaluating the effectiveness of alternative medicine, and dietary supplement research and development. He is author of the book Living Longer in the Boomer Age, and co-author of the book Age Wise and is a frequent contributor to national media. He has served as Principal Investigator for 15 controlled clinical studies, three of which were recently published in national peer-reviewed journals, and has presented abstracts at the 11th World Congress for Food Science and Technology and the Federation of American Societies for Experimental Biology.

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Vitanet ®

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Date: June 18, 2005 09:07 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Anti-Aging Nutrients

Anti-Aging Nutrients by Edward C. Wallace, DC, ND Energy Times, February 3, 2000

What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful, easy feeling.

How Do We Age?

Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

Programmed Cell Theory

In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

Free Radical/Oxidative Stress Theory

The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain. On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents.

Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution. Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

DNA Repair Theory

Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

What Can We Do?

The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

Antioxidant Protection

Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.) Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725). Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

Nutrition Deficiencies

A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

Longevity Diets

A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460).

Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers (Epidemiology 3[5], 1992: 389-391).

Staying Alive

Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

Longevity and Exercise

Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184). In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

The Treadmill of Life

The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying (JAMA 273 [14], April 12, 1995: 1093-1098).

Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

Longevity Supplementation

Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging. Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

Toning Down Enzymes

Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls. In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

Vitamins E & C

A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

Chronological Age Vs.Biological Age

Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems.

In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

Similar Relationship

A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less.

And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

Carotenoids

When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119[1], Jan. 1989: 112-115).

Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

Flavonoids

Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs. For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

Amino Acid Health

Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68). As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

Attitude & Behavior

Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit. In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

Longevity at Last

While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of longer life. And by staying healthier, your old age will be more enjoyable, too.

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Vitanet ®

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Date: June 13, 2005 10:11 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Ocean Treasures - For centuries, people have flocked to the sea....

Ocean Treasures by Chrystle Fiedler Energy Times, January 3, 2004

For centuries, people have flocked to the sea to take advantage of its healing and restorative powers.

"The ocean is alive with energy and abundant sea life," says Susie Galvez, owner of Face Works Day Spa in Richmond, Virginia and author of Hello Beautiful (MQ Publications). "It's an abundant source. Sea products are rich in minerals like magnesium, potassium, iron and zinc, all of which are known for their deeply cleansing and antibiotic properties. When we think of the sea, we think of health, invigoration, the feeling of being alive and yet peacefully calm."

"To the ancient Greeks, the image of Aphrodite rising out of the sea was beautiful because of the nutrients that the sea plants had given her," says Linda Page, ND, in Healthy Healing (Healthy Healing Publications). Today, sea plants still provide beauty benefits. "They have a complete spectrum of chelated minerals, which makes them easier to absorb, that add lustre and shine to your hair and eyes and improve skin texture and tone."

Thalassotherapy (seawater treatment) includes using salts, mud, foliage, sand and water from the sea to stimulate, hydrate and nourish the skin, making it smoother, firmer and more resilient.

"Using sea products in treatments is both restorative and detoxifying," says Galvez. "Now with modern technology, you don't have to live anywhere near the sea to take advantage of the wonderful health and wellness benefits. Your sea retreat source can be as close as your health food store."

Seaweed's Beauty Benefits

"Pollution, stress, fatigue and bad eating habits all affect the body," says Anne Mok, LaC, a certified Chinese herbalist and co-owner of Cornerstone Healing in Brooklyn, New York. This leads to vitamin and mineral deficiencies that can result in broken capillaries, loss of firmness, skin lesions, dry scaliness and more.

The good news, Mok says, is since seaweed is packed with easy-to-absorb proteins, vitamins, minerals and lipids, it can protect against environmental pollution and ward off aging by nourishing and moisturizing the skin. "The seawater in seaweed is similar to human plasma, so it's an ideal way to get the nutritive benefits from the sea, vitamins A, C and E, and the minerals zinc, selenium and magnesium we need through the process of osmosis. Seaweed cleanses, tones and soothes the skin and regenerates body tissues, offering a new vitality and helping to maintain a youthful appearance. It also improves circulation, which has a positive effect on local fatty overloads and helps maintain the tone of the tissue." No wonder seaweed is used to firm the skin and reduce the appearance of cellulite!

Seaweed captures all the richness from the sea. "There is no genetic manipulation, fertilizer or pesticides, just the sea, light and the tides," says Mok. "[S]eaweed is ten times richer in trace elements than land plants."

Beauty aids from the sea include:

* Kelp (laminaria), a large leafy brown algae, grows along cold climate coastlines and can bring a healthy glow to skin. "Kelp powder has exfoliating properties that make it a great addition to a facial mask," Galvez adds. "It increases blood circulation and stimulates lymph production to eliminate toxins. It's also a mineral-rich body scrub for removing surface impurities."

* Crushed algae is often used in seaweed masks.

* Carrageenan, a gel extracted from Irish sea moss, is commonly used as a cosmetic thickening agent. "It's a great moisturizer that holds nutrients and water in," says Mok.

* Bladderwrack (fucus), a brown seaweed, is often used in cellulite-reducing creams to eliminate excess fluid from the skin.

A Seaweed Beauty Routine

Incorporating the benefits of seaweed into your beauty routine is easy. You can "purchase dehydrated seaweed at a natural food store to make your bath a mini-ocean," says Janice Cox, author of Natural Beauty at Home (Henry Holt & Co). "Fill the tub to the point that you're covered when you lie down," says Dr. Page. "The idea is to make your body sweat, to open your pores, release toxins and take in the sea nutrient benefits by osmosis. Boost the effect with a few drops of aromatherapy bath oils like rosemary and lavender. It'll help hold the heat in and improve your cleansing program." Rinse off and "you'll feel your skin tighten, due to the high iodine content of the seaweed," says Cox. "Your skin should also feel softer and firmer."

Seaweed and algae body wraps are ideal ways to beautify the skin, rid your body of toxins and boost well-being and health. "It starts a program of detoxification very rapidly," says Dr. Page, who has also written Detoxification: All You Need to Know (Healthy Healing Publications). "It's amazing how it encourages weight loss and cellulite reduction." "Seaweed wraps are the most effective cellulite treatments," says Mok. "Seaweed and seaweed mud, especially, stimulate the cells to improve cellular activity and increase the efficiency of lymphatic fluid, which helps break down toxic deposits that can result in cellulite.

"It's excellent conditioning for the skin and leaves it soft and glowing," says Claudia Spagnolo, spa director for the DeFranco Spagnolo Salon and Day Spa in Great Neck, New York.

Revitalize With Sea Salts

Sea salts contain minerals-such as calcium, potassium, magnesium, sodium, iron, sulphur, phosphorus and chlorine-that have a delightfully rejuvenating and revitalizing effect on skin.

"Sea salts enhance the youthful healthy glow of the skin," says Spagnolo. "It creates a deep pore cleansing from shoulder to toe, removing rough, dry skin, helping to purify and slough off dead skin cells. It's great for an all-over exfoliation, and leaves the skin smooth and refreshed."

"Sea salt has wonderful drawing properties, promoting the removal of toxins from the skin," says Galvez, author of Ooh La La Effortless Beauty (MQ Publications). "It's high in mineral content and nourishes the body."

Sea salt also "guards against moisture loss, so it's ideal for dry skin and helps prevent aging," says Mok. In addition, it can be used to treat acne, eczema and psoriasis. Often done before a massage in spas, a "salt glow," which uses a vigorous scrub of coarse sea salts mixed with essential oils, rejuvenates and revitalizes the skin. Sea salt is also readily available at health food stores so you can do the same at home.

Mineral-rich Dead Sea salts pack a salinity of 32%. "When bathing with Dead Sea salt you don't even need to use soap because the minerals remove redundant fat and dirt," says Mok. Dead Sea minerals are often used in shampoos, conditioners and shower gels. "Galvez adds, "Dead Sea mud mineral and vitamin content is very close to that of humans, and therefore treatments using the mud penetrate deeply."

Ah! Home Spa

It's easy to turn your bathroom into an oasis of calm and create a private spa to call your own.

For a sea cure bath, mix together half a pound of sea salt and a pound of baking soda, add to a warm water bath and soak until the water has cooled, says Mok. "It's excellent for soothing itchy and dry skin and helps detoxify by pulling out toxic waste from the pores." Aromatherapy oils, like lavender, make your soak in the tub even more relaxing and luxurious. "It's a great way to de-stress after a long day at work."

A seaweed wrap can release water retention and leave legs looking their sleekest, notes Mok. "Just soak legs in a bath of warm water and Epsom salts for 5 minutes, then pat dry. Apply a seaweed mask and wrap legs with plastic wrap and a warm towel. Relax for 15 minutes. Remove towel and plastic wrap and rinse."

You can also try a sea salt rub by mixing two cups of kosher salt with one cup of olive oil until it forms a thick paste. (Be careful: the oil is slippery.) "While in the tub or shower, massage it into your skin using long strokes toward the heart, starting with your feet," says Galvez. Rinse off with warm water, use a soft washcloth to remove any residue, pat dry and apply moisturizer. "Your skin will be silky smooth and wonderfully hydrated." To create a spa environment at home, details make all the difference. "Think of your favorite beach get-a-way and go with an ocean theme," says Cox. "Include something for each of the senses." For example, put on a CD that has nature sounds. To capture the color of the water, use sea-colored towels. For scent, light candles that produce the scents of flowering plants (such as plumeria or citrus). Add "ocean" fragrance beads. When taking a bath, "use shells to scoop out sea salts or dehydrated sea weed and put them around the tub as decoration," says Cox. Smooth on a moisturizer with a sea-scented lotion when you finish your spa treatment.

When you make an at-home sea spa experience a regular part of your routine, you reap a bounty of beauty and health benefits. "In just 20 minutes you can have a mini-vacation," says Galvez. "It's cleansing and relaxing."

Then you will be ready to dive back into reality with renewed zest.

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Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=322)

Date: June 12, 2005 01:55 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Home Spa Secrets

Home Spa Secrets by Carol Perkins Energy Times, July 12, 2003

The luxurious feeling that comes over you in a pampering spa atmosphere can be yours at home without having to venture out to an exclusive resort. Lock the door, put on relaxing music and fill the air with luscious scents. Rejuvenation, regeneration and health-promoting sensations await!

If you decide to indulge in a home spa, cleansing, detoxifying and kicking back in an unstressed atmosphere, you can prepare yourself for your spa activities by sipping what Ann Louise Gittleman, PhD, calls a "Living Beauty Elixir," a blend of eight ounces of unsweetened cranberry juice with two teaspoons of a green superfood mixture "rich in purifying chlorophyll and detoxifying antioxidants and nutrients."

This drink, as Dr. Gittleman points out in The Living Beauty Detox Program (Harper), "helps the liver... open up the detoxification pathways....It's a marvelous cleanser for the lymphatic system...removing wastes from the cells via the connective tissue." The green food mixture that Dr. Gittleman recommends includes nutritious items available from your local natural food store that contain chlorophyll-rich foods such as chlorella and spirulina.

Dim the Lights, Light the Candles

Setting a relaxed, soothing atmosphere is a vital part of the total home spa experience. For the right kind of luxurious ambiance, Aloha Bay's Bright Bouquets candle offers three fragrances in one vase for a selection of tantalizing aromas. Improving the experience, these 100% pure natural wax blends offer about 100 hours of clean burning for an seemingly endless at-home spa getaway (1-800-994-3267, www.alohabay.com). Once you have your candles lit and your bathtub running, you can boost your bathing experience with botanicals from the sea.

According to Linda Page, ND, PhD, author of Healthy Healing (Healthy Healing Publications), "Beauty treatments from the sea are one of nature's most ancient beauty therapies. In Greece, Aphrodite's beautiful skin, hair and sparkling eyes were attributed to plants from the sea. The collagen in sea plants is great for relieving wrinkles and brown spots."

Dr. Page suggests making a seaweed mask by mixing 1/2 tablespoon of ground kelp flakes with a tablespoon of aloe vera gel, leaving this mixture on your face and neck for 10 minutes. "This can help heal scars from facial surgery and is also good for the thyroid. Over 15 million people may have a low thyroid."

Another great mask can be made from derma e's deliciously soothing Papaya and Soy Milk Clarifying Facial Mask. Designed especially for sensitive skin, this soothing mask helps exfoliate dead skin cells and clean pores of pollution and debris while conditioning and nourishing for silky skin (1-800-521-3342, www.dermae.net).

Seaweed Bath

Dr. Page also recommends filling your tub with seaweed, which will turn the water a refreshing green. She says that "packaged seaweed soaks can be put right into the tub, or they can be used in a muslin bag which is placed in the water. That makes for an easier clean-up.

"Fill the tub about two-thirds full with very hot water, put in the seaweed (dried or fresh), which will make the water look like a green sea garden. Keep the water filling the tub slowly to maintain a warm temperature and stay in it for about 20 to 25 minutes. It's great for detoxification, and you can enhance the experience with a few drops of lavender and chamomile."

The gel from the seaweed will coat your skin. When the gel comes off, the bath is over and you have received the full regenerative effects of the plants. When you use this bath as part of your home spa, Dr. Page says that about 45 minutes should be longest you stay in the tub, and if you're using stimulating botanicals like cayenne or ginger, take these after the bath, not before.

After you climb out of the bath, you can give yourself a complete manicure with Baywood's all-in-one hand and nail formula made of dead sea salts, herbs and essential oils. Appropriately named, Baywood's Complete Manicure cream exfoliates and replenishes your skin with nutrients making it feel soft and silky in minutes (1-800-481-7169, www.bywd.com). Then you can apply soothing, nourishing creams to your hands with DreamTime's Hand Cozys that soothe away aches and arthritic pain, and comfort overworked hands. Designed like large oven mitts, these fashionable gloves make a perfect at-home spa treatment when used with your favorite nourishing hand lotion. The warmth of the Hand Cozys help your skin absorb lotion more readily, making your hands soft and supple (1-877-464-6702, www.Dreamtimeinc.com).

Relax to the Max

You should further enhance your spa experience with soothers like Intensive Care Capsules from Annemarie Borlind. These Intensive Care Caps are a weekly replenishment treatment designed to repair damage from sun and wind, offering significant relief from dry skin. Each capsule contains a high concentration of borage seed oil and natural ceramide to deliver new moisture, vitality and elasticity, while being gentle enough for even the most sensitive skin (1-800-447-7024: request a free beauty newsletter; www.borlind.com).

And you can reward your skin with Zia's Body Butter. This dream cream combines mango and shea butters to actually heal the skin while moisturizing it (1-800-334-7546, www.zianatural.com).

Feet Time

An indulgent highlight of your home spa experience can be treating your feet to relaxing rubs and aromatherapy.

As Frazesca Watson points out in Aromatherapy Blends & Therapies (Thorsons), a drop or two of lavender and chamomile added "to a bowl of warm water and soak(ing) the feet for approximately 10 minutes... (can) help colds, varicose veins, athlete's foot, sore and painful feet, and swollen ankles."

The most important element of your foot soak, like everything in your home spa treatment, is the calming and relaxing effect. Healing and soothing, these treatments can keep you on an even temperament in a hectic world.

So shut the light, close the shades, light the candles and get ready to spa.

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Vitanet ®

Where to find Super CranActin on VitaNet?

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=302)

Date: June 10, 2005 09:59 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Nutrients for Longevity

Nutrients for Longevity by Edward C. Wallace, ND, DC Energy Times, September 1, 1999

What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful easy feeling.

How Do We Age

Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

Programmed Cell Theory

In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

Free Radical/Oxidative Stress Theory

The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain.

On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents. Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution.

Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

DNA Repair Theory

Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

What Can We Do

The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

Antioxidant Protection

Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.)

Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725).

Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

Nutrition Deficiencies

A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

Longevity Diets

A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460)

Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers. (Epidemiology 3[5], 1992: 389-391).

Staying Alive

Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects. (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

Longevity and Exercise:

Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184).

In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

The Treadmill of Life

The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying. (JAMA 273 [14], April 12, 1995: 1093-1098).

Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

Longevity Supplementation

Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging.

Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

Toning Down Enzymes

Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls.

In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

Vitamins E & C

A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

Chronological Age Vs. Biological Age

Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems. In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

Similar Relationship

A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less. And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

Carotenoids

When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119(1), Jan. 1989: 112-115).

Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

Flavonoids

Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs.

For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

Amino Acid Health

Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68).

As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

Attitude & Behavior

Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit.

In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

Longevity at Last

While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of living longer. An added benefit: By staying healthier, your old age won't only be longer, it will be more enjoyable, too.

And, who knows, if you hang around long enough, taking your nutrients and getting a comfortable amount of consistent exercise, while meditating and refusing to succumb to stress, that magic bullet that will keep you alive for centuries may be discovered. Some day a new antioxidant or other substance may finally prove to provide the elusive fountain of youth. Stay tuned.

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Vitanet ®

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Date: June 06, 2005 08:23 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Resveratrol - New Hope for Long Life ...

Resveratrol

We all want to live long, vibrant and healthy lives. At one time intervention in the aging process was regarded as mere fantasy—but today it is within our reach due to breakthroughs in nutritional science. Resveratrol, a compound that is abundant in red wine, has been making headlines recently for its anti-aging potential and its well-documented antioxidant and cardiovascular benefits. Resveratrol has been shown in new research at Harvard Medical School to increase the lifespan of yeast cells—a finding that may help explain the lifeextending effects of the Mediterranean diet. Now Source Naturals offers you RESVERATROL from a non-alcoholic source. RESVERATROL is part of Source Naturals’ extensive line of scientifically based nutrients, designed to help you shape a successful anti-aging program.

Resveratrol in the News

Researchers at Harvard Medical School recently made headlines when they identified a plant molecule they believe may hold the key to slowing the human aging process. The compound, resveratrol, is produced by grapevines and other plants in response to environmental stress. The groundbreaking study, reported in the journal Nature, showed that resveratrol mimics the life-extending effects of calorie restriction and increases the lifespan of yeast cells by up to 80%. Resveratrol was found to activate certain enzymes that influence the genes that regulate aging. This research may help explain the long-established association between moderate red wine consumption and cardiovascular health and longevity.

Wide-Ranging Anti-Aging Benefits

Previous research has documented resveratrol’s many health benefits:

A Non-Alcoholic Source

Most publicity about resveratrol focuses on its presence in grape skins and red wine. However, this beneficial compound is found in other plants. Source Naturals RESVERATROL is a standardized extract of Hu Zhang root, a celebrated traditional Chinese herb. This offers consumers the advantage of a non-alcoholic source. Each tablet contains 500 mg of Hu Zhang extract, yielding 40 mg of resveratrol activity. RESVERATROL is available in bottles of 30 or 60 tablets.

Nature’s Protectant

Source Naturals, the science company, is pleased to partner with your natural foods retailer in bringing you this botanical treasure. For a long and vital life, RESVERATROL belongs at the center of your anti-aging regimen.

References:
Bowers, J.L. et al. 2000. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinol. 141(10):3657-67. Fustier, P. et al. 2003. Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines. Brit J Cancer. 89(1):168-72. Howitz, Konrad T. et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. (Published online 8/24/03 in advance of print publication) Jang, M. et al. 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275(5297):218-20. Pace-Asciak C.R. et al. 1996. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta. 246(1-2):163-82.

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VitaNet®
VitaNet ® Staff

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=192)

Date: June 02, 2005 11:37 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Hangover Formula - Fight Hangovers with this formula...

Whether you plan to “tie one on” during a holiday, or just sip a little wine with dinner, you should be aware that you may experience a form of low-level toxicity. When you drink, your body converts alcohol into toxic by-products, especially one called acetaldehyde. These toxins cause free radical damage and other problems, and are to blame for the hangover experience. HANGOVER FORMULA from Source Naturals may help to prevent and relieve some of the causes of hangovers. Its potent combination of antioxidants and Western and Chinese herbs is designed to help neutralize the negative effects of alcohol and replenish the nutrients it destroys.

Fight Free Radicals

Acetaldehyde causes the creation of free radicals, which can disrupt cellular activities throughout your body. This causes damage that accumulates with continued use, and is particularly threatening in its effect on the liver. But research shows that Vitamins C and E, and the amino acid Cysteine, act as an antioxidant force to counter the acetaldehyde-produced free radicals, helping to protect against long-term damage. HANGOVER FORMULA provides substantial amounts of these nutrients, and includes Cysteine both in its free form and as the powerful N-Acetyl Cysteine.

Help Counteract the Energy Drain

Acetaldehyde also poisons the energy-generating processes in our cells, the Krebs and glycolytic cycles. It breaks down the protein fraction of enzymes needed to keep these energy generation cycles going. It also damages enzymes that help carry nutrients through the intestinal walls, and others used by the liver to activate vitamins so they can be used in the body. This destruction of critical enzyme systems causes the intense fatigue and the feeling of literally being poisoned that are associated with hangovers and with too much drink, too fast. HANGOVER FORMULA provides the vitamins and minerals necessary to replace the damaged enzymes and keep the Krebs and glycolytic energy cycles going. The result? You feel better — stronger and healthier — than you might otherwise.

Guard Against Severe Depletion of Critical Vitamins and Minerals

Alcohol impairs absorption of a wide range of essential vitamins and minerals by the intestines. Many of the vitamins at particular risk are BVitamins such as B1, or Thiamine. Alcohol also disrupts the kidneys’ ability to conserve the mineral Magnesium, which is then flushed out in the urine. To help reduce the risk of severe depletion, HANGOVER FORMULA provides two of the principal minerals related to nerve function — Calcium and Magnesium — plus substantial amounts of all the B-Vitamins, with an especially high level of Thiamine.

The Acetylcholine Connection

Another major effect of alcohol in the body is the destruction of acetylcholine, one of the body’s most important neurotransmitters. HANGOVER FORMULA includes Phosphatidyl Choline, Choline Bitartrate, and DMAE (dimethylaminoethanol), which are precursors for acetylcholine. Alcohol also causes the brain’s sensitive cell membranes to get very “puffy” (or “fluidized” in scientific terms). This is followed by a rebound effect, and thecell membranes get too “thin,” which can result in a lack of coordination and focus. The acetylcholine precursors in HANGOVER FORMULA also help restore the normal levels of fluidity to these cell membranes, and assist in clearing and focusing the mind again.

Herbal Approaches

Naturopaths worldwide address hangovers with cleansing herbs that help the body regain its natural balance. HANGOVER FORMULA employs a sophisticated selection of these powerful herbs. Chinese Herbology contributes Pueraria Flowers (Ko Hua), specifically to cleanse; Magnolia Bark (Hou Pu), to relieve food stagnation; and Gastrodiae Root (Tien Ma), to relieve tension and excessive “liver yang.” Western Herbology provides Gravel Root, Slippery Elm, and Peach Leaves to restore fluid balance, plus Fennel Seeds, Cloves, and Mint to enhance assimilation. Other herbs of benefit include Germinated Rice, Crysanthemum Flowers, Marshmallow Root, and most importantly, Feverfew Leaf and Milk Thistle Seeds. Numerous studies in the scientific publication Lancet have demonstrated the amazing efficacy of the Feverfew Leaf. This traditional herbal remedy apparently helps to block the effects of hormone-like biochemicals called leukotrienes, which — when out of control — cause intense discomfort, until the body can once again get in balance. Three tablets of HANGOVER FORMULA provides 100 mg of a very potent Feverfew Extract. Silymarin, an extract of Milk Thistle Seeds, is the most popular herb in Germany for the liver. It helps keep this major cleansing organ in optimal working order by fighting free radicals and thus minimizing damage. In addition, Silymarin enhances the unique self-regenerative properties of the liver by helping accelerate repair when damage has been done.

Complete Nutritional & Herbal Support

To counter nutrient depletion and ease discomfort during hangover miseries, HANGOVER FORMULA is here to help.

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VitaNEt ®
VitaNet ® Staff

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=153)

Date: May 19, 2005 09:29 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: KudZu, Treatment of alcohol dependence or alcohol abuse

For millennia, folk medicines have been used to treat ‘‘alcohol addiction’’ in China. A thorough literature search of the ancient Chinese pharmacopoeias revealed a long list of traditional remedies, including the 16 ‘‘stop-drinking’’ formulae of Sun Simiao (ca. 600 AD) and the ‘‘anti-alcohol addiction’’ formula of Li Dongyuan (ca. 1200 AD), 2 of the most reputed ‘‘medical doctors’’ in the history of Traditional Chinese Medicine. However, like those discovered by the ancient Romans,11 most of the ancient Chinese remedies for ‘‘alcohol addiction’’ were based on psychological aversion: to deter patients from further drinking by associating alcohol drinking with an unpleasant experience. Interestingly, as time went by, treatments based solely on psychological aversion were gradually eliminated from the ancient Chinese pharmacopoeias, presumably because of their ineffectiveness and/or undesirable side effects. The only remedies that have survived this historical trial-anderror scrutiny are those consisting the root (Radix puerariae, RP) or flower (Flos puerariae, FP) of Pueraria lobata (a medicinal plant known to the West as kudzu). It was on the basis of this historical backdrop, we initiated the search of safe and efficacious anti-dipsotropic (alcohol intake suppressive) agents from RP. This approach has led to the discovery of daidzin,12 an isoflavone that has since been shown to reduce alcohol drinking in all alcohol preferring animal models tested to date.

Alcohol abuse

Alcohol abuse and alcohol dependence (i.e., alcoholism) are serious public health problems of modern society. In the United States alone, an estimated 13 million adults exhibit symptoms of alcohol dependence due to excessive alcohol intake, and an additional 7 million abuse alcohol without showing symptoms of dependence according to U.S. Government projections from studies conducted in the mid-1980s. Alcohol dependence and abuse are very expensive: in economic and medical terms, it will cost the U.S. well over $200 billion in 1991 with no prospect of falling or leveling off. The social and psychological damages inflicted on individuals as a consequence of alcohol abuse, e.g., children born with fetal alcohol syndrome (FAS) and victims of alcohol-related accidental death, homicide, suicide, etc., are immense.

While it is generally accepted that alcoholism and alcohol abuse are afflictions with staggering international economic, social, medical, and psychological repercussions, success in preventing or otherwise ameliorating the consequences of these problems has been an elusive goal. Only very recently the public view that alcoholism and alcohol abuse are remediable solely by moral imperatives has been changed to include an awareness of alcoholism and alcohol abuse as physiological aberrations whose etiology may be understood and for which therapy may be found through scientific pursuits. Both alcohol abuse and dependence arise as a result of different, complex, and as yet incompletely understood processes. At present, alcohol research is in the mainstream of scientific efforts.

Our studies on alcohol (ethanol or ethyl alcohol) have been based on the hypothesis that its abuse can ultimately be understood and dealt with at the molecular level. Such a molecular understanding, if achieved, would provide a basis for the identification and development of appropriate therapeutic agents. Our view hypothesizes that the clinical manifestations of alcoholism and alcohol abuse are the consequence of aberrations or defects within one or more metabolic pathways, affected by the presence of ethyl alcohol. In order to test this hypothesis, our initial studies focused on physical, chemical, and enzymatic properties of human alcohol dehydrogenase (ADH), the enzyme that catalyzes alcohol oxidation according to the following reaction formula:

CH.sub.3 CH.sub.2 OH+NAD.sup.+ .fwdarw.CH.sub.3 CHO+NADH

In addition, our studies more recently have focused on the aldehyde dehydrogenases (ALDH) which catalyze the subsequent step in the major pathway of ethanol metabolism according to the following reaction formula:

CH.sub.3 CHO+NAD.sup.+ .fwdarw.CH.sub.3 COOH+NADH

Prior to our research (for example, see Blair and Vallee, 1966, Biochemistry 5:2026-2034), ADH in man was thought to exist in but one or two forms, primarily in the liver, where it was considered the exclusive enzyme for the metabolism of ethanol. Currently, four different classes of ADH encompassing over twenty ADH isozymes have been identified and isolated from human tissues. There is no reason to believe that all of these ADH isozymes are necessary to catalyze the metabolism of a single molecule, ethanol, even though all of them can interact with it. We have proposed that the normal function of these isozymes is to metabolize other types of alcohols that participate in critical, physiologically important processes, and that ethanol interferes with their function (Vallee, 1966, Therapeutic Notes 14:71-74). Further, we predicted that individual differences in alcohol tolerance might well be based on both qualitative and quantitative differences in isozyme endowment (Vallee, 1966, supra).

Our research has established the structures, properties, tissue distribution, and developmental changes for most of the ADH isozymes, which while structurally quite similar, and presumed to have evolved from a common precursor, are functionally remarkably varied. Of the more than 120 publications from our laboratory that relate to the above subjects, the following, arranged in six categories, are especially useful for instruction in the prior art.