Search Term: " policosanol "

	Researchers look at the potential of rice bran in treatingcardiovascular disease	VitaNet, LLC Staff	8/31/18
	Protect Your Heart with Wheat Germ Oil	Darrell Miller	5/26/11
	Policosanol, Cholesterol and how its tied together	Darrell Miller	1/27/11
	Policosanol and The Heart!	Darrell Miller	1/22/11
	Atherosclerosis and Policosanol	Darrell Miller	7/31/10
	Lower Cholesterol Naturally!	Darrell Miller	10/6/06
	Sytrinol 150mg - Now Vitamins	Darrell Miller	8/29/06
	HDL Booster - Boost your good cholesterol	Darrell Miller	3/16/06
	Policosanol Cholesterol Complex	Darrell Miller	2/3/06
	Cholesterol Support FAQ's	Darrell Miller	1/6/06
	Policosanol and Nattokinase together!	Darrell Miller	12/31/05
	Psyllium Husk Fiber Fact Sheet	Darrell Miller	12/8/05
	Macadamia Nut Oil Fact Sheet	Darrell Miller	12/7/05
	Sytrinol can lower Cholesterol by 27% - 34%	Darrell Miller	9/20/05
	New* Improved formula - Cholest-Response Lower Cholesterol	Darrell Miller	7/8/05
	SYTRINOL - For Heart Health, Don’t Be Confused About Cholesterol...	Darrell Miller	6/29/05
	*New -- Policosanol 20MG - from Source Naturals	Darrell Miller	6/17/05
	Go Deep to the Underlying Cause of Symptoms*	Darrell Miller	5/31/05
	Policosanol and cholesterol control ...	Darrell Miller	5/17/05
	Under-Reported (and Underappreciated) Cholesterol control.	Darrell Miller	5/12/05
	Re: Its in the Blood	Darrell Miller	5/9/05
	Re: Read more on how to Lower Cholesterol safe and naturally!	Darrell Miller	5/9/05

Date: August 31, 2018 09:53 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Researchers look at the potential of rice bran in treatingcardiovascular disease

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Date: May 26, 2011 02:04 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Protect Your Heart with Wheat Germ Oil

Wheat Germ And Heart Health.

Wheat germ oil can protect your heart and entire cardiovascular system from damage, particularly from the effects of cholesterol and conditions such as peripheral artery disease. Atherosclerosis is a condition caused by the free radical oxidation of LDL cholesterol that is then precipitated and deposited onto your interior artery walls. This eventually blocks your arteries, causing strokes and heart failure depending on where the affected arteries are situated. Peripheral artery disease (PAD) is a condition where the arteries in your legs are blocked or partially blocked so that blood cannot reach your feet. This causes infections and pain.

By taking wheat germ oil, you can zap the free radicals before they can do damage to your cholesterol and hence to your arteries, and also prevent PAD the same way. The policosanol, another component of the oil, helps with this by increasing the proportion of HDL (good cholesterol) to LDL - bad cholesterol. There is then less LDL to undergo free radical oxidation, making the work of the antioxidants protecting it much easier.

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Date: January 27, 2011 10:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: policosanol, Cholesterol and how its tied together

Cholesterol is a fatty substance that is essential to your health! If that sounds contrary to what you have been hearing about cholesterol, then you don't have all the information. Cholesterol is essential for the synthesis of hormones in your body, including the steroidal hormones such as the sex hormones and those that regulate your blood sugar. So you cannot afford to eliminate all cholesterol. However, you can reduce it, and you can also take steps to reduce the problems that cholesterol can cause.

You have likely heard of LDL (bad) and HDL (good) cholesterol - there is no such thing as bad or good cholesterol. Without 'bad' cholesterol you would not be alive! However, cholesterol is not soluble in water, so cannot pass round your bloodstream by itself. LDL stands for Low Density Lipid, which is a fatty substance that can attach to cholesterol and act as a type of ferry, to carry it around your blood.

The problem is that LDL is easily oxidized by the free radicals formed by your metabolism and breathing in traffic and industrial emissions. This causes it to release the cholesterol that then sinks and deposits as a plaque on the inside of your arteries, eventually blocking them and causing strokes and heart attacks. The HDL cholesterol is responsible for carrying the unused cholesterol back to your liver, so does not block your arteries.

policosanol can reduce the amount of LDL cholesterol while still maintaining sufficient for your needs. It can also increase the HDL cholesterol: if more High Density Lipids that are not oxidized are available, then more cholesterol can be carried by them, and also possibly reduce the plaque build-up. This is what policosanol does: it reduces LDL and increases HDL cholesterol.

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Date: January 22, 2011 11:40 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: policosanol and The Heart!

What is policosanol To The Heart

policosanol is a mixture of the alcohols hexacosanol, octacosanol and tricontanol (mesityl alcohol) and a few others, although octacosanol is the major alcohol in the mixture. It is an extract of plant waxes from beeswax, yams, sugar cane and others, and is used a supplement to lower LDL cholesterol. In so doing it reduces your chances of contracting atherosclerosis, a condition associated with narrowing of the arteries through deposition of cholesterol on their inside walls.

Two studies carried out using policosanol with 22 people over 8 weeks and 437 people over 12 weeks have indicated a 21% and 28% increase in HDL cholesterol respectively, and a 25% reduction in LDL cholesterol in each study. LDL cholesterol is the form that is carried by the arteries to where it is needed to biosynthesize hormones such as testosterone and to act as a band aid for damage to the blood vessels, and HDL cholesterol is the form that is being returned to the liver for disposal.

It is the LDL form that is oxidized by free radicals and deposited on the walls of the arteries, eventually blocking them (atherosclerosis) and causing strokes and heart attacks according to whether the arteries affected were in the brain or close to the heart. If you are pregnant or nursing, then do not use policosanol without seeking the advice of your doctor.

Statins or policosanol?

Should you use statins or policosanol to reduce your cholesterol levels? High cholesterol levels can cause high blood pressure and heart attacks. Statins are used to reduce cholesterol levels, but have their problems: they can cause depression, memory problems, sexual dysfunction, joint pain, changes in your liver and more. Some people would rather suffer high cholesterol that take statins! policosanol, a mixture of various plant long-chain alcohols extracted from beeswax, sugar cane and yams plus some others, is a viable option to statins.

Tests have indicated that policosanol can make a significant difference to your LDL cholesterol levels - LDL is commonly known as 'bad' cholesterol, and is what cause most of the heart disease and strokes associated with high cholesterol levels. A policosanol supplement is accepted by many doctors and medical practitioners as being a genuine alternative to statins, and if statins cause you problems, or if you are afraid of taking them, policosanol could be your answer. Pregnant women and nursing mothers should not take any supplement without referring to their doctor.

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Date: July 31, 2010 02:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Atherosclerosis and policosanol

policosanol has been proposed as a treatment for a condition known as atherosclerosis, and prior to discussing the supplement and how it works, we shall first discuss the condition and what causes it. Cholesterol has a bad name, yet without it you could not live. Among its uses are the formation and maintenance of cell membranes, the production of hormones such as testosterone, its use by the liver as a raw material for bile and the metabolism of the fat-soluble vitamins, A, D, E & K. It also helps protect the arteries from damage.

So cholesterol is necessary. However, it is only sparingly water soluble, and has to be transported by large fatty molecules that are also water soluble: low density and high density lipids (LDL and HDL cholesterol). LDL lipids generally carry cholesterol in the blood to the areas of the body where it is needed, while the HDL lipids carry it back to the liver for metabolizing. Free radical oxidation of LDL lipids causes them to deposit on arterial walls, and progressively block them leading to atherosclerosis. Even small blood clots can block the arteries leading to stoppage of the heart or strokes if the artery is in the brain.

policosanol is a supplement, obtained in the USA from fatty alcohols extracted from beeswax and wheat germ, and in Cuba from other plant waxes, that is believed to reduce this problem and possibly even help to reduce the extent of atherosclerosis. HDL lipids can also reduce the extent of LDL arterial plaques. Studies are still under way, although the known side effects are only slight and many claim that policosanol has improved their condition substantially.

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Date: October 06, 2006 09:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Lower Cholesterol Naturally!

Because of organizations like the American Heart Association (AHA), we’ve learned a lot about cholesterol and how it affects our health. Thanks to these educational organizations, we know that high cholesterol levels can increase our risk for heart attacks and strokes and, by lowering these levels, we reduce these risks as well as keep our hearts and blood vessels healthy. We also know that our cholesterol levels can be improved through exercise, diet, and weight loss.

Although we’ve learned a lot through these educational organizations, there are still a few misconceptions about cholesterol. One of these being that not all cholesterol is harmful. There are both “good” and “bad” forms of cholesterol and a good balance between the two is what is needed for a healthy heart. Because so much emphasis is placed on lowering “bad” cholesterol levels, not enough attention is paid to the benefit of raising “good” cholesterol levels (HDL). Research states that raising HDL levels can provide even greater protection against cardiovascular disease than just simply lowering “bad” cholesterol levels. By raising HDL levels by simply 1%, the risk of heart disease can be lowered by 2% in men and 3% in women. Many studies have shown that low HDL cholesterol levels are an independent risk factor in heart disease. This is extremely important because we’ve learned that despite efforts to change a person’s diet and exercise habits, some people’s cholesterol levels are still unhealthy.

Prescription drugs to lower cholesterol are now available and have been proven by multiple studies to be very successful. The statins’ effectiveness in reducing LDL (“bad”) cholesterol has produced highly significant reductions in heart attacks and strokes. Although these medications do lower cholesterol levels, their side effects must be considered. Statin drugs can cause liver irritation, reduce CoQ10 levels in the body, are associated with myopathy, and are even linked to a rare and sometimes fatal condition called rhabdomyolysis. These drugs also have a relatively small effect on good (HDL) cholesterol levels. Thankfully, there are safe and effective solutions available that can help you manage your cholesterol levels naturally. However, first we must review what we know about cholesterol and heart disease.

Cholesterol is a fat-like substance needed to help digest fats, strengthen cell membranes, make hormones and insulate nerves. Although it is found in every cell of the body, cholesterol is mainly made in the liver, as well as cells lining the small intestine. Even though our bodies make all the cholesterol we need, we also get cholesterol from the foods we eat, such as egg yolks and organ meats. All foods from animal sources contain cholesterol, while plant derived food, including peanut butter and avocado, contains no cholesterol at all.

Cholesterol is important to many functions of the body. However, too much cholesterol in the bloodstream is extremely dangerous. After blood cholesterol reaches high levels, it builds up on the artery walls, and thus increasing the risk for blood clots, heart attack, and stroke. If the cholesterol clogs any of the coronary arteries, the heart’s supply of oxygen and nutrients will diminish, resulting in coronary heart disease, angina, or even heart attack.

Because cholesterol and other fats can’t dissolve in the blood and thereby can’t travel on their own, they have to be transported to and from the cells by lipoproteins. The two major lipoproteins are low density lipoproteins (LDL or “bad cholesterol) and high density lipoproteins (HDL or “good cholesterol”) LDLs carry cholesterol throughout the body to the cells and cause artherosclerosis by clogging up our arteries with fat. On the other hand, HDL prevents the fat buildup by carrying it away from the arteries and to the liver where it can be eliminated. Although high levels of LDL are associated with cardiovascular disease, high HDL can drastically reduce your risk of heart disease. As a result, the AHA has established three guidelines to keep your heart healthy: HDL levels about 40 for men and above 50 for women, LDL levels between 100 and 159, and a total cholesterol (HDL and LDL) of under 200.

Triglycerides are fats used as fuel by the body and a source for metabolism. These levels can fluctuate easily but increased levels are almost always a sign of too much carbohydrate and sugar intake. High amounts of triglycerides make the blood less capable of transporting oxygen and are another factor for cardiovascular disease. Thankfully, the HDL and LDL blend mentioned earlier can safely and effectively lower triglyceride levels.

It has been shown that high levels of HDL cholesterol are inversely related to coronary artery disease risk. However, what people do not know is that there are different subtypes of HDl, including HDL-2 and HDL-3. HDL-3 is produced by the liver and intestines and is responsible for scooping up free cholesterol from the blood vessel walls. The cholesterol carried by HDL-3 is chemically modified, forming a larger-sized subtype, known as HDL-2, or “mature HDL.” HDL-2 transports cholesterol to the liver for processing and elimination, and its molecules are then recirculated in the blood stream. Research has shown that HDL-2 provides more heart-protection because it moves the cholesterol away from arterial walls, and holds a greater number of receptor sites which allows it to carry a larger amount of cholesterol to the liver.

Although many prescription medications have been developed to lower bad cholesterol, there are very few medications that target good cholesterol. Therefore, patients with naturally low HDL cholesterol, who can not alter these levels through diet and exercise, have limited medical options to reduce their risk of heart disease. Multiple nutrients have been clinically shown to favorably alter good cholesterol levels including: vitamins C, E, B6, B12, niacin, folic acid, magnesium and selenium, with protein-building amino acids, powerful antioxidants such as coenzyme Q10, alpha lipoic acid, N-acetyle cysteine, and policosanol, and extracts of hawthorn, garlic, grape seed, and soy isoflavones. Although this HDL-boosting combination does not result in a significant reduction in LDL, antioxidants found in this formulation can help stabilize LDL and prevent build up in the arterial wall.

This formula combines essential vitamins and minerals, at levels recommended by the American Heart Association. It contains amino acids, antioxidants, and botanicals that have all been used safely for years. No serious adverse effects have been found following supplementation and the combination is safe to use with statin drugs.

Plant sterols, found in nuts, vegetable oils, corn, and rice are structurally similar to cholesterol and are able to block its absorption. Each day the liver receives about 800 mg of cholesterol from intestinal absorption through receptor sites. After entering these channels, the cholesterol is absorbed into the bloodstream. Since plant sterols look similar to cholesterol, they fit perfectly into these receptor sites and block the absorption, which allows the cholesterol to remain in our intestines where it can eventually be excreted. A large amount of plant sterols reduces the amount of cholesterol transported from the intestinal tract to the liver. This cholesterol reduction causes a decrease in LDL levels.

Even if a person does not have high cholesterol levels, reducing bad and raising good cholesterol greatly reduces their risk for ever developing chronic heart disease. Due to side effects, physicians do not normally prescribe statin drugs to people without actual heart disease of high LDL cholesterol levels. Instead, they recommend dietary changes. The HDL-boosting combination and LDL-lowering pantethine and plant sterols blend can effectively help people with heart disease, uncontrolled cholesterol levels, high triglyceride levels, or people who just want to improve their heart health.

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Date: August 29, 2006 03:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Sytrinol 150mg - Now Vitamins

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Date: March 16, 2006 12:51 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: HDL Booster - Boost your good cholesterol

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Date: February 03, 2006 03:50 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: policosanol Cholesterol Complex

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Date: January 06, 2006 12:15 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Cholesterol Support FAQ's

Cholesterol Support FAQ's What ingredients does NOW® Cholesterol Support contain, and how many capsules should I take daily? NOW® Cholesterol Support is specially formulated to support your body’s normal metabolization of cholesterol. This supplement contains essential nutrients like Vitamins C & E, and Tocotrienols derived from natural source Vitamin E. The active ingredients include Chromium, Guggul Extract, and PureGar® Garlic, specialized dietary ingredients that work synergistically to support healthy cholesterol metabolism. Has the formula for NOW® Cholesterol Support been changed? Recently the U.S. FDA ruled that Red Rice Yeast extract has a drug effect on the body and has banned dietary supplements from containing this ingredient. In order for NOW® to continue to offer Cholesterol Support with Red Rice Yeast extract, we would have to register this supplement as a drug, which would entail years of clinical trials. Due to the complications associated with this ingredient, NOW® has decided to reformulate this top seller. We’ve increased the levels of certain key nutrients to account for the absence of Red Rice Yeast extract, and this new formulation is as effective as the original. Disclaimer: This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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Date: December 31, 2005 09:33 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: policosanol and Nattokinase together!

Two HOT Ingredients Together For the First Time!

policosanol and Nattokinase

23 mg policosanol
100 mg Nattokinase

Nature's Life policosanol is standardized to 95% Total Aliphatic Alcohols including 50% Octacosanol. Our Nattokinase supplies 1250 Fibrinolytic Units. It is the perfect addition to healthy diet and daily exercise.

• policosanol Extracted from Sugar Caon wax - 50% Octacosanol
• Nattokinase derived from natural fermentation of soybeans.

Natures Life Feel the Energy of the Sun!

Supplement Facts:
Serving Size: 2 tablets
Servings per container 25

Nattokinase (Soy bean Fibrinase)(Supplying 1250 FU [Fibrionlytic Units]) - 100mg
policosanol (from Sugar Cane)(Standardized to 95% Total Alcohols including 50% Octacosanol) - 23mg

Other ingredients:

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Date: December 08, 2005 04:28 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Psyllium Husk Fiber Fact Sheet

Psyllium Husk Fiber Fact Sheet

LIKELY USERS: People with cholesterol or cardiovascular concerns.1-2 People wanting to increase fiber in their diet3-9

KEY INGREDIENTS: Psyllium Husk Powder, natural flavor

MAIN PRODUCT FEATURES: Psyllium is a true dietary fiber, even though it is classified by some as a laxative or mucilaginous fiber, and is a convenient way to increase intake of dietary fiber because of its high mucilage content. This bulking agent swells considerably when added to liquid, which can help to increase gastrointestinal transit time. This bulking action and increased transit time can play an important role in maintaining healthy gastrointestinal function.3-9 The FDA allows a health claim for products like psyllium husk that provide significant amounts of soluble fiber: Diets low in saturated fat and cholesterol that include 1.7 grams of soluble fiber per day from psyllium husk may reduce the risk of heart disease. One serving of NOW Psyllium Husk Fiber - Orange Flavored provides 2 grams of this soluble fiber.1-2

ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: This product has been tested by an independent laboratory to assay the fiber content. This is a vegetarian/vegan product.

SERVING SIZE & HOW TO TAKE IT: As a dietary supplement, mix 1 heaping teaspoon into at least 12 oz. of water or juice and consume immediately. Be sure to drink plenty of additional fluids throughout the day. Start with smaller amounts and gradually increase over several weeks.

COMPLEMENTARY PRODUCTS:

For GI tract: Triphala, Detox Support, Probiotics, FOS, and healthy oils (fish, flax, olive, virgin coconut, virgin macadamia)

For cardiovascular health: Hawthorn extract, Tru-E Bio Complex (new September 2005), Heart Support, Heart Renew, Cholesterol Support, Cholestatin, policosanol. Red Yeast Rice CAUTIONS: None.

SPECIFIC: Do not use if you have a bowel obstruction or an ulcer. If you have chronic constipation, diabetes or are obese a physician should monitor the use of this dietary supplement. Side effects are possible with any dietary supplement. This dietary supplement may cause gastrointestinal pain, flatulence and abdominal pain. Tell your doctor if these side effects become severe or do not go away.

NOTICE: This food should be eaten with at least a full glass of liquid. Eating this product without enough liquid may cause choking. Do not eat this product if your have difficulty in swallowing.

GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

REFERENCES:

1. [Code of Federal Regulations] [Title 21, Volume 2] [Revised as of April 1, 2002]
2. Jenkins DJ, Kendall CW, Vuksan V, Vidgen E, Parker T, Faulkner D, et al. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am J Clin Nutr. May2002;75(5):834-839.
3. McRorie JW, et al. Psyllium is superior to docusate sodium for treatment of chronic constipation. Aliment Pharmacol Ther. May1998;12(5):491-7.
4. Washington N, et al. Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation. Am J Clin Nutr. Feb1998;67(2):317-21.
5. Leib MS. Treatment of chronic idiopathic large-bowel diarrhea in dogs with a highly digestible diet and soluble fiber: a retrospective review of 37 cases. J Vet Intern Med. Jan2000;14(1):27-32.
6. Schwesinger WH, et al. Soluble dietary fiber protects against cholesterol gallstone formation. Am J Surg. Apr1999;177(4):307-10.
7. Davidson MH, et al. Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia. Am J Clin Nutr. Mar1998;67(3):367-76.
8. Jalihal A, et al. Ispaghula therapy in irritable bowel syndrome: improvement in overall well-being is related to reduction in bowel dissatisfaction. J Gastroenterol Hepatol. Sep1990;5(5):507-13.
9. Obata K, et al. Dietary fiber, psyllium, attenuates salt-accelerated hypertension in stroke-prone spontaneously hypertensive rats. J Hypertens. Dec1998;16(12 Pt 2):1959-64.

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Date: December 07, 2005 10:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Macadamia Nut Oil Fact Sheet

Macadamia Nut Oil Fact Sheet Neil E. Levin, CCN, DANLA 12/30/2004

LIKELY USERS: People following the Hampton’s Diet; Those wanting the benefits of olive oil with a more neutral flavor; People deep fat frying wanting the healthiest oil at high temperatures;

KEY INGREDIENT(S): 100% pure Macadamia Nut Oil, certified organic

MAIN PRODUCT FEATURES: Fat Compositon: 81% Monounsaturated, 3% Polyunsaturated, 16% Saturated Higher in healthy monounsaturated fats than any other oil, including olive oil; Macadamia Nut Oil has an ideal 1:1 ratio of Omega-3 vs. Omega-6 fats; A naturally high smoke point of 400-450 degrees makes this unrefined oil a versatile cooking oil. Trans Fatty Acids are much less likely to be created during cooking; Macadamia integrifolia is an unrefined, non-hybridized variety of Macadamia Nut (grown in Australia); Macadamia Nut oil is naturally high in vitamin E; Light, nutty, buttery flavor.

OTHER IMPORTANT ISSUES: Organically grown; Packed in a dark bottle that is not reactive with the oil at normal room temperature ranges

COMPLEMENTARY PRODUCTS: B-complex vitamins, garlic, fish oil, flax oil, olive oil, fiber, lecithin, plant sterols (phytosterols) and sterolins, Vitamin E (mixed tocopherols and tocotrienols), nuts, policosanols, chromium, Vitamin C, pantethine (a form of Vitamin B-5)

Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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Date: September 20, 2005 09:56 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Sytrinol can lower Cholesterol by 27% - 34%

Sytrinol – MultiPronged Heart Health

According to the American Heart Association, more than 60 million Americans suffer from on of more forms of cardiovascular imbalances. When we add in those individuals with blood cholesterol concerns, we see over 100 million Americans who may be in need of specific diet and lifestyle recommendations for achieving and maintaining heart health.

Aside from the generalized recommendations that we typically hear for heart health (lose weight, exercise more, and eat less fat and more fruits and vegetables) There are a number of potentially beneficial dietary supplements that may help to maintain cholesterol levels in the normal range. Among supplements there is a wide range of safety and efficacy between products—but a newer product called Sytrinol stands out for its clinical effectiveness.

Sytrinol is a patented blend of polymethoxylated flavones (from citrus) and tocotrienols (from palm fruit). One of the factors that sets Sytrinol apart from existing natural products for heart health is its multipronged approach to controlling multiple factors related to overall heart health—including control of cholesterol, cellular irritation, oxidation, triglycerides, and others.

Cholesterol Conundrum

While it is unarguable that cholesterol is an important contributor to overall heart health, it couldn’t be further from the truth that cholesterol is the “only” or even the most important factor when it comes to protecting your heart. Did you know that approximately HALF of all serious heart challenges each year are experienced by people with NORMAL cholesterol levels? If Cholesterol is not to blame, then what is?

In addition to total cholesterol levels (the “number” that you may know as 200 to 240 of other values in “mg/dl” units), we know how that LDL and HDL matter a lot (Low-density lipoprotein—the “bad” cholesterol, and High-density lipoprotein—the “good” cholesterol). We also know that some forms of the bad and LDL can be “Badder” than others—specifically those with lots of structural protein called “apolipoprotein B” (which tends to encourage LDL cholesterol to become embedded in your blood vessel linings—bad!). In addition to our total cholesterol, LDL, HDL, and the various apoproteins, we also need to know our triglyceride levels, our levels of cellular irritation, what our free radical load looks like, and what our antioxidant defenses are. Sytrinol addresses each of these important aspects of heart and health simultaneously.

The Sytrinol Solution

Polymethoxylated Flavones (PMFs) in Sytrinol are just what they sound like – flavonoid compounds with extra methoxy groups compared to “regular flavones. Like all flavonoids, the PMFs deliver potent antioxidant activity, but the PMF version is about three times more potent in its ability to address cholesterol levels (20% - 30% reduction in clinical Studies). The two primary PMFs are nobiletin and tangeretin.

In addition to the PMFs, Sytrinol contains palm tocotrienols—one of the most potent antioxidant nutrients known. An interesting effect of tocotrienols is a reduction in cholesterol synthesis in the liver—by a mechanism similar to (but safer than) the commonly utilized mechanism of inhibition of the HMG-CoA Reductase Enzyme.

Sytrinol is known to work via several unique mechanisms to reduce triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL). First, by reducing DGAT activity (Diacylglycerol acetyl transferase) and increasing liver PPAR (Peroxisome porliferator-activated receptor)—Sytrinol can reduce overall synthesis of TG (DGAT inhibition). The overall effect is to reduce TG levels in the blood by two complementary mechanisms.

In terms of LDL effects, Sytrinol also reduces both Apolipoprotein B levels (ApoB—needed for the synthesis of LDL particles) and MTTP levels (microsomal triglyceride transfer protein-needed to transfer fat into the new LDL particles). By reducing levels of both these tructural LDL components, Sytrinol reduces overall LDL levels, and thus total cholesterol levels, in the blood.

The clinical results behind Sytrinol are impressive—showing a reduction in levels of total, LDL, and triglycerides by 27% - 34% within 4 weeks. In one of these studies, ApoB levels were reduced (suggesting reduced LDL) and ApoA1 levels were increased (suggesting increased HDL)—as would be expected based on the biochemistry of PMFs and tocotrienols.

Sytrinol is also wonderfully safe—and at the effective dose of 300mg daily, users will benefit from its multipronged effects. One aspect of Sytrinol safety that I especially like is the finding that, unlike some flavonoids like naringin from grapefruit, there are no known risks of drug interactions with the form of citrus derived PMFs found in Sytrinol (certain grapefruit flavonoids can interfere with liver enzymes needed to metabolize many prescription drugs).

Summary

Not since Red Yeast Rice was removed from the market by the FDA, have we had a truly effective, multimechanism solution for cholesterol control (and nearly total heart health). There are certainly other options for addressing heart health and cholesterol levels, but among the available choices, such as policosanol, guggulipid, niacin, and plant sterols, we’re looking at about half the cholesterol-lowering ability (10% - 15% in most cases) compared to Sytrinol. If youre in the “borderline” zone of cholesterol levels (about 240mg/dl and below), you should absolutely consider Sytrinol to keep your cholesterol levels under control.

References

Kurowska EM, manthey Ja. Hypolipidemic effects of absorption of citrus polymethoxylated flavones in hamsters with diet-included hypercholesterolemia. J Argic food chem.. 2004 may 19;52(10):2879-86.

Kurowska EM, manthey Ja, Casaschi A, Theriault AG. Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, Tangeretin. Lipids 2004 feb;39(2):143-51.

Manthey JA, Grohmann K, Montanari A, Ash K, Manthey CL, Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human moncytes. J Nat Prod. 1999 mar;62(3)441-4.

Mora A, Paya M, rios JL, Alcaraz MJ. Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation. Biochem Parmacol. 1990 Aug 15;40(4):797-7.

Takanaga H, Ohnishi A, Yamada S, Matsuo H, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol exp. Ther. 2000 Apr;293(1):230-6.

By: Shawn M. Talbott, PH.D.

Disclaimer: The above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider. The information in this article has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Date: July 08, 2005 09:27 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: New* Improved formula - Cholest-Response Lower Cholesterol

New & Improved Formula!

? Bio-Aligned Formula™: supports multiple body systems including the heart, blood vessels, nervous system, thyroid, liver and gastrointestinal tract.

Serving Size:

4 tablets contain:
Vitamin C (as ascorbic acid) 600 mg
Vitamin E 16 IU
(from gamma-vitamin E complex)
Niacin (as inositol hexanicotinate) 500 mg
Iodine (from kelp) 150 mcg
Selenium (as L-selenomethionine [SelenoPure™] & sodium selenite) 100 mcg
Chromium (as chromium polynicotinate [ChromeMate®] & chromium picolinate) 100 mcg
Phytosterol Complex 40% 750 mg
Yielding 300 mg beta-sitosterol
Garlic Powder Extract 600 mg
(standardized to 8,000 ppm allicin)
Turmeric Extract 526 mg
Yielding 500 mg curcumin
gamma-Vitamin E Complex 500 mg
Inositol 350 mg
(as inositol and inositol hexanicotinate)
Red Yeast Rice 350 mg
Yielding 1.5% mevinolinic acid monacolins
Artichoke Extract 250 mg
(standardized to 2.5% cynarins)
L-Arginine (as L-arginine HCl) 240 mg
Methylmethioninesulfonium Chloride 200 mg
(vitamin U)
Green Tea Extract 105 mg
Yielding 100 mg polyphenols, 36 mg EGCG
Sytrinol™ 100 mg
(proprietary blend of citrus polymethoxylated
flavones and palm tocotrienols)
Soy Bean Concentrate 100 mg
Yielding 40 mg total isoflavones
Ginkgo Leaf 24% (50:1 Extract) 60 mg
Guggul Extract (10% guggulsterones) 50 mg
Dandelion Root Extract (4:1) 50 mg
Hawthorne Berry Extract (4:1) 50 mg
Myricetin 30 mg
policosanol 10 mg
Coenzyme Q10 5 mg

Suggested Use: Take 4 tablets each night or as recommended by your health care professional.

Code	Size	Retail	UPC Code
SN1271	30 tabs	$12.50	021078012719
SN1272	60 tabs	$23.50	021078012726
SN1880	120 tabs	$44.98	021078018803

We offer Source Naturals at 46% OFF Man. Suggested Retail

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SYTRINOL - For Heart Health, Don’t Be Confused About Cholesterol...

Date: June 29, 2005 09:44 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: SYTRINOL - For Heart Health, Don’t Be Confused About Cholesterol...

SYTRINOL - For Heart Health, Don’t Be Confused About Cholesterol...

Maintaining your cardiovascular health is one of the best ways you can stay fit. That means working to keep your cholesterol levels within the normal range. And contrary to popular belief, the amount of cholesterol you consume in food is not the most important factor for regulating normal cholesterol levels. It is actually the liver’s imbalanced production of cholesterol that is much more critical for your cardiovascular health.

You can address the root cause of maintaining normal cholesterol levels today with Source Naturals SYTRINOL™. This patented blend of citrus polymethoxylated flavones and tocotrienols has been clinically shown to promote cardiovascular health by supporting normal cholesterol production by your liver, promoting balanced triglyceride (fat) production, and providing antioxidant protection. Source Naturals, an industry leader in many categories, introduces the science of SYTRINOL™ in the CHOLESTEROL RESCUE™ product family to support your better heart health today.

The Truth About Cholesterol

Cholesterol is a very confusing subject – our bodies require it but we can also get too much of it. Cholesterol is one type of the ring-shaped compounds called sterols. Other sterols include bile acids, sex hormones, adrenal hormones and vitamin D. Approximately 90% of the cholesterol in your body is in your cell membranes. The remaining 10% can be found in your blood and throughout your body.

Liver’s Over-Production of Cholesterol

When your body needs more cholesterol, your liver takes carbohydrates, proteins and fats (also called triglycerides) from your diet and converts them into cholesterol. The amount of cholesterol that you might consume from foods (in animal products such as eggs, milk, cheese and beef ) is minute compared to the amount of cholesterol produced by your liver. Thus, cholesterol from food isn’t as critical to your total cholesterol. But balancing the cholesterol produced by your liver is very critical to your total cholesterol and thus, your cardiovascular health.

Oxidized LDL Cholesterol

Despite the confusion, cholesterol is a vital component of good health that strengthens cell membranes and provides building blocks for hormones, bile and vitamin D production. However, there is one potential pathway where cholesterol can contribute to an imbalance. When cholesterol moves through the blood to individual cells, it can travel in groups such as lipoproteins, which also contain fats and proteins. When the cholesterol is moving through your blood in Low Density Lipoproteins (LDL) it can undergo oxidation by free radicals in the artery walls. Some medical experts theorize that the oxidized LDL cholesterol becomes trapped in the artery walls as imbalanced deposits instead of completing the journey to join cell membranes. These deposits can eventually reduce the size and function of the arteries, compromising blood flow. Thus, antioxidant protection, balanced triglyceride production, and normal cholesterol production by the liver can all be critically important to your good health. And SYTRINOL™ provides all of these benefits.

How SYTRINOL™ Supports Heart Health

SYTRINOL is a powerful scientifically formulated blend protected by U.S. patent numbers 6,251,400, 09/ 481724. It contains natural citrus polymethoxylated flavones (PMFs) and tocotrienols that go deep to address the root causes of cholesterol wellness.

Citrus PMFs

Polymethoxylated flavones are types of polyphenolic compounds called flavonoids, which are the largest known category of phytonutrients. Health benefits of various flavonoids include antioxidant activity, immune system support, and cellular protection. The unique structure of polymethoxylated flavones, which naturally contain methyl groups paired with oxygen in key places, enables PMFs to interfere with cholesterol production. The citrus PMFs in SYTRINOL, such as tangeretin and sinensetin, promote normal cholesterol levels by inhibiting both the production of cholesterol precursors, such as cholesteryl esters, and the activity of HMG CoA Reductase, an enzyme that synthesizes cholesterol in the liver. These PMFs can also balance the body’s production of triglycerides by inhibiting the activity of your liver’s triglyceride producing enzyme, diacylglycerol acetyltransferase. Since LDL cholesterol is made from cholesterol and triglycerides, decreasing your liver’s production of triglycerides will reduce the amount of those triglycerides available to form LDL cholesterol compounds.

Tocotrienols

Tocotrienols are compounds similar to vitamin E in structure and function. The tocotrienols in SYTRINOL increase degradation of cholesterol building blocks such as Apolipoprotein B, interfere with cholesterol production, and provide antioxidant protection. The tocotrienols in SYTRINOL are also especially protective antioxidants for LDL cholesterol compounds that have already been produced, helping to prevent the oxidized LDL cholesterol conditions that may affect your cardiovascular circulation.

SYTRINOL’s Proactive Synergy

SYTRINOL works so well because this natural blend of PMFs and tocotrienols works proactively, synergistically, and independently. In preliminary human research, SYTRINOL proactively supported balanced cholesterol and triglyceride production by the liver through the synergistic effects of the PMFs and tocotrienols. Furthermore, SYTRINOL promotes LDL cholesterol antioxidant protection.

The above information has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Other products work reactively to disable existing cholesterol and may only work in conjunction with diets. And because SYTRINOL works independently of diet, you can take it anytime.

Three Lifestyle Strategies for Cardiovascular Health

1. Exercise regularly to increase hearthealthy HDL cholesterol and lower blood triglycerides (fats).

2. Eat a healthy diet rich in fruits, vegetables, whole grains, and lean proteins to help maintain normal cholesterol and triglyceride levels.

3. Take the right supplements to promote your cardiovascular health. In preliminary clinical studies, the amino acid L-ARGININE supported healthy blood flow to the heart and body. GARLIC OIL helps to maintain healthy cholesterol levels and promotes healthy circulation. policosanol CHOLESTEROL COMPLEX, CHOLESRESPONSE™, CHOLESFIBER™, CHOLESTREX®, and GRAPEFRUIT PECTIN all help to support normal cholesterol levels. HEART RESPONSE™ and HEART SCIENCE™ are advanced formulas that address heart health. Additionally, you can get cardiovascular system supporting compounds such as folic acid, betacarotene, CoQ10, lipoic acid, ginkgo, grapeseed extract, hawthorn extract, magnesium, vitamin E, and many other nutrients in LIFE FORCE MULTIPLE™, Source Naturals’ best-selling multiple. There is a revolution underway in natural health consciousness, and your local health food store is at the forefront. You can benefit right now – long before word spreads to the general public – with the innovative heart nutrition of SYTRINOL, a CHOLESTEROL RESCUE™ product. SYTRINOL™ is a trademark of KGK Synergize exclusively licensed worldwide to SourceOne Global Partners.

References
Guthrie, N. and Kurowska, E.M. (2000). Anticancer and Cholesterol-Lowering Activities of Citrus Flavonoids. Handbook of Nutraceuticals and Functional Foods, Wildman, R.E.C, Ed., CRC Press, Boca Raton, FL, 113-126. Guthrie, N. and Kurowska, E.M. (2000). Anticancer and Cholesterol-Lowering Activities of Tocotrienols. Handbook of Nutraceuticals and Functional Foods, Wildman, R.E.C, Ed., CRC Press, Boca Raton, FL, 269-280.

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*New -- Policosanol 20MG - from Source Naturals

Date: June 17, 2005 10:33 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: *New -- policosanol 20MG - from Source Naturals

NEW PRODUCT ANNOUNCEMENT policosanol 20 mg

Supports Cardiovascular Health!

policosanol studies

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Go Deep to the Underlying Cause of Symptoms*

Date: May 31, 2005 05:37 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Go Deep to the Underlying Cause of Symptoms*

Go Deep to the Underlying Cause of Symptoms*

Bio-Aligned Formulas Balance Your Body Systems

Source Naturals comprehensive Bio-Aligned Formulas go deep to address the root causes of nutritional symptoms*. Our expert formulators exhaustively review the latest scientific research on nutrition and health. Then they design scientifically based formulas that help bring alignment to your multiple, interdependent body systems. Only this in-depth formulation approach can bring you the most effective formulas possible.

Cardiovascular Symptoms*

Your heart function and circulation can be disrupted by factors including diet, stress, and free radicals. Bio-Aligned Formulas supply nutrients to meet the heart’s energy requirements, nutrients necessary for the maintenance of blood vessels, antioxidants to help control cholesterol oxidation, minerals to support normal electrical rhythms, vitamins for regulation of homocysteine levels, and fibers to help with the exertion of cholesterol. The following formulas help align these systems: CHOLES RESPONSE™, CHOLESTREX ®, HEART SCIENCE ™, and policosanol CHOLESTEROL COMPLEX ™.

Cognitive & Mood Symptoms*

Brain health can be affected by nutrition, lifestyle and environmental factors, leaving you susceptible to problems in memory, concentration, and perception. Bio-Aligned Formulas provide ingredients such as neurotransmitters for brain cell communication, phospholipids that are components of nerve cell membranes, nutrients to fuel the brain’s energy demands, and herbs for stress response. The following formulas help balance these underlying systems: ATTENTIVE CHILD™, CALM THOUGHTS ™ KAVA, HIGHER MIND ™, MEGAMIND ™, MENTAL EDGE®, NIGHT REST ™, POSITIVE THOUGHTS™, and VISUAL EYES™.

Digestive, Eliminative & Metabolic Symptoms* Without adequate nutrition, your liver can’t perform its critical functions: detoxification, metabolism, and conversion of vitamins into usable forms. Bio-Aligned Formulas provide antioxidants, herbs that detoxify and promote bile flow, ingredients for the liver’s energy needs, nutrients that support glucose metabolism and pancreatic activity, and digestive enzymes. The following formulas bring these systems into alignment: ESSENTIAL ENZYMES™, GLUCO-SCIENCE™, HERBAL RE:STORE™, and LIVER GUARD™.

General Symptomatic Conditions*

Daily well-being requires nutrition for your major body systems. While typical multiples supply just enough ingredients to meet minimum requirements, Bio-Aligned Formulas provide nutrients to support energy and liver function, heart-friendly botanicals, herbs that promote circulation to the brain, immune-supporting vitamins, minerals for your skeletal system, and antioxidants for general protection. These multiples bio-align your body systems: ÉLAN VITÀL™ MULTIPLE, and LIFE FORCE™ MULTIPLE.

Immune Symptoms*

Appropriate immune response is critical for seasonal health and wellness all year around—but it can be compromised by stress, lack of sleep, and poor diet. Bio-Aligned Formulas supply botanicals that modify histamine release, nutrients for the adrenals, clearing herbs, and antioxidants to defend white blood cells. The following formulas help bring these systems into balance: ALLERCETIN™, ALLER-RESPONSE™, CAT’S CLAW DEFENSE COMPLEX™, WELLNESS COLD & FLU™, WELLNESS COUGH SYRUP™, WELLNESS EARACHE™, WELLNESS FORMULA®, and WELLNESS MULTIPLE™.

Joint, Bone, and Muscular Symptoms*

Healthy joints, bones, and muscles require continuous nutrition. Bio-Aligned Formulas provide components of joint and connective tissue, bone-building minerals, soothing herbs, and nutrients that support muscular energy. The following formulas help align these systems: FIBRO RESPONSE™, GLUCOSAMEND™, MUSCLE MASS™, ULTRA-CAL NIGHT™, and ULTRA JOINT RESPONSE™.

Men’s & Women’s Symptoms*

The health of men and women can be impacted by diet, stress, and aging. Bio-Aligned Formulas provide phytoestrogens for hormonal balance, calming neurotransmitters, ingredients for metabolic support, and nutritional support for skin, hair, and nails. The following formulas help harmonize these systems: LUSTRE™, MALE RESPONSE™, MENOPAUSE MULTIPLE™, MONTHLY COMFORT™, MOOD BALANCE™, PROSTA RESPONSE™, SKIN ETERNAL PLUS™ and ULTRA BONE BALANCE™.

Choose Your Bio-Aligned Formula

In a world of dizzying consumer choices, shopping for the right supplement can leave you confused and frustrated. And since few companies disclose the rationale behind their formulas, it’s hard to make an informed choice. The best place to start is at your local health food store. The natural foods industry is unique in its dedication to holistic health, self-care and consumer education. And the Source Naturals Bio-Aligned Formulas Chart Book—now available at participating health food stores as well as online—is an invaluable tool. The Chart Book helps you pick the formula that is appropriate for your nutritional symptoms* by explaining how each formula supports specific, interdependent body systems. Source Naturals Bio-Aligned Formulas are expertly designed using groundbreaking nutrients, clinically substantiated potency levels, cofactors that facilitate the action of key ingredients, bioavailable forms, and effective delivery systems. Together, these ingredients can help bring you the power of Bio-Alignment.

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VitaNet ®
VitaNet ® Staff

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=124)

Date: May 17, 2005 06:25 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: policosanol and cholesterol control ...

In addition, after 30 days of therapy, 20 and 40 mg/day policosanol significantly ( P < 0.01) reduced low-density lipoprotein– cholesterol (15.9 and 17.0%, respectively) and total cholesterol (12.4 and 12.3%, respectively; P < 0.05), yet increased high-density lipoprotein–cholesterol values by 5% in both groups ( P < 0.05).

policosanol is a mixture of higher aliphatic primary alcohols purified from sugar cane ( Saccharum officinarum L) 4,5 wax, the main component of which is octacosanol, followed by triacontanol and hexacosanol; other alcohols (tetracosanol, heptacosanol, nonacosanol, dotriacontanol and tetratriacontanol) are minor components. The cholesterol-lowering effects of policosanol have been proven in healthy volunteers, 6,7 patients with type II hypercholesterolaemia 8–25 and in dyslipidaemia due to type II diabetes mellitus. 26,27

The hypocholesterolaemic effect of policosanol is associated with inhibition of cholesterol biosynthesis at a step located between acetate consumption and mevalonate production, although inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase has been discarded. 28–30 policosanol also increases low-density lipoprotein (LDL) receptor-dependent processing in fibroblast cultures, 28 as well as the clearance of [ 125 I]-labelled LDL–cholesterol (LDL-C) administered to rabbits with hypercholesterolaemia induced by a cholesterol-free casein-rich diet. 29

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Date: May 12, 2005 10:00 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Under-Reported (and Underappreciated) Cholesterol control.

Under-Reported (and Underappreciated) Solutions for Cholesterol and Triglyceride Control

Fat and human existence are inseparable. Setting aside the fear and loathing over fat in the body that pervades our culture, we understand that fat is our friend. We cannot live without fat.

The human body contains many different kinds of fats and fat-like molecules. Collectively known as "lipids" these fatty substances include fatty acids, lipoproteins, phospholipids, glycolipids, triglycerides, steroid hormones and the infamous, dreaded cholesterol.

Lipids (fats) are found everywhere in the body, performing a variety of vital functions. The brain is a fat-rich organ. Brain neurons and all other nerve cells are protected by a myelin sheath, made largely out of fatty material. Cell membranes consist almost entirely of phospholipids (lipids that contain phosphorus) arranged in a sandwich-like double layer embedded with proteins. Sex hormones are lipids, belonging to the group of complex lipid molecules known as "steroids." Vitamin D is a lipid.

The body stores and transports fatty acids in the form of triglycerides. A triglyceride contains three fatty acid molecules, which have a chain-like structure, linked to glycerol. (There are also mono- and di-glycerides, which have one and two fatty acid chains, respectively, attached to glycerol.)

Like many other things necessary to life, fat is a two-edged sword. Fat insulates us from the cold, cushions and protects our vital organs and serves as a storehouse for energy. Yet, when present in excess to the point of obesity, fat threatens health, happiness, self-esteem, social standing and longevity. The same is true of other lipids, most notably triglycerides and cholesterol. Transported throughout the body in the bloodstream, these essential lipids become a health liability when the blood contains too much of them.

Keeping fat in it its proper place, not eliminating or drastically reducing it, is the goal we should seek. In the blood, lipids must be maintained at healthy levels and ratios. When they are, an important foundation of good health is established.

How do we keep the blood lipids we need——triglycerides and the various forms of cholesterol——balanced at healthy levels? Diet and exercise are indispensable, these basics must come first. Along with the recommended dietary practices, a number of nutritional approaches offer help for maintaining healthy blood lipids. We will now give several of these a closer look.

Gugulipid

In 1990, an herb used for centuries in the Far East was introduced to U.S. consumers. This herb, called "gum guggul," is proving to be one of the most effective natural cholesterol-lowering agents ever discovered. It also brings triglycerides down and raises HDL, the "good" cholesterol. The changes are substantial; gum guggul single-handedly normalizes the entire blood lipid profile, even in people with high starting levels of cholesterol and triglycerides.

Gum guggul, also called simply "guggul," is a gummy resin tapped from the Commiphora tree. A cousin of myrrh gum, guggul has been used by Ayurvedic herbalists of India for at least 3,000 years; texts dating from around 1,000 B.C. mention the herb. Guggul was traditionally given for rheumatism and poor health caused by excess consumption of fatty foods. One ancient Sanskrit text describes in detail what happens in the body when blood fats are out of balance, due to sedentary lifestyle and overeating. The name of this condition has been translated as "coating and obstruction of channels."

Intrigued by the obvious similarity between "coating and obstruction of channels" and arteries clogged by fatty plaque, Indian researchers initiated a series of experimental and clinical studies in the 1960's to see if gum guggul would lower excess blood lipids.1 Both human and animal studies consistently showed cholesterol and triglyceride reductions.

Detailed pharmacological studies showed that guggul's lipid-lowering effects are produced by compounds in the resin called "guggulsterones."2 An Indian pharmaceutical firm then patented a standardized extract of gum guggul under the trade name "Gugulipid." The product contains a uniform 2.5 percent guggulsterones, which is higher than guggul resin in its natural state.

Because Gugulipid guarantees the necessary intake of guggulsterones needed for blood fat reduction, it has become the product used in clinical research. Phase I efficacy safety trials and Phase II efficacy trials have yielded more positive data.3,4,5 Most of the studies on gum guggul have used relatively small numbers of subjects; this tends to make mainstream medical scientists reluctant about natural remedies. A large, well-publicized double-blind Gugulipid trial on 400 to 500 people would go a long way toward giving this herb the credibility it deserves.

Pantethine

Another effective natural solution for blood fat control that should be better known is a relative of pantothenic acid (vitamin B5). Pantethine is the active form of pantothenic acid in the body. Pantethine forms CoA, an essential co-enzyme for utilization of fat. CoA transports "active acetate," an important byproduct of fat metabolism that provides fuel for generating cellular energy. By promoting the burning of fats for energy, pantethine helps keep triglyceride levels down.6 Pantethine also helps regulate cholesterol production, by facilitating the conversion of fat into other lipid-based molecules needed in the body.6

Japanese researchers began studying the effect of pantethine on blood fats nearly twenty years ago. They reported their promising results at the Seventh International Symposium on Drugs Affecting Lipid Metabolism, held in Milan, Italy in 1980.7 Few in the medical or scientific communities took notice. Italian researchers followed up with several small clinical trials that confirmed the preliminary reports.6,8,9 An excellent cholesterol and triglyceride lowering agent that is safe and free of side-effects, pantethine remains, for the most part, ignored by mainstream science, although its usage is growing in alternative medicine circles. Pantethine it will no doubt prove to be one of the most important supplements for maintaining healthy blood fat levels.

Niacin

When taken in high enough doses, niacin (vitamin B3) substantially lowers cholesterol. This has been known to medical science for many years.10 studies on niacin as a cholesterol-lowering agent go back to the 1950's. There was a fair amount of initial enthusiasm for niacin because it improves, unlike most lipid-lowering drugs, all parameters of the blood lipid profile. Niacin reduces total cholesterol, LDL cholesterol and triglycerides. It also raises HDL cholesterol quite well. Interest in niacin has faded, in part because the necessary dose, 1200 milligrams a day or more, can cause flushing and gastrointestinal disturbances. Very high doses may be harmful to the liver if taken for too long.

There is a solution to the side-effect problem with niacin which, again, has failed to gain widespread attention. Inositol hexanicotinate is a flush-free form of niacin composed of six niacin molecules bonded to one molecule of inositol, another B-complex nutrient. Absorbed as an intact structure, inositol hexanicotinate is metabolized slowly, releasing free niacin into the bloodstream over a period of hours following ingestion.11 Inositol hexanicotinate has all the benefits of niacin for controlling blood fats. The flushing effect of ordinary niacin, which metabolizes much more rapidly, does not occur. Taking as much as four grams per day has not been reported to raise liver enzymes or cause other side-effects, but prudence dictates that people with liver problems should avoid very high doses of inositol hexanicotinate, or any form of niacin.12

Tocotrienols

We often think of vitamin E as synonymous with d-alpha tocopherol. Vitamin E is actually a whole family of compounds that includes various tocopherols and a group of lesser known but highly beneficial substances called "tocotrienols." All have vitamin E activity. Tocotrienols are similar in chemical structure to tocopherols, but they have important differences which give them unique and highly beneficial properties for human health.

Vitamin E is one of the most recognized antioxidants, nutrients that deactivate potentially toxic byproducts of oxygen metabolism known as free radicals. Vitamin E neutralizes peroxides, which result from the free radical oxidation of lipids, making it a key antioxidant in cell membranes. While d-alpha tocopherol has generally been regarded as the form of vitamin E with the strongest antioxidant activity, tocotrienols are even stronger.

The tocotrienol story is another example of a natural product slow to gain recognition. A Univeristy of California research team discovered that d-alpha tocotrienol is over six times more effective than d-alpha tocopherol at protecting cell membranes against free radical damage.13 In the presence of vitamin C, which recycles vitamin E-like compounds, its antioxidant activity is 40 to 60 times higher than d-alpha tocopherol. This study was published in 1991. Its safe to say few cardiac physicians know about tocotrienols, and we have yet to see 60 Minutes do a piece on "the powerful new form of vitamin E."

It would be a tremendous service to public health if they did, because the benefits of tocotrienols go far beyond their stellar antioxidant ability. Tocotrienols also lower total cholesterol and LDL, by impressive percentages. In one double-blind controlled study, tocotrienols reduced total cholesterol by 16 percent and LDL by 21 percent after twelve weeks. Another study recorded drops of 15 to 22 percent in total cholesterol along with 10 to 20 percent decreases in LDL levels.14 Now appearing on health food store shelves, tocotrienols are a health-protecting nutrients whose long overdue time has come. Derived from food oils such as palm oil and rice bran oil, tocotrienols have the same lack of toxicity as ordinary vitamin E.

References

1. Satyavati, G. Gugulipid: a promising hypolipidaemic agent from gum guggul (Commiphora wightii). Economic and Medicinal Plant Research 1991;5:47-82.

2. Dev, S. A modern look at an age-old Ayurvedic drug—guggulu. Science Age July 1987:13-18.

3. Nityanand, S., Srivastava, J.S., Asthana, O.P. Clinical trials with gugulipid. J. Ass. Physicians of India 1989;37(5):323-28.

4. Agarwal, R.C. et. al. Clinical trial of gugulipid—a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986;84:626-34.

5. 'Gugulipid' Drugs of the Future 1988;13(7):618-619.

6. Maggi, G.C., Donati, C., Criscuoli, G. Pantethine: A physiological lipomodulating agent, in the treatment of hyperlipidemias. Current Therapeutic Research 1982;32(3):380-86.

7. Kimura, S., Furukawa, Y., Wakasugi, J. Effects of pantethine on the serum lipoprotiens in rats fed a high cholesterol diet (Abstract) Seventh International Symposium on Drugs Affecting Lipid Metabolism, Milan, Italy, 1980.

8. Arsenio, L. Bodria, P. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Clinical Therapeutics 1986;8(5):537-45.

9. Avogaro, P. Bittolo Bon, G. Fusello, M. Effect of pantethine on lipids, lipoproteins and apolipoproteins in man. Current Therapeutic Research 1983;33(3):488-93.

10. Crouse, J.R. New developments in the use of niacin for treatment of hyperlipidemia: new considerations in the use of an old drug. Coronary Artery Disease 1996;7(4):321-26.

11. Welsh, A.L. Ede, M. Inositol hexanicotinate for improved nicotinic acid therapy. International Record of Food Medicine 1961;174(1):9-15.

12. "Inositol hexaniacinate" (Monograph). Alternative Medicine Review 1998;3(3):222-3.

13. Serbinova, E., et. al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha tocotrienol. Free Radical Biology and Medicine 1991;10:263-275.

14. Qureshi, N. Qureshi, A.A. Tocotrienols: Novel Hypercholesterolemic Agents with Antioxidant Properties. in 'Vitamin E in Health and Disease' Lester Packer and Jürgen Fuchs, Editors. 1993; New York: Marcel Dekker, Inc.

Control Cholesterol with the following Supplements

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Date: May 09, 2005 06:10 PM
Author: Darrell Miller (dm@vitanetonline.com)

It's in the Blood

The National Cholesterol Education Program (NCEP) last July lowered the threshold for considering the use of statin drugs—a move which some say was motivated more by profits than scientific evidence. For example, the Center for Science in the Public Interest pointed out that eight of the nine authors behind the new recommendations had financial ties to statin manufacturers, which stand to reap billions of dollars more from a category that grossed $14 billion in the U.S. last year. And though the Food and Drug Administration (FDA) in January decided against authorizing over-the-counter (OTC) sales of statin drugs, drug companies would still like to see this happen.

“The medical establishment’s pushing of these drugs to becoming the number one category of prescribed drugs in the world has led them to keep lowering the total cholesterol number that triggers the drug recommendation,” said Neil E. Levin, C.C.N., D.A.N.L.A., nutrition educator, product formulator, and “Truth Advocate” for NOW Foods (Bloomingdale, IL), which produces a number of supplements for addressing cholesterol. “This is despite the lack of evidence that total cholesterol means much as regards cardiovascular risks.

“Other tests are much more important in terms of predicting risks, including CRP (C-reactive protein), the balance of different cholesterol fractions, and homocysteine,” he continued. “Add adult-onset diabetes to the risk factors for cardiovascular disease (CVD).”

At the same time, the allegation that enormous sales potential lay behind the lower threshold for prescribing statin drugs illustrates how widespread the problem of hypercholesterolemia (elevated total cholesterol) is. More than 100 million Americans have elevated cholesterol (total cholesterol values of 200 mg/dl and higher), and of these, more than a third have high cholesterol (levels of 240 mg/dl and higher), according to the American Heart Association. Those numbers have unfavorable implications for the incidence of CVD, as high cholesterol is considered a risk factor for coronary heart disease and stroke.

While statin drugs haven’t garnered the same degree of negative publicity that COX-2 inhibitors have suffered lately, safety concerns have arisen nonetheless. For one thing, these drugs lower the liver’s production of coenzyme Q10 (coQ10) along with its production of cholesterol. “CoQ10 is related to energy production and immune functions, is an antioxidant, and [is] an important cardiovascular nutrient,” Levin said. “It is not good to lower one’s coQ10 levels by half!”

Moreover, said Levin, statins increase the tendency of muscle tissues to break down. “Combined with inactivity or certain drugs, this can stimulate muscle wasting,” he said. “Muscle is where a good deal of calories are burned, so a loss of muscle could affect mobility and energy production, potentially adding to obesity problems. These muscle changes occurred in patients and persisted for years after treatment was discontinued, as shown by muscle biopsies, even if no obvious muscle problems were observed by the patients.”

And the last word on the subject may not have been spoken. Predicted Dr. Frank King, Jr. president of King Bio Natural Medicine (Asheville, NC), “Once the appropriate studies are finished, these drugs, along with hypertensives, will hit the fan bigger than the COX-2 inhibitors.”

Also looking toward the future, Levin said that of the 20 million Americans who will be “targeted” for statin drug prescriptions under the new NCEP guidelines, “Some of these will want to try natural methods first. Others will rebel at the side effects of the drugs and experiment with alternative products.”

King and Levin both saw opportunity for natural products in the fallout from drug safety concerns, with King projecting that sales of his company’s cholesterol-related homeopathic remedies will double in 2005. “The reports of deaths from drugs will always overshadow the trumped-up studies and news reports blasting dietary supplements,” said Levin. “Vioxx knocked vitamin E off the media’s radar screens pretty rapidly, though we still see ignorant reporters citing that [Johns Hopkins] vitamin E analysis as if it were true. But the comparable safety of supplements means that open-minded people will want to at least try natural therapies before signing in to a lifetime of drug therapies. Meanwhile, the studies on natural products will continue to build our credibility.”

Those studies keep coming in, with at least four major findings published in the past few months, plus a heart-health claim on walnuts authorized by FDA. They join a raft of earlier findings that link natural products—branded and otherwise—to healthy cholesterol levels.

"Blur of Products"

With so many natural alternatives to cholesterol drugs available, it can be hard to keep track. “As with any other category, the blur of products as they cascade over several shelves means that the retailer needs to have a good sense of what works and what they want to recommend to their customers,” Levin said. “Really, each person needs a protocol that would include antioxidants, fiber, vitamins, herbs, and oils. The pre-mixed cholesterol support formulas are a good starting place.”

To help retailers get a sense of “what works,” here is an alphabetical discussion of several nutrients that have demonstrated benefits in serum cholesterol levels. They include the following:

Barley may help lower cholesterol, according to a report in the American Journal of Clinical Nutrition (2004, vol.80, no.5: 1185-1193). Twenty-five adults with mild hypercholesterolemia consumed a controlled diet low in total fat, saturated fat, and cholesterol for 19 weeks. They then added whole-grain products containing barley to their diets that contained low (0 g), medium (3 g), or high (6 g) amount of beta-glucan per day for five weeks. Total cholesterol was reduced by 4 percent 9 percent, and 10 percent, respectively. The diet with the highest amount of beta-glucan led to a decrease in LDL cholesterol of 17 percent.

Chromium. There’s evidence, Levin said, that chromium in doses of 500 mg a day may decrease levels of low-density lipoprotein (LDL, the so-called “bad” cholesterol) and total cholesterol while raising levels of high-density lipoprotein (HDL, or “good” cholesterol). At the annual meeting of the American College of Nutrition last October, a poster presentation on the safety of Benicia, CA-based InterHealth Nutraceuticals’ ChromeMate niacin-bound chromium won first prize; among other things, the presentation cited chromium’s role in maintaining healthy blood lipid levels.

Fatty Acids. The latest in a long line of studies demonstrating the benefits of fatty acids in heart health is a study published in The International Journal of Clinical Pharmacology and Therapeutics in December 2004. It showed that docosahexaenoic acid (DHA), an omega-3 fatty acid, can restore normal blood vessel function in children with inherited high cholesterol. The study, which used Martek DHA produced from microalgae, concluded that restoration of normal blood vessel function has the “potential for preventing the progression of early coronary heart disease in high-risk children.”

“The evidence continues to accumulate on the cardiovascular benefits of DHA for people of all ages,” said Henry “Pete” Linsert, Jr., chairman and CEO of Martek Biosciences, an ingredient supplier based in Columbia, MD. “This study clearly indicates that DHA played an important role in healthy blood vessel function in the children in this study.”

On the Omega-Research.com Website maintained by fish oil manufacturer Nordic Naturals (Watsonville, CA) can be found summaries of several earlier studies linking omega-3 fatty acids to maintaining healthy blood lipid levels, as well as related benefits such as elasticity of the arteries. In a 2003 study published in the American Journal of Clinical Nutrition, it was found that women receiving a mixture of 4 g eicosapentaenoic acid (EPA) and DHA along with 2 g of gamma-linolenic acid (GLA) had lower levels of LDL cholesterol after 28 days compared to those who received either the EPA/DHA supplements without DHA, EPA/DHA with a smaller dose of GLA, or GLA alone.

Flax is another source of omega-3s, and Arkopharma/Health From The Sun (Bedford, MA) offers FiProFLAX in a variety of forms. Marketing director Hugues P. Mas said the flax is “QAI [Quality Assurance International] certified organic and guaranteed GMO [genetically modified organism]-free.” On its Website, the company offers a cholesterol quiz geared to consumers, discussing the importance of omega-3s as well as other nutrients.

Garlic. Adding to an already considerable body of research demonstrating that garlic can lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol, researchers at UCLA in 2003 reported that Kyolic aged garlic extract reduced or inhibited plaque formation in the arteries of 19 cardiac patients taking statin drugs.

Lead researcher Matthew Budoff, Ph.D. commented at the time that the study “suggests that aged garlic extract may be a useful and beneficial dietary addition for the people who have high cardiovascular risk or who have undergone heart surgery.” Budoff has since presented several trade show seminars sponsored by Los Angeles-based Wakunaga of America, the makers of Kyolic.

Guggul. In use for centuries as a component of Ayurvedic medicine, guggul—a gummy resin tapped from the Commiphora mukul tree, which is native to India—has been studied since the early 1960s for its hypolidemic (blood-lipid lowering) properties. Sabinsa Corp. (Piscataway, NJ), an ingredient supplier which produces a standardized extract under the brand name Gugulipid, says the studies on guggul indicate that its hypolipidemic activity can be attributed to more than one mechanism of action.

Among the possible mechanisms are: inhibition of cholesterol biosynthesis, enhancing the rate of excretion of cholesterol, promoting rapid degradation of cholesterol, thyroid stimulation, alteration of biogenic amines, and “high affinity binding and anion exchange.”

Homeopathy. “Homeopathy activates the body’s own control system to work properly,” said King. “This is the safest and most curative approach to take.

“Forcing the body into biochemical change even naturally doesn’t actually have the curative action of homeopathy,” King continued. “Homeopathy can even correct the genetic predispositions to disease we may have inherited from as deep as a thousand years into our family chain.” King Bio makes Artery/Cholesterol/BP, a homeopathic formula intended to help tone heart muscles and blood vessels.

Low glycemic index foods. In a study published in the February issue of the American Journal of Clinical Nutrition, researchers found that high glycemic load is negatively correlated to serum levels of HDL cholesterol. Assessing the relationship between blood levels of lipids and diet in a test population of 32 healthy males and females ages 11 to 25, the researchers found that glycemic load accounted for 21.1 percent of the variation in HDL cholesterol. They concluded that glycemic load appears to be an important independent predictor of HDL cholesterol in youth and noted that dietary restrictions without attention to glycemic load could unfavorably influence blood lipids.

Medicinal Mushrooms. Although its product SX-Fraction is intended primarily to address high blood sugar, Maitake Products, Inc. (MPI, Ridgefield Park, NJ) found in a clinical study that LDL cholesterol in diabetic patients declined modestly (from 142 mg/dl to 133 mg/dl) over a two-month period. Those taking SX-Fraction also lost about 7 lbs. in the same time period.

“The more impressive lowering of cholesterol, however, comes from the dietary fiber that is found in all medicinal mushrooms,” said Ellen Shnidman, manager of scientific affairs at MPI. She cited animal studies which documented the cholesterol-lowering properties of four different mushrooms: maitake, shiitake, agaricus, and enokitake.

For example, a study reported in the September 1996 issue of Alternative Therapies showed “a 44 percent reduction in total cholesterol in rats consuming maitake mushroom in their diet,” said Shnidman. “This cholesterol reduction is accompanied by weight loss, relative to rats eating a similar high-choelsterol diet without mushrooms. Apparently, cholesterol is excreted by the rats in sufficient quantity to aid in weight loss.”

Oat bran. A 2004 consumer study conducted by the Natural Marketing Institute (NMI, Harleysville, PA) for Nurture, Inc. (Devon, PA), which produces the ingredient OatVantage, found that 63 percent of consumers managing their cholesterol levels prefer oat-based ingredients.

Oat bran is the subject of a health claim authorized by FDA in 1999, and NMI research found that 69 percent of respondents preferred the FDA-permitted health claim, “Helps Lower Cholesterol,” over the model structure-function claim, “Helps Maintain Healthy Cholesterol Levels.” “This is significant for food, beverage, and dietary supplement manufacturers who want to increase sales by using a more consumer-desired claim on the product label,” said Griff Parker, Nurture CEO.

Plant sterols. Also the subject of an FDA-approved claim for heart health, plant sterols (structurally similar to cholesterol in humans) can block the absorption of cholesterol, according to a number of studies. In an “Ask the Doctor” publication (available online at www.atdonline.org), Decker Weiss, N.M.D. noted that sterols enter the same receptor sites that cholesterol enters on its way to the bloodstream. “The cholesterol, being blocked from absorption, remains in our intestines where it is eventually excreted,” Weiss wrote. General Mills has just introduced Yoplait Healthy Heart, a yogurt high in plant sterols.

policosanol. A mixture of fatty alcohols derived from sugar cane or beeswax, policosanol has been favorably compared in clinical studies to several types of prescription drugs for managing cholesterol. On its own, policosanol was found in a 1999 study to reduce LDL cholesterol while raising levels of HDL cholesterol.

Probiotics. “Several studies have indicated that consumption of certain cultured dairy products resulted in reduction of serum cholesterol, as well as triglycerides,” wrote Dr. S.K. Dash, president of probiotic manufacturer UAS Laboratories (Eden Prairie, MN), in his Consumer Guide to Probiotics. Among other studies, Dash cited two controlled clinical studies from the VA Medical Center at the University of Kentucky.

“In the first study, fermented milk containing [Lactobacillus] acidophilus was accompanied by a 2.4 percent reduction of serum cholesterol concentration,” he wrote. “In the second study, a different L. acidophilus strain reduced serum cholesterol concentration by 3.2 percent. Since every 1 percent reduction in serum cholesterol concentration is associated with an estimated 2 to 3 percent reduction in risk for coronary heart disease [CHD], regular intake of fermented milk containing an appropriate strain of L. acidophilus has the potential of reducing risk for [CHD] by 6 to 10 percent.”

Dash said his company’s DDS Probiotics contain DDS-1 L. acidophilus, “which has been researched and demonstrated to show cholesterol-lowering effect.”

Psyllium. “Internal cleansing is very important” in maintaining healthy cholesterol levels, “especially if you do it with a lot of fiber,” said Sunil Kohli, vice president of Chino, CA-based Health Plus, Inc. The cholesterol-managing ability of fiber in general and psyllium in particular is “very well-established,” he said.

However, Kohli said, “It will probably do you no good if it’s random. It should be done on a regular basis, and it should be supervised. Consulting the doctor or pharmacist is important.”

Soy. The protein in soy “has evidence of lowering total cholesterol and LDL cholesterol, based on reviews of studies using over 20 g of soy protein per day,” said Levin. “Soy isoflavones are considered only partly responsible for this effect.”

Sytrinol. A patented proprietary formula derived from natural citrus and palm fruit extracts and containing citrus polymethoxylated flavones and palm tocotrienols, Sytrinol has been shown in clinical trials to improve total cholesterol, LDL cholesterol, and triglycerides by up to 30 percent, 27 percent, and 33 percent, respectively. Having just wrapped up Phase III of a long-term trial of Sytrinol, Chicago-based SourceOne Global Partners, which owns the exclusive worldwide license for intellectual property associated with the ingredient, is commencing a study that combines Sytrinol with plant sterols.

Tocotrienols. On its Website discussing the science and benefits of tocotrienols (www.tocotrienol.org), ingredient supplier Carotech Inc. (Edison, NJ) identifies several benefits for blood lipid levels. Tocotrienols, according to the Website, have been shown to “inhibit cholesterol production in the liver, thereby lowering total blood cholesterol;” “[suppress] hepatic HMG-CoA reductase activity [and result in] the lowering of LDL cholesterol levels;” and “inhibit cholesterogenesis by suppressing HMG-CoA reductase.”

New Weapons

There are also nutrients that are emerging as potential weapons in the fight against cholesterol. Levin cited rice bran oil, resveratrol, pantethine, l-carnitine, and niacin as showing promise.

With all of this, Levin said, it’s important for retailers to remember that “they are not allowed to discuss diseases and remedies unless there is an approved FDA health claim allowed on the label, as with soy protein and plant sterols. What is allowed are structure-function claims such as ‘cholesterol support,’ ‘promoting normal, healthy circulation,’ ‘homocysteine regulators,’ etc.”

Supplementation is only one tool for managing cholesterol levels, manufacturers pointed out. “Besides nutrition, lifestyle is a key to controlling cholesterol,” Levin said. “Eating a variety of antioxidant-rich foods will prevent the liver from churning out cholesterol as a ‘cheap’ antioxidant. The body uses oxidized cholesterol to patch leaky and damaged blood vessels, so the ability to build healthy collagen is a must, using nutrients like vitamin C, Pycnogenol, rutin, hyaluronic acid, and MSM.

“Don’t forget exercise and stress reduction,” he added. “Stress results in high cortisol levels—usually accompanied by poor blood lipid levels—and a lack of good sleep to produce unhealthy people.” VR

Vitamin Retailer Magazine, Inc., 431 Cranbury Road, East Brunswick, NJ 08816 //www.oprmagazine.com/

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Date: May 09, 2005 11:35 AM
Author: Darrell Miller (dm@vitanetonline.com)

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