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Prepping basics: 5 Effective natural remedies for ulcers Darrell Miller 4/25/19
Experts warn there is a new variant to metabolic problems: Type 3c diabetes is being misdiagnosed, which is why many aren't responding to treatment Darrell Miller 11/25/17
California Could Become a Sanctuary State — for Marijuana Darrell Miller 4/7/17
Caffeine Found to Reduce Age-Related Inflammation Darrell Miller 1/24/17
Sunlight offers surprise benefit: It energizes infection fighting T cells Darrell Miller 1/2/17
Signs of Low Blood Sugar Darrell Miller 11/8/13
Support the Adrenal Glands with Natural Vitamins and Feel the Difference Darrell Miller 10/5/11
What Is the Life Span Of Human Cells And How Do Antioxidants Help? Darrell Miller 8/25/11
Can Herbs and Prunes Help with Constipation Darrell Miller 3/30/11
Best Digestive Supplements Darrell Miller 12/8/10
Curcumin Is "The All In One Solution" - Said by Doctors In India! Darrell Miller 1/29/10
L-Carnitine Darrell Miller 5/7/09
Grape Fruit Pectin Fiber Darrell Miller 10/21/08
Garlic Darrell Miller 9/1/08
Maitake Mushroom Darrell Miller 5/24/08
What can we do about it? Darrell Miller 6/26/07
Vitamin D May Show Benefits Against Breast and Colorectal Cancer Darrell Miller 2/27/07
Remifemin symptomatic relief, scientifically supported* Darrell Miller 8/26/06
Your Cells Supercharge Your Cells Darrell Miller 12/20/05
The Role of Naturally Occurring Progesterone in the Body Darrell Miller 7/25/05
Anti-Aging Nutrients Darrell Miller 6/18/05
Gotta Habit Darrell Miller 6/14/05
Move it and Lose it! Burn off body fat! Darrell Miller 6/14/05
Nutrients for Longevity Darrell Miller 6/10/05
Higher Mind - Smart Nutrients for the Performance of a Lifetime... Darrell Miller 6/2/05




Prepping basics: 5 Effective natural remedies for ulcers
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Date: April 25, 2019 04:41 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Prepping basics: 5 Effective natural remedies for ulcers





Peptic ulcers occur when an individual's digestive juices cause damage to the walls of the intestines or stomach. Usually, peptic ulcers are caused by H. pylori, a bacteria that causes inflammation in the digestive tract. Burning pain is the most commonly known symptom of a peptic ulcer. Other symptoms include belching, heartburn, bloating, nausea, and weight loss. Aloe vera taken orally is one natural remedy for ulcers. Cabbage juice, chamomile, and honey also all fight peptic ulcers without the negative side effects of medication. While ulcers are usually just irritating, they will become debilitating if left untreated.

Key Takeaways:

  • Although ulcers can occur anywhere on the body, they are especially common along the digestive tract.
  • Peptic ulcers occur in the stomach and intestines as a result of digestive juices damaging the lining.
  • Aloe vera, which is used topically for burns and infections, can be used internally to treat ulcers.

"Ulcers are common, and how they appear and their corresponding symptoms depend on their cause and where they develop on your body."

Read more: https://www.naturalnews.com/2019-03-06-natural-remedies-for-ulcers.html

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Experts warn there is a new variant to metabolic problems: Type 3c diabetes is being misdiagnosed, which is why many aren't responding to treatment
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Date: November 25, 2017 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Experts warn there is a new variant to metabolic problems: Type 3c diabetes is being misdiagnosed, which is why many aren't responding to treatment





Type 3c diabetes is frequently being misdiagnosed as type 2 diabetes. This serious misdiagnosis is causing many patient to fall critically ill. As the doctor's treatment plan for type 2 diabetes isn't the right treatment path for type 3c diabetes. Type 3c diabetes is also called pancreatogenic diabetes. The inflammation and excessive tissue growth of the pancreas contribute to the onset of this serious condition. The wrong diagnosis can cause adverse medical conditions, both short and long term, for the patient involved. It is of vital importance that the medical profession inform themselves about this condition to avoid serious health risks from misdiagnosis to their patients.

Key Takeaways:

  • Type 3c Diabetes, or pancreatogenic diabetes,is a newer type of diabetes.
  • This type has been shown to have problems if misdiagnosed and getting the wrong treatment.
  • The overall problem is treatment and the ability to take care of these people properly

"Our research shows that the majority of people with type 3c diabetes are being misdiagnosed with type 2 diabetes, putting both their short and long term health at risk"

Read more: https://www.naturalnews.com/2017-11-21-experts-warn-there-is-a-new-variant-to-metabolic-problems-type-3c-diabetes-is-being-misdiagnosed-which-is-why-many-arent-responding-to-treatment.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5415)


California Could Become a Sanctuary State — for Marijuana
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Date: April 07, 2017 11:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: California Could Become a Sanctuary State — for Marijuana





With a new bill proposed in California, the state could soon go against the federal marijuana prohibition. The bill would require a court order to take actions against a person suspected of marijuana use. This also prohibits law enforcement from responding to federal request for personal information or providing information on individuals with a license for marijuana. In addition, the bill also prohibits the transfer of an individual to federal law enforcement for anything marijuana related. The bill has been met with some opposition, especially from law enforcement groups, citing it would limit the effectiveness of their job.

Key Takeaways:

  • California's Assembly Bill 1578, if passed, would stop cooperation between state and federal law enforcement, when it comes to the state's marijuana policy.
  • The law is also aimed at protecting legal marijuana businesses as long as they operate within the state's laws and regulations.
  • Several states have approved marijuana use for at least medicinal purposes. Federal legislation has yet to be passed.

"The proposed law is essentially an attempt to strengthen California’s already existing laws, which conflict with federal policy on the plant."

Read more: http://www.healthnutnews.com/california-become-sanctuary-state-marijuana/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4371)


Caffeine Found to Reduce Age-Related Inflammation
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Date: January 24, 2017 12:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Caffeine Found to Reduce Age-Related Inflammation





A study has published that caffeine could reduce cardiovascular disease risk factors. So caffeine may actually be more beneficial to you then you thought. In their studies researchers found that the metabolites boosted activity in one of the inflammatory gene clusters. That, in turn, caused the immune cells to produce more IL-1ß. When injected into mice, the substances triggered widespread inflammation and hypertension.

Key Takeaways:

  • Caffeine may help reduce the type of inflammation that's linked to cardiovascular disease risk factors,
  • David Furman, Ph.D., of the Stanford University School of Medicine in California, and colleagues studied data on healthy participants ages 20 to 30 and another group older than 60.
  • "Our results show an overall up-regulation of specific inflammasome genes in older humans and identify two distinct immune states corresponding to chronically inflamed individuals with dysregulated nucleotide metabolism, high levels of oxidative stress,

"Caffeine may help reduce the type of inflammation that's linked to cardiovascular disease risk factors, according to a study published online Jan. 16 in Nature Medicine."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//www.doctorslounge.com/index.php/news/pb/69298&ct=ga&cd=CAIyGmZmMDFkMTU2YWMzMmQ5OTU6Y29tOmVuOlVT&usg=AFQjCNFDdT9sZaJZ1owK89gxvIfdRbR7BQ

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3823)


Sunlight offers surprise benefit: It energizes infection fighting T cells
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Date: January 02, 2017 03:19 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Sunlight offers surprise benefit: It energizes infection fighting T cells





Have you ever been at work and thought about how nice it must be outside? According to researchers, the sunlight may be even more beneficial for us. According to their research, sunlight increases the movement of T cells. The increased movement in cells can help activate key immune cells by increasing their movement.

Key Takeaways:

  • Georgetown University Medical Center researchers have found that sunlight, through a mechanism separate than vitamin D production, energizes T cells that play a central role in human immunity.
  • They specifically found that low levels of blue light, found in sun rays, makes T cells move faster, marking the first reported human cell responding to sunlight by speeding its pace.
  • Production of vitamin D required UV light can promote skin cancer and melanoma. Blue light from the sun, as well as from special lamps, is safer.

"Sunlight allows us to make vitamin D, credited with healthier living, but a surprise research finding could reveal another powerful benefit of getting some sun."



Reference:

https://www.sciencedaily.com/releases/2016/12/161220094633.htm

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3732)


Signs of Low Blood Sugar
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Date: November 08, 2013 09:36 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Signs of Low Blood Sugar

Types of Low Blood Sugar

blood sugarIf you live with or know a type 1 or type 2 diabetic, then you should be aware of the signs of low blood sugar so that you are in a position to help if and when an emergency arises.

Diabetes

Diabetes is a chronic illness that affects nearly 8 percent of the United States population, according to the American Diabetes Association. The disease is characterized by the absence of insulin in the bloodstream (type 1 diabetes) or the body's inability to utilize insulin effectively (type 2 diabetes).

Since insulin is the mechanism that allows glucose in the bloodstream, known as blood sugar, to provide food for the brain and energy to the body's organs and cells, diabetics must inject insulin or take other oral medications to counteract any insulin deficiency. All diabetics must also follow a daily regimen that includes a heart-healthy diet and plenty of physical activity to help regulate blood sugar levels.

About Blood Sugar

Normal blood sugar levels are 70 mg/dl to 120 mg/dl. If a diabetic consumes too many carbohydrates or doesn't take enough insulin, blood sugar levels can run high, resulting in a condition known as hyperglycemia. Blood sugar levels below 70 mg/dl is considered hypoglycemia, a life-threatening condition. Fortunately, there are several initial signs of low blood sugar that help the diabetic and those around them know that a medical situation is arising.

Causes of Low Blood Sugar

Some causes of low blood sugar are under a diabetic's control, including: insufficient carbohydrate consumption. Consuming alcoholic beverages. Prolonged strenuous  physical activity. Other causes of hypoglycemia can catch a diabetic by surprise: Mental or emotional stressSevere or prolonged illness

Signs and Symptoms of Hypoglycemia

Most diabetics are able to identify the signs of low blood sugar fairly quickly and treat it before the condition becomes serious -- but not always. If someone's blood sugar levels normally run between 100 mg/dl and 120 mg/dl they might feel the onset of low blood sugar symptoms when they near the 70 mg/dl mark. Diabetics whose blood sugar levels are usually on the lower end of the spectrum, like in the 70 mg/dl to 80 mg/dl range, may not begin to feel symptoms of hypoglycemia until their blood sugar levels are already dangerously low.

The onset of symptoms usually includes:

  • Shakiness or trembling. Hunger dizziness
  • If not treated quickly, signs of low blood sugar can develop into:
  • Headache extreme sweating. A feeling of being disoriented. Denial of any blood sugar level problems. Extreme anger or giddiness
  • If hypoglycemia is not treated at this point or is not responding to treatment, the person can quickly become unconscious, suffer seizures or even fall into a coma which can lead to brain damage or even death.
  • Not everyone will develop all of these symptoms and some people may develop signs that are not on this list. When with a diabetic, just be on the lookout for behavior that is not normal for them. They may resist checking their blood sugar levels. If they do, on the side of caution and continue on with treatment.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2882)


Support the Adrenal Glands with Natural Vitamins and Feel the Difference
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Date: October 05, 2011 03:50 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Support the Adrenal Glands with Natural Vitamins and Feel the Difference

Your Adrenal Glands, Energy Levels, And How You feel

Our body is a very complex system that needs to be well taken care of through adequate intake of essential vitamins and minerals. Living healthy and right will allow you to reap and experience a better and more comfortable life in the future.

The adrenal glands are one of the most important glands in the body. It can be found on top of your kidneys; however, these two glands that you have in your body are actually different from one another. The center of the gland also known as the adrenaline manufactures epinephrine and is governed by the autonomic nervous system. These vital glands perform special functions that are very essential for life and health. Any alteration in condition would surely have corresponding effects in the body.

For us to keep our adrenal glands healthy, it is very necessary to consume foods that are rich with the following:

Vitamin B-Complex

B vitamins can help restore the adrenal glands when they are over worked from the stresses of life.

Vitamin C

It is inevitable that vitamin C is one of the most useful vitamins for the body because of its capacity to strengthen the immune system hence, keeping you away from the threats of diseases and body disequilibrium. To be more specific, vitamin C is very crucial for adrenal function. The highest concentrations of vitamin C can be found in the brain tissues and in the adrenal glands because the secretion of the vitamin is at its peak during stress. To help your immune function, it is advisable that you will take 500 to 1000 mg of the said vitamin per day.

Pantothenic acid

For optimal adrenal function, it is advisable to take about 100 to 150 mg of pantothenic acid daily because this vitamin B is noted to support and enhance adrenal function as well as correct adrenal deficiency.

Licorice

Has the innate capacity to prevent adrenal hormones breakdown therefore maintaining optimal levels. Another vital function of licorice is its power to cure indigestion.

Chromium

If you want to lessen the discomforts that you will feel during low blood sugar episodes, it is advisable for you to consume and take natural remedies and supplementation that are rich with chromium. The Adrenal Stress End has enough chromium content which is highly beneficial for the success of an enzymatic therapy. Experts would recommend taking one to two capsules per day for you to grasp its full effects.

To sum up everything, it is very important to take and engage in measures that could help us achieve optimum level of wellness because if not we will surely suffer from the consequences of being sick brought about by a disequilibrium in the body. Since we all know how important our adrenal glands are and the distinct function that it do for the body, we should do our very best to keep it healthy and well functioning. Vitamin C, licorice, Pantothenic acid, and chromium are just few of the important elements that you should provide your adrenal glands. Taking these would make you feel better and secured.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2484)


What Is the Life Span Of Human Cells And How Do Antioxidants Help?
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Date: August 25, 2011 10:38 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Is the Life Span Of Human Cells And How Do Antioxidants Help?

 Antioxidant Multi-Plex 60ctThe human body is composed of many different cells. These cells have varying functions as well as life span. The human cells, in general, are very complex. Some cells may last only within a day while others may be for life. Like for example, one blood component known as neutrophil lasts only within 24 hours. On the other hand, another blood component which is red blood cell has a life span of 120 days. One human cell which lasts for a lifetime is the stem cell. Stem cells are undifferentiated cells which are the source of blood cells. They supply the body throughout life both with red and white blood cells. Here is a brief outline of some cells of the human body with their corresponding life spans.

1. Granulocytes such as eosinophils, basophils and neutrophils – half day to 3 days

2. Stomach and colon lining cells – 2 to 4 days

3. Sperm cells – 2 to 3 days

4. Epithelial cells of the small intestines – 5 to 7 days

5. Platelets – 10 days

6. Skin epidermal cells – 14 to 28 days

7. Lymphocytes, macrophages and endothelial cells – 2 months to a year, but may vary

8. Pancreatic cells – a year or more

9. Bone cells – 25 to 30 years

As shown above, these human cells have an expected time of death. However, if the body is exposed to harmful toxins, their life span significantly decreases. As we know for a fact, the body undergoes many biological reactions almost every second. The reaction is called oxidation process which is essential to the body. However, such reaction has harmful by – products in the form of free radicals. Free radicals can cause the body significant damage. Free radicals can cause destruction and death of the healthy cells of the body and also affect the body’s cellular division. This kind of chemicals can potentially tamper DNA replication during cell division. Once cellular division is tampered, abnormal growths would likely happen. Aside from the naturally occurring free radicals, external stressors can also cause damage to the cells of the body. Some of these include pollutants, harmful chemicals and irritants. These harmful chemicals can potentially lead to the development of certain disease conditions such as heart diseases, stroke and cancer.

Fortunately, there are many antioxidants which can greatly help in the prevention of free radical damage by protecting the cells of the body. Antioxidants are molecules which can effectively prevent the oxidation of other molecules. There are many natural antioxidants found among plants and animals. Some common antioxidants are glutathione, vitamin C and vitamin E. Other nutrients which have antioxidative property include beta – carotene, lutein, lycopene, vitamin A and selenium. Fruits and vegetables are great sources of antioxidants. Nuts, grains, meat, poultry products and fish are also good sources of such cell – protecting chemicals. In addition, dietary supplements of antioxidants are also widely available in the market. However, health experts highly suggest that before supplementation of antioxidants, medical evaluation must be done first to be completely safe.

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Can Herbs and Prunes Help with Constipation
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Date: March 30, 2011 02:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can Herbs and Prunes Help with Constipation

Herbs and Prunes as a natural laxative

Herbs and Prunes must be the best digestive formula out there. It contains a select combination of herbs whose laxative properties are tried and tested for decades, namely: senna leaf, Chinese rhubarb root, Chinese asparagus, beet leaf, buckthorn bark, cabbage leaf, cascara sagrada bark, celery leaf, cranberry fruit, Culver’s root, parsley leaf, spinach leaf, and prune fruit. In addition to their long-standing association with alternative medicine, medical research has pointed to their active ingredients that are purgative in nature. These herbs not only relieve digestive problems such as constipation and indigestion but also cleanse the gastrointestinal tract, effectively disposing of toxins.

Induces Bowel Movement

There are several factors that may give rise to constipation, but in most cases it results from withholding bowel movement far longer than what is considered normal. In general, a healthy individual is expected to discharge fecal matter from the bowels at least once a day although it may vary from person to person. The rectum sends messages to the brain every time the final phase of digestion is about to take place, and not responding to these messages leads to reversing the direction of the feces, which are temporarily stored in the colon. However, the colon is not able to reduce the pressure the feces produce for long periods of time, leading to constipation. The unique formulation of Herbs and Prunes relaxes the intestinal walls and softens the stools, making it much easier to evacuate the bowels.

Alleviates Abdominal Pains

The phytochemicals that are considered the active ingredients of Herbs and Prunes include anthraquinones, such as senna glycosides, sorbitol, and isatin, such as dihydrophenylisatin, among others. These organic compounds are reputed for their laxative properties that soothe the muscles tissues within the intestinal walls and influence the releases of chemicals that sensitive the digestive tract to pain. Irregular bowel movement causes what we refer to as stomach pains, and more often than not the foods that we eat influences regularity. A balanced diet is named so because it promotes digestion as well as gives us the nutrients our body needs in right amounts. Herbs and Prunes works on the principle of supplying our body with all-natural, plant-based dietary fiber and phytochemicals that restores normal digestion.

Detoxifies the Digestive Tract

Herbs and Prunes comprises a significant fraction of both soluble and insoluble fiber that are guaranteed to wash away toxins when ingested with ample amounts of liquids. As diet significantly influences human health, it is not surprising that the digestive system may be rendered susceptible to unhealthy foods. The alimentary canal is our first line of defense against toxins that the foods we eat produce. Plant-based foods that contain fiber remove by-products of digestion that otherwise accumulate in the bowels. In conjunction with phytochemicals, fiber is known to reach parts of the alimentary canal that play host to harmful microorganisms, the reason why plant-derived medications are often the cure to many diseases of the digestive system.

Herbs and Prunes

It is always recommended to keep a herbs and prunes formula on hand when irregularity hits. Grab yourself a bottle today!

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2263)


Best Digestive Supplements
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Date: December 08, 2010 05:30 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Best Digestive Supplements

When you need to decide on a digestive enzyme supplement, it's important to know that not all of them are created equally. Some may contain more of one ingredient than the other and some might only contain one of three groups of enzymes. A leading digestive enzyme complex was studied to see what ingredients will provide your digestive system with the best possible support. Following is the ingredients of possibly the best digestive supplement you can get your hands on. digestive tract

The first ingredient found in this complex is protease. This enzyme breaks down long protein chains at different levels of your stomach's pH level.

Amylase is another enzyme found in this complex. It breaks down large carbs like starches into disaccharides and glucose for your body's energy levels.

Lipase, another ingredient of the best digestive supplement, breaks down the fats you consume into fatty acids and glycerol. SOURCE NATURALS - Essential Enzymes 500 mg Vegetarian 60 caps Cerecalase, another great ingredient, is a blend of enzymes which breaks down the cell wall bonds of nutrients such as phytate and hemicelluloses.

Glucoamylase breaks down maltose into glucose, malt diastase enhances the breakdown of starch and peptidase hydrolyzes protein molecules into amino acids.

Bromelain

More ingredients include bromelain - extracted from pineapple stems, papain extracted from papaya; another enzyme which helps to digest proteins and a last ingredient, cellulase, which breaks down the cellulose and glucose found in fiber. Solaray - Bromelain 60ct 500mg You might wonder whether these enzymes are being destroyed by your stomach juices, but most of the best digestive supplements' ingredients are processed in such a manner that they can withstand the extreme conditions in your stomach. This myth has been disproven countless of times, so it's not a waste of your money to invest in the best digestive supplements.

When you've taken the best digestive supplements, you can expect to have more energy and have better digestion and bowel movements. It is normal for some people to experience detoxification in the beginning stages of taking these supplements. This might feel uncomfortable but it is a good sign that your body is responding positively to the enzymes. Upping your enzyme intake and drinking a lot of water can help you through the beginning process.

When looking for the best digestive supplement, you should look at the enzyme activity rather than the ingredients. The most important thing is to look out for supplements that are acid stable and able to be active in a broad range of pH levels. Steer clear of any ingredients you might be allergic to, like papain or bromelain. Look for what experts call a broad range digestive supplement. The more enzymes it contains, the wider the range of nutrients it will make your body able to digest. When in doubt, speak to your doctor or pharmacist first. If you have specific digestive problems you should have that looked into before trying such a common remedy.

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Curcumin Is "The All In One Solution" - Said by Doctors In India!
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Date: January 29, 2010 09:23 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Curcumin Is "The All In One Solution" - Said by Doctors In India!

curamin root and powderDoctors in India call it the “all in one solution. Their "all in one solution" is curcumin. Why would medical professionals describe curcumin with such a powerful statement? Could it really be so powerful that it truly is the “all in one solution”?

I have researched herbs and nutrition for 40 years. I think I have pretty good knowledge of many of the top medicinal plants in the world. However, several years ago I began to see a number of studies on curcumin from different scientific institutions in various parts of the world. In all, over 2,000 studies have been conducted on curcumin over the last several years, and as many as a dozen new studies every month. I began to wonder - why has this plant intrigued so many scientists? This large amount of research is a clue that scientists are seeing a tremendous medicinal benefit of curcumin. This really piqued my curiosity, and while I do not have a specific technical background, I have a passion for research and development of high quality medicinal products. I began corresponding with scientists around the world to inquire as to what they were discovering and why there was this huge influx of scientific research. Eventually, a group of scientists invited me to a conference in India on curcumin. What I discovered was truly amazing. After 40 years in the health food industry and alternative medicine, I never thought I would have the opportunity to see a plant with such medicinal benefits.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2122)


L-Carnitine
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Date: May 07, 2009 05:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: L-Carnitine

L-carnitine is amino acid essential for the metabolism of fats into a form of energy necessary for extended aerobic activity. Originally discovered in Russia, and Germany a year later, the structural formulation of carnitine, as it is correctly known, was determined in 1927, although it is physiological and biochemical activity was not understood until the 1960s.

The amino acid is biosynthesized in the liver and kidneys from lysine and methionine. The vitamins niacin, B6, C and iron are essential for this reaction to take place. However, the supply of L-carnitine has to be supplemented by the diet, good sources being dairy products, red meat, nuts and seeds, pulses and fruits such as apricots, bananas and avocado. Most of the L-carnitine supply of the body is stored within the muscle tissue. However, it is not unusual for conditions to arise making it difficult for the body to obtain all the carnitine required.

L-carnitine enables fatty acids to be transported into the mitochondria, where cell metabolism occurs. The biochemistry is discussed below, although in simple terms the amino acid allows body fats, in the form of triglycerides, to be made more readily available for the generation of energy required for extended exertion. In this way, body fats can be used for energy and the supplies of glycogen stored by the liver can be retained for emergency use.

By providing the energy for endurance and stamina in this way, carnitine makes use of an otherwise unavailable energy source, and has the added benefit of reducing body fat stores and reducing strain on the heart.

Although there is generally a plentiful supply of L-carnitine available in a healthy diet, supplementation can ensure that a deficiency does not occur. Supplements are available in the form of L-carnitine or its acetylated derivative, acetyl L-carnitine.

In order for fatty acids to be used in the production of energy, their long-chain acetyl groups have to get inside the mitochondria where they are oxidized to the acetate to be used for the production of energy via the Citric Acid or Krebs cycle.

In order for the biochemistry to take place, fatty acids must be rendered suitable for binding to the carnitine molecule. The chemical grouping with a good affinity for L-carnitine is the acetyl or acetyl group, available in the molecule acetyl coenzyme A (CoA). The free fatty acid, therefore, is attached to coenzyme-A by means of a thioester bond, catalyzed by means of the enzyme fatty acetyl-CoA synthetase. The reaction is then completed by means of in organic pyrophosphatase.

In this way, the fatty acid in the form of an acetyL-carnitine derivative can be transported through the mitochondrial wall. This transportation takes place by means of several steps. These are:

1. As explained, the acetyl-CoA is attached to L-carnitine by means of the enzyme carnitine acetyltransferase I. This enzyme is conveniently located on the outer mitochondrial membrane.

2. The enzyme carnitine-acetylcarnitine translocase helps the acetyL-carnitine through the membrane.

3. Another enzyme, carnitine acetyltransferase II, located on the inner mitochondrial membrane, converts the acetyL-carnitine to acetyl-CoA, liberating the carnitine which returns to the muscle mass.

L-carnitine is the only known substance that allows fatty acids to cross the mitochondrial membrane, and therefore deficiencies must be avoided.

Another way in which carnitine is used in energy production is in the Krebs cycle itself. Part of this cycle involves the conversion of guanine diphosphate to the higher energy form guanine triphosphate. In this way energy can be stored in much the same way as it is in the conversion of ADP to ATP. Succinyl CoA is involved in this conversion, and one of the by-products of it is a corresponding succinate, that is then converted to a fumarate by the action of L-carnitine fumarate. Carnitine, therefore, has two parts to play in the production of long-term energy from the fatty acids contained in body fats.

Since the fatty acid triglycerides contained in body fats are a major source of energy in the heart and skeletal muscles, it is easy to understand how L-carnitine is believed to lead to the increased energy levels required for stamina and staying power. A major reason for its effect on longer-term or extended energy requirements is that in enabling stored body fats to be used for immediate and longer-term energy requirements, L-carnitine allows emergency glycogen stores to be retained for use once immediate fatty acid supplies or those of carnitine have been depleted, and so allows the energy supply to be extended even farther. Research has also suggested that the amino acid can possibly be used to treat liver and kidney disease, diabetes and chronic fatigue syndrome.

As with many supplements, the question is often asked how does L-carnitine work in practice as opposed to the claims made for it by the supplement providers? Recent research indicates mixed results, but sufficient to justify its use. It is generally accepted that a supplement is necessary when there is a deficiency, but once that deficiency has been corrected further intake is unnecessary. However, it is also believed that during long and extended periods of exercise a carnitine deficiency does occur as L-carnitine is used up, and the supplement is necessary to ensure sufficient energy supply throughout the period of exercise.

There has also been a case reported in the Journal of Clinical Neurology (Negoro, Tsuda, Kato & Morimatsu, 1995) where a deficiency, caused by anorexia nervosa damaging the liver to the extent that it was unable to synthesize L-carnitine, was remedied by means of an oral supplement. Studies on endurance athletes have been mixed, ranging from no effect to L-carnitine being found to promote weight loss.

Carnitine has no unknown harmful side effects, and has been studied for medical applications other than as an energy supplement. For example it possesses extensive antioxidant properties, and can be used as a supplement against oxidative stress and the prevention of the lipid peroxidation that is a precursor to atherosclerosis.

Its use in osteoporosis and reducing bone mass is also being studied. The concentration of L-carnitine diminishes with age, and affects fatty acid metabolism in a number of tissues. Bones are particularly affected since they require continuous reconstruction. Without detailing the biochemistry involved in this, administration of carnitine helps to reduce the speed by which this occurs. Trials are so far been carried out only on animals.

In studies on both healthy volunteers and patients with type II diabetes, L-carnitine was found to improve storage of glucose in both groups, although its oxidation increased only in the group with diabetes. Other studies carried out include improving the function of neurotransmitters in the brains of elderly patients and in the treatment of Alzheimer's and Parkinson's disease, and other neurological disorders.

In conclusion then, although the jury is out on the use of L-carnitine is an energy-giving or weight-loss supplement, it appears to be effective where the body's stores of carnitine could be depleted such as with long-term exercise, natural deficiencies or deficiencies caused through age. It is also under study in the treatment of various medical conditions. On balance, it would appear that the prospective benefits of L-carnitine render it worthy of use.

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Grape Fruit Pectin Fiber
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Date: October 21, 2008 12:56 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Grape Fruit Pectin Fiber

Grapefruit pectin fiber is a source of soluble fiber that can bind to cholesterol and inhibit the formation of atherosclerosis. It is also effective in maintaining good blood sugar levels, and promoting a healthy colon. However, before discussing how grapefruit pectin fiber works in these ways, it is first necessary to explain how they occur in the first place.

CHOLESTEROL LEVELS

First cholesterol. This is a steroid lipid, most of which is biosynthesized by your body rather than being present in your diet. Although it has a bad name health wise, cholesterol is actually essential to good health because it helps your digestive system break down fast, it strengthens cell walls and is a major ingredient in the manufacture of vitamin D by your liver. It is also essential for the formation of several hormones, including cortisone, cortisol and aldosterone by the adrenal glands, and also of estrogen and testosterone. A bloodstream without cholesterol is therefore not good for you.

Given that cholesterol is essential for good health, then why does it have such a bad press? The root cause of that is that cholesterol is not water soluble, and to be carried round the bloodstream to where it is needed it needs some transport. For that, it uses low density lipoproteins (LDLs). However, it’s not a return journey, and to get back they must use another form of lipid known as a high density lipoprotein (HDL). The protein part is water soluble, wile the lipid part can attach to the cholesterol and carry it around the bloodstream.

The problem arises with free radicals, which are oxygenated molecules that are generated by the body’s metabolism, and also created from pollutants, such as pesticides and cigarette smoke, and the UV portion of daylight. These can oxidize the low density lipoproteins so that they can be attacked by phagocytes (while blood cells) deposited as plaques in the artery walls. This hardens and thickens the arteries, reducing the heart’s blood supply which in turn can cause strokes and heart attacks.

This can be prevented in a number ways, the major of which are by consuming plenty antioxidants in your food, mostly contained in phytochemicals (plant chemicals), reducing your LDL cholesterol levels to the minimum needed by your body, and also by increasing the HDL levels in your bloodstream by as much as possible.

Grapefruit pectin fiber can bind to cholesterol, and prevent it from being deposited in the artery walls by the oxidized LDL. A sixteen week double blind study (neither the subjects nor those carrying out the test and analyzing the results knew who were given the placebo) found that grapefruit pectin successful reduced the low density cholesterol level of 27 subjects by 10.8% and overall plasma cholesterol by 7.6%. These volunteers were at a medium to high risk of atherosclerosis due to a high LDL cholesterol concentration in their blood.

Animal studies have also been carried out, whereby animals were fed a high cholesterol diet, and those fed a high fat diet were found to have an average of 45% narrowing of their arteries, and those fed the same diet, but with added grapefruit pectin fiber, were found to have only 25% narrowing, thus corresponding with the results of the human volunteers.

BLOOD SUGAR

It is essential that you maintain a stable level of sugar in your blood since the body reacts to low blood glucose by making you feel hungry, and thereby forcing you eat. If you are trying to lose weight you will find it very difficult if your blood sugar levels fluctuate. Grapefruit pectin can reduce the rate at which carbohydrates enter your bloodstream, and therefore the rate at which sugars are absorbed.

Studies have also indicated that pectin can even out your blood sugar concentration, so that you experience fewer fluctuations or sudden spikes that can make you feel either very hungry, and so binge on carbohydrates, or very satisfied so that you eat nothing at all. The maintenance of a stable level of glucose in the blood is necessary for a normal life since it is that that determine your need to eat food. If your blood sugar is low, the desire to eat high calorie carbohydrate food is uncontrollable.

This is the theory behind the so-called ‘grapefruit diet’. You eat a grapefruit prior to a meal, and allow it to be digested. The grapefruit pectin will make you feel full and so eat less, so that you can eat normal foods, but still lose weight. Many people take the grapefruit pectin in supplement form for its ease and economy of use. It is also more convenient since you don’t have to carry grapefruit around with you everywhere you go.

A Healthy Colon

Like any other soluble fiber, grapefruit pectin fiber is a dietary fiber that can help to maintain the health of your colon. In fact it is the only one of the basic four fibers of lignin, cellulose, hemicelluloses and pectin that is soluble. Although referred to as soluble, pectin softens and expands and provides substance and added weight to faeces in order to allow it to pass easier through your colon.

Other than ensuring the easy passage of your stool through your colon, and avoiding constipation, grapefruit pectin fiber can help to prevent excessive growth of bad bacteria in the intestine, and because it accelerates the passage of substances through the colon, there is less time for toxic or cancerous substances to be in contact with your bowel lining. It is that which causes bowel cancer, and grapefruit pectin fiber can help to prevent it.

Fiber can also help to prevent diverticulosis, where the intestinal wall develops small sacs and becomes weakened. It also prevents hemorrhoids, eases the symptoms of IBS (irritable bowel syndrome). In short, it offers many benefits for the health of your colon, and can help to cure many bowel conditions.

However, it is important that you don't just rush into using any form of dietary fiber, but take it gradually. You start with a small intake, and then increase it slowly; since it is not absorbed through the intestine too much can lie in your colon and ferment, causing any number of intestinal problems. When used properly it can ease the symptoms of irritable bowel syndrome, but if used to excess, or too quickly, can actually cause the same symptoms, in addition to blocking the absorption of essential minerals such as iron, zinc and calcium.

Grapefruit pectin fiber can do a great deal for health, including maintaining good blood sugar and cholesterol levels, and helping to keep your colon healthy. It is available in convenient supplement form, but make sure that you drink sufficient liquid each day in order to prevent the fiber blocking your intestine rather than allowing free passage of waste product into, through, and out of your colon.



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Garlic
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Date: September 01, 2008 01:04 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Garlic

Garlic is a member of the lily family, related to onions and chives, and offers many health benefits other than deterring vampires. There is now ample scientific evidence and proof of its beneficial effect on both a healthy immune system and the circulatory system.

The active ingredients in garlic are thiosulfinates, of which the predominant one is allicin, sulfoxides such as alliin and dithiins, of which ajoene is the most widely researched. These compounds are not only responsible for the pungent odor of garlic, but also for its benefits to your health. Among the other components of garlic are selenium, manganese and vitamins B6 and C.

Before considering the other effects of garlic on your health, we shall first consider how it benefits the immune system. The immune system is an essential part of human biology, and protects your body from invasion by pathogenic organisms. Without the immune system your body would rapidly be overcome by bacteria, viruses, fungi, parasites and other foreign bodies, and your body would rapidly fail to function.

The immune system consists of several components that can act in concert to protect you from these foreign invaders. It is too large a subject to be discusses in this article, although its major components are the thymus, the spleen, the lymphatic system, bone marrow, antibodies, and white blood cells of various types. Without it your body would rapidly be broken down to nothing, and would revert to a skeleton in a few weeks.

It is your immune system that causes inflammation, fevers, boils and pus. These are all examples of the immune system at work to protect your body, and even a fever is the immune system raising your body temperature to one that is unfavorable to invaders. Arthritis and hay fever are other examples of how your immune system reacts to invaders, in one case mistaking damaged joint tissue as being foreign and responding by causing inflammation to protect the joint, and in the other a reaction to invading bodies such as pollen.

So what does garlic do to help your immune system? Let's first have a look at the inflammatory reaction of the immune system, a prime example of which is rheumatoid arthritis. The inflammation is caused by compounds known as prostaglandins and thromboxanes, the biosynthesis in your body of which requires the enzymes lipoxygenase and cyclooxygenase (LOX and COX). If these enzymes can be inhibited, then the inflammatory response can be modulated, and LOX and COX inhibition is one of the studies currently being carried out into the treatment of some forms of cancers.

However, where garlic comes in here is that two effective non-reversible inhibitors of LOX and COX are the chemicals Di(1-propenyl) sulfide and ajoene, and both of these are components of garlic. Garlic can therefore be used, not to stop the inflammatory response altogether since it is an essential part of the immune system for certain infections, but to modulate it and protect you from the more severe effects of conditions such as arthritis - both osteo and rheumatoid - and asthma, which is also an immune response.

Allicin has been shown to work with vitamin C to kill certain types of bacteria and viruses, and can help the immune system to protect you from colds and flu, Candida and some gastroenteric viruses. It can also be effective against some of the more powerful pathogens such as tuberculosis. It should be stressed that garlic will not cure these conditions, but help the immune system to deal with them. In fact with respect to the common cold, a study at Munich University has shown that garlic significantly reduces the activity of kappa-B, which is a nuclear transcription factor that mediates the inflammatory response. In other words, the cold symptoms are greatly reduced.

This is significant, since increased kappa-B levels can be triggered off by any pathogen that causes an inflammatory response by the immune system (e.g. infection, allergens, physical trauma). The study showed that unfertilized garlic provided a reduction of 25% in kappa-B activity, while garlic fertilized with sulfur reduced it by 41%.

There have been other studies carried out that demonstrated that Helicobacter pylori, the organism responsible for gastritis and peptic ulcers, was less active in those that took a regular amount of garlic in their diet. This was shown by measuring the antibody concentration, and while H.pylori was found in both sets (with and without garlic in the diet), the antibody count in the garlic-eating set was much lower indicating a significantly lower population of the bacterium.

Another unexpected result was that a group taking both cooked and uncooked garlic had a lower antibody count than those taking either cooked or uncooked. This appears to indicate that cooking changes the chemical nature of garlic, so that both forms work together to provide a more potent effect that cooked and uncooked separately.

What has also been established is that odorless garlic has less of an effect on the immune system that natural garlic, so while the odorless type is more socially acceptable, it is not so good at supporting your immune system. The allicin levels in odorless garlic are very much lower than in the natural bulb.

Garlic has also been found to be able to help with certain types of cancer. Two servings weekly have been found effective in protecting from colon cancer. Allicin has been found to protect colon cells from the toxic effect of various chemicals, and also reduce the growth rate of any cancerous cells that develop. People in Southern Europe consuming large quantities of garlic have been shown to be 39% less liable to contract cancer of the mouth and pharynx, and 57% less liable to contract cancer of the esophagus. It also had an effect on other cancers, including breast and ovarian cancer. However, the effect of onions on such cancers is even greater.

Most people are aware of the cardiovascular benefits of garlic, and it can reduce blood pressure, cholesterol levels and serum triglyceride levels, thus protecting against the harmful condition of atherosclerosis and also of diabetic heart disease. Reduced atherosclerosis means a reduced chance of heart attacks or strokes. It also appears to possess antioxidant properties.

There is no doubt that garlic helps to promote a healthy immune system, although the odorless form appear to be less effective in this respect as natural garlic, and there is evidence that a diet containing uncooked and cooked garlic can be more effective than either of these alone.

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Maitake Mushroom
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Date: May 24, 2008 12:12 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Maitake Mushroom

Medical practices treat the symptoms of disease. They do not prevent the illness itself. Alternative medicine offers a complement to the traditional methods. More and more physicians are realizing this and responding to it in their own practices.

It is becoming more common for physicians to enlist the aid of the natural world in treating their patients. Often, along with traditional medicine, doctors will suggest using a natural product in conjunction with a prescription. One such natural healer is the mushroom.

The Maitake and Other Mushrooms

Mushrooms come in many different varieties and species. They contain a large number of compounds that offer potent healing properties. One of the most useful species of healing mushrooms being recognized for its effectiveness is the maitake mushroom. This mushroom is being tested for its ability to enhance the production of infection-fighting cells in the human body.

Mushrooms are found in wooded areas all over the world and cultivated by both professionals and amateur collectors. If you wish to harvest your own mushrooms, it is vital to your health and safety that you research what each species looks like. Some mushrooms are poisonous to the point of being life-threatening.

These spongy fungal foods are used to make certain immune system enhancing extracts, either alone or in combination with other members of the healing mushroom family.

Mushrooms contain compounds known as alpha and beta glucans. These glucan phytonutrients are actually long-chain polysaccharide molecules. They consist of millions of glucose molecules that are chemically bound to each other.

The beta-glucan compound has been found to have great abilities to enhance the function of the human immune system. Lab studies are finding that the beta-glucans activate production of T-cells and NK (natural killer) cells. These are the cells that fight viral and bacterial infection and, in some cases, even cancer.

A healthy immune system is the only sure way for a human being to remain disease free. When the body’s immune system is not in optimal shape, infections attacking the body are much more serious and can even be life threatening.

The Different Healing Mushrooms

There are many different mushrooms that are studied and used for their medicinal properties. Of the many species of mushrooms, the most common and most used by alternative medicinal healers are:

* Maitake. The maitake mushroom can be found growing on oak trees all over the world. The maitake mushroom is best known for its ability to stimulate the production of T-cells in the blood.

* Shitake. The shitake mushroom is the best known and most widely used as an immune system booster.

* Cordyceps. The extract from the cordyceps mushroom has proven to be effective in fighting various forms of bacteria. It is also known to increase physical stamina. The sports world took notice of the possible benefits of cordyceps mushrooms in 1993 when nine women who were taking cordyceps reportedly broke world records at the Chinese National Games.

* Reishi. This mushroom has been used by the Chinese for thousands of years as an immune system enhancer.

Safety and Effectiveness

A consumer warning states that consumers should be aware of false advertising of mushroom extracts. Many beta-glucan products on the market are not 100% pure. A large number of them only contain about 1% beta-glucan. It is wise to always speak with a trained and knowledgeable store employee before purchasing any product you are unfamiliar with. It is also important that you read the labels of any product you are considering purchasing.

Although not widely recognized yet, the maitake mushroom is fast becoming a leader in the mushroom world for its immune boosting properties. Physicians and consumers are becoming more open to and educated about the medicinal uses of mushrooms. They are in abundant supply all over the world and are waiting to be discovered.

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What can we do about it?
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Date: June 26, 2007 02:01 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What can we do about it?

The answer to this problem is amazingly simple. It’s called remineralization. “Remineralization is important because we are missing the minerals and trace elements in our food that should be there,” says Joanna Campe, president of a non-profit organization called Remineralize the Earth. “We can address this by returning minerals to the soil just as the earth does. The natural formulation of soil occurs through the recycling of organic matter, the crushing of rocks onto the earth’s soil mantle by glaciers, and volcanic eruptions that add minerals to the soil. We can add these minerals back ourselves and create fertile soils.”

Remineralized soils can provide two to four times the yield of current unhealthy soils, and greatly increase the health of plant biomass—a well-validated fat that even amazed a group of missoouri high-school students who, in conducting experiments with remineralization, watched pecan plants germinate 7-9 days earlier and grow consistently faster than non-mineralized plants.

Remineralization is also fundamental in solving global warming. “When forests are unhealthy and dying off, they release carbon dioxide into the atmosphere,” Campe says. “When they’re healthy, they store carbon.” And remineralization’s effects are already being felt in this area. Highly successful remineralization on trees has been done by Dr. Lee Klinger, an independent northern California scientist. In the last three years his methods have been used on more than 5,000 Californian oak trees afflicted with malnutrition and other disease conditions, with all but a handful responding with a flush of healthy canopy growth (see www.suddenoaklife.org).

Additionally, there are early-stage studies indicating that spreading rock dust can help bind up atmospheric carbon in the soil and contract global warming.

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Vitamin D May Show Benefits Against Breast and Colorectal Cancer
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Date: February 27, 2007 02:09 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Vitamin D May Show Benefits Against Breast and Colorectal Cancer

Review and meta-analysis of several studies led researchers from several institutions to determine that an increased daily intake of vitamin D may significantly correlate with reduced incidences of colorectal and breast cancer. The breast cancer study pooled dose-response data from two earlier studies of 1,760 subjects. Subjects with the highest serum concentrations of 25-hydroxyvitamin D, or 25(OH)D (50 nanograms per milliliter), had a fifty percent lower risk of breast cancer compared to those with the lowest blood concentrations; less than or equal to 10 nanograms per milliliter. The colorectal cancer meta-analysis looked at fiver studies of 1,448 caucasian subjects. The authors estimate a two-thirds reduction in incidence with serum concentrations of 46 nanograms per milliliter, corresponding to a daily intake of 2,000 IU of vitamin D3. the researchers state the best way to achieve these concentrations is a combination of diet, supplements and 10 to 15 minutes per day in the sun. (Journal of Steroid Biochemistry Medicine, volume 32, Number 3, Pages 210-216)

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Remifemin symptomatic relief, scientifically supported*
TopPreviousNext

Date: August 26, 2006 02:41 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Remifemin symptomatic relief, scientifically supported*

Remifemin

 

Symptomatic Relief, Scientifically Supported*

 

The only RemiSure black cohosh

 

Unique to Remifemin® - Exclusive standardized isopropanolic black cohosh extract, subject of over 90 scientific papers.

Proven Effective – The most clinically studies natural intervention for menopausal symptoms with over 40 years of use worldwide*

 

  • Relief from hot flashes, night sweats, mood swings, irritability, and related occasional sleeplessness*
  • Particularly in women in early stages of menopause*

 

Safe – Completely hormone free

 

  • Works naturally without plant-based estrogens that can affect breast and uterine cell growth
  • Can be used safely by women with a history of breast cancer who cannot take estrogen

 

Efficacy

STUDY DESIGN

BENEFITS

DOSAGE

REFERENCE

1. Twelve-week, randomized, multicenter, double-blind clinical trial comparing the efficacy and tolerability of Remifemin® in the treatment of climacteric complaints compared with placebo.  The primary efficacy measure was the change from baseline on the Menopause rating Scale 1.

·          Remifemin® effectively relieved menopausal symptoms, particularly in women in the early stages of menopause*

·          Most significant reduction was in hot flash occurrence*

·          Other symptoms resulting in significant reduction include: psyche (irritability and memory), and atrophy (vaginal dryness)*

·          No significant adverse effects reported

40mg qd

Osmers R, et al. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms.  Obstet Gynecol. 2005 May; 105(5):1074-83.

2. A review of 29 randomized controlled trials of complementary and alternative therapies for menopausal symptoms.

·          Black cohosh is one of the only herbal remedies shown to be effective for menopausal symptoms, especially hot flashes*

 

Kronenberg. F. Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med. 2002 Nov 19;137(10:805-13.

3. Four-week, pilot study, open clinical trial of menopausal women with hot flashes, including women with a history of breast cancer.

·          Remifemin® reduced mean daily hot flash frequency by 50% after 4 weeks*

·          Overall, participants reported less trouble with sleeping, less fatigue, and fewer night sweats* 

·          No participants stopped therapy because of adverse effects

40mg qd

Pockaj BA, et al. Pilot evaluation of black cohosh for the treatment of hot flashes in women.  Cancer Invest. 2004;22(4):515-21

4. Double-blind study involving the use of Remifemin® in women ages 43 to 60 with menopausal complaints lasting 6 months.

·          Majority of woman saw a 70% reduction of physical and emotional symptoms after 12 weeks, including hot flashes, night sweats, mood swings, and irritability*

·          Significant improvement was noted after 4 weeks use*

·          Remifemin® works safely and effectively to treat menopause symptoms without affecting hormone levels or vaginal cytology (pap smear)*

40mg qd

Liske J, et al. Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizome): a 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health Gend Based Med. 2002 Mar; 11(2): 163-74

5. Double-blind, 6 month study in hysterectomized women under 40 with at least one ovary.

·          As effective as estriol, conjugated estrogens, or hormone combinations at decreasing physical menopausal symptoms at 4, 8, 12, and 24 weeks*

4mg dry extract bid (equivalent to 2 tablets Remifemin® bid

Lehmann-Willebrock E, Riedel HH. Clinical and endocrinologic studies of the treatment of ovarian insufficiency manifestations following hysterectomy with intact adnexa. Zentralbl Gynakol. 1988; 110(10):611-8

 

6. Women aged 45 to 58 with menopausal complaints were studied in a double-blind, 12 week, placebo-controlled trial.

·          Remifemin® decreased physical symptoms of menopause by approximately 60% (Kupperman menopausal indeed)*

·          Daily hot flashes decreased by 86% in the Remifemin® group(from 4.9 to 0.7 per day)*

·          Emotional complaints were also dramatically reduced*

4mg dry extract bid (equivalent to 2 tablets Remifemin® bid

Stoll W. Phytopharmacon influences atrophic vaginal epithelium: Double Blind study – Cimicifuga vs. estrogenic substances. 1987.

 

Safety

STUDY DESIGN

BENEFITS

DOSAGE

REFERENCE

7. in vitro, MCF-7 cell culture model to determine estrogen-agopnist and antagonist activity of commercially available herbal menopause preparations containing red clover, soy black cohosh, or a combination of herbs.

·          Remifemin® had no effect on estrogen-sensitive cells in vitro.

·          Results suggest safety for women with a history of breast cancer who cannot take estrogen.

In Vitro(10^3-10^5 dilutions)

Bodinet C, Freudenstein J. Influence of marketed herbal menopause preparations on MCF-7 cell proliferation.  Menopause. 2004 May-Jun;11(3):281-9.

8. Six-week, in vivo investigation of Remifemin®’s ability to stimulate estrogen-receptor positive cells in an animal model

·          No estrogen stimulating effects were found.

·          Prolactin, follicle-stimulating hormone, and luteinizing hormone levels were unchanged.

0.714m 7.14 or 71.4mg/kg/day

Freudenstein J, et al. Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract. Cancer Res. 2002 Jun 15;62(12):3448-52.

 

 

 

9. Comprehensive review examining all published literature pertaining to pre-clinical and clinical safety of various forms of Cimicifuga racemosa, as well as FDA and World Health Organization (WHO) adverse event reporting systems, monographs, compendia, internal unpublished data from a major manufacturer, foreign literature, and historical, anecdotal report.

·          Uncontrolled reports, postmarketing surveillance, and human clinical trials of more than 2,800 patients demonstrate a low incidence of adverse events (5.4%).

·          Of the reported adverse events, 97% were minor and did not result in discontinuation of symptoms, and the only severe events were not attributed to Cimicifuga treatemtn.

·          Confirms the safety of specific Cimicifuga extracts, particularly isopropanolic preparations (Remifemin®), for use in women experiencing menopausal symptoms and as a safe alternative for women in whom estrogen therapy is contraindicated *.

Various

Low Dog T, et al. Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom relief. Menopause: Journal of the North American Menopause society. 2003;10(4):299-313.

 

Relevant Reports and Guidelines

ORGANIZATION

PUBLICATION

EXCERPT OF KEY CONTENT

American Botanical Council

The ABC Clinical Guide to Herbs including a black cohosh monograph issues September 2002

“Of 10 clinical studies, including a total of 1,371 participants, nine of these studies demonstrated positive effects for menopausal symptoms.  Numerous clinical trials with varied methods and designs have been conducted on the standardized isopropanolic/ethanolic extract of black cohosh root, Remifemin®, from 1981 to the present.”

National Institute of Health

Questions and Answers About Black Cohosh and the Symptoms of Menopause issued October 2002

“Other preparations of black cohosh have been less well studied than Remifemin® …black cohosh is used primarily for hot flashes and other menopausal symptoms.  A number of studies using various designs have been conducted to determine whether black cohosh affects the menopausal symptoms… To provide more definitive evidence on the effects of black cohosh on menopausal symptoms, NCCAM is funding a 12-month, randomized placebo controlled study to determine whether treatment with black cohosh is effective in reducing the frequency and intensity of menopausal hot flashes.”

The North American Menopause Society

Alternatives to Hormone Replacement Therapy: Suggestions for the North American Menopause Siciety issued July 2002

Reseach suggests that mild hot flashes can be relieved by consuming a serving of soy foods daily or taking a supplement of black cohosh.”

 

responding to the need for alternative menopausal symptom relief*

 

Natural, Safe alternative to HRT for menopausal symptoms*

 

  • Remifemin black cohosh was as effective as HRT for menopausal symptoms*

 

Superior Manufacturing Quality

 

  • Prepared according to Good Manufacturing Practice (GMPs) which ensure delivery of a product with the highest quality and consistency
  • Convenient dosing – one 20mg tablet twice a day (one in the MORNING, one in the EVENING)
  • 100% RemiSure black cohosh – not a combination of herbs

 

VitaNet Recommends Remifemin

 

  1. Remifemin unique standardized isopropanolic extract is the most widely studied and clinically tested natural alternative treatment for relief of menopausal symptoms.
  2. Remifemin black cohosh proven effective in reducing menopause and peri-menopause symptoms, including hot flashes, right sweats, mood swings, and irritability without estrogenic effects.
  3. Used safely by millions of patients worldwide for over 40 years.  Remifemin has been proven effective and is the most clinically studied natural intervention of menopause.
  4. Remifemin doesn’t have the side effects that are experienced with hormonal drugs prescribed for the relief of menopausal symptoms.

 

Lit source: Enzymatic therapy.

*this statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treate, cure, or prevent any disease.



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Your Cells Supercharge Your Cells
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Date: December 20, 2005 11:30 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Your Cells Supercharge Your Cells

Your Cells Supercharge Your Cells

The differences between aging and growing old are poles apart. Sure, they may sound similar in nature. But when you think about it, the two are as different as night and day. Growing old is about retirement and travel and enjoying what you’ve worked an entire life for. Aging, on the other hand, summons images of wrinkled skin, brittle joints, cloudy minds and medicine cabinets full of prescriptions. It’s safe to assume that the majority of us want to look, live, and feel better as we grow old. Not the opposite. Many of us are on the right track - committed to a healthy lifestyle that includes regular exercise and a well-balanced diet. And yes, these do serve as a solid foundation for good health during our golden years. It is our cells, however, that ultimately determine who grows old, and who just ages.

Still, slowing the proverbial hands of time is not all about health clubs and organic produce. If you want to grow old gracefully, you must nurture the ten trillion cells that defi ne you physically. Why? Because these cells are constantly under attack by free radicals - unstable molecules that either lack, or have an unpaired number of electrons. They scour the body in search of stable cells, and do whatever they can to rob them of their electrons, a process more formally known as oxidation. Considering that it’s environmentally impossible to completely avoid contact with the billions of airborne toxins that cause free radicals, the only other option is to safeguard your healthy cells. Making the commitment to a healthy lifestyle is the fi rst step in the process, and can be accomplished by eating healthier foods, exercising on a regular basis, and paying close attention to what you are exposed to environmentally.

The next step is to nourish and protect your cells. The best way to do this is to consume foods that are rich in antioxidants and other cell-friendly nutrients. Unfortunately, this task is often much easier said than done. Today’s average adult is busier than ever, making it far more diffi cult to consume fresh, unprocessed meals 100% of the time. This does not, however, imply that all hope is lost. Over the years, the nutritional sciences have made stunning advances that afford you the opportunity to live your life while still safeguarding the integrity of your most basic building blocks. Here are a few of the best.

Antioxidants

Antioxidants work at the cellular level to paralyze the free radicals that cause oxidation throughout the body. Some of today’s most popular nutrients and dietary supplements fall into this category. They include vitamins A, E, and C, Selenium, Zinc, Alpha Lipoic Acid, Lycopene, Lutein, CoQ10, in addition to a host of others. And though similar in function, each of these free radical fi ghters has a unique role within the body.

Take CoQ10 for example. It’s present in every cell of the body, and is especially important for cardiovascular support. Lutein has been used extensively to prevent oxidation in the macular regions of the eyes. Zinc is a powerful immune system booster that has become extremely popular during cold and fl u season. Alpha Lipoic Acid is both fat and water soluble, and is commonly referred to as the “universal” antioxidant based on its ability to quench free radicals anywhere in the body.

Immune Boosting Herbs

Herbs such as Astragalus, Olive Leaf, Rhodiola, Echinacea, Panax Ginseng and Ashwaganda have been used for centuries to help support healthy cells and strong, responsive immune systems. They’ve also been shown to exhibit natural synergistic effects when used together. Today, they remain one of the most popular ways to naturally promote all-around wellbeing. When it comes to supporting healthy cells, NOW is pleased to offer one of the best selections of antioxidants, herbs and immune support formulas. Be sure to look for these and other great products at fi ne health food retailers, nationwide.*

OPCs

OPCs (proanthocyanidins) are high-powered polyphenol antioxidants that belong to the fl avonoid family. Grape seed extract, pine bark extracts such as pycnogenol and enzogenol, bilberry, gingko biloba, resveratrol and others all fall into this category. Research continues to suggest that OPCs work in the same manner that traditional antioxidants do, however their ability to eradicate free radicals is much greater and more versatile. Equally appealing, OPCs can easily cross the blood barrier of the brain to help protect brain and neural tissues from the damage caused by oxidative stress.

Mushroom Extracts

Throughout history, many civilizations have relied on organic mushroom extracts to encourage wellness. What we know now is that mushrooms such as Shiitake, Maitake, Reishi and others are rich in 1,3 Beta-glucans - soluble fi ber compounds that help support both innate and adaptive immunity. In addition, the active compounds in some mushrooms have been shown to stimulate the production of microphages, T cells, and other natural killer cells. These biological warriors serve at the front line when it comes to responding to bacterial attacks. They are of immeasurable value to the immune system, though drastically lacking in today’s average diet. In just the past few years, more and more healthconscious individuals have learned fi rst-hand how benefi cial they can be in the preservation of healthy cells.



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The Role of Naturally Occurring Progesterone in the Body
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Date: July 25, 2005 09:50 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Role of Naturally Occurring Progesterone in the Body

The Role of Naturally Occurring Progesterone in the Body

In light of the previous section, it is vital to keep in mind that when progesterone is produced and maintained, most of the negative side effects of estrogen are neutralized. Unfortunately, in far too many women, progesterone levels fail to do the job. Let’s discuss exactly what progesterone is responsible for.

A woman’s ovaries produce two key hormones: estrogen and progesterone during her ovulatory years. The corpus luteum makes progesterone just before ovulation which rapidly escalates during the two week period following ovulation. The primary task of progesterone is to support implantation and sustain pregnancy. It does this by inhibiting uterine contraction and by suppressing the immune system’s response to the developing embryo as a foreign body.2

During the last two weeks of a woman’s menstrual cycle, progesterone is considered the dominant female hormone. During pregnancy, the placenta takes over the task of progesterone synthesis. Progesterone is also made in limited amounts in the adrenal glands of both men and women and in the testes of the male.

PROGESTERONE SECRETION RATES

The following breakdown gives general guidelines of amounts and time of progesterone secretion:

  • • just before ovulation............................2 to 3 mg per day
  • • just after ovulation.............................20 to 25 mg per day
  • • one week post ovulation.........................30 mg per day
  • • during the 3rd trimester of pregnancy....300-400 mg per day Women who feel physically exhilarated and sometimes experience an unusual remission of diseases like bronchial asthma during pregnancy may be responding to elevated progesterone levels which help to boost the production of natural cortisone.

    Approximately twelve days following ovulation, if fertilization has not occurred, progesterone levels decline rapidly, which initiates the shedding of the uterine lining, also known as menstruation.

    In time, progesterone is transported through the bloodstream to the liver where it is metabolized and excreted as waste through the kidneys (urine) and the bile. Typically, pregnancy tests are reacting to increased levels of HCG or of progesterone in the urine, indicating that pregnancy has occurred. (Note: What is crucial to remember is that a woman’s cycle, regardless of her age, may not be characterized by the above scale. A number of factors may cause estrogen to remain dominant, even after progesterone is supposed to take over in the latter half of the cycle. Even young women who suffer from nutritional deficiencies, stress, etc. may experience an estrogen dominance, suggesting the need for natural progesterone supplementation.)

    THE THREE-FOLD ACTION OF PROGESTERONE

    1. It ensures the implantation and development of a fertilized egg and subsequent embryo and fetus.

    2. It acts as a precursor to other steroid hormones such as cortisone which is produced in the adrenal glands and contributes to the production of the sex hormones including testosterone.

    3. It exerts a number of desirable physiological actions.

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    Anti-Aging Nutrients
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    Date: June 18, 2005 09:07 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Anti-Aging Nutrients

    Anti-Aging Nutrients by Edward C. Wallace, DC, ND Energy Times, February 3, 2000

    What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful, easy feeling.

    How Do We Age?

    Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

    The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

    Programmed Cell Theory

    In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

    Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

    Free Radical/Oxidative Stress Theory

    The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain. On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents.

    Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution. Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

    DNA Repair Theory

    Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

    What Can We Do?

    The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

    In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

    Antioxidant Protection

    Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

    Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.) Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

    In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725). Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

    Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

    Nutrition Deficiencies

    A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

    When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

    A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

    Longevity Diets

    A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460).

    Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers (Epidemiology 3[5], 1992: 389-391).

    Staying Alive

    Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

    Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

    In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

    Longevity and Exercise

    Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

    Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184). In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

    The Treadmill of Life

    The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying (JAMA 273 [14], April 12, 1995: 1093-1098).

    Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

    Longevity Supplementation

    Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging. Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

    Toning Down Enzymes

    Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls. In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

    In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

    The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

    Vitamins E & C

    A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

    Chronological Age Vs.Biological Age

    Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems.

    In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

    Similar Relationship

    A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less.

    And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

    The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

    Carotenoids

    When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

    Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119[1], Jan. 1989: 112-115).

    Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

    Flavonoids

    Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs. For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

    Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

    Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

    Amino Acid Health

    Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68). As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

    Attitude & Behavior

    Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit. In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

    In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

    Longevity at Last

    While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of longer life. And by staying healthier, your old age will be more enjoyable, too.



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    Gotta Habit
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    Date: June 14, 2005 06:26 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Gotta Habit

    Gotta Habit

    by Catherine Heusel Energy Times, October 1, 1998

    Quitting a bad habit presents quite a challenge. Just ask anyone who's ever tried to give up cigarettes. Or alcohol. Or even coffee. You start out with the best of intentions but cravings can push you off the straight and narrow. The result: giving up a nasty habit often means regenerating your resolve and trying again. And again. And again. While some blame an inability to give up a bad habit on poor will power, in actuality, the tenacious chains of these habits may derive from the body as well as the mind. "People don't seem to realize the effects these substances have on the body," says Joan Mathews-Larson, Ph.D., director of the Health Recovery Center, in Minneapolis, and author of Seven Weeks to Sobriety. Dr. Mathews-Larson is one of a growing number of addiction professionals who stress physical recovery when giving up a drug, whether it's caffeine or cocaine. "You can't disrupt your internal chemistry for months or years on end and then expect your body to automatically bounce back," she says. "You have to give it some help."

    Breaking Off is Hard to Do

    The substances we love to overdo all share a common characteristic: they mimic or enhance the body's chemical messengers. Opiate drugs such as heroin, for example, are virtually identical to substances called endorphins, neurochemicals that the body produces to mask feelings of pain. (When an injured Kerri Strug performed her final Olympic vault, her endorphins enabled her to push past her protesting nerve endings.) Stimulants such as caffeine and nicotine can provide a "rush" similar to that produced by adrenaline and noradrenaline, the neurochemicals that provide the quick and excited feeling that swells down your spine during frightened or thrilling moments. On the other hand, some drugs (notably alcohol and cocaine) boost the activity of several different neurochemicals, including those that control sensations of pleasure. From a biological perspective, then, none of the drugs that people take are totally unfamiliar to the body. Your body makes similar chemicals all the time, in response to specific events and needs. "The main advantage of drugs is that they act powerfully and immediately," explains Andrew Weil, M.D., in his book, From Chocolate to Morphine: Everything You Need to Know About Mind Altering Drugs. "Their main disadvantage is that they reinforce the notion that the state we desire comes from something outside us."

    Serious Disadvantage

    Another serious disadvantage of drugs resides in their impact on the body's everyday neurochemical balance. Under normal circumstances, the body maintains its internal chemical environment on a fairly even keel. It may pump out oodles of adrenaline in response to a specific threat, like a near miss on the highway, but for every such scary "high" a corresponding low sets in: that rubbery-kneed sense of relief you feel when things calm down.

    Over time, the body mistakes the introduction of mind-altering, foreign chemicals as an excess of its own production of neurochemicals. As a result it slows down its own manufacture of these vital substances. So when you stop drinking caffeine or other stimulating drugs, the body finds its neurochemical receptors begging for relief: Cravings raise their ugly heads while so-called withdrawal symptoms raise your discomfort level. A general sense of ill health sets in until the body's natural production of neurotransmitter production reaches an acceptable level.

    Healthy Behavior

    Breaking a bad habit may be complicated by a lack of regenerative health habits. "A proper diet is pretty low on an addict's list of priorities," says Mathews-Larson. "Most of the people we see live on fast food and junk food." Many people trying to give up bad habits are attacked by the chemical and physical problems resulting from eating fatty foods and not exercising: their bodies are chemically and physically challenged from a poor lifestyle.

    Fortunately, recovery from a bad habit can be enhanced by balancing your diet, exercising and using nutritional supplements to straighten out your interior biochemical environment.

    "We target substances that are essential for maintaining optimal brain chemistry," points out Mathews-Larson. Foremost among these substances are a variety of amino acids that the body needs to rebuild its supply of neurotransmitters. In addition, nutrients such as B vitamins and vitamin C are often in short supply among those who indulge in addictive drugs and alcohol.

    Exercise and meditation are equally important to recovery, since both activities naturally prompt production of mood-enhancing neurochemicals. (The so-called "runner's high" is believed to result from endorphins and other neurochemicals stimulated by jogging.) More importantly, natural stimulation that pushes the body to create its own, endogenous supply of feel-good chemicals produces a longer sense of well-being than the transitory high induced by drugs and alcohol. "The potential for highs is always there, and many techniques exist for eliciting them," declares Dr. Weil. "Drug highs differ from other highs only in superficial ways."

    Natural Appreciation

    To experienced treatment professionals such as Mathews-Larson, kicking a long-standing habit depends on learning to appreciate the natural high of good health, through an overall healthy lifestyle. "It's not enough to just stop using the substance you abused," she contends. "You have to build a high quality of life for yourself, so you can fully enjoy every day."

    Recommended Reading: Seven Weeks to Sobriety, by Joan Mathews-Larson (Fawcett Books, 1997) Healing Anxiety With Herbs by Harold H. Bloomfield. (Harper Collins, 1998.)



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    Move it and Lose it! Burn off body fat!
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    Date: June 14, 2005 12:04 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Move it and Lose it! Burn off body fat!

    Move it and Lose it! Burn off body fat! by Mimi Facher Energy Times, June 1, 1997

    So you're feeling a little blah, a little overweight, and you're looking to drop a few of those winter pounds gained during the colder months. Maybe you've dabbled with diets and jogged around the neighborhood a few times but you're still packing unsightly bulges. If so, you may be considering the idea of turning to supplements to help you drop those pounds. Well, two types of diet supplements now generally available, combined with a diet and exercise program, may be able to help you trim those stubborn pounds.

    The first type of supplement, called metabolic optimizers, which include ephedra, caffeine and salicin (derived from willow bark), boost your metabolic rate, causing your body to burn calories faster. The second class, lipotropic substances, aid the body in fat mobilization, causing greater utilization of stored fat. These products include chromium, carnitine and hydroxycitric acid (HCA). Both classes of supplements have been around in various forms for quite a while but are now enjoying greater popularity among dieters.

    Trying to cope with a weight problem is a dilemma expanding throughout modern society. According to a 1995 Harris poll, nearly 75% of Americans are overweight. Although it's well known that the way to lose weight is to expend more calories than you take in, supplements may be able to help you burn off extra calories.

    Thermogenesis and You

    Metabolic optimizers are supposed to aid weight loss through a process called thermogenesis. Thermogenesis is a natural process in which fat is burned to produce body heat. Fat that isn't burned is stored on the hips, thighs, stomach, etc. Thermogenic agents are designed to counteract your body's fat storage mechanisms by causing your body to maintain a higher metabolic rate-turning your internal thermostat up to burn fat faster. The thermogenic process can be jump-started by a number of factors including cold, exercise, certain dietary nutrients and metabolic optimizers.

    Ephedra

    The ephedra herb, also known as ma huang is one of nature's earliest medicines, known for over 5000 years to the Chinese, who used it to relieve allergies, coughing, wheezing and cold and flu symptoms. In the US, ephedra has been available since the 1800s.

    The ingredients in ephedra include the alkaloids ephedrine, pseudoephedrine and norephedrine. Concentrated forms of these substances are used in today's over-the-counter cold, allergy and asthma relief formulas.

    Ma huang's effectiveness as a weight loss aid is tied to its appetite suppressant and stimulant properties. By speeding up action of the thyroid gland, the ephedrine found in the herb acts a thermogenic agent, boosting the rate at which the body metabolizes fat and promoting weight loss. According to Mark Blumenthal, Executive Director of the American Botanical Council, "When used as part of a total package that includes diet modification and exercise, ma huang can be highly effective in the short run because it increases the speed of the body's metabolism and suppresses appetite."

    Because of their strong stimulant effect, ephedra and its derivatives have engendered some controversy. However, in its long history, billions of doses of ephedra have been consumed without problem. But ephedra supplements should only be used as directed on product labels. People with cardiovascular problems, diabetes, thyroid or prostate dysfunction, high blood pressure and those taking MAO inhibitors, pregnant or nursing should avoid this herb.

    Salicin Burns Fat

    Salicin, a substance derived from willow bark-which is also the original source for aspirin, a related compound-can boost the burning of fat when combined with ephedra. An animal study in the American Journal of Clinical Nutrition found that while ephedra boosted calorie burning by almost 10%, when ephedra was combined with aspirin, extra calorie burning just about doubled. Another study in the Internatioanl Journal of Obesity showed that when overweight women took aspirin and ephedrine during a meal, their bodies burned off more calories than normal. (Eating a meal produces a thermogenic effect as your body expends energy in digestion. That's why dieters are told not to skip meals. Skipping meals lowers your metabolic rate, decreasing your calorie expenditure.)

    Similar studies also show that caffeine, the stimulant that gives coffee its eye-opening kick, can also boost ephedra's thermogenic properties. But before using these combinations check with a health practitioner knowledgeable about nutrition. Aspirin or salicin may cause stomach upset in some people (although salicin is generally tolerated well.)

    Carnitine: Lipotropic Amino Acid

    To get carnitine into your system, you don't have to take it as a supplement. Your body already makes this vitamin-like substance. However, your body doesn't make that much. And it is said to be especially low in people with heart disease.

    This non-essential amino acid (said to be non-essential because human bodies produce it) is a key ingredient in the formation of mitochondria membranes. Mitochondria are tiny structures in your cells that burn fats for energy. Consequently, sufficient carnitine is necessary for the movement of fat into the mitochondria where it is consumed. When not enough carnitine is present, the breakdown of long chain fatty acids slows down.

    Said to improve the recovery rate for athletes (it may limit the production of lactic acid, a waste product in muscle tissue), carnitine can also lower cholesterol levels, boost levels of HDL (the good cholesterol) and decrease serum triglycerides (blood fats linked to heart disease). Not bad for a nutrient that coaxes fat into those teeny, ceullular, mitochondrial furnaces.

    Go for the Chrome

    Chromium-based supplements work as lipotropic agents by aiding insulin use in the body. This essential trace mineral is required for normal protein, fat, and carbohydrate metabolism. According to Dr. Michael Janson, author of The Vitamin Revolution in Healthcare and President of the American Preventive Medical Association (APMA), "Chromium is important for proper insulin activity. Insulin moves sugar into the muscle cells, where it is burned off as energy. Chromium improves the activity of insulin, and since insulin causes fat deposition, less of it means less fat deposition." Chromium has also been shown to build muscle tissue and to reduce LDL cholesterol, which has been linked to heart disease.

    Although the body's minimum requirement is low, the American diet tends to be deficient in chromium, in part because the mineral can be difficult for the body to absorb. The fact that, in nature, chromium is most powerfully concentrated in brewer's yeast, wheat germ and liver-items most Americans rarely eat-probably hasn't helped either. Other natural sources of chromium include whole grains, molasses and beef. But it is estimated that 50% of Americans are chromium deficient. An early study found that overweight adults taking a chromium supplement lost an average of 22% body fat, while maintaining or gaining lean body mass. In another study, athletes consuming 200 mcg. of chromium a day showed an average loss of 7.5 lbs. of body fat after six weeks, without a corresponding loss of muscle tisue. Overall, although some studies question chromium's precise effects, many experts are optimistic about this substance because of its relationship to insulin in the body's metabolism.

    Hydroxycitric Acid (HCA)

    Another possible addition to the dieter's arsenal is HCA. In nature, HCA appears chiefly in a fruit called garcinia cambogia (sometimes also called Malabar tamarind or brindall berry), a citrus plant found primarily in Asia, where the rind is often used as a flavoring agent. HCA works by inhibiting the enzyme in the body responsible for converting carbohydrates into fat. HCA causes calories to be burned in an energy cycle similar to thermogenesis and acts as somewhat of an appetite suppressant. HCA is also said to have a role in reducing triglycerides and LDL cholesterol levels.

    Several animal studies have shown that HCA caused significant weight loss without a reduction in lean body mass. In other words, the pounds that came off came out of fat stores, and not out of energy or muscle reserves. This means that HCA takes off not just weight but body fat, making it a potentially effective tool against weight regain.

    Dr. Elson Haas, director of the Preventive Medical Center of Marin in San Rafael, CA, and author of Staying Healthy With Nutrition: The Complete Guide to Diet and Nutritional Medicine, believes that HCA can be a helpful aid for dieters when used in combination with eating habit changes and exercise. He recommends an HCA and chromium blend for optimum appetite suppression. "This combination can keep the appetite down and reduce sugar cravings," he says.

    Although human research data on HCA is still in the preliminary stages, the animal study results are positive, and the supplement seems to have minimal side effects in most people.

    Some Overall Recommendations

    You are likely to lose weight faster if you eat sensibly. This means avoiding foods high in fat or sugar (which are the most likely to add to stored body fat), but it doesn't mean starving yourself. A sensible balanced diet, along with moderate exercise, is still the best prescription for weight loss. As Dr. Haas puts it, "I'm a firm believer in diet and exercise. Using supplements responsibly can help you to lose weight provided they're combined with dietary changes and exercise. They won't work if you don't change anything." No one is suggesting that dietary supplements are a miracle cure for being overweight-as always in self-health care, there are no magic wands. But, used as directed and combined with a good diet and exercise plan, you could find that these supplements might help you work your way to a slimmer you.

    Mimi Facher is a freelance writer who has contributed to Prevention, Cosmopolitan and Self.



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    Nutrients for Longevity
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    Date: June 10, 2005 09:59 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Nutrients for Longevity

    Nutrients for Longevity by Edward C. Wallace, ND, DC Energy Times, September 1, 1999

    What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful easy feeling.

    How Do We Age

    Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

    The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

    Programmed Cell Theory

    In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

    Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

    Free Radical/Oxidative Stress Theory

    The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain.

    On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents. Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution.

    Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

    DNA Repair Theory

    Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

    What Can We Do

    The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

    In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

    Antioxidant Protection

    Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

    Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.)

    Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

    In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725).

    Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

    Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

    Nutrition Deficiencies

    A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

    When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

    A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

    Longevity Diets

    A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460)

    Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers. (Epidemiology 3[5], 1992: 389-391).

    Staying Alive

    Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

    Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects. (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

    In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

    Longevity and Exercise:

    Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

    Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184).

    In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

    The Treadmill of Life

    The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying. (JAMA 273 [14], April 12, 1995: 1093-1098).

    Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

    Longevity Supplementation

    Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging.

    Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

    Toning Down Enzymes

    Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls.

    In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

    In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

    The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

    Vitamins E & C

    A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

    Chronological Age Vs. Biological Age

    Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems. In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

    Similar Relationship

    A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less. And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

    The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

    Carotenoids

    When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

    Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119(1), Jan. 1989: 112-115).

    Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

    Flavonoids

    Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs.

    For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

    Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

    Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

    Amino Acid Health

    Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68).

    As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

    Attitude & Behavior

    Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit.

    In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

    In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

    Longevity at Last

    While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of living longer. An added benefit: By staying healthier, your old age won't only be longer, it will be more enjoyable, too.

    And, who knows, if you hang around long enough, taking your nutrients and getting a comfortable amount of consistent exercise, while meditating and refusing to succumb to stress, that magic bullet that will keep you alive for centuries may be discovered. Some day a new antioxidant or other substance may finally prove to provide the elusive fountain of youth. Stay tuned.



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    Higher Mind - Smart Nutrients for the Performance of a Lifetime...
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    Date: June 02, 2005 12:18 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Higher Mind - Smart Nutrients for the Performance of a Lifetime...

    Our adult years are the time to reap the fruit of an active, meaningful life – appreciated by family and friends who value our experience and knowledge. For some, however, their later years are clouded by a mental decline that erodes their capacity to enjoy life. More of us are becoming apprehensive about the future health of our minds. Will we still be able to communicate our needs as well as our wisdom? As science focuses its investigative might on the workings of the human brain, new findings suggest that it is possible to enjoy a vital, healthy brain and mind – well into old age. Based on compelling research, Source Naturals formulated HIGHER MIND. It contains the most important Neuroceuticals™ now recognized by nutrition scientists – including phosphatidyl serine, a natural nutrient that promotes cognitive function. The connection is clear: nourish your brain; enrich your life.

    To have a healthy, well-functioning brain and nervous system, we need the correct nutrients. Our diets must provide the necessary raw materials for nerve cells to grow, for the synthesis of neurochemicals, and for the maintenance of nerve cell membranes. Nutritional deficiencies can alter the brain’s metabolism, which is expressed by changes in perception and thinking, behavior and mood.

    Brain Cells – Issued at Birth

    Before birth, neurons (nerve cells) are created at the amazing rate of 15 million per hour. As infants, we have over 100 billion neurons, but this is the most we will ever have because – unlike most other cells in our body – nerve cells do not reproduce. A different strategy is used to replace the neurons that are naturally lost throughout life: nerve cells repair themselves and grow by extending branches of nerve fibers called dendrites (from the Latin word for tree). These are the communication links with other neurons that form the circuitry of the brain. A single neuron may be in contact with up to a hundred thousand others! When the density of this fragile organic communication network decreases, we experience a corresponding decline in mental acuity.

    Brain Cell Membranes

    The membrane is the working surface of a cell. It needs to be strong yet flexible, so the cell can maintain its integrity and be able to move and change shape. The membrane regulates the flow of nutrients into the cell and the removal of waste, plus controls the passage of molecular messages from outside the cell to its interior. Membrane ion pumps use a third of the cell’s energy just to maintain the correct ratio of sodium to potassium. In neurons, a rapid exchange of sodium and potassium ions across the nerve membrane is responsible for their unique ability to generate the electrical impulses that are the basis of all communication in the nervous system. As cells age, their membranes become less fluid and more rigid. Key membrane molecules called phospholipids are crucial to the health of neuron membranes, allowing the brain to maintain its youthful quality. The phospholipids in HIGHER MIND – especially phosphatidyl serine and phosphatidyl choline – are essential nutritional supplements for the aging brain.

    Phosphatidyl Serine – Key to Cognition

    For the past decade, researchers have been investigating the role in brain health of a remarkable neuroceutical, phosphatidyl serine (PS). This key structural molecule is integral to the matrix of fats and proteins that compose cell membranes. Although PS is found in all the cells of the body, its highest concentration is in nerve cell membranes. PS is rarely found in the foods we eat, so the body has to synthesize it, but the process is energy- intensive and becomes less efficient with age. Consequently, our levels of PS tend to decline as we get older. PS taken as a dietary supplement is well-absorbed, readily reaching the brain, where it helps create more effective, well-structured nerve cell membranes. The positive effects of PS supplementation have been demonstrated by 23 clinical studies with over 1200 human subjects, ages 43 to 90. Consistent and statistically significant results have confirmed the value of PS in improving age-related cognitive decline, as well as in improving behavioral aspects such as apathy and withdrawal.1 A major study concluded that for one particular measurable parameter of higher mental functions, PS recipients achieved scores of persons roughly 12 years younger.2 Nerve Growth Factor (NGF) is one of the most important proteins the body makes. It enables neurons to extend dendrites out to other neurons, allowing the brain to maintain an effective communication network. In experiments, PS enhanced the production and reception of NGF, which tend to drop off radically with age.3 The effects of PS at the cellular level are manifest in the performance of the brain as a whole. Subjects taking PS showed increased levels of brain energy metabolism. This enhancement corresponded to higher performances on cognitive tests.4

    The Chemistry of Thought

    Science now understands the role of neurotransmitters in regulating the body’s complex network of behavior. Neurotransmitters are the chemicals used by neurons to communicate with each other. Activated by a neuron’s electrical impulse, neurotransmitters travel between nerve cells, where they excite or inhibit (in various degrees) the electrical impulse in neighboring cells. One of HIGHER MIND’S key strategies is to improve the brain’s ability to produce and use acetylcholine, a key excitatory neurotransmitter. Acetylcholine is essential for both the storage and recall of memory, and partly responsible for concentration and focus. It also plays a significant role in muscular coordination. Patients showing cognitive decline may exhibit reduced ability to synthesize and utilize acetylcholine.5 The chemical building blocks of acetylcholine and other neurotransmitters are called precursors. The most important one for acetylcholine is DMAE (dimethylaminoethanol). This natural substance is found in various fish, such as anchovies and sardines. Supplements of DMAE (and phosphatidyl choline) promote increased levels of choline in the brain. Acetylcholine is created when an acetyl group is attached to the choline molecule, with the help of choline acetyl transferase (CAT), a key brain enzyme. Acetyl L-carnitine is an amino acid that activates this enzyme. Acetyl L-carnitine may also help reduce lipofuscin deposits in the brain because of its involvement in the metabolism of fatty acids.6 Lipofuscin is composed of oxidized fats and proteins; the brown “age spots” on the back of an elderly person’s hand are made of lipofuscin. The amino acid L-pyroglutamic acid sensitizes the acetylcholine receptor sites on a neuron membrane. A given amount of acetylcholine will then have a larger, more powerful effect. Studies have shown that supplements of L-pyroglutamic acid seem to enhance the ability to focus, remember, and learn.

    Total Nutrition for the Brain

    The neurotransmitters dopamine and noradrenalin are critical to motor coordination, motivation, concentration, and alertness. Like acetylcholine, their production tends to decline with age. The precursors and activators of dopamine and noradrenalin included in HIGHER MIND are the amino acids N-Acetyl L-Tyrosine and DL-phenylalanine (DLPA), plus folic acid, vitamins B-3, B-6, and C. DLPA is also a precursor to PEA, a neuroamine that has a stimulating effect on the brain. Glutamine is an amino acid precursor to glutamic acid, a major excitatory neurotransmitter involved in mental activity and learning. Glutamine acts as an alternative fuel source for the brain when blood sugar levels are low. It also helps the brain dispose of waste ammonia, which is a natural result of protein breakdown but is irritating to neurons even at low levels. GABA is a dietary amino acid which is also an inhibitory neurotransmitter. GABA works to calm and balance the mind, enhancing mental focus. Along with taurine, these two relaxing neurotransmitters provide a balancing influence to the other, excitatory neurotransmitters. Taurine is found in brain tissue more than anywhere else in the body. It has antioxidant properties and serves as a nerve cell membrane stabilizer, preventing excessive or erratic electrical activity in the brain.

    The Importance of Magnesium

    Magnesium must be present in adequate amounts in the synaptic gaps between neurons or the neurons become hyper-reactive: causing noises to sound excessively loud and emotional reactions to be extreme. Magnesium also activates a key enzyme responsible for maintaining cellular sodium- potassium balance, which is absolutely essential to the electrical activity of nerve cells, as well as to the existence of the cell itself. (Cells would burst if the sodium-potassium ratio were wrong.) Magnesium also helps relax cerebral blood vessels and is important to the manufacture of ATP, the chief energy molecule of the brain. A buildup of aluminum has been found in the brains of some elderly. In 1989, the British medical journal Lancet published a study showing that drinking water with aluminum can increase the risk of damage by up to 50%. An abundant natural element, aluminum is now a common feature in our culture. It’s found in tap water, cookware, deodorants, beverage containers, baked goods, and of course as aluminum foil. In the brain, aluminum breaks down the structure of neurons – causing them to starve – by displacing magnesium from tubulin, a glycoprotein responsible for making microtubules. These tiny pipe-like structures within a neuron provide needed rigidity, as well as transport nutrients from the nucleus down the dendrites to the ends of the nerve cell. Magnesium malate is an excellent form of magnesium that ensures neurons receive this vital mineral.

    B is for Brain Vitamins

    HIGHER MIND also contains a high profile of B vitamins and other key nutrients that are often N A T U R A L S S O U R C E Strategies for Wellness SM ¤ lacking in older individuals. A deficiency in any of the B vitamins can alter nerve function and psychological well-being. Thiamine (B-1), known as the “nerve vitamin,” was first recognized because its deficiency caused beriberi, a degenerative nerve disease. Thiamine is part of the structure of nerve cell membranes and is important to the reparative process that neurons need to offset the stress of continual firing of the electrical impulse. Low amounts of thiamine can cause cell malnutrition in the hypothalamus, the brain’s memory center. 7 NAD and NADH, two coenzyme forms of Niacin (B-3), are the most plentiful coenzymes in the brain. They are essential to hundreds of enzymatic reactions, including ones that produce energy. NADH can stimulate the synthesis of key mood-elevating neurotransmitters. It is also one of the body’s most potent antioxidants. Pantothenic acid (B-5), cyanocobalamin (B-12), and folic acid are required to form the myelin sheath – the insulating covering of nerve fibers. A diet low in pantothenic acid has been shown to make test subjects emotionally upset, irritable, and depressed.7 A lack of B-12 can result in poor concentration and, in severe deficiencies, hallucinations. Pyridoxine (B-6) is precursor to over 60 enzymatic reactions and is involved in the synthesis of several neurotransmitters.

    Brain Power

    Brain cells almost exclusively burn glucose for their energy (other cells can also burn fat), and typically require 50% of all the glucose in the blood. Two B-like vitamins help in the utilization of glucose: PAK (pyridoxine alpha-ketoglutarate) may potentiate the effects of insulin and improve glucose utilization to the cells;8 Biotin is important for the transformation of glucose into energy in the brain. Lipoic acid and coenzyme Q10 are metabolic energizers that help produce ATP, the primary energy molecule in the body. Since the brain uses 20% of the body’s total energy supply, efficient ATP production is vital. Lipoic acid and CoQ10 are also powerful antioxidants that help regenerate other antioxidants in the body. The blood vessels feeding the brain become less efficient as we pass middle age. Since the brain depends on the bloodstream to deliver nutrients and oxygen and to remove waste, the quality of this blood flow is paramount to proper brain nutrition. Ginkgo biloba leaf extract has been shown in scientific studies to increase blood flow to the brain by helping vessels to dilate. It also promotes the smoothness and healthy integrity of blood vessel linings.

    For the Life of Your Mind Without proper nutrition, the brain will deteriorate; therefore strategies are needed to both enhance current brain function and protect it throughout life. Based on the latest scientific findings, Source Naturals HIGHER MIND is formulated with neuroceuticals that support the mental functions that tend to decline with age. They give your brain the nourishment it needs to integrate perception, memory, and learning into a more comprehensive awareness – so you can excel for a lifetime.

    References
    1. Palmieri, G., et al. (1987). Clin. Trials J. 24: 73- 83.
    2. Crook, T.H., et al. (1991). Neurol. 41: 644-49.
    3. Nunzi, M.G., et al. In Phospholipids: Biochemical, Pharmaceutical and Analytical Considerations (ed. I. Hanin and G. Pepeu).
    New York: Plenum Press, 1990.
    4. Heiss, W.D., et al. (1993). Annals N.Y. Acad. Sci. 695: 327-31.
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