Search Term: " Alkaloid "
Natural anxiety relief: Scientific study reveals how ashwagandha root can help
May 08, 2019 02:35 PM
The many health benefits of the ashwagandha root is well known to ayurvedic medicine. It is only recently that conventional medicine is becoming aware of this due to the increase in the number of published articles on the effectiveness of ashwagandha root. It is known that the ashwagandha root is a good adaptogen and it is prolific for combating stress, for giving support to the adrenal system, and also for help in balancing the hormones in the body. It can also serve as an exceptional herb for aiding sleep. This effect on the body is due to the richness of alkaloids including sioinidosides that can be found in ashwagandha root which makes it serve as a mild sedative for natural anxiety relief. A recent study in which 64 human subjects were used and half were given a placebo while the other half ashwagandha root extracts gave impressive results in showing that ashwagandha root extracts is effective for boosting resistance to stressors and can help adults suffering from chronic stress. Furthermore, there is no side effect with taking ashwagandha roots even if one is not feeling stress.
"This study further propels holistic medicine’s reach into the mainstream by confirming that ashwagandha root extract boosts resistance to stressors and can be safely utilized as an adaptogen for adults suffering from chronic stress issues."
Read more: https://www.naturalhealth365.com/ashwagandha-root-anxiety-2908.html
5 Reasons Why You Need To Include Beetroots In Your Diet, Today
January 01, 2018 07:59 AM
Beets are slowly becoming the new trendy thing. From their sweet taste to their versatility, it only makes sense that they are this popular. But even more than that, they're loaded with vitamins and minerals like manganese and vitamin c. They are also good for anemics due to their high iron and folate content. They also contain a great alkaloid known as betaine, known for its ability to help with liver functionality and ability to aid with diabetes.
"Beets are not only full of essential nutrients like vitamins B and C, iron, manganese, copper, magnesium, fiber and potassium, but they are also abundant in health-boosting nutrients that one may not get from anywhere else."
Read more: https://swirlster.ndtv.com/wellness-mother/5-reasons-beetroots-are-absolutely-great-for-your-body-1792953
5 Health Benefits Of Comfrey
July 02, 2017 12:14 PM
Comfrey, a weed common to the waters edges in Europe, has long been used as a medicinal plant. Since the Medieval period, this plant has been used as a natural remedy for a number of ailments. It has proven to be beneficial in a number areas related to healing of skin ailments, with boosts to the immune system and improved relief of inflammation. Though Comfrey does have some serious problems with toxicity due to alkaloid content. Usage of Comfrey can be done safely with positive effects.
"Researchers found that “a highly significantly and clinically relevantly faster initial reduction of wound size…was found.” They found that patients’ wounds took on average three days less to heal completely than the control group, and that there were no adverse effects or intolerability issues. It doesn’t get much better than that, folks!"
Read more: http://www.thealternativedaily.com/health-benefits-of-comfrey/
Bioperine: Powerful Synergistic Compound
May 29, 2017 12:14 PM
Bioperine is an extract found in many pepper plants. It is related to the turmeric family. It has been tested in animals to possibly lower cancer rates in humans. It can also possibly boost your metabolism and encourage weight loss. It is easier to introduce in the market as a food rather than a pharmaceutical supplement. The product can also warm internal body levels and improve digestion which helps your body absorb more nutrients. Bioperine is a relatively safe product.
"This novel compound is one of several bio-active alkaloids found in these plants, and offers a slew of remarkable health benefits"
Read more: https://www.organicnewsroom.com/bioperine/
Supplements That Help Mange Diabetes Without Meds
December 05, 2016 06:59 AM
Type 2 diabetes is the most common form of diabetes in the United States. Some studies have shown that patients with this condition are sometimes able to control their disease effectively with supplements instead of prescription medication. While there are different degrees of any disease, it is possible that a dietary change could help control the condition. Some of the supplements that may help include chromium, biotin, vitamin D, D-chiro-inositol, and berberine. As always, people should consult their doctor before changing any therapy.
"Experts say that in many cases, supplements can help manage Type 2 diabetes, the insulin-resistant form of the disease which is the most common in the United Sates."
A Natural Pain Reliever And Anti-Inflammatory - Akuamma Seeds
Natural Pain Reliever And Anti-Inflammatory
The Akuamma seeds originate from the Akuamma tree also referred to as Picralima nitida. The seeds have an extremely bitter nature and was commonly used as a pain killer in West Africa, mainly in Ivory Coast, Nigeria and Ghana.
The seeds were also used to treat malaria and diarrhea as it contains an anti diarrhea, anti inflammatory and muscle relaxant properties.Traditionally the seeds were taken orally and were often crushed or powdered. A hospital in Ghana began manufacturing the powder in a standardized 250g capsules.
The drug prompted medical research as it was sold countrywide and was accepted as safe and effective pain killers.The seeds contain five Alkaloids with akuammine, being the main Alkaloid. Akuammine stimulates the uptake of glucose and was used to treat diabetes mellitus in Nigeria.
Soaked in boiling water, Pricalima nitada barks, have proven to be effective in the treatment of tryponosomiasis or chagas diseases. The roots of the Akuamma tree can also be boiled and cooked for management of intestinal problems and stomach aches.
This seed is a natural pain killer, it should not be mixed with prescription drugs, and only adults 18+.
Typical dosages: is
Exploring The Benefits Of Cat's Claw Herb
Cat's Claw is a medicinal plant made from the root and bark. It has drawn the attention of Western herbalists and researchers while being ranked seventh of the best selling herbs around the world. The plant has two components that are vital; Uncaria tomentosa angUncaria guianensis.
Benefits of herb chaste berry for women
January 17, 2014 08:20 AM
Premestrual Syndrome (PMS)
Premenstrual syndrome impacts over 70% to 90% of ladies before menopause in the US and less for ladies in Southeast Asia in light of their contrast in living style and social structure. The event of premenstrual syndrome (PMS) have more than multiplied in the course of recent years because of the acknowledgement of it as a therapeutic condition that is initiated by bad eating methodology with high in soaked sustenance. Premenstrual syndrome is characterized as flawed capacity of the ovaries identified with the ladies' menstrual cycle, it impacts a ladies' physical and enthusiastic state, and frequently meddles with every day exercises as an aftereffect of hormone change. The syndrome happens one to two prior week’s monthly cycle and after that decays when the period begins. In this article, we will talk about how standing berry tree impacts ladies with PMS.
I. Definition Chaste berry tree is an exceptionally significant herb; it has been utilized as drug since old Greek for menstrual issue incorporating absence of ovulation. Today the herb is well known for treating side effects of hormone lopsidedness.
II. How chaste berry tree impacts ladies with premenstrual syndrome it hard to accept that chaste beery tree holds no plant estrogen yet has been adequately utilized within treating premenstrual syndrome due to the accompanying lands
1. Iridoid Chaste beery tree holds iridoid incorporating aucubin and agnuside which are frequently intermediates in the bio combination of Alkaloid. It serves to enhance invulnerable framework battling against irritation and serves to avoid muscle spam bringing about decreasing menstrual ache and spasms.
2. Androstenedione is the normal antecedent of male and female sex hormone generated by adrenal organ, chaste berry tree holds androstenedione which not just serves to tie the levels of terrible estrogen additionally equalize the levels of testosterone in the ladies figure bringing about decreasing the male example for some ladies with PMS.
3. Key oil Chaste berry tree holds cineol, pinene, castine and different substances, it serves to unwind the apprehensive framework and muscle that serves to diminish side effects of anxious pressure, for example, tension discouragement, menstrual agony and spasms brought about by over animated uterus muscle. It likewise serves to expand liver capacity for overall health.
4. Alkaloid As and Alkaloid, it serves to diminish the manifestations of breast delicacy and bosom ache brought about over preparation of prolaction prior and then afterward ovulation.
5. Progesterone The chaste berry tree serves to repress if the levels of progesterone in the event that it is excessively high or raise the levels of progesterone in the event that it is excessively low, in this way, diminishing the danger of hormone awkwardness between estrogen and progesterone.
The Facts About Herb Dopa Mucuna
December 15, 2013 05:17 PM
What is Herb Dopa Mucuna?
Dopa Mucuna has become used as an aphrodisiac. Which is still used to raise and help libido in both women and men. However it's an alternative treatment peculiarity now is extremely popular used as it provides potential and valuable results in managing Parkinson along with conditions. Pots include seeds called velvet beans or mucuna beans, these are glowing brown or black. Dopa Mucuna is generally be able to recover soil fertility and decrease weed infestation. In society medicine seeds can be used healing different conditions and disease. Mucuna beans have been used as a coffee alternate (ground and roasted) in Brazil, Central America, and other countries.
The primary acts of the plant are following :
You've surely would not heard about L-Dopa, except if you are associated with somebody who carries body builder or Parkinson's disease, you might not be familiar with about it. L-Dopa is a precursor to dopamine. The seeds of Mucuna bean is rich in lipids, protein, ash, dietary fiber, minerals, and carbohydrates. Moreover they are very high in sterols, Alkaloids, and saponins. Mucuna seeds (along with the seeds of every Mucuna varieties) include high level of L-dopa is an immediate precursor of the neurotransmitter dopamine.
How does it works?
Low dopamine ranges are related to psychosis, addiction, schizophrenia, depression, and Attention Deficit Disorder. Because dopamine itself is unable to move the blood-brain barrier, it is transferred in a precursor condition is an outline that causes the brain to generate dopamine. L-Dopa is simply like a precursor. L-Dopa is located to work in improving concentrate, relieving depressive disorders, and managing Parkinson's Disease.
How cat's claw as a natural immune system booster to treat and prevent diseases
November 01, 2013 07:51 PM
What is cat's claw plant
The root of the cat's claw plant, which is scientifically known as Uncaria tomentosa, contains compounds called pentacyclic oxindole Alkaloids (POAs) that are responsible for its healing powers. The consumption of the cat's claw roots in raw or extract form must not be mixed with other foods that may neutralize the helpful effects of the POAs. The name cat's claw is Latin and represents this woody Amazonian vine that has only recently grabbed the attention of scientists who now use high performance liquid chromatography to see the POAs and isolate them for medicinal purposes. Here is an explanation of how the herb works to treat or prevent diseases.
What does cat' claw plant benefits
The Alkaloids in the cat's claw herb are responsible for strengthening the immune system, but the specific benefits are as follows. In the digestive tract, the herb is able to treat Crohn’s disease, gastritis and duodenal ulcers, intestinal inflammation, parasites as well as balancing the intestinal flora. To the immune system itself, the herb stimulates the production of white blood cells to help combat arising problems of arthritis, rheumatism, chronic fatigue syndrome and infections by viruses or fungi. In South America, it serves as a birth control herb because of its associated properties of causing an unfavorable environment in the uterus thus preventing a fertilized egg from attaching to the uterus.
The anti inflammatory effects of the herb, together with its anti-tumor properties, all attributed to the Alkaloids, prevent the damage of cells in the body by free radicals. As a result, patients having weak immune systems are able to significantly improve their chances of fighting diseases when they take in the herb as a supplement or tea. It’s the procyanidolic oligomers (PCOs) that stimulate phagocytes, which are special immune cells that destroy viruses and other organisms causing diseases. Excess use of cat's claw extracts or the herb itself can lead to nausea and headaches. The recommended dosage is 250mg of the extract taken twice in a day, or a teaspoon of cat's claw tea mixed with warm water, taken at most three times in a day.
Can Butterbur Extract Help with Bladder Incontinence?
October 30, 2013 09:56 PM
What is ButterburIt is a shrub that usually grows in marshy ground. It is found in North America, Europe, and Asia. In ancient times, its leaves were used to wrap butter when it was warm. Despite the rather interesting use, it is a plant that has been used for medicinal purposes for quite a while now. It has over time proved effective for clearing headaches, reducing pain, fever, anxiety, and problems with the urinary tract.
Butterbur extract is derived from the roots, leaves and rhizomes. It is used in the manufacturing of tablets. Topically, it treats allergies, clears migraines and asthma.
How it helps elevate incontinence
The traditional use of butterbur in treating problems in the urinary tract is still applicable today even in modern medicine. Normally, it is neurons in the brain and in the bladder's smooth muscles that involuntarily influence the muscle that surrounds the bladder, referred to as detrusor muscle. The detrusor muscle will contract and expand depending on the amount of urine present in the bladder.
Incontinence results when the smooth muscle in the bladder contracts without any warning whatsoever. It is characterized by overly frequent urination, which is more than 3 times in 24 hours, urgency and leaking.
The extract works by relaxing the detrusor muscle which reduces pressure on the bladder. Its active ingredient is a compound known as petasin. The results can be seen after a minimum of 4 weeks. By the eighth week, they are even more pronounced. Patients can improve from a minimum of 30 minutes urination intervals to 150 minutes. There are absolutely no side effects. It is not recommended for expectant mothers, or during lactation.
However, it should be noted that unsaturated pyrrolizidine Alkaloids (PA) are present in the natural form which could lead to liver damage. However, after processing, the P.A.s are removed. It is always safe to check whether the processed one has got any.
Can Fenugreek Seed Help Lower Blood Sugar?
May 17, 2012 08:47 AM
The cells essentially need glucose since it supplies them with energy, and it is the simple sugar traveling in the blood that provides the cell with glucose. Glucose moves from the blood into the cells with the help of the insulin hormone. At times, the body fails at producing insulin or starts reacting abnormally to the insulin in the blood. This way, the cells are not able to use the glucose, which causes the glucose to continue accumulating in the blood until the glucose levels in the blood become really high.
The severity of this condition can lead to diabetes. Fortunately, people can keep their blood sugar levels in a healthy range by using fenugreek seeds, which is a herb this is capable of lowering blood sugar. Before consuming fenugreek, it is better if people consult their doctor and follow their doctor's advice.
What is Fenugreek?
Fenugreek or Trigonella foenum-graecum, is a plant that is also known as Greek hayseed, and it bears seeds. For thousands of years, the Fenugreek seeds have bee used in Ayurveda or traditional Indian medicine. Fenugreek is generally recommended as a remedy for digestive problems, since constipation is relieved and lactation is promoted by the seeds of this herb. Even diabetes, high cholesterol and inflammation can be treated using these seeds. Several biologically active components are contained fenugreek, which lessen the amount of blood sugar, lowering blood sugar levels.
What are the Properties Fenugreek?
Natural chemicals known as saponins and Alkaloids are contained in Fenugreek. The way in which carbohydrates are converted by the digestive system into glucose and way in which insulin is secreted and used by the body is affected by some of these compounds. The saponins cause lesser glucose to be absorbed from digested nutrients. The amount of insulin secreted by the pancreas and the number of insulin receptors on red blood cells are increased by the rest of the compounds. Abundant fiber is also contained in fenugreek seeds, as a result of which the absorption of the glucose derived from carbohydrate after a meal is slowed down.
Is There Any Evidence that Fenugreek Helps Lower Blood Sugar?
It has been suggested by several laboratory studies that fenugreek indeed keeps the blood sugar levels in control. The benefits of fenugreek and its seeds have also been suggested by several clinical studies with human subjects. While large trials have not yet been conducted, the present findings seem to be quite promising and definitely suggest that fenugreek effectively lower blood sugar levels.
Precautions and Recommendations
A variety of health food stores are currently selling fenugreek extract and fenugreek seeds. While there is no standard dosage of consuming the extract or the seeds, but it is better if about five grams of the seeds per day or one gram of the extract per day is consumed. Fenugreek might result in mild abdominal bloating or gastric upset, but overall it is regarded safe to use. Thus, consuming fenugreek seeds or extract can prove to be beneficial for the people who are suffering from high blood sugar levels or diabetes.
Why California Poppy is a Great Pain Reliever
March 31, 2012 07:49 AM
What Makes California Poppy So Good For Pain?
If you reside in California, chances are good that you are familiar with the California Poppy. Named as the state flower in 1903, the yellow poppy fields surround the bays as a sign that springtime is here. The botanical name is Eschscholtzia californica and this orange cup-shaped flower grows wild as an annual perennial in California and other southwestern states from April through August. It did not take long for settlers to realize that natural beauty was not all that the California Poppy had to offer.
The entire plant, from root and stem to leaves and seeds has been found to provide varying displays of physical and psychological healing properties. Although placed in the sub-opiate Papaver family, the yellow California Poppy is in no way an active source of opium as is its cousin, the red poppy. While the red poppy works to depress the central nervous system, the yellow poppy provides analgestic and antispasmodic chemical reactions that work on nerve and muscle pain.
For years, raw California Poppy root has been used as an immediate form of relief for toothache pain. By chopping off a segment of the root and applying directly to the source of the gum pain, instant relief is felt. This rare phenomenon is believed to be credited to the variety of benzophenanthridine Alkaloids produced in the root. Many medical compounds such as morphine and codeine have been paralleled to this natural ingredient for the pain alterning state that is delivered. It is believed that only 20% of all plants contain this form of Alkaloid that is known to relieve pain.
A Tincture for Pain
There are many organic sites that offer a tincture made from the roots and leaves of the yellow poppy. Fresh herbs that are compressed into concentrated form are found to be more effective than those that are dried. The active ingredients are mixed with an alcohol based liquid and used in a liquid or placed under the tongue. A measured amount can alleviate pain from menstrual cramping or intestinal discomfort. Anxiety or stress related headaches are also treated with tincture that reportedly gives relief within minutes. A tincture made with California Poppy has a shelf life of five years when stored in a cool, dark area.
Raising California Poppy
California Poppy is a wonderful way to add a splash of color around the outside of your house and also reap the benefits of the medicinal properties. The bright orange flowers love the sunshine and will stretch to find. You will be able to keep a natural pain reliever on hand for making tincture, extract or tobacco. Smoking California Poppy gives a relaxing way to end a hard day and relieve pressure and pain from sore muscles. Acting as a sedative, you will find yourself drifting off into a blissful sleep. California Poppy can also be used for restless leg syndrome and many have experience luck in treating ADD and other neurological problems.
Ever since the days of the native Indiana, California Poppy has helped to relieve pain occuring from different sources and remains a great healer to this day.
Bioperine Promotes Maximum Absorption
February 06, 2012 06:19 PM
Bioperine is an extract from black pepper that contains about 95 percent piperine. Piperine is an Alkaloid, the active substance that contributes to nutrients bioavailability and absorption. Bioperine can be combined with other specific nutrients to form different nutritional supplements that can be used for both animal and human consumption. Black pepper is mostly harvested before ripening, dried in the sun and then the extraction process begins.
How and why use of Bioperine promotes maximum vitamin absorption
Recent research has shown that the use of Bioperine, whose main constituent is piperine, increases thermogenic activity in the body. Thermogenesis is an accelerated metabolic process that takes place in the body cells in which conversion of glucose into energy takes place. An increase in absorption of discount minerals such as selenium and vitamins such as vitamin A has been witnessed to be triggered by the use of Bioperine. Piperine works through initiating the release of catecholamines hormones that stimulate thermogenesis. However, the nutrients should presently available during this time since; the process takes place for a short duration.
Piperine improves the necessary conditions of the intestines thus enhancing vitamins absorption. It alters the intestinal epithelial cell wall making it more permeable to vitamins and minerals. In addition, absorption of protein supplements such as those used by people who are on a dietary weight loss program is also increased. Several researchers have also shown that Bioperine has other benefits in the body, these includes the antibacterial properties and anti allergy properties.
Experiments prove that use of Bioperine increases vitamin and mineral absorption
Several studies on how much piperine promotes nutrients absorption have been carried out hitherto. For instance, an experiment was carried out on the effect of absorption of beta-carotene, vitamin B-6 and selenium which are fat soluble vitamin, water soluble vitamin and mineral in the form of selenomethionine respectively in the presence and absence of piperine. The experiment showed that absorption of these vitamins and mineral selenium increased appreciably when taken with Bioperine. There was 60 percent increase in absorption of beta-carotene and vitamin B-6 while 30 percent absorption was noticed for selenium. The experiment was carried out using 5 milligrams of Bioperine. Another experiment also showed a 30 to 200 percent increase in the absorption of Coenzyme Q-10.
Bioperine is the only piperine product to undergo comprehensive health tests and to be patented for the effect of increasing nutrients absorption, more so vitamins and minerals. By creating metabolic changes that require vitamins and minerals, Bioperine creates a nutritional need and then follows by increasing the nutrients bioavailability to meet the need. However, the process takes place in a short period. It is therefore advisable to co-administer minerals and vitamins with Bioperine so that they will be available during the right time for absorption. Unfortunately, research has shown that taking black pepper in its natural form does not yield the same results as those of taking Bioperine. This is mainly because the bioavailability of piperine is not that high in the natural form. Finally, antibacterial and anti allergy properties of Bioperine diversifies its application in medication.
How Does Prickly Pear Leaf Help with Blood Sugar Control?
August 02, 2011 02:02 PM
Prickly pear leaf is obtained from a group of cacti known for their positive effect on blood sugar. It is an important source of food and medication for Native Americans since prehistory. It contains unique compounds that display potent antioxidant activity. Studies have shown that its phytochemical content displays potential in the management of blood sugar and the treatment of type 2 diabetes mellitus.
Also known as nopales in its place of origin, all plant species referred to as prickly pear belong to the genus Opuntia. This genus comprises more than 200 species, but only a few are noted for their culinary uses. In Mexico and most of Latin America, it is consumed as a vegetable in general. The juice extracted from the prickly pear leaf is utilized in different niches of many industries. In food and drug industries, it is highly valued for its Alkaloids and polyphenols that exhibit bioactive properties.
Many health problems recorded in the past few decades have been linked to uncontrolled blood sugar levels. Complex carbohydrates present in the human diet are broken down into simple sugars. In particular, glucose refers to the sugar that enters the systemic circulation. Glucose takes on a central role at the cellular level. It fuels the physiological functions of all cells and tissues, including the brain and the heart. That being said, diets high in simple sugars have been tied to elevated blood sugar.
Researchers and medical professionals have noted several factors that lead to metabolic disorders. Genetic abnormalities are something we don’t have control of. On the other hand, lifestyle factors are quite the opposite. It has been reported that sedentary lifestyle and food choices play a major part in the development of illnesses related to glucose metabolism. Experts are convinced that some foods are detrimental to health, but there are sources of nutrition that help maintain healthy glucose levels.
Prickly pear leaf belongs to the group of foods that are good for blood sugar. Glycemic index measures how carbohydrates present in our diet influence blood sugar concentration. Simple sugars are always considered unhealthy forms of carbohydrates in that all of them possess a high glycemic index, which means glucose is released into the bloodstream at a very rapid rate. Foods that are easily digested to simple sugars, such as white bread and sweetened beverages, affect blood sugar in the same manner. Organic compounds that occur naturally in prickly pear leaf have a twofold effect. First, it helps lower the glycemic index of carbohydrates in our diet, and thus promotes a gradual release of glucose into the bloodstream. Second, it improves the hormone activity of insulin and fights its functional decline that results in insulin resistance, a common medical condition that precedes type 2 diabetes mellitus.
Grab some prickly pear leaf and take control of your life.
Relax With Passion Flower, and Overcome Your Insomnia
June 09, 2011 11:33 AM
Passion flower is used by many people to help them relax and overcome their insomnia. People who find it difficult to sleep have discovered that a few drops of passion flower extract or a passion flower tea before bed can help them relax and get to sleep. They are amongst a growing number of people trying to avoid diazepam and Valium as a means of relaxation and overcoming stress, because it doesn’t get them hooked.
According to a study carried out by some PhD researchers and reported in the Journal of Clinical Pharmacy and Therapeutics in 2001, the Alkaloids and flavones contained in passion flower are just as good as these oxazepams at calming your general anxiety levels, yet do not impair your ability to work as the likes of diazepams such as Valium do, and are also non-addictive.
Passion flower works by calming you down through its effect on the neurotransmitters in your central nervous system, and not only overcomes general anxiety symptoms, but helps you to relax and sleep well at night. It is a natural substance, unlike the synthetic chemical nature of diazepam and other oxazepams and many insomniacs find it a godsend.
What is Bioperine and How Does It Help with Absorption of Vitamins
April 21, 2011 03:14 PM
Get more from your food with Bioperine.
Bioperine is a patented form of an Alkaloid found in black pepper. It is derived entirely from piperine, an organic compound responsible for the spicy taste of black pepper and long pepper. Piperine has been noted for its thermogenic properties believed to speed up the absorption metabolism of digested foods. Recent studies have discovered that it also interferes with the release of enzymes that govern the bioavailability of drugs and supplements. By so doing, it enhances the rate of absorption of vitamins.
The human body has a complex mechanism of controlling the substances that get in and out of systemic circulation. The first pass occurs in the alimentary canal, where gastrointestinal enzymes break down substances into smaller compounds. It is believed that a very small percentage manages to undergo intestinal absorption after digestion. In general, this is the part where constituents of supplements remain undigested and instead enter the colon together with waste materials.
The liver plays a central role to the metabolism of drugs and most bioactive compounds. The compounds that pass the intestinal walls and enter the hepatic portal system, a group of veins that direct blood and other compounds from the gastrointestinal tract to the liver, is further metabolized inside the liver. Anything that the body considers foreign is sent to the kidneys and easily excreted through the urine. This is the reason why bioavailability is significantly reduced after ingestion.
Counteracts Effects of Enzymes
Bioperine is the only compound known to interact with enzymes that controls the metabolism of foreign materials within the intestinal epithelium. P-glycoprotein is released in the digestive tract to deal with drugs and xenobiotics found in our diet. Vitamins are no exception to the tightly regulated process of absorption in the intestines. These enzymes transport digested compounds to the liver.
It has been observed that piperine appears to reduce the expression of p-glycoprotein in the alimentary canal and other parts of the body. Proponents believe that bioperine, a purer form of piperine, is capable of counteracting the effects of the enzyme within the intestinal epithelium, making it easier for vitamins and supplements to enter the hepatic portal system.
Increases the Rate of Metabolism
Not all compounds that undergo the first-pass effect interact with the cells and tissues they are supposed to act on. If they should have an effect on any cell, they are still subjected to the actions of enzymes specialized for the expulsion of xenobiotics found in the systemic circulation and the rest of the body. For example, CYP3A4 removes foreign materials from the cells and facilitates their excretion.
Bioperine is touted to induce thermogenesis and stimulate cellular activities. By so doing, the effects of bioactive compounds are achieved while they remain inside the cells and tissues. The thermogenic properties of bioperine influence the rate of metabolism of digested compounds, including vitamins, minerals, and components of herbal preparations. Note that it can increase the update or prescription medications as well, so caution should be observed when consuming bioperine with medications.
If you want to give your body a nutrient boost, add bioperine to your supplement regiment to boost absorption.
How Do I Eliminate Parasites Naturally from the Colon?
April 11, 2011 09:36 PM
Intestinal parasites infect over 3 billion people worldwide. These worm-like organisms populate the gastrointestinal tract and interfere with the absorption of foods. In children they may slow the normal progress of physical growth and intellectual development. In adults they cause muscle weakness, vitamin deficiencies, and susceptibility to fatigue. People from all over the world may acquire parasites from contaminated water and infected soil. Deworming is an effective way to get rid of these parasites. Fortunately, there are many herbs reputed for their anthelmintic benefits.
Allium sativum, the popular spice known as garlic, is the best known anti-parasitic herb. Its wide distribution in every continent has enabled cultures from all over the world to take advantage of its medicinal uses. Garlic contains the organic compound allicin, which is the primary substance responsible for warding off worms and bugs that attack the plant. This is the same compound that destroys intestinal parasites, notably threadworms.
Juglans nigra, or black walnut, is recommended specifically for the removal of pathogenic microorganisms, yeast infections, and intestinal worms. It is a flowering tree that belongs to the hickory family, and anthelmintic extracts are derived from the juice of unripe walnuts. Its antifungal effects are very visible after topically applied to fungal infections such as athlete’s foot. When taken orally, it has been noted to be particularly helpful against tapeworms.
Hydrastis canadensis, called orangeroot or goldenseal in the vernacular, is historically noted for its ability to ease anomalies of the alimentary canal. It is rich in the Alkaloid berberine, which restores health to the damaged epithelial tissues of the intestinal walls and expels invasive microorganisms. In recent years it has been observed to act against the parasites E. histolytica, G. lamblia, and Plasmodium as well as the bacterium E. coli.
Artemisium absinthium, better known as wormwood, is an ingredient of traditional herbal preparation used for deworming in the Mediterranean region. The discovery of sesquiterpene lactones in the plant explained its bitter taste and supported its centuries-old use as a vermifuge. Recent studies point to its activities inside the human body that inhibit growth of the parasites Giardia, Plasmodium, A. lumbricoides, and S. mansoni and effectively expel them.
Seeds of pumpkin cultivars that belong to the species Cucurbita pepo have a long-standing association with the natural expulsion of intestinal parasites. Pumpkin Seed oil has a milder effect than other herbs but guaranteed to be the safest of all anthelmintic herbal remedies. It is most effective against tapeworms and roundworms. For better results, it is consumed in large quantities with ample liquids, and often ground into a pulp beforehand.
Syzgium aromaticum, or Cloves, refers to the dried flowering buds of the plant commonly used as a spice. It is often linked to Traditional Chinese Medicine and Ayurvedic Medicine and known for the treatment of digestive ailments. Its oil has been proven effective against infections induced by certain strains of bacteria and fungi. It contains sesquiterpenes that are believed to kill intestinal worms.
If you have worms, you can experience fatigue, malnutrition, and leaning development delays or mental foggyness. Taking an herbal remedy to help expel worms of any kind should be used with a yearly detox and cleans to maintain good health and wellness.
Can Butterbur Help Me with Migraines
April 02, 2011 12:14 PM
Butterbur and Headaches
Butterbur has helped countless of migraine sufferers for more than three decades. In Europe, it is available as a prescription drug, which neurologists have prescribed since 1972. It has been the subject of numerous studies and reviews in a span of 40 years that have come to a conclusion that it does alleviate symptoms of migraine and reduce frequency of attacks. It is one of the herbal remedies clinically tested in migraine centers in the US. To date there has been no recorded adverse effects and harmful drug interactions, and as such available in the US over the counter, no prescription required. It has been compared to beta blockers and anticonvulsants and in general believed to be better than both of these more common treatments.
Petasites hybridus, the common butterbur, is the herb where butterbur extracts are obtained from although other species that belong to the genus Petasites are also known to produce the same health benefits. Petasites comprises up to 20 plant species widely distributed across the globe, a number of which have been tied to folk medicine throughout the ages. Petasites hybridus is native to North America and thrive well in marshes and wetlands, where there is a significant amount of moisture in the soil.
American Indians have long used its rhizomatous roots to fight off headaches and inflammation-induced diseases, such as asthma attacks and hay fever. Indeed the discovery of the organic compounds petasin, isopetasin, and oxopetasin explained its long-standing association with the treatment of migraines and allergies. Today most butterbur preparations do not contain pyrrolizidine Alkaloids, which were identified to cause liver damage. That being said, it is still best to seek professional advice and ask assistance in choosing products from a reputable laboratory.
Interferes with Releases of Pain Chemicals
The phytochemicals unique to Butterbur have been well investigated, and results point to their effects on inhibiting the productions of local pain chemicals, which are pro-inflammatory in nature. Leukotrienes are lipid mediators that supervise the productions of other intermediaries of inflammation. Prostaglandins are responsible for vasodilation of blood vessels and their consequent sensitization to pain. Butterbur has been observed to influence these two pain chemicals.
Plays the Role of a Natural Beta Blocker
Beta-adrenergic antagonists, or simply beta blockers, are a class of drugs that target endogenous catecholamines implicated in migraine attacks. Epinephrine and norepinephrine are catecholamines that act on beta-andrenergic receptors, leading to a reduced blood flow in the brain. This results in the spasmodic contractions of cerebral blood vessels characteristic of migraines. Butterbur works on the principle of blocking the effects of catecholamines and inducing normal blood flow to the brain.
Produces No Known Serious Side Effects
Most analgesics and beta blockers have been associated with several adverse effects, which more often than not include nausea, dizziness, and muscle weakness. Many have been reported to cause weight gain. None of these have been linked to regular use of butterbur, one of the reasons why it has enjoyed a surge in popularity in recent years.
If you suffer from Migraine headaches, give butterbur a try!
What is Vinpocetine and How Does it Help with Memory?
March 24, 2011 02:18 PM
Vinpocetine And Brain Health
Vinpocetine is a derivative of an organic compound found in the plant species Vinca minor, or common periwinkle. It is best known for its neuroprotective effects and used in Europe and Japan in treatment of age-related cognitive decline. More often than not, its activities inside the human body are described as vasodilator, which means it increases blood flow. It has also seen a growing presence in the North American market as a dietary supplement.
Vinpocetine is available as a prescription drug in certain European countries and Japan and has shown to be speed up prognosis of patients who suffered cerebrovascular accident, or CVA, which is commonly referred to as stroke. Most cases of cerebrovascular accident are brought on by ischemia, or very poor circulation of blood to certain parts of the brain. This is exactly what vinpocetine is beneficial for, and recommended dosages have so far yielded very encouraging results.
Improves Blood Circulation in the Brain
It has long been postulated that one of the mechanisms of action of vinpocetine is limiting the effects of Na+ channels that are sensitive to voltage. This creates a neuroprotective effect believed to contribute to mental clarity and sustained attention. Striatal nerve endings produce extracellular Ca+ ions that induce neuronal damage through a phenomenon called excitotocity. High levels of Ca+ ions are now alleged to be correlated with voltage-sensitive Na+ channels. Striatal nerve endings see a decline in Ca+ ions when Na+ channels are influenced by vinpocetine, and in the process lessen excitotoxicity.
Attenuates Ischemic Neuronal Damage
In addition to limiting neuronal damage induced by excitotoxicity, which in turn results from cerebral ischemia, vinpocetine plays an active role in the upkeep of brain cells after being subjected to ischemic damage. As a vasodilator, it not only counters the effects of ischemia but also significantly increases the brain’s access to bioactive molecules like oxygen and other nutrients exclusively distributed by the circulatory system.
It also inhibits the enzyme phosphodiesterase, which is specialized for the breakdown of cyclic adenosine monophosphate, or cAMP, and cyclic guanosine monophosphate, or cGMP. By so doing, vinpocetine contributes to glucose metabolism and energy production in the brain, and at the same time, improves the distribution of bioactive compounds in the central nervous system.
Displays Neuroprotective Activities
Vinpocetine and its precursor belong to a group of indole Alkaloids known as tryptomines, which are present in the human brain and the rest of the central nervous system in minute quantities. These organic compounds make up several psychoactive drugs and in the human body act as neuromodulators and neurotransmitters in the form of melatonin and serotonin.
Vinpocetine in particular displays activities that are primarily anti-inflammatory in nature. Several studies point to its effects on the enzyme complex called IkB kinase, which regulates cellular responses to inflammation, by preventing the translocation of a protein complex called responsible for the process of inflammation within cells.
In a Nutshell, vinpocetine can help you think clearer and protect the brain from inflammation and free radical damage. Give vinpocetine a try today!
Catuaba bark and its benefits
October 18, 2010 08:21 PM
Catuaba Bark (Erythroxylum catuaba) is a small tree that grows and produces yellow and orange flowers. Its shape is oval, yellow colored and looks like a small inedible fruit. In Brazil, the catuaba bark belongs to the family Erythroxylaceae and grows mostly northern part in Amazonas in and many other areas. Today, in the mid-forests of Brazil the trees are harvested in the form of catuaba and are sold all over the world.
There are two types of catuaba, one is Big Catuaba and the other is Small Catuaba. The Big Catuaba is also known as Trichilia catigua that grows up to 6-10 meters tall in the mahogany family in Brazil. It is cream colored and referred as catigua and angelim-rosa. The Small Catuaba, also known as Erythroxylum catuaba grows up to 2-4 meters tall in Brazil. The Tupi Indians an indigenous tribe of Brazil came to know first the various incredible benefits of catuaba. They learnt that it has sex-enhancing properties.
Later the Tupi Indians came to know about many other health benefits it provided like pain relieving, control of fatigue, reducing nervous and depression, sharpening memory. They were so impressed with the incredible and powerful action of catuaba that they spread the knowledge of its benefits to other Brazilian tribes and even praise the herb by singing songs. It is traditionally drunk by the Tupi Indians as a bark decoction by boiling it in water to make tea. This would improve sexual interest in people who lack sexual interest. Catuaba bark is a potent and a natural aphrodisiac. It remarkably enhances male's reproductive system, although this herb is primarily used to improve erection in men, it was found to be effective as libido-enhancing element for both men and women. It prevents us from feeling agitated and also helps in combating forgetfulness and dementia.
People feel more relaxed and energetic after taking it. Many others reported benefits of catuaba that it relieves from insomnia, hypertension, restless sleeping patterns and memory loss. It is non toxic in nature and is equal to aromatic oils, tannins and Alkaloids. Now-a-days this herb is available in all health food stores in the form of capsules with dosage of 500-1000 mg. You can also obtain the bark in tincture or powder. The significant feature is that it causes no side effects at all. Many researches conducted in Japan stated that the catuaba bark contains antibacterial and antiviral compounds as well. Many other studies also stated that it has relaxing effects and it tones the overall body functions.
Still various studies and research are going on Catuaba bark, since it also promises to prevent opportunistic HIV infections. If it is really does then it will be a great achievement to mankind.
Gentain Herb Can Sooth The Digestive Tract
December 17, 2009 04:23 PM
The gentian plant is an herbaceous perennial with fleshy root and fat hollow stems. The leaves of the plant are ovate and pleated, while the flowers are yellow. The root of the plant often smells aromatic and tastes sweet at first and then bitter.
Gentian was used as a stomach tonic and aid in digestion in Ancient Rome. This herb is native to Europe and western Asia. Generally, gentian was consumed as a tea or alcoholic beverage. Gentian was an official drug in the Untied States Pharmacopoeia from 1820 to 1955 and was used as a gastric stimulant. At one point in time, this herb was used and acclaimed by medical science as being very beneficial for mankind.
Gentian was used to reduce fevers by cooling the system. It contains a bitter principle, which is known as amarogentin, which stimulates the glands, and includes the adrenals and thyroid. This herb helps in the production of bile, which can have a positive effect on the liver and gallbladder. Gentian is also used to clean the bowels, stimulate the pancreas, stimulate circulation, aid in the digestive process, and help with female problems. This herb has historically been used to treat wounds and been taken internally for inflammation from arthritis, jaundice, and a sore throat. Gentian is considered to be a great herb for strengthening the entire body and for use as tonic when it is combined with other herbs.
German scientists have performed studies which confirm that this herb is useful as a digestive aid. Herbal bitters, including gentian, are recommended for the treatment of indigestion. The bitter taste receptors located in the tongue are known for their ability to stimulate the digestive processes by increasing the flow of gastric juices and bile. The Alkaloid found in gentian, gentianine, has been shown to contain anti-inflammatory activity in animal studies.
Internally, gentian is used as a liver tonic, to treat loss of appetite, digestive problems, flatulence, and insufficient production of gastric juices and saliva. This herb is responsible for stimulating the taste buds and promoting the flow of saliva, gastric juices, and bile. Because of this, gentian can be used in cases of anorexia, and in homeopathic medicine as well. There are no external uses or aromatherapy and essential oil uses for gentian. It should be noted that gentian should not be used by those with gastric or duodenal ulcers.
The root of the gentian plant is used to provide alterative, anthelmintic, anti-inflammatory, antiseptic, antispasmodic, blood purifier, emmenagogue, febrifuge, hepatic, sialagogue, stimulant, stomachic, and vulnerary properties. The primary nutrients provided by gentian include inositol, iron, manganese, niacin, silicon, sulfur, vitamins F and B-complex, and zinc. Primarily, gentian is extremely beneficial in treating loss of appetite, poor circulation, gastric disorders, indigestion, jaundice, and liver disorders. Additionally, this herb is very helpful in dealing with anemia, blood impurities, colds, constipation, stomach cramps, diarrhea, dysentery, fevers, gas, gout, heart burn, absence of menstruation, nausea, spleen ailments, urinary problems, worms, wounds, and yeast infections. For more information on the many beneficial effects provided by gentian, please contact a representative from your local health food store with questions.
November 25, 2009 03:40 PM
Fenugreek is one of the oldest herbal remedies, used for both a cooking spice and a medicinal remedy. Fenugreek is a plant that can be found in the family Fabaceae. This plant is used both as an herb and as a spice. The leaves of the plant are used as an herb, while the seeds of the plant are used as a spice. Fenugreek is cultivated worldwide as a semi-arid crop. Frequently, fenugreek can be found as a main ingredient in curry. Originally native to southwestern Asia, this herb was used for inflamed bowels and stomach problems because of its bowel-lubricating abilities. Fenugreek was used by the Greeks for respiratory problems. Additionally, fenugreek was used in both the East and West and thought of as one of the most effective medicinal herbs. Often, fenugreek plants were fed to sick animals to improve their health.
This herb has a reputation of being able to dissolve hardened masses of accumulated mucus in the body. Fenugreek helps to rid the lungs of mucus and the bronchial tubes of phlegm. Often, it is combined with lemon juice and honey to help expel waste through the lymphatic system. Fenugreek is known for the antiseptic properties that it contains, which help kill infections in the lungs. Additionally, this herb is recommended for treating an inflamed gastrointestinal system. This herb contains thirty percent mucilage, which may be used as a poultice on wounds, inflammations, boils, and skin ailments. Formulas containing fenugreek are often touted as the miracle medicine for all gynecological problems. Some studies have found that fenugreek simulates the uterus and contains diosgenin, a constituent similar to estrogen. Research on diabetic animals has found that Fenugreek seeds are able to reduce urinary glucose levels. The active ingredient seems to be the defatted portion of the seed, which possesses the Alkaloid trogonelline, nicotinic acid, and coumarin. When the defatted seeds were added to insulin treatment of diabetic dogs, it was noted that insulin dose was decreased. Fenugreek contains choline and liptropic, which aid in dissolving cholesterol and lowering cholesterol levels. Animal studies have shown beneficial results in lowering serum cholesterol levels. Fenugreek helps reduce mucus in cases of asthma and sinus and bronchial congestion. Evidence of anti-inflammatory activity has been show in some studies, which may explain why some individuals with arthritis have been helped by fenugreek.
The seeds of the fenugreek plant are used to provide alterative, anti-catarrhal, anti-inflammatory, antiseptic, aphrodisiac, astringent, bitter, demulcent, emollient, expectorant, febrifuge, galactagogue, mucilant, and vulnerary properties. The primary nutrients found in this herb are choline, iron, lecithin, minerals, protein, and vitamins A, B1, B2, B3, and D. Primarily, fenugreek is extremely beneficial in treating allergies, loss of appetite, bronchial catarrh, high cholesterol, diabetic retinopathy, gas, gastric disorders, lung infections, excessive mucus, and sore throat.
Additionally, the herb is very helpful in dealing with abscesses, anemia, asthma, body odor, boils, bronchitis, cancer, swollen eyes, fevers, gallbladder problems, heartburn, inflammation, sinus problems, ulcers, uterine problems, and water retention. For more information on the many beneficial effects provided by fenugreek, please feel free to contact a representative from your local health food store with questions.
Periwinkle - Vinpocetine
October 09, 2009 10:23 AM
Periwinkle can be found natively growing in North America, Europe, China, and India. The plant is a semi woody evergreen perennial. It is known by three names: Vinca, Periwinkle, and Myrtle. Typically, the plant is grown as an annual. It has a woody stem that can be found near the base and grows two to three feet tall and spreads out just as wide. The plant has a long life span of approximately twenty years. It also has a moderate growth rate. The plant has dark green foliage and bright blue flowers. The leaves are retained from year to year and are about two to three inches in length. This plant is very easy to grow, requiring little or no attention. Typically, it does best in poor, well drained soils. The flowers will suffer if the soils are too fertile. The periwinkle plant needs full sun or partial shade. It should be watered moderately during the growing season, but it is relatively drought resistant once it is established. The plant does not tolerate over watering. Fungus problems can occur in humid or wet weather.
For centuries, periwinkle has been used in different areas of the world to treat a variety of conditions. This herb grows in temperate climates and is often grown as an ornamental plant. Periwinkle juice from the leaves of the plant is used in India and applied to bee stings and bug bites. The plant grows well in Hawaii. The extract has been applied to wounds to stop bleeding. This herb can be found growing in South America and has been used for a wide variety of medicinal purposes. Periwinkle was used by native healers in Madagascar for cancer. Vincristine sulfate and vinblastine sulfate, two anticancer drugs, were developed from the periwinkle plant after the herbal healers in Madagascar were studied.
Periwinkle is considered to be a good binder. It can be chewed to stop bleeding in both the nose and mouth. It has been used historically for female complaints including excessive menstrual bleeding and uterine discharge. It also helps in aiding blood coagulation in wounds. This herb is effective in treating colitis, diarrhea, hemorrhoids, high blood pressure, headaches, migraines, nervous conditions, and diabetes.
Studies have found that periwinkle possesses anticancer attributes. Anticancer agents in periwinkle have been used to treat Hodgkin’s disease, leukemia, and cancer of the lungs, liver, and kidneys, along with other types of cancer. Periwinkle can be found natively growing in North America, Europe, China, and India. The plant is a semi woody evergreen perennial. It is known by three names: Vinca, Periwinkle, and Myrtle. Typically, the plant is grown as an annual. It has a woody stem that can be found near the base and grows two to three feet tall and spreads out just as wide. The plant has a long life span of approximately twenty years. It also has a moderate growth rate. The plant has dark green foliage and bright blue flowers. The leaves are retained from year to year and are about two to three inches in length. This plant is very easy to grow, requiring little or no attention. Typically, it does best in poor, well-drained soils. The flowers will suffer if the soils are too fertile. The periwinkle plant needs full sun or partial shade. It should be watered moderately during the growing season, but it is relatively drought r
The entire periwinkle plant is used to provide antineoplastic, astringent, hemostatic, nervine, and sedative properties. Primarily, periwinkle is extremely beneficial in dealing with cancer, diabetes, hemorrhoids, nervousness, and ulcers. Vincamine is an Alkaloid found in this plant has been studied and found to support cerebral blood flow, and oxygen and glucose utilization. It may also support cognitive function and enhance memory and concentration when taken regularly.
Additionally, the herb is very helpful in treating bleeding, congestion, chronic constipation, cramps, dandruff, chronic diarrhea, internal hemorrhages, leukemia, menstrual bleeding, excessive mucus, nightmares, skin disorders, sores, and toothache. In order to obtain the best results when supplementing with this, or any herb, it is important to consult your health care provider before beginning any regimen. For more information on the many beneficial effects provided by periwinkle, please feel free to consult a representative from your local health food store with questions.
October 06, 2009 01:22 PM
Goldenseal was used by the Native Americans as a tonic, for sore throats, eye infections, ulcers, and even arrow wounds. It was also used as an insect repellant and pesticide for crops. When boiled in water, it was used externally for skin conditions. The dried root of the goldenseal plant was official in the U.S. Pharmacopoeia from 1831 to 1842 and was readmitted in 1863 to 1936.
Traditionally, goldenseal has been used for many different conditions. Among these are boosting the glandular system, hormone imbalance, congestion, inflammation, female problems, infection, bronchitis, menstrual problems, catarrh of the bladder, gastritis, ulcers, bowel stimulation, antiseptic, and as an immune system builder. Those with low blood sugar or pregnant women should not use this herb.
Recent studies have determined that goldenseal is beneficial in fighting viruses and infections. This herb contains the Alkaloids hyrastine and hyrastinine, which possess strong astringent and antiseptic benefits on the mucous membranes. The berberine that is found in goldenseal, and can also be found in barberry, Oregon grape, and goldthread, is effective in fighting infections of the mucous membranes, which includes the mouth, throat, and sinuses. It has also been found to kill toxic bacteria in the intestinal tract like giardiasis, which is found in streams of North America. Goldenseal can help to relieve diarrhea in cases of giardiasis, amoebiasis, or other gastrointestinal infections.
The Alkaloid content of goldenseal gives it its antibiotic properties. Goldenseal has a long history of use for fighting both colds and flu viruses. The berbine content is effective as a natural antibiotic and immune stimulant. The herb may also help to prevent candida infection which is the result of antibiotic use. Goldenseal is thought to help strengthen the immune system and may work by increasing the blood supply to the spleen. This enables the spleen to function and release compounds which are known to improve immune function. Some herbalists in England consider goldenseal to be the wonder remedy for digestive problems. This herb is recommended for use after the onset of a cold instead of as preventative action. For this reason, it is often found in cold remedy combinations.
The rhizome and root of the goldenseal plant are used to provide adaptogen, alterative, anthelmintic, antibiotic, antiperiodic, antiseptic, cholagogue, emmenagoggue, hepatic, nephritic, stomachic,, and mild purgative properties. The primary nutrients found in this herb are calcium, copper, iron, manganese, phosphorus, potassium sodium, vitamins A, B-complex, C, E, and F, and zinc. Primarily, this herb is extremely helpful in treating bronchitis, poor circulation, colds, colitis, colon problems, coughs, diarrhea, eye infections, gonorrhea, gum disease, hemorrhages, hemorrhoids, infection, inflammation, intestinal problems, kidney problems, liver disorders, excessive menstruation, membrane infections, mouth sores, nosebleeds, and sore throat.
Additionally, this herb is very helpful in dealing with allergies, hay fever, asthma, Bright’s disease, burns, chicken pox, constipation, earaches, eczema, fever, flu, gallbladder problems, gastric disorders, gastritis, glandular problems, heart conditions, herpes, membrane irritation, nausea, nervous disorders, ringworm, skin disorders, spleen ailments, tonsitilits, and urinary problems. For more information on the many beneficial effects provided by goldenseal, please feel free to contact a representative from your local health food store.
September 02, 2009 11:55 AM
Both the Cherokee and the early American settlers used a decoction of hydrangea for calculous diseases with great success. This herb was considered by Dr. Edward E. Shook to be remarkable, with curative powers that were better than any other herb. This doctor also considered it a powerful solvent of stone and calculous deposits in the renal organs. This herb contains Alkaloids that act like cortisone without the side effects. Hydrangea also has similar cleansing powers to those of chaparral.
The hydrangea plant is a flowering shrub that grows easily and provides color in the garden from mid-summer through fall. Often, people use them as specimen plants and in shrub borders. The name hydrangea comes from the Greek hydra, which means water, and angeon, which means vessel. This refers to the plant’s preference for moisture and to the shape of the seed capsule. This plant is undergoing a revival of interest, which is much deserved. The hydrangea plant produces flowers from early spring to late autumn. These flowers are carried in bunches and found at the ends of the stems. Each individual hydrangea flower is relatively small, while the plant has large blooms that bring huge amounts of color to the garden in late summer and autumn. The plant is easy to grow, dependable, and improves with time.
Herbalists have found hydrangea to be a gentle and effective remedy. It cleans toxins from the body by cleansing the kidneys. Hydrangea also works to increase the flow of urine to remove stones and the pain that is associated with kidney stones. Hydrangea can help stop infection and dissolve hard deposits in the veins and urinary organs. This herb is thought to help with rheumatic conditions, work as a diuretic, help with bed-wetting, and treat lymphatic conditions.
When taking hydrangea as a supplement, one teaspoonful of syrup should be taken three times a day, or thirty grains of a fluid extract. As a tincture, one should consume two to four milliliters, three times a day. As a decoction, one should boil two teaspoons of root in one cup of water for fifteen to twenty minutes. The decoction should be drunk three times each day. Two to four grams of the dried root should be consumed for effective results. A one to one ratio in twenty-five percent alcohol of the liquid extract should be taken in dosages of two to four milliliters. Two to ten milliliters of a tincture prepared in a one to five ratio with forty-five percent alcohol will provide the best results.
The leaves and root of the hydrangea plant are used to provide alterative, antilithic, antirheumatic, astringent, diuretic, mild purgative, nephritic, and sialagogue properties. The primary nutrients found in this herb are calcium, iron, magnesium, phosphorus, potassium, sodium, and sulfur. Primarily, hydrangea is extremely beneficial in treating arthritis, cystitis, gallstones, gonorrhea, gout, kidney stones, rheumatism, and uterine problems.
Additionally, hydrangea is very helpful in dealing with arteriosclerosis, backaches, edema, inflammation, kidney problems, pain, and paralysis. For more information on the many beneficial effects provided by hydrangea, please feel free to contact a representative from your local health food store.
Freez Dried Nettle Leaf
August 15, 2009 02:07 PM
The nettle plant is native to Europe and can be found throughout the United States and into Canada. This herb was cultivated in Scotland for use in making a durable cloth. The nettle plant is so rich in chlorophyll that it was used by the English to make a green dye for camouflage paint. This camouflage paint was used during World War II.
Nettle is one of the most useful of all plants. It contains Alkaloids that neutralize uric acid. By decreasing uric acid, one can help to reduce symptoms of conditions like gout and rheumatism. Additionally, the astringent activity of nettle helps to decrease bleeding. The nettle plant is rich in iron, which is extremely vital to good circulation. It helps to reduce high blood pressure. Tannins that are found in the nettle root have been used as part of an astringent enema. This is used to shrink hemorrhoids and reduce excess menstrual flow. This herb became popular because of its use in irritating the skin of an inflamed area and increasing the flow of blood to reduce inflammation. The stinging action of nettle can be attributed to the histamine reaction that is caused by the formic acid in the hairs. Nettle has a reputation for use in cases of asthma and other respiratory conditions.
The use of nettle root extract was recommended by German physicians for treating urinary retention that is caused by benign prostatic hypertrophy. This recommendation was based upon evidence from clinical studies. Additional studies have determined that nettle root can increase the excretion of chlorides and urea from the urine. The diuretic activity produced by nettle root ahs been confirmed in animal studies. The diuretic properties can be attributed to the high potassium content. However, this has not been verified. A study that was conducted at the National College of Naturopathic Medicine in Portland, Oregon found evidence of nettle for treating hay fever. In this study, freeze-dried capsules of 300 mg were used. The results showed significant relief from hay fever symptoms in the participants.
The leaves and roots of the nettle plant are used to provide alterative, antiseptic, astringent, blood purifier, diuretic, expectorant, galactagogue, hemostatic, and nutritive properties. The primary nutrients found in this herb are calcium, chlorophyll, chromium, copper, iron, manganese, potassium, protein, silicon, sodium, sulfur, vitamins A, C, D, E, F, and P, and zinc. Primarily, nettle is extremely beneficial in dealing with external and internal bleeding, blood impurities, bronchitis, high blood pressure, rheumatism, and diarrhea. Additionally, this herb is very helpful in treating anemia, asthma, poor circulation, eczema, hay fever, hemorrhoids, hives, inflamed kidneys, excess menstruation, mouth sores, nosebleeds, skin disorders, and vaginitis.
In order to obtain the best results when supplementing with this, or any herb, it is important to consult your health care provider before beginning any regimen while on prescription medications. For more information on the many beneficial effects provided by nettle, please feel free to consult a representative from your local health food store with questions.
*Statements contained herein have not been evaluated by the Food and Drug Administration. Nettle is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication or adding Vitamins to medications.
BoneSet For Fevers
June 09, 2009 12:15 PM
Boneset was used by Native Americans for a valuable remedy against colds, flu, and fevers. Other common names that boneset is identified by include: thoroughwort, vegetable antimony, feverwort, agueweed, Indian sage, sweating plant, eupatorium, crossword, thoroughstem, thoroughwax, and wild Isaac. In most cases, boneset has been used primarily to treat fevers. They introduced boneset to the settlers in the New World. From 1820 through 1916, boneset was listed in the U.S. Pharmacopoeia. This herb was also listed in the National Formulary from 1926 through 1950. Boneset has been used to restore strength in the stomach and spleen. It has also been used as a tonic for acute and chronic fevers. Dr. Edward E. Shook actually felt that boneset was beneficial for every kind of fever humans are subjected to. He also believed that it had never failed in overcoming influenza.
Recent research has found that boneset contains antiseptic properties that help to promote sweating. These properties also help in cases of colds and flu. Boneset has also been shown to contain antiviral properties and strengthen the immune system by enhancing the secretion of interferon. Additional studies have found that boneset is effective against minor viral and bacterial infections by stimulating white blood cells. Additionally, this herb has been used to treat indigestion and pain and may also contain some mild anti-inflammatory agents to help with conditions like arthritis.
Boneset is a perennial herb that has an erect stout and a hairy stem. It grows from two to four feet high, with branches at the top. The leaves of the boneset plant are large, opposite, united at the base, and lance-shaped. They grow anywhere between four to eight inches in length and taper into a sharp point. The edges of these leaves are finely toothed, with prominent veins. These leaves help to distinguish this plant species at first glance. The flower heads of the boneset plant are terminal and numerous, being large, and having anywhere from ten to twenty white florets. The plant possesses an aromatic odor, with an astringent and strongly bitter taste. This plant species varies considerably in size, hairiness, form of leaves, and inflorescence. It can typically be found flowering from July to September.
The entire herb is used to provide alterative, anti-inflamamtory, antiperiodic, antiviral, diaphoretic, emetic, febrifuge, purgative, nervine, and stimulant properties. The primary nutrients found in boneset include calcium, magnesium, PABA, potassium, and vitamins C and B-complex. Primarily, boneset has been shown to be extremely helpful in dealing with chills, colds, coughs, fever, flu, malaria, pain, rheumatism, typhoid fever, and yellow fever. Additionally, this herb is beneficial in treating bronchitis, catarrh, jaundice, liver disorders, measles, mumps, Rocky Mountain spotted fever, scarlet fever, sore throat, and worms. For more information on the many beneficial effects provided by boneset, please contact a representative from your local health food store.
Although there is no recent clinical evidence that guides the dosage of boneset, traditional use of the herb suggests that a dose be about two grams of leaves and flowers. The internal use of this herb should be tempered by the occurrence of hepatotoxic pyrrolizidine Alkaloids in this plant. For those women who are pregnant or lactating, this herb should not be used, as there have been documented adverse effects on those women who are pregnant and/or lactating.
Boneset is available in capsule, tablet, and liquid extract forms at your local or internet health food store. Look for name brands to ensure quality and purity of the product you purchase.
May 13, 2009 12:39 PM
The barberry plant is a shrub that has gray, thorny branches. This shrub can grow up to nine feet tall. The flower of the barberry plant are bright yellow and bloom between the months of April and June. These flowers then become dark, drooping bunches of red berries in the fall.
The use of barberry dates back approximately three thousand years, originating in China in India where it was used for the treatment of diarrhea and intestinal infections. The barberry plant was used by Native Americans for treating liver conditions like jaundice. Additionally, Egyptians mixed the berries of the plant with fennel seed to protect themselves from the plague. Barberry is made up of an Alkaloid known as berberine, which can also be found in other medicinal herbs such as goldenseal and Orgeon grape. The therapeutic effects of barberry can be attributed to its berberine content.
Studies have concluded that berberine contains properties that are effective against a wide variety of bacteria, viruses, and fungi. These studies also found that berberine was much more effective in treating some bacteria than even a strong antibiotic. Other studies have found that barberry has the potential to kill microorganisms including staphylococci, streptococci, salmonella, Giardia lamblia, Escherichia coli, shigella, and Candida albicans. The berberine in barberry has been noted to contain antidarrheal properties. This Alkaloid is also recommended for stimulating the immune system.
The effects of barberry include helping against cancer, liver problems, kidney problems, coughs, cholera, diarrhea, fever, inflammation, hypertension, and tumors. Barberry has also been recommended to increase bile secretions and stimulate the appetite. This herb may also help in cases of anemia and malnutrition. Barberry stimulates bile production for liver problems and also dilates blood vessels to lower blood pressure.
Barberry is used in easing inflammation and infection of the urinary, gastrointestinal, and respiratory tracts, as well as candida infections of the both the skin and vagina. Barberry extract has also been shown to improve symptoms that are associated with certain skin conditions, such as psoriasis. However, more research is still needed on determining the reliability of these findings. Barberry is shown to be an extremely effective treatment for diarrhea. A few studies have found that barberry is able to improve symptoms faster than antibiotics. This is possibly because of its astringent properties. However antibiotics are still thought to be more effective at killing bacteria in the intestines. For this reason, it is best to use barberry to ease symptoms, along with a standard antibiotic, as bacterial diarrhea can have extremely serious consequences.
The bark, root, and berries of the barberry plant are used to provide alterative, antibacterial, antineoplastic, antiseptic, aromatic, astringent, blood purifier, cholagogue, diuretic, hepatic, hypotensive, purgative, and stomachic properties. The primary nutrients provided by this herb include iron, magnesium, phosphorus, and vitamin C. Primarily, barberry can be beneficial in dealing with loss of appetite, high blood pressure, impurities in the blood, candidiasis, constipation, diarrhea, dysentery, fevers, indigestion, infections, jaundice, liver disorders, pyorrhea, and sore throat. However, this herb is also extremely helpful in dealing with anemia, arthritis, boils, breath odor, cholera, gallstones, heart problems, heartburn, hemorrhages, itching, kidney problems, migraines, rheumatisms, ringworm, and skin conditions. For more information on barberry or to make a purchase, along with its many beneficial effects, feel free to contact a representative at your local health food store.
Cat's Claw Bark
December 19, 2008 09:54 AM
We are currently living in a time when vital health issues that greatly affect our families are a huge concern. Cat's claw has been shown to offer a huge array of therapeutic actions, as it is currently drawing a huge amount of attention in health-care. Because cat's claw has anti-tumor, anti-inflammatory, and anti-viral capabilities, it is currently being widely used in Europe for the treatment of cancer, aids, arthritis, and several other degenerative diseases.
Cat's claws emergence could not have been better timed, as many people feel that the war on cancer is being lost, with new potentially fatal viruses continuing to evolve and the over-prescription of antibiotics making us even more vulnerable to infection. Recently, taking supplements such as cat's claw is becoming more of the rule than the exception.
It is safe to say that almost all of us want to know how to reduce our risk of cancer, protect ourselves from toxins and pollutants, boost our immune system to fight off new viral strains and bacterial diseases, and prevent premature aging and degenerative diseases. Additionally, many of us have found that treating the disease after the fact is much less desirable than the protecting our immune systems, as a well-nourished and healthy immune system can keep us from developing diseases, including cancer. Cat's claw has the ability to fortify immunity, works to scavenge free radicals, and eases inflammation.
Cat's claw was traditionally used by Peruvian natives in a variety of applications. They apply its leaves for headaches, use teas for infections including influenza, and have placed plants in antipyretic baths for fevers. Additionally, gargles are used frequently and poultices of the boiled crushed bark have been applied to affected areas. Peruvian tribal medicine has also vigorously rubbed infusions of the raw bark on parts of the body, such as the limbs. The vines of cat's claw are often macerated with a pestle or stems are allowed to stand in water for several hours. In Peruvian culture, snuffing or smoking the dried leaves or bark occurs on occasion. Also, enemas are used in some regions of the tropical South America, but they are relatively rare in the Amazon.
Cat's claw can be taken in many forms including a dried, powdered form that is usually available in gelatin capsules; compressed tablets; a decoction or tea; or a liquid suspension that are in the form of gels or extracts, which can often be taken in soft gelatin form. Some experts seem to think that cat's claw extracts have not yet proven their potency and therefore, they recommend taking reliable sources of the plant which use the inner bark of the vine. The Alkaloid content of some plants can vary significantly because of many different factors, so only reputable sources of cat's claw are recommended to be purchased.
Many studies that have taken place in Europe have shown that cat's claw has extremely low toxicity, even when it is taken in large doses. Anyone who has had a transplant or any pregnant or nursing women should not take cat's claw. Taking cat's claw can potentially cause diarrhea or adjust bowel consistency in some people.
If one is looking for a immune boosting herb from the Amazon look no further, cat's claw can help the sick get well and keep the healthy person free from disease by boosting the immune system.
Red Pepper, Cayenne, Capsicum
December 18, 2008 04:51 PM
A remarkable whole body stimulant, Capsicum can boost blood flow, tone the nervous system, relieve indigestion, promote sweating, help to cauterize and heal ulcers, ease persistent pain, and fight off infection. One study on African plants found that Capsicum, when regularly ingested, is highly beneficial in hemorrhoids varicose veins, anorexia, liver congestion, and vascular conditions. The therapeutic actions of capsicum can be attributed to the Alkaloid or glucoside content of the herb.
Capsicum boosts peripheral circulation and stimulates organ secretion as it expedites the therapeutic delivery and action of other herbs. This allows the medicinal benefits of these herbs to reach the inflamed tissue more rapidly because of enhanced blood flow. Cayenne insures rapid and even distribution of the active parts of the rest of the herbs to critical parts of the body, which include those that are involved in cellular respiration, metabolism, data transmission, and neural-hormonal activation.
For this reason, cayenne is included in many other blends, as even extremely small quantities can dramatically increase the efficiency of most other herbs. Capsicum stimulates everything from blood flow to peristaltic action in the stomach, to intestinal transit time. Capsicum’s ability to stimulate organ secretion and heart action makes it one of the strongest natural stimulants that are known.
Capsicum is also known to be unequaled in its ability to boost circulation and increase heart action. Cultures that consume significant amounts of cayenne pepper in their diets have been found to have lower rates of cardiovascular disease. A variety of desirable actions on the entire cardiovascular system can be produced by Capsicum, with its extraordinary ability to enhance cardiovascular performance and lower blood pressure. Capsicum is considered a superior food for the heart by herbalists, where capsicum in hot water is thought to help lessen the severity of heart attacks.
Many studies have also been done on Capsicum’s ability to reduce the risk of developing atherosclerosis by reducing blood cholesterol and triglyceride levels. When cayenne is ingested along with dietary cholesterol, the typical rise in liver and blood serum cholesterol levels that ordinarily results was significantly inhibited. Additionally, bile acids and free cholesterol were subsequently eliminated from the body through the stool.
Another bonus of Capsicum is its ability to lower blood serum cholesterol, as it decreases blood pressure. There is additionally evidence that suggested that the herb is able to initiate other mechanisms that help in fighting hypertension. Because Capsicum stimulates organ secretion and boosts peripheral blood flow, it is not shocking that is also facilitates the faster removal of toxins from the blood stream and lymphatic system.
Additional benefits of Capsicum include its ability to boost the circulatory system, as it has the ability to help in preventing cold hands and feet, as well as Reynaud’s Syndrome. Capsicum also has antioxidant capabilities, making it a great scavenger of free radicals. Anti-cancer research has also found that Capsicum does demonstrate anticancer properties, as it inhibits certain enzymes that initiate the mutation of cells. This implies that taking Capsicum can give the body some protection against cellular mutation.
Capsicum has also been found to be an impressive pain killer, an anesthetic to ulcerated tissue, an aid in weight loss, a helper in psoriasis and rhinitis, and a reliever of fevers and chills. The list goes on and on, about the benefits of this amazing herb. Cayenne or red pepper can be found at your local health food store.
Horny Goat Weed
December 06, 2008 10:05 AM
Horny Goat weed, correctly named Epimedium, or Yin Yang Huo in Chinese, is one of over 60 herbaceous plants of the Berberdaceae family. It grows naturally in Southern China, and also in Korea, Southeast Asia and some parts of Europe. Other names given to include Fairy Wings and Bishop's Hat.
Horny goat weed has been viewed as a natural alternative to Viagra, and many species of Epimedium are said to possess aphrodisiac properties, and is said to have got its name from a Chinese goat herder who notice that his goats became more 'frisky' with the lady goats after eating the plant. In fact studies have indicated to increase vitality, particularly the libido and male sexual vitality, although it also possesses some other health benefits in its effect on dementia and osteoporosis.
The term 'horny' is used in the colloquial sense, and has nothing to do with the shape of the plant, the flowers of which are star-shaped. In fact the Chinese name for it means 'licentious goat weed', making the English translation quite clear.
The main ingredient in horney goat weed is icariin, a flavonoid glycoside that acts as a PDE5 inhibitor. Others include the similarly named, but totally different chemical, icaritin, and also many other that will be discussed later. It is icariin on which we shall focus for the time being. Since this is central to its effect on erectile dysfunction, some time will be spent on explaining what PDE5 inhibitors do.
cGMP (Cyclic guanosine monophosphate) is a chemical that relaxes smooth muscle tissue, including the vascular smooth muscles in blood vessels. This can lead to the dilation, or increase in size, of blood vessels and increased blood flow. The corpus cavernosum of the penis is a spongy area that runs the full length of the penis, and contains many blood vessels that can be dilated through the action of cGMP and allow the increased blood flow to create an erection.
PDE5 (phosphodiesterase type 5) is an enzyme that can degrade cGMP and prevent the relaxation of these blood vessels, and so prevent them from dilating. A PDE5 inhibitor, such as icariin, prevents the PDE5 from degrading cGMP, and so allow a normal erection. Sidenafil, commonly known as Viagra, is a similar PDE5 inhibitor and works in the same way as icariin. Hence, the effect of Viagra is not to create an unnatural erection, but in fact to allow the cGMP to do its natural work by preventing the phosphodiesterase from stopping it doing so.
This is just one of the effects of horny goat weed: it is a more natural PDE5 inhibitor than Viagra is. It is also more specific than Sidenfil, and does not interfere with any of the other phosphodiesterases that are essential for other purposes. However, its effects do not stop there, because icariin possesses other properties, and is also only one of the many components of epimedium that can increase vitality.
Among these are a number of flavonoids in addition to icariin, sterols and the isoquinoline Alkaloid magnaflorine, that possesses antioxidant properties and reduces LDL cholesterol. The exact mechanism by which horny goat weed works to increase sexual desire is unknown, but it is believed that it inhibits the enzyme acetylcholinetsrase (AChE). Cholinergic synapses are the spaces between brain cells that allow electrical impulses to be transmitted, and are an essential component of neuromuscular system response to stimulation.
AChE can stop these from working properly, and prevent neurotransmitters from effectively allowing sexual arousal. Horny goat weed can inhibit the activity of this enzyme and allow the neurotransmitters such as serotonin, dopamine and norepinephrine to do their proper job in allowing sexual arousal to occur. This, again, is a natural and not a chemical solution. It has also been found to reduce cortisol levels that cause stress which also reduces sexual desire.
The effect of Epimedium on smooth muscles can also aid those suffering from pulmonary hypertension, in which the small blood vessels in the lungs become too narrow to be effective in allowing the transfer between oxygen and carbon dioxide. PDE5 inhibitors can help these blood vessels to relax and so be more easily dilated in the same way as those in the corpus cavernosum. Once dilated, they are able to carry more blood to and from the lungs and allow the reoxygenation process to continue smoothly.
Research has also discovered the possibility of horny goat weed possessing monoamine-oxidase inhibition properties. Monoamine oxidase enzymes can deaminate hormones such as dopamine, and can significantly reduce the production of testosterone. The inhibitor prevents this happening, and leads to elevated levels of dopamine, and also of serotonin and noradrenaline. Dopamine encourages the pituitary gland to release luteinizing hormone that in turn promotes the production of testosterone by the testes.
Another property of horny goat weed is that it can protect against the toxin beta-Amyloid, a protein that damages DNA in the brain, causing the death of brain cells and the accumulation of dead cells in your brain. This in turn leads to dementia and potentially Alzheimer's disease. The use of Horny goat weed is being studied closely in relation to this property. The active ingredient here is icaritin (not to be confused with icariin)
Epimedium also has implications in the treatment of the cartilage and bone damage that occurs with arthritis and osteoporosis. It is possible that this is connected with the antioxidant and anti-inflammatory properties of magnaflorine, and icariin has been found to have bone-healing properties. It is known that damaged cartilage treated with horney goat weed displayed signs of growth and regeneration when compared to a placebo.
However, the most popular use of horny goat weed is in its effect on the libido and erectile dysfunction. The effect on the libido and sexual desire works equally well for men and women, and it is a preferred natural remedy to synthetic equivalents such as Viagra, Levitra and Cialis. The added benefits of the natural product render epimedium the preferred and safest solution for many people.
Huperzine And Memory
December 04, 2008 01:20 PM
Chinese club moss goes by the name Huperzia serrata, and gives its name to the sesquiterpene Alkaloid it contains: huperzine A. This Alkaloid has been found to be a superstar in the arena of brain-saving treatments for conditions such as Alzheimer's and age-related senility. Studies in China have found up to 60% improvements in the cognitive functions of such patients, and its potential has been recorded in the Journal of the American Medical Association. This is no mere folk remedy, and is the subject of serious study.
Known as Qian Ceng Ta, Chinese club moss has been a part of traditional Chinese medicine for centuries for the treatment of fever and inflammation, which is not surprising considering that most plants contain antioxidants and anti-inflammatories. However, what is unusual is the fact that it has also been found effective in treating some forms of dementia and depression, and also helps to reduce the incidence of panic attacks in those susceptible to them.
Not only that, but the plant has been found to possess diuretic properties, and a reduction in the swelling associated with water retention could also help to reduce the pain and other effects of swelling and inflammation. However, for now it is its effect on the brain that we are concerned, and research has indicated the likely mechanism by which huperzine A works.
Huperzine is an enzyme inhibitor - specifically inhibiting the enzyme acetylcholinesterase that breaks down acetylcholine, a neurotransmitter involved in the processes of memory, learning and mood. Outside the brain, it is involved in the movement of skeletal muscle tissue as well as in the regulation of cardiac and other smooth muscles such as those of the blood vessels.
When acetylcholinesterase (AChE) attacks acetylcholine (ACh), the latter attaches to a chemical site on the enzyme where it is then destroyed. It is a deliberate function of the body, designed to terminate a synaptic transmission. The purpose of a neurotransmitter is to allow the transmission of an electrical impulse form one nerve cell to another over a gap between them known as a synapse. Once the transmission has been completed, the enzyme can destroy the neurotransmitter, and then another takes its place. In fact one molecule of AChE can destroy around 5,000 molecules of ACh.
However, with age and for other reasons, these neurotransmitters can become depleted so that it becomes increasingly more difficult for brain cells to communicate with each other, and their destruction becomes undesirable. There are drugs available to help prevent this happening (e.g. donepezil, galantamine and tacrine), and so help to improve the memory and mental function of people as they grow older or contract conditions such as Alzheimer's disease.
Huperzine A has been found to take up the site in the acetylcholinesterase molecule that would normally have been used by the acetylcholine, and so save it from destruction. The more Huperzine A molecules present, the more acetylcholine available to pass messages between brain cells, and the stronger the cognitive function of the subject or patient. The pharmaceutical drugs mentioned in the previous paragraph work in exactly the same way.
This is a very specific reaction, one molecule adopting exactly the same space as the other, and has been proved scientifically by comparing the physical shapes of the two molecules. It's just like a jigsaw puzzle, where only one piece can fit into each position. Except here there are two: Huperzine A and acetylcholine both fit into the exact same place in the chemical structure of the acetylcholinesterase molecule.
The biochemistry of the reactions involved is very complex, and shall not be discussed here, but the upshot is that Huperzine A can do exactly the same job as modern drugs to avoid this hydroxylation of the ACh needed for the proper functioning of your brain.
In fact, clinical trials have indicated Huperzine A not only to be comparable in effect to the drugs current used, but also likely safer with respect to the possible side effects. This has still to be confirmed, but the National Institute on Aging is currently carrying out a trial to evaluate this claim in tandem with its effect on Alzheimer's disease. It has also been examined at Harvard University for its effect on epilepsy on patients with whom alternative pharmaceutical treatments have been unsuccessful.
Another suggested benefit of Huperzine A is that it is an NMDA (N-methyl D-aspartate) receptor antagonist that provides protection against damage to the brain by an excess of glutamates, and that it can also help to protect nerve cells from damage. Since NDMA is responsible for the transmission of some types of pain, the antagonist can also act as an analgesic.
There are other benefits that Chinese club moss can provide, and myasthenia gravis is one of them. Although relatively rare, this is a serious condition in which acetylcholine receptors are deactivated on muscle cells. This is achieved through the autoimmune system malfunctioning and creating antibodies against the receptors, and the end result is paralysis and respiratory failure.
Huperzine A reduces the AChE available and so might possibly enable the acetylcholine to work more effectively and delay or even stop the deterioration of muscle function. When people hear of muscle paralysis they frequently forget that breathing requires muscle function, as indeed does your heartbeat. This is currently surmise, and studies are being carried out to determine whether or not this usage of Huperzine A is viable.
Another promising application of Chinese club moss extract is in preventing organophosphate poisoning. These pesticides permanently suppress acetylcholine. This results in seizures due to a lack of interruption of the signals from nerves to muscles. The seizures can result in rapid death from uncontrollable seizures, or from permanent contraction of the diaphragm muscle that allows breathing. Although no human studies have yet been carried out, animals given Huperzine A prior to organophosphate exposure have survived without seizures.
There are no doubts that Chinese club moss and the Huperzine A extracted from it are effective in preventing the suppression of acetylcholine, and in permitting the proper activity of this important neurotransmitter. It is finding an increasing number of potential uses beneficial to the human body, not the least of which would be a partial remedy for some of the effects of dementia and Alzheimer's disease.
Guarana Seed Extract
November 17, 2008 11:24 AM
Guarana comes from the Amazon basin, and has been used by the natives of the Amazon rain forest to treat conditions such as diarrhea, arthritis, fatigue and even to reduce hunger. It is, in fact, a climbing plant of the Sapondacaea family, although it is the fruit for which it best known. Each contains a single seed that contains around five times the amount of caffeine of a similarly sized coffee bean.
An interesting piece of trivia is that the reason why such seeds are rich in caffeine is that the substance is poisonous to certain pathogens that would otherwise attack the berry. The same is - true of all seeds that contain caffeine: it is a means of self-defense. Obviously it is an effective defense since the berries appear to relatively immune to such common plant diseases.
Guarana is named after the Guarani tribe of South America, and the language is spoken by many in the area around Paraguay, Bolivia and Brazil, and also parts of Argentina. In fact over 67% of Paraguayans speak the language. There is a myth that when child of the Guarana village was killed by an evil god, a more benevolent deity planted the child's left eye in the forest and the right eye in the village. The left eye gave rise to the wild form of the plant, and the right eye the cultivated form.
This likely came about because of the appearance of the fruit when it is split open: it has the appearance of eyeballs. However, what is true is that Guaranis made tea from the seeds, and also a bread known as guarana bread by mashing the powder into a dough and shaping it into a cylindrical bread. It is dry roasted and milled to a fine powder, also known as Brazilian cocoa, but it has never quite managed to compete commercially against the coffee! However, it has its local adherents to whom it is a staple drink.
However, back to the health benefits of the seed. They were recognized as early as the 17th century when Father Felip Betendorf introduced it into Western civilization, but over the centuries since then it has been found that even in spite of the caffeine content it has been demonstrated to have brain-boosting properties and able to increase tasks requiring mental attention. It is certainly known to be an energizer, and able to give a boost to your brain when you really need it. So why should this be, and how does it do this?
The flavor is a bit like chocolate, hence its nickname of Brazilian cocoa, and has been approved by the FDA as a food additive. Extracts from the berry have been shown to possess strong antioxidant properties, and also act as bactericides and fungicide, few of which can be put down the caffeine content. In fact the seed has been proposed for use in the food industry as a natural antioxidant and preservative and as stated below, that is more acceptable to people than synthetic chemicals.
This is probably in response to the fact that synthetic antioxidants are in decline whereas the natural antioxidants such as vitamins, C and E and the various tocopherols and carotenoids are increasing in prominence due to them being more readily accepted by the consumer than the synthetics such as butylhydroxytoluene(BHT). These antioxidants are commonly used as food preservatives, in that they slow down the oxidation of foodstuffs, and people are increasingly feeling that natural products are preferable for this application than synthetic.
Guarana seeds have been found to be exceptionally high in proanthocyanadins with powerful antioxidant properties. They are fatal to free radicals and help to prevent cardiac disease and to improve cellular activity. They also display antimicrobial and antifungal activity. Chemically, they consist of up to 60% starch, pectins, saponins, proteins, and the aforementioned caffeine (3% - 5%). The guarana paste can contain up to 7% caffeine that can be dangerous to those with cardiac problems.
Guarana also contains tannins at levels of up to 12%, including catechin and some proanthocyanadins. The astringency of these tannins represents a problem to their use in the beverage and food industry, although the substance is regarded as safe by the FDA. They have little if any nutritional value and can react with Alkaloid and proteins to form unwanted complexes. Were it not for tannins guarana would be more acceptable to the food industry.
However, it is for their energy-boosting properties that the guarana berries and seeds are most prized by many. The fact they it has been traditionally used as a stimulant and aphrodisiac indicates that there is something behind these claims. Studies on mice, hamsters and other animals have supported these effects. It has been found to posses the two desirable properties (to some) of stimulating the nervous system and curbing the appetite.
Consequently, it is used in diet and weight loss pills, and also to maintain high energy levels. In fact weight loss pills are used by many people to maintain their energy levels while not eating. This is a definite bonus to those that want to lose weight, but dislike the lethargy that a strict diet can cause.
There is a downside to that of course, and that is insomnia and an increased heartbeat, and also nervousness and feeling 'on edge'. Once people stop using guarana they suffer withdrawal symptoms such as nervousness, irritability and headaches.
The upshot is that it is basically the high caffeine content of guarana that allows its use as a stimulant that can boost not only energy, but also reduce appetite and act as an effective weight loss supplement. However, used excessively it can lead to nervousness and while it is included as an ingredient in many foods and drinks, you should be careful when using it as an energizing supplement if you have any heart problems at all.
Otherwise, guarana is used to energize the body naturally, and is not only very commonly used for this purpose in South America, but also increasingly so in the USA and elsewhere with some very good results.
November 12, 2008 09:51 AM
Gymnema sylvestre is found naturally in central and southern India, where it has been used in traditional Indian medicine for almost two thousand years. It is known as 'gurmar' in ancient Indian texts, a word meaning 'sugar destroyer', which gives an indication of its uses in medicine.
It is used to reduce the absorption of glucose into the body, and also reduce the sweetness of foods, both of which are desirable for those wishing to lose weight and to reduce the level of sugar in their blood. It was used for this purpose in Ayurvedic medicine, subjects being given the leaves to chew. As with many other ancient Ayurvedic remedies, this use of gymnema sylvestre has passed into modern times, and has sound scientific basis. First, however a bit more about the plant itself.
It is found predominantly in the Western Ghats, and also to the west of the mountains, around coastal Goa. It is a vinous plant that climbs on other bushes and trees, known in Sanskrit as Meshasringa, or ram's horn after the shape of the leaves from which the supplement is extracted. For what it's worth, the official name seems a mix of Greek and Latin (gymnos(Gr) - naked and Silva (L)- forest) for naked forest. That, however, is irrelevant to its uses, so let's have a look at the science involved and the active ingredients in the plant.
The main constituents are terpenoid saponins known as gymnemic acids, so one can assume that they were first found in this plant. They are glycosides, including hodulcine and ziziphin, which act as sweetness inhibitors so that there is no sweet taste in anything that is sweetened by sucrose. There are over 20 types of gymnemic acid in the leaves, of which the strongest, Gymnemic Acid 1, can suppress the sweetness even of artificial sweeteners such as aspartame.
These are not irreversible effects, and last only about 10 minutes, after which normal sweetness is detectable by your tongue. During the active period, however, a solution of normal sugar will taste like ordinary unsweetened water. However, is this just a matter of taste, or does it affect the sugar itself?
Studies have shown that animals fed the leaves of Gymnema sylvestre develop hypoglycemia, probably because it stimulates the pancreas to generate insulin that reduces the level of sugar in the blood. Further studies have shown the presence in the leaves of a number of types of acylated derivatives of deacylgymnemic acid. There are well over a dozen types of saponins known to be contained within the leaves.
Other chemicals found include anthraquinones, flavanoids, chlorophylls, querticol, phytin, a number of glycosides and anthraquinones. The bush also contains Alkaloids, although these are constituents in most plants used in ancient remedies. This is by no means all of the chemicals discovered, and many of the minor benefits of using it could be due to the minor constituents of this amazing little leaf.
A study of the above constituents will reveal a few antioxidants, and it is no surprise that the extract from Gymnema sylvestre also possesses anti-inflammatory properties. Gymnemic acid is believed to have a similar chemical structure to saccharose, and the plant extracts can be used not only to reduce a craving for sugar, but also to treat digestive problems and high cholesterol levels. So what scientific evidence is there other than the obvious effects reported by those that use it?
A study in the UK in 2005 found that an aqueous extract of Gymnema sylvestre caused the secretion of calcium and insulin from mouse and human cells to be increased at a specific concentration without affecting the cellular function. This means that the supplement can be used to stimulate the secretion of insulin with people with Type 2 diabetes without otherwise affecting health. Its usefulness to diabetics is obvious, but there are other health benefits to those that are not diabetic.
Anything that modulates a sweet tooth must be of use to those seeking to lose weight, particularly if they feel the need for sweet foods. In fact Gymnema tends to reduce food cravings for carbohydrates and sweets, and can be used by those seeking a natural means of curbing their appetite for sweet and sugary foods. Because excess weight can lead to diabetes,
Although there have been many discussions about the biochemical mechanism of the gymnemic acids in this effect on taste, recent evidence suggests that the phytochemicals act on both your taste buds and on those parts of the intestine responsible for absorbing nutrients from digested foods.
Not only that, but studies have also indicated that Gymnema sylvestre removes the bitterness of acerbic chemicals such as quinine in the same way that it removes the sweetness form cakes and candies, and if you drank tonic water it would taste just like water. On the other hand, if you ate an orange, you would taste the acidity but not the sweetness.
The way to use this remarkable supplement is to follow the instructions, and within about a week you will be able to control your appetite much better, and any cravings for carbohydrates you previously had will be much reduced. After a month or so, you will notice an accelerated rate of weight loss if you had been overweight, and diabetics will find a significant reduction on blood sugar between insulin shots.
Gymnema sylvestre can take care of any sugar or carbohydrate cravings, and is of significant use to the overweight, obese or to diabetics, and the mechanism by which it works has now been all but understood, although there are still some biochemical secrets that this amazing plant has yet to reveal. This amazing herb can be found at your local or internet vitamin store.
Una de Gato (Cat’s Claw)
April 26, 2008 09:36 AM
Una de Gato, otherwise known as cat’s claw, is properly Unicaria tomentosa. It has been used as an herbal medicine for at least two thousand years by the people of Central and South America who gave it the name vilcacora.
It grows in jungle areas and rainforest in South America and Asia, and gets its name from the small claw-like thorns at the base of the leaves. One of the environmental benefits of the Una de Gato is that when it is harvested at three feet above the ground, it grows back to its full size of up to 100 feet within a few years when it can be harvested again to three feet. Cat’s claw has been given dietary supplement status by the FDA.
The Peruvian Asháninka tribe has used the plant as a contraceptive and for the treatment of rheumatic conditions, diabetes, acne, diarrhea, cancer, urinary tract diseases and as an anti-inflammatory, and many of the studies of cat’s claw have centered on this tribe. The studies quickly showed the active ingredients to be Alkaloids, both tertracyclic oxindole Alkaloids and pentacyclic Alkaloids that have been found both in the bark and in the root.
The extract is obtained by boiling both the inner part of the bark and the root, each of which differs in concentration of the various Alkaloids. The root is believed to better for its anti-inflammatory powers due to the quinovic acid glycoside it contains, although the relative concentrations of the various Alkaloids can vary according to the time of year and to the chemotype of the plant.
Cat’s Claw comes in two chemotypes, each of which differs in the relative concentrations of the two different Alkaloid types. One predominates in the pentacyclic Alkaloids that strengthen the immune system, and the other chemotype in the tetracyclic Alkaloids that counter that effect and reduce the speed and strength of the contractions of the heart. It is not possible to tell which chemotype a particular plant is until it has been chemically tested. They look exactly the same and it is possible for both to grow sided by side. However, the root is generally richer in Alkaloids, and sells at about twice the price of the bark. Alkaloids are not the only active ingredients in Una de Gato, and it also contains tannins and phytochemicals that have an antioxidant effect and are useful free radical scavengers. They have been studied for their effects in the treatment of HIV and cancer, though mainly due to the glycoside content that will be discussed shortly. The National cancer Institute has confirmed some anti-cancer properties of quinovic glycosides derived from cat’s claw.
The four pentacyclic Alkaloids have been found to have a boosting effect on the human immune system, which it does by enhancing the ability of the white blood cells and macrophages to digest and kill off foreign organisms and debris in tissue and the bloodstream. The inference is that the herb is able to be used to treat a wide variety of infectious diseases, including many immune and autoimmune conditions including AIDS. The results with AIDs are inconclusive, although one particular study showed that cat’s claw produced accelerated healing of cold sores and genital herpes (herpes simplex virus) and shingles (caused by herpes zoster virus). Although the evidence is slight, there are indications of its possible use in treating viral conditions.
It is used in homeopathy for the treatment of a number of digestive ailments, such as Crohn’s disease, leaky bowel syndrome, colitis, gastritis and gastric ulcers among others. It is also used in the treatment of inflammatory conditions such as arthritis, rheumatism and some conditions of the prostate gland.
The tertracyclic indole Alkaloids that appear to counter the immune-boosting properties of their pentacyclic cousins include rhynchophylline, hirsutine, and mitraphylline. Rhynchophylline prevents blood clots in the veins and arteries by reducing the formation of platelets, and can dilate the peripheral blood vessels of the hands and feet. It can also lower blood cholesterol levels and reduce the heart rate. Due to this effect on blood vessels, it is though to be able to improve the circulation in the brain and be a useful treatment for Alzheimer’s sufferers. Hirsutine inhibits contractions of the smooth muscle of the bladder, and so finds uses in the treatment of urinary incontinence.
The pentacyclic Alkaloids pteropodine and isopteropodine are believed to have important properties beyond their phagocytosis effect on the immune system. It has been reported that they have an effect on the 5-HT(2) receptors in the brain. These neurotransmitters are used as targets for many drugs used to treat a variety of conditions such as depression, eating disorders and anxiety, and such Alkaloids have a positive modulating effect on them.
The anti-inflammatory properties of cat’s claw are largely due to the very potent quinovic acid glycosides previously referred to. These have been known about only recently, and they are thought to work synergistically to reduce the tissue swelling (edema) associated with the immune system’s inflammatory reaction. Although this is believed to be largely due to the glycosides, three of the Alkaloids also possess anti-inflammatory properties. This property provides the scientific background for the traditional use of Una de Gato for rheumatism and arthritis, both inflammatory conditions. Many of the digestive conditions for which the plant has traditionally used are also inflammatory in nature.
A threat to cat’s claw is the destruction of the Peruvian rainforest, although not as much as a threat as the destruction of the plant itself. Cat’s claw has reached levels of popularity so high that it is in danger of extinction due to improper harvesting. New laws being enacted by the Peruvian government should help to protect the plant, and to promote its harvesting over cocoa.
When buying cat’s claw, make sure that it is the Uncaria tomentosa form you are purchasing since there is another type, Uncaria Guianensis that contains different Alkaloids and is not as potent as the real Una de Gato. Also beware of a shrub known as cat’s claw acacia, grown in Mexico and the southwest USA, since it contains cyanide derivatives and could be very dangerous if taken by mouth.
How to Manage Migraines Naturally: Magnesium - Feverfew - Butterbur - Ginger
December 21, 2007 10:41 AM
Before you can understand how to manage migraines naturally, it is necessary to understand exactly what they are and how certain treatments could work. It is not generally known that the word ‘migraine’ means ‘half the head’ because it frequently hurts only on the right or the left of the head of sufferer. Some people with migraines do feel pain on both sides at once, although this is not generally the case.
A migraine occurs in stages which are activated by fluctuations in the hormone content of the blood. The ‘aura’, when you see spots and flashing lights in front of your eyes, is the first stage of a migraine attack, and during this time the blood vessels in your neck and head are contracting. You could also find it difficult to concentrate and your fingers could feel cold. At this point they do not have the headache that starts when the blood vessels begin to dilate.
Rather than the contracted blood vessels slowly returning to normal, your hormones have an excessively strong reaction, and cause them to dilate rapidly and become much wider than they should be leading to a severe headache due to pressure on the nerves. Different hormones can be involves with each attack, and the range of effective natural treatments reflect this fact. During this period, your brain could swell slightly, your muscles can tense up and other things can happen to the chemical and hormonal balance of your body. That is why some herbal treatments work for some but not for others, and different people find different treatments effective for them. What works for you might not work for somebody else if their migraine has a different cause. Basically, though, migraines occur in two phases, one being associated with an excess of hormones and the other with a shortage.
It is not easy to live with a migraine since it can be completely debilitating. Some just have a severe headache, while others are affected for days at a time. The headache can become before and after the onset of the shimmering lights and other optical effects that are generated by the brain. It would certainly be useful if those prone to migraines had one or more of the possible natural remedies to hand since there is rarely time to seek to seek professional medical help once the migraine begins, and through the use of natural remedies a potentially bad attack could be nipped in the bud, and at least its effect on you reduced.
Magnesium is common in green leafy vegetables such as spinach and cabbage, whole grains, nuts and seeds. It is an essential mineral for human biochemistry, and is also needed with calcium for healthy bone development and maintenance.
Magnesium is a muscle relaxant, and relaxes the muscles of the blood vessels helping them to relax their dilatancy that cause the migraine pain. It is also useful to help the immune function, reduces blood pressure (by the same blood vessel relaxing mechanism) and also the rhythm of your heart. Magnesium therefore provides you with many health benefits, and though the western diet is not generally deficient in magnesium, some areas can be and a magnesium-containing supplement will not do you harm.
However, particularly high dose of magnesium can lead to nausea, diarrhea, low blood pressure and many other unpleasant side effects, so do not take more than the RDA (recommended daily allowance) in your supplement. Many studies have confirmed its effectiveness in reducing the symptoms of migraine, but not all studies have been successful. However, the condition is so debilitating to so many people, that it should be tried although not in excess. Make sure, however, that your doctor is informed since it could interfere with other medication you are taking for your migraine.
Riboflavin, vitamin B-2, is also believed to useful in reducing the duration and frequency of migraine attacks, working in much the same way as magnesium. It is known that there are many cases of people who suffer from vitamin B-2 deficiency also suffering from migraines, and a riboflavin supplement is also worth trying if you are a consistent victim of this condition.
Feverfew is the best known of the herbal remedies for migraine, and has been used for centuries in the treatment of fevers, headache, migraine and other painful conditions such as arthritis. The active ingredient is parthenolide, an anti-inflammatory that is also an anti-hyperalgesic, and that would explain its effect on reducing the pain. It also blocks lipolysaccharide-induced osteolysis by suppressing the activity of a eukaryotic transcription factor protein known as NF-kappaB that can cause a number of immune response problems, including inflammatory conditions such as arthritis, hence its use to relieve that condition.
Its effect on migraines could be explained by this activity in repressing the inflammatory response to certain stimuli that could be brought about by hormonal activity. Because it must be taken for a few weeks before the actual problem arises in order to be effective against it, feverfew is not effective to treat an existing attack, but to prevent future attacks. Double blind studies have proved its effectiveness in many tests, but not in all. However, if you take feverfew as a regular supplement in you diet, you might never have to try magnesium or vitamin B-2 supplements.
Some people swear by the leaves of feverfew, eating one per day which is easy way to take it. It is important, however, that you do so regularly, since it can take for up to 6 – 8 weeks for you to notice a reduction in your attacks. Don’t give up after 5 or 6 weeks, but continue, since the results will be well worth it. If you stop for a week or two you will have to start all over again. You might get a sore mouth and perhaps mouth ulcers to start with, but these will eventually go once your body is used to it.
You are probably best not to take if you are pregnant since it could cause you to abort. Otherwise, however, it has been shown to be effective in many severe cases. Feverfew is bitter, and can be used as a tea with other herbs, such as rosemary, lavender and sage. If you are taking warfarin, aspirin or other blood-thinning drugs, see your doctor first, and the same is true of NSAIDs (non-steroidal anti-inflammatory drugs). If you are taking these for arthritis, the feverfew itself might be more effective!
If you are taking feverfew as a supplement using commercially available dried leaf then the recommended dosage is around 125mg of the dried leaf. It should contain at least 0.2% of parthenolide (0.25mg/daily), although other studies have indicated that a total of 0.7 mg parthenolide a day should be taken (100mg at 0.7%). Parthenolide is unstable so don’t take it after its sell by or best by date.
Butterbur is also useful in the treatment of migraines. The active ingredient here is petasin, a sesquiterpene ester that also has anti-inflammatory properties, all though it works in a different manner to feverfew. Here, it inhibits the activities of leukotriene generation in neutrophils and eosinophils, which indicates that it also possesses anti-allergenic properties that could help asthmatics that also suffer from migraines. It does not prevent the release of histamine, but does appear to reduce smooth muscle spasm.
You should never take the raw herb, only the extract, because it contains Alkaloids that can harm you. The butterbur extract, however, is a perfectly safe supplement and found effective by many people in the treatment of migraine.
If your migraine is at the front of the head, then you should try ginger. Unlike feverfew, ginger works on a migraine as it is occurring, and improvement can be achieved for a bad migraine within half an hour. In fact if, like many people, you can feel a migraine coming on, half a teaspoon of freshly ground ginger can stop the pain before it starts.
Many herbal treatments for migraine include a combination of some of the above remedies, and many people swear by them. However, migraine treatment is very personal, and you should use what works best for you. If you are also taking other medical treatments however, please make sure that you refer to your physician before using any others, and that includes herbal remedies or supplements.
Power Your Day With Natural Energizer's
December 20, 2007 01:48 PM
If you tend to feel a bit tired now and again, there are plenty of natural energizers that you can use to power your day and provide you with that much needed energy to enable you to get going and keep going.
If you are suffering from chronic fatigue then you need something to get you going, and many people suffering from conditions such as fibromyalgia that can cause severe fatigue and very poor sleeping patters, need an energy booster each morning. It might not help the pain, but it will help their bodies to get moving and provide the energy required for everyday living.
So what substances are available to help you energize yourself for what the day is to bring you? The Chinese use cordyceps, which is type of mushroom that truly could be describes as ‘magic’. It grows on the caterpillars of a type of moth and can improve stamina and endurance, and also regulate sleeping patterns. It is useful for the prevention of depression, and improves the function of your lungs and also of the adrenal function. A low adrenal function can lead to low blood sugar and loss of energy.
Energy is obtained from the cellular mitochondria that metabolize blood glucose into energy. Part of this metabolic process requires the presence of adenosine triphosphate (ATP). Coryceps is known to increase the ATP levels in human cells and so enable the mitochondria to generate more energy. It is used in China by those recovering from surgery or childbirth, and is known to replace the energy lost after heavy exertion.
Its added benefits to those suffering from sexual dysfunction are well known, and it appears to promote stronger blood flow to the extremities of the body. In Chinese medicine it replenishes yin and yang jing and is also a strong antioxidant. It is used extensively by athletes and people who expend a lot of energy while working and exercising.
A magnesium deficiency is rare in the western diet, but it can cause symptoms including fatigue, weakness, irritability, muscle cramps, insomnia stress and appetite loss. Your cardiovascular system is dependent on magnesium for its functioning, and it contributes significant to the strength of the heart muscle contraction and hence the blood flow.
It is also an important component of bone, and during times of stress its stores can be significantly depleted. It is when stressed, then, that most people might benefit from a supplement, and a general energy boosting supplement would also benefit from a small amount of magnesium to replace what is lost through stress. Many people needing a tonic to give them a start to the day might also be under stress for one reason or another, and a magnesium supplement will do them no harm.
D-ribose is found in all living cells. It is an essential building block of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). DNA, of course, is essential to life while RNA is used in DNA replication. Ribose is responsible for providing energy to every cell in your body, and without it you would not exist. Athletes in particular believe that a ribose supplement increases stamina and endurance, and it is used to help speed up recovery of the heart after surgery and after heart attacks.
Ribose seems an excellent candidate to be included in any energizing tonic due both to its ubiquitous presence throughout the body and also because it is a sugar – a monosaccharide in fact, and hence simple and easily absorbed by the body.
Yohimbe is obtained from the bark of a predominantly West African tree, and when ingested it releases an indole Alkaloid called yohimbine into the bloodstream.
Yohimbine is a vasodilator, which means that it widens the blood vessels allowing a greater flow of blood to the extremities. This is one reason why it is also prized by those suffering from erectile dysfunction although it also claimed to be an aphrodisiac. However, as an energizer it is likely the increased blood flow that provides a greater supply of oxygen to the muscles that is the most important property. There are also several more Alkaloids contained in yohimbe bark that likely have an effect on its energy enhancing effects on the body.
Guarana is extracted from the seeds of the guarana shrub, native to South America, and Brazil in particular. The Amazonian natives use it in their food and drinks to improve their alertness and energy and its main benefits likely come from its caffeine content. This is about twice that of coffee beans, and it should therefore be used with caution.
An excess of caffeine can cause restlessness, tension and nervousness due both to the caffeine content (xanthines), and that of other Alkaloids such as theophylline and theobromine. They not only enhance your alertness and energy levels but suppress appetite and increase your metabolic rate that results in an increased need for energy providing foods such as sugars. However, guarana is used by those needing a boost and makes a good energizer for those that find it difficult to keep both physically and mentally active throughout the day.
Bee products provide sugars in a natural form and are excellent and natural energizers for your whole body. Whether you use royal jelly, honey or any other of the bee products available as supplements, they will not only increase your energy levels but also provide you with many other health benefits.
From treating athlete’s foot to healing wounds and alleviating stomach ulcers, honey has many medicinal uses. It is an antioxidant and antiseptic, and can heal you of many conditions from head to toe, inside and out. Bee products are a must in any restorative or energizing tonic and are completely safe with no known side effects.
Each of the above six substances has its place as a natural energizer, and each could help to power your whole day. Put them together and you have an ultra-powerful mix of natural products that should enable you to meet any physical demands put on you. You are unlikely to come across such a combination of effective substances of course, but should make your choice of tonic from any or some of the above, and you can even use them in combination since they do not appear to interact with each other.
A Periwinkle Extract Vinpocetine May Promote Cerebral Blood Flow
December 01, 2007 09:05 AM
Periwinkles form the plant genus Vinca, of which the lesser periwinkle and the greater periwinkle are the two members. They are also a form of dogbane, known for its Alkaloid properties. Periwinkles are of interest to the medical profession due to their biosynthesis of a number of Alkaloids that are used to protect themselves from bacteria and are also toxic to the herbivores that would otherwise eat them.
Many other plants produce Alkaloids, perhaps the best known being poppy, that produces the Alkaloid opium that is the precursor to heroin. The Alkaloids of the periwinkle, however, have a much more beneficial use for mankind in their action on certain types of cancer such as Hodgkin’s disease, and also on the flow of blood to the brain.
The components of the periwinkle include vinblastine, which is used in the treatment of Hodgkin’s lymphoma, and it is the only plant known to produce the Alkaloid, although only in very small quantities after synthetic seeding. This involves introducing modified tryptamines to the plant so that they produce the desired Alkaloid, although only in quantities of 0.002% of the weight of the plant. Although small, this is still less expensive that synthesizing the Alkaloid in a chemical plant rather than a biological one!
Chemists are now seeking more readily synthesizable alternative forms of the Alkaloid that have the same effect, again using the periwinkle as a botanical chemical factory to provide them with a lead as to possible synthetic routes. However, it is for the application of another Alkaloid of this amazing little plant that we are more concerned with here.
In addition to vinblastine, the periwinkle produces the Alkaloid vincamine, a type of tryptamine that can be extracted from the leaves of the lesser periwinkle, the Vinca minor. This periwinkle has been used through the ages as an invigorating tonic and as an astringent to treat bleeding gums and sores in the mouth. Vincamine promotes the aerobic glycolysis that is essential to cerebral health.
Normal glycolysis, or the conversion of glucose to energy in the mitochondria of the cells of the body, occurs best in the absence of oxygen (anaerobic glycolysis). However, the brain produces up to and over 90% more energy through aerobic glycolysis in the presence of oxygen than through anaerobic. Hence one of the needs for such a rich supply of oxygenated blood being needed by the brain. As people grow older, or their brain tissue becomes damaged, then the supply of blood can be reduced and more and more anaerobic glycolysis is switched on. This results in an increasing loss of brain energy and hence brain function. Vincamine can reverse this effect, or at least maintain the status quo, and so enable people to maintain their brain function for longer.
It is also what is known as a vasodilator, and dilates the blood vessels in the brain allowing a greater blood flow. It is known to be beneficial in relation to tasks requiring focused concentration such as mathematical problem solving, and has also been found effective in the treatment of people with poor memory.
Vinpocetine (ethyl apovincaminate) is a derivative of vincamine, obtained by slightly modifying the molecule to produce a commercial form of the Alkaloid. This possesses all of the beneficial effects of its precursor, including its positive effects on memory, believed to be due to the stimulation of serotonin production that improves the rate at which the brain can process information. Tinnitus, or ringing in the ears that has severely reduced the quality of life of so many people, can also be treated with vinpotecine.
Its vascodilation effect is thought to be through its action as a phosphodeaterase 1 (PDE1) inhibitor that results in an improvement in the plasticity of neurons. The mechanism is complex, but the end result is an improvement in the cognitive abilities of the subject. This is supplemented by the effect of vinpocetine on the calcium levels in the blood vessels. This renders them more plastic in much the same way that some anti-hypertension treatments work to reduce blood pressure by increasing the plasticity of the blood vessels by modification of their calcium levels. It can also reduce the viscosity of the blood through its action on the “stickiness” of leucocytes and so allow the blood to run more freely through the capillaries of the brain.
These effects have been demonstrated through double blind studies, and there is little doubt that vinpocetine helps to maintain a healthy cerebral circulation. So let’s have a recap on its various effects, and then finish with a summary of the conditions that the Alkaloid can be used to treat or improve. The theory and biochemistry behind these effects is known, but is complex, but here are the major actions:
a) It improves blood flow by modifying the calcium content of the blood vessels and so improves their elasticity, hence allowing a freer movement of blood. In effect it helps the blood vessels to dilate easier.
b) It inhibits the enzyme PDE1 and by doing so helps to restore the elasticity of neurons in aging brain cells, allowing them to relax more and operate more effectively.
c) It promotes aerobic glycolysis, and so the rate at which the mitochondria of brain cells produce ATP (adenosine triphosphate) that is the chemical manifestation of energy.
d) It helps to maintain a good supply of glucose and oxygen in the brain to allow (c) to occur.
Not all of these may be separate effects, but the outcome is an improvement in conditions such as short term memory loss, dementia and other conditions associated with a reduction in the blood supply to the brain including Menière’s syndrome and vertigo. There is also evidence that it helps with hearing problems, macular degeneration of the eye, and fatigue.
It is a supplement that should be taken by the elderly to help with age-related memory problems, but has also been found to be beneficial in normal healthy people. The periwinkle extract Vinpocetine has been shown to have benefits, largely through an increase in the blood flow to the brain, and will be of use to anybody suffering from conditions that can be related to a deficiency in their cerebral blood supply.
Is Maca a Magic Root?
November 10, 2007 02:58 PM
Maca is packed with nutrients; loaded with vitamins and minerals to help fuel brain function and ease hormone irregularities as well as nourish the body.
Maca is an Adaptogen used for Centuries
November 10, 2007 02:35 PM
Maca has been used for centuries in South American and studied for years by a Dr. Hans Seyle, a Nobel Prize winner on General Adaptation syndrome. The highlanders who live in the Andes Mountains use maca to help them survive and thrive at 14000 to 18000 feet above sea level. Oxygen levels are low at this altitude and maca helps oxygenate the blood. Maca has over 60 phytonutrients to help the body adapt to stress. The unique Alkaloids increase the body’s endocrine and immune function.
Maca contains biological active components that spur an aphrodisiac and libido enhancing effect on the body for both men and women. Today’s herbalists suggest maca for a wide range of usages such as hormonal imbalances, PMS, hot flashes, depression and night sweats, and vaginal dryness. Some herbalists recommend maca for chronic fatigue syndrome, adrenal dysfunction, anemia, tuberculosis, and stomach cancer. All would agree that maca extract can be used as an endocrine balancer and aid in mental clarity.
With all the benefits of maca being discovered, why not give maca a try for your self?
Increase Absorption Of Your Discount Vitamins With Bioperine
November 02, 2007 04:54 PM
In order to understand how you increase absorption of your discount vitamins with Bioperine, it is necessary to understand the metabolic process of thermogenesis. First, however, let’s have a look at what Bioperine is and where it comes from.
Bioperine is obtained from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) of which it is a patented standardized extract. These peppers contain the Alkaloid piperine, and the extract contains 95% piperine. The plants are grown in the ideal damp soil in regions of Southern India where the earth is rich in nutrients. The barriers are harvested just before ripening, and then dried in the hot sun before the extraction process is started. Piperine has many uses from flavoring to fly killer, but people have been using it for centuries to heal wounds though this is apparently unconnected with the use to which the extract is put.
It has recently been found to help increase the absorption of a number of discount vitamins and minerals, including Vitamin B, beta-carotene, and selenium, by increasing the thermogenic activity of the body. Thermogenesis is one of the metabolic processes of the body that takes place within our cells whereby glucose is converted to energy, but at an accelerated metabolic rate. It is the rise in the metabolic rate that is referred to as thermogenesis.
When you eat food, or take supplements, the metabolism increases above the normal rate, the amount of increase depending upon the type on nutrient taken. Fats will increase your metabolism at a lower rate than proteins will, for example, since more energy is needed to break down proteins than for fats. Another substance that stimulates thermogenesis is piperine. It does so by utilizing the biochemistry of the body so that the chemicals needed for thermogenesis are made available.
Piperine triggers the release of compounds known as catecholamines, hormones that in turn stimulate the thermogenetic process. However, this occurs over a short period of time, so the nutrients that are needed should be present in the gut as well since the window of absorption is very narrow. The substance also modifies the epithelial cell wall of the intestine to make it easier for the nutrients to be absorbed into the bloodstream, and it also gives amino acids a kick to get moving to the cells in which they are required.
Bioperine, then, not only sets off the metabolic changes that demand vitamins and other nutrients and enzymes, but also improves the conditions in your intestines so that these nutrients can more easily get to where they are needed. Basically, what Bioperine does is to cause the intestinal wall to become more permeable to nutrients, so that vitamins and drugs are not degraded when passing through the intestinal wall to the bloodstream. This improves digestion and absorption of minerals and vitamins, in addition to protein supplements frequently used in weight loss diets.
Bioperine starts by generating a need for nutrition and then increase the bioavailability of the nutrients provided to meet that need. However, due to the short window of absorption that piperine generates, the vitamins and minerals you want absorbed should be co-administered with the Bioperine so that they are in place ready to be absorbed at exactly the right time.
There have been several studies carried on the efficiency with which piperine achieves this. The absorption of three different types of nutrients has been measured with and without Bioperine. These were beta-carotene, a fat soluble vitamin, vitamin B-6, a water soluble vitamin, and also a mineral, selenium which was provided as selenomethionine. The absorption of these by the digestive system was measured by detecting them before and after in the blood, and were found to increase considerably when taken along with Bioperine, but not so with the control group without it.
Measured increases were a 60% increase in beta-carotene, similar to that of vitamin B-6, and was 30% in selenium. The tests used a 5 mg dose of the Bioperine. Other studies have indicated an increase in the absorption of Coenzyme Q-10 of between 30% - 200%. This is the only piperine based product that has been patented for its effect in increasing the absorption of nutrients into the body, and also the only piperine based product to undergo such tests in the U.S. to substantiate its claims and prove its safety for use.
The black pepper itself is a common household spice, and has been used in India for its medicinal properties for centuries. It is mentioned in the practice of Ayurveda and its concentration on the function of the digestive tract in human health. Many of its formulas contain black pepper amongst their ingredients. The bioavailability of nutrients is a significant factor in the health of any specific population, and the exponents of Ayurveda overcame this problem, by chance or design, six millennia ago. It has been demonstrated time and time again that diet is not the factor of importance in nutrition, but how much of that diet is absorbed through the intestines.
This is yet another example of the medicines of our ancestors being shown to have a solid scientific basis, and perhaps we should pay more attention to those others that are disregarded by modern science. It could be that we have only scratched the surface of understanding human metabolism and biochemistry, and that there is much left to learn. Ancient wisdom should never be disregarded.
Bioperine is also available in many supplement mixtures so that it is taken at the same time as the relevant vitamins and minerals. The recommended dosage is from 1 mg – 5 mg from 2 – 3 times daily. It takes around 2 – 5 mg of Bioperine to provide sufficient enhancement of absorption of the nutrients that are taken with it. Keep in mind that the nutrients are best taken at the same time, and that taking the extract itself will simple increase the absorption of any nutrients that are in the intestine at that time. Bioperine can be purchased at your local or internet vitamin store.
Exotic Herbs From The Amazon Basin
June 22, 2007 05:07 PM
Although many traditional herbal medicines have yet to find complete scientific corroboration in the West, it follows logically that people wouldn't use an herbal product for centuries if it didn't work.
Many of the popular herbs we all recognize as having great health benefits were only recently considered pretty exotic. Even green tea - a staple in China for centuries -has only lately gone main stream.
So it will likely be with herbs from the Amazon basin and its environs. The Amazon basin is one of the most bountiful environments on the planet. Explorers and botanists from the West have looked to this region for generations for the "next big thing." Of course, in many cases, the "next big thing" has already been in use for centuries.
In this issue of Ask the Medicine Hunter, we're going to look at some energizing and life- stimulating herbs that also happen to have great antioxidant properties, too. Best yet, many of them are available to us here from companies that practice fair trade policies.
Let's take a look at some of the herbal powerhouses coming out of the Amazon (and its nearby neighborhoods):
Maca (Lepidium meyenii) has been cultivated for a long time at least 2000 years. Related to brassica family plants like radishes, mustard and cabbage, its foliage does actually look somewhat radish-like, but grows close to the ground.
Maca is cultivated by the Andean people in Peru's central highlands, and contains a plethora of beneficial compounds that enhance overall health and vitality. The tradition of cultivating maca is an old one some strains have been found in Incan sites that date from 1600 B.C. During early European colonization, maca was used by the local native culture as a form of currency, much of the way cocoa was used by the Aztecs, further north in pre-Columbian Mexico.
Maca thrives in high altitudes - between 10,000 and 16,000 feet. The harsher the conditions, the better it grows, or so it seems. In fact, efforts to grow the plant in Central Europe haven't been as successful - maca seems to enjoy its home turf the best. In Peru, maca is a popular and beloved nutrient-packed superfood, and is commonly powdered and mixed into drinks at roadside stands throughout the Andes.
Q. I've heard of maca being used for healthy libido - are there any other benefits?
A. Maca is a natural energizer, and although it is recognized for it's libido enhancing abilities, it has other uses, too, acting as an adaptogen - similar to rhodiola or ginseng. In fact, in South America, maca is known as "Peruvian Ginseng." Though maca is not ginseng at all, some of the benefits of both plants are similar.
In any event, maca is recommended for boosting the immune system, menopause support, and hormonal balance in general. For daily use, maca is most recognized as a great source of energy and all-day endurance. Alkaloids from maca root may be partially responsible for both maca's energizing and libido boost. Research shows that maca affects the hypothalamic-pituitary (HPA) axis - boosting energy and overall aphrodisiac prowess in men and women. Maca contains novel compounds called macamides and macaenes, which have been proven in animal studies to significantly enhance energy, stamina and sexual function reasons people have been so consuming maca for 2000 years.
There are other serious reasons why maca is such an excellent plant. One group of compounds in maca is the isothiocyanates-aromatics constituents that are responsible for the "hotness" of mustards and radishes - fellow members of the brassica family. Isothiocyanates from other members of the brassica family may reduce the risk of breast and stomach cancer. Although the same constituents specifically from maca haven't beentested, it's plausible that they could have the same effects.
Q. I've heard a little about guarana extracts - is it just caffeine?
A. Guarana is widely loved for its mild stimulating effect, which is due to caffeine. But this is by no means this Amazonian herb's sole beneficial compound. Guarana (Paullinia cupana) is so logically ingrained in the culture of Brazil that it's practically a rival (actually out-sells) Coca-Cola in its soft-drink form. Like many other indigenous herbs, guarana was in use locally well before European settlement. Its Latin name comes fromthe German botanist C.F. Paullini, who first encountered the herb in the 1700s. This evergreen vine typically climbs fairly far up the Brazilian forest trees. The seed is the part that gets used. In one clinical study, guarana boosted the memory alertness of participants, even when the caffeine level per dose was a low 9 mg., as compared with approximately 100 mg for a cup of coffee. This effect suggests that other agents than caffeine contribute to a feeling of well being.
Guarana also contains powerful antioxidants including catechin, epicatechin and proanthocyanidins, which protect cells against destruction from free radicals, and impart benefits to the body's tissues and blood. The small seed of this plant is powerful in its health benefits.
Catuaba (Erythroxylum catuaba) is a common tree found in South America from Brazil to Peru, in the same genus as the coca plant. Catuaba contains components known as Alkaloids. These Alkaloids (called catuabine A, B, and C) are probably responsible for themental boost most people get when they take catuabe-based supplements or mixes.
There may be little confusion regarding catuaba, because various species and genus typesuse the common name. As a result, "catuaba" gets bandied around a lot, and one person'scatuaba may not be the next. Read labels carefully. The catuaba I've had the best luck with is Erythroxylum catuaba.
One of my favorite drinks in the world is coffee, and I'm sure at many people reading thisconsider it the essential part of their morning, too.
The part of coffee that we use the most is the seed of the coffee fruit - which appears as a bright, red berry. Most of the time, this fruit is sloughed off and left behind in the process of making coffee - it's really too delicate to last long in hot conditions.
But advances in technology have tapped a previously discarded resource. Though the fruit of coffee is available in any coffee-growing economy, a high antioxidant commercial extract of "coffee cherry" is now available from the fruits of coffee plants in Mexico.
Coffee fruit has many of the attributes of other dark-colored, anthcyanin-rich fruits. Coffee fruit (also referred to as "coffee cherry") appears not to be just another antioxidant, however. Current research on this once-forgotten, former castoff shows impressive abilities to decrease tumor size, and possibly even prevent their formation in the first place. It seems that the elements in coffee berry activate T-lymphocytes in such a way that mammary tumors are shrunk or simply put on hold. It will be fascinating to see how this science plays out.
Muira Puama Bark:
Muira puama (Ptychopetalum olacoides) grows between 15 to 45 feet high. Native to theAmazon basin of Brazil, the dried bark has been used for centuries as a traditional energysupport. Components include beta-sitosterol, campesterol and lupeol.
Muira puama, like other central nervous stimulants has been researched lately for its ability to boost memory retrieval and protect neural (brain) tissue. Who knows? Maybe this traditional ingredient could someday be on the cutting edge of natural medicines fighting Alzheimer's, much the way green tea and turmeric are currently. In one unpublished French study of 262 men with low libido and poor erectile function, 62% experienced significant improvement after taking an extract of Muira puama for two weeks.
Acai (Euterpe acai) berry is a traditional favorite (and readily available) food source for people in the Amazon. The tree is a tall-growing palm with berries that provide - a rich source of anthocyanins, potent purple pigments with extraordinary high antioxidant activity.
Once harvested, acai fruits decay rapidly. As with coffee fruits, special processing is the surest way to make certain the nutrients of acai berry make it to those of us outside the Amazon basin.
However, these wonderful fruits not only fight against free radical damage, but help our natural digestive enzymes and boost natural immune defenses, too. In fact, current research is investigating whether compounds in acai may have a fighting effect on leukemia, too. So far, the results have been very positive.
Look for supplements made using organically-grown, fair trade acai berry. The best companies ensure that the local people harvesting acai and the communities where they live gather more than just short-term benefits. The best companies work not just to provide jobs, but better lives for generations to come.
Q. What is sustainability and fair trade, anyway?
A. Sustainability refers to a set of naturally occurring circumstances, or intentionally designed practices and principles, which ensure that all parts or members of a situation are adequately nourished to promote their healthy continuance. In current parlance, sustainability often refers to practices and programs designed and implemented to keep natural systems healthy and flourishing. Many such programs focus on environmental protection and preservation of traditional cultures. In the world of medicinal plants, sustainable practices include organic agriculture, species management, fair trade, and benefit-sharing programs.
In other words, sustainability pays people fair wages, puts resources back into their communities, and ensures that the resources that benefit us all are going to be around for a long time. It is an earth-friendly, people-friendly concept of commerce that happily, is taking root around the world.
The traditional cultures that use - and have used - these ingredients for generations wouldn't have done so if they hadn't been effective. Fortunately we live in an era when formerly locally-used herbs are now available far beyond their previous range. We are also fortunate to have companies and individuals working hard to make sure that the people who tend and care for these precious resources are paid fairly for their efforts, andthat their families and communities benefit from this commerce as well.
The great thing about using traditional herbs and ingredients that have been gathered in this manner is that you know they'll be around for a long time.
Supreme Court Refused Ephedra Appeal…
May 17, 2007 01:39 PM
Supreme Court Refused Ephedra Appeal…The U.S. Supreme Court on Monday refused to consider an appeal by Nutraceutical International Corporation, which sought to overturn a federal ban on the dietary supplements containing ephedrine Alkaloids. The court’s decision, issued without comment, lets stand a 2005 ruling by a federal appeals court that upheld the Food and Drug Administration’s (FDA) 2004 ban. David Seckman, executive director and CEO of the Natural Products Association commented on the refusal. “Obviously we were concerned about the consequences of the circuit court’s ruling on the risk benefit standard the FDA used in removing ephedra from the market, which is why we filed our amicus brief. As we clearly stated in the brief, we believe congress did not intend for such a standard to be used. But, since the Supreme Court decides to take up only between five and ten percent of cases brought to it, it is not a shock that they’ve decided not to hear it. We should note, however, that the denial of the Nutraceutical petition is not an affirmation by the Supreme Court that they agree with the lower court’s decision,” Seckman said. In April, the Natural Products Association had filed a “friend of the court” or amicus brief with the U.S. Supreme Court that challenged the lower court ruling on the standard used by the FDA to impose a 2004 ban on ephedrine Alkaloids in dietary supplements.
Solaray - Ultimate Nutrition - Actipet Pet supplements - Action Labs - Sunny Greens - Thompson nutritional - Natural Sport - Veg Life Vegan Line - Premier One - NaturalMax - Kal
March 08, 2007 12:27 PM
Revita, the most efficient hair growth stimulating shampoo available in the market is the final result of DS Laboratories efforts on cutting edge research. Revita is a powerful and unique SLS/SLES free combination of active ingredients specially designed to maintain scalp vitality and act on folicle dysfunctions in order to achieve best results in short periods of time. Sodium Lauryl Sulfate and Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers, are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, providing a high quality scalp skin safe shampoo product.
Revita was developed with a cost-no-object approach. Revita’s compounds have been chosen based exclusively on their properties, quality and efficacy (in the opposite of the majority of available products, which are usually developed with production costs in mind). The final result is a very high quality shampoo product with absolutely no equivalent competitor in the market. Revita combines costly first line compounds at high concentrations like Caffeine at 4.0%, Pyrus Malus (Apple) Seed Extract at 1.0% and Spin Traps (SOD Mimic) at 0.1% with other top level ingredients which make Revita a unique product in its class.
To improve the efficacy of this synergic combination, DS Laboratories developed a unique “chemical free” extraction process that keeps original properties and clinical efficacy of final components. Through gentle mechanical compression, Revita’s compounds are obtained as pure and chemically preserved active molecules.
Revita starts acting on your scalp and hair follicle since the first day of use. The time you will need to note the first results will depend of the severity and duration of your hair loss. No matter how long or how intense your hair loss is, using Revita on daily basis will improve the vitality of your scalp, maintaining the quality of your hair and stimulating new hair growth.
Through the synergic interaction of very effective compounds, Revita brings you a highly effective product designed to maintain scalp vitality and act on hair loss. By combining an antioxidant effect, anti-DHT properties, powerful hydrating molecules, hair growth stimulants and structural amino acids, Revita brings you the most effective hair growth stimulating shampoo available.
Apple Polyphenol (procyanidin B2 and C1) - phytochemical concentrate found in the skin of unripe apples that acts as potent antioxidant. It protects cells against free radicals, reactive atoms that contribute to tissue damage in the body. These chemical compounds are being studied extensively in labs around the world for their health effects in major diseases including treatment of hair growth. Studies showed that after sequential use, an increase of almost 80% of hair diameter and an increase in number of total hairs was shown, with no side effects.
In 2000, Japanese researchers presented their findings to the international community on the hair growth effects of apple polyphenols - specifically one known as procyanidin B-2. They identified two successful compounds- one from chardonnay grapes, and one extracted from unripe apples. The procyanidin B-2 fraction clearly outperformed the grape extract. "Procyanidin B-2 purified from apples," stated the research team, "shows the highest activity of more than 300% relative to controls."
In the same year, in a double-blind placebo-controlled trial, nineteen men with male pattern baldness were studied with a daily topical application of a 1% procyanidin B-2 solution, extracted from apples. Ten other balding men served as controls, receiving a placebo solution. After 6 months, the study concluded:
• The increase in number of total hairs and terminal hairs in the procyanidin B-2 group subjects was significantly greater than controls.
• 78.9% of subjects showed an increased mean value of hair diameter.
• "Procyanidin B-2 therapy shows promise as a cure for male pattern baldness."
Following the revelations, an attempt was made to further understand the mechanism by which the remarkable hair growth effects occurred. The results were published in the prestigious British Journal of Dermatology: Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study, Br J Dermatol. 2002 Jan;146(1):41-51. In this study, the researchers concluded that procyanidin B-2 acts to diminish protein kinase C isozymes, which play an important role in the hair growth cycle. Procyanidin B-2 seems to promote hair growth by down regulating PKC in both the anagen (active growth phase) and telogen (resting phase) of the hair follicle. When the anagen phase is prolonged, and the telogen phase is shortened, increased hair growth results.
Two more clinical trials and a total of seven published studies have now confirmed the surprising hair growth-promoting effects of apple procyanidins. Here is a summary of those findings:
• Total Number of Hairs: Significantly Increased
• Total Number of Terminal Hairs: Significantly Greater
• Increase in Hair Diameter: 78.9% Positive • Ratio of Thicker (terminal) Hairs: Significantly Higher
• Hair Follicle Activation: Intensive
In the most exciting development yet, Japanese researchers released a new study late in 2005. Once again, procyanidin therapy was proven successful in regrowing hair in subjects with male pattern baldness. The new study, published in the Journal of Cosmetic Dermatology, confirmed the findings of earlier studies, showing clear improvement in the number of hairs and the density of hairs in the treated area. Building on the success of earlier trials, the study was extended to 12 months in the procyanidin group, and proved that longer term procyanidin therapy was even more successful than prior 4 and 6 month trials.
Cooper Peptides - Cooper Peptides have two main properties: (1) potent tissue protective anti-inflammatory agents that limit oxidative damage after tissue injury, and (2) tissue remodeling activation agents, that is, the processes for removal of damaged protein and scar tissue and their replacement by normal tissue. Studies at numerous universities and research institutes have found copper-peptides to improve hair transplant success, increase hair follicle size, stimulate hair growth and reduce hair loss.
Research scientists at the University of San Francisco Wound Center stumbled upon very interesting results. Their discovery was made while applying a synthetically formulated compound, Copper Peptide, to severe wound areas on several patients. During this process something unusual happened. Not only did the wounds heal about 30 percent faster, but a significant stimulation of the follicular cells occurred. As a side effect, these tripeptide complexes actually grew hair around the wound area.
The discovery was so startling that they then applied the same Copper Peptide complex to a female patient who had suffered roughly 90 percent alopecia (hair loss) for years. After about six months of use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart, the leading authority in Copper Peptide technology, describes it as being like a protein injection to the scalp.
Tests were then conducted with chemotherapy patients and recent hair transplant recipients, all with great success in stimulating newer and stronger hair follicles.
Spin traps – are very special compounds that were originally utilized in measuring free radical activity because they react with free radicals both in vitro and in vivo, producing stable complexes. The most commonly used spin trap and the standard which measures new ones is PBN - alpha-phenyl- N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions. Later it was discovered that these spin traps had powerful free radical quenching abilities in living systems and could treat a variety of conditions. Spin traps could provide unique protection against free radical damage that complements and enhances the activities of the classical antioxidants such as vitamin C and vitamin E.
Spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthases that are implicated in pro-inflammatory disease conditions. A method for ameliorating a cellular dysfunction of a tissue such as the treatment of hair loss and stimulation of hair growth comprises administering a nitroso or nitrone spin trap to the affected tissue. These agents inhibit the reaction of superoxide and nitric oxide to produce peroxinitrite. Scientists discovered that nitrone and nitroso spin traps have properties in the body for ameliorating cellular dysfunction in tissue attributed, in part, to high energy oxygen and hydroxyl free radicals, and enhancing recuperation of the tissue. Alpha-phenyl-N-tert butyl nitrone (PBN) can be administered, for example, as an anti-alopecia agent to stimulate hair growth.
Spin traps can be administered to the skin to be treated, such as the scalp. Depending on the type of hair loss or alopecia being treated and the conditions thereof, the stimulation of hair growth can usually be obtained by topical application, preferably repeated daily application. The utility of topically applied spin traps is not limited thereto, however, and the stimulation of hair growth can include an increased rate of growth, increased hair diameter, follicular neogenesis, and the like; inhibiting hair loss or alopecia from progressing.
Ketoconazole - Topical ketoconazole shows itself to have an anti-DHT binding effect in the scalp. Nevertheless, it is likely that ketoconazole exhibits other methods to its anti-hair-loss effect. One such theory of ketoconazole anti-alopecia effects may be on its activity upon the removal of sebum, a fatty substance that accumulates in the scalp around the hair follicles. In addition, ketoconazole is an antifungal medication and is significant for people combating hair loss since acting as an antifungal agent it reduces scalp irritation caused by fungal colonization or infection. Reduction of the inflammatory process that occurs in male pattern alopecia is crucial.
If we first examine the role of androgens, specifically dihydrotestosterone (DHT), we find that this hormone has been thought to slowly "choke" the growth of the hair follicle by inhibiting the function of an enzyme in the hair follicle called adenylate cyclase. Suffice it to say that when DHT concentrations remain high in the scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus hair (fine, thin peach fuzz). On March 04, 2001, at the American Academy of Dermatology Meeting in Washington DC, scientists presented the findings of a study done on 1% ketoconazole shampoo which had good news for hair loss sufferers. In the study presented, one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using in a double-blind fashion either a 1% ketoconazole shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with ketoconazole (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hairs shed over a 24-hour period was reduced by 16.46% with ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the percentage of hairs in the anagen phase increased by 6.4% and 8.4% respectively during the study.
The results are similar to a previous study done on 2% prescription strength Ketokonazole where it was shown that use of 2% ketoconazol yielded an increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.
Rooibos - Rooibos or Red Bush Tea - a hardy shrub indigenous to the North Western Cape of South Africa – is an exciting new botanical ingredient with potent antioxidant and anti-inflammatory properties well documented in medical literature. In alternative medicine Rooibos is often prescribed for nervous tension, allergies, stomach and digestive problems. Results from an independent study also showed a significant improvement in hair loss. Studies were initiated at an independent laboratory (Dermascan, France) to study the effect of the use of Rooibos in a hair lotion on a group of healthy persons who were suffering from the problem of hair loss. A 90 day trial was conducted comparing a hair lotion containing Rooibos with a placebo lotion.
After 90 days results showed a significant increase of the hair growth in the lotion containing Rooibos compared with the placebo. An increase in the hair growth was observed with 89% of the volunteers with no undesirable reactions (irritation or allergy). The participants were next asked to fill in a questionnaire. When the results were tallied, 67 percent rated their hair loss as zero or low, 78 percent saw a low to medium improvement, 45 percent saw a low to medium regrowth of hair, and 63 percent considered their hair had become smoother and shinier.
Conclusion: results show that most of the volunteers had a remarkable improvement in both the increase of hair growth and the decrease in hair loss.
MSM - Sulphur is present in protein-rich foods containing high levels of the amino acids methionine and cysteine. These foods include meat, fish, legumes, nuts, eggs, and vegetables, especially onions. However, sulphur has recently become a popular nutritional supplement and topical treatment thanks to the discovery of methylsulfonylmethane, or MSM.
The use of MSM as a nutritional supplement and topical application is relatively recent. An American chemist named Robert Herschler, began studying MSM in 1955. However, another man, Dr. Stanley Jacob with Oregon Health Sciences University in Portland, is considered by many to be the father of MSM. Dr. Jacob found that simple marine life like algae and plankton convert inorganic sulphur to organic sulphur compounds. These compounds are known as dimethylsulfonium salts. These salts are transformed into dimethyl sulfide (DMS), which is released into the atmosphere and is converted by ultraviolet light into dimethyl sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by plants that become food for animals and humans. MSM is a white, crystalline powder that is odorless and nearly tasteless. When taken as a dietary supplement, MSM proved to have the same health benefits as DMSO without side-effects such as bad breath, itchy skin, nasal congestion, and shortness of breath. Why does MSM help with the development of stronger hair? Various scientific studies have proven that MSM contributes a definite normalizing effect on body functions. The sulfur normally provided to the body by MSM is required for healthy collagen and keratin which are essential for healthy hair, skin and nails. MSM also has proven antioxidant benefits which can disrupt or alter damaging chain reactions of lipid peroxidation in the cell membranes.
MSM has been widely used as a dietary supplement without any reports of allergy or intolerance related to its use. Supplements of MSM are comfortably assimilated without side effects. There are no known contraindications.
Caffeine 4% - Active caffeine ingredient helps to regulate the effects of testosterone levels. Male pattern baldness is known to occur in individuals with sensitivity to testosterone, causing damage to hair follicles that eventually leads to baldness. Caffeine is a xanthine Alkaloid compound that acts as a stimulant in humans. Caffeine is a central nervous system (CNS) stimulant, having the effect of warding off drowsiness and restoring alertness.
The independent study at the University of Jena used hair samples from the scalps of young men entering into the first stages of hormone-related hair loss. The study relied on a hair organ culture that used four different types of testing samples. The first was a nutrient-based sample, the second a testosterone only sample, the third was a caffeine only sample and the fourth a mixture of caffeine and testosterone.
According to the research, the results showed that the samples containing the caffeine nutrient helped to stave off hair loss and encouraged new hair growth, while the sample that relied on testosterone only led to increased hair loss. But perhaps the most impressive was the testosterone and caffeine sample, which helped to prevent further hair loss.
The results showed that using the caffeine treatment average growth was increased by around 46 per cent and the life cycle of the hair was extended by 37 per cent, when compared to the control study.
Carnitine Tartrate - L-Carnitine, a vitamin-like nutrient, occurs naturally in the human body and is essential for turning fat into energy. Active energy metabolism is an essential prerequisite for the growth of strong and healthy hair. In biological systems ATP acts as the universal energy currency. One of the most potent bio-actives that significantly increases cellular ATP content is carnitine tartrate.
Statistical evaluation demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate, showing that carnitine tartrate is an ideal ingredient for hair care formulations, providing energy for the optimal environment to produce strong and healthy hair. Throughout the test period ATP content within plucked hair follicles was determined twice daily using a commercially available test kit. Statistical evaluation of baseline adjusted values demonstrated a significant increase in ATP equivalents in human hair roots treated with carnitine tartrate. These effects were absent in the placebo group, thus underlining the stimulating activity of carnitine tartrate.
The outstanding bio-activity of carnitine tartrate was furthermore demonstrated in a second study, assessing the effects after a single application of a shampoo formulation supplemented with carnitine tartrate. Again, ATP levels in plucked human hair follicles were significantly increased.
Amino Acids: Ornitine, Taurine, Cysteine - Amino acids are the building blocks of protein, from which hair is created. They are assembled in the correct sequence by stem cells to form keratin, a complex and immensely strong hair protein. Vital amino acids have to be replaced consistently, as damage is accumulated over time. We can replace a combination of these lost amino acids directly into the hair, where they are shown to provide significant tensile benefits to the hair shaft.
Hair is composed primarily of proteins (88%). These proteins are of a hard fibrous type known as keratin. Keratin protein is comprised of what we call "polypeptide chains.” The word, polypeptide, comes from the Greek word "poly" meaning many and "peptos" meaning digested or broken down. In essence, if we break down protein, we have individual amino acids.
Many (poly) amino acids joined together form a "polypeptide chain". Two amino acids are joined together by a "peptide bond", and the correct number of amino acids placed in their correct order will form a specific protein; i.e. keratin, insulin, collagen and so on. The "alpha helix" is the descriptive term given to the polypeptide chain that forms the keratin protein found in human hair. Its structure is a coiled coil. The amino acids link together to form the coil and there are approximately 3.6 amino acids per turn of the helix (coil). Each amino acid is connected together by a "peptide bond". The peptide bond is located between the carbon atom of one amino acid extending to bond with the nitrogen atom of the next amino acid. In many individuals the extremities, including the top of the head, are the most difficult places to maintain blood flow. Follicles which are constantly deprived of blood, and therefore nutrients, cannot produce hair properly. Lack of proper nutrients, amino acids, minerals and vitamins can certainly hamper hair growth.
L-Arginine is a semi-essential amino acid synthesized by the body from L-Ornithine. Arginine + Ornithine support protein synthesis because they are involved in the transport and storage of nitrogen. The usage of taurine corrects the "rigidification" of the connective sheath that surrounds the Pilosebaceous unit and hair follicles, specifically those affected by pattern hair loss. This is a novel and previously undisclosed angle on hair loss treatment that has yet to be touched upon in any of the medical literature or prior publications.
The amino acid, l-cysteine speeds up hair growth and increases hair shaft diameter resulting in fuller hair. L-cysteine has been reported to facilitate longer hair growth, beyond what is genetically programmed. L-cysteine also provides potent antioxidant protection to the hair follicle. Users of topical n-acetyl-cysteine have reported hair regrowth.
Emu Oil - The emu, dromaius nova hollandiae, is a flightless bird part of a group called ratites which also includes the ostrich and the kiwi. Modern Australians learned early on from the Aborigines the many valuable qualities in the emu and its oil. The earliest research studies in emu oil come from Australia, and Australia continues to export emu oil to this day.
In the United States today there is a growing network of research labs interested in emus and their incredible oil. Emu oil is rendered from a thick pad of fat on the back of the bird that was apparently provided by nature to protect the animal from the extreme temperatures in its Australian homeland. Emu oil is deep penetrating and super hydrating to the skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor of Medicine, Physiology, and Dermatology at Boston University School of Medicine conducted a study involving emu oil and hair growth. His study found that there was a 20% increase in growth activity of skin that received emu oil compared to skin that received corn oil. Looking at the hair follicles Dr. Hollick realized they were much more robust, the skin thickness was remarkably increased suggesting that emu oil stimulated skin growth and hair growth. Additionally, the study showed that over 80% of hair follicles that had been "asleep" were woken up, and began growing.
Emu oil is anti-inflammatory, which may be in part why it stimulates hair growth. Emu Oil has also been shown to be a 5 alpha reductase inhibitor in target tissues when topically applied, which likely contributes significantly to its hair growth properties. A third important property of emu oil is that it is bacteriostatic.
Emu Oil contains a multitude of Essential Fatty Acids (EFA) which helps to "feed" the skin. Consumers who suffer from natural forms of baldness have reported hair re-growth. Since Alopecia Areata only suppresses the hair follicle (vs. killing the hair follicle), emu oil may have an effect to assist with hair regrowth.
Biotin – Biotin is a member of the B-vitamin family and a major component in the natural hair manufacturing process -- it is essential to not only grow new hair, but it also plays a major role in the overall health of skin and nails. The beneficial effects of biotin on hair may be linked to its ability to improve the metabolism of scalp oils. Biotin when absorbed by the scalp may promote hair growth and it is able to penetrate the hair shaft making it expand which actually thickens the hair cuticle.
Biotin is used in cell growth, the production of fatty acids, metabolism of fats and amino acids. It plays a role in the Krebs Cycle, which is the process in which energy is released from food. Biotin is so important to hair health, that many dermatologists prescribe biotin supplements to their patients as part of their medical treatment for hair loss.
After applying Revita with a gentle massage, you should leave it on the scalp from 1 – 2 minutes before rinsing. Then repeat and leave on the scalp for 3 – 5 minutes. If desired, follow with a high quality conditioner. For optimal results, Revita should be used at least 5 times per week.
This formulation is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.
Q. Is Revita safe ?
A. Revita primarily contains compounds that are not only safe in topical use, but actually dramatically enhance overall skin health. The other active ingredients such as Ketoconazole have been tested in clinical studies and have been shown safe.
Q: Can I use hair sprays, mousses, gels, etc.?
A: Hair spray, gel, and other styling aids are not recommended since they tend to clog the hair shaft. However, you can use them while using Revita.
Q: Can I have my hair colored or permed while using Revita ?
A: While there is no evidence that coloring or perming hair can lead to or even worsen hair loss, it is generally not recommended for people with hair loss. If you are experiencing hair loss then perming and coloring hair is not recommended. However, this will not interfere with Revita.
Q: What is SLS/SLES free ?
A: SLS means Sodium Lauryl Sulfate and SLES means Sodium Laureth Sulfate, commonly used low cost detergents in shampoos and cleansers. They are linked to skin irritation, skin drying and hair loss due to follicle attack. Revita is Sodium Lauryl Sulfate and Sodium Laureth Sulfate free, and that means that Revita does not irritate you scalp and preserves your hair follicale health.
Q: Can I blow dry my hair after using Revita ?
A: Extreme heat damages the proteins in the hairs making them fragile. Nevertheless, if you need or want to blow dry your hair, you can do it after using Revita.
Q: Who is a candidate for Revita ?
A: Ideal candidate is someone with little hair loss or at the beginning stages of hair loss, since it is much easier to prevent hair loss then to grow new hair. Someone who is concerned with hair loss prevention should start using Revita immediately.
Q: What type of results should I expect with Revita ?
A: When deciding to use Revita, it is important to have realistic expectations. Depending of severity and duration of your hair loss, it could take some time to see hair growth. In fact, during the first 2 weeks of treatment you may actually notice increased hair loss as old hairs are being pushed out and the hair follicles start growing new hair. Do not become alarmed with this and just stick to the treatment.
Q. Does Revita have any systemic side effects ?
A. No, when used as directed, Revita active ingredients have a long history of use both orally and topically.
Q. Does Revita work for women?
A. Yes. In most cases, the cause of hair loss in women is surprisingly similar to men. Fortunately for women, estrogen helps to protect the hair follicle from the destructive effects of DHT. However, many women develop thinning hair and loss due to fluctuation of estrogen levels and/or over production of DHT. Revita can help protect the hair follicle from DHT resulting in a thicker, fuller and healthier hair.
Q. I am using other topical treatments. Can I use Revita at the same time ?
A. Yes. Revita has no side effects and does not cross react with other topical treatments. You can safely opt to use Revita with other products, and we strongly recommend the association with Spectral.DNC for more severe hair loss or Spectral.RS for thinning hair.
Q. Do I need to use Revita for a long time ?
A. Once you have reached the desired results, you should continue to use Revita as your regular shampoo to maintain the revitalized hairs and a healthy scalp.
Q: Is stress a factor in hair loss?
A: When the body is under significant physical and emotional stress it is possible that the immune system will produce anti-bodies that attack hair follicles, and this results in bald patches or diffuse loss. Stress-induced loss will respond very well to Revita and you should keep using Revita as your regular daily shampoo to keep your scalp healthy.
The Power Plant of the Amazon
March 02, 2007 11:34 AM
It may surprise most Americans to know that rainforest plants are the original source for one-fourth of the chemotherapy medications used today. Plants offer a plethora of beneficial compounds, and rainforests contain a superabundance of beneficial plants.
In fact, plant medicines are the most widely used medicines of all types in the world. Over eighty-five percent of the world’s population uses plant and herbal medicines as their primary medicines. That’s 5.1 billion (5,100,000,000) people worldwide! While Americans overwhelmingly use synthetically manufactured pharmaceuticals to cure their ills, the vast majority of Earth’s inhabitants use healing plant medicines instead.
One of the most powerful healing rainforest plant medicines is cat’s claw, or Uncaria tomentosa. This high climbing woody vine grows at the base of tall trees in the Peruvian rainforest. The plant’s claw-shaped thorns latch onto the trees and spiral further upward, nourished by the lush rainforest environment. For over 2,000 years, the Ashaninka, a tribal people of the Peruvian rainforest, have used the root of U. tomentosa to treat illnesses in the tribe, including asthma, bladder infections, infected wounds, arthritis, bone pain, bowel inflammation, and cancer.
Q. I’ve heard about cat’s claw, but what does it do and how do I know which one is right for me?
Cat’s claw might be one of the most confusing (and most effective!) nutritional supplements available in health food stores today. One reason that it’s so confusing is there are so many kinds of cat’s claw supplements-there are cat’s claw leaves, cat’s claw bark, and even cat’s claw twigs. While each of these supplements claim to help the immune system, it is the root of Uncaria tomentosa that is proven to impart the true cat’s claw health benefits.
Scientists, who have extensively studied every part of the plant, discovered that extracts made from selected cat’s claw roots possess the healing power to treat and prevent diseases like cancer, rheumatoid arthritis, ulcers and degenerative diseases. In addition, it demonstrates anti-inflammatory, anti-viral and anti-microbial benefits.
Adding to the confusion is the fact that not all Uncaria tomentosa roots actually contain healing properties.
Healers in the Ashaninka tribe attribute the healing properties in cat’s claw to the “good spirits” that live in the plant’s roots. The Ashaninka healers, or sancoshi, are able to actually “see” the good spirits hidden inside the root of the plant before they harvest them.
Some cat’s claw plant roots have the good spirits. Some don’t. If the good spirits are mixed with any cat’s claw root without good spirits, the healing power is lost. While there are no apparent differences in the plants or the roots to the untrained eye, only certain cat’s claw roots possess the power to heal. And, for a very long time, only the Ashaninka tribal healer seemed to be able to identify them. They call the good spirit cat’s claw Saventaro, or “powerful plant”.
However, scientists who were given cat’s claw roots by the Ashaninka to study in the laboratory discovered that they could “see” the good spirits, too! Using high performance liquid chromatography, or HPLC, a laboratory process that identifies various chemical compounds, the good spirits of cat’s claw roots were revealed to be important medicinal compounds called pentacyclic oxindole Alkaloids (POAs). Research has learned that POAs provide powerful benefits for the human immune response.
Q. Why are good spirits, or POA’s, good for the immune system?
Cat’s claw POAs work to keep us healthy by directly interacting with white blood cells, the backbone of our immune system. Our white blood cells are the disease fighting cells of the human body. These highly specialized cells fight diseases we catch, such as colds and flu, as well as diseases that start within our own cells, such as cancer and autoimmune diseases. There are many kinds of white blood cells; each has a specific job to do in fighting diseases.
Certain POAs help white blood cells called macrophages work faster. The macrophages’ job is to engulf and digest foreign material. This means that macrophages can ingest m ore bacteria and disease causing microbes when they are exposed to POAs. The scientists also discovered that POA cat’s claw extract increases the production of a chemical protein called interleukin that is secreted by macrophages. This macrophage-secreted interleukin (IL-1) has important immune enhancing properties. IL-1 alerts resting white blood cells and spurs them into action. It also helps make other biochemicals that are essential to an activated immune system.
POAs also help B cells. B cells are white blood cells that make antibodies that kill germs. Each B cell is programmed to make one specific antibody that is effective against one specific germ (such as a bacteria, virus, or fungus). When scientists looked at the number of B cells after they were exposed to POA cat’s claw root extract, they found that the B cells had increased significantly, resulting in an increased supply of antibodies. And perhaps most importantly as they relate to cancer, the POAs in cat’s claw root extract help increase the number of T cells, the true soldiers of the immune system. There are many different kinds of these white blood cells, including Helper T cells, Suppressor T cells, and Killer T cells. Increased Helper, Suppressor, and Killer T-cells can more effectively destroy cancer cells. Increasing the number of circulating T-cells is very important in a disease like AIDS as well.
Q. Can cat’s claw and other plants in the rainforest really cure diseases? Isn’t that just folklore?
It’s folk use and modern science combined-plants have long been known for their ability to kill cancer cells. In fact, the National Cancer Institute (NCI) has identified over 3000 plant extracts that can kill cancer cells. More than 70 percent of these plants are found only in the rainforest.
Q. What is it about the rainforest that gives plants like cat’s claw these cancer killing compounds?
Most of the time when we talk about rainforests, we’re talking about the tropical rainforests. While other forests, like the old-growth temperate forests of the Pacific Northwest, also have high rainfalls and tall trees, the tropical rainforests located near the equator are where most plant medicines come from.
The Amazon rainforest in South America is the world’s largest, covering an area about two-thirds the size of the continental United States. Depending on the elevation and distance to the equator the Amazon rainforest receives between 160 and 400 inches of rain per year. The rain is spread pretty evenly from January to December-it’s always the rainy season-and the temperatures remain between 75-80 degrees Fahrenheit all year.
This fertile environment continually recycles itself. When leaves fall from the trees, flowers wilt, and animals die in the rainforest-all of the nutrients are recycled back into the roots of the trees and plants. Because the rainforest reuses almost everything that falls to the ground, the plant growth is amazingly rich in Alkaloids and other medicinal compounds. Researchers think these compounds and Alkaloids, like POAs, protect the plants from illness and insect attacks. These are the very same compounds that protect us from disease.
Q. When the Ashaninka harvest the cat’s claw roots, does it impact the rest of the plant?
No. The Ashaninka work intelligently to keep rainforest cat’s claw plants perpetually healthy. The Ashaninka employ responsible and innovative harvesting techniques to keep the plants alive and tribal members healthy. Individual cat’s claw plants are never completely harvested. Only one third of the lateral roots are collected at any one time to allow re-growth by the remaining root. Once a plant’s lateral roots have been partially harvested, that plant is left to regenerate, and no more root is harvested from it for 10 years.
Q. Why are the Ashaninka willing to share their cat’s claw?
They are generous people. The Ashaninka see no benefit in hoarding cat’s claw for themselves alone. They also want to make sure that the plant’s healing properties continue on. As their homelands continue to be destroyed by deforestation, rainforest peoples are also disappearing. There were an estimated ten million tribal and indigenous peoples living in the Amazonian Rainforest in 1510. Today there are less than 200,000.
Since the 1900’s more than 90 indigenous tribes have died out and disappeared. Each time a rainforest medicine man or woman dies without passing their arts on to the next generation, the tribe and the world loses thousands of years of irreplaceable knowledge about medicinal plants. With them, centuries of accumulated knowledge of the medicinal value of rainforest species have been lost.
A good example of the impact of this loss can be seen in cat’s claw. When European explorers began venturing into the Amazon River basin, t hey were skeptical of the stories the Ashaninka people told them of U. tomentosa’s amazing healing powers. But when the explorers became sick with colds, flu, or other illnesses, they harvested cat’s claw root for themselves and gave the plant a try. Sometimes the explorers got better when they used the cat’s claw root, sometimes they stayed the same.
Q. Why didn’t the cat’s claw root help all the explorers?
Because some cat’s claw plant roots have good spirits-POAs-and some cat’s claw plant roots have tetracyclic oxindole Alkaloids, or TOAs. While the POAs have very powerful effects in the immune system, the TOAs have different effects in the body, none of which help the immune system cells at all. All U. tomentosa plants look virtually identical, so it’s hard to tell if they have the healing POAs or non-helpful TOAs.
What makes cat’s claw identification even more challenging is the fact that plants with POAs one year will have TOAs the next. Cat’s claw plants seem to change their Alkaloid chemotypes at will, an incredibly powerful accomplishment for a plant to possess. Harvesting of cat’s claw roots that contain POAs is very tricky. Unless the person gathering the root extract is an Ashaninka sancoshi. These medicine men know which cat’s claw to use; they can actually “see” the good spirits hidden inside the root. When scientists studying cat’s claw discovered they could “see” presence of TOAs using HPLC technology, they were able to harvest cat’s claw root extracts with POAs that consistently helps people get and stay healthy.
Q. Do some cat’s claw root extract supplements contain TOAs?
Yes they do. And buying those products will only benefit the cat’s claw distributor; they won’t help you stay healthy. When cat’s claw root is harvested from the rainforest, responsible supplement maker examine the root with HPLC to make sure that only POA roots are collected. But, this identification of the chemotypes takes significant time and costs money. For these reasons, many cat’s claw distributors don’t include this important process in their harvesting. The POAs and TOAs are simply just mixed together and sold as a cat’s claw product with no mention of any Alkaloid content on the label.
Q. Why should I avoid TOAs?
While the POAs in cat’s claw root extracts have numerous benefits to the immune system, the TOAs have different effects in the body, none helping the immune system cells. Most importantly, however, when POAs and TOAs are mixed together, the TOAs actually work against the POAs. TOAs reduce the capacity of POAs to beneficially modulate the immune system.
Q. How can I be sure the cat’s claw I buy is POA cat’s claw?
Read the label of the cat’s claw root extract product you are considering buying. If it does not clearly state that it is the high POA cat’s claw, then chances are that it’s not.
Q. What do the Ashaninka receive in return for the cat’s claw harvesting?
The Ashaninka and reputable distributors of cat’s claw root extract have established a mutual and ethical relationship. Both groups benefit from the sale of the plant material. Maintaining this relationship is important for both the tribe and the distributors.
The distributors are paying a fair price for the raw material directly to the tribe. No intermediary is involved. This payment covers the raw material itself, a license-fee for the k knowledge of the plant, and a guarantee (from both sides) of a lasting relationship. Payment is also made for the protection of the rainforest. No deforestation is allowed. The area where the cat’s claw materials are processed is also leased and payment is made for this, as well.
This arrangement allows the Ashaninka to make independent decisions in how to spend this income from sale of their cat’s claw plants. They have been able to make improvements in the tribe’s water supply and in their living areas. They are also able to obtain outside medical aid as needed and provide for education of their children.
The partnership with cat’s claw distributors has created a sustainable resource for the Ashaninka. The tribe has been able to not only preserve their rainforest, but also compete financially with unsustainable income sources offered by timber and agricultural firms.
Q. Why is it important to preserve the rainforest?
The most amazing fact about these impressive medicinal plants is the vast number that5 has yet to be discovered. In fact, the rainforest’s abundance is one reason it is home to so many healing plants. Within a four square mile patch of rainforest, you could see 1500 species of flowering plants, 750 species of trees, 125 mammal species, 400 species of birds, 100 reptile species, 60 amphibian species, and 150 different species of butterflies.
Unfortunately, not everyone looks to the rainforest for the same reasons. Many consider its real value in board feet and cultivated acreage. The forces pushing industrial development move quickly; experts estimate that we’re losing over 130 plant, animal, and insect species every day/ That amount to almost 50,000 species a year.
A combination of logging, petroleum interests, cattle grazing operations, and, of course, our own consumer appetites are putting pressure on rainforest resources. The consequences are sobering:
By leaving the rainforest intact, however, and harvesting its many nuts, fruits, oil-producing, and medicinal plants, the rainforest has more economic value than if it was cut down for timber or to make grazing land for cattle. If managed properly, the rainforest can provide the world’s need for sustainably harvested natural resources on a perpetual basis. That’s what the Ashaninka are doing with their cat’s claw harvesting.
The discovery of medicinal plants is dependent upon healthy rainforests. When an acre of tropical rainforest is lost due to deforestation, the impact on the number of plant and animal species lost and their possible uses is staggering.
We can all help the development of sustainable rainforest industries. By purchasing renewable and sustainable rainforest products, like POA type cat’s claw root extract, we are keeping rainforests alive and well. By benefiting from the innate wisdom of the Ashaninka people we are keeping ourselves just as alive and well. By honoring the science and the sacred of the world’s rainforests, like my friend the oncology nurse, the massive wealth and diversity will be there for generations to come.
Benefits - Supports joint function and tissue health*
December 11, 2006 03:46 PM
To understand glucosamine's role, it is important to understand joint structure and function. Cartilage in the joints acts as a shock absorber to cushion the blows of daily wear and tear. Joint cartilage is made of a unique connective tissue that consists of collagen and proteoglycans. Collagen is a strong, fibrous, insoluble protein. Proteoglycans are large, carbohydrate-rich protein chains made up of 95 percent polysaccharides and 5 percent protein called glycosaminoglycans (GAGs). GAGs are composed of repeating two-sugar units (disaccharides) that contain glucosamine sulfate and other amino sugars. Surrounding the joint cartilage is synovial fluid, which contains many substances including its chief component, hyaluronic acid. Hyaluronic acid forms the backbone of other proteoglycans and is responsible for the thickness of synovial fluid as well as its lubricating and shock-absorbing properties. Synovial fluid also provides nutrients for the joint cartilage.
Glucosamine sulfate is a normal constituent of glycosaminoglycans in cartilage and synovial fluid. In essence, glucosamine sulfate provides important building blocks for cartilage production. Laboratory studies suggest that glucosamine may also function to stimulate production of cartilage-building proteins. It is also thought that the sulfate portion of the molecule contributes to the efficacy of glucosamine sulfate in the synovial fluid by providing the elemental sulfur needed for strengthening cartilage and aiding glycosaminoglycan synthesis. 1,2,3
Glucosamine sulfate has been the subject of research for over twenty years. Clinical trials as well as experimental studies have repeatedly supported the efficacy of oral glucosamine sulfate in supporting joint function. In one large open trial, over 1200 people took oral glucosamine sulfate for periods ranging from 36 to 64 days. In this multi-center trial, ninety-five percent of the subjects experienced greater joint comfort and increased mobility. The physicians reported "good" results in 59%, and "sufficient" results in 36%. Furthermore, the improvements in joint health lasted for up to three months after the glucosamine sulfate was discontinued. 3
Promotes optimal joint comfort, function and flexibility*
Boswellia serrata (Indian frankincense) has been used for centuries in the Indian Ayurvedic system of medicine to maintain healthy joints. Even today, this is one of the primary uses for this plant in Ayurvedic medicine. Boswellic acids have been shown to support healthy joint tissue, maintain circulation to joints, enhance joint mobility, and promote joint comfort in animal models without known side effects. 4
Boswellin® is an extract rich in boswellic acids. Boswellic acids are potent modulators of enzymes involved in leukotriene synthesis in vitro, promoting a healthy balanced production of these components of the immune system.5 Healthy leukotriene balance can lead to enhanced joint function. A human clinical study was conducted to assess the effects of supplementation with a formula containing Boswellia, Curcumin and other nutrients on joint function. In this double-blind placebo-controlled crossover trial, participants were randomly assigned to receive the herbal formulation or a placebo for 3 months. Following this 3-month period, the treatments were reversed for an additional 3 months. The results showed that while each group was receiving the herbal formulation, they had superior joint function and a greater sense of joint comfort when compared to the placebo groups.6 Other trials lend further support to Boswellia’s ability to promote healthy joint function.4,6,7
Curcumin is a potent antioxidant that has known free radical scavenging activity. This activity of Curcumin is thought to play a major part in its role as a joint protective nutrient. In fact, the numerous beneficial effects attributed of whole turmeric are thought to stem in large measure from the antioxidant properties of curcuminoids. Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is not toxic to cells, even at high concentrations. Pure Curcumin was shown to be less protective than a mixture of curcuminoids, indicating a possible synergism among the curcuminoids.8
Curcumin demonstrates several other in vitro effects linked to free radical scavenging. Curcumin scavenges nitric oxide, a compound associated with the body’s inflammatory response.9 Curcumin also demonstrates in vitro inhibition of certain enzymes involved in promoting inflammatory reactions in the body. Together these results strongly suggest that Curcumin is a potent bioprotectant with a potentially wide range of therapeutic applications.9,10,11
Preliminary human trials have assessed the therapeutic potential of Curcumin, with results that verify the traditional use of turmeric as an herb to enhance joint health. In a short-term double-blind, cross-over, comparative study, eighteen people were randomized to receive Curcumin (1200 mg daily) or an alternative therapy for two-week periods. The participants in the Curcumin groups were shown to produce measurable enhancements in joint flexibility and walking time.12 Research suggests that Curcumin and Boswellia work extremely well in combination to benefit joint health and mobility, as trials combining both nutrients have yielded highly positive results.
Bioperine-Nature’s Absorption Enhancer Boosts Nutrient Absorption*
Traditional Ayurvedic herbal formulas often include black pepper or long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the Alkaloid, piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that piperine significantly enhances bioavailability when consumed with other substances.13 Several double-blind clinical studies have confirmed that Bioperine® increases absorption of nutrients.14
Curcumin is known to be poorly absorbed in the intestinal tract when used on its own, thereby limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in the bloodstream. However, a study has shown that concomitant administration of 20 mg of piperine with 2 grams of Curcumin was able to enhance Curcumin bioavailability by an astounding 2000%. 15 These results speak to the wisdom of including a small amount of Bioperine® in the formulation to ensure nutrient bioavailability.
Sustained Release – For lasting joint comfort and convenient dosing
To ensure that the body can utilize all of the joint health-enhancing nutrients effectively, Best Joint Support featuring ArthriBlend-SR™ has been designed to have a sustained release delivery system. The nutrients are released over a longer period of time, maximizing absorption and providing the comfort-enhancing properties in a sustained manner. This unique delivery system allows the product to be taken just twice daily while maintaining its efficacy throughout the day.
Suggested Adult Use: Take two tablets every 12 hours. Take 4 tablets daily.
2. Tapadinhas M.J., Rivera, I.C. Bignamini, A.A. Oral glucosamine sulphate in the management of arthrosis: report on a multi-centre open investigation in Portugal. Pharmatherpeutica 1982; 3(3):157-68.
3. Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Current Medical Research and Opinion 1982; 8(3):145-149.
4. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.
5. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M.I., Subramanian, L.R., and Ammon, H.P.T. (1992) Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146.
6. Boswellia serrata. Alternative Medicine Review Monographs – Volume One. 2002.
7. Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991 May-Jun;33(1-2):91-5.
8. Majeed, M., Badmaev, V., Shivakumar, U., Rajendran, R. Curcuminoids: Antioxidant Phytonutrients. 1995. Piscataway, NJ: NutriScience Publishers.
9. Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae). The Protocol Journal of Botanical Medicine, Autumn 1995:43-46.
10. Rao, S., Rao, M.N.A. Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol. 1997;49:105-7.
11. Ramsewak, R.S., DeWitt, D.L., Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory activities of Curcumins I-III from Curcuma longa. Phytomedicine 2000;7(4):303-308.
12. Deodhar, S.D., Sethi, R. Srimal. R.C. Preliminary study on antirheumatic activity of curcumin (diferoyl methane). Indian J Med Res 1980;71:632-34.
13. Atal, C., Zutshi, U., Rao, P. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. Journal of Ethnopharmacology 1981;4:229-232.
14. Bioperine®–Nature's Bioavailability Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa Corporation, Piscataway, N.J.
15. Shoba, G., et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica 1998;64(4):353-6.
Q. What is cat’s claw?
November 22, 2006 01:37 PM
A. Cat’s claw might be one of the most confusing (and most effective!) nutritional supplements available in health food stores today-with some fairly good reasons.
First its mere name can be bewildering. Currently, there are at least 16 plants in the world that are called cat’s claw. Sometimes these plants are referred to as “Una de Gato”, Spanish for cat’s claw. While Uncaria tomentosa is the Latin name of the plant most frequently sold as cat’s claw supplements, these products vary vastly. Some cat’s claw nutritional supplements contain cat’s claw bark, some contain cat’s claw stems, and others contain compounds from the leaves of cat’s claw. All of these claim to help the immune system. However, it is the root of Uncaria tomentosa that actually contains the true cat’s claw health benefits. Scientists, who have extensively studied every part of the plant, discovered that only extracts made from cat’s claw root possess the healing power to treat and prevent disease. While it would seem that this vital understanding might help clear up some cat’s claw confusion, not all Uncaria tomentosa roots actually contain healing properties.
To determine which cat’s claw roots do have healing properties, we have to go to the rainforests of Peru. This is where Uncaria tomentosa thrives. It’s a woody vine that’s found at the base of tall trees in the rainforests. As the plant grows, it winds up and around the tree, attaching itself to the trunk with curved cat-like claws found at the junctions of its leaves. The Ashaninka Indians, who make these rainforests their home, have used the roots of the cat’s claw plant for thousands of years to cure illness and maintain health in the tribe.
Healers in the Ashaninka tribe attribute the healing properties in cat’s claw to the “good spirits” that live in the plant’s roots. In order to obtain these healing properties, the correct cat’s claw root must first be harvested. The Ashaninka healers know which cat’s claw to use; they can actually “see” the good spirits hidden inside the root of the plant before they collect them. Some cat’s claw plant roots have the good spirit. Some cat’s claw plant roots don’t. If the cat’s claw root with good spirits is mixed with any cat’s claw root without good spirits, the healing power is lost. While there are no visible differences in the plants or the roots, only certain cat’s claw roots possess the power to heal. And, only the Ashaninka tribal healers seem to be able to see them.
Amazingly, however, scientists who were given cat’s claw roots by the Ashaninka to study in the laboratory discovered that they were able to “see” the good spirits, too! Using high performance liquid chromatography, or HPLC, a laboratory process that identifies various chemical compounds, the good spirits of cat’s claw roots were revealed to actually be important medicinal compounds, called pentacyclic oxindole Alkaloids (or POAs).
At the same time, the scientists studying cat’s claw found they could “see” the non-healing properties as well. Again, using HPLC, they also discovered the presence of tetracyclic oxindole Alkaloids (or TOAs) in certain cat’s claw roots. While the POAs have very powerful effects in the immune system, the TOAs have different effects in the body, none of which help the immune system cells at all.
And, if the TOAs and POAs are mixed together (as so often happens in the vast majority of cat’s claw products), the resulting product is useless to healing and health. The TOAs cancel out the action of the POAs, making the cat’s claw root extract ineffective. Even as little as 1% TOA content can cause POAs to lose their ability to beneficially modulate the immune system.
This means that cat’s claw supplements that contain only POAs (in other words, cat’s claw that is 100% TOA-free) from the root of the plant will provide powerful effects in the immune system.
Ban against ephedra supplements at any does upheld.
August 22, 2006 11:48 AM
A three-judge panel of the 10th U.S. Circuit Court of Appeals in Denver late last week overturned a 2005 ruling by a Utah district court that had allowed the sale of low-dosage ephedra dietary supplements containing 10 milligrams or less of ephedrine Alkaloids.
The appellate decision, which is effective immediately, supports FDA’s original determination that no dosage of ephedra is safe for consumption and means that it is unlawful to manufacture and sell any supplements containing ephedra, even products containing low doses of the herb.
The original ban was challenged in a May 2004 lawsuit by Nutraceutical Corp, and its subsidiary Solaray Inc., which said dried whole-herb ephedra sinica - the type of supplement in their products – had been safely used for thousands of years.
The U.S. district judge in Utah blocked any enforcement action against Nutraceutical for selling supplements containing 10 milligrams or less of ephedra per daily dose. The Utah District Judge said FDA’s process in banning ephedra improperly shifted the burden of proving product safety from the government to supplement manufacturers.
While noting that the Dietary Supplement Health and Education Act of 1994 (DSHEA) categorized dietary supplements as foods and are not, therefore, subject to premarket approval by FDA, the appellate panel found that the Utah district court had interpreted this basic provision to narrowly.
The panel said that the Food, Drug and Cosmetic Act (FDCA), of which DSHEA is a part, should not be interpreted “too restrictively” but should instead be read in a manner “consistent with the statute’s overwhelming purpose to protect public health.”
Nutraceutical’s attorney has indicated that the company would appeal the ruling to the full appeals court.
Butterbur Extract Fact Sheet
December 08, 2005 04:22 PM
Butterbur Extract Fact SheetNeil E. Levin, CCN, DANLA 8/1/05
LIKELY USERS: People wanting to support healthy blood flow to the brain and healthy neurological function 1-6,10 Those maintaining normal seasonal immune responses 7-10
KEY INGREDIENTS: 75 mg of Guaranteed Potency Butterbur Root (Petasites hybridus) Extract, min. 15 Sesquiterpenes as Petasines; 200 mg of Feverfew Leaf (Tanacetum parthenium) min. 0.4% Parthenolides
MAIN PRODUCT FEATURES: Butterbur (Petasites hybridus) is a native shrub of Europe, North America, and Asia that has been used by herbalists for centuries. Modern scientific studies have demonstrated that Butterbur supports healthy blood flow to the brain and healthy neurological function.1-6, 10 In addition, Butterbur may help to maintain balanced seasonal immune responses.7-10 In a synergistic base of guaranteed potency Feverfew leaf.11-26
ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: NOW Butterbur is free of harmful levels of Pyrrolizidine Alkaloids (PAs), the undesirable compounds naturally found in Butterbur, so it is safe to use regularly.
SERVING SIZE & HOW TO TAKE IT: Take one VCap one to three times per day, or as directed by your physician.
COMPLEMENTARY PRODUCTS: Magnesium, Ulcetrol, B-2, B-12, Fish Oil (EPA, DHA), SAM-e, Ginger, Ginkgo Biloba
SPECIFIC: Do not discontinue use abruptly; taper off use if discontinuing. Discontinue use at least 14 days before surgery or oral surgery. Use with caution if you have ragweed allergies or blood disorders and let your physician know that you plan to use it before you take it. May be contraindicated for pregnant women.
GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
1. Diener HC, Rahlfs VW, Danesch U (2004) The First Placebo-Controlled Trial of a Special Butterbur Root Exract for the Preventio of Migraine: Reanalysis of Efficacy Criteria. Eur Neurol 51:89-97.