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Betaine aka TMGs Many Benefits as a Methyl Donor Darrell Miller 10/21/22
Pomegranate can prevent the growth and spread of four common typesof cancer cells Darrell Miller 4/26/19
Stop feeding cancer cells! This is the diet mistake you probablymake that can cause cancer VitaNet, LLC Staff 9/5/18
The health benefits of eating pecans Darrell Miller 8/3/18
St. John’s wort: A scientific review of its remarkable antibacterial and antioxidant properties Darrell Miller 2/7/18
fight cancer with baking soda Darrell Miller 5/16/17
Gut bacteria may hold key to treating autoimmune disease Darrell Miller 12/29/16
Nourish your bones with vitamins - The Detroit News Darrell Miller 12/13/16
Superoxide Dismutase (SOD) and its Protection of the Liver Darrell Miller 9/27/15
STEVIA – BETTER THAN SUGAR Darrell Miller 7/29/15
The Dangers of Vegetable Oil Darrell Miller 7/21/15
Why Is Acai, Goji, Pomegranate, Noni And Mangosteen Called Super Fruits? Darrell Miller 1/15/13
Grape Seed or Pine Bark Extract, Which Is Best? Darrell Miller 10/27/11
Boost Brain Chemistry, Lower Bad Cholesterol, And More Darrell Miller 5/12/11
Can a Lactase Enzyme Help with Milk Digestion Darrell Miller 4/27/11
Turmeric, Curcumin, And Good Health Darrell Miller 11/11/10
Pine Bark Extract Darrell Miller 10/7/09
Turmeric Extract (Curcumin) Darrell Miller 2/10/09
Red Pepper, Cayenne, Capsicum Darrell Miller 12/18/08
Polyphenols is an Antioxidant Darrell Miller 10/13/08
Antioxidants Darrell Miller 8/14/08
Protect Your Skin Darrell Miller 8/11/08
Antioxidants For The Body Darrell Miller 6/10/08
Copper Darrell Miller 5/15/08
Curcumin, Curcuminoids, and Curamin Darrell Miller 4/30/08
Gently Narrow Your "Estrogen Window" With Lignan's Darrell Miller 1/25/08
Elderberry Can Boost The Immune System In The Winter Darrell Miller 12/3/07
EpiCore Benefits Darrell Miller 4/9/07
At Last some good news concerning breast health! Darrell Miller 2/23/06
GliSODin Anti-Aging and Antioxidant Protection Darrell Miller 12/19/05
The Free Radical Theory Darrell Miller 12/14/05
New Test for Early Cancer Detection Darrell Miller 10/18/05
Curcumin - Turmeric Extract Darrell Miller 8/19/05
SAFETY Darrell Miller 7/15/05
SUMMARY OF SPECIFIC ACTIONS ASSOCIATED WITH PYCNOGENOL Darrell Miller 7/13/05
PYCNOGENOL - ITS REMARKABLE BENEFITS Darrell Miller 7/13/05
HERBAL FIRST AID KIT Darrell Miller 7/11/05
HAWAIIAN NONI (Morinda citrifolia) Darrell Miller 7/11/05
GLISODIN POWER - Superoxide Dismutase (SOD) Darrell Miller 6/29/05
Colo-rectal Cancer and Fat Darrell Miller 6/25/05
CANCER TREATMENT AND PREVENTION WITH GARLIC Darrell Miller 6/25/05
CLINICAL APPLICATIONS OF CAPSICUM Darrell Miller 6/23/05
Introduction Darrell Miller 6/22/05
Anti-Aging Nutrients Darrell Miller 6/18/05
Botanical Arsenal - Plants can help our bodies fight off cancer's deadly ... Darrell Miller 6/13/05
Cancer at the Millenium - the war on cancer entering its third decade... Darrell Miller 6/13/05
Go Green - green foods may be the SWAT team that sets you free... Darrell Miller 6/12/05
Nutrients for Longevity Darrell Miller 6/10/05
Breast Cancer Darrell Miller 6/10/05




Betaine aka TMGs Many Benefits as a Methyl Donor
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Date: October 21, 2022 12:29 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Betaine aka TMGs Many Benefits as a Methyl Donor

Methylation is a process in the body that helps to produce DNA, keep hormones in balance, and support detoxification. You need methyl groups for this process to happen, and TMG (trimethylglycine) donates methyl groups to help with methylation. TMG also supports cardiovascular health and cognitive function while reducing inflammation.

Not sure if TMG is right for you? Keep reading to learn more about this methyl donor’s benefits.

Benefit #1: TMG Promotes Healthy Methylation

As we just touched on, one of the main benefits of TMG is that it promotes healthy methylation. As we know, methylation is important for DNA production, hormone balance, and detoxification support.

TMG provides the extra push of methyl groups needed to keep these processes running smoothly which is why it’s often taken as a supplement. If you have difficulty methylating or you have a genetic mutation that affects methylation, TMG may be a good supplement for you to consider. Check with your doctor first, of course!

Benefit #2: TMG Supports Cardiovascular Health

TMG also known as betaine, can improve cardiovascular health by reducing homocysteine levels. Homocysteine is an amino acid that at high levels has been linked to heart disease. While more research needs to be done in this area, initial studies are promising.

In one study of nearly 500 participants, researchers found that those who took TMG had lower levels of homocysteine than those who didn’t supplement with the nutrient [1]. While this doesn’t prove causation, it’s an interesting correlation worth noting—especially given that other studies have found similar results [2].

benefit #3: May Reduce Inflammation

Chronic inflammation has been linked to many diseases such as heart disease, arthritis, and even cancer. Some studies suggest that TMG may help reduce inflammation levels in the body [3]. In one animal study, rats given TMG had reduced lung inflammation compared to rats who weren’t given the supplement [4]. More research needs to be done in this area but initial studies are promising.

In Summary:

TMG is a nutrient known as a methyl donor which means it provides methyl groups needed for processes like DNA production and hormone balance. It also supports cardiovascular health and cognitive function while reducing inflammation. If you have difficulty methylating or you have a genetic mutation that affects methylation, TMG may be a good supplement for you to consider. Check with your doctor first!

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Pomegranate can prevent the growth and spread of four common typesof cancer cells
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Date: April 26, 2019 02:26 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Pomegranate can prevent the growth and spread of four common typesof cancer cells





There is a protective enzyme within pomegranate that is known scientifically as paraoxonase-1 (PON-1), and it has the ability to block oxidative stress that promote DNA mutations. These DNA mutations are often what lead to a cancer diagnosis. More research determined that not only does pomegranate help block gene mutations, but it can also stop the replication cycle of cancer cells in which they grow at alarming rates. Not only can it help disrupt this cycle, but it can also kill some cells altogether.

Key Takeaways:

  • The US centers of disease control states that the incidence of cancer is expected to go up by about 24 percent in men and 21 percent in women.
  • There is now the need for more novel and more proactive methods of treating cancer, based on the grim statistics, and pomegranate is one of those promises.
  • Pomegranate benefits does not lie only in the fact that it contains antioxidant polyphenols for combating oxidative stress but also has multiple actions against cancer cells.

"In one study, a cup of day of pomegranate juice lowered inflammatory markers – such as C-reactive protein and interleukin-6 – in diabetic patients."

Read more: https://www.naturalhealth365.com/pomegranate-cancer-cells-2628.html

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6194)


Stop feeding cancer cells! This is the diet mistake you probablymake that can cause cancer
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Date: September 05, 2018 09:52 AM
Author: VitaNet, LLC Staff (support@vitanetonline.com)
Subject: Stop feeding cancer cells! This is the diet mistake you probablymake that can cause cancer





Stop feeding cancer cells! This is the diet mistake you probably make that can cause cancer

Although we tend to associate fashion with things like neckties, the truth is scientific ideas go in and out of fashion as well. Various pet theories their have their moment in the sun and then slip quietly below the radar as another more intriguing idea grabs everyone's attention. In the 2000s it was all about genetics and DNA. The Genome project, which would take on the lofty goal of mapping human DNA, thereby aiding scientists in their search to discover the mutations that lead to cancer, or so it was assumed. In actuality the search for causative mutations petered off into almost nothing. Some tumors had no mutations. Nor was there any sort of common DNA factor.

However, it hasn't proven to be a trek back to square one precisely. A Nobel prize winner back in the thirties had a theory that though not conclusive was compelling. This scientist, Warburg, surmised that when the body's mitochondrial cells produced energy as they were supposed to, which is aerobically, the body remains healthy. When energy production became anaerobic, a process that produces lactic acid in the body, then cancer cells would proliferate. To starve these renegade cells, the body would have to re-shift back away from the lactic-acid producing energy style, back to the more positive aerobic method. Some more recent scientists have started to build on Warburg's ideas, even discovering that sugar is a specific for cancer cells, without which they starve. So a best case scenario proposed diet for those with cancer would include high fats, less than fifty percent carbs, and a small amount of protein. Because of the relationship with sugar some diabetes drugs may have secondary use as a way to fight cancer as well.

Key Takeaways:

  • The Human Genome project, which was to map human DNA and discover all the causative mutations leading to human cancers began around the 2000s.
  • Unfortunately, scientists had not allowed for how random mutations are and no specific genetic cause of cancer could be tracked down.
  • Warburg, surmised that when human cells shifted from an aerobic style of energy production to an anaerobic style, then cancer cells proliferated.

"In 1931, Dr. Otto Warburg won the Nobel Prize Physiology or Medicine for his discovery that cancer cells have a fundamentally different energy metabolism compared to healthy cells."

Read more: https://www.healthnutnews.com/stop-feeding-cancer-cells-this-is-the-diet-mistake-you-probably-make-that-can-cause-cancer/

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5747)


The health benefits of eating pecans
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Date: August 03, 2018 09:53 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: The health benefits of eating pecans





The health benefits of eating pecans

Pecans originate from the Midwestern part of the US, and their health benefits are shown to be quite substantial. Pecans are high in vitamin E, which causes them to have large amounts of antioxidants properties. They can also help clean and regulate oxidation processes in order to help contribute to the prevention of various cancers. Studies have indicated that consumption of pecans may also have the ability to help those with liver damage, but it has not been proven in human subjects as of right now.

Key Takeaways:

  • Pecans are rich in nutrients that can help people avoid cardiovascular disease.
  • The phenolic acids in pecans are key in preventing cell mutations, which in turn can prevent cancer from developing.
  • Unfortunately, many pecan recipes require a lot of sugar and corn syrup, but there are recipes available that use natural ingredients.

"Referred to as Carya illinoinensis in scientific literature, pecans are a member of the Juglandaceae family, which makes it a relative of the hickory and the walnut. Pecans are also considered native to North America; their existence has predated even the earliest human settlements."

Read more: https://www.naturalnews.com/2018-06-11-the-health-benefits-of-eating-pecans.html

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St. John’s wort: A scientific review of its remarkable antibacterial and antioxidant properties
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Date: February 07, 2018 03:59 PM
Author: Darrell Miller (support@vitanetonline.com)
Subject: St. John’s wort: A scientific review of its remarkable antibacterial and antioxidant properties





St. John’s wort A scientific of this remarkable antibacterial and antioxidant properties study was from African but how some bacteria affect some crops that man nee for consumption and this is the bacteria strains which cause mastitis[ this happens when breast tissue is infected.], and also create problems for the mammary glands in terms of inflammation. Overall, researchers found out the H. perforatum extract contained significant antibacterial properties, which could have potential pharmacological uses — particularly in plant-based medicine.

Key Takeaways:

  • St. John's wort is a timeless herbal remedy that must be tried. It is best known for its antioxidant property that can be used.
  • The plant does have an ability to counter cell mutation in the body. That will open the door to further research to be undertaken.
  • A simple scientific review has been issued for St. John's wort. The remedy has an incredible array of antibacterial and antioxidant properties.

"While it exhibited antioxidant property, the research team posited that the plant’s ability to counter cell mutation opens the door to further research."

Read more: https://www.naturalnews.com/2018-02-05-st-johns-wort-a-scientific-review-of-the-antibacterial-and-antioxidant-properties.html

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fight cancer with baking soda
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Date: May 16, 2017 04:44 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: fight cancer with baking soda





Baking soda can be used for cancer prevention. Baking soda has natural elements that allow the body to regulate pH levels. Regulating pH levels can help prevent the mutations that may cause cancer to form. Baking soda also has many other properties that can be relied on to detoxify the body. Detoxifying the body can also prevent a host of other ailments that are related to the occurrence of cancer. Few natural substances can be used to prevent cancer like baking soda.

https://www.youtube.com/watch?v=ADq64EeExow&rel=0

Key Takeaways:

  • Baking soda helps reduce acid reflux in the body which in turn promotes overall health.
  • Cancer cells thrive in high acid. Baking soda reduces the acid level thus slowing the spread of cancer.
  • Healthy blood VB pH levels is key to over all healthy living. Keeping pH right reduces the chances of getting cancer. Baking soda helps reduce acid restoring this balance.

"Many buffering systems equip the human body with the ability to optimize internal functions for as long a period as possible."

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Gut bacteria may hold key to treating autoimmune disease
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Date: December 29, 2016 07:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Gut bacteria may hold key to treating autoimmune disease





Inflammation and autoimmunity are caused by inappropriate activity of the body's own regulatory T immune cells. A mutation in a gene called Foxp3 causes a fatal disease, IPEX syndrome, where these cells run amok. But new research shows an unexpected link to the gut: Foxp3 mutant mice end up missing a particular type of bacteria from their intestines. By replacing the missing bacterial species in the gut microbiome, many of the T cell-mediated inflammatory symptoms could be improved.

Key Takeaways:

  • T reg cells suppress the immune system and prevent it from attacking the body's own tissues by mistake.Defects in T reg cells therefore lead to various types of autoimmune disease.
  • This inherited autoimmune disorder is characterized by a variety of inflammatory conditions including eczema, type I diabetes, and severe enteropathy.
  • Autoimmune diseases can also be caused by changes in the gut microbiome, the population of bacteria that reside within the gastrointestinal tract.

"The study, published online in The Journal of Experimental Medicine, suggests that replacing the missing gut bacteria."



Reference:

https://www.google.com/url?rct=j&sa=t&url=//news.webindia123.com/news/Articles/India/20161220/3016593.html&ct=ga&cd=CAIyGmZmMDFkMTU2YWMzMmQ5OTU6Y29tOmVuOlVT&usg=AFQjCNFb8uS7IaUdJHpkyGkFpLZ5BESXeA

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3715)


Nourish your bones with vitamins - The Detroit News
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Date: December 13, 2016 06:59 AM
Author: Darrell Miller (support@vitanetonline.com)
Subject: Nourish your bones with vitamins - The Detroit News





Bones are constantly being broken down and rebuilt to make it stronger. To decrease the chance of the "replacement bones" of being weaker, there are a few vitamins that will make your bones stronger. These vitamins include Vitamin D, Calcium, Magnesium, Vitamin K, Vitamin B12, and Folate. These vitamins can be taken in pill form or be found in certain foods.

Key Takeaways:

  • Unlike the static human skeletons that commonly hang in biology classrooms, your bones are continually being broken down and rebuilt.
  • Vitamin D helps you absorb calcium from food and supplements. Without vitamin D, less than 10 percent of the calcium you consume is absorbed.
  • Magnesium is a component of bone, giving it resiliency and protection against fractures; it also is essential for converting vitamin D to its active form in the body.

"Vitamin B12 and folate support bone health by helping to keep levels of homocysteine, a compound that stimulates the breakdown of bone, low. This role is further confirmed by genetic studies that reveal a link between an increased risk of osteoporosis in older adults and a common gene mutation (MTHFR C677T) that can lead to high homocysteine levels."



Reference:

//www.detroitnews.com/story/life/food/2016/12/04/nourish-bones-vitamins/94692746/

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Superoxide Dismutase (SOD) and its Protection of the Liver
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Date: September 27, 2015 08:37 AM
Author: Darrell Miller
Subject: Superoxide Dismutase (SOD) and its Protection of the Liver

SOD consists of enzymes that speed up the break-down or partition/dismutation of the superoxide (O2-) radical into its constituent molecular content Oxygen or hydrogen peroxide. Superoxide is harmful to cells and is produced as a by-product of oxygen metabolism; therefore it needs to be controlled or regulated. The resultant Hydrogen peroxide is also harmful but to a less extent, and it is further broken down by other enzymes like catalase, This sums up the crucial role played by Superoxide Dismutases (SOD) as an important antioxidant in almost all living organism exposed to oxygen.

SOD extracted or laboratory manufactured can be used as a medicine orally or taken as an injection. When taken orally it is believed to remove wrinkles, rebuilding tissue, and prolonging life; even though it is not proven that orally administered SOD is absorbed by the body. When injected it functions as a painkiller, treatment of inflammation caused by sports injuries, osteoarthritis, kidney condition known as interstitial cystitis, gout, cancer, lung problems in infants among others.


A critical role played by SOD IS the protection of the Liver; which is one of the most crucial organ in the body for it is engaged in high-level metabolism in its function of detoxifying chemicals, breakdown of drugs and conversion of certain food into necessary nutrients for the body. These processes entail the high use of oxygen needed by the liver cells in the effort to function optimally and thus the production of the harmful Superoxide as a by-product. SOD as an enzyme helps to break down this harmful by-product that is potentially harmful to the liver cells and consequently prevent tissue damage.

SOD also prevents oxidative tissue damage of the liver as the result of strenuous exercise. Exhausting exercise or running causes a significant surge in the activities of glutathione peroxidase (GPX), and xanthine oxidase (XO), and in addition to increased levels of thiobarbituric acid-reactive substances (TBARS) in liver tissue immediately after the activity. Scientific studies have revealed that effective protection of the liver against such oxidative damages requires increased dosage of the antioxidant SOD.


Reference:

//www.ncbi.nlm.nih.gov/pubmed/8820884

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STEVIA – BETTER THAN SUGAR
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Date: July 29, 2015 05:11 PM
Author: Darrell Miller
Subject: STEVIA – BETTER THAN SUGAR

Stevia is a natural sweetener that originates in South America – Paraguay and Brazil, mostly – with no calories and is remarkably much sweeter than sugar.  The stevia plant Stevia Rebaudiana derives its sweetness from steviol glycocides.  The extract is then processed for sale in the form of Truvia and PureVia around North America.  It is not yet approved as an additive due to possible side effects of male infertility and genetic mutations.

Stevia

Benefits of Stevia over Sugar

  • Efficient. Stevia is very potent as a sweetener and contains multiple times the sweetness of sugar.  This means less of it is required to have a similar effect on intake. The leaf itself can stay up to five years, so it is a worthy investment as a plant. It saves money and allows for multiple use of a very small quantity.
  • Low Calorie Count. Stevia has been a revelation for health freaks around the country. It has no calories, affects neither insulin nor blood sugar levels and does not contribute to dental cavities. It is thus a healthier and cleaner way to indulge your sweet tooth. This is a great tool to combat the rising obese statistics and keep folks in better nick.
  • Suppresses Craving. Stevia does not spike your thirst for a sugar spree as much as aspartame and sucralose products. The common helplessness to sugar products once tasted leading to wanting more can be combated with stevia. As opposed to other sweeteners bringing about dizziness, headaches and rashes, stevia is a serene product that will not enslave you to sugar and enable you to keep it natural.
  • Teeth Saver. Stevia acts as a polyol would in that dental bacteria from sugar consumption cannot ferment it thus preventing tooth decay and plaque. Erythritol, Maltitol and Solbitol are in most gums and toothpastes as sugar alcohols, but have a lot of calories and can affect diabetics due to their high glycemic index. Stevia does the same job but with no calories and poses no threat to diabetics.
  • Safe for Diabetics. The glycemic index is a measure of how much sugar, carbohydrates contain and the energy used to break them down. The higher the glycemic index, the more unsafe, it is for diabetics. Apples, French fries and table salt all have indices above 30 so to keep your food palatable and your diabetes in check, use the zero rated stevia.
  • Combats Hypertension and Candidiadis. The South Americans have used stevia for long periods to combat rising blood sugar levels, obesity and fatty liver, but it is only proven to lower the blood pressure of hypertension patients.

The yeast we hear about being in our bodies is called Candida albicans and it can ferment sugar in the body, causing the candidiasis infection with treatment involving cutting sugar out of your diet.  Stevia does not react with the yeast and can also keep your food sweet.

Stevia is a safer and healthier option to sugar.  It is natural and sweeter than sugar making it a great option to combat obesity and sugar level problems the world is constantly facing.


Resources:

//www.theglobeandmail.com/life/health-and-fitness/ask-a-health-expert/are-stevia-and-agave-syrup-healthier-sweeteners-than-sugar/article13204159/

//www.livescience.com/39601-stevia-facts-safety

//healthyeating.sfgate.com/sugar-vs-stevia-7658.htmlRead More

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The Dangers of Vegetable Oil
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Date: July 21, 2015 05:23 AM
Author: Darrell Miller
Subject: The Dangers of Vegetable Oil

More often than not, when we see the words vegetable oil, we assume that it is good for us since vegetables are essentially beneficial for the body. The truth of the matter is that this kind of oil is mostly derived from seeds such as sunflower, soybean and corn, not from any kind of vegetable at all. Aside from this, their extraction requires a process that uses up a lot of energy and is not good for the environment.

Vegetable Oil

Trans Fats

Unsaturated fats, otherwise known as trans fats, are fats that are usually solid at room temperature but processed in such a way that they are not when they come in the form of oils derived from seeds. These contribute to diabetes, heart disease, cancer and obesity. The sad part is that although there are so many calls to action regarding minimizing the presence of trans fats in food; there is very little that has been done regarding their presence in vegetable oils. How trans fats were developed or discovered will show how scary it actually is. It was discovered while looking for an alternative to tallow which is an ingredient for candle wax. It was cheap and convenient to harness and use. The reason why it is widely used is because of its extended shelf life. It can also be reused several dozen times for frying without changing flavor or adding a rancid taste to the food fried in it.

Mutated Fats

The process of extracting the oils from their sources requires a lot of heating and, for some, even exposure to acids and metals which contribute to the "mutation" that these oils undergo. Hydrogenated vegetable oil confuses our bodies into thinking that they are good for us. This is mainly due to the processes that changes their form. HVO alters the structure of our cells, making them weak and lowering the good cholesterol as well as raising the bad. Our bodies welcome these fats and do not treat them as a danger although their presence does, in fact, increase the risk of heart disease, diabetes and other diseases.

Imbalances

Vegetable oils can also cause imbalances in the composition of our fatty acids. Omega 3 and omega 6 fatty acids are not produced by our bodies. Therefore, we need to supplement these from our diets and daily consumption in pretty much the same amounts to balance their presence in the body. Polyunsaturated fats from HVO that causes the mutation in our cell membranes can lead to oxidative chain reactions which are harmful to our cells. In essence, our cells are made weak and the chances of alterations to our DNA are increased. Omega 6 is abundant in HVO because it helps to slow the deterioration of the vegetable oil. It can cause an imbalance to the cell membrane causing inflammation in various parts of the body. One component of Omega 6 that is highly dangerous is linoleic acid. It has been linked to obesity, high levels of bad cholesterol and even damage to the brain's hypothalamus.

These are just a few of the dangers that come with using so called vegetable oils. These dangers are kept under wraps because of the massive income that the food industry will lose if it changes the oils used for cooking and preparing food.


Read More

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Why Is Acai, Goji, Pomegranate, Noni And Mangosteen Called Super Fruits?
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Date: January 15, 2013 04:55 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Why Is Acai, Goji, Pomegranate, Noni And Mangosteen Called Super Fruits?

Health Benefits Of Super Fruits

"Super fruits" is an idiom that is frequently used to refer fruits that have extraordinary antioxidant and nutrient qualities and provides benefits over and above the basic nutrition. Exotic fruits such as acai berries, goji berries, mangosteen, noni and pomegranate have earned this distinguished status. These fruits have exceptional amounts of vitamins, antioxidants and phytochemicals that play a significant role in preventing various diseases.

Each of these super fruits restrains its own distinctive set of properties that prove to be extremely beneficial for the overall health of the body.

Health Benefits Associated With Super Fruits:

Acai Berry:

Acai berry is a rich source of dietary fiber, protein and a compound called anthocyanins. It also includes high levels of omega-6 as well as omega-9 fatty acids, which are believed to have a protective effect on the cardiovascular system and heart. In addition, the anthocyanins compound present in the acai berry helps in lowering the blood cholesterol level.

Mangosteen:

This fruit is abundantly grown in south Asian and due to its fine flavor it is also referred to as "The Queen of Fruits". Mangosteen retains high levels of phytochemicals known as xanthones that offer this fruit a unique medicinal property which is not found in other common fruits. Mangosteen also includes other powerful natural compounds such as polysaccharides, catechins, quinones, polyphenols and stilbenes. Each of these compounds are believed to be effectual in preventing diseases such as, osteoporosis, atherosclerosis, high blood pressure, kidney stones, glaucoma, cataract, Alzheimer's, neuralgia etc. The fruit is also used to treat aging, depression, obesity, allergies, skin diseases, ulcers, fevers, diarrhea and pain.

Noni:

Noni juice is known to restrain more than 150 nutrients, including protein, all the essential amino acids, vitamins A, B1, B2, B3, C and E, minerals such as iron, calcium, magnesium, selenium and potassium, polysaccharides, phytonutrients and digestive enzymes. Noni is one of the most unique super fruits. Noni juice can help to normalize blood sugar levels; decrease inflammation, arthritis and joint pain; enhance digestive function, cleanse colon, remove parasites; reduce irritable bowel syndrome, diarrhea, constipation and menstrual cramps; prevents gastric ulcers; relives pain, mental depression and atherosclerosis.

Goji Berry Juice:

This miraculous berry is rich in polysaccharides. It also includes fiber, 18 amino acids, 21 minerals, Vitamins A, C, B, & E, protein and Omega-3 and Omega-6 fatty acids. Goji juice is a potent antioxidant that prevents premature aging. It also stabilizes molecules called free radicals that damage the DNA and gives rise to several diseases. Moreover, Goji juice helps in reducing the risk of cancer by averting DNA mutation, curtailing growth of tumors and by managing the peroxidation of lipids. This distinctive fruit helps to relieve insomnia and headache, improve functions of the heart, assist in digestion, aid to regulate weight, promote sexual health, improve fertility, enhance memory functions, and alleviate dry cough.

Pomegranate:

Pomegranate is one of the oldest known super fruits. It is rich in vitamins A, B and C, potassium, magnesium, phosphorous, calcium and sodium. Pomegranates are very high in dietary fiber which boosts the digestive system. Additionally, medical evidences reveal that a unique amalgamation of polyphenols found in pomegranate helps to lower LDL or bad cholesterol in the blood which eventually benefits the heart. Moreover, pomegranate's natural antioxidant and anti-inflammatory properties aid to slow down the development of cancer especially, prostate and lung cancer.

Overall, super fruits are extremely valuable for our body due to its high anti-oxidant and nutrient content that helps to reinforce the body's natural defenses and make it healthier and less prone to most type of diseases.

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2812)


Grape Seed or Pine Bark Extract, Which Is Best?
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Date: October 27, 2011 07:26 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Grape Seed or Pine Bark Extract, Which Is Best?

Pine Bark Vs Grape Seed Extract

Pine Bark Extract and Grape Seed Extract are two well known products that are effectual in combating ADD. Pycnogenol however, is more expensive since it is a patented form of pine bark extract that is being sold in many health stores world-wide. The potent properties of both Pycnogenol and Grape Seed Extract are their proanthocyanidins or flavan-3-ols contents that are normally found in fruits and vegetables. The reason why these chemicals are beneficial is their capacity in aiding vitamin C to work better for the brain. Vitamin C is essential for the production of norepinephrine, serotonin, and dopamine (neurotransmitters involved in ADD). Vitamin C is also useful in providing the body with antioxidants that can help fight free radicals that are very injurious for your health and may lead to a dreadful disease such as cancer. In addition, another role of vitamin C in the body is its capacity to aid the body in chelating detrimental toxic heavy metals by flushing them out from the body.

Pine Bark Extract and Grape Seed Extract are also effective natural anti-histamines anti-inflammatory agents and immune boosters. Both extracts are also proven to be influential in terms of regulating enzymes that have significant effects in metabolism. Since the extracts are able to inhibit the breakdown of dopamine and norepinephrine, then it will also lead to a faster reuptake of dopamine.

Active Ingredients

Proanthocyanidins has been the subject of interest by many researchers in the scientific investigations that they have conducted because of its promising effects that could treat various venous conditions. The compound has been proven to be effectual in strengthening the walls of your capillaries, arteries and veins hence, is very useful in protecting you from ailments that involves the mentioned vital body parts.

The benefits of Pine Bark and Grape Seed are already published in many health magazines worldwide as well as in many TV shows like the 60 minutes. The antioxidant content of the extracts derived from Pine Bark and Grape Fruit contains liberal amounts of antioxidants that also acts as an antimugenic agent hence, could prevent DNA mutation. Since the extracts have such innate capability of inhibiting the mutation of DNA, it can be a cure to many chronic degenerative diseases that are caused by environmental mutagens.

Another benefit of OPCs is its relevant effects on peripheral venous insufficiency. This specific problem in the legs causes so much pain and discomfort which could also lead to disability. With OPC, relevant improvement in the condition could be noted as evidenced by a decrease in the pain felt, edema and cramps.

Comparing both extracts in terms of efficacy is so difficult to determine because Pine Bark Extract and Grape Seed Extract has similar components that are all beneficial to one’s health. The compounds that both extracts have are very useful to one’s health therefore comparing the two would be rootless considering all the health benefits that both extracts could offer.

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Boost Brain Chemistry, Lower Bad Cholesterol, And More
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Date: May 12, 2011 01:27 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Boost Brain Chemistry, Lower Bad Cholesterol, And More

What is Inositol Good for?

Inositol is an organic compound present in many plant-based foods. Popular nutritional sources of inositol include brown rice, wheat bran, whole grains, beans, nuts, and other foods rich in fiber. It is a polyphosphorylated carbohydrate that was once classified as an essential nutrient together with B-complex group of vitamins. It is an important component of signal transduction of cells, amplifying the strength of signals from the receptors on the cell surface to target molecules within the cytoplasm.

Cancer research on inositol is one of the most publicized. Fruits and vegetables that are known for their high fiber content also contain large amounts of inositol, which is believed to prevent the inactivation of DNA repair gene and protect the cells from mutation that lead to carcinogenesis. In laboratory studies it has shown great medicinal potential as a therapeutic remedy for various cancers. In addition, it has been extensively utilized in the treatment of psychiatric disorders.

Rebalances Brain Chemicals

Supplementation of high dose inositol has been observed to be beneficial to sufferers of mental illnesses. There have been numerous clinical trials focused on its effects on the chemical compounds found in the central nervous system, and early studies recorded that its mechanisms of action are similar to a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs.

A growing body of scientific literature is devoted to its purported role in the amelioration of anxiety disorder, panic disorder, obsessive-compulsive disorder, clinical depression, and bipolar disorder. It has been favored over some SSRIs because of its desirable results and absence of side effects. It has particularly benefited individuals diagnosed with obsessive compulsive disorder, with testimonies being largely positive. Also, it has been reported to also reduce frequency of panic attacks.

Lowers Bad Cholesterol

High-fiber diet has always been recommended to manage high cholesterol levels. It emphasizes the intake of whole grains, fruits, and vegetables. The same group of foods is rich in the carbohydrate inositol. In the latter half of the 20th century, it was discovered that inositol in fact contributes to the breakdown of fatty molecules, such as triglycerides, in the gastrointestinal tract and interferes with their absorption. More importantly, regular consumptions of inositol appear to reduce overall lipid levels in the blood. It is postulated that it blocks the metabolic pathway that integrates triglycerides in very-low-density lipoproteins, the immediate precursors of low-density lipoproteins, also known as bad cholesterol. By so doing, it not only lowers cholesterol and free fatty acids found in systemic circulation but also prevents cardiovascular diseases, such as atherosclerosis.

Other Benefits

Many nutraceutical products that contain inositol are commercially touted to aid weight loss. Inositol has also been associated with the alleviation of digestive problems, most notably constipation. It is believed to soften the stool by attracting water as it works its way into the alimentary canal, and regular intake promotes regularity. Furthermore, it has been linked to hair growth as low levels of inositol have often been tied to hair loss.

Taking a inositol supplement can help you obtain all the inositol you need for your daily needs!

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Can a Lactase Enzyme Help with Milk Digestion
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Date: April 27, 2011 03:49 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Can a Lactase Enzyme Help with Milk Digestion

Lactase enzyme is the compound necessary for the breakdown of lactose. As such, deficiency in this enzyme results in the impaired capacity to metabolize milk and other dairy products. This is quite common in Asian and African countries, where the majority of their populations do not rely on milk-based animal products. Consumptions of lactase supplements have been reported to aid milk digestion.

Lactose Intolerance

Human beings are believed to have lost the ability to process lactose in adulthood a few thousand years ago. The primary source of lactose of early human populations was breast milk, which is only provided by mothers during the early stages of childhood in general. This practice has continued in Asian and African communities, the reason why these groups are predominantly lactose intolerant.

On the other hand, European communities have considered milk as an important source of food and nutrition since the introduction of the agricultural practices of raising livestock. It is now postulated that the early inhabitants of Europe who relied so much in dairy products underwent a genetic mutation that enables them to continue the biosynthesis of the enzyme lactase into adulthood.

Lactose Maldigestion

Whereas much of the global population is lactose intolerant, people with European ancestry are capable of digesting milk well into their adult years. That being said, people who are not lactose intolerant are not necessarily well equipped for the digestion of dairy products. In fact, many adults suffer from lactose maldigestion, which causes gastrointestinal problems like diarrhea and indigestion as well as allergies and sinus problems such as infections.

Lactose maldigestion has a higher incidence worldwide than lactose intolerance. It is a fact that the genetic expression for the enzyme lactase as produced and released in the digestive tract is down-regulated the human body with age. This may not result in lactose intolerance, but depleting levels of lactase will no longer be able to effectively digest into old age food products that contain lactose.

Lactase Supplements

The absence of the enzyme lactase may result in a variety of digestive problems when milk is taken together with other foods. In some people, even the smallest amounts of lactose upset digestion and produce common symptoms of lactose intolerance such as indigestion, diarrhea and sinus inflammation. If you want to avoid these problems but still love dairy products, you may want to choose hydrolyzed lactose.

Lactase supplements have been documented to produce desirable results. Most nutraceutical companies make use of eukaryotic microorganisms that possess the genes needed to synthesize this enzyme, such as Kluyveromyces fragilis, Kluyveromyces lactis, Aspergillus niger, and Aspergillus oryzae, among others. These supplements are formulated for individuals with lactose intolerance, but also benefit those who are suffering from symptoms tied to lactose maldigestion.

The enzyme lactase works on the principle of breaking down lactose into smaller compounds, galactose and glucose, and supplementation of lactase does exactly that.

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Turmeric, Curcumin, And Good Health
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Date: November 11, 2010 03:48 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Turmeric, Curcumin, And Good Health

turmeric Leaves

Turmeric and its history

Turmeric is not just an ancient Asian spice but also an effective traditional alternative medicine used worldwide. Turmeric is a spice that originates in India and has been long used in both Ayurvedic and Chinese traditional medicine. This spice comes from the herb Curcuma longa L. which is a member of the Curcuma botanical group, a part of the ginger family of herbs called Zingiberaceae. The root and rhizome (underground stem) of this plant is crushed and powdered into ground Turmeric. Ground Turmeric is used worldwide as a seasoning and the main ingredient in curry powders. Ground Turmeric is also the source of Curcumin, an extracted potent substance also used as alternative medicine nowadays.

Turmeric, because of its Curcumin content, has many health benefits to humans. Firstly, Turmeric has an anti-inflammatory property. Its active ingredient, Curcumin, has been proven to help reduce inflammation. Decade to decade, Turmeric has been used as an anti-inflammatory agent to treat inflammations of the skin and muscles. Experiments done by researchers also revealed that this herb has been effective in decreasing post-surgical inflammation. This important health benefit of Turmeric is considered to be a result of the herb’s ability to slow down, if not to totally stop, Eicosanoid Biosynthesis, one of the processes the immune system undergoes during an inflammatory response.

Secondly, as a result of its anti-inflammatory characteristic, Turmeric also has an anti-arthritic property. It is widely used as an alternative medicine for rheumatoid arthritis and other autoimmune disorders. In addition, this herb also has a natural painkiller effect. Studies show that it has similar actions to the commonly used medications such as COX-2 inhibitor and Nonsteroidal Anti-inflammatory Drugs.turmeric root

Thirdly, several studies have shown that Turmeric is also helpful in lowering the level of bad cholesterol in the blood known as the Low Density Lipoprotein or LDL and in increasing the body’s good cholesterol, High Density Lipoprotein or HDL. An increased level of LDL promotes cholesterol plaque deposits to the walls of blood vessels, most commonly in the arteries of heart. These plaques narrow the arterial diameter hence resulting to high blood pressure and even circulation blockage. An arterial block may cause poor circulation and oxygenation to heart muscles leading to cardiac injury then infarction. This is oftentimes the cause of heart attacks. It has also been discovered that Turmeric can promote excretion of dietary fats. Thus, controlling the intestinal uptake of fats, especially cholesterol.

Turmeric - Powerful Antioxidant

turmeric powder Lastly, Turmeric is also widely used because of its anti-oxidant property. Studies demonstrate that Turmeric is effective in eliminating free radicals in the body. These free radicals are harmful. It may cause cell mutations which can lead to tumor formation and, worse, cancer.

This herbal plant can be prepared in the household by pounding and pressing its roots to be able to extract the juice out. It is then mixed with water and may be used topically or by nasal inhalation. The root can also be lightly cooked and eaten. Turmeric is also helpful in earaches and to clear clogged sinuses thus easing breathing. This herb can also be purchased in bulk powder or standardized forms to ensure its beneficial properties are intact.
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Pine Bark Extract
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Date: October 07, 2009 11:25 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Pine Bark Extract

Pine Bark PictureMany Native American tribes relied on the bark of pine trees for its ability to treat a number of disorders. The Annedda pine was called the “tree of life” due to its marvelous healing benefits. Jacques Cartier, a noted explorer in 1535, wrote in his diaries about the early medicinal uses for pine tree bark. Cartier and his crew came down with scurvy after being caught in the bitter snows of Quebec and living on hard biscuits and cured meat. Multiple men died before Quebec Indians approached them and made a tea from the bark of a pine tree. After drinking the tea and applying poultices to their wounds, they were soon healed. The miraculous recovery is actually a result of the vitamin C and bioflavonoids in the bark. A French professor discovered Cartier’s account and became intrigued with studying pine tree bark. He isolated a certain kind of proanthocyanidin flavonoids from the extract and later found it to have antioxidant attributes.

Pine bark extract has become an important herbal remedy due to its antioxidant power. It is responsible for binding with collagen fibers and helping to restore elasticity in the skin. It also protects the body from free-radical damage, which prevents excess and premature wrinkles. Pine tree bark also protects capillaries from free-radical damage that can cause phlebitis, varicose veins, and bruising. Those people who are suffering from skin conditions like psoriasis can also be benefited from pine bark extract. Along with being an antioxidant, pine bark is a natural anti-inflammatory. It helps heal joint pain that is associated with things such as arthritis and sports injuries. This herb helps to control and prevent edema and bursitis. Pine Bark Picture Pine bark extract also helps with eyesight. It is responsible for reducing the risk of and treating diabetic retinopathy. Multiple studies have concluded that it is beneficial in improving night vision. One study even found marked improvement in visual performance in the proanthocyanidin group over a placebo group.

Additionally, pine bark extract may also help in inhibiting cellular mutations like tumors. Reports have found that this herb can help to prevent cellular deterioration in breast tumors and cardiovascular disease. There is also evidence that this herb possesses antiulcer properties that may help prevent the formation of undesirable chemicals in the stomach.

Pine bark can also benefit other conditions with its proanthocyanidin therapy. Among these are autoimmune disorders such as lupus, neural problems such as Parkinson’s disease and multiple sclerosis, and vascular problems like heart disease, atherosclerosis, and stokes. Pine bark extract can also treat common complaints such as insomnia, flu, and even the common cold. This herb is very helpful in improving memory, longevity, and the prostate.

Additionally, its stimulant properties are responsible for decreasing the production of histamines in allergic reactions like hay fever. In order to obtain the best results when supplementing with this, or any herb, it is important to consult your health care provider before beginning any regimen. For more information on the many beneficial effects provided by pine bark extract, please feel free to consult a representative from your local health food store with questions.

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Turmeric Extract (Curcumin)
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Date: February 10, 2009 01:18 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Turmeric Extract (Curcumin)

Curcumin is a potent antioxidant and anti-inflammatory that has the potential to provide far-reaching health benefits. It has been shown to be helpful in rheumatoid arthritis, inflammatory bowel disease, pancreatitis, Alzheimer’s disease, heart disease, diabetic retinopathy, and cancer. All of these diseases share underlying inflammation that curcumin may help to diminish.

If you have ever eaten curry or cooked with the spice turmeric, you’ve consumed curcumin. It is obtained from the roots of Curcuma longa and consists of several curcuminoids. Turmeric is biologically related to ginger. Curcumin works as an antioxidant, boosting levels of glutathione S-transferase, which is one of the body’s principal antioxidants. This antioxidant blocks the formation of prostaglandin E2, which is a compound that promotes inflammation within the body. Curcumin also inhibits two inflammation-promoting enzymes: COX-2 and 5-LOX. Additionally, curcumin is able to prevent mutations to DNA, which is an effect that helps to maintain younger, healthier cells.

A study conducted at the University of Arizona Health Sciences Center in Tucson had researchers using a curcumin rich turmeric extract to treat rheumatoid arthritis in laboratory animals. The extract blocked joint inflammation as well as the breakdown of joint cartilage and bone. It did this by inhibiting the genes that are involved in inflammation. Curcumin also holds tremendous promise in preventing cancer, as well as an adjunct treatment. Studies on animals have found that curcumin can protect against colon, intestinal, oral, and skin cancers. Its benefits come from several mechanisms. First of all, it blocks the cell-growth cycle in cancer cells, which eventually leads to destruction. It also reduces free radicals and inflammation, both of which can lead to cancer-causing cell mutations.

Many studies have found that curcumin can protect the liver against a variety of toxic compounds, which is important news for those people who are suffering from liver diseases like hepatitis or cirrhosis. In a recent study, researchers reported that curcumin increased the clearance of creatinine and urea, which are signs of improved kidney function. Additionally, curcumin reduced liver damage from toxic chemicals and excess iron.

Another study found that curcumin has the ability to inhibit the activation and spread of the liver cells that play a role in the development of cirrhosis. Japanese doctors have recently used curcumin, drugs, or placebos to treat 89 patients that have ulcerative colitis. These doctors found that a combination of curcumin and conventional medications resulted in the greatest benefits over six months of treatment. Patients in this study took 1,000 mg of curcumin after breakfast and again after dinner.

Inflammation is the underpinning of all chronic degenerative diseases, making curcumin likely to be beneficial for many different conditions. So far, research has identified curcumin’s benefits for diabetic retinopathy, lung disorders, and skin problems such as psoriasis. A dose of 3.6 g of curcumin reduced PGE2 levels by two-thirds in only one hour. After consuming curcumin daily for one month, PGE2 levels were 57 percent lower than before supplementation began.

Turmeric has been used as a culinary spice for at least 2,000 years. It was listed in an Assyrian herbal in 600 BC, used by ancient Greeks, and widely recommended in Ayurvedic medicine. Native to India and other regions of South Asia, it may reduce the risk of Alzheimer’s disease and help maintain mental function. Curcumin is safe in amounts of 500 to 8,000 mg daily, with most supplements providing 500 mg of curcumin.

Turmeric has been proven safe in larger amounts, but is usually limited by taste as a spice. One should look for a standardized supplement that contains at least 90 percent curcumin. Standardized Turmeric can be found at your local or internet health food store.

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Red Pepper, Cayenne, Capsicum
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Date: December 18, 2008 04:51 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Red Pepper, Cayenne, Capsicum

A remarkable whole body stimulant, Capsicum can boost blood flow, tone the nervous system, relieve indigestion, promote sweating, help to cauterize and heal ulcers, ease persistent pain, and fight off infection. One study on African plants found that Capsicum, when regularly ingested, is highly beneficial in hemorrhoids varicose veins, anorexia, liver congestion, and vascular conditions. The therapeutic actions of capsicum can be attributed to the alkaloid or glucoside content of the herb.

Capsicum boosts peripheral circulation and stimulates organ secretion as it expedites the therapeutic delivery and action of other herbs. This allows the medicinal benefits of these herbs to reach the inflamed tissue more rapidly because of enhanced blood flow. Cayenne insures rapid and even distribution of the active parts of the rest of the herbs to critical parts of the body, which include those that are involved in cellular respiration, metabolism, data transmission, and neural-hormonal activation.

For this reason, cayenne is included in many other blends, as even extremely small quantities can dramatically increase the efficiency of most other herbs. Capsicum stimulates everything from blood flow to peristaltic action in the stomach, to intestinal transit time. Capsicum’s ability to stimulate organ secretion and heart action makes it one of the strongest natural stimulants that are known.

Capsicum is also known to be unequaled in its ability to boost circulation and increase heart action. Cultures that consume significant amounts of cayenne pepper in their diets have been found to have lower rates of cardiovascular disease. A variety of desirable actions on the entire cardiovascular system can be produced by Capsicum, with its extraordinary ability to enhance cardiovascular performance and lower blood pressure. Capsicum is considered a superior food for the heart by herbalists, where capsicum in hot water is thought to help lessen the severity of heart attacks.

Many studies have also been done on Capsicum’s ability to reduce the risk of developing atherosclerosis by reducing blood cholesterol and triglyceride levels. When cayenne is ingested along with dietary cholesterol, the typical rise in liver and blood serum cholesterol levels that ordinarily results was significantly inhibited. Additionally, bile acids and free cholesterol were subsequently eliminated from the body through the stool.

Another bonus of Capsicum is its ability to lower blood serum cholesterol, as it decreases blood pressure. There is additionally evidence that suggested that the herb is able to initiate other mechanisms that help in fighting hypertension. Because Capsicum stimulates organ secretion and boosts peripheral blood flow, it is not shocking that is also facilitates the faster removal of toxins from the blood stream and lymphatic system.

Additional benefits of Capsicum include its ability to boost the circulatory system, as it has the ability to help in preventing cold hands and feet, as well as Reynaud’s Syndrome. Capsicum also has antioxidant capabilities, making it a great scavenger of free radicals. Anti-cancer research has also found that Capsicum does demonstrate anticancer properties, as it inhibits certain enzymes that initiate the mutation of cells. This implies that taking Capsicum can give the body some protection against cellular mutation.

Capsicum has also been found to be an impressive pain killer, an anesthetic to ulcerated tissue, an aid in weight loss, a helper in psoriasis and rhinitis, and a reliever of fevers and chills. The list goes on and on, about the benefits of this amazing herb. Cayenne or red pepper can be found at your local health food store.

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Polyphenols is an Antioxidant
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Date: October 13, 2008 02:14 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Polyphenols is an Antioxidant

A lot of new evidence suggests that consuming more plant polyphenols is a powerful way to protect aging arteries. These polyphenol compounds help improve endothelial function, a critical factor in preventing atherosclerosis; inhibit abnormal platelet aggregation which causes most sudden heart attacks and strokes; fight inflammation; and support healthy blood lipids. Polyphenols that are of particular interest are those derived from green tea, cocoa, apples, and black chokeberry, which all complement each other in helping to build the body’s defenses against various ailments.

All throughout history, the medicinal potential of plants has been celebrated. Modern science has found that edible plants are to be valued for their high vitamin and fiber along with their rich store of polyphenols. Polyphenols are found in fruits and vegetables, as well as cocoa, tea, and chokeberry and have been shown to be a type of chemical that may protect the body against some common health problems as well as certain effects of aging. Polyphenols protect cells and body chemicals against damage that is caused by free radicals and block the action of enzymes that cancers need for growth, deactivating substances that promote the growth of cancer. The increased consumption of polyphenols has been associated with a reduced risk of cardiovascular disease and potentially cancer and stroke.

In Aztec culture, cocoa was one of the most highly prized due to its medicinal and stimulant value, along with its taste. The polyphenols found in cocoa occur in a higher concentration than can be found in any other food. They also have antioxidant activity much greater than those found in broccoli or red wine. The catechins and procyanidins that are found in cocoa seem to lower the risk of cancer and heart disease. Cocoa has also been proven in studies to reduce blood pressure, improve insulin sensitivity, and slightly ameliorate the lipid profile. Although cocoa is a healthy and tasteful food, it is high in caloric content and therefore, its ingestion must be accompanied by the careful reduction of calories from other sources.

Many studies have shown that tea polyphenols can be extremely beneficial to human health, possessing anti-obesity, antihypertensive, anti-diabetic, antioxidant, anti-inflammatory, and anticancer effects. Tea is the world’s second most consumed beverage, although less popular in the Western diet. Green tea and white tea retain more polyphenols in their intact form, as oolong and black teas undergo more extensive processing before they are marketed. Tea polyphenols break down in high temperatures therefore; freshly brewed tea contains a higher amount of polyphenols per serving than do tea drinks that are canned or bottled.

Similar to the blueberry, the black chokeberry is high in anthocyanins and antioxidant activity. It is native to eastern North America and has become popular in Eastern Europe and Russia due to its health-promoting potential. This berry protects the liver from chemical poisoning and the stomach lining from ulcers. It also acts as an anti-inflammatory, lowers harmful cholesterol levels, and prevents dangerous swings in blood pressure. Some studies have shown that this berry seems to prevent the harmful mutations in cell cultures, regulates immune function of human white blood cell cultures, and suppressed the growth of human colon cancers.

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Antioxidants
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Date: August 14, 2008 09:35 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Antioxidants

Antioxidants are the body’s main defense against free radicals as they work against the substances that create oxidants and the reactive substances that result from oxidation and reduction. Antioxidants neutralize free radicals by supplying the missing electron so that the molecule may be stabilized. There are many different types of antioxidants ranging from dietary antioxidants to those that the body produces itself. The four major antioxidant nutrients are vitamin A (beta carotene), vitamin C, vitamin E, and selenium.

Vitamin A, the first vitamin to ever be isolated, is essential for the proper function of the eyes and maintenance of the skin. It is found in the retina of all mammals as well as the liver. Vitamin A works to increase our resistance to infections by keeping all the linings in the body healthy. It is necessary for the health and moisture of the skin and the specialized cells lining the eyes, nose, mouth, throat, lungs, esophagus, stomach intestines, and urinary tract. When these cells don’t have sufficient vitamin A, they thicken and harden, which is extremely detrimental to health and makes us more susceptible to infection. Vitamin A also protects the body from cardiovascular disease and cancer, and is necessary for new cell growth, something that is extremely important in slowing the aging process.

Beta carotene is the best known of the two carotenoids that form vitamin A, being composed of two vitamin A molecules that are split apart by liver enzymes when the body is low in vitamin A. If body levels are sufficient, the enzymes remain inactive and beta carotene does not divide, making it a safe source of vitamin A, without producing the toxic effects that come with high levels of vitamin A itself. If excess beta carotene is consumed it is stored in fat tissue or circulated in the blood. Beta carotene is one of the most powerful antioxidant nutrients as it can prevent free radical formation and inactivate existing free radicals. Once free radicals have been formed, it traps them and breaks the chain reaction that occurs.

Vitamin C holds a crucial role in many body processes that are necessary for life, among these being its role in collagen formation. Collagen is important in the every structure of the body, as it works like glue to bind cells together to form tissues. The integrity of collagen depends on vitamin C. Vitamin C also functions as one of the most powerful free radicals to prevent the damage that contributes to aging and age-related diseases.

It also works against pollution and toxins that damage cells and cause mutations, possibly even reducing some food carcinogens and protecting lung lining fluids against damage by air pollution. Vitamin C is important in the immune system and it also increases immunity to infectious diseases, lowers total cholesterol, enhances the effect of vitamin E, promotes wound healing, growth, tissue repair, and helps with the utilization of iron.

Vitamin E prevents aging by prolonging the useful life of cells found in the body. It also works to protect vitamin C and vitamin A from free radical activity so that they may remain potent. Vitamin E has the ability to stop a free radical chain reaction as it is happening and plays an extremely important role in preventing the per-oxidation of lipids (cholesterol). It protects the cell membrane, which in turn causes it to help protect the body from disease.

Selenium, one of the ten essential trace minerals, can be found in all tissues of the body. It is best known for its antioxidant role and its function in fighting cancer. It protects the liver from damage and works to stop lipid per-oxidation. Selenium is vital in maintaining the elasticity of body tissues and preventing the oxidation of fatty tissue, in turn combating the effects of aging. Selenium causes the skin to be healthier, muscle mass and tone are more easily maintained, and the heart is strengthened. Selenium works along with vitamin E, enhancing the effects of each other. It is important to get our vitamins and minerals on a daily basis to maintain a health happier life.

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Protect Your Skin
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Date: August 11, 2008 03:20 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Protect Your Skin

SOD, which is short for superoxide dismutase, is an antioxidant that is found in small, insubstantial quantities in the body. It reduces potentially harmful free radicals. Research is also available that looks into antioxidants role in supporting healthy skin against the sun. However, SOD’s benefits have only recently begun to be studied. One studied found that SOD supported skin health against the photo-oxidative stress that is caused by UV radiation better than any other antioxidant.

Two studies have found that the oral consumption of carotenoids from tomatoes such as lycopene, phytoene, and phytofluene helps to maintain healthy skin by protecting it against the damage induced by UV rays. Topical application of currently available sun care products provides limited protection against UV light, as even so-called quality products allows some light to still penetrate the skin which causes damage and wrinkling. To provide optimal protection, supplementing the diet with natural antioxidants, especially lycopene, is essential along with applying sun care products that contain UV-B and UV-A filters. Many studies have been done to examine the photo-protective effects of lycopene.

It has been shown that this nutrients decreases reddening of the skin. A second study, which involved three groups of antioxidants and two different groups of antioxidant supplements that contained carotenoids and selenium, tested the impact of these nutrients on skin structure and health. After 12 weeks, a significant increase in skin density and thickness, an improvement in skin smoothness and softness, and reduced scaling were the results of using these nutrients. There are many all-natural extracts that contain lycopene, and a complex of tocopherols, beta-carotene, phytoene, and phytofluene. These supplements increase the levels of antioxidants in the skin, which enhances the body’s natural defenses against UV-induced skin damage, supports healthy skin structure, and helps to prevent premature aging of the skin.

Zinc oxide is said to provide the most abundant wavelength protection of any sunscreen ingredient, which uniformly covers from 290 to 300 nm, allowing it to protect against UV-B and most of the UV-A rays. Recent studies have shown that topical vitamins C and E offer greater photo-protection than what was previously realized, delivered protection four times stronger, offered seventy percent sunburn reduction, and prevented the formation of thymine dimmers, which are signature DNA mutations found in non-melanoma skin cancers.

Actually, a study that was published in the Journal of the American Academy of Dermatology determined that a combination of topical vitamins C and E were better for UV protection to skin than an equivalent concentration of topical vitamin C or E alone. Additionally, the combination of vitamins C and E provided protection against thymine dimmer formation. In order to obtain appreciable photo-protection, a combination of topical vitamins C and E is necessary.

Medical experts also suggest that all of the above natural products may protect against skin cancer, photo-aging and the effects that go along with them. For more information on these nutrients and the helpful capabilities that they are able to provide for your body, be sure to contact your local health food store. Sun Care Moisturizers And Creams

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Antioxidants For The Body
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Date: June 10, 2008 11:27 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Antioxidants For The Body

Eating the fruits and vegetables that naturally contain antioxidants is the best way to get them into your system. Mixing them into a well-balanced and healthy diet is the best method of all. This way you reap the benefits of all of the antioxidants in a natural combination.

The benefit of dietary antioxidants is that they slow the chemical process of oxidation. This oxidation is what causes narrowing of the arteries and heart-related health problems due to cholesterol deposits. Eating a regular variety of herbs, vegetables and fruits that contain antioxidants is the best way to maintain good health. Some foods that contain antioxidants include:

* Tomatoes
* Garlic
* Onions
* Rosemary
* Grapes
* Pomegranates

Antioxidant supplements are available, lab testing have shown that they are just as effective as their natural counterparts. Natural foods contain ranges of antioxidants that work together synergistically. These combinations of antioxidants are much more effective.

More Benefits:

Antioxidants and other nutrients are needed by the body to protect against cell damage. They also may reduce the risks of certain forms of cancer.

It has been discovered that the mitochondria (cell power plants) are a major source of oxidant production. They are also a target for the damaging effects of the very oxidants that they produce. This is a major cause in the advancement of cellular aging, called apoptosis.

It is believed that in apoptosis, each cell has a fixed number of cell divisions that it is capable of. After the cell has used its allotted number of divisions, it ceases to function. Oxidative damage is also a contributing factor of DNA mutation, which causes further malfunction of the cells.

Most Common Antioxidants:

The following is a list of the most common antioxidants, what benefits they offer and where to find them:

*Beta-carotene keeps the skin healthy and promotes growth and development of bones. It also helps to prevent night blindness and fight infection. Beta-carotene is found in vegetables and fruits: carrots, cantaloupe, apricots, broccoli, peppers, tomatoes, spinach, sweet potatoes and pumpkin.

* Vitamin C destroys free radicals inside and outside cells. It helps in the healing of wounds, preventing bruising, formation of connective tissue, iron absorption and keeping gums healthy. Vitamin C is being studied for its beneficial effects in reducing cataracts, cancer and heart disease. Foods high in vitamin C include tomatoes, citrus fruits and juices, berries, mango, papaya, peppers, cabbage, spinach, broccoli and potatoes.

* Vitamin E acts as the essential fat protector in cell membranes and red blood cells. It reduces the risk of heart disease, cancer and other diseases associated with age. Vitamin E is found in peanut butter, nuts, seeds, vegetable oils, margarine, whole grains, wheat germ, salad dressings and avocado.

* Selenium helps the body maintain healthy hair and nails. It also enhances immunity and, along with Vitamin E, prevents cell damage. Vitamin E reduces the risk of cancers, especially prostate, lung and colorectal. The best sources of Selenium include brazil nuts, garlic, meat, eggs, poultry, seeds, seafood and whole grains. The amount of selenium found in plants depends on the soil content in which they are grown.

Antioxidants benefit the body by providing a layer of protection for the tissues and cells. They are the front line of the body's protection against free radicals. Free radicals are unstable by-products of oxygen that cause premature aging and degenerative diseases. They also come from environmental sources, such as pollution, UV rays and other toxins. Foods rich in antioxidants help to clean free radicals from the body. They also help to prevent various age-related diseases, cancers and heart disease.

Maintaining a healthy, nutritionally balanced body that has the ability to fight disease and infection is a prime way to live a long, disease free and happy life. Regular ingestion of antioxidant rich foods or supplements is the best method to achieve this.

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Copper
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Date: May 15, 2008 01:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Copper

Copper is an essential trace mineral necessary for life, and it is necessary for the proper function of certain enzymes that allow certain biochemical functions of the body to take place. Without copper neither plant nor animal life would be possible.

Dietary sources include nuts, grains, seeds, beans and other vegetable protein sources. Although it is also obtained from animal sources, these tend to be rich in zinc, and for reasons that will be discussed shortly, the presence of zinc can deplete copper absorption. Other common sources are copper cooking utensils and drinking water from copper pipes. After digestion, copper is absorbed into the body through the stomach and the small intestine. It is also possible for copper to be absorbed through the skin from copper bracelets.

Once absorbed, copper is bound to albumin and taken by the blood to the liver, where it is bound to a plasma protein known as ceruloplasmin. Among the enzymes with which copper is associated as a ‘helper’ are Cytochrome C oxidase, used in the conversion of glucose to energy, Dopamine hydroxylase, an essential component in the biochemical production of adrenaline, and superoxidase dismutase, that protects against the oxidative damage of cell tissue. Of particular benefit are its anti-inflammatory and antioxidant properties, and its role in energy production. Because of its antioxidant effect, copper could well play a very important role in protecting against atherosclerosis, and cardiovascular disease, the ravaging effects of free radicals on body cells and also certain forms of cancer.

Copper is also important in electron transport, and is responsible for the blue coloration of the blood of most molluscs and many arthropods. This is because rather than hemoglobin, these animals use the copper-based hemocyanin for oxygen transport in the blood. Rather than the iron-containing hemoglobin making the blood of these creatures red as it is with mammals, theirs is blue due to the hemocyanin. Copper salts are generally green and blue, as are the blue copper proteins plastocyanin and azurin.

So how is copper used by the body? It is, after all, fairly toxic, as little as 30 grams being fatal to humans, bringing on similar symptoms to those of arsenic poisoning. It is in fact the reason for its toxicity that also renders it so useful to the body. The toxicity is largely due to the ability of copper to accept and donate electrons as it changes between oxidation states. This results in the generation of very reactive radicals that can cause severe oxidative stress. The complete reason for its toxicity has yet to be determined, but the stress caused to body cells by free radical oxidation is a very serious condition.

It is this rapid change in its oxidation state that is valuable to the enzymes with which it is associated. The ceruloplasmin is responsible for most of the transport of bivalent copper around the body, in the tissues of which it helps to form the bivalent copper enzymes previously mentioned, such as Cytochrome C oxidase and Lysyl oxidase. In doing so the copper is converted to the monovalent state.

It also helps to aid in the production of the strong antioxidant Superoxide dismutase (SOD). What this enzyme does is to catalyze the formation of oxygen and hydrogen peroxide by the dismutation of superoxide, a negative ion consisting of two oxygen atoms and a free electron, and hence a very powerful free radical. Dismutation is the simultaneous oxidation and reduction of the species, rendering the free radical relatively harmless. This type of action on free radicals is a very powerful one, and essential in the body’s fight against such free radical species that are so dangerous to animal cells.

SOD exists in more than one form, and can also contain zinc, manganese and nickel in addition to copper. The internal fluid (cytosol) of practically all eukaryotic cells (cells containing a nucleus) contain a form of Superoxide dismutase dependent on copper and zinc, while most mitochondria contain an SOD with manganese.

Another of the important uses that your body can find for copper lies in the production of hemoglobin. This is because copper is needed for the storage and release of iron to produce hemoglobin, the protein in red blood cells. It is believed that ceruloplasmin is involved in the catalytic formation of ferric iron by the oxidation of ferrous iron, so allowing the iron to be attached to a protein that transfers it round the body to enable its use in the biosynthesis of various ferrous compounds, especially of hemoglobin.

Copper bracelets are commonly worn by arthritis sufferers, and there is a scientific explanation for that. As previously inferred, it is believed to be possible to absorb copper through the skin and copper is known to be involved in the formation of collagen and is a commonly used treatment for arthritis and osteoporosis. Part of its effect on arthritis is likely due to the antioxidant effect of the SOD that helps to reduce the inflammation at arthritis sites.

Although a deficiency in copper can lead to serious health problems, an excess is also harmful. Potential conditions include neurological problems, liver damage and bone abnormalities, although deficiency is far more common because of the competition between copper and zinc. Zinc is a copper antagonist, as is iron and manganese, and copper imbalances can be moderated by the use of these as supplements.

The symptoms of a copper deficiency include fatigue, hair loss, stunted growth, anorexia and a host of other conditions. Luckily, however, a deficiency is rare and most people receive a sufficient amount of copper in their diet. Supplements are available to ensure an adequate intake.

There is still much to be learned about the interaction between copper and enzymes, and there is also a great deal still to be learned of its role in human metabolism and biochemistry than is currently known. However, sufficient is known already for us to be certain that copper is a very important trace element and that we should be certain that our intake is sufficient, given that zinc iron and manganese compete to prevent copper being absorbed by the body.

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Curcumin, Curcuminoids, and Curamin
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Date: April 30, 2008 10:40 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Curcumin, Curcuminoids, and Curamin

Curcumin, a potent antioxidant and anti-inflammatory, possesses many potentially far-reaching health benefits. After many studies preformed on humans, animals, and in-vitro, it has been found that curcumin may be helpful in rheumatoid arthritis, inflammatory bowel disease, pancreatitis, Alzheimer’s disease, heart disease, diabetic retinopathy, and cancer. All of these previously listed diseases share an underlying inflammation, which can be diminished by curcumin.

If you have ever eaten curry or cooked with the spice turmeric, you’ve consumed curcumin. Curcumin, which consists of several curcuminoids, is the active constituent of turmeric, which is used in curry. Turmeric is biologically related to ginger. Curcumin works as an antioxidant by boosting levels of glutathione S-transferase, which is one of the body’s main antioxidants. It also blocks the formation of the prostaglandin E2, which is compound that promotes inflammation within the body. Curcumin also inhibits the activity of nuclear factor kappa beta, which is another substance that is involved in inflammation. Additionally, it reduces the activity of COX-2 and 5-LOX, which are two more inflammation-promoting enzymes. Lastly, curcumin prevents mutations that can result in DNA, which helps to maintain healthier, younger cells.

Curcumin taken as a supplement can help with any conditions and diseases including rheumatoid arthritis, cancer, liver and kidney protection, ulcerative colitis, and other inflammatory diseases. A study using a curcumin-rich turmeric extract done at the University of Arizona Health Sciences Center in Tucson, treated rheumatoid arthritis in laboratory animals. The results showed that this extract blocked joint inflammation as well as the breakdown of joint cartilage and bone by inhibiting the genes that are involved in inflammation. Curcumin also holds a great amount of promise in preventing cancer and also as an adjunct treatment.

Animal studies have shown that curcumin can protect against colon, intestinal, oral, and skin cancers as its benefits come from several mechanisms. First of all, it blocks the cell-growth cycle in cancer cells, which leads to cell destruction. Additionally, it reduces free radicals by its antioxidant properties, which can lead to cancer-causing cell mutations. Studies have also found that curcumin can protect the liver from a variety of toxic compounds. One recent study left researchers reporting that curcumin increased the clearance of creatinine and urea, which are signs of improved kidney function. It also reduced liver damage from toxic chemicals and excess iron.

Japanese doctors have recently used curcumin to treat patients with ulcerative colitis. A combination of curcumin and conventional medications has led to the best benefits over six months of treatment. Since inflammation is the root of all chronic degenerative diseases, curcumin is likely to be beneficial for many different conditions. So far, research has identified curcumin’s benefits for diabetic retinopathy, lung disorders, and skin problems including psoriasis.

Turmeric, which is the source of curcumin, has been used as a culinary spice for the past 2,000 years, was used by ancient Greeks, and is now a widely recommended Ayurvedic medicine. It is native to India and other regions of South Asia. By eating a lot of curry, which is rich in curcumin, you may reduce the risk of Alzheimer’s disease and help to maintain mental function. One study proved that people who often ate curry had half the risk of becoming mentally impaired. By eating curry on occasion, the risk of mental decline can be reduced by a little more than a third. Curcumin can be safely taken in amounts from 500 to 8,000 mg daily. Look for a standardized supplement containing at least 90 percent curcumin.

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Gently Narrow Your "Estrogen Window" With Lignan's
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Date: January 25, 2008 12:23 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Gently Narrow Your "Estrogen Window" With Lignan's

Although many people think that breast cancer is a genetically transferred disease, the truth is that it is rarely genetically transferred, as only one in every ten cases are linked to genes for this cancer. Strong evidence points to environmental causes being the main reason for breast cancer. By avoiding synthetic chemicals that mimic estrogens, a substantial fraction of these cancers can be prevented. These synthetic chemicals are called xenoestrogens. These xenoestrogens are manmade chemicals that either imitate or enhance the effects of estrogens in the body's cells and tell these cells to grow.

During puberty, this growth message is important to a woman's body and during pregnancy and the preparation for that. At this time period, estrogens are in full force, but if estrogen stimulation is increased by chemicals, cell growth is increased even more. Uncontrolled cell growth provides the foundation for cancer. As cells rapidly multiply, which is what happens when exposed to estrogens, the chance of DNA mutation is enhanced, which causes the creation of cancerous cells. A lot of women today also deal with increased estrogen stimulation over their lifetimes due to an early onset of menstruation, late menopause, and less time spent breastfeeding. The use of estrogen-containing oral contraceptives and post-menopausal hormone replacement also add to the estrogen burden, along with obesity and being overweight.

Estrogens affect cells by binding to receptor sites. However, there are tools that help to reduce the impact of areas that have a lot of receptor sites, such as the breasts. One of the main tools is lignans, which are a group or naturally occurring plant chemicals that are found in flaxseeds. Interest in lignans began with observational studies, which found a link between high intake and reduced risk of breast and colon cancers. Studies have reinforced those results, finding that lignans inhibit the growth of breast and colon cancer and also reduce the spread of skin cancer. The real benefit of lignans starts when they reach your intestines, where friendly bacteria convert them into phytoestrogens.

Phytoestrogens are a gentler estrogen, which bind to the same receptors that other estrogens bind, but don't have the growth-accelerating effects. While they are occupying these receptors, the less kind and gentle estrogens are unable to bind to them, resulting in both an estrogenic and estrogen-blocking effect. This explains why lignans are effective both for fighting against breast cancer and reducing the effect of hot flashes other symptoms during menopause. When estrogens are low, lignans act as weak estrogens, but when they are high, lignans act as estrogen blockers.

The risk for breast cancer is strongly affected by a woman's "estrogen window", or overall estrogen exposure that has been experienced over her reproductive years. The early onset of menstruation, no pregnancies, being pregnant after age 30, limited or no breastfeeding, short menstrual cycles, and late menopause all expand the estrogen window, increasing lifetime estrogen exposure along with the risk for breast cancer. By adding lignans to the diet, women can reduce the size of the estrogen window, and therefore, block the excess estrogen stimulation in estrogen-sensitive tissues like the breasts. Additionally, lignans are also believed to reduce the risk of colon and prostate cancers. When they are delivered along with omega-3-rich flaxseed oil, they promote better cholesterol balance, heart health, joint health, better bone density, greater endurance, better blood sugar balance, and healthy skin, hair, and nails.



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Elderberry Can Boost The Immune System In The Winter
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Date: December 03, 2007 09:44 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Elderberry Can Boost The Immune System In The Winter

The immune system is frequently overworked when the days get shorter and the temperature starts to drop, and elderberry can boost the immune system in winter for those that find themselves susceptible to all the colds, flu and other viral infections that seem to come out of the woodwork at that time.

Elderberry is the fruit of the elder tree that is native to Asia, Europe and North America. They are found just about anywhere due to their tolerance for a wide range of climates and soil types, and are frequently found by river banks. There are a number of different types of elder, in both small tree and shrub form, and it is those with the black and blue berries that are useful medicinally, not those with red berries. It is not only the berries that are used, but also the elder flowers. Elderflower wine has long been a favorite country wine, and the berries are used to make jam, pies and also drunk as juice.

Elder has been used for countless years for treating viral diseases such as influenza and colds, and it has also been found by some to be effective for the treatment of cold sores (herpes simplex). Its effect on flu is thought to be that it prevents the virus from entering and infecting the body cells, but more on this later. Historically, it has been used to promote the excretion of waste products through urination and sweating, which might be another reason why it is effective against colds and flu and some general respiratory problems.

The juice contains anthocyanins in the form of anthocyanidin-3-glycosides that appear to be very bioavailable to the body. The anthocyanins are more easily absorbed than those of blackcurrant juice, and are very strong antioxidants. The antioxidant effect is reinforced by the presence of large quantities of vitamin C. This difference in bioavailability has been proved though the administration of both blackcurrant and elderberry juice to volunteers, and testing the presence of the anthocyanins in the urine. This is a measure of their bioavailability, or how easily they are absorbed by the body, and the greater this bioavailability, then the more effective is their antioxidant effect.

Separate studies have indicated that anthocyanins derived from berries in general, not just elderberry, can reduce oxidative stress due to age, and also to help brain function. An improvement in the memory of the elderly has been seen to have improved after a course of berry juices rich in these powerful antioxidants. Elderberry antioxidants also improve the stability of LDL cholesterol by protecting against free radical oxidation, and thus helping to reduce the incidence of atherosclerosis that is promoted by the deposition of the oxidized LDL cholesterol on artery walls. This in turn helps to reduce the possibility of cardiovascular disease.

However, it is its effect on the immune system for which elderberry is generally studied by the medical professions. Elderberry helps to boost the immune system predominantly through the production of cytokines. To explain how these work, a quick summary of how part of the immune system works will first be necessary.

When intrusion into the body by an antigen (foreign body) is detected, the initial response is the inflammatory response. Chemical messengers called cytokines are released into the blood to inform the other parts of the immune system that an invader has been spotted.

The immediate effect is to increase the flow of blood to the affected part of the body by dilation of the blood vessels. The spaces between the cells in the vessel walls increase to allow the larger components of the immune system, such as the phagocytes that consume and destroy bacteria. Proteins also congregate and the temperature at the site rises to promote the reactions that the body uses to eject the invaders. The tissue therefore swells due to all the extra fluid and gets hot. The area becomes painful due to the accumulation of material aggravating the nerves, and if there is an infection, pus will eventually be formed from the dead neutrophils used to kill the bacteria or virus.

There are many different types of cytokine, including those that initiate the inflammatory response and others that stop the immune response once the invader has been killed off. Other cytokines, such as the interferons, stop viruses from multiplying, and others take part in the response only to specific types of antigen. Each cytokine has a specific message to pass to the relevant components of the immune system in order that the immune response is appropriate to the invasion concerned and does not overreact. Hence, a grain of pollen in the nose will elicit a lesser response than a varicella antigen that leads to those horrible chickenpox pustules.

In general terms, cytokines give the immune system a kick start once an antigen is spotted. The elderberry anthocyanins produce predominantly inflammatory cytokines, but also one anti-inflammatory cytokine, and so helping to boost the inflammatory response.

Some viruses use what are known as spike proteins that mimic the molecules of their host in order to gain access to cells by binding to the target cell receptors. However, these spikes are easily recognized by the immune system, and the elderberry anthocyanins are active in promoting this recognition. For that reason, viruses vigorously continue to change and mutate to overcome this, one manifestation of their success in achieving this being in the annual infections of influenza that have overcome last year’s antibodies by means of this mutation.

The influenza virus contains what are known as hemagglutinin spikes on its surface which, when deactivated, cannot break through your cell walls, enter the cell and replicate, thus leading to influenza. That is the mechanism by which the constituents of elderberries help to control influenza and reduce its effect on your body. If not deactivated, the spikes allow the virus to invade the cell and provoke the immune response that you know as the flu.

Many such winter ailments have a similar mechanism, which is why, apart from its general health benefits through its high antioxidant content, that elderberry can boost the immune system in winter.



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EpiCore Benefits
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Date: April 09, 2007 05:02 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: EpiCore Benefits

Benefits

EpiCor® is a unique and novel dietary supplement used for support of immune health, with a fascinating history of discovery. In 1943, a company in Cedar Rapids, Iowa called Diamond V Mills, Inc. began manufacturing and selling a fermentation product from the yeast Saccharomyces cerevisiae, the same yeast used in bread and beer making. The product was and still is used as an additive for animal feed to help improve digestion as well as overall health in animals. It has been on the market for over 60 years.

Interestingly, when the company became self-insured, they became aware of unusually low rates of illness in employees that worked in the manufacturing plant for this animal product. This led to very low increases in their insurance premiums over the years compared to other companies, saving them quite a lot of money. Hence they began to investigate what might be the cause of the “healthfulness” of the employees at the fermentation plant. This investigation and subsequent research studies led to the formation of a new company called Embria Health Sciences, which now produces EpiCor® as a supplement for humans to support immune system health.1 Doctor’s Best® is proud to now offer the benefits of EpiCor® to its customers.

Beneficial Support of the Immune System and Activation of Natural Killer (NK) Cells in vitro*

A comparison study was performed on blood from 10 fermentation plant workers compared to that from 10 age and gender matched controls. The fermentation plant workers had several immune cell parameters that appeared superior to the control group. These included decreased levels of CD8 cells resulting in significantly increased CD4 to CD8 ratios, significantly improved cytotoxic natural killer (NK) cell activity even though total NK cells were decreased in number, higher killing efficiency of NK cells, significantly increased levels of secretory IgA, increased numbers of EpiCor™ specific antibodies, higher levels of red blood cell intracellular glutathione, and significantly lower levels of immune complexes. These results represent benefits on various cellular players of both the specific and innate parts of the immune system.1,3,4

NK cells are one of the first lines of defense used by the immune system. An in vitro study performed on human cells showed that NK cells were activated after incubation with EpiCor®, as evaluated by expression of the CD69 activation marker. The CD25 marker (IL-2 receptor) was also induced in the NK cells, although to a lesser degree.1,2 B cell activation was also noted through increased expression of CD80 and CD86 markers.2 Immediate increases in calcium levels were evident in peripheral blood mononuclear cells after exposure to EpiCor®, suggesting increased activation through calcium regulation.2

High Metabolite Immunogen*: Nutrient Make-up

Production of EpiCor® utilizes the common and harmless bakers or brewers yeast Saccharomyces cerevisiae in a patented process called MetaGen4™, a multi-stage fermentation and drying process. It differs from other yeast products in that it contains both the yeast itself as well as the metabolites or “nutrilites” formed by the fermentation process, which are present in the media.1 Together the media containing the metabolites and the yeast are dried to form EpiCor®. Analysis of EpiCor® reveals that it contains a mixture of natural polyphenols, phytosterols, beta-glucans, mannan oligosaccharides, fiber, trace amounts of B vitamins and minerals, as well as a host of other nutritional compounds.1,2

Beneficial Antioxidant Activity*

EpiCor® was tested for antioxidant activity in an in vitro assay called the Oxygen Radical Absorbance Capacity assay (ORAC). In this assay, EpiCor® was shown to have a total ORAC antioxidant level of 610 micromol TE (tocopherol (vitamin E) equivalents) units (ORAC units) per gram dry weight, which soared above other high antioxidant level foods such as cranberries (93 ORAC units per gram dry weight) and blueberries (62 ORAC units per gram dry weight).1,3,5

In another study, freshly isolated human neutrophils were treated with EpiCor® followed by the free radical generator hydrogen peroxide. Cells were treated with a dye that fluoresces when attacked by free radicals. Those cells treated with EpiCor® showed decreased fluorescence intensity compared to control cells not treated with EpiCor®, verifying antioxidant activity in vitro.2

Safety

Numerous safety tests have been conducted on EpiCor®, revealing an extremely safe profile. Animal studies performed by a leading toxicology laboratory showed no indication of any toxic effects of EpiCor®. An acute oral toxicity study on 20 rats showed that the product was safe when given to rats at a single oral dose of 2000 milligrams per kilogram of body weight (equivalent to a human ingesting 280 capsules at once). After 2 weeks the rats showed no clinical symptoms, no deaths, no abnormalities in body weight, and no gross pathological changes. The same safety results were found in a subchronic toxicity study where rats were given up to 1500 milligrams daily for 90 days (equivalent to a human ingesting up to 210 capsules daily for 1.5 years). Again, absolutely no signs or symptoms of toxicity were noted in these animals.1,3

In addition, a standard bacterial reverse mutagenicity test (AMES test) as well as a mammalian cell mutation assay using mouse lymphoma cells revealed no evidence of any increase in mutation rates after exposure to EpiCor®. EpiCor® also showed no evidence of mitogenicity (inducing increased cell division) in a human lymphocyte proliferation assay. This suggests that EpiCor® does not cause over-reactivity of cells1,3.

The effect of EpiCor® on specific liver enzymes CYP1A2 and CYP3A4 (enzymes involved in metabolizing certain drugs and other compounds) was assessed. Immortalized hepatocytes (liver cells) were treated with various concentrations of EpiCor® and compared to both positive and negative controls. EpiCor® did not increase the expression or activity of the liver enzymes, suggesting that it may not affect the metabolism of other substances or medications metabolized by these enzymes if they are taken simultaneously. It also did not appear to be toxic to the cells as measured by lactate dehydrogenase assays and microscopic analysis.1

Lastly, EpiCor® was tested for safety in humans in an open label study on 15 adult men and women given a single 500 milligram dose for 30 days. On various days throughout the study vital signs were monitored, and blood and urine samples were analyzed. No clinically relevant abnormal effects on the participants were found1.

 

EpiCor® also currently has received self-affirmed Generally Regarded as Safe (GRAS) status by an expert panel that included eminent toxicologists1.

 

EpiCor® is a novel compound with an incredibly unique composition that has been shown to enhance immune system function.*

Suggested Adult Use: Take one capsule daily with or without food.

 

 

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

Scientific References

1. Embria Health Sciences

2. Hart et al. A new Saccharomyces cerevisiae based product has anti-inflammatory effects while specifically activating human NK and B lymphocyte subsets. Unpublished study, personal communication.

3. Schauss AG, Jensen G, Vojdani A, Financsek I. After decades of ingestion by farm animals, the discovery of a yeast fermentate with unexpected significant immune modulatory activity when consumed by humans. [abstract] Journal of the American College of Nutrition, 2006; 25(5): 465.

4. Schauss AG, Vodjani A. Discovery of an edible fermentation product with unusual immune enhancing properties in humans. [abstract] FASEB J, 2006; 20(4):A143.

5. Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem 2004 Jun 16;52(12):4026-3



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At Last some good news concerning breast health!
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Date: February 23, 2006 03:33 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: At Last some good news concerning breast health!

At last, some good news concerning breast health!

Brevail is for women interested in maintaining optimal breast health.

Perhaps you, like many woman, are concerned with the important issue of breast health. Annual mammograms, monthly self breast exams, escalating national statistics, or perhaps an unfortunate occurence in a loved one has raised awareness and concern in many of us.

There is now reason for Optimism

Brevail is the first all-natural product to address the maintenance of orderly cellular division in the preservation of healthy breast tissue.

Research suggests that our bodies use natural plant lignans, now sparse in the modern diet, to sarely and gently buffer and balance potentially adverse effects of excess or toxic estrogens, established as the most well-known cause of certain breast problems.

Estrogen left unchecked may result in rapid multiplication of breast cells, as well as inability for cells to repair potential mutations between cellular divisions.

Body and Nature is balance

Brevail was university researched and developed to increase lignan concentrations in the body to levels found in women who collectively demonstrate an extraordinary history of breast health.

After only 48 hours of Brevail supplementation, women participating in a university based, oral pharmacokinetics study achieved lignan concentrations in plasma and urine equivalent to a reference group of women with a well-established history of extraordinary breast health.

The results is a gentle return to balance between body and nature, just as nature intended.

Hormonal Harmony

In addition to the primary purpose of optimal breast health, many women have reported secondary benefits of brevail related to hormonal balance including improvements in pre and peri-menopausal, menopausal and post-menopausal discomforts. Further, many women have reported a greater sense of well-being associated to a reduction of stress and apprehension, and for taking a positive step toward a healthy future.

Brevail has good news for you, a “window” of opportunity.

The good news is a revolutionary new approach to breast health. Though a new approach, managing your “Estrogen window” is time honored, true, and scientifically established.

Your lifetime exposure to estrogen is the most well-known risk factor for breast related health challenges. Your cumulative lifetime exposure to estrogens is referred to as your “Estrogen window.” Influences that increase and extend exposure to estrogen are said to “open” the window. Those that reduce or shorten exposure are said to “Close “ it. The wider and longer the window is left open, the greater your risk for breast related complications.

Managing your estrogen window empowers you to choose a healthy future.

Brevail is the first all-natural product designed to address the estrogen window by gently displacing excess or toxic estrogens. Adequate rest, exercise, a plant-based diet, and avoidance of alcohol are also ways to which you can consciously choose to manage your estrogen window toward a healthy future.

Make a decision for health, life, and vitality!

Proactive Breast Health is a monumental shift in thinking and action, away for passive resignation and toward proactive empowerment. The difference between fate and destiny is that you can plan your destiny in advance. Make a commintment to Brevail, and make a commitment to health, life, and vitality today.

Brevail Philanthropy

Brevail donates a percentage of all proceeds to the Breast Cancer Prevention Foundation, established to fund scientific and clinical research into breast cancer prevention, as well as to educate the public and medical community on proactive and preventative breast health measures, and for the purpose of outreach and support for women with breast cancer.

Brevail, winner of two consecutive research grants

Brevail was awarded an unprecedented two consecutive research grants from the Washington Technology Center, University of Washington, in the course of the 6-year span in which it was developed. Lignan Based strategies for Cancer Prevention was the topic and title of the grants.



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GliSODin Anti-Aging and Antioxidant Protection
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Date: December 19, 2005 08:47 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: GliSODin Anti-Aging and Antioxidant Protection

GliSODin Anti-Aging and Antioxidant Protection

  • Superior Anti-Aging Formula
  • Stimulates Natural Antioxidant Defenses
  • Helps Protect DNA
  • Reduces Oxidative Stress
  • Prevents Oxygen Related Cell Damage

In the time it takes you to finish reading this article, you, your body and your cells will have aged. Some, more than others. Nevertheless, every second that ticks away should serve as a reminder that our time here is temporary. How much time we actually end up with depends on many things. Diet. Lifestyle. Environment. Superoxide Dismutase? I’ll explain. What some of the healthiest individuals fail to realize is that our bodies age from the inside out. Aging is not the result of passing time, but rather the result of what we’re exposed to environmentally, physically and chemically. It is the integrity of our cells, not our clocks, that determine how smooth the aging process fares.

Each day, we’re subjected to millions of elements that affect us in ways seldom seen, felt or noticed. From the moment we’re born, we rely on our cells to work around the clock - producing energy, fighting infections and sustaining life. These same cells eventually determine the rate at which we show (or hide) our age.

Taking into consideration that our planet has no shortage of toxins & germs, the need to safeguard our cells becomes very real. Constant exposure to exhaust, secondhand smoke, heavy metals, lead, fluoride and uncountable other noxious compounds should ideally provide us with nothing more than a routine immune system workout. Unfortunately, over long periods they hinder our “resistance” abilities and become stepping stones to accelerated aging.

Antioxidants. We’ve all heard the term before, and may even have a general understanding of their role. But to better grasp just how vital they are, it helps to know what’s happening at the cellular level. Free radicals are unstable molecular thieves that often lack electrons. To compensate, they rob healthy cells - a process better known as oxidation. Antioxidants work with the immune system to prevent oxidation, and clean up the mess it leaves behind. Hence, the name.

There are two types. Exogenous antioxidants are derived from our diet and include vitamins A, E, and C along with others such as alpha lipoic acid, selenium, CoQ10, grape seed, pycnogenol and zinc. To date, we’ve been limited to exogenous antioxidants as a way to increase the rate at which our body wards off oxidation. They are not, however, our first line of defense. At birth, each and every one of us is equipped with three primary endogenous enzymatic antioxidants; SOD (Superoxide Dismutase), Glutathione Peroxidase (GPx) and Catalase.

While both types of antioxidants are beneficial, we’ve become reliant on those from the diet to compensate for our inability to boost the effectiveness of our 3 primary antioxidants. For years, researchers have been examining ways to enhance the activity of our built-in bodyguards. One in particular, Superoxide Dismutase (SOD) has been of foremost interest. SOD targets what many researchers regard as one of our greatest health threats and aging accelerators - Superoxide radicals. These highly reactive, merciless molecules incite enormous amounts of oxidative stress and are capable of wreaking havoc on healthy cells. When cells are left unprotected by SOD, the results can be disastrous - respiratory problems, premature aging, memory loss, cardiovascular challenges, vision failure and joint structure damage, among others.

Until now, we’ve been at the mercy of our natural SOD reserves to fight superoxides. Researchers have been working feverishly to produce an effective oral SOD supplement, but have continually encountered a frustrating hurdle - exposure to gastric acid denatures SOD, rendering it useless. As a result, the only effective way to supplement SOD was through injections. These, however, only yielded short-term spikes. And then something remarkable happened that changed everything. Nutrition scientists in France determined that by combining Cucumus melo (a melon high in SOD) with a wheat gliadin stabilizer, it would be possible to prevent SOD from deteriorating in the digestive tract, while preserving it in the blood for extended periods. Not only is this the answer to a puzzle that has plagued researchers, it’s a breakthrough that will impact the life of anyone seeking longevity and vitality.

As the first proven oral SOD supplement ever introduced to the public, GliSODin® has taken antioxidant protection, immune support and antiaging science to an entirely new level. The primary function of GliSODin® is to scour the body for superoxide radicals and reduce them to less reactive ions that can be swept away; a process known as dismutation. In addition, GliSODin® reduces the oxidation vulnerability of healthy cells, protects mitochondrial activity and safeguards DNA structure.

What’s most remarkable is that GliSODin® has actually been shown to stimulate the body’s own natural production of all three enzymatic antioxidants, including SOD. For the first time in history, we will have the ability to enhance the effectiveness of our body’s primary defense mechanism.

New GliSODin® from NOW® represents the ultimate in antioxidant protection. By increasing one’s level of SOD while stimulating the natural production of Glutathione Peroxidase and Catalase, GliSODin® delivers antioxidant protection unlike any previously released dietary supplement. Remember, the aging process begins at a level that we simply can not see, the cellular level. Shielding your cells from superoxide damage is one of the smartest steps you can take against aging before your due time. GliSODin® has made this a reality.



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The Free Radical Theory
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Date: December 14, 2005 12:11 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: The Free Radical Theory

The popular theory has been the subject of a great deal of research. Developed by Denham Harman, M.D., Ph.D., at the University of Nebraska in 1956, the free radical theory proposes that unstable molecules known as free radicals are responsible for inflicting extensive cellular damage, which causes cell death and dysfunction and eventually, disease. The most common type of free radicals are oxygen derived, and free radical damage is often referred to as oxidation.

Environmental sources of free radicals include radiation (I.E., sun exposure, X-rays), ozone and nitrous oxide, heavy metals (i.e., mercury, cadmium, lead), smoke, alcohol, saturated fat, and other chemicals and pollutants. The body itself generates free radicals in performing essential bodily functions including energy production and immune activities. Fortunately, the body also has the ability to create antioxidants to neutralize the free radicals and prevent extensive cellular damage. When free radicals are not neutralized by antioxidants, they inflict large-scale cellular damage which can cascade and lead to age-related degenerative diseases such as osteoarthritis, osteoporosis and age –relaged macular degeneration. For example, free radical damage to joint cells may cause the cartilage to become rough or break down, and can lead to the development of osteoarthritis. Antioxidants are needed to comb at free radicals and prevent this cellular damage. “Oxidative stress can lead to DNA mutations, cell death, and disease, all of which contribute to aging,” said Gerald R. Cysewski, president and chief executive officer (CEO) at Cyanotech corp. “Antioxidants are produced naturally by the body to combat oxidative stress by neutralizing free radicals. Increasing the amount of antioxidants in one’s system by consumption of supplements can provide further protection from the damaging effects of free radicals.”

Because the body is continually assaulted by free radicals, antioxidant supplementation is often necessary. “by taking certain nutrients that our bodies stop producing over time, supplements help us to maintain a youthful look and health, which in turn enhances the quality of life,” Alkayali said. “Furthermore, supplements can help decrease oxidative stress that may otherwise accompany age-related illness and disease.”

Many Substances are known antioxidants including certain enzymes, vitamins, phytochemicals and minerals, and include Vitamin C, Vitamin E, alpha-lipoic acid, coenzyme Q10 (CoQ10), Carotenoids, Selenium, superoxide dismutase, melatonin, quercetin, catechins, and zinc.

Consuming a diet high in plant sources of powerful antioxidants is an important step to deter ageing, because nutrients from foods are often highly bioavailable and can act synergistically to increase their health benefits. Garlic contains several antioxidant phytochemicals and minerals including allicin, beta-carotene, quercetin, selenium and zinc, and may have a protective effect against stomach and colorectal cancers.

Catechins are potent antioxidants flavonoids, with the best known source being green tea; they include gallocatechin (GC), epigallocatechin (EGC), epicatechin (EC) and epigallocatechin gallate (EGCG). These antioxidants are being studied for their powerful abilities to combat free radical damage. In particular, EGCG has been researched for its reported protection against certain cancers and Alzheimer’s disease.

Green Foods such as seaweed, sea vegetables, young grain grasses and shoots, broccoli, cabbage and other green leafy vegetables pack a nutritional punch due to their concentratged amounts of antioxidant carotenoids, vitamins and the enzyme superoxide dismutase (SOD). SOD is produced by the body and neutralizes free radicals known as superoxide radicals, which cause damaging fat oxidation. GliSODin is a patented form of SOD derived from cantaloupe and bound to a wheat protein for superior bioavailability. “GliSODin promotes the body’s production of its own endogenous antioxidants, including SOD, catalase and glutathione peroxidase, in virtually every cell,” said Eric Anderson, brand manager at P.L. Thomas. “This activation of the cellular antioxidant defenses across the whole body creates a state of alertness against any shock of oxidative stress, including sun rays, to which our body may be exposed.”

Pomegranates contain two powerful antioxidants—ellagic acid, derived from fruit’s seeds, and punicaligans, found in the juice. “Research has shown that the juice from the pomegranate, rich in polyphenols, reduces oxidative stress by helping to produce enzymes to fight free radicals,” Alkayali said. NeoCell Corp. manufactures of ellagic-acid based Pomegranate Power, while P.L. Thomas supplies POM40p, a kosher-free pomegranate juice extract standardized to 40-precent punicocides, polyphenols belong to the punicalagin family.

Consumer demand is on the rise for products that address degenerative health conditions, including supplements that support function of the bones, joints, eyes. According to a June 2005 report by the freedonia group, “Bone and joint care products will continue to dominate the health maintenance segment, spurred by a growing customer base and a plethora of new and improved products expected to soon enter the marketplace.” The report also projected rapid gains for vision care. “Demand for vision care products will be propelled by aging baby boomers who are becoming aware of debilitating eye conditions and seeking both preventive measures and ameliorative treatments.” Dietary Supplements can help prevent and ease symptoms of age-related diseases affecting the joints, bones and eyes, including osteoarthritis, osteoporosis and age-related macular degeneration (AMD).



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New Test for Early Cancer Detection
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Date: October 18, 2005 10:17 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: New Test for Early Cancer Detection

A new test for early cancer detection

Researchers out of Johns Hopkins University believe they may have found a new method of testing for cancerous growths that allows for much earlier detection. The new method of testing saliva and urine does not work for all cancers but would allow doctors to check for DNA abnormalities in these fluids. If these tests prove viable, they would allow for cancer detection years before symptoms appear.

Tests on patients suffering from cancers of the lung, voice box, mouth, throat and bladder showed 100 percent sensitivity to abnormal DNA particles. Researchers say that a mutation in the tumor guaranteed a detection in the bodily fluid.

The test works by detecting DNA strands that have been dumped by the tumor into the bloodstream and excreted by the body. These mutated DNA strands lead to dysfunctional cell division and give rise to tumor development and growth. In order to further test their theory, researchers tested a urine sample of the late U.S. Vice President Hubert Humphrey taken nine years before he was diagnosed with urinary cancer. The test showed the presence of DNA mutations.

Researchers are optimistic that these studies can push cancer detection up two, four or more years from its current position. New tests are being developed that search for more numerous DNA strands and are 200 times more sensitive than the original test. Major clinical research for these tests will begin next year.



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Curcumin - Turmeric Extract
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Date: August 19, 2005 12:47 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Curcumin - Turmeric Extract

Curcumin

Turmeric- History and Traditional Usage

Native to Southeast Asia, Curcuma longa is a tall
tropical shrub with large oblong leaves and pale yellow flowers.
The genus “Curcuma” belongs to the Zingiberaceae family, which
includes ginger.1 The plant possesses a large root structure
with fleshy, bulbous underground parts called “rhizomes.” These
rhizomes, known as turmeric root, are harvested at maturity,
dried and cured for commercial use. Chemical analysis shows that
dried turmeric contains essential and volatile oils, with a
curcuminoid content of 2.5 to 5.0 %.2

In addition to its
popularity as a spice, turmeric is used as a dye for cloth and
coloring agent in foods and cosmetics, thanks to its rich yellow
color. Turmeric also serves as a preservative, probably owing to
the antioxidant and antimicrobial properties of curcumin.
Extracts of Curcuma longa have demonstrated in vitro
antibacterial and anti-fungal effects.3

Turmeric is named in
ancient Ayurvedic and Chinese herbal texts as a traditional folk
remedy. Historically, turmeric was used externally for wounds,
and sprains, and internally for digestive complaints,
rheumatism, liver disorders, coughs and colds.4
Benefits

Protects cells and tissues by fighting free radicals.*

Supports joint function*

The numerous beneficial
effects attributed to turmeric stem in large measure from the
antioxidant properties of curcumin. Antioxidants neutralize free
radicals, which are highly unstable molecules that can damage
cellular structures through abnormal oxidative reactions.
Curcumin is a potent “scavenger” of the superoxide radical, a
free radical that initiates potentially harmful oxidative
processes such as lipid peroxidation.5 Through this activity,
curcumin has been shown to protect skin cells from the injurious
effect of nitroblue tetrazolium, a toxin that generates
superoxide radicals. Curcumin also increases survival of cells
exposed in vitro to the enzyme hypoxanthine/xanthine oxidase,
which stimulates superoxide and hydrogen peroxide production.
Curcumin itself is not toxic to cells, even at high
concentrations. Pure curcumin was shown to be less protective
than a mixture of curcuminoids, indicating a possible synergism
among curcuminoids.6 Because free radicals are involved in aging
and exert harmful effects on skin, these results suggest
curcumin may help slow skin aging.

Curcumin demonstrates
several other in vitro effects linked to free radical
scavenging. Curcumin scavenges nitric oxide, a compound
associated with the body’s inflammatory response.7 Pure curcumin
and turmeric extracts protect red blood cells from lipid
peroxidation induced by hydrogen peroxide.8 Curcumin has been
shown to protect DNA from oxidative damage, inhibit binding of
toxic metabolites to DNA, and reduce DNA mutations in the Ames’
test.9 Although additional studies suggest an anticarcinogenic
effect of curcumin, through protection of DNA,10 one in vitro
study found that curcumin induced DNA damage in human gastric
mucosal cells.11 It is speculated that curcumin may act as a
pro-oxidant in the presence of transition metal ions such as
copper and iron. (This is true for other antioxidants, including
vitamin C.) Curcumin also demonstrates in vitro inhibition of
COX-I and COX-II enzymes, which are involved in the inflammatory
reaction.12 Together these results strongly suggest that
curcumin is a potent bioprotectant with a potentially wide range
of therapeutic applications.

Animal studies- In vivo protective effects

Through its free radical scavenging
properties, curcumin has shown bioprotective effects in animals.
In one study, rats were treated with isoproterenol, a chemical
that causes cardiac hypertrophy (enlargement of the heart) due
to abnormal collagen metabolism. Co-treatment with curcumin
reversed the degradation of collagen and cardiac hypertrophy
induced by isoproterenol.13 Curcumin protects mice from
detrimental effects of radiation, by stabilizing the glyoxalase
system, a biological system that regulates cell division.14
Curcumin protects livers of rats from the damaging effects of
carbon tetrachloride (CCl4), a potent hepatoxin that injures the
liver via its free radical metabolite, CCl3.15,16 Curcumin
protected rats from alcohol-induced brain damage, in a study in
which oral administration of curcumin reversed lipid
peroxidation, reduced levels of free-radical metabolites and
increased levels of glutathione, a major physiologic
antioxidant.17 Curcuma longa extracts have shown
anti-inflammatory effects in rats.18

Human Trials

Curcumin exhibits free-radical scavenging ability when
administered to humans. In an open trial (uncontrolled), 18
healthy individuals ranging in age from 27 to 67 years consumed
a Curcuma longa extract, at a dose supplying 20 mg curcuminoids,
for 45 days. Before and after blood tests showed a statistically
significant decrease in lipid peroxides.19 Preliminary trials
have tested the anti-inflammatory action of curcumin, with
results that verify the traditional use of turmeric as an
anti-rheumatic herb. In a short-term double-blind, cross-over,
comparative study, 18 people received curcumin (1200 mg daily)
or phenylbutazone for two week periods. Both curcumin and
phenylbutazone produced measurable improvements in joint
flexibility and walking time. The subjects reported results only
with phenylbutazone, which may be explained by the short
duration of the trial.20 In a small placebo-controlled trial
comparing curcumin to phenylbutazone, 45 patients with
post-operative inflammation received curcumin, phenylbutazone or
placebo. The anti-inflammatory effects of curcumin and
phenylbutazone were comparable and superior to placebo.21
Curcumin has not been found to produce an analgesic (pain
relieving) effect.

Bioperine-Nature’s Absorption Enhancer
Boosts Curcumin Absorption*

Traditional Ayurvedic herbal
formulas often include black pepper and long pepper as
synergistic herbs. The active ingredient in both black pepper
and long pepper is the alkaloid, piperine. Experiments carried
out to evaluate the scientific basis for the use of peppers have
shown that piperine significantly enhances bioavailability when
consumed with other substances.22 Several double-blind clinical
studies have confirmed that Bioperine® increases absorption of
nutrients.23

Curcumin is poorly absorbed in the intestinal
tract, limiting its therapeutic effectiveness. Oral doses are
largely excreted in feces, and only trace amounts appear in the
blood. Concomitant administration of 20 mg of piperine with 2
grams of curcumin increases the bioavailability of curcumin by
2000%.24

Scientific References


1. Majeed, M., Badmaev,
V., Shivakumar, U., Rajendran, R. Curcuminoids. 1995.
Piscataway, NJ: NutriScience Publishers.
2. Srimal, R.C.
Turmeric: a brief review of its medicinal properties.
Fitoterapia 1997;68(6):483-93.
3. Ammon, H.P.T., Wahl, M.A.
Pharmacology of Curcuma longa. Planta Medica 1991;57:1-7.
4.
Snow, J.M. Herbal Monograph: Curcuma longa L. (Zingiberaceae).
The Protocol Journal of Botanical Medicine, Autumn
1995:43-46.
5. Rao, N.S., Rao, M.N.A. Free radical scavenging
activity of curcuminoids. Arzneim.-Forsch./Drug Res.
1996;46(2):169-171.
6. Bonté. F. et al. Protective effect of
curcuminoids on epidermal skin cells under free oxygen radical
stress. Planta Medica 1997;63:265-66.
7. Rao, S., Rao, M.N.A.
Nitric oxide scavenging by curcuminoids. J Pharm. Pharmacol.
1997;49:105-7.
8. Lalitha, S., Selvam, R. Prevention of
H2Os-induced red blood cell lipid peroxidation by aqueous
extracted turmeric. Asia Pacific J Clin Nutr
1999;8(2):113-14.
9. Deshpande, S.S., Maru, G.B. Effects of
curcumin on the formation of benzo[a]pyrene derived DNA adducts
in vitro. Cancer Letters 1995;96:71-80.
10. Subramanian, M., et
al. Diminution of singlet oxygen-induced DNA damage by curcumin
and related antioxidants. Mutation Research
1994;311:249-55.
11. Blasiak, J., Trzeciak, A., Kowalik, J.
Curcumin damages DNA in human gastric mucosa cells and
lymphocytes. Journal of Environmental Pathology, Toxicology and
Oncology 1999;18(4):271-76.
12. Ramsewak, R.S., DeWitt, D.L.,
Nair, M.G. Cytotoxicity, antioxidant, and anti-inflammatory
activities of Curcumins I-III from Curcuma longa. Phytomedicine
2000;7(4):303-308.
13. Nirmala, C. Anand, S., Puvanakrishnan,
R. Curcumin treatment modulates collagen metabolism in
isoproterenol induced myocardial necrosis in rats. Molecular and
Cellular Biochemistry 1999;197:31-37.
14. Choudhary, D.,
Chandra, D. Kale, R.K. Modulation of radioresponse of glyoxalase
system by curcumin. Journal of Ethnopharmacology
1999;64:1-7.
15. Park, E-J. et al. Protective effect of
curcumin in rat liver injury induced by carbon tetrachloride. J
Pharm. Pharmacol. 2000;52:437-40.
16. Deshpande, U.R. et al.
Protective effect of turmeric (Curcuma longa L.) extract on
carbon tetrachloride-induced liver damage in rats. Indian
Journal of Experimental Biology 1998;36:573-77.
17.
Rajakrishnan, V. et al. Neuroprotective role of curcumin from
Curcuma longa on ethanol-induced brain damage. Phytotherapy
Research 1999;13:571-74.
18. Arora, R.B. Basu, N., Kapoor, V.,
Jain, A.P. Anti-inflammatory studies on Curcuma longa
(Turmeric). Indian J Med Res 1971;59(8):1289-95.
19.
Ramirez-Bosca, A. et al. Antioxidant curcuma extracts decrease
the blood peroxide levels of human subjects. Age
1995;18:167-69.
20. Deodhar, S.D., Sethi, R. Srimal. R.C.
Preliminary study on antirheumatic activity of curcumin
(diferoyl methane). Indian J Med Res 1980;71:632-34.
21.
Satoskar, R.R., Shah, S J. Shenoy, S.G. Evaluation of
anti-inflammatory property of curcumin (diferoyl methane) in
patients with postoperative inflammation. International Journal
of Clinical Pharmacology, Therapy and Toxicolgy
1986;24(12):651-54.
22. Atal, C., Zutshi, U., Rao, P.
Scientific evidence on the role of Ayurvedic herbals on
bioavailability of drugs. Journal of Ethnopharmacology
1981;4:229-232.
23. Bioperine®–Nature's Bioavailability
Enhancing Thermonutrient. Executive Summary. 1996; Sabinsa
Corporation, Piscataway, N.J.
24. Shoba, G., et al. Influence
of piperine on the pharmacokinetics of curcumin in animals and
human volunteers. Planta Medica 1998;64(4):353-6.

© 2002
Doctor's Best, Inc. Revised 8/13/02

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



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SAFETY
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Date: July 15, 2005 12:54 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: SAFETY

SAFETY

The FDA has not given stevia the “generally recognized as safe” label; however, the herbal compound has been used for hundreds of years without any recorded side effects. Japanese studies found that the sweetener consistently yielded a nontoxic status, even after extensive toxicity trials. The Japanese have used stevia for years with the approval of Japanese control agencies, and in Paraguay the herb has enjoyed hundreds of years of consumption with no reports of detrimental side effects. No anomalies have ever been observed in cell, enzyme, chromosomal or other significant physiological parameters during these toxicity tests. Stevia has not been associated with any form of cancer or birth defects. Stevia consumption in Japan was approximated at 170 metric tons in 1987 with no cases of documented side effects (Bonvie, 38).

Scientific Toxicology Studies

Comprehensive and tedious clinical studies in Japan have more than established the fact that stevia can be taken safely. One such study used over 450 rats who were fed stevia for up to two years with doses many times greater than human consumption.

No changes were observed in organ weights, blood biochemistry, growth, appearance, or cellular function (Bonvie, 38). The Japanese have found no indication that stevia affects fertility or unborn children and have never linked it to cancer or other cellular mutations. (NOTE: Diabetics and people with other medical conditions should always consult their physician before using this or any other dietary supplement and should never alter or stop their medication unless advised to by their physician.)

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SUMMARY OF SPECIFIC ACTIONS ASSOCIATED WITH PYCNOGENOL
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Date: July 13, 2005 12:39 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: SUMMARY OF SPECIFIC ACTIONS ASSOCIATED WITH PYCNOGENOL

SUMMARY OF SPECIFIC ACTIONS ASSOCIATED WITH PYCNOGENOL

  • • It strengthens skin and promotes elasticity, which means it fights wrinkles and can soften facial lines.
  • • It protects capillaries from free radical damage, which helps to prevent phlebitis, varicose veins and bruising. Consequently, it has been recommened for anyone with history of blood clots.
  • • For joint pain and injuries, pycnogenol acts as a natural anti-inflammatory without the negative side effects of overthe- counter or prescription drugs. It also helps to alleviate the pain associated with arthritis and other joint conditions. It has been recommended as a daily supplement for anyone who engages in continuous physical activity.
  • • It helps to control and prevent water retention or edema in the tissues by decreasing fluid leadage from the cells, which results in swelling. Anyone suffering from swollen ankles or fingers should look into its diuretic properties.
  • • P ycnogenol is an excellent supplement for any type of allergy, especially hay fe ver because it decreases the production of histamines which are responsible for all the miseries of allergy symptoms.
  • • It can reduce the risk of diabetic retinopathy and in some cases has decreased blood sugar levels. Diabetes and its complications seem especially responsive to the flavonoid compounds contained in pycnogenol.
  • • Because it crosses the blood-brain barrier, it may be helpful in cases of Alzheimer’s disease, Parkinson’s disease and Senile Dementia.
  • • Pycnogenol may guard against the formation of tumors or other cell mutations caused by free radicals and may help protect against degenerative diseases like cancer.
  • • Atherosclerosis and other circulatory diseases including strokes, can benefit from the vessel strengthening action of pycnogenol.
  • • Prostate problems seem especially responsive to certain doses of pycnogenol.

    A REMARKABLE PREDICTION

    The general consensus among many experts in the health field is that Pycnogenol is destined to become the most vital of all antioxidant compounds. As more scientific evidence presents itself, Pycnogenol may eventually sweep 21st century dietary supplementation.

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    PYCNOGENOL - ITS REMARKABLE BENEFITS
    TopPreviousNext

    Date: July 13, 2005 12:26 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: PYCNOGENOL - ITS REMARKABLE BENEFITS

    PYCNOGENOL - ITS REMARKABLE BENEFITS

    New to North America but not to Europe, this natural product is considered safe and effective in the treatment of various diseases and for the maintenance of optimal health. This family of bioflavonoids is non-toxic, water soluble and highly bioavailable. Because proanthocyanidins scavenge free radicals so effectively, they have shown remarkable curative effects. Extensive research demonst rates that proanthocyanidins are such potent antioxidants, they find and neutralize free radicals with great rapidity, allowing cells to regenerate rather than deteriorate. Specific actions associated with Pycnogenol include:

  • • Binds with Collagen Fibers and helps restore skin elasticity
  • • Helps prevent excess wrinkling
  • • Protects capillaries from free radical damage which helps prevent phlebitis, varicose veins and bruising
  • • Treats Joint Pain and Injuries as a natural antiinflammatory
  • • Helps control and prevent edema
  • • Decreases the production of histamines in allergic reactions such as Hay Fever
  • • Reduces the risk of and treats diabetic retinopathy

    PYCNOGENOL SPECIFICALLY TARGETS: SKIN AND ELASTICITY

    Testing has suggested that Pycnogenol flavonoids exhibited an anti-enzyme effect which prevented the break down of collagen and elastin, the very compounds which keep skin firm and inhibit the formation of wrinkles.7

    TUMOR RELATED DISEASES

    Unquestionably, studies have shown that Pycnogenol has the ability to inhibit cellular mutations.8 The implications of this finding for anyone suffering from tumor related disease which originates from cellular malfunctions should not be underestimated.

    CARDIOVASCULAR CONDITIONS

    The potential of Pycnogenol to pr e vent cellular deterioration or uncontrolled growth is profound to say the least. Several investigations have shown that if it is taken on a daily basis, Pycnogenol benefits people suffering from cardiovascular diseases and breast tumors.9 In addition, double blind placebo controlled studies have indicated that patients suffering from circulatory insufficiencies and diseases of the lymph system showed significant improvement in pain control and vessel elasticity after taking these flavonoids.10

    VISION

    Subsequent experiments concluded that the family of bioflavonoids contained in Pycnogenol is capable of improving night vision and initialing “a rapid and marked improvement of visual performances after glare in comparison with control group.”11

    WATER RETENTION AND EDEMA

    Pycnogenol is particularly valuable for anyone who suffers from water retention and edema. Studies at the Institute of Physiology at the Bulgarian Academy of Sciences confirm that this biofl avonoid compound stabilized capillary walls, which decreased fluid leakage into tissues which causes swelling and pressure.12

    WHAT PATHOLOGICAL CONDITIONS RESPOND TO PYCNOGENOL?

    The bioflavonoids found in Pycnogenol have been clinically indicated in the following pathological conditions:

  • • circulatory diseases, including cardiovascular disease and stroke
  • • varicose veins
  • • edema
  • • bruising
  • • capillary fragility (commonly seen in diabetes can cause retina damage and decrease sight)
  • • visual disturbances
  • • aging of skin
  • • diabetes
  • • stroke
  • • prostate disease
  • • wrinkles
  • • stress

    PYCNOGENOL HAS THERAPEUTIC VALUE FOR THE FOLLOWING CONDITIONS:

  • • BELL’S PALSY
  • • ULCERS
  • • EYESIGHT: INCREASES VISUAL ACUITY
  • • CANCERS: INHIBITS TUMOR GROWTH
  • • HEART DISEASE
  • • ATHEROSCLEROSIS
  • • MULTIPLE SCLEROSIS
  • • COLDS AND FLU
  • • PROSTRATE PROBLEMS
  • • LUPUS
  • • ARTHRITIS
  • • MEMORY/ALZHEIMER’S DISEASE, SENILE DEMENTIA
  • • STROKE
  • • PARKINSON’S DISEASE
  • • PSORIASIS
  • • BURSITIS
  • • GASTROINTESTINAL PROBLEMS
  • • INSOMNIA
  • • IT CAN ALSO HELP TO INCREASE LONGEVITY AND OVERALL HEALTH

    PYCNOGENOL CAN CROSS THE BLOOD-BRAIN BARRIER

    One of the most significant advantages of this flavonoid compound is its ability to cross the blood-brain barrier. Consequently, it acts as an invaluable therapeutic agent in treating depression, chronic fatigue, insomnia or loss of memory.

    ANTI-ULCER FORMING PROPERTIES

    Other scientific tests have indicated that proanthocyanidins also posses anti-ulcer properties and may work to prevent the formation of undesirable chemicals in the stomach.13

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    HERBAL FIRST AID KIT
    TopPreviousNext

    Date: July 11, 2005 09:44 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: HERBAL FIRST AID KIT

    HERBAL FIRST AID KIT

    It is important to know the area where you will be going to determine plants that will be available in case they are needed and access to emergency help if necessary. The herbal first aid kit is meant to be used for minor conditions that may occur while traveling. Any serious condition should be seen by a health care professional. Gathering herbs along the trail can be fun as well as useful. Simple plant remedies can be brought along in the first aid kit. Major injuries require immediate medical attention by a professional. Minor problems can often be taken care of with simple herbal remedies. Supplies can be obtained from the local health food store or by collecting plants locally.

    Along with the herbs, a few supplies should be part of the kit available at the local drugstore or market.


    1. scissors
    2. thermometer
    3. band aids of all sizes
    4. gauze
    5. tweezers
    6. blister kit
    7. needle
    8. moleskin for blisters
    9. adhesive tape
    10. first aid instruction manual
    11. herbal first aid manual

    ALOE VERA: Aloe is great for minor skin abrasions, burns and as a natural laxative. It is excellent to soothe and repair damage from a sunburn. Aloe can be applied to stings and bites to soothe and heal.

    TEA TREE OIL: Tea tree oil is a natural antiseptic and contains many antibacterial, antifungal and antiviral properties. It helps to speed the healing process and is excellent to apply externally on wounds to promote healing and prevent infection. It is also a natural bug repellent and can soothe and promote healing after bites and stings.

    ECHINACEA: One of the most often used herbs, echinacea is useful for pre venting infection by stimulating the immune function. It can be found in herbal salve preparations and applied directly to the wound. A salve can also be applied to skin irritations from contact with poison ivy or oak. LAVENDER: Lavender is a natural bug repellent and can be applied topically to bites and stings.

    GINGER: Ginger root is excellent for an upset stomach. It is effective when used to combat motion and altitude sickness. Studies have found ginger to be just as effective when treating motion sickness due to riding in the car, boating or flying in and airplane, as over the counter remedies which often have side effects such as drowsiness. Ginger can be made into a tea or taken in capsule form. ARNICA: Arnica can be applied externally to areas of bruising and swelling, but not to broken skin. It can help to reduce inflammation.

    PLANTAIN: A poultice of plantain can help reduce inflammation when applied to the affected area. It can also help with bites, stings, scratches and cuts. GARLIC: Along with being a natural antibiotic to help prevent infection, garlic also helps to keep mosquitoes away. They don’t seem to like the scent of garlic. Capsules or pills should be taken internally.

    CAYENNE (CAPSICUM): This is effective for both internal and external bleeding. Externally, apply pressure and raise affected area. Sprinkle cayenne powder over the wound. MINT: Mint leaves, often found growing in the wild, can be made into a tea to help with digestion and calm the nerves. Some members of the mint family include peppermint, spearmint, catnip and horsemint.

    FEVERFEW: This daisy like plant found growing in the wild, can help with migraine headaches and inflammation.

    Chew the leaves, make into a tea or take in capsule form. Some have developed mouth irritations from chewing the leaves.

    Tea Tree Oil Fights Staph Infection

    There is much concern regarding the overuse of antibiotics leading to drug resistant strains of bacteria. Some forms of bacteria are difficult to control as they change form. Tea tree oil holds promise as an effective treatment for inactivating Staphylococcus aureus.

    A study reported in the Journal of Antimicrobial Chemotherapy, (1995; 35: 421-45), and lead by Dr. C. F. Carson, researched tea tree oil at the University of Western Australia. The results were significant. Tea tree oil successfully inactivated the staph bacteria which was resistant to methicillin, a salt of penicillin. It is a versatile substance with a broad spectrum of capabilities. It is generally used topically.

    Blueberries for Health

    Blueberries are packed full of nutritional value. A study published in the Food and Nutrition Re s e a rch Br i e f s , January, 1997, found that two-thirds of a cup of blueberries had more antioxidants than the recommended daily amounts of vitamins E and C. Blueberries were followed by Concord grape juice, strawberries, kale and spinach in their antioxidant content.

    Antioxidants are an important part of optimal health. They protect the body from free radical damage which can lead to a variety of conditions such as aging, cancer, heart disease and other diseases. Adding blueberries could aid in p rotecting the body and strengthening the immune response.

    Worldwide Concern About Antibiotic Overuse

    A recent report called for doctors throughout the world to be careful in administering antibiotics needlessly. Overuse of antibiotics has lead to germ mutations resistant and untreatable with current antibiotics. Pediatricians in the United States have received a brochure from the American Academy of Pediatrics urging them to take precautions before prescribing. Antibiotics are not always the answer as they do not work on viral infections which cause the common cold, sore throats and some ear infections. Staphylococcus aureus is one example of an antibiotic resistant strain. Over 90 percent of this staph strain are resistant to penicillin and other antibiotics. And other bacteria are also developing a resistance to antibiotic therapy. Save antibiotics for conditions that require their use.

    Aloe Vera, Woodland Health Series

    Aloe vera is one of the most widely used plants for medicinal purposes. It has been used for over 4,000 year for its therapeutic benefits. Aloe Vera, a pamphlet written by Deanne Tenney, offers valuable information and up to date research on the aloe vera plant.

    The benefits of the aloe plant are truly amazing. It has been used to treat burns, radiation burns, skin disorders, wounds, scratches, sunburn, dermatitis, constipation, digestion, ulcer, kidney stones, bacterial and viral infections, and to relieve pain. It is widely used for skin disorders, but its benefits go far beyond the skin.

    As a natural home remedy, there are few plants more valuable than the aloe. It is a simple and easy way to treat minor injuries. The plant contains antiseptic, antiviral, antibacterial, anesthetic and tissue healing properties. The Aloe Vera pamphlet offers historical as well as modern uses for this ancient plant. Aloe Vera is available through Woodland Publishing.

    Tea Tree Oil, Woodland Health Series

    Tea tree oil is derived from the leaves of the Melaleuca alternifolia, a shrub-like tree found in Australia. It contains significant medicinal value and beneficial properties. Another pamphlet in the Woodland Publishing Health Series, Tea Tree Oil offers historical uses as well as current scientific information.

    The essential oil of the tea tree leaves is one of the most powerful essential oils. It is used extensively in Australia, and popularity is growing throughout the world. It contains antibacterial, antiviral, and antifungal properties helping to prevent and heal infection.

    Tea tree oil has been used successfully for many conditions such as athlete’s foot, acne, burns, warts, vaginal yeast infections, ringworm, skin rashes, herpes, cold sores, canker sores, insect bites and in preventing infection to name a few. Tea tree oil is a natural alternative that can be used effectively for extended periods of time without.



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    HAWAIIAN NONI (Morinda citrifolia)
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    Date: July 11, 2005 08:50 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: HAWAIIAN NONI (Morinda citrifolia)

    INTRODUCTION

    In a time when we are more concerned than ever with issues of health, a tried and true tropical herb called noni needs t o be added t o our list of the best natural remedies. It susage over hundreds of years supports it s description as a veritable panacea of therapeutic actions. At this writing, noni continues to accrue impressive medicinal credentials, and its emergence as an effective nat ural healing agent is a timely one. Amidst rising cancer rates, the high incidence of degenerative diseases like diabetes, and the evolution of ant ibiotic resist ant bacteria and new viral strains, herbs like noni are sought after for their natural pharmaceutical properties. Unquest ionably, all of us want to know how to:

  • • protect ourselves f rom toxins and pollut ants
  • • prevent t he premature onset of age-related diseases such as arthritis, heart disease, diabetes and stroke
  • • boost our immune defenses to protect ourselves from new viral and bacterial strains that have become antibiotic-resist ant
  • • reduce our risk of developing cancer
  • • better digest our food for proper assimilation and purge the intestinal system wit hout the dangerous side effects of harsh drugs. Its actions are multifaceted and must be considered when assessing natural treatment s for disease or injury. It s impressive and widespread use among various native cult ures of t ropical island regions supports the notion that it does indeed possess valuable, therapeutic compounds.

    Genus Rubiaceae

    Common Names

    Indian Mulberry (India), Noni (Hawaii), Nono (Tahiti and Raratonga), Polynesian Bush Fruit, Painkiller Tree (Caribbean islands), Lada (Guam), Mengkudo (Malaysia), Nhau (Southeast Asia), Grand Morinda (Vietnam), Cheesefruit (Australia), Kura (Fiji), Bumbo (Africa) Note: This is only a small sampling of vernacular names for Morinda citrifolia. Almost every island nation of the South Pacific and Caribbean has a term for this particular plant . This booklet will refer to the herb mainly as “ noni” or M. citrifolia, and is referring primarily to Hawaiin noni.

    Parts Used

    The parts of the noni plant most used for their medicinal and nutritional purposes are the fruit, seeds, bark, leaves, and flowers. Virtually every part of the noni plant is utilized for its individual medicinal properties; however, it is the fruit portion that is regarded as its most valuable. The seeds have a purgative action, the leaves are used to treat external inflammations and relieve pain, the bark has strong astringent properties and can treat malaria, the root extracts lower blood pressure, the flower essences relieve eye inflammations and the f ruit has a number of medicinal actions.

    Physical Description

    Morinda citrifolia is technically an evergreen shrub or bush, which can grow to heights of fifteen to twenty feet . It has rigid, coarse branches which bear dark, oval, glossy leaves. Small white fragrant flowers bloom out of cluster-like pods which bear creamy-white colored fruit. The fruit is fleshy and gel-like when ripened, resembling a small breadf ruit . The flesh of the fruit is characterist ically bitter, and when completely ripe produces a rancid and very dist inctive odor. Noni has buoyant seeds that can float formont hs in ocean bodies. The wood of the inflammatory, astringent, emollient, emmenagogue, laxative, sedative, hypotensive (lowers blood pressure) , blood purif ier, and tonic.

    Chemical Constituents

    Noni has various chemical constituents. First, it has an impressive array of terpene compounds, three of which—L. Asperuloside, aucubin, and glucose— have been identified by their actyl derivatives. Both caproic and caprylic acids have been isolated.1 Second, bushfruits, a category of which noni fruit is a member, are also considered a good source of vit - amin C.2 Third, Hawaiin noni has been linked to the synthesis of xeronine in the body which has significant and widespread health implications. Last , the alkaloid cont ent of the noni fruit is thought to be responsible for its therapeutic actions. Alkaloids exhibit a wide range of pharmacological and biological act ivitiesin the human body. They are nitrogencontaining organic compounds which can react with acids to form salts and which are the basis of many medicines. The following is an in-depth chemical analysis of each plant part and it s chemical constituents.

  • • amino acids (which include alanine, arginine, asparticacids, cysteine, cystine, glycine, glutamic acid, histidine, leucine, isoleucine, methionine, phenylalanine, proline, serine, threonine, tryptophan tyrosine, and valine)
  • • anthraquinones
  • • glycosides
  • • phenolic compounds
  • • resins
  • • B-sitosterol
  • • ursolic acid

    FLOWER

  • • acacet in 7-0-D (+) -glucophyranoside
  • • 5,7,-dimet hylapigenin-4-0-8-D(+) -galactophyranoside
  • • 6,8,-dimet hoxy-3-methyl anthroquinone-1-0-8-rhamnosyl glucophyranoside

    FRUIT

  • • antioxidant
  • • alizarin
  • • anthraquinones
  • • caproic and caprylic acids

    discovered an alkaloid in the Hawaiin noni fruit which he calls proxeronine and which he believes has appreciable physiological actions by acting as a precursor to xeronine, a very crucial compound (see later sections) . In addition, a compound found in the fruit called damnacanthol is believed to help inhibit cert ain viruses and cellular mutations involved in cancer.

    ROOT AND ROOT BARK

  • • carbonate
  • • chlorubin
  • • rubicholric acid
  • • soranjidol
  • • chrysophanol
  • • phosphate
  • • magnesium
  • • ferric iron
  • • sodium
  • • glycosides
  • • morinadadiol
  • • morindine
  • • resins
  • • rubiadin
  • • sterols4

    Pharmacology

    Recent surveys have suggested that noni fruit exerts antibiotic action. In fact, a variety of compounds which have antibacterial properties (such as aucubin) have been identified in the fruit.5 The 6-Dglucopyranose pentaacet ate of the fruit extract is not considered bacteriostatic.6 Constituents found in the fruit portion have exhibited ant imicrobial action against Escherichia coli, Salmonella typhi (and other types) , Shigella paradysenteriae, and Staphylococcus aureaus. Compounds found in the root have the ability to reduce swollen mucous membrane and lower blood pressure in animal studies. Proxeronine is an alkaloid constituent found in Hawaiin noni fruit which may prompt the production of xeronine in the body. It is considered a xeronine precursor and was discovered in noni fruit by Dr. Ralph M. Heinicke. He has theorized that this proenzyme can be effective in initiating a series of beneficial cellular reactions through its involvement with the integrity of specific proteins. He points out that tissues contain cells which possess certain recept or sites for xeronine. Because the reactions that can occur are so varied, many different therapeutic actions can result when xeronine production escalates, explaining why Hawaiin noni is good for so many seemingly unrelated disorders. Damnacanthol is another compound contained in the fruit of the Hawaiin noni plant which has shown the ability to block or inhibit the cellular function of RAS cells, considered pre-cancerous cells.

    Body Systems Targeted

    The following body systems have all been effec-freeze-dried capsules, dehydrated powder or fruit, and oil. Noni plant constituents are sometimes offered in combination with other herbs. Some products contain a percent age of the fruit, bark, root and seeds for their individual therapeutic properties.

    Satety

    Extracts of M. citrifolia are considered safe if used as directed; however, pregnant or nursing mothers should consult their physicians before taking any supplement . High doses of root extracts may cause constipation. Taking noni supplements with coffee, alcohol or nicotine is not recommended.

    Suggested Uses

    Ideally, noni extracts should be taken on an empty stomach prior to meals. The process of digesting food can interfere with the medicinal value of the alkaloid compounds found in Hawaiin noni, especially in its fruit . Apparently, stomach acids and enzymes destroy the specific enzyme which frees up the xeronine compound. Take noni supplements without food, coffee, nicotine or alcohol. Using supplements that have been made from the semi-ripe or light - green fruit is also considered preferable to the ripe, whit ish fruit .

    NONI: ITS USE AND HISTORY

    Noni is a tropical wandering plant indigenous to areas of Australia, Malaysia and Polynesia. It is considered native to Southeast Asia although it grows from India to the eastern region of Polynesia. Morinda citrifolia has a long history of medicinal use throughout these areas. It is thought to be the “most widely and commonly used medicinal plant prior to the European era.” 7 Centuries ago, the bushfruit was introduced to native Hawaiians, who subsequently called it “noni” and considered its fruit and root as prized medicinal agents. Among all Polynesian botanical agents of the 19th and 20th centuries, Hawaiin noni has the widest array of medical applications. Samoan and Hawaiian medical practitioners used noni for bowel disorders (especially infant diarrhea, constipation, or intestinal parasites) , indigestion, skin inflammation, infection, mouth sores, fever, contusions and sprains. Hawaiians commonly prepared noni tonics designed to treat diabetes, stings, burns and fish poisoning.8 The herb’s remarkable ability to purge the intestinal tract and promote colon health was well known among older Hawaiian and Tahitian natives and folk healers. Interestingly, field observations regarding its repu-remarkable healing agent .

    Wonder Herb of Island Folk Healers

    Common to t he thickets and forests of Malaysia and Polynesia, and the low hilly regions of the Philippine islands, noni has been cultivated throughout communities in the South Pacific for hundreds of years. Its Hawaiian use is thought to originate from inter-island canoe travel and settlement dating to before Christ . Its hardy seeds have the ability to float which has also contributed to its distribution among various seacoasts in the South Pacific region. Historical investigation has established the fact that some of Hawaii’s earliest settlers probably came viaTahiti. For this reason, Tahitian herbal practices have specific bearing on the herbal therapeutics of islands to the nort h. The very obvious similarities between the Hawaiian vernacular for herbal plants like noni and Tahitian names strongly suggests the theory of Polynesian migrations to Hawaii. Cultures native to these regions favored using Morinda citrifolia for treating major diseases and ut ilized it as a source of nourishment in times of famine.9 Noni fruit has been recognized for centuries as an excellent source of nutrition. The peoples of Fiji, Samoa and Rarat onga use the fruit in both its raw and cooked forms.10 Traditionally, the fruit was propicked before it was fully ripe and placed in the sunlight . After being allowed to ripen, it was typically mashed and its juice extracted through a cloth. Noni leaves provided a veget able dish and their resiliency made them desirable as a fish wrap for cooking.

    Noni’s Medical Reputation

    Elaborate traditionalrituals and praying rites usually accompanied the administration of noni. Int erestingly, cultures indigenous to the Polynesian islands had a significant understanding of their flora. For example, native Hawaiians maint ained a folkmedicine taxonomy t hat was considered second to none.11 Noni was not only used for medicinal purposes but for its food value, for clot hing and for cloth dyes as well. Research indicates that noni was among the few herbal remedies that islanders considered “ tried and true.” In Hawaii, trained herbal practitioners reserved the right to prescribe plant therapies.12 Records indicate that Hawaiian medical practices were based on extensive and very meticulous descriptions of symptoms and their prescribed herbal treatments. Dosages were controlled and the collection and administration of plant extracts was carefully monitored.13 In addition to Morinda, it was not uncommon for these herbal doctors to also recommend using In regard to its application for common ailments, Hawaiians and other island communities traditionally prescribed noni to purge the bowel, reduce fever, cure respiratory infections such as asthma, ease skin inflammations, and heal bruises and sprains. In other words, noni was widely used and highly regarded as a botanical medicine.

    A Timely Reemer gence

    Today, the natural pharmaceutical actions of the chemical constituents contained in noni are scientif-ically emerging as valuable bot anical medicines. Tahitian “nono” intrigued medical practitioners decades ago; however, due to the eventual emergence of synthetic drugs, interest in this island botanical diminished until recent years. Ethnobot anists are once again rediscovering why Hawaiian people havet reasured and cultivat ed Morinda citrifolia for generations. Noni is now finding its way into western therapeutics and is referred to as “ the queen” of the genus Rubiaceae. Its ability to reduce joint inflammation and target the immune system have made it the focus of the modern scientific inquiry. Dr. Ralph Heinicke has conducted some fascinating studies on the chemical constituents of the Hawaiin noni fruit. His research centers on the proxeronine content of the fruit juice and how it profoundly influences human physiology. In addition, scientific studies investigating noni as an anti-cancer agent have been encouraging. It s conspicuous attributes and varied uses have elevat edits status to one of the best of the healing herbs. Today Morinda citrifolia is available in liquid, juice, freezedried capsules, or oil forms, and is considered one of nature’s most precious botanicals.

    TRADITIONAL USES OF NONI

    Throughout tropical regions, virtually every part of Morinda citrifolia was used to treat disease or injury. Its curative properties were well known and commonly employed. PatoaTama Benioni, a member of the Maoritribe from the Cook Islands and a lecturer on island plants explains: Traditionally Polynesians use noni for basically everything in the treatment of illness. Noni is a part of our lives. Any Polynesian boy will tell you he’s had exper ience with it . We use juice from its roots, its flowers, and its fruit... my grandmother taught me to use noni from the roots and the leaves to make medicine for external as well as internal use, and for all kinds of ailments, such as coughs, boils, diseases of the skin, and cuts.15

    decoctions to stimulate delayed menst ruation.

  • • Noni was frequently utilized for its antiparasitic activity.
  • • Respiratory ailments, coughs, and colds were treated with noni.
  • • A juice made from pounding noni leaves, roots and fruit mixed with water was administered for diarrhea.
  • • Dried and powdered forms of the bark mixed with water and administ ered with a spoon treated infant diarrhea.
  • • Small pieces of fruit and root infused with water were given to kill intestinal parasites.
  • • Boiled bark decoctions were given as a drink for stomach ailments.
  • • Coughs were treated with grated bark.
  • • Charred unripe fruit was used with salt on diseased gums.
  • • Pounded fruit combined with kava and sugar cane was used to treat tuberculosis.
  • • Babies were rubbed with fresh, crushed leaves for serious chest colds accompanied by fever.
  • • Eye washes were made from decoctions for eye complaint s from flower extracts.
  • • Leaf infusions were traditionally taken to treat adult fevers.
  • • A mouthwash consisting of crushed ripe fruit and juice was used for inflamed gums in young boys.
  • • Pounded leaf juice was used for adult gingivitis.
  • • Sore throats were treated by chewing the leaves and swallowing the juice.
  • • Skin abscesses and boils were covered with leaf poultices.
  • • Swelling was controlled with leaf macerations.
  • • Heated leaves were often used for arthritic joins and for ringworm.16

    XERONINE: THE SECRET OF NONI?

    One informed professional on the subject of noni is Dr. Ralph Heinicke, a biochemist who has researched the active compounds of noni fruit for a number of years. He discovered that the Hawaiin noni fruit contains an alkaloid precursor to a very vital compound called xeronine. Wit hout xeronine, life would cease. In Dr. Heinicke’s view, noni fruit provides a safe and effective way to increase xeronine levels, which exert a crucial influence on cell health and protction. His research suggests that the juice from the M. citrifolia fruit contains what could technically be considered a precursor of xeronine—proxeronine. This compound initiates the release of xeronine in the intestinal tract after it comes in contact with a specific enzyme which is also contained in the fruit .

    Because proteins and enzymes have so many varied roles within cell processes, the normalization of these proteins with noni supplemenation could initiate avery wide variety of body responses and treat many disease condit ions. Proteins are the most important catalysts found in the body. The beauty of obtaining a precursor to xeronine from the noni fruit is that the body naturally decides how much of this precursor to convert to xeronine. Disease, stress, anger, trauma and injury can lower xeronine levels in the body, thus creat ing a xeronine deficit . Supplementing the body with noni fruit is considered an excellent way to safely and naturally raise xeronine levels. It is the research and theories of Dr. Heinicke which have made the juice of the Hawaiin noni fruit a viable medicinal substance. He writes: Xeronine is analkaloid, a substance the body produces in order to activate enzymes so they can function properly. It also energizes and regulates the body. This par-ticular alkaloid has never been found because the body makes it, immediately uses it, and then breaks it down. At no time is there an appreciable, isolable amount in the blood. But xeronine is so basic to the functioning of proteins, we would die without it . Its absence can cause many kinds of illness.17 Because so many diseases result from an enzyme malfunction, Dr. Heinicke believes that using the noni fruit can result in an impressive array of curative applications. Interestingly, he believes that we manufacture proxeronine while we are sleeping. He proposes t hat if we could constantly supply our bodies wit h proxeronine from other sources, our need to sleep would diminish.18

    NONI PROCESSING

    How an herb is processed is crucial to how beneficial it is: this is especially true of noni, with its unique enzymes and alkaloids. Morinda citrifolia should be picked when the fruit is turning from its dark green immature color to its lighter green color, and certainly before it ripens to its white, almost translucent color. Once picked, noni, like aloe, will denature extremely quickly due to its very active enzymes. After harvesting, it should swiftly be flash frozen. This is similar to what is done to fish caught at sea to keep them f esh. This stops it from losing its potency while not damaging any of its constituents. To process noni, freeze-drying is recommended. This removes only the water without damaging any of this miracle plant’s vital enzymes and other phytonutrients like xeronine and proxeronine. This pure high-quality noni fruit juice powder is then encapsu-has a very harsh taste and an extremely foul smell, similar to the fruit it self . Other methods of processing include thermal processing, dehydrat ion and air drying. Thermal processing is generally found in liquids, while the dehydrat ed noni is then milled and encapsulated. Unfortunately both methods utilize high heat (110+°F) , which can deactivate many of the vital compounds that make noni so import ant . Air-drying is effect ive without using damaging heat but has serious quality control problems for commercial production.

    MODERN APPLICATIONS OF NONI

    Overview

    Noni possesses a wide variety of medicinal properties which originat e from its differing plant component s. The fruit and leaves of the shrub exert antibacterial activities. Its roots promote the expulsion of mucus and the shrinkage of swollen membranes making it an ideal therapeutic for nasal congest ion, lung infect ions, and hemorrhoids. Noni root compounds have also shown natural sedative properties as well as the ability to lower blood pressure.

    Leaf extracts are able to inhibit excessive blood flow or to inhibit the formation of blood clots. Noni is particularly useful for its ability to treat painful joint conditions and to resolve skin inflammations. Many people drink noni fruit extracts in juice form for hypert ension, painful menstruation, arthritis, gastric ulcers, diabetes, and depression. Recent studies suggest that its anticancer activit y should also be considered. Concerning the therapeutic potential of the Hawaiin noni fruit, Dr. Heinicke writes: I have seen the compound found in noni work wonders. When I was still investigating its possibilities, I had a friend who was a medical research scientist administer the proxeronine to a woman who had been comatose for three months. Two hour safter receiving the compound, she sat up in bed and asked where she was. . . . Noni is probably the best source of proxeronine that we have today.19 Studies and surveys combined support the ability of noni to act as an immunost imulant, inhibit the growth of certain tumors, enhance and normalize cellular function and boost tissue regeneration. It is considered a powerful blood purifier and contributor to overall homeostasis.

    xeronine, which appears to be able to regulate the shape and integrity of cert in proteins that individually contribute to specific cellular activities. Interestingly, this effect seems to occur after ingestion, inferring that the most active compound of noni may not be present in uneaten forms of the fruit or other plant parts. Some practitioners believe that xeronine is best obtained from a noni fruit juice precursor compound. The enzymatic reactions that occur with taking the juice on an empty stomach are what Dr. Heinicke believes set cellular repair intomotion.

    Cancer

    A study conducted in 1994 cited the anticancer activity of Morinda citrifolia against lung cancer. A team of scientists from the University of Hawaii used live laboratory mice to test the medicinal properties of the fruit against Lewis lung carcinomas which were artificially transferred to lung tissue. The mice that were left untreated died in nine to twelve days. However, giving noni juice in consistent daily doses significantly prolonged their life span. Almost half of these mice lived for more than fifty days.20 Research conclusions state that the chemical constituents of the juice acted indirectly by enhancing the ability of the immune system to deal with the invading malig-nancy by boosting macrophage or lymphocyte activit y. Furt her evaluation theorizes that the unique chemical constituents of Morinda citrifolia initiate enhanced T-cell activity, a reaction that may explain noni’s ability to treat a variety of infectious diseases. 21

    In Japan, similar studies on tropical plant extracts found that damnacanthol, a compound found in Morinda citrifolia, is able to inhibit the function of KRAS- NRK cells, which are considered precursors to certain types of malignancies.22 The experiment involved adding noni plant extract to RAS cells and incubating them for a number of days. Observation disclosed that noni was able to significantly inhibit RAS cellular function. Among 500 plant extracts, Morinda citrifolia was determined to contain the most effective compounds against RAS cells. Its damnacanthol content was clinically described in 1993 as “a new inhibit or of RAS function.” 2 3 The xeronine fact or is also involved in that xeronine helps to normalize the way malignant cells behave. While they are still technically cancer cells, they no longer function as cells with unchecked growth. In time, the body’s immune system may be able to eradicate these cells.

    Arthritis

    with arthritic disease. One link to arthritic pain may be the inability to properly or completely digest proteins which can then form crystal-like deposits in the joints. The ability of noni fruit to enhance protein digestion through enhanced enzymatic function may help to eliminate this particular phenomenon. In addition, the alkaloid compounds and plant met abolites of noni may be linked to its apparent anti-inflammatory action. Plant sterols can assist in inhibiting the inflammatory response which causes swelling and pain. In addition, the antioxidant effect of noni may help to decrease free radical damage in joint cells, which can exacerbate discomfort and degeneration.

    Immune System

    The alkaloid and other chemical compounds found in noni have proven themselves to effectively control or kill over six types of infectious bacterial strains including: Escherichia coli, salmonellatyphi (and other types) , shigella paradysenteriae, and staphylo - coccus aureaus.25 In addition, damnacanthol, was able to inhibitt he early antigen stage of the Epstein- Barr virus.

    The bioactive components of the whole plant, combined or in separate portions, have demonst rat - ed the ability to inhibit several different strains of bacteria. Anecdotal reports support this action in that noni seems particularly effective in shortening the duration of certain types of infection. This may explain why noni is commonly used to treat colds and flu. The chemical constituents found in noni and the possibility that they stimulate xeronine production— as well as initiate alkaloid therapy—may explain noni’s reputation for having immuno-stimulatory properties. Alkaloids have been able to boost phagocytosis which is the process in which certain white blood cells called macrophages attack and literally digest infectious organisms. Interestingly, the ant it umoraction of noni has been ascribed to an immune system response which involves stimulating T-cells. tropical regions during World War II learned of the fruit’s ability to boost endurance and stamina. Native cultures in Samoa, Tahiti, Raratonga and Australia used the fruit in cooked and raw forms. M. citrifolia is considered a tonic and is especially recommended for debilitated conditions.

    Antioxidant

    The process of aging bombards the body with free radicals which can cause all kinds of degenerative diseases. The xeronine theory promoted by Dr. Heinicke submit s t hat as our bodies age, we lose our ability to synthesize xeronine. To make matters worse, the presence of many environment altoxins actually blocks the production of xeronine as well. He believes that the proxeronine content of Hawaiin noni fruit juice can help to block these actions, thereby working as an antiaging compound.26 The phytonutrients found in noni assist in promot - ing cell nourishment and prot ect ion from free radicals created by exposure to pollution and other potentially damaging agents. In addition, Morinda citrifolia contains selenium, which is considered one of the best antioxidant compounds available.

    Diabetes

    While scientific studies are lacking in this particular application of noni, Hawaiians used various parts of the plant and its fruit to treat blood sugar disorders. Anecdotal surveys have found t hat noni is current ly recommended for anyone with diabetes.

    Pain Killer

    A 1990 study found that extracts derived from the Morinda citrifolia root have the ability to kill pain in animal experiments.27 Interest ingly, it was during this study that the natural sedative action of the root was also noted. This study involved a French team of scientists who noted a significant central analgesic activity in laboratory mice.28 Dr. Heinicke has stated, “Xeronine also acts as a pain reliever. A man wit h very advanced int est inal cancer was given three months to live. He began taking the proxeronine and lived for a whole year, pain-free.” 29

    Skin Healing Agent

    One of the most prevalent hist rical uses of noni was in poultice form for cuts, wounds, abrasions, burns and bruises. Using its fruit extract for very serious burns has resulted in some extraordinary healing. Because skin is comprised of protein, it immediately responds to the presence of xeronine.

    burn site throught he direct application of a noni poultice is considered quite effective by Dr. Heinicke and his colleagues, who have studied enzymatic therapy. Concerning burns, he has written: I believe that each tissue has cells which contain proteins which have receptor sites for the absorption of xeronine. Certain of these proteins are the inert for ms of enzymes which require absorbed xeronine to become active. This xeronine, by converting the body’s procol- langenase system into a specific protease, quickly and safely removes the dead tissue from burns.30

    Drug Addiction

    The xeronine link to treat ing drug addiction is based on the notion that flooding t he brain with extra xeronine can reverse the neurochemical basis for addiction. This natural alkaloid is thought to normalize brain receptors which subsequent ly results in the cessation of physiological dependence on a certain chemical like nicotine.3 1 The potential of Hawaiin noni as a natural stimulat or for t he production of xeronine may have profound implications in treating various types of addictions.

    Complementary Agents of Noni

  • cat’s claw papaya
  • kava kava
  • pau d’arco
  • bioflavonoids
  • selenium
  • germanium
  • grapeseed extract
  • echinacea
  • proteolytic enzymes
  • aloe vera
  • glucosamine
  • shark
  • cartilage

    PrimaryApplications of Noni

  • abrasions
  • arthritis
  • atherosclerosis
  • bladder infections
  • boils bowel disorders
  • burns cancer
  • chronicfatigue syndrome
  • circulatory weakness
  • colds congest ion
  • cold sores constipation
  • depression diabetes
  • eye inf lammations fever
  • fract ures gastric ulcers
  • gingivit is headaches
  • high blood pressure immune
  • weakness
  • indigestion intestinal parasites
  • kidney disease menstrual



    --
    Vitanet ®

    Solaray - Ultimate Nutrition - Actipet Pet supplements - Action Labs - Sunny Greens - Thompson nutritional - Natural Sport - Veg Life Vegan Line - Premier One - NaturalMax - Kal

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    GLISODIN POWER - Superoxide Dismutase (SOD)
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    Date: June 29, 2005 10:54 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: GLISODIN POWER - Superoxide Dismutase (SOD)

    Most people know that antioxidants found in food are critical for health and longevity, but did you know that the human body has its own antioxidant defense system? Superoxide dismutase (SOD) is an internal antioxidant manufactured by the body as the first line of defense against free radical damage. Unfortunately, high levels of stress and exposure to environmental and dietary toxins can deplete our antioxidant stores, leaving us more susceptible to chronic health challenges. When we are young and healthy the body unleashes its own antioxidants, but as we age this internal antioxidant producing system declines and the body needs help.

    Source Naturals introduces GLISODIN POWER, an innovative approach to antioxidant supplementation. Scientific research shows that GliSODin® supports the body’s own production of superoxide dismutase. GLISODIN POWER is a patented, orally effective, 100% vegetable compound comprised of gliadin, a wheat protein extract bound to superoxide dismutase derived from canteloupe.

    Oxygen is required by your cells to generate energy, but it also contributes to oxidative stress or free radical damage, which is one of the primary causes of age-related damage to your cells and tissues. Free radicals have unpaired electrons that can damage living cells and compromise the proper function of tissues and organs. Antioxidants make free radicals stable by providing them with an additional electron. Unfortunately, now the antioxidant is missing an electron so, ironically, it becomes a free radical, which requires another antioxidant to donate an electron. Because this process starts a cascade of free radicals, scientists strongly recommend a broad range of antioxidants to minimize this negative effect.

    First Line of Defense

    There are two classes of antioxidants-external and internal. External antioxidants are supplied to the body by the foods we eat or the supplements we take. They include vitamins A, C and E, selenium, and other antioxidants found in fruits and vegetables. Internal antioxidants are naturally present in every cell of your body. The internal antioxidant defense system includes the enzymes superoxide dismutase (SOD), catalase and glutathione peroxidase. They are the first line of defense against oxidative stress. SOD transforms the superoxide radicals into ions that are less reactive. The superoxide radicals, which are byproducts of normal cell processes, can damage cells if their levels are not controlled. The other enzymes then transform the less reactive ions in a process called dismutation. The superoxide dismutase enzyme gets its name from this process. Research indicates that SOD plays an important role in protecting neurons from oxidative damage.

    Super Antioxidant: SOD

    SOD levels decline with age, while free radical production increases. SOD occurs naturally in barley grass, broccoli, Brussels sprouts, cabbage, wheat grass, melon and most green plants. Unfortunately, when taken orally the SOD enzyme is usually destroyed in the digestive process. GliSODin is a new form of SOD that withstands the digestive process and promotes SOD production by the body. This breakthrough technology combines a vegetable source of SOD extracted from melon with gliadin, a wheat protein. Scientific studies have shown that GliSODin promotes the natural production of SOD in the body. Research has also shown that it protects against oxidative stress and provides an optimal defense against free radicals.

    Wellness Revolution

    Innovative natural products such as GLISODIN POWER, are part of the Wellness Revolution. Taking personal responsibility for your health is at the heart of this revolution. Your local health food outlet is your source for nutritional education and quality products. Source Naturals is pleased to partner with these outlets to bring you the groundbreaking nutritional science of GLISODIN POWER.

    References:
    Vouldoukis, I. et al. Oral supplementation of the antioxidant enzyme superoxide dismutase in Wheat Gliadin Biopolymers promotes the antioxidant defense system. Bernard Dugas, Isocell Nutra, 53 bd du General Martial Valin, 75015 Paris, France. (Article submitted to the American Journal of Clinical Nutrition, Jan 2002). Claus, M et al. 2004. Oral SOD and oxidative cell stress: Influence of an orally effective SOD on hyperbaric oxygen-related cell damage. Free Radical Research 38 (9): 927-932. Stella, V. et al. 1995. Gliadin films. I. Preparation and in vitro evaluation as a carrier for controlled drug release. International Journal of Pharmaceutics 121: 117-121. Isocell SA, France is the owner of US Patent Nos. 6,045,809 and 6,426,068B1 and trademark for GliSODin®.



    --
    Vitanet ®

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    Colo-rectal Cancer and Fat
    TopPreviousNext

    Date: June 25, 2005 07:36 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Colo-rectal Cancer and Fat

    Colo-rectal Cancer and Fat

    Dietary fat intake has been closely related to the incidence of colon cancer in this country.19, 20 “Diet is probably the major determinant of the risk of colo-rectal cancer; there is evidence that fruit and vegetables and fiber reduce risk and that meat and animal fat increase risk[.]”20 Due to the action of intestinal microflora, undigested meats and fats can be chemically altered to form carcinogenic chemicals chich can damage the lining of the colon and promote the formation of cell mutations.21 Again the case for a high-fiber, low-saturated-fat diet is evident.

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    CANCER TREATMENT AND PREVENTION WITH GARLIC
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    Date: June 25, 2005 10:14 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: CANCER TREATMENT AND PREVENTION WITH GARLIC

    CANCER TREATMENT AND PREVENTION WITH GARLIC

    One of the most exciting aspects of the therapeutic value of garlic lies in its potential use as an anti-cancer agent. Several animal experiments have suggested that Garlic can inhibit or even reverse the growth of certain tumors.

    One in three people will develop cancer at some time during their life and one in five will die from it. Cancer ranks second only to heart disease as a leading cause of death in the United States. Projections put cancer as the number one killer of Americans sometime after the year 2000. While cancer research has spent millions of dollars searching for the elusive cure, thousands continue to die from cancer. Garlic has finally caught the attention of cancer research and is currently under scrutiny for its anti-carcinogenic properties.

    Several laboratory tests have found that certain enzymes contained in some cancers are totally inhibited by alliinase and other compounds contained in garlic. Several Japanese experiments suggest that injecting garlic into rats with certain types of sarcoma blocked tumor cell reproduction and caused mutations in the cancer cells themselves.38

    As is the case with other infectious diseases, garlic’s role in simulating the body’s immune defenses may also be linked to cancer control and prevention. Because garlic helps to mobilize the immune system, carcinogens which may initially begin tumor formation may be attacked and destroyed by heightened immune function. Because garlic enhances the action of the body’s natural killer cells, it boosts their ability to attack tumor cells before cancers can develop. In laboratory tests, the natural killer cells of garlic-eating subjects destroyed 159 percent more tumor cells than those who had not consumed garlic.39

    “In animal studies by Weisberger and Pensky of Western Reserve University, as reported in Science, mice injected with cancer cells died within 16 days. When cancer cells were treated with Garlic extract and injected into the animals, no deaths occurred for a period of 6 months. In other studies, feeding fresh Garlic to female mice completely inhibited the development of mammary tumors.”40

    Studies in cancer Research in the Journal of the National Cancer Institute reveal that stomach cancer risk was significantly reduced with the consumption of allium vegetables including garlic and scallions. The high germanium content of garlic may also play a role in cancer treatment and prevention. At this writing, continuing research unfolds on garlic and its effect on cancer cells. The National Cancer Institute is planning a study of garlic’s role as a cancer-preventing agent. The study was planned after reports indicated that people who live in China and Italy and eat a lot of garlic seem to enjoy a certain degree of protection against stomach cancer.

    Dr. William J. Blot of the Institute stated that these people eat a lot of garlic and related vegetable such as scallions and onions, a habit that correlates with a lower incidence of stomach cancer.41

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    CLINICAL APPLICATIONS OF CAPSICUM
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    Date: June 23, 2005 11:20 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: CLINICAL APPLICATIONS OF CAPSICUM

    CLINICAL APPLICATIONS OF CAPSICUM

    Capsicum is a remarkable whole body stimulant that can boost blood flow, tone the nervous system, relieve indigestion, promote sweating, help to cauterize and heal ulcers, ease persistent pain and fight off infection. One very authoritative work on African plants suggests that Capsicum’s “regular ingestion is highly beneficial in hemorrhoids, varicose veins, anorexia, liver congestion and vascular conditions . . .the indigenous inhabitants of Africa and of the Antilles are remarkably free form all of these conditions as they use Capsicum fruit in their diet.”10 Most of the therapeutic actions of Capsicum are attributed to the alkaloid or glucoside content of the herb.11 The latest scientific studies conducted with Capsicum will be discussed in subsequent sections.

    Herbal Catalyst

    Because Capsicum boosts peripheral circulation and stimulates organ secretion, it expedites the therapeutic delivery and action of other herbs. In other words, the medicinal benefits of these herbs reach infected or inflamed tissue more rapidly due to enhanced blood flow.12 Consider the following statement: “Cayenne will insure the rapid and even distribution of the active principles of the rest of the herbs to critical function - al centers of the body, including those involved in cellular respiration, metabolism, data transmission, and neural-hormonal activation. Cayenne is included in several other blends for this reason. In extremely small quantities it can dramatically increase the efficiency of most other herbs.”13 Many health practitioners believe that the key to healing is CAPSICUM stimulation. Capsicum stimulates eve rything from blood flow to peristaltic action in the stomach, to intestinal transit time. The re m a rkable ability of Capsicum to stimulate organ secretion and even heart action makes it one of the strongest natural stimulants known. Se veral different kinds of herbal blends targeting various body systems will utilize Capsicum to boost the formula’s efficacy.

    Cardiovascular Tonic

    Capsicum is said to be unequaled for its ability to boost circulation and increase heart action. Interestingly, cultures who consume significant amounts of cayenne pepper in their diet have much lower rates of cardiovascular disease.14 Capsicum exerts a variety of desirable actions on the entire card i ovascular system. It has the extraordinary ability to enhance cardiovascular performance while actually lowering blood pressure.15 A quote taken from a card i ovascular publication re a d s , “Capsaicin has also been shown to prolong cardiac action potential in atrial muscle . . .”16 Michael T. Murray, N.D., has stated, “ Cayenne pepper [Capsicum] should be recommended as a food for its beneficial antioxidant and cardiovascular effects.”17 Herbalists have considered Capsicum as a superior “f o o d” for the heart. In fact, in cases where a heart attack is suspected administering capsicum in hot water has been thought to help lessen the severity of the attack. Capsicum can also be placed on or under the tongue in emergencies involving heart attack, stroke or hemorrhaging. 18 Note: Using Capsicum for any heart-related problem, especially a suspected heart attack should never take the place of medical attention or a physician’s care.

    CAPSICUM Blood Cholesterol Reducer

    Various studies have conclusively demonstrated that Capsicum reduces the risk of developing atherosclerosis (hardening of the a rteries) by reducing blood cholesterol and triglyceride levels .19 Additional clinical studies conducted in India found that when cayenne was ingested along with dietary cholesterol, the typical rise in liver and blood serum cholesterol levels was significantly inhibited. In addition, bile acids and free cholesterol were subsequently eliminated from the body through the stool.20 Interestingly, these tests revealed that using Capsicum was actually more effective in reducing cholesterol that capsaicin alone.2 1 Daniel Mowrey, Ph.D., emphatically points out that this is just one of many examples of the superiority of whole botanicals as opposed to their isolated components.22 Note: Using Capsicum in combination with Hawthorn is a particularly good cardiovascular tonic.

    Blood Pressure Equalizer

    While an added bonus of Capsicum’s capability to lower blood serum cholesterol is a decrease in blood pressure, additional evidence strongly suggests that the herb initiates other mechanisms that fight hypertension .23 “Cayenne, according to another study, also reduces the blood pressure in an even more direct manner: a number of years ago, a team of researchers discove red that capsaicin acts in a reflexive manner to reduce systemic blood pressure, a kind of coronary chemoreflex.”24 Adding Garlic to Capsicum creates an even better therapeutic blend for treating hypertension.

    Blood Detoxification CAPSICUM

    “Cayenne is a kind of catalyst in the blood purification process . . . it acts as a diaphoretic, stimulating the excretion of wastes in the swe a t . ”25 Because Capsicum stimulates organ secretion and boosts peripheral blood flow, it would only stand to reason that it would also facilitate the faster removal of toxins from the bloodstream and lymphatic system. You may have already noticed that Capsicum is frequently added to blood-purifying herbal combinations. Circulatory Booster Researchers have found that the simulating action of Capsicum on surface capillaries can help to pre vent cold hands and feet.2 6 For this reason, it may be helpful for Reynaud’s Syndrome. Old remedies using Capsicum have even recommended placing it in socks to warm the feet and to help prevent frostbite. An old folk cure for a chilled body was a steaming hot cup of Capsicum tea. Free Radical Scavenger The rich flavonoid content of Capsicum gives it significant antioxidant capabilities. A recent study conducted in 1995 showed that Capsicum has a higher ascorbic acid content than chiles from the jalapeno or serrano varieties .27 Vitamin C and bioflavonoids can scavenge for dangerous free radicals which cause tissue damage and can predispose organs to degenerative diseases. Free radicals are found everywhere and are created as by-products of metabolic p rocesses including the act of breathing itself. Pollutants can expose the body to free radicals. An interesting study done in Mexico City and published in 1993 found that Capsicum extract was able to modulate the mutagenic activity of urban air samples.28 In other words, these potentially dangerous nitro - a romatic compounds found in polluted air were kept from mutating by red chile extract.29 Chemical breakdowns of Capsicum have also found that CAPSICUM the pepper is high in Provitamin A, which significantly contributes to its healing ability and immune fortification.30 Anti-Carcinogenic Compound Anti-cancer research recently tested Capsicum on laboratory rats and found that it does indeed demonstrate anti-cancer properties by inhibiting certain enzymes which can initiate the mutation of cells.31 What this implies is that taking Capsicum can afford the body some protection against the cellular mutation which occurs in malignant growths. Capsicum actually inhibited the formation of dangerous metabolites under laboratory conditions where they should have normally been activa t e d .3 2 This study implies that Capsicum may have many more sophisticated bio-chemical actions than previously thought.

    An Impressive Pain Killer

    Capsaicin has recently emerged as a remarkably effective pain reliever and has become the subject of recent clinical research . Applying capsaicin in cream or ointment form to painful joints, scar tissue or other painful conditions involving peripheral nerves confuses pain transmitters. In other worlds, capsaicin temporarily disrupts sensory nerve cell biochemistry there by impeding the relay of pain sensations from the skin surface. It does this by inhibiting a neurotransmitter called substance P. This specific compound is thought to be the main mediator of pain impulses from peripheral nerve endings.33 Substance P has also demonstrated its ability to inhibit inflammatory pain generated in arthritic joints in much the same way.34 Today, several over-the-counter topical preparations utilize capsaicin for the pain of arthritic joints. The ability of Capsicum to control severe and unresponsive pain is significant, to say the least. Modern clinical utilization of topical capsaicin may offer signifi-cant relief for a number of painful conditions including: diabetic neuropathy, cluster headaches, post-amputation pain, post-mastectomy pain, shingles and painful scar tissue.35

    POST-SURGICAL PAIN

    In the early spring of 1996, prime time national news show s reported that scientists had found that individuals who had suffered from chronic pain in post-surgical scars (heart bypass, arterial grafts, etc.) were successfully treated with topical preparations containing capsaicin. While this may have been news to many of us, clinical studies had been already published for several years that capsaicin held profound value for various kinds of pain which did not respond to established medical treatments. Typically surgical scars and regions around them can produce persistent pain or can be very sensitive to the touch even when completely healed. This type of pain phenomenon seems to respond well to capsaicin ointments and creams.

    POST-MASTECTOMY PAIN

    When capsaicin preparations were applied following mastectomy or breast reconstruction, pain was significantly relieved. Se veral double blind studies found that using capsaicin creams four times daily for 4 to 6 weeks resulted in much less frequent occurrence of sharp, jabbing pain.3 6 All thirteen patients studied had a 50 percent or greater improve m e n t .3 7 Various unpleasant sensations other than pain also improved with topical applications of capsaicin creams.38

    MOUTH SORES FROM RADIATION OR CHEMOTHERAPY

    A fascinating study conducted at the Yale Pain Management Center discove red that capsaicin could ve ry significantly lessen pain caused by mouth sores which frequently develop after chemotherapy or radiation.39 Apparently delivering the capsaicin in the form of soft candy (taffy) enabled the substance to be retained in the mouth long enough to desensitize the nerve endings causing the pain. Each one of the eleven case studies re p o rted that their pain had decreased and in two patients, it stopped entirely.40

    DIABETIC NEUROPATHY

    Diabetic neuropathy is a painful nerve condition which can develop in cases of prolonged diabetes. Several double-blind studies have supported the considerable value of capsaicin creams for relieving the pain associated with this disorder.41 The results of a controlled study using Capsicum for seve re cases of diabetic neuropathy which did not respond to conventional therapy were published in 1992. A cream containing Capsicum was applied to painful areas four time a day and pain was carefully e valuated for 8 weeks at two-week intervals. The results we re impressive, to say the least. In the 22 patients who used the Capsicum the following results we re re c o rded: “Capsaicin tre a tment was more beneficial than vehicle treatment in the overall clinical improvement of pain status, as measured by physician’s global evaluation and by a categorical pain severity scale . . . In a follow-up study, approximately 50 percent of the subjects reported improved pain control or were cured . . .”42 No t e : While there was a burning sensation when the Capsicum c ream was first applied, some subjects found that its magnitude and duration lessened with continued application.43

    SHINGLES

    The FDA has approved capsaicin-based ointments for the treatment of pain that results from diseases like shingles. Again, numerous studies have documented the value of capsaicin for decreasing the miserable nerve-related pain associated with shingles. The general consensus derived from these tests were that approximately 50 p e rcent of people suffering from shingles responded well to capsaicin creams, some even after 10 to 12 months.44

    Note: If blisters accompany a shingles outbreak, it is better to wait until they have healed before using any capsaicin-based ointments or creams.

    RELIEF FOR BURNING FEET

    Frequently an uncomfortable “burning” sensation in the feet will occur in many people, particularly in diabetics. As ironic as it may seem, using capsaicin creams may actually alleviate this burning. “In various studies, diabetics who treated their burning feet with capsaicin got greater improvement and we re able to walk more easily than those not using the cream.”45 In addition, using topical applications of capsaicin as opposed to strong, oral drugs is much more preferable.

    ARTHRITIS PAIN

    Clinical tests have confirmed that topical capsaicin ointments substantially alleviate the miserable pain that characterizes osteoand rheumatoid arthritis.46 These studies revealed that using 0.075 capsaicin cream reduced tenderness and pain.47 Dr. Michael T. Murray writes: “ . . . seventy patients with osteoarthritis and thirty - one with rheumatoid arthritis received capsaicin or placebo for 4 weeks. The patients were instructed to apply 0.025 percent capsaicin cream or its placebo to painful knees four times daily. Significantly more relief of pain was reported by the capsaicin-treated patients than by the placebo patients throughout the study . . .”48 Anyone suffering from osteo or rheumatoid arthritis should evaluate the effectiveness of capsaicin ointments for joint pain. Ester Lipstein-Kresch, M.D., has studied the effectiveness of capsaicin creams for arthritis and has stated: “You need to apply it three or four times a day on the affected area for at least two weeks before you’ll see any improvement. An initial burning sensation at the site is not unusual for the first few days, but this goes away with continued application.”49 Note: Capsaicin is also useful for tennis elbow due to its ability to block the transmission of pain.

    MIGRAINE HEADACHES (CLUSTER TYPE)

    Topical applications of capsaicin ointments intranasally may also help to relieve the pain of a specific kind of migraine headache called cluster headaches. Cluster headaches are characterized by s e ve re pain which typically radiates around one eye. The term “cluster” refers to the fact that these headaches tend to occur in clusters of one to three per day and can recur at intervals. Headache pain and severity we re reducing in groups using intranasal capsaicin.5 0 This type of capsaicin treatment should be done under a physician’s care. There is some speculation that capsaicin may be more effective in pre venting migraines before they develop into a full blown attack.51

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    Introduction
    TopPreviousNext

    Date: June 22, 2005 09:40 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Introduction

    Introduction

    Next time someone you know puts a burger on a charcoal grill, notice how the fat drops, sizzling, onto the briquettes beneath. As the drippings burn, the chemical content changes. This really is what burning is, a chemical change from a complex form of the substance to a more simple form. As it changes, many chemicals emerge—some harmless, others less so. One of those chemicals, benzopyrene, can cause mutation of bacteria in the test tube, and that led some scientists to believe it might cause cancer.1 Benzopyrene becomes part of the smoke that rises from the charcoal to settle back on the surface of a cooking burger. This was known as far back as the 1970s, and, for those interested in good health, it became another reason to cut meats from the diet and replace them with healthy grains and vegetable products. Many left it at that. Thankfully, scientists began digging more deeply into this phenomenon, measuring other chemicals and other methods of cooking. One such scientist was Michael Pariza. In 1978, Pariza studied heterocyclic amines to see if they were “mutagenic,” that is, if they would cause bacteria to mutate in the test tube. He found that burgers can be quite safely cooked with care.2 But what changed the direction of his research was an entirely original discovery, separate from what his paper set out to find. This discovery has shaped his career since and may well, in the years to come, help thousands, indeed millions, of people improve their health. What he discovered was that something in hamburger has a “mutagenic inhibitory” effect. That is, something in meat seemed to counteract the bad effects of these mutagens, indeed was an anti-mutagen. In his research, Pariza used a popular scientific test called the Ames Test, named for a scientist at the University of California at Berkeley. This test is still used today for its simplicity by numerous scientists. The test requires enzymes form rat livers stimulated with certain chemicals. Scientists put these enzymes and the possible mutagen onto bacteria. They observe the bacteria in a microscope to see if they have mutated. Pariza changed the experiment slightly. Instead of stimulating rat livers, he used enzymes from normal rat livers. The results showed this anti-mutagenic effect, but just what substance caused it was still a question. For nearly another decade, Pariza and others tried to isolate this substance. Finally, they managed to do so in 1987.3 Call it a previously undiscovered nutrient, one, by the best research now available, that seems essentially vital for optimal health. The substance is CLA— conjugated linoleic acid. Laboratory studies using animals show:

  • • CLA has powerful anti-cancer potential.
  • • It seems to help keep arteries from getting clogged as easily.
  • • It helps a body deal with the cascade of effects that occurs when an infection sets in, helping animals, and potentially humans.
  • • It can help cut body fat while building lean muscle tissue, and that means animals are healthier and, perhaps, lose weight.
  • • Though this question is debated, many researchers believe it is a powerful antioxidant as well. Significantly, because of modern agricultural techniques, the amount of CLA in our diets today is much lower than it used to be, and that may, at least in part, explain America’s growing girth.

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    Anti-Aging Nutrients
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    Date: June 18, 2005 09:07 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Anti-Aging Nutrients

    Anti-Aging Nutrients by Edward C. Wallace, DC, ND Energy Times, February 3, 2000

    What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful, easy feeling.

    How Do We Age?

    Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

    The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

    Programmed Cell Theory

    In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

    Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

    Free Radical/Oxidative Stress Theory

    The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain. On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents.

    Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution. Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

    DNA Repair Theory

    Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

    What Can We Do?

    The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

    In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

    Antioxidant Protection

    Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

    Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.) Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

    In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725). Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

    Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

    Nutrition Deficiencies

    A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

    When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

    A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

    Longevity Diets

    A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460).

    Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers (Epidemiology 3[5], 1992: 389-391).

    Staying Alive

    Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

    Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

    In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

    Longevity and Exercise

    Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

    Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184). In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

    The Treadmill of Life

    The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying (JAMA 273 [14], April 12, 1995: 1093-1098).

    Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

    Longevity Supplementation

    Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging. Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

    Toning Down Enzymes

    Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls. In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

    In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

    The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

    Vitamins E & C

    A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

    Chronological Age Vs.Biological Age

    Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems.

    In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

    Similar Relationship

    A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less.

    And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

    The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

    Carotenoids

    When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

    Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119[1], Jan. 1989: 112-115).

    Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

    Flavonoids

    Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs. For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

    Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

    Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

    Amino Acid Health

    Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68). As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

    Attitude & Behavior

    Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit. In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

    In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

    Longevity at Last

    While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of longer life. And by staying healthier, your old age will be more enjoyable, too.



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    Vitanet ®

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    Botanical Arsenal - Plants can help our bodies fight off cancer's deadly ...
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    Date: June 13, 2005 10:31 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Botanical Arsenal - Plants can help our bodies fight off cancer's deadly ...

    Botanical Arsenal by Fred Thomas Energy Times, May 3, 1999

    The complexities surrounding the various types of cancer stem from the variety of ways in which these diseases can wreak their havoc. Luckily, the equally complex world of plants contains novel compounds that can help our bodies fight off cancer's deadly progress.

    Research Expands

    Research into these botanical compounds is mushrooming. An example: The mighty maitake, a fungus with flair, alternately known as the king (it can grow as large as a basketball, worth its weight in silver to the ancient Japanese); the prince; the Hen of the Woods (it sticks out of from trees when it grows in the wild); and the dancing mushroom to those who leaped for joy when they found one growing in its native northeastern Japan.

    Researchers today dub it with a new moniker: Herbal Heavyweight.

    Mushroom with Potential

    The maitake, with such other medicinal mushrooms as shiitake and reishi, historically has been eaten to promote general well-being and vitality. In the modern lab, however, scientists focus on the potent immune enhancing powers of maitake, which spotlight its cancer fighting potential.

    Twenty years ago, maitake, Grifola frondosa, was an obscure, largely unavailable mushroom. A series of significant Japanese studies then catapulted it into prominence-and popularity.

    Maitake Magic

    Hiroaki Nanba, PhD, of the department of immunology at Kobe Women's College of Pharmacy on Kobe, Japan, and a leading international researcher on maitake, conducted the preliminary tests on the mushroom, demonstrating that it stimulates immune function and inhibits tumor growth.

    In 1986, Dr. Nanba fed powdered maitake to mice injected with tumor cells; 86.3% displayed inhibited tumor growth.

    Dr. Nanba and his colleagues went on to run additional mouse tests, finally reporting that this potent mushroom "directly activates various effector cells (macrophages, natural killer cells, killer T-cells, etc.) to attack tumor cells."

    From then, maitake mushrooms were headed to fame as cancer ninjas.

    Stoking The Immune Engine

    Like other mushrooms, maitake is rich in complex polysaccharides, immunomodulators that successive tests after Dr. Nanba's have shown to be effective in cancer and AIDS treatment.

    The polysaccharides in maitake have a unique structure, rendering them some of the most powerful to be studied (Chem Pharm Bull 1987:35:1162-8).

    What makes maitake a particularly hot property is beta-D-glucan, its primary polysaccharide. Studies show that the body absorbs it readily, at which point it effectively stimulates interleukin-1, natural killer cells and macrophages, anti-tumor warriors that battle solid cancers (Chemotherapy 1990;38:790-6; also International Conference on AIDS, Amsterdam, 1992).

    Effective And Safe

    In addition to lab tests, trials on people have shown that maitake may offer powerful therapy against liver and stomach cancer (studies in China), breast and colon cancer (US research) and Kaposi's Sarcoma, the virulent cancer attacking AIDS sufferers.

    Importantly, studies show that no side effects or interactions accompany maitake's efficacy.

    Maitake fortunately has won the interest and enthusiasm of the scientific community. Currently, researchers at the Cancer Treatment Centers of America, headed by Denis Miller, MD, are completing an exhaustive test of the anticancer and immunostimulatory actions of maitake on folks with advanced colorectal cancer. These investigators hypothesize that the polysaccharide beta-glucans derived from the fruitbody of maitake fight tumors and boost immune function. "Though it cannot be said that maitake ...[is] the cancer cure," said Dr. Nanba in his closing remarks at the Adjuvant Nutrition in Cancer Treatment Symposium in Tampa, Florida, in October 1995, "one can safely say that they do maintain the quality of life of patients and improve the immune system, resulting in the possible remission of cancer cells with no side effects."

    More Bodily Benefits

    Maitake maven Dr. Nanba also has tested-with strongly positive results-the effect of maitake on blood glucose, insulin and triglycerides in mice, whose levels of all three substances declined when they were fed the mushroom (H. Nanba working paper, Anti-Diabetic Activity by Maitake Mushroom, 1994).

    With colleagues, Dr. Nanba showed that maitake lowered blood pressure in hypertensive rats (Chem. Phann. Bu//36:1000-1006,1988). Other studies suggest it may accelerate weight loss.

    This admirable adaptogen (meaning it helps the body adapt to stress and normalize its functions) is water soluble and may be eaten in food or taken as a supplement. Vitamin C is believed to intensify maitake's beta-glucans and enhance their absorption.

    Tea Time

    It's not just what you eat that may help protect against cancer, but what you drink as well. Research from China and Japan, where tea is the everyday drink and rates of several cancers like breast and prostate are lower, may persuade you to turn over a new leaf in your own beverage choice. One of the first studies to spark interest in tea came from Shanghai (Journal of the National Cancer Institute, June 1, 1994), where people who drank two to three cups a day were found to have about a 60% reduction in the risk of cancer of the esophagus. The reason: tea leaves contain compounds called polyphenols, potent antioxidants.

    In fact, in tests at the University of Kansas, three of these, known as catechins, far outshone the common antioxidant vitamins C and E. Clinical trials are just starting, but early results are encouraging. A team of Chinese scientists reported that in a third of people with precancerous mouth sores who drank three cups of a mixture of green and black tea the lesions shrank significantly.

    Researchers at the Saitama Cancer Center in Japan found that green tea seems to improve the prognosis of breast cancer. They followed a group of women with early-stage tumors for seven years. Those who drank more than five cups of green tea a day were only half as likely to suffer a recurrence as patients who consumed fewer than four cups a day.

    Lung Help

    And at the University of Indiana, toxicologist James Klaunig found that the lungs of cigarette smokers who drank the equivalent of six cups of tea a day suffered 40 to 50 percent less damage from the toxins in smoke, potentially lowering their risk of lung cancer and other pulmonary problems. Simultaneously, research from Purdue University suggests tea's cancer-discouraging powers go beyond being an antioxidant. Scientists Dorothy and D. James Morre showed that a tea catechin dubbed EGCG inhibits a growth-promoting enzyme on the surface of many cancer cells-happily without affecting normal cells. And researchers at the Ohio State University College of Medicine found that EGCG counteracted another enzyme, urokinase, that helps cancer cells spread. To top it off, Mayo Clinic scientists recently showed that EGCG prompted prostate cancer cells to commit suicide (Cancer Letters, Aug. 14, 1998).

    Tea Research

    So far, most tea research has focused on green tea, and investigators agree it's more potent than the black tea most Americans favor. But because both kinds come from the same plant, Camellia sinensis (it's the processing that makes the difference as black tea is fermented, green tea isn't) both contain cancer-fighting polyphenols, just in different quantities. As long as the tea you drink (even decaffeinated) is fresh brewed, it's likely to provide some benefit; powdered and prepared teas probably don't. And adding milk may dilute the effect.

    Astragalus Against Tumors

    Astragalus, an herb commonly used in Asia to boost stamina, has impressed western doctors for its potential for helping people cope with chemotherapy. As John Diamon, MD, W. Lee Cowden, MD and Burton Goldberg point out in the Definitive Guide to Cancer (Future Medicine), "Astragalus appears to protect the liver against the harmful toxic effects of chemotherapy and may be effective in treating terminally ill liver cancer patients." (They cite a study in the Jrnl of Ethnopharmacology 1990, 30:145-149.) In addition, they point out, research in Japan supports using a ginseng-astragalus combination to improve the function of natural killer (NK) cells which can boost immunity (Japanese Jrnl of Allergy, 37:2, 1998, 107-114).

    Other studies confirm astragalus' potential in fighting off cancer. Research at the General Hospital of PLA, Beijing, showed that flavonoids (pigments) in astragalus could help protect cell membranes from oxidative damage caused by ultraviolet exposure (Chung Kuo Chung Yao Tsa Chih, 21(12):746-8; 1996 Dec).

    A study of laboratory animals at Cunma University in Maebashi, Japan, found that Astragalus could help preserve immune function against the harmful side effects of chemotherapy (Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 15(2):101-3, 1995 Feb).

    Garlic Benefits

    Like a flame attracting moths, garlic bulbs have irresistibly drawn the attention of medical researchers. A study at Aarhus University, Denmark, found that skin cells in laboratory dishes treated with garlic supplements lived longer, healthier lives than untreated cells (Jrnl Ethnopharm, 1994. 43:125-133).

    Meanwhile, a long list of research demonstrates that garlic's phytochemicals may fight tumors and reduce the carcinogenicity of the pollutants and chemicals that assault us daily. A study in China reported in the American Journal of Chinese Medicine showed that garlic helped slow tumors in lab animals (1983, 11:69-73). Another study in the Journal of Nutrition found that compounds in garlic could "suppress the growth of human colon tumor cells" (126, 1355-1361).

    Added to those benefits, Robert A. Nagourney, MD, reports in the Journal of Medicinal Food (1:1, 1998, 13-28), garlic may "modify the carcinogenicity of foodstuffs." In other words, studies show that garlic can make chemicals in foods like pork less likely to cause your cells to become cancerous. (Ind J Physiol Pharmacol, 39:347-353).

    DNA Protection

    DNA, the stuff that genes are made of, face constant threats from free radicals, caustic molecules that can alter cellular structure and possibly cause genetic mutations that lead to cancer. But research into what are called oligomeric proanthocyanidins (OPC), flavonoids (pigments) derived from fruits vegetables, grape seed extract and the bark of maritime pine trees shows that OPC may be able to shield DNA from injury.

    In particular, studies of a grape seed extract called Activin have demonstrated this substance can help liver cell DNA escape a destructive process called peroxidation (FASEB, 11:3, 2/28/97).

    In these experiments, Activin demonstrated the ability to inhibit the growth of tumor cells as well as slow the replication enzymes of HIV viruses. This protective ability proved to be more potent than that of vitamin C, beta carotene and vitamin E.

    Future Promise

    What does the future promise to reveal? Scientists believe that many unexamined plants probably contain undiscovered phytochemicals that hold great potential for helping us fight the cancer epidemic.

    Certainly, if the next few years produce as many results as the past decade, the next millennium will witness a long line of cancer-prevention discoveries. Before long, you should be able to take advantage of these potent substances.

    As you gulp your garlic, tip your tea cup, mull your maitake, acquire Activin and await your astragalus, you may meditate on what may soon be added to our growing anti-cancer arsenal. Undoubtedly, scientists with a botanical bent will be uncovering more coveted anti-cancer secrets before too long.



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    Vitanet ®

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    Cancer at the Millenium - the war on cancer entering its third decade...
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    Date: June 13, 2005 10:23 AM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Cancer at the Millenium - the war on cancer entering its third decade...

    Cancer at the Millenium by Harriet Brown Energy Times, May 1, 1999

    With the war on cancer entering its third decade, the necessity grows clearer for medical science to engage the enemy on several fronts. Until recently, high-tech medical weapons like vaccines and gene therapy, inspired by a flood of insights into the molecular basis of cancer, garnered most of the hope, hype, headlines and research money. The science was sexy and the prospect of a "cure" dramatic. But, today, advocates of prevention receive equal, if not greater, attention.

    Improving our diets and prudently supplementing with vitamins and minerals, can deliver a major preventive impact. Contentious experts concede that at least a third (and probably more) of all cancers can be blamed on a combination of eating too much of the wrong foods and not enough of the right ones.

    The Dietary Difference

    Though cancer can progress rapidly once it leaps past its inception, it develops over many years and in several stages. Beneficial compounds in food and supplements may intervene along a line that runs from initial exposure to carcinogens to the final step into outright malignancy. Nutrients may: - counteract environmental poisons and the toxic byproducts of liver metabolism

  • - neutralize free radicals (which might otherwise cause carcinogenic mutations in DNA)
  • - boost the immune system
  • - inhibit enzymes that drive cell proliferation
  • - halt metastasis (cancerous reproduction)

    The Big Picture The dietary guidelines advocated by the American Cancer Society and the National Cancer Institute (which generally coincide with those of most health organizations) may sound familiar: Eat plenty of fruits and vegetables. Get lots of fiber. Limit fat, especially animal fat. Go easy on meat and avoid the cured variety (they contain nitrites). If you drink alcohol, do it in moderation. Watch your total calories, and your weight. Pretty straightforward stuff.

    Carotenoid Characteristics

    Carotenoids, as their name suggests, are orange and red pigments in fruits and vegetables, most notably carrots and tomatoes, although they're also in everything from sweet potatoes to spinach and brussels sprouts (in the latter their distinctive color is masked by green chlorophyll).

    Lycopene, a carotenoid found primarily in tomatoes, displays double the free radical-fighting activity of beta carotene, the most widely studied carotenoid. Of 72 studies looking at consumption of tomatoes or tomato-based products reviewed in the February 1999 Journal of the National Cancer Institute, almost half showed a significant reduction in one or more of a variety of cancers.

    Research shows that lycopene may be best at lowering a man's risk of prostate cancer. A 1995 Harvard Medical School study (Journal of the National Cancer Institute 1995; 87: 1767-76) queried nearly 48,000 male health-care professionals about their consumption of fruits and vegetables. The only foods that reduced their risk of prostate cancer were, apparently, tomato sauce, tomatoes, pizza (tomato paste). For those who ate ten servings a week, risk dropped 45 percent; with four to seven servings, 20 percent. In animal studies lycopene decreased the number and size of mammary tumors (Eleventh International Symposium on Carotenoids, 1996).

    Tomatoes are one of the richest sources of lycopene. Cooking tomatoes helps by releasing the lycopene from the plant cell walls. Also, the oil in tomato sauce enhances absorption in the stomach. Lycopene is also available in supplements.

    Unreserved Resveratrol

    Wine drinkers rejoiced when resveratrol, a constituent of the skin of red grapes, was found to protect their hearts (by blocking oxidation of LDL cholesterol and discouraging blood clotting). Now they have another reason to toast this potent antioxidant. When researcher John Pezzuto at the University of Illinois at Chicago screened about 1,000 plants for anticancer activity, he came up with one whose active ingredient turned out to be resveratrol. In lab tests it squelched both free radicals and inflammation, two well-known cancer inducers (Science, 6/10/97). In a study with mice, resveratrol reduced the number of skin tumors by up to 98 percent compared to control animals. Because the effective doses were high (Pezzuto estimates a person would have to quaff about five gallons of wine a day to get the equivalent) and because more than a drink or two a day may raise the risk of breast cancer, researchers don't recommend nondrinkers take up wine. But supplements of synthesized resveratrol (as well as grape juice) may help.

    Fat Chance

    Saturated fat is an authentic dietary villain. Aside from clogging arteries, it's a suspected contributor to several cancers, though the evidence is greater for some cancers (prostate) than for others (breast cancer)

    Of the two other main categories of fats, monounsaturated and polyunsaturated, mono seems benign, if not positively protective. For example, in a study of the influence of diet on breast cancer, Greek researchers discovered that women who consumed higher amounts of olive oil (which is mostly mono) were less likely to be afflicted with breast cancer (Journal of the National Cancer Institute 1995: 87; 110-116).

    When it comes to polyunsaturated fats, however, things get complicated. The fat that predominates in corn, sunflower and other vegetable oils, called omega-6, has long been associated with cancer risk in animal experiments. Likewise the type found in margarines, trans fats, which are partially saturated vegetable oils. On the other hand, the omega-3 fats called EPA and DHA, which are found primarily in deep- and cold-water fish like cod, mackerel, and halibut, protect against both heart disease and cancer. In an epidemiological study covering 24 European countries, British researchers established that mortality rates for colon and breast cancers declined as fish and fish oil consumption rose (British Journal of Cancer 1996: 74; 159-64). And Finnish scientists discovered that the breast tissue of women who had breast cancer contained significantly less DHA and EPA than the breasts of healthy women (Nutrition and Cancer 1995: 24; 151-160).

    Experts believe the omega-3s' anticancer effect derives from its ability to tamp down the prostaglandins that stimulate inflammation. Chronic inflammation unleashes a steady stream of free radicals, which can damage DNA and thereby trigger cancer. Omega-3s also help the liver detoxify potentially harmful substances.

    Fortunately for the fish-phobic, nonmarine sources of omega-3 fats include flaxseed and hemp oils.

    Minerals to Lower Cancer Risk

    n Calcium: possibly protective against colon cancer. In a recent trial (New England Journal of Medicine, 1/14/99) researchers gave people with a history of precancerous colon polyps either two 600 mg calcium tablets a day or a placebo for nine months and found fewer polyps. n Selenium: powerful antioxidant and supporter of immunity. Researchers find that cancer rates in various regions is lowered when soil and vegetables contain more selenium

    In a selenium-depleted area in China afflicted with one of the highest incidences of stomach and esophageal cancer mortality in the world, scientists asked different groups to take various combinations of nutrients. After five years they found a significant reduction in the cancer rate among those who had gotten supplements of selenium, vitamin E and beta carotene (Biological Trace Element Research 1985; 7: 21-29). In the U.S. researchers studying the potential effectiveness of selenium supplementation for preventing nonmelanoma skin cancers came up with a surprise. The 200 mcg a day the subjects received for an average of 4.5 years had no impact on skin cancer but did significantly cut the rates of lung, colorectal and prostate cancers (Journal of the American Medical Association, 12/25/96).

    More recently Harvard researchers determined that men with prostate cancer had much lower levels of selenium in their toenails (a measure of consumption) than healthy men (Journal of the National Cancer Institute, 8/119/98).

    Cruciferous Vegetables

    Cruciferous vegetables like broccoli, brussels sprouts, cauliflower and kale, have long been singled out for their association with protection against cancer. In a 1996 survey of 94 population studies and clinical trials focusing on consumption of cruciferous vegetables, 67 percent showed a reduced risk, the strongest link being with lung, stomach, colon and rectal cancers (Cancer Epidemiological Biomarkers 1996; 5: 733-748).

    Scientists at Johns Hopkins showed that sulforaphane, from these plants, stimulates enzymes that help detoxify carcinogens generated in the liver. When they injected rats with a cancer-causing chemical, only 26 percent of the rodents pretreated with sulforaphane developed mammary cancer, compared to 68 percent of controls. Even animals who did come down with cancer had tumors that appeared later and smaller.

    Other researchers have focused on a cruciferous-vegetable compound called indole-3-carbinol, which has proved especially effective against breast cancer cells. Recently, scientists at the University of California at Berkeley found that indole-3-carbinol, rather than acting as an anti-estrogen, (as had been thought), actually stops breast cancer cells by turning off a protein critical to their replication (Jrnal of Bio Chem, 2/13/98). Consequently, when treating certain forms of cancer, some doctors have paired indole-3-carbinol with the chemotherapy drug tamoxifen - which counteracts estrogen - and found that the combination has proven more potent than either separately.

    Fiber

    Several decades ago British physician Denis Burkitt proposed that the low incidence of colon cancer among native peoples in South Africa was attributable to the fact that their diet was rich in fiber. The fiber, it was hypothesized, bulked up the stool, speeding its passage through the bowel and reducing the time carcinogens contact its lining; it also helped neutralize cancer-promoting bile acids.

    This concept has been backed up by numerous studies. Recently, Harvard researchers sprinkled cold water on this idea, finding that an examination of the eating habits of more than 80,000 female nurses, could find no protective effect against colon cancer or precancerous polyps from consuming fiber (NEJM, January 21, 1999). Most experts' take on this apparent refutation: Maybe the "high fiber" intake in this case wasn't high enough, and this is just one study among many.

    Fighting Breast Cancer

    Fiber has also been linked to reduced rates of breast cancer. At first it was thought that if fat was a breast-cancer culprit, fiber might just be a marker for a low-fat diet. But a look at Finland undermined that idea: Finnish women eat both a lot of fat and a lot of fiber, and their breast cancer rate ranks much below that in the U.S., (where we eat gobs of fat and little roughage).

    Fiber helps take estrogen out of circulation as it passes through the liver, while the isoflavones in many high-fiber plants and vegetables are themselves weak estrogens, which compete for slots on breast tissue's estrogen receptors. The special fiber in flaxseed oil called lignans act against estrogen in two ways: by binding its receptors and by inhibiting the enzyme that converts other hormones into estrogen.

    Fiber comes in two basic forms, insoluble (e.g., wheat bran, celery, the skins of fruits and vegetables) and soluble (e.g., oat bran, citrus fruits, beans). Until a few years ago, scientists believed that cancer protection came mainly from insoluble fiber, but that thinking has turned around.

    A soluble fiber called citrus pectin has been shown to halt the tendency of prostate, lung, breast and skin cancers to metastasize, or spread (e.g., Journal of the National Cancer Institute 1995; 87: 3448-353). Typically cancer turns deadly only when it gets into the bloodstream and invades new territory. Modified citrus pectin appears to stop this aggression by preventing cancer cells from attaching to healthy tissue.

    Novel Antioxidant

    While the name inositol hexaphosphate (IP6) sounds like a mouthful, many of us consume mouthfuls of this natural substance every day - in foods like corn, rice, whole-grain cereals, oats and wheat.

    But now scientists have isolated IP-6 and found that this powerful antioxidant can slow the destructive cellular processes that lead to tumors. In a study published in Anti-Cancer Research (Nov/Dec 1998), scientists at the University of Maryland School of Medicine demonstrated that IP-6 could shrink liver tumors in laboratory animals.

    The researchers believe that IP-6 can help prevent cancer and also be useful in lowering the risk of health problems like kidney stones and heart disease. Research like this continues to expand our knowledge of how to lower the risk of cancer. In the next millennium, with more and more information making its way into the media and onto websites, our power and the responsibility to reduce our risk of cancer will continue to grow and offer new possibilities.



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    Vitanet ®

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    Go Green - green foods may be the SWAT team that sets you free...
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    Date: June 12, 2005 05:27 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Go Green - green foods may be the SWAT team that sets you free...

    Go Green by Chrystle Fiedler Energy Times, December 4, 2003

    If you feel like your busy life is holding your health hostage, green foods may be the SWAT team that sets you free. "Green foods are worth a king's ransom as far as your health is concerned," says Betty Kamen, PhD, author of Betty Kamen's 1,001 Health Secrets (Nutrition Encounter). "Green foods capture solar energy, using it to produce chlorophyll, which gives it its distinctive green color. Since we obtain our food by eating these plants or by eating the animals that eat these plants, this process is the source of human life."

    "Green foods are renewal foods," says Ryan Bradley, ND, of the Bastyr Center for Natural Health in Kenmore, Washington. "They help to counteract the nutrient depletion caused by stress and by caffeine intake. They're nutrient dense, grounding, balancing, and soothing in their energetic nature."

    Ideally, your meals should supply you with greens, but "...99.9% of the population doesn't get three to five [daily] servings of leafy green vegetables like kale, collard greens and spinach," says Jordan Rubin, NMD, PhD, CNC, author of Patient Heal Thyself (Freedom Press). Green foods can bridge that gap.

    "Green foods have become popular because it's a convenient way to get your servings," says Dr. Rubin. "You get the equivalent of two large salads with one serving of powdered green food. It's nutrient dense and low calorie so it's a great addition to any diet. It satisfies the brain so you don't feel hungry."

    "Everyone can benefit from green food supplementation," adds Dr. Kamen. "It's a concentrated supplier of everything that's good about vegetables."

    Chlorophyll for Health

    The key ingredient of green foods is chlorophyll, the green blood of plants. The benefits for humans from chlorophyll can be profound. A study of individuals at high risk of developing liver cancer because of their exposure to environmental toxins showed a 55% reduction in noxious compounds when these people supplemented their diets with a semi-synthetic chlorophyll derivative with properties similar to those of chlorophyll (Proc Natl Acad Sci USA 2001 Dec 4; 98(25):14601-6).

    "This research supports the long-standing notion that chlorophyll, and green foods, can play a role in detoxification in the liver, and thus 'cleansing' the blood," says Dr. Bradley. "It's a good addition to any detox protocol. Test tube evidence also suggests that chlorophyll inhibits mutations in human cells."

    Chlorophyll is antimicrobial and anti-inflammatory. It can help fight anemia, improve digestion and elimination, and act as a mild diuretic. It also helps friendly bacteria in the gut reproduce and thereby possibly boost immunity.

    Green, Green Grasses

    Fast-growing plants, such as wheat and barley cereal grasses, contain the most chlorophyll and the deepest green color.

    "Wheat grass was one of the country's first multi-vitamins," says Dr. Rubin, who is also the author of Restoring Your Digestive Health (Twin Streams Health). "Certified organic cereal grasses pull a vast number of nutrients from the soil."

    "The solar-powered factory in the leaves of the young grass plants is almost beyond comprehension," says Dr. Kamen. "Sprouted grains have exceptional nutritive value and high amounts of certain vitamins and minerals."

    Spirulina Time

    The blue-green microalgae spirulina is a chlorophyll powerhouse.

    "Spirulina is high in protein, up to 65%, and the blue pigment of this blue-green algae, phycocyanin, has antioxidant, antiviral and antifungal properties," says Dr. Rubin.

    Like other greens, spirulina can help you cut calories. "When you nourish the body and the brain with nutrient-dense and low-caloric food, it satisfies that impulse to keep eating." Spirulina is also high in B vitamins such as riboflavin, niacin and pantothenic acid, all commonly depleted nutrients. B vitamins are critical players in overall metabolism, and are vital to nerve and adrenal function.

    Spirulina contains the minerals potassium and magnesium, plus iron. "It's been scientifically validated that [spirulina's iron is] comparable to the absorption from an egg," says Dr. Bradley. "It may benefit patients that are anemic. It's also a great choice for vegans who are looking for plant sources of iron."

    In addition, the spirulina compounds called phycocyanins may control inflammation and lower the risk of cancer.

    "Spirulina stimulates the part of the immune system [natural killer cells] responsible for our ability to fight off viruses and survey our tissues internally and detect and kill cancerous tissue," says Dr. Bradley.

    Chlorella Benefits

    Like spirulina, chlorella stimulates your natural killer cells to fight bacteria and viruses, and to strengthen your defenses.

    "Chlorella is the richest food on the planet in chlorophyll," says Dr. Kamen. "It's also high in protein and rich in beta-carotene and minerals.

    "One of the truly amazing facts about chlorella is its ability to oxygenate the blood," Dr. Kamen continues. "If your blood doesn't have enough oxygen, you can become listless and lethargic. Chlorella actually increases your hemoglobin, the oxygen transporter in your blood, so there is more oxygen present. It provides the necessary fuel for making healthy cells, and the result is renewed energy and vitality."

    Both spirulina and chorella also contain omega-6 fatty acids that have anti-inflammatory benefits and can improve the behavior of your blood vessels. In addition, they provide vitamin B12.

    Green Foods from the Sea

    Seaweed and other sea vegetables like kelp offer a green foods bonanza. Seaweed is low in calories but, like spirulina, offers a wealth of nutrients.

    "Most seaweed provides a rich supply of many essential nutrients, including protein, calcium, iodine and zinc," says Bradley Willcox, MD, co-author of The Okinawa Program (Potter). "Iodine is essential to the function of the thyroid gland, which needs it to make hormones that regulate your body's metabolism. Lignans, the cancer-fighting phytoestrogens have been found in high quantities in seaweed, mostly kelp, which could conceivably provide some protection against certain types of cancers."

    Lower rates of breast cancer were reported in Japanese patients eating a diet high in kelp (Nutr Cancer 1983; 4:217-22). Kelp has also been shown to reduce DNA damage induced by several known carcinogens (Mutat Res 1993; 303:63-70).

    Sea greens contain omega-3 fatty acids, fats that boost heart health. "Sea vegetables may prove to be a more sustainable source of omega-3 fatty acids than the dwindling fish populations," says Dr. Bradley.

    To incorporate sea greens into your diet, start by putting them on your lettuce and tomatoes.

    "Sea vegetables can make a great addition to salads," says Dr. Bradley. "They're high in nutrition and add flavor because of the sodium. They also add texture, giving salads more crunch."

    Other ways to green up your diet:

    * "Kelp comes packaged in three-foot-long dried strips and is prepared by cutting the long strips into smaller two- to three-inch strips and boiling them for about ten minutes. You remove the kelp, and then you can use the broth in soups, salads and other dishes. Kelp simmered with vegetables or tofu and served in miso soup is an Okinawan favorite," says Dr. Willcox.

    * Wakame (one of Dr. Willcox's favorites), a type of kelp, has a taste and appearance that may remind Westerners of spinach lasagna.

    * Nori seaweed can be used to wrap sushi and rice balls and also to season salads, soups and noodles.

    "Seaweed tastes great and if used wisely, should not tip you into sodium overload," says Dr. Willcox.

    Go for the Green

    More and more people are realizing and enjoying the benefits of green foods. Dr. Bradley recommends keeping your green foods consumption simple. Add powdered greens, dried tablets and liquids to juice, mix them into smoothies or a protein shake, and sprinkle the powder on salads. Mixed in water, greens can be used as a morning tonic and help replace some of the nutrients like magnesium and B vitamins depleted by coffee and other caffeinated beverages, which act as diuretics.

    "Incorporate a green drink into your diet once or twice a day," says Dr. Bradley. "It's the least expensive (health) insurance policy you can have."



    --
    Vitanet ®

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    Nutrients for Longevity
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    Date: June 10, 2005 09:59 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Nutrients for Longevity

    Nutrients for Longevity by Edward C. Wallace, ND, DC Energy Times, September 1, 1999

    What's the big deal about trying to live longer? As you grow older (and the American population grows older alongside you) you may want to postpone the inevitable. Few wish to hasten "the journey from which no traveler returns." But as we approach that final bon voyage, chances are we desire clear sailing-aging without disability and with a peaceful easy feeling.

    How Do We Age

    Science has long puzzled about what causes the wrinkles, pains and deterioration of aging. In the search for causes, two basic theories have won over the most proponents: The first holds that cells are programmed with biological clocks that predetermine how many times they can reproduce before becoming non-functional. This theory has been largely formulated by the researcher Leonard Hayflick, MD.

    The second basic theory, introduced by Denham Harman, MD, PhD, in the mid 1950s, holds that cells eventually break down due to attack by caustic molecules called free radicals that cause oxidative stress.

    Programmed Cell Theory

    In the early '60s, Dr. Hayflick observed that human fibroblasts (cells from connective tissue) in the laboratory refused to divide more than about 50 times. Dr. Hayflick also found that even if he froze the fibroblasts after 20 divisions, they would remember that they only had 30 divisions left after thawing.

    Fifty cell divisions have been called the "Hayflick limit." Based on this research, scientists theorize that cells maintain a genetic clock that winds down as old age ensues. Many researchers believe the hypothalamus gland is the force behind our aging clocks, signaling the pituitary gland to release hormones that cause aging.

    Free Radical/Oxidative Stress Theory

    The other popular theory of aging pictures the human body as a cellular battlefield where attackers called free radicals damage our cells and tissues, making them age. In this scenario, a process called oxidation is the chief aging villain.

    On a microscopic level, oxidation generally entails molecules or atoms losing electrons. (Gaining electrons is called reduction.) The molecules or atoms that take these electrons are oxidizing agents. Free radicals are substances that can exist with missing electrons, making them readily able to donate or accept electrons and damage structures in cells. As such, they are highly reactive, binding with and destroying important cellular compounds. Most of the free radicals in your body are made during metabolic processes. More are added from the food you eat and environmental pollution.

    Most of these free radicals contain oxygen molecules. As each cell makes energy in little structures called mitochondria, free radicals result. These oxidant by-products can damage DNA, proteins and lipids (fats). Consequently, toxic by-products of lipid peroxidation may cause cancer, inhibit enzyme activity and produce mutations in genetic material that make you age faster.

    DNA Repair Theory

    Free radical damage to DNA can cause cells to mutate or die. Your body makes enzymes that can repair this damage and slow aging. But, over time, the amount of damage overwhelms the body's ability to fix things. As cells grow older, their ability to patch up DNA diminishes and the rate of damage proceeds faster than repair. The result: We age and eventually die.

    What Can We Do

    The free radical theory of aging suggests that taking antioxidants (compounds known to prevent free radical damage) in our food or as supplements may slow aging.

    In the publication Age (18 [51] 1995: 62), it was reported that "aging appears to be caused by free radicals initiated by the mitochondria at an increasing rate with age. Superoxide and hydrogen peroxide radicals formed by the mitochondria during normal metabolism are major risk factors for disease and death after about the age of 28 in developed countries. Antioxidants from the diet lower the production of free radicals without impairing essential reactions to maintain body function."

    Antioxidant Protection

    Common dietary antioxidants include: vitamins E and C, carotenes, sulphur containing amino acids, co-enzyme Q10 and flavonoids (a group of plant compounds or pigments responsible for the color in fruits and flowers). In addition, melatonin, DHEA and the amino acid compound glutathione may also prove of benefit.

    Glutathione along with the enzyme glutathione peroxidase are an essential part of free radical "quenching." (Quenching means changing free radicals into benign substances no longer capable of harm.)

    Deficiencies may suggest a decreased capacity to maintain detoxification and metabolic reactions in which glutathione plays a role, resulting in increased free radical stress and/or lipid peroxidation. Drinking too many alcoholic beverages can result in glutathione deficiency.

    In a study in which 39 healthy men and 130 healthy women between the ages of 20 and 94 were evaluated for glutathione levels, the older subjects had significantly decreased levels (especially in the 60 to 79-year-old group). The authors felt that physical health and longevity were closely related to glutathione levels (Jrnl Lab & Clin Sci 120(5), Nov. 1992: 720-725).

    Poor nutrition and/or deficiencies in essential micronutrients and many prescription medications may contribute significantly to detoxification capacity in an aged individual. All of these circumstances are common in the elderly.

    Eating a poor diet that contains too many processed foods without many fruits and vegetables can compromise your body's ability to detoxify pollutants, toxins and other harmful compounds. That can set off metabolic processes capable of fomenting large increases in free radical stress that can accelerate aging. Unfortunately, even in a country as prosperous as our own, nutrient deficiencies are frequent, especially in older citizens.

    Nutrition Deficiencies

    A study that looked at what elderly people consumed compared their reported intake with the 1989 Recommended Dietary Amount (RDA) and 1980 RDA: One of four people consumed only two-thirds of the RDA for calories and 60% consumed less than two-thirds of the RDA for vitamin D. As for other nutrients, 50% were found to have inadequate zinc levels (less than two-thirds of the RDA), 31% lacked calcium, 27% were short of vitamin B6, 25% didn't get enough magnesium, 7% missed out on folate and 6% ate less than two-thirds of the requirement for vitamin C (Nutrition Reviews (II), September 1995: S9-S15).

    When researchers examine what everyone in the U.S. eats, they find that only 9% of Americans consume the recommended five servings of fruits and/or vegetables per day (Proceedings of the National Academy of Sciences, Sept 1993).

    A diet high in fruits and vegetables is naturally high in antioxidant compounds and is believed to help you live longer. Unfortunately, if you buy your produce in the supermarket, those fruits and vegetables may also be rich in pesticide and herbicide residues (Consumer Reports, March 1999). Obviously, organic produce lacks these residues. But, in any case, research continues to indicate that a diet low in meats and animal fat and high in vegetables protects against antioxidant damage.

    Longevity Diets

    A six-year study of 182 people over age 70 in rural Greek villages found that those following their traditional diet of olive oil, whole grain breads, fresh fruits and vegetables and wine were less likely to die during the study than those who consumed more red meat and saturated fat. The most important foods in lowering the risk of early death included fruits, vegetables, legumes (peas and beans), nuts, dairy products and cereals (BMJ 311, 1995: 1457-1460)

    Another article in Epidemiology highlights the evidence that eating a vegetarian diet increases your chances of living longer. Included in this survey is a recent country-wide study of diet and health in China, showing that the traditional near vegetarian diet of 10% to 15% of calories coming from dietary fat reduced the chances of heart disease, diabetes and many types of cancers. (Epidemiology 3[5], 1992: 389-391).

    Staying Alive

    Staying skinny and limiting what you eat may also increase longevity. Scientific studies have previously shown that being overweight can theoretically curtail your life, increasing the risk of heart disease, diabetes and other life-shortening conditions. Animal studies have also shown that restricting food can slow diseases associated with aging. Researchers believe that cutting calories helps your immune system stay younger by reducing the formation of substances that are called proinflammatory cytokines.

    Specifically reducing your intake of fatty foods may decrease your chance of coming down with autoimmune diseases. Researchers think omega-6 fatty acid vegetable oils (like corn oil) may increase free radical formation and decrease levels of antioxidant enzyme messenger RNA in addition to other effects. (Nutrition Reviews 53[4], 1995: S72-S79). Another study found that cutting calories lowers the levels of oxidative stress and damage, retards age-associated changes and extends maximum life span in mammals (Science 273, July 5, 1996: 59-63).

    In yet another study, it was shown that caloric restriction early in the life of lab animals increased their life span by a whopping 40% (Australian Family Physician 23[7], July 1994: 1297-1305). Today's modern higher-fat, low-fiber diet with substantial sugar consumption represents everything the longevity researchers say you shouldn't eat.

    Longevity and Exercise:

    Exercise may slow aging. When researchers looked at the exercise habits of 17,000 men, average age of 46, they found that those who took part in vigorous activity lived longer.

    Exercise can improve both cardiac and metabolic functions within the body, while also decreasing heart disease risk. Even modest exercise has been shown to improve cholesterol and blood sugar levels (JAMA 273[15], April 19, 1995: 1179-1184).

    In a study of how exercise affects your chances of living longer, 9,773 men underwent preventive medicine examinations on two different occasions. When the researchers looked at who lived longest, they found the highest death rate was in men who were unfit during both physical exams.

    The Treadmill of Life

    The lowest death rate was in the men who worked out and were in good shape. The researchers concluded that for each minute increase in how long a man could keep treading on a treadmill (between the first and second exam) there was a corresponding 7.9% decrease in the risk of dying. (JAMA 273 [14], April 12, 1995: 1093-1098).

    Since exercise can increase oxygen consumption up to 10 times, boosting the rate of production of free radicals, researchers believe that older individuals need more antioxidant nutrients to protect them. In a paper published in Aging Clinical and Experimental Research (1997), researchers stated that if you regularly exercise in your golden years, you should take more antioxidant vitamins to compensate for this risk.

    Longevity Supplementation

    Melatonin is not often thought of as an antioxidant, but, instead, as a sleep aid. Melatonin, however, is an effective and efficient free radical scavenger and may help stave off the effects of aging.

    Melatonin protects against what are called hydroxyl free radicals. Research shows that older people's lack of melatonin may make them more susceptible to oxidative stress. In one study, researchers felt that new therapies aimed at stimulating melatonin synthesis may eventually lead to therapies for the prevention of diseases related to premature aging (Aging and Clinical Experimental Research 7[5], 1995: 338-339). Melatonin was shown to provide antioxidant protection in several ways.

    Toning Down Enzymes

    Melatonin can ease the effects of enzymes that generate free radicals, enhance the production of glutathione peroxidase (an antioxidant) and defuse the caustic action of free radicals that contain hydroxyls.

    In several studies, DHEA supplementation has been shown to potentially revive immune function in older adults (Exp. Opin. Invest. Drugs 4[2], 1995: 147-154).

    In a study of 138 persons older than 85 years compared to 64 persons 20 to 40 years of age, scientists found that the younger people had four times as much DHEA in their bodies.

    The researchers believe that our bodies make less and less DHEA as we get older. The authors of this study raise the possibility that declining DHEA may be partly to blame for our biological clocks running down (New York Academy of Sciences 1994: 543-552).

    Vitamins E & C

    A growing body of research also supports the benefits of taking vitamins E and C to hold off the effects of getting old. Researchers writing in Free Radicals and Aging (1992: 411-418) point out that as you get older your body is home to more and more free radical reactions that may lead to degenerative diseases like heart disease and arthritis. Research has found that in older people with exercise-induced oxidative stress, taking vitamin E every day may significantly fight off free radicals. (To investigate this effect, scientists measured waste products in urine that result from free radical reactions.) Their conclusion: Dietary antioxidants such as vitamin E may be beneficial.

    Chronological Age Vs. Biological Age

    Vitamin C also looks to scientists like a good anti-aging bet. Research in the Journal of Advancement in Medicine, (7[1], Spring 1994: 31-41) showed that folks consuming larger amounts of vitamin C were less likely to experience clinical problems at all ages. Those taking in less than 100 mg of vitamin C per day also suffered the most problems. In this research, individuals over 50 years of age who daily consumed the largest amount of vitamin C were as healthy or healthier than the 40 year olds who were taking the least amount of vitamin C.

    Similar Relationship

    A similar relationship appears to exist for vitamin E and serum cholesterol levels. In a study of 360 physicians and their spouses, researchers found that people in their 50s who consumed more vitamin E had lower cholesterol than those in their 30s who were taking less. And the longevity beat goes on: In a study evaluating environmental tobacco smoke and oxidative stress, researchers divided 103 people into three groups. Researchers blew smoke at 37 of these folks without protection while 30 of them got to breathe tobacco smoke but took antioxidant supplementation. Another 36 of them merely had to read magazines from doctors' offices. The results: After 60 days of supplementation the antioxidant folks had a 62% reduction in evidence of oxidative damage to their DNA. Cholesterol levels dropped and so did antioxidant enzyme activities. The researchers concluded that taking antioxidants provided a modicum of protection against environmental poisons.

    The range of antioxidant nutrients used in this study included: beta-carotene, vitamin C, vitamin E, zinc and selenium as well as copper (Cancer Epidemiol Biomarkers Prev 7, November 1998: 981-988).

    Carotenoids

    When you mention carotene or carotenoids, most people think of the beta carotene that makes carrots orange. But more than 600 carotenoids are present in colorful vegetables and many of these misunderstood substances are more potent antioxidants than beta-carotene.

    Carotenoids have been shown to destroy oxygen free radicals in lipids (fats), help protect our cells from the sun's ultra violet radiation and enhance our natural immune response (J. Nutr 119(1), Jan. 1989: 112-115).

    Some evidence seems to show that how much carotenoids you (and other mammals) have in your cells may be the predominant factor in determining life span (Proc Natl Acad Sci 82 [4], 1985: 798-802). Therefore, a diet rich in carotenoids (leafy green vegetables, carrots, yams, sweet potatoes, squash, citrus fruits and tomatoes) along with supplementation seems to be just what the fountain of youth ordered.

    Flavonoids

    Flavonoids, a group of antioxidant plant pigments, seem to be able to protect specific organs.

    For instance, the flavonoids in milk thistle (Silybum marianum) have been used for ages for liver problems. Bilberry has been found protective for the eye and hawthorn for the heart and circulatory system.

    Numerous studies have shown the many beneficial effects of flavonoids with perhaps the best known being the ability of anthocyanidins in wine and grape seed extract to help protect your blood vessels and capillaries from oxidative damage (Phytotherapy 42, 1986: 11-14; Am J Clin Nutr 61, 1995: 549-54).

    Flavonoids are found in vegetables and such fruits as blackberries, blueberries, cherries and grapes. A diet rich in these foods helps ensure an adequate intake of these important nutrient compounds.

    Amino Acid Health

    Methionine and cysteine are sulphur containing amino acids (protein building blocks), both of which are essential in maintaining levels of glutathione, a substance that plays a major role in quelling free radicals. Studies have found that as we age, the level of these important amino acids in our bodies decreases. (NEJM 312 [1], 1985: 159-68).

    As it has been shown that adding cysteine to the diet of test animals can increase their life expectancy considerably, researchers believe these amino acids can help us live longer too.

    Attitude & Behavior

    Get more sleep! A recent study showed that men who habitually napped were less likely to have a heart attack. The men in this research who regularly napped for at least 30 minutes per day had about a 30% reduction in heart problems while those who napped for a full hour had a 50% reduction compared to non nappers. Naps of longer duration did not seem to increase the benefit.

    In the same research, investigators also found that spending time with a pet or merely contemplating nature could also improve cardiac health. Sensuality, optimism and altruism also appeared to have health benefits (Family Practice News, December 15, 1998: 14-15).

    In another study, this one in American Psychologist, researchers from the University of California found that people who are self-indulgent, pampered and achieve by running roughshod over the competition are less likely to outlive their healthy peers. Being egocentric, impulsive, undependable and tough-minded were predictors of poor physical health and a shorter life. So loosen up and be nice to your fellow humans! (U.C. Davis Magazine, Fall 1995: 14).

    Longevity at Last

    While no one has suggested that taking supplements, eating vegetables or exercising can, as of yet, extend the human life span past the generally recognized limit of about 120 years, researchers believe they can improve your odds of living longer. An added benefit: By staying healthier, your old age won't only be longer, it will be more enjoyable, too.

    And, who knows, if you hang around long enough, taking your nutrients and getting a comfortable amount of consistent exercise, while meditating and refusing to succumb to stress, that magic bullet that will keep you alive for centuries may be discovered. Some day a new antioxidant or other substance may finally prove to provide the elusive fountain of youth. Stay tuned.



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    Vitanet ®

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    Breast Cancer
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    Date: June 10, 2005 09:44 PM
    Author: Darrell Miller (dm@vitanetonline.com)
    Subject: Breast Cancer

    Breast Cancer by Joseph L. Mayo,MD Mary Ann Mayo, MA Energy Times, May 2, 1999

    What do you fear most? Bankruptcy? Floods? Heart disease? If you're like many women, breast cancer stands near the top of that dreaded list.

    But that fear doesn't permeate other cultures the way it does ours.

    A woman like Mariko Mori, for instance, 52 years old, Japanese, worries about intense pressures beginning to burden her toddler grandson. But worry about breast cancer? Hardly.

    In Indiana, Mary Lou Marks, 50, has similar family frets, mulling over her 28-year-old daughter's career choice.

    But on top of that, when Mary Lou tabulates her other worries, she recoils at the thought of breast cancer. She's heard about her lifetime risk: 1 in 8. Meanwhile, Mariko's is merely 1 in 40, according to Bob Arnot's Breast Cancer Prevention Diet (Little, Brown).

    American Problem
    Experts reporting in "Women at High Risk for Breast Cancer: A Primary Care Perspective" (Prim Care Update Ob/Gyns, vol. 5, no. 6, 1998, p. 269) say the risk of developing breast cancer for the average American woman during ages 40 to 59 is 3.9%; by 60 to 79 years of age that rises to 6.9%. A high-risk 40-year-old has a 20% chance of breast cancer in the next 20 years.

    New studies have found the effect of carrying the gene linked to breast cancer, which is responsible for only 5 to 10% of breast cancer incidence, is not as great as first suspected. Earlier estimates that the gene reflects an 80% chance of incurring breast cancer by age 70 has been recalculated to be only 37% (The Lancet, 1998;352:1337-1339).

    Complex Causesbr> Researchers agree: No one factor is solely responsible for breast cancer. Risk depends on many factors, including diet, weight, smoking, alcohol consumption, activity level and, of course, those genes.

    Regardless of their actual chance of getting breast cancer, women worry. Mary Lou faces no factors that would place her in particular jeopardy. But her anxieties about radical therapies and medical expenses paralyze her: She forgets to visit her health care provider and skips her annual mammogram appointments. Mary Lou's daughter, perhaps in reaction to her mother's gripping fears, campaigns ardently for cancer prevention, educating herself and mobilizing against the cumulative effects of known cancer risks. Smart young woman: A malignancy, after all, can take years to develop. A tumor must swell to one billion cells before it is detectable by a mammogram.

    Dietary Benefits
    Of all the tactics for reducing the risk of breast cancer, diet ranks high on the list.

    The soy-rich regimen of Japanese women like Mariko Mori, for example, helps to explain the low breast cancer rates in Asian countries (see box at center of the page).

    Tomatoes, because of their high quotient of the carotenoid lycopene, have been found to protect cells from the corrosive clutches of oxidants that have been linked with cancer in 57 out of 72 studies (The Santa Rosa Press Democrat, February 17, 1999, page A6, reporting on a Harvard Medical School study). For more on tomatoes see page 16.

    But there's no one magic anti-cancer food or diet. Eating to prevent breast cancer requires a balanced menu with fiber, healthy fats, phytoestrogens and antioxidants, all fresh and free of chemical additives.

    Modifying the balance and type of estrogen, the female sex hormone produced by the ovaries, offers an important breast cancer safeguard. Fat cells, adrenal glands and, before menopause, the ovaries, produce three "flavors" of estrogen, the strongest of which, estradiol, is believed to be carcinogenic when too plentiful or persistent in the body.

    Estrogen does its work by attaching to estrogen receptors. Receptors are particularly numerous in the epithelial cells that line milk sacs and ducts in the breasts.

    A receptor site is like a designated parking spot: Once estrogen is parked there it triggers one of its 400 functions in the body, from preparation of the uterus for pregnancy to intensifying nerve synapses in the brain.

    The food we eat can be a source of estrogen; plant estrogens, called phytoestrogens, are much weaker than the body's estrogens, but they fit the same receptors. Phytoestrogens exert a milder estrogenic effect than bodily estrogen and are capable of blocking the more potent, damaging versions.

    Finding Phytoestrogens
    Foods high in phytoestrogens include vegetables, soy, flaxseed and herbs such as black cohosh, chasteberry, red clover and turmeric. Soy is the darling of the day for good reason. Both soy and flaxseed can lengthen periods, reducing the body's overall exposure to estrogen.

    Soy also contains genistein, an "isoflavone" very similar in molecular form to estrogen but only 1/100,000 as potent. Because of its structure, genistein can attach to cells just as estrogen does; it also helps build carriers needed for binding estrogen and removing it from the body (Journal of Nutrition 125, no.3 [1995]:757S-770S). It acts as an antioxidant to counteract free radicals.

    Tumor Inhibition
    Studies have demonstrated that genistein inhibits angiogenesis (new tumor growth), slowing the progression of existing cancer.

    Soy is most protective for younger women. Postmenopausal women benefit from soy's ability to diminish hot flashes and for cardiovascular protection, especially in combination with vitamin E, fiber and carotene (Contemporary OB/GYN, September 1998, p57-58).

    Experts don't know that much about the cumulative effect of combining hormone replacement with soy, herbs and a diet high in phytoestrogens. Menopausal women who boost their estrogen this way should work with their health care providers and monitor their hormonal levels every six to 12 months with salivary testing.

    The Vegetable Cart
    Some vegetables are particularly protective against breast cancer because they change the way the body processes estrogen. Indol-3-carbinol, found in the co-called cruciferous vegetables such as cauliflower, broccoli and cabbage, diminishes the potency of estrogen. (Broccoli also contains isothiocyanates that trigger anti-carcinogenic enzymes.) These vegetables supply fiber, beta-carotene, vitamin C as well as other vitamins and minerals (Proc of the National Academy of Science USA, 89:2399-2403, 1992).

    Fiber from fruits, vegetables and whole grains reduces insulin levels and suppresses the appetite by making make us feel full, thus helping with weight control, so important to resisting cancer. Fiber also helps build estrogen carriers that keep unbound estrogen from being recirculated and reattached to the breast receptors.

    Cellulose, the fruit and vegetable fiber most binding with estrogen, also rounds up free radicals that damage DNA within cells.,p> Feeding the Immune System Despite heightened public awareness and efforts to stick to wholesome, healthful diets, experts increasingly link poor nutrition to depressed immune systems. Many Americans are at least marginally deficient in trace elements and vitamins despite their best attempts to eat well; that's why a good multivitamin/mineral is wise, even mandatory. Vitamins given to people undergoing cancer treatment stimulate greater response, fewer side effects, and increased survival (International Journal of Integrative Medicine, vol. 1, no. 1, January/February 1999).

    Nutrients tend to work synergistically on the immune system. They should be taken in balanced proportions, and in consultation with your health care provider.

    Immune Boosters
    In Research links low levels of calcium and vitamin D, an inhibitor of cell division and growth, to higher breast cancer rates.

    n Riboflavin (B2), pyridoxine (B6), pantothenic acid (B5), zinc and folate strengthen immunity. Selenium, in lab culture and animal studies, has helped kill tumors and protect normal tissues.

    n Beta-carotene and vitamins A, E and C are antioxidants. Vitamin C enhances vitamin E's effects, boosting immunity and protecting against cell damage. The antioxidant isoflavones in green tea, with soy, convey the anticancer effects of the Asian diet. Research shows actions that discourage tumors and gene mutations.

    The food you eat influences hormones. Excess sugar raises insulin, which acts as a growth factor for cancer and interferes with vitamin C's stimulation of white blood cells. It may contribute to obesity.

    Alcohol is converted to acetaldehyde, which causes cancer in laboratory animals. It affects gene regulation by decreasing the body's ability to use folic acid. It increases estrogen and the amount of free estradiol in the blood. The liver damage that accompanies high alcohol consumption frequently reduces its capacity to filter carcinogenic products, regulate hormones and break down estrogen. Studies of alcohol consumption have caused experts to estimate that drinking more than two alcoholic beverages a day increases breast cancer risk by 63% (OB-GYN News, November 1, 1998, p. 12).

    Fat Can be Phat
    Fat conveys nutritional benefits. Not all fats are bad: we can't survive for very long without certain fats. Fat can turn you into a "well-oiled" machine. But the wrong kind of fat (the fatty acids in red meats and fatty poultry) is believed to be a major culprit in breast cancer.

    Fat cells produce estrogen. Excess fat stores carcinogens and limits carriers that can move estrogen out of your system.

    Once estrogen has attached itself to a receptor, the health result depends on the type of fat in the breast. Saturated fat, transfatty acids and omega-6 fat from polyunsaturated vegetable oils such as safflower oil, peanut, soybean oil, corn oil and in margarine can increase the estrogen effect and trigger a powerful signal to the breast cell to replicate.

    Restraining Prostaglandins
    Blood rich in the essential fatty acids omega-3 and omega-9 lowers cancer risk by driving down levels of prostaglandins, which promote tumor growth. The blood and tumors of women with breast cancer usually contain high levels of prostaglandins.

    Breast tissue is protected by omega-3 fat chiefly from fish and flaxseed and by omega-9 from olive oil. Salmon once a week or water packed tuna three times a week are particularly beneficial. Fish oil supplements processed to reduce contaminates are available. Cod liver oil isn't recommended: its vitamin A and D levels are too high.

    Flaxseed is the richest known plant source of omega-3. Use a coffee grinder to benefit from the seed and oil for the full estrogen effect; sprinkle ground flaxseed over cereal or fold into baked goods. Drizzle flaxseed oil, found in the refrigerator section of your health food store, over salads or cereal. (Store the oil in the refrigerator.)

    Olive oil, especially in the context of the so-called Mediterranean diet of vegetables, omega-3-rich fish and fresh fruit (Menopause Management, January-February 1999, p. 16-19), lowers the risk of breast cancer (The Lancet, May 18, 1996;347:1351-1356).

    Selecting Organic Food
    Select organic foods for extra anticancer protection. Pesticides stimulate erratic cell action and often inhibit the estrogen carrier's ability to attach and remove estrogen from the body. Free floating estrogen then can attach to breast receptors and cause trouble.

    Buy or grow fresh, organic foods whenever you can. When grilling meat, fish or poultry, reduce the area where carcinogens may accumulate by trimming fat. Charred, well-done meat is known to be carcinogenic. When grilling, marinate meat first and reduce the cooking time on the grill by slightly precooking.

    Cancer prevention is an interlocking puzzle requiring the limitation of fat consumption, weight control, exercise, stress reduction and care for psychological and spiritual balance. Possessing more cancer fighting pieces makes you more likely to be able to complete the prevention picture.

    Joseph L. Mayo, MD, FACOG and Mary Ann Mayo, MA, are the authors of The Menopause manager: A Safe Path for a Natural Change, an individualized program for managing menopause. The book's advice, in easy-to-understand portions, isolates in-depth explanations with unbiased reviews of conventional and alternative choices. A unique perspective for mid-life women who want to know all their options.

    Also from the Mayos - The HOW Health Opportunities For Women quarterly newsletter to help women learn HOW to make informed health choices. Learn HOW to: - Choose nutritional supplements

  • - Integrate natural remedies with conventional medicine.
  • - Pick healthier foods.
  • - Reduce breast cancer, osteoporosis and heart disease risk.
  • - Slow aging's effects. Protect against environmental toxins.



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