When antibiotics are necessary, they are crucial to quelling bacterial infections. However, if you or your children suffer colds or flus, diseases caused by viruses, antibiotics have no effect on your illness but could increase your chance of developing allergies.

" Over the past four decades there has been an explosive increase in allergy and asthma in westernized countries, which correlates with widespread use of antibiotics and alterations in gastrointestinal (GI) microflora," says Mairi Noverr, a researcher on a study linking allergies to antibiotic use (104th Gen Meet Amer Soc Microbiol, 2004). "We propose that the link between antibiotic use and dysregulated pulmonary immunity is through antibiotic-induced long-term alterations in the bacterial and fungal GI microflora." While a lot of research needs to be done, it may help to fortify the probiotic, or good, microbes in your intestines with probiotic supplements. One study has shown that giving probiotics to pregnant women helped their children avoid allergic eczema, a skin condition (Lancet 2001; 357:1076-9).

Green Tea Relief

Research has demonstrated that various types of tea can produce a range of health benefits. Tea drinkers can add allergy relief to that list.

Research in Japan demonstrates that for the allergy-oppressed, green tea may help them have nothing to sneeze at. In laboratory tests, scientist found that green tea contains a substance that blocks one of the immune cell receptors which is often a part of the allergic response. The substance, methylated epigallocatechin gallate (EGCG), is believed to have a similar effect in the real world (J Agr Food Chem 10/9/02).

" Green tea appears to be a promising source for effective anti-allergenic agents," notes Hirofumi Tachibana, PhD, the study's chief investigator and an associate professor at Kyushu University in Fukuoka. "If you have allergies, you should consider drinking it." Traditionally, many people have consumed tea as part of their effort to suppress sneezes, coughs and itchy eyes caused by allergies. This experiment supports the evidence that green tea, in particular, has a reliable effect.

According to Dr. Tachibana, green tea's anti-allergenic benefits have not been completely established, but tea apparently has the potential to be effective against allergens like dust, chemicals, pet dander and pollen.

Tea Antioxidant

EGCG has also been shown to be a very active antioxidant, helping to quell the destructive effects of the caustic molecules known as free radicals. Green tea is richer in EGCG than black tea or oolong tea (a type that falls between black and green).

Although other research has demonstrated that EGCG offsets allergic responses in lab animals fed this substance, scientists don't completely understand why it works for allergies. Researchers theorize that EGCG restricts the production of histamine and immunoglobulin E (IgE), two substances secreted in the body as part of the chain of chemical reactions that lead to an allergic reaction, says Dr. Tachibana.

This study shows, for the first time, that a methylated form of EGCG can block the IgE receptor, which is a key receptor involved in an allergic response. The effect was demonstrated using human basophils, which are blood cells that release histamine. As of now, nobody knows how much green tea you need to guzzle to have the best protection against allergies and, of the several varieties available, nobody knows which green tea is best.

Outside of the US, green tea is the second most popular beverage in the world, right behind water. In the US, however, black tea is more popular than green. But the allergy sensitive should think and drink green.

Stay Away from Diesels

Those who are allergic to ragweed or pet dander usually know they should avoid the source of their allergies. But now scientists have found that, for many allergy sufferers, diesel exhaust can also worsen sneezes and wheezes.

Scientists at two southern California schools have shown that about half of us have inherited a sensitivity to diesel pollution that can make our allergies significantly worse (Lancet 1/10/04). "[T]his study suggests a direct way that pollution could be triggering allergies and asthma in a large number of susceptible individuals...," says Frank D. Gilliland, MD, PhD, the study's lead author. Diesel exhaust particles are thought to act as destructive free radicals in the lungs, forming caustic molecules that damage lung tissue. This irritation can cause your immune system to create larger amounts of compounds that make you sneeze and wheeze more.

The Antioxidant Advantage

Antioxidants, scientists believe, can help defuse this damage and ease the body's allergic responses. The California scientists looked at two antioxidant enzymes the body makes to protect the lungs called glutathione S-transferase M1 (GSTM1) and glutathione S-transferase P1 (GSTP1). Only about five of ten people's immune systems can make all the effective forms of these enzymes. The rest of us lack this protection to some degree, and the immune system in about one in five people can't make any effective form of these enzymes.

The research team found that people allergic to ragweed who lacked these antioxidant enzymes suffered more when they took in both ragweed pollen and particles from diesel pollution.

Breathe Easier With C

This research may help explain why many health practitioners recommend vitamin C, a potent antioxidant, to allergy sufferers. Vitamin C "prevents the secretion of histamine by the white blood cells, increases the detoxification of histamine and lowers the blood-histamine levels," says Sylvia Goldfarb, PhD, author of Allergy Relief (Avery/Penguin).

Scientists continue to study the allergy conundrum. Meanwhile, sip a cup of green tea and shut the window before the next truck comes by.

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Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=376)

Date: June 14, 2005 05:56 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Catch Your Breath

Catch Your Breath

by Carl Lowe Energy Times, October 10, 2004

Asthma is on the rise. This serious breathing problem already afflicts 300 million people around the world and is expected to hinder the lung function of 400 million people in 20 years (Annual World Asthma Meeting, 2/17/04).

In the US, asthma continues to strike our kids. According to the US Environmental Protection Agency (2/24/03), the rate at which kids developed asthma doubled between 1980 and 1995. By 2001, 6.3 million American kids had asthma. The cost of treating all these kids: more than $3 billion a year.

Few researchers are prepared to state definitively why asthma rates have continued to climb during the past two decades. However, many investigators point to factors that seem inextricably linked to this disorder, which is marked by wheezing, shortness of breath and coughing spells.

CO2 Buildup

A report from the American Public Health Association and researchers at Harvard puts a lot of the blame for the high rate of asthma on global warming, smog and the atmosphere's growing burden of carbon dioxide. These are linked to industries and car exhaust that release pollution.

In this increasing burden of toxins released into the atmosphere, the rate of asthma among toddlers has grown to be particularly worrisome. Their rate of asthma has climbed more than twice the national average: by 160% between 1980 and 1994. According to these researchers (Inside the Greenhouse: The Impacts of CO2 (Carbon Dioxide) and Climate Change on Public Health in the Inner City), global warming-which involves large increases in atmospheric carbon dioxide released by internal combustion engines and and industrial processes-has fomented the asthma epidemic in several ways:

• Extra heat in the atmosphere has stimulated rapid plant growth that results in more fungus, pollen and spores; this causes allergies that often lead to asthma. Weeds like ragweed, which release allergenic particles, have greatly increased during the past few years. • Extreme weather has caused more floods and damp houses, leading to more indoor air pollution from molds. • Diesel pollutants are now combining with pollen and mold to irritate lungs, causing troublesome allergic reactions.

Bus Fume Hazards

The report notes that in neighborhoods like Harlem, in New York City, 25% of all children suffer asthma. Rates are particularly high in children who live in apartments that are located along bus routes.

A finding that surprised the scientists is the fact that carbon dioxide released by city traffic and the burning of coal and natural gas persists over urban areas, causing a dome of CO2 pollution.

Research on air quality in New York City, Phoenix and Baltimore shows that these lingering CO2 domes contain from 400 parts per million (ppm) of carbon dioxide to 600 ppm. Those levels are significantly above the global average of 379 ppm. Over the course of the earth's history, going back more than 400,000 years before the Industrial Age, research shows the atmosphere has averaged only 180 to 280 ppm.

Nighttime Distress

Breathing difficulties that increase at night can point to asthma, according to Robert Fink, MD: "Asthma can be a nocturnal disease, at its worst between 10 pm and 4 am, when cortisol [a hormone that regulates many bodily functions] levels are lowest" (Pediatric Asthma: Diagnosis and Treatment Goals, Medscape).

Dr. Fink says that if problems with breathing are bad enough to interfere with sleep, a health practitioner should be consulted to analyze the difficulty.

Diet and Asthma

Although nobody can guarantee protection against asthma, research suggests that eating plenty of fruits and vegetables can significantly reduce your risk. For instance, a study in Australia found that people who ate the most apples and pears reduced their chances of suffering from this breath-robbing disorder.

In research involving about 1,600 people, aged 20 to 44, they found that those who consumed the largest quantity of these fruits enjoyed the lowest rate of asthma (AJCN 2003; 78:414).

This is the latest study to confirm the fact that apples and other fruits help to keep lungs healthy. " There is extensive evidence from studies over the last 10 to 15 years that a diet rich in fruits and vegetables is beneficial to lung health," observes Carol Trenga, PhD, a research scientist at the University of Washington in Seattle. "The most compelling evidence is linked to fruits high in vitamin C, which are associated with improved lung function in the general population of adults and children."

Produce for Smokers

Quitting smoking represents one of the best ways to reduce lung disease. But even if you smoke, research on smokers has found that those who ate a moderate amount of fruits and vegetables have fewer lung problems (American Thoracic Society 97th International Conference 5/2001).

And you don't have to change your diet very much to make a difference: In that research, merely eating one and half pieces of fruit a day or eating about a tablespoon of vegetables daily significantly dropped smokers' chances of serious lung disease.

Fruits and Veggies to the Rescue

In a study at the University of Nottingham, United Kingdom, scientists looking at the diets of more than 2,500 people found that eating five or more apples or three tomatoes a week increased lung function. Eating apples and tomatoes also reduced the risk of wheezing.

" The likelihood is that any effect is due to the concerted action of all the nutrients in apples and tomatoes, especially the antioxidants that are particularly rich in the peel of apples and contribute to the coloring of tomatoes," says researcher Sarah Lewis, PhD.

" Antioxidants may work by protecting the airways against the insult of tobacco smoke and other atmospheric pollutants," she adds. Dr. Trenga recommends that everyone eat at least five servings of fruits and vegetables a day. She also notes, "[I]t is reasonable to suggest modest supplementation with for example, vitamin C (250-500 mg twice/day) and vitamin E (up to 400 IU per day), in at-risk populations as a complementary therapy after considering the specific needs of the individual...These levels are very safe and have other health benefits (such as vitamin E and heart disease) in addition to potentially improving lung health."

Herbal Relief

Since asthma is linked to allergies, herbs that help to quell respiratory allergies can possibly lower your risk of asthma. A blend of standardized herbal extracts that contains Phyllanthus emblica (Indian gooseberry or amla), Terminalia chebula (Harda or Haritaki), Terminalia bellerica (bedda nut tree), Albizia lebbeck (Indian walnut), Zingiber officinale (ginger root), Piper longum (Indian long pepper), and Piper nigrum (black pepper) has been found to improve breathing and reduce the effect of allergies (FASEB J 2004; Vol II:A912, Abs. 600.8). Other studies have shown that these herbs can relieve nasal congestion, ease sneezing and clear bothersome mucus (J Am Coll Nutr 22(5): Abs 46, 2003).

Antibiotic Avoidance

Avoiding antibiotics may also lower the risk of asthma. " Over the past four decades there has been an explosive increase in allergy and asthma in westernized countries, says Mairi Noverr, PhD, a researcher who has looked at the lin between antibiotic use with asthma and allergies. " We propose that the link between antibiotic use and dysregulated pulmonary immunity is through antibiotic-induced long term alterations in the bacterial and fungal GI microflora."

In other words, Dr. Noverr's research shows that beneficial bacteria in people's intestines, which take part in strengthening immunity and regulating the immune response to pollen, may have been harmed by the overprescription of antibiotics by physicians. Dr. Noverr and his fellow researchers gave lab animals antibiotics before exposing them to candida albicans (a yeast infection). They then exposed the animals to mold spores. The result: a greater sensitivity to inhaling the spores and breathing problems similar to what people experience during hay fever season (104th General Meeting American Society of Microbiology).

" The studies presented here are the first direct demonstration that antibiotic therapy can promote the development of an allergic airway response," says Dr. Noverr. On a global scale, the outlook for asthma is worrisome. As other countries continue their industrial growth, the burden on the earth's atmosphere will grow. Meanwhile, few serious measures are being taken to reduce global warming, and the national diet frequently neglects lung-friendly vegetables and fruits. But within that uncertain scenario, you can boost your chances of healthy lungs: Eat more apples. Stay away from smoky buses. Hope for clear skies.

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Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=355)

Date: June 13, 2005 10:34 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Clearing the Air

Clearing the Air by Robert Gluck Energy Times, August 1, 1999

One crisp winter morning in Vermont, Alan hoisted his skis over his shoulder and tracked through the dazzling snowpack to the lift about a quarter-mile away. He had trekked this gently uphill route many times and valued it as an invigorating warmup for a day on the ski trails. The path seemed to grow steeper, however, and the winter sun more blazing as Alan struggled for breath, sweat dampening his woolen cap. Weak and wheezing, he paused for what seemed like an eternity and finally turned back, plodding arduously through the ice.

Fit and athletic, the 42-year-old Alan heard the alarming news from his health care practitioner: asthma. The therapy: inhaled steroids.

Breathing Uneasy

The incidence of asthma-a chronic condition characterized by narrowing of the bronchial tubes, swelling of the bronchial tube lining and mucus secretion that can block the airway, making breathing difficult-has ballooned to alarming rates.

In the United States, according to the Centers for Disease Control, the number of people reported to suffer from asthma increased from 10.4 million in 1990 to 15 million in 1995. In 1998, the epidemic cost about $11.3 billion.

Worldwide, experts estimate that the prevalence of asthma increased approximately 50% over the last 10 to 15 years. Nations with the highest rates are the United Kingdom, New Zealand and Australia; lowest are Indonesia, Albania, Romania and Georgia.

Deaths from asthma have doubled in the last decade and, according to the National Institute of Allergy and Infectious Diseases, asthma is the seventh most common chronic health condition in the United States. Children constitute the most disturbingly burgeoning segment of the asthma explosion, its sufferers numbering five to six million. The rate of asthma among children five to 14 years old increased 74% between 1980 and 1994; the rate for preschool kids skyrocketed 160%. Asthma is the number one chronic childhood illness and the third leading cause of hospitalization for children under age 15. More than 5000 Americans die from asthma annually; the fatality rate among children five to 14 years old more than doubled from 1979 to 1995, according to the Asthma and Allergy Foundation.

Waging War on the Wheeze

Asthma is indeed chronic, but it can be prevented and controlled and its effects reversed. Mainstream MDs command an arsenal of pharmaceuticals, some of which are essential for severe or urgent conditions. Consult your health care practitioner about any breathing difficulties.

Because of its complexity, however, asthma requires a balanced therapeutic approach: careful attention to diet, exercise and stress reduction while taking supplemental nutrients and botanicals can help ease asthma's discomforts. Antioxidant nutrients like vitamins C and E, fruits and vegetables rich in phytochemicals plus herbs like echinacea and garlic, all possess the potential for helping the body fight asthma.

Induced by an array of inherent physiological vulnerabilities, some of which may not manifest until adulthood, as well as environmental factors, asthma benefits from extra sleuthing into its causes and planning for relief.

Triggers and Therapies

Asthma is derived from the Greek word meaning panting or breathing hard, which pretty much sums up the malady: Wheezing and shortness of breath typify the attack.

In bronchial asthma, the commonest variety, the passages that carry air from the throat to the lungs narrow as a result of muscle contraction, local inflammation or production of excess mucus. Breathing becomes difficult and wheezy as air is expelled.

"Asthma symptoms are triggered by various factors such as allergens, irritants, infections, pollutants, medications, and emotions," says Anthony Rooklin, author of Living with Asthma: A Comprehensive Guide to Understanding and Controlling Asthma While Enjoying Your Life (Penguin). "Triggers are substances or situations that would be quite harmless to people with ordinary airways, but that bring on asthma symptoms in susceptible individuals."

According to Ellen W. Cutler, nutritionist, enzyme therapist, chiropractor and author of Winning the War Against Asthma & Allergies: A Drug-Free Cure For Asthma and Allergy Sufferers" (Delmar), asthma is an allergic disease that is always triggered by allergens. "These allergens include not only foods, pollens and environmental factors such as perfume, animal dander and chemicals but also bacteria, climactic conditions and emotions," says Cutler.

"When these allergies are active from birth, asthma can be diagnosed early in life, even in infancy," she adds.

Cutler believes every individual with asthma should be able to lead a normal, drug-free life.

"Most asthmatics have been told that asthma is a chronic problem they will have to contend with for the rest of their lives. Asthma can be cured, not miraculously and instantaneously, but inevitably and permanently, once the allergies that cause it have been eliminated," she adds.

Dilating on Nutrients

Although it is vitally important for folks with asthma to develop a treatment plan with a trusted health care provider, that plan, according to experts, may lend itself to a rich variety of complementary options, especially nutrients, phytochemicals, minerals and enzymes.

According to Ruth Winter, author of A Consumer's Guide to Medicines in Food: Nutraceuticals That Help Prevent and Treat Physical and Emotional Illnesses (Crown), researchers in Nottingham, England, linked magnesium and lung function.

"Magnesium is involved in a wide range of biological activities, including some that may protect against the development of asthma and chronic airflow obstruction," Winter says. "Dr. John Britton and his colleagues at Nottingham University measured the magnesium in the diets of 2,633 adults aged 18 to 70 and they found that low magnesium was associated with reduced lung function and wheezing" (The Lancet 344, 1994: 357-62).

Magnesium actually boasts a long history as a bronchial relaxant, first demonstrated in 1912 on cows. Its potential was eclipsed, however, by pharmaceutical antihistamines and bronchodilators until its recent rediscovery.

Defending the Lungs

Antioxidants, with their ability to bolster the lungs' defense mechanisms by battling oxidizing free radicals that constrict bronchial tissue, wield tremendous force in the anti-asthma offensive. Michael T. Murray, ND, and Joseph E. Pizzorno, ND, in their Encyclopedia of Natural Medicine (Prima), connect the steady decrease in dietary intake of antioxidants to the burgeoning incidence of asthma.

Among the top asthma-busting antioxidants:

Vitamin C. Murray and Pizzorno note that C is the major antioxidant present in the lining of the airway and cite generous evidence that when vitamin C is low, asthma incidence is high (Annals Allergy 73, 1994: 89-96). Vitamin C, taken over time, effectively suppresses histamine secretion by white blood cells.

Flavonoids. Also credited with reducing histamine production, flavonoids, notably quercetin and the extracts from grape seed, pine bark and ginkgo biloba, are key asthma-fighting antioxidants (J Allergy Clin Immunol 73, 1984; 769-74).

Carotenes. They limit production of allergy-related compounds (called leukotrienes) and bolster the lining of the respiratory tract (Biochem Biophys Acta 575, 1979: 439-45).

Vitamin E and selenium. Both reduce secretion of leukotrienes (Clinical Exp Allergy 26, 1996: 838-47).

Vitamin B12. Murray and Pizzorno cite the work of Jonathan Wright, MD, whose clinical trials with supplemental vitamin B12 proved strongly effective, especially for children with asthma.

A Bundle of Botanicals

Herbal remedies for asthma date back more than 5000 years to the Chinese emperor Shen-nung. The ancient Egyptians treated respiratory ailments with herbs as well; the Greeks favored mint, garlic, cloves and myrrh for pulmonary problems.

Today, the power of plants has been validated by clinical research and standardized for predictability. (Always consult a health care practitioner when seeking complementary therapies, and read the package labels carefully for dosages and cautions.)

In their book, Asthma: An Alternative Approach (Keats), Ron Roberts and Judy Sammut provide a concise guide to asthma-easing botanicals: Garlic: acts as antiviral, antibacterial and antihistamine; enhances immune response; contains the antioxidant selenium. Garlic also is an expectorant.

Echinacea: a traditional treatment for immune disorders and infections of the upper respiratory tract, known to shorten the duration of colds, coughs and flus.

Ginkgo biloba: inhibits the chemical responses that induce asthma discomfort (Br J Clin Pharmacol 29, 1990: 85-91).

Ginseng: stimulates immunity and the production of steroid-like hormones; helps chronic coughs.

Licorice: an expectorant, anti-inflammatory and anti-allergenic that also inhibits leukotriene production (Acta Med Okayama 37, 1983: 385-91).

Tylophora asthmatica: an Ayurvedic treatment that many respected experts believe can act both as an antihistamine and antispasmodic (Planta Med 57, 1991: 409-13).

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Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=327)

Date: June 13, 2005 10:31 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Botanical Arsenal - Plants can help our bodies fight off cancer's deadly ...

Botanical Arsenal by Fred Thomas Energy Times, May 3, 1999

The complexities surrounding the various types of cancer stem from the variety of ways in which these diseases can wreak their havoc. Luckily, the equally complex world of plants contains novel compounds that can help our bodies fight off cancer's deadly progress.

Research Expands

Research into these botanical compounds is mushrooming. An example: The mighty maitake, a fungus with flair, alternately known as the king (it can grow as large as a basketball, worth its weight in silver to the ancient Japanese); the prince; the Hen of the Woods (it sticks out of from trees when it grows in the wild); and the dancing mushroom to those who leaped for joy when they found one growing in its native northeastern Japan.

Researchers today dub it with a new moniker: Herbal Heavyweight.

Mushroom with Potential

The maitake, with such other medicinal mushrooms as shiitake and reishi, historically has been eaten to promote general well-being and vitality. In the modern lab, however, scientists focus on the potent immune enhancing powers of maitake, which spotlight its cancer fighting potential.

Twenty years ago, maitake, Grifola frondosa, was an obscure, largely unavailable mushroom. A series of significant Japanese studies then catapulted it into prominence-and popularity.

Maitake Magic

Hiroaki Nanba, PhD, of the department of immunology at Kobe Women's College of Pharmacy on Kobe, Japan, and a leading international researcher on maitake, conducted the preliminary tests on the mushroom, demonstrating that it stimulates immune function and inhibits tumor growth.

In 1986, Dr. Nanba fed powdered maitake to mice injected with tumor cells; 86.3% displayed inhibited tumor growth.

Dr. Nanba and his colleagues went on to run additional mouse tests, finally reporting that this potent mushroom "directly activates various effector cells (macrophages, natural killer cells, killer T-cells, etc.) to attack tumor cells."

From then, maitake mushrooms were headed to fame as cancer ninjas.

Stoking The Immune Engine

Like other mushrooms, maitake is rich in complex polysaccharides, immunomodulators that successive tests after Dr. Nanba's have shown to be effective in cancer and AIDS treatment.

The polysaccharides in maitake have a unique structure, rendering them some of the most powerful to be studied (Chem Pharm Bull 1987:35:1162-8).

What makes maitake a particularly hot property is beta-D-glucan, its primary polysaccharide. Studies show that the body absorbs it readily, at which point it effectively stimulates interleukin-1, natural killer cells and macrophages, anti-tumor warriors that battle solid cancers (Chemotherapy 1990;38:790-6; also International Conference on AIDS, Amsterdam, 1992).

Effective And Safe

In addition to lab tests, trials on people have shown that maitake may offer powerful therapy against liver and stomach cancer (studies in China), breast and colon cancer (US research) and Kaposi's Sarcoma, the virulent cancer attacking AIDS sufferers.

Importantly, studies show that no side effects or interactions accompany maitake's efficacy.

Maitake fortunately has won the interest and enthusiasm of the scientific community. Currently, researchers at the Cancer Treatment Centers of America, headed by Denis Miller, MD, are completing an exhaustive test of the anticancer and immunostimulatory actions of maitake on folks with advanced colorectal cancer. These investigators hypothesize that the polysaccharide beta-glucans derived from the fruitbody of maitake fight tumors and boost immune function. "Though it cannot be said that maitake ...[is] the cancer cure," said Dr. Nanba in his closing remarks at the Adjuvant Nutrition in Cancer Treatment Symposium in Tampa, Florida, in October 1995, "one can safely say that they do maintain the quality of life of patients and improve the immune system, resulting in the possible remission of cancer cells with no side effects."

More Bodily Benefits

Maitake maven Dr. Nanba also has tested-with strongly positive results-the effect of maitake on blood glucose, insulin and triglycerides in mice, whose levels of all three substances declined when they were fed the mushroom (H. Nanba working paper, Anti-Diabetic Activity by Maitake Mushroom, 1994).

With colleagues, Dr. Nanba showed that maitake lowered blood pressure in hypertensive rats (Chem. Phann. Bu//36:1000-1006,1988). Other studies suggest it may accelerate weight loss.

This admirable adaptogen (meaning it helps the body adapt to stress and normalize its functions) is water soluble and may be eaten in food or taken as a supplement. Vitamin C is believed to intensify maitake's beta-glucans and enhance their absorption.

Tea Time

It's not just what you eat that may help protect against cancer, but what you drink as well. Research from China and Japan, where tea is the everyday drink and rates of several cancers like breast and prostate are lower, may persuade you to turn over a new leaf in your own beverage choice. One of the first studies to spark interest in tea came from Shanghai (Journal of the National Cancer Institute, June 1, 1994), where people who drank two to three cups a day were found to have about a 60% reduction in the risk of cancer of the esophagus. The reason: tea leaves contain compounds called polyphenols, potent antioxidants.

In fact, in tests at the University of Kansas, three of these, known as catechins, far outshone the common antioxidant vitamins C and E. Clinical trials are just starting, but early results are encouraging. A team of Chinese scientists reported that in a third of people with precancerous mouth sores who drank three cups of a mixture of green and black tea the lesions shrank significantly.

Researchers at the Saitama Cancer Center in Japan found that green tea seems to improve the prognosis of breast cancer. They followed a group of women with early-stage tumors for seven years. Those who drank more than five cups of green tea a day were only half as likely to suffer a recurrence as patients who consumed fewer than four cups a day.

Lung Help

And at the University of Indiana, toxicologist James Klaunig found that the lungs of cigarette smokers who drank the equivalent of six cups of tea a day suffered 40 to 50 percent less damage from the toxins in smoke, potentially lowering their risk of lung cancer and other pulmonary problems. Simultaneously, research from Purdue University suggests tea's cancer-discouraging powers go beyond being an antioxidant. Scientists Dorothy and D. James Morre showed that a tea catechin dubbed EGCG inhibits a growth-promoting enzyme on the surface of many cancer cells-happily without affecting normal cells. And researchers at the Ohio State University College of Medicine found that EGCG counteracted another enzyme, urokinase, that helps cancer cells spread. To top it off, Mayo Clinic scientists recently showed that EGCG prompted prostate cancer cells to commit suicide (Cancer Letters, Aug. 14, 1998).

Tea Research

So far, most tea research has focused on green tea, and investigators agree it's more potent than the black tea most Americans favor. But because both kinds come from the same plant, Camellia sinensis (it's the processing that makes the difference as black tea is fermented, green tea isn't) both contain cancer-fighting polyphenols, just in different quantities. As long as the tea you drink (even decaffeinated) is fresh brewed, it's likely to provide some benefit; powdered and prepared teas probably don't. And adding milk may dilute the effect.

Astragalus Against Tumors

Astragalus, an herb commonly used in Asia to boost stamina, has impressed western doctors for its potential for helping people cope with chemotherapy. As John Diamon, MD, W. Lee Cowden, MD and Burton Goldberg point out in the Definitive Guide to Cancer (Future Medicine), "Astragalus appears to protect the liver against the harmful toxic effects of chemotherapy and may be effective in treating terminally ill liver cancer patients." (They cite a study in the Jrnl of Ethnopharmacology 1990, 30:145-149.) In addition, they point out, research in Japan supports using a ginseng-astragalus combination to improve the function of natural killer (NK) cells which can boost immunity (Japanese Jrnl of Allergy, 37:2, 1998, 107-114).

Other studies confirm astragalus' potential in fighting off cancer. Research at the General Hospital of PLA, Beijing, showed that flavonoids (pigments) in astragalus could help protect cell membranes from oxidative damage caused by ultraviolet exposure (Chung Kuo Chung Yao Tsa Chih, 21(12):746-8; 1996 Dec).

A study of laboratory animals at Cunma University in Maebashi, Japan, found that Astragalus could help preserve immune function against the harmful side effects of chemotherapy (Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, 15(2):101-3, 1995 Feb).

Garlic Benefits

Like a flame attracting moths, garlic bulbs have irresistibly drawn the attention of medical researchers. A study at Aarhus University, Denmark, found that skin cells in laboratory dishes treated with garlic supplements lived longer, healthier lives than untreated cells (Jrnl Ethnopharm, 1994. 43:125-133).

Meanwhile, a long list of research demonstrates that garlic's phytochemicals may fight tumors and reduce the carcinogenicity of the pollutants and chemicals that assault us daily. A study in China reported in the American Journal of Chinese Medicine showed that garlic helped slow tumors in lab animals (1983, 11:69-73). Another study in the Journal of Nutrition found that compounds in garlic could "suppress the growth of human colon tumor cells" (126, 1355-1361).

Added to those benefits, Robert A. Nagourney, MD, reports in the Journal of Medicinal Food (1:1, 1998, 13-28), garlic may "modify the carcinogenicity of foodstuffs." In other words, studies show that garlic can make chemicals in foods like pork less likely to cause your cells to become cancerous. (Ind J Physiol Pharmacol, 39:347-353).

DNA Protection

DNA, the stuff that genes are made of, face constant threats from free radicals, caustic molecules that can alter cellular structure and possibly cause genetic mutations that lead to cancer. But research into what are called oligomeric proanthocyanidins (OPC), flavonoids (pigments) derived from fruits vegetables, grape seed extract and the bark of maritime pine trees shows that OPC may be able to shield DNA from injury.

In particular, studies of a grape seed extract called Activin have demonstrated this substance can help liver cell DNA escape a destructive process called peroxidation (FASEB, 11:3, 2/28/97).

In these experiments, Activin demonstrated the ability to inhibit the growth of tumor cells as well as slow the replication enzymes of HIV viruses. This protective ability proved to be more potent than that of vitamin C, beta carotene and vitamin E.

Future Promise

What does the future promise to reveal? Scientists believe that many unexamined plants probably contain undiscovered phytochemicals that hold great potential for helping us fight the cancer epidemic.

Certainly, if the next few years produce as many results as the past decade, the next millennium will witness a long line of cancer-prevention discoveries. Before long, you should be able to take advantage of these potent substances.

As you gulp your garlic, tip your tea cup, mull your maitake, acquire Activin and await your astragalus, you may meditate on what may soon be added to our growing anti-cancer arsenal. Undoubtedly, scientists with a botanical bent will be uncovering more coveted anti-cancer secrets before too long.

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Vitanet ®

(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=326)

Date: June 10, 2005 09:51 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Immunity - The Big Picture

Immunity: The Big Picture by Brian Amherst Energy Times, August 3, 1999

Your body wants to be well. Outfitted with a battalion of defenses for strategic deployment, your immune system explodes with resistant force at the first sign of infective invasion.

Think of the time a tiny splinter embedded itself in your thumb. By bedtime, the spot rose and reddened; by morning, white blood cells had launched their campaign, building a hot, throbbing fortification. By day's end, the bit of wood was propelled to the surface and ejected by the immune system warriors. Once again, a foreign assailant was summarily ousted.

The Protective Force
The immune system is a dazzlingly complex mechanism charged with guarding against infection, colds, flu and cancer. Laced with networks of couriers and transmitters, backed up by intricate fail safe devices and reinforced by memory units, immunity constantly adapts to highly specific and evolving needs.

"Supporting the immune system is critical to good health. Conversely, good health is critical to supporting the immune system." So write naturopathic doctors Michael T. Murray and Joseph E. Pizzorno in their Encyclopedia of Natural Medicine (Prima).

Maintaining the immune system requires a comprehensive program of wholesome diet, resilient attitude, fitness enhancing activity and nutrients keyed to the clear and specific needs of this energetic machine.

The all-star lineup for immune sustenance: a high-potency multiple vitamin/mineral formula, vitamins C and A, bioflavonoids, isoflavones, zinc and selenium, antioxidants like ActiVin (grape seed extract) and pycnogenol (French maritime pine bark), as well as the botanicals echinacea and astragalus.

But optimal partnering with your immune system also benefits from understanding its workings.

The Battlefronts
The immune system wages war on the organ, tissue and cellular fronts. It encompasses the lymphatic vessels and organs (lymph nodes, thymus, spleen and tonsils), white blood cells, specialized cells in particular tissues and customized chemicals.

Lymph, a milky fluid consisting of water protein and immune cells, is the essence of the immune system. Powered by muscle movement (an important reason why exercise boosts immunity), the lymphatic system collects and transports lymph to the lymph nodes. These nodes contain certain immune cells and filter out invading antigens, as well as produce antibodies, before siphoning the lymph out into the bloodstream.

If you've ever had "swollen glands," that means your lymph nodes have been in overdrive.

Macrophages are the immune cells that filter lymph, consuming bacteria and cellular debris while protecting the lymph system from invasion and damage.

Gland Tidings
Two organs dominate immune function: n The thymus. The most influential, critical gland of the immune system, located just below the thyroid gland and above the heart; produces T lymphocytes, white blood cells responsible for cell-mediated immunity not controlled by antibodies. This immune response is tailored to specific antigens and is vital to resisting infection from mold-like bacteria including yeast, fungi, parasites and such viruses as Epstein-Barr, herpes simplex and hepatitis. It also protects against cancer, allergies and autoimmune disorders like rheumatoid arthritis. n The spleen. The largest mass (about seven ounces) of lymphatic tissue in the body, located in the upper left abdomen behind the lower ribs; it produces white blood cells, which engulf and destroy bacteria and cellular debris; recycles material from worn out red blood cells and platelets; produces immune system enhancing compounds, including the proteins tufsin and splenopentin, and spleen extracts.

The White Blood Cell Album
Although white blood cells (WBCs) are uniformly accountable for protecting the body against bacteria, viruses, fungi and parasites, the different types of WBCs vary considerably in form and function. n Neutrophils phagocytize, that is, eat, viruses, bacteria and old or dead cells. They don't need any biochemical messengers for activation and their effectiveness is wide-ranging.

In Monocytes collect cellular trash after infections and can trigger immune responses; eosinophils can eliminate foreign particles and, with basophils, are involved in immune response.

In Lymphocytes include varieties of T cells, which work with other white blood cells or attack and destroy foreign tissue, cancer cells or virus-infected cells; B cells that produce antibodies that bind to bacteria, viruses or tumors; and natural killer cells (NKCs) that destroy cancerous or virally-infected cells.

(Based on information in the Encyclopedia of Natural Medicine; The Road to Immunity: How to Survive and Thrive in a Toxic World (Pocket Books) by Kenneth Bock, MD, and Nellie Sabin; and the Johns Hopkins Family Health Book (Harper Resource).

Keep the System Sound
Your immunity mechanism calls for special care and support. The dilemma: How to develop a balanced system of complementary and alternative therapies to build and sustain powerhouse immunity? "There is no question that, in terms of immune system response, certain supplements can reduce infections, asthma, autoimmune disease and risk factors for cancer," says Samuel D. Benjamin, MD, former project director of the Arizona Center for Health and Medicine and an ardent advocate for complementary medicine.

"But you must always be sure to maintain the mind-body-spirit link," he told Energy Times. "For the mind, it could be exercise, yoga or meditation. Evidence shows improved immune system responses from these therapies. And in any case, you never read in the headlines that somebody has been admitted to the emergency room overdosing on meditation.

"Intentionality also is an important part of the mind link: believing you are going to fare well. For your spirit, you must ask yourself such questions as, Do I feel connected to others?

"For the body, a daily multivitamin and mineral supplement. Much depends on your community: I live on Long Island, where there is a high incidence of breast cancer, so I would recommend green tea and isoflavones from soy products for women."

Dr. Benjamin stresses moderation in the use of immune-intensifying supplements, among which he cites mixed carotenoids, zinc and vitamin E.

The Soy Solution
Scientists who took the cue from the apparent link between high-soy Asian diets and low cancer incidence have developed a compelling case for soy as an immune-supportive anticancer agent.

In a study conducted by the University of Southern California at Norris and published in the March 4, 1998 Journal of the National Cancer Institute, researchers reported that genistein, an active component of soy products, short-circuits the ability of tumor cells to elude destruction by the immune system due to an excess of defensive stress proteins.

Genistein seems to make cancer cells vulnerable to the immune response. Researchers at Wake Forest University told participants at the January 1999 meeting of the American Association for the Advancement of Science that dietary or supplemental soy fed to monkeys counteracted cell proliferation that is a cancer precursor.

That Championship C
Probably the most widely recognized immune accelerator is vitamin C, an honored warrior against scurvy and, in 1970, again celebrated by Linus Pauling for its preventive powers over the common cold.

Immune cells are known to accumulate and retain high levels of vitamin C. Researchers at Memorial Sloan-Kettering Cancer Center in New York now understand how that happens: Proteins called growth factors (which control growth and production of immune cells) also increase those cells' ability to take up vitamin C.

These researchers, reporting in the April 1998 issue of the journal Blood, explain that the additional glucose that the growth factors pump into immune cells (for enhanced energy), plus extra vitamin C, intensify immune response.

And folks with higher levels of vitamin C in their blood serum experience less cell damage from free radicals that leads to cancer, heart and pulmonary disease and other chronic conditions.

Scientists at the University of Buffalo (addressing the June 13, 1997 meeting of the Society for Epidemiologic Research) deduced from studying population groups that high levels of vitamin C are associated with low oxidative stress and lower risk of cell damage.

From A to Zinc
In Kids with neuroblastoma, a malignant tumor of embryonic nerve cells and the third most common form of childhood cancer, experienced significantly improved survival rates when their therapy included high doses of retinoic acid, a derivative of vitamin A, according to researchers at the University of California, San Francisco, and Childrens Hospital Los Angeles, who reported to the American Society for Clinical Oncology on May 18, 1998.

In Colostrum, the pre-milk liquid produced by mammals during the first 24 to 48 hours after birth, took the spotlight recently as a supplement imbued with multiple immune factors and natural antibiotics that augment body's immune response. A 1992 study showed that bovine colostrum might be able to reduce and prevente infections in immune deficient folks, especially those with AIDS.

In University of Pittsburgh Cancer Institute researchers found for the first time (on laboratory animals) that vitamin D appreciably inhibits widespread prostate cancer by binding to cancer cells and triggering cell death or their transformation to benign cells.

In Vitamin E exerts formidable immune-enhancing influence on both antibody and cell-mediated immunity. One fundamental study in the Journal of the American Medical Association (245, 1981: 53-58) established conclusively that vitamin E deficiency results in significant impairment of immune function. Later studies demonstrated that it reduces prostate cancer by up to one-third.

In Coenzyme A, described as a metabolic enzyme, takes part in starting numerous body processes that provide energy for the immune system. If you ever run short of this enzyme, fat processing within your body would grind to a halt.

in Researchers looking at a substance with the tongue twisting name 3-acetyl-7-oxo-Dehydroepiandro-sterone, believe it aids immunity by quelling stress hormones.

in Mushrooms contain natural substances called polysaccharides, believed to enhance immunity. In particular, maitake mushroom, which conveys the immune booster beta-D-glucans, is reputed to help fight infections and drop blood pressure.

in Men and women taking selenium supplements for 10 years had 41% less total cancer than those taking a dummy, according to a January 1997 study by Cornell University and the University of Arizona. Other studies have shown it to reduce the risk for colon cancer by about 60%. n Zinc may provide immediate protection against the all too common cold. Scientists at the University of Florida were the first to apply genetic fingerprinting methods like those used in criminal and paternity investigations to understand how nutrients directly affect human immune cells.

The study, in the April 1998 Journal of Nutrition, demonstrates that zinc signals cells to make the protein metallothionein, which protects against infections, toxins and other stressors.

Phytochemicals a la Carte
Researchers extol the powers of phytochemicals in fruits and vegetables available in dietary or supplement form as immune-igniting antioxidants. These compounds neutralize free radicals that oxidize cellular membranes, rendering them vulnerable to cancer.The Strang Cancer Prevention Center, an affiliate of New York Presbyterian Hospital, offers a menu of the top antioxidant phytochemicals. The center's director, Mitchell L. Gaynor, MD, is coauthor (with Jerry Hickey, RPh) of Dr. Gaynor's Cancer Prevention Program (Kensington): n Carotenoids, including beta-carotene from veggies and lycopene (the substance that lends the tomato is ruddy complexion), fight free radicals.

n Isoflavones from soy, fight angiogenesis, the process by which new blood vessels form to supply nutrients to cancerous growths. n Sulforaphane in broccoli, kale and cabbage activates anticancer enzymes.

n Omega-3 fatty acids in cold water fish block the synthesis of prostaglandins, natural compounds in the body that promote tumor growth.

n Ginger contains antioxidant compounds, each more potent than vitamin E. Recent studies on mice show ginger can prevent skin tumors. n Rosemary contains carnosol which deactivates carcinogens and helps limit the effects of prostaglandins.

Sometimes the world can look like a dangerous place, especially when you're sick and tired much of the time. But in the search for immunity, menus of health help like this ensure that no matter what your immunity needs, a boost can be yours with the proper nutrient selection.

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Vitanet ®

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Date: June 10, 2005 04:08 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Basic Detox

Basic Detox by Harriet Epstein , February 4, 2002

Basic Detox By Harriet Epstein Trying to stay healthy and clean in a dirty world can prove a difficult task. The rise of modern industry and agriculture has meant the widespread accumulation of toxins in our environment that can cause health problems.

As Kenneth Bock, MD, and Nellie Sabin point out in their book The Road to Immunity (Pocket), "Fat soluble chemicals are readily absorbed by the body but are difficult to excrete. To be excreted, they must first be enzymatically converted into water-soluble substances. Some of them can't be converted at all."

Bock and Sabin point out that a 1990 survey by the United States Environmental Protection Agency (EPA) that looked at people's tissues found that everyone the agency examined had styrene (a chemical used to make plastic) and xylene (a paint and gasoline solvent) stored in their bodyfat.

Toxin Exposure

The toxins that you encounter every day are not only present in air and water, but also may be found in food and medicines. If we eat beef that's been exposed to pesticides, those chemicals may be shunted into our bodyfat. Pesticide residues in fruits and vegetables may end up in a similar place.

To cope with chemicals, the human body has evolved methods for detoxifying. When we breathe out we often release inhaled toxins. Other toxins are purged through urine, feces and sweat.

One of the chief organs responsible for cleansing the body is the liver. This organ utilizes a pair of chemical pathways for breaking down and eliminating toxins. In our hectic, industrialized world, this flow of toxins can overwhelm the liver's ability to detoxify. In addition, the dual processes the liver uses to eliminate noxious substances may become unbalanced, allowing toxins produced by one pathway to build up to dangerous proportions.

Languishing Liver

Once liver function falters, toxic havoc ensues. Toxins may remain in the body, often stored indefinitely in bodyfat. The body's detoxifying systems may be swamped with toxins.

In protecting the liver and enhancing its detox functions, many naturopathic practitioners recommend the herb milk thistle (silybum marianum). According to Steven Bratman, MD, and David Kroll, PhD, authors of the Natural Health Bible (Prima), milk thistle helps the liver cope with its toxic load. Consequently, milk thistle is frequently used in Europe for liver problems like jaundice.

Bratman and Kroll point out that milk thistle "is one of the few herbs that have no real equivalent in the world of conventional medicine." As Lise Alschuler, ND, medical director at the Bastyr Natural Health Clinic, told Natural Digest, "Milk thistle protects the liver against toxic damage (and) helps prevent damage to the rest of the body."

Toxin Zappers

The compounds in milk thistle that help zap toxins, known as silymarin, protect the liver by binding with substances that would otherwise interact with the liver and slow its function. They also help the liver repair itself and regenerate new liver cells.

As an extra bonus, silymarin acts as an antioxidant, protecting liver cell membranes from oxidative damage.

Dandy Detox

Dandelion has a place as another traditional treatment for toning the liver and boosting the body's filtration system. The leaves are a cornucopia of antioxidants and nutrients including B vitamins, vitamins A, C and D, plus boron, silicon, potassium, magnesium and zinc. They help detoxify by acting as a mild diuretic: they cause the body to eliminate excess fluid.

But herbalists worldwide have found the compounds in dandelion root most useful for helping alleviate liver and gall bladder malfunction. (If you think you suffer these difficulties, consult your health practitioner.) Two unique and helpful natural substances found in dandelion root are chemicals called germacranolide and eudesmanolide. The root, according to the Natural Health Bible, has traditionally been used to speed up a sluggish or congested liver as well as detoxing the body by eliminating constipation. Research indicates dandelion root may stimulate bile flow (Arzneimittel -forschung 9, 1959: 376-378).

Juniper berries (Juniperus communis), may also be taken with dandelion as a diuretic. This botanical, often used to combat urinary tract problems, is also an anti-inflammatory (Phyto Res 1, 1997: 28-31).

Metal Problems

Heavy metals rank as dangerous toxins unleashed by modern industry. As Michael Murray, ND, and Joseph Pizzorno, ND, explain in the Encyclopedia of Natural Medicine (Prima), metals like lead, mercury, cadmium, arsenic, nickel and aluminum can "accumulate within the (body) where they can severely disrupt normal function."

Public health experts estimate at least one in five Americans has been a victim of heavy metal poisoning. Lead may be the most common villain. In your everyday life, you may be ingesting metals from your cookware, from pesticides, cigarette smoke, dental fillings, polluted fish, and chipping house paint.

Signs that you may suffer from toxicity linked to heavy metals: Unusual fatigue, Persistent headaches, Unexplained muscle pains, Anemia, Ringing in the ears or dizziness and Tremors.

Of course, if you think you suffer from heavy metal poisoning, you should see a knowledgeable health practitioner as soon as possible. Murray and Pizzorno recommend an array of precautions to protect yourself against heavy metals in the environment:

Take a daily multivitamin and mineral.

Take extra amounts of vitamin C and B-complex.

Take amino acids that contain sulfur (taurine, cysteine and methionine) and high sulfur foods like onions and garlic (or supplements). (Consult your pharmacist of health practitioner before taking individual amino acids.)

Consume water-soluble fibers like guar gum, oat bran, psyllium and pectin.

Smooth Digestion

In addition, Leo Galland, MD, in his book The Four Pillars of Healing (Random House) offers these tips for keeping your digestive tract functioning at top capacity:

Add spices to your foods and consume garlic, onion, turmeric, rosemary and sage to aid digestion.

Take supplements of lactobacil-lus acidophilus and lactobacillus plantarum, friendly bacteria that in-habit the large intestine. These microorganisms can help break down toxins and eliminate them.

Use aspirin and ibuprofen as little as possible. They increase the permeability of the digestive system, allowing allergens and other problematic substances to enter the body.

Do not use antacids. The stomach's acidic environment is designed to kill ingested bacteria and parasites.

To fight digestive problems or heartburn, cut back on saturated fat; eat smaller meals. Chewing on calcium tablets after meals may help. Foods that can exacerbate heartburn include coffee, alcoholic beverages and very spicy foods.

Dr. Galland also recommends not eating for four hours before bed.

Environmental Free Radicals

Detoxing the body may also require taking antioxidant nutrients to fight off what are called free radicals.

Free radicals are caustic molecues thought to be involved in causing many chronic problems such as cancer and heart disease. Free radicals are created within the body and its cells every time a metabolic activity takes place. While the human body has developed its own mechanisms for defending itself against these byproducts of metabolism, exposure to pollution, radiation and other toxins may overburden the body's free radical burden. Scientists believe that taking extra antioxidant nutrients like vitamins C and E and carotenoids (natural substances found in many vegetarian foods) may help prevent damage by free radicals.

Environmental oxidizing agents include ionizing radiation (from industry, sun, cosmic rays, x-rays) ozone and nitrous oxide (from auto exhaust) heavy metals (mercury, cadmium, lead) and cigarette smoke, along with other chemical and compounds from food, water and air. Free radicals are believed to play a role in more than sixty different health conditions, including the aging process, cancer and arteriosclerosis. (Proc Natl Acad Sci USA 1993;90:7915-7922).

The good news? Reducing exposure to free radicals and increasing intake of antioxidant nutrients can shrink the risk of these health problems.

Antioxidant focus

"Antioxidants can't get rid of heavy metals and solvents," says Dr. Glidden, "but they do cut down on the damage they do while they're there. As toxins wander through your body, they generate metabolic reactions, resulting in free radicals. And anti-oxidants mop them up." The liver is the last line of defense in handling toxins; supplements help it regenerate itself.

The body itself does produce enzymes like Superoxide dismutase (SOD) catalase, and glutathione peroxidase which can defend against and defuse many types of free radicals.

Supplements of these compounds are also available to augment the body's supply.

These building block nutrients include the minerals manganese, zinc, and copper for SOD and selenium for glutathione peroxidase. Many vitamins and minerals act as antioxidants. Dr. Crinnion recommends a multivitamin with "a lot of B, especially magnesium."

Since chlorinated pesticides like DDT "rob the body" of B1 and Vitamin A, he says, it's a good idea to supplement these as well.

In addition, acidophilus, a beneficial bacteria that grows in the digestive tract (and found in yogurt) may restore immunity hurt by pollutants. A study on women with recurrent vaginal candidiasis found that acidophilus cut their infections by 300% (Annals Int Med 1992; 116:353-357.)

Another immunity enhancer, colostrum, a natural immune enhancer that promotes cellular repair (Food Res Intl. 1995, 28(1):9-16) can also help the immune system battle pollution.

Vitamin C vs Pollution

A study of vitamin's C's antioxidant properties, conducted by University of Buffalo epidemiologists, and presented at the Annual Meeting of the Society of Epidemiologic Research, revealed that people with higher levels of vitamin C in their blood serum have lower levels of a marker of oxidative stress.

"It is well known that oxidative stress (cell damage caused by free radicals) plays a role in arteriosclerosis, cancer, pulmonary disease and other chronic conditions," said Holger Schunemann, M.D. a research assistant professor of social and preventive medicine at the University of Buffalo and lead author on the study.

"In this population, vitamin C was negatively associated with oxidative stress, suggesting it may play a role in protecting against these diseases." Vitamin C is the "greatest antioxidant," says Dr. Crinnion. "It has even been shown to clear lead from the blood."

Effective E

A powerful fat-soluble antioxidant, Vitamin E scavenges free radicals protecting cells from oxidative damage. Vitamin E, "reverses toxicity of various toxic chemicals," says Dr. Walter Crinnion, "it is also a stabilizer of membranes." A study published in the American Journal of Clinical Nutrition regarding antioxidant vitamin supplementation and lipid peroxidation in smokers even indicates that an antioxidant-supplemented drink can reduce lipid peroxidation and susceptibility of LDL to oxidation in smokers and may ameliorate the oxidative stress of cigarette smoke.

Dr. Glidden recommends E preferably in the form of mixed tocopherols )If you take blood thinners, check with your health practitioner.)

Unfortunately, completely avoiding toxins in today's world is probably impossible. Civilization and toxic chemicals accompany each other hand in rubber-glove-encased hand. Still, with proper attention to nutrition and supplements to keep our bodies detoxifying, we can probably minimize health difficulties linked to these undesirables.

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Vitanet ®

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Date: June 09, 2005 08:41 AM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Federal Court Overturns FDA Ban on Ephedra at Low Doses

Federal Court Overturns FDA Ban on Ephedra at Low Doses

by Rakesh M. Amin and Mark Blumenthal

A Utah Federal District Court recently limited the scope of a year old Food and Drug Administration’s (FDA) Final Rule1 banning the sale of all ephedrine-alkaloid dietary supplements.2 The Court’s ruling has a limited affect on the ability of companies to sell ephedrine nationally, but is important regarding FDA procedure for creating rules and enforcement powers. Ephedrine alkaloids are found primarily in the controversial herb ephedra (Ephedra sincica Stapf., Ephedraceae).

The District Court determined that the FDA’s use of a risk-benefit analysis was against the intent of Congress in passing the Food, Drug and Cosmetic Act,3 which presumes all foods are safe and requires the FDA to prove the existence of a significant or unreasonable risk. The court held that to require food producers to establish a benefit before selling their product places an improper burden on them and was inconsistent with Congress’s intent when it passed the Dietary Supplement Health and Education Act of 1994 (DSHEA) to clearly place the burden of proof of safety of a dietary ingredient on the FDA.4

Secondly, the court determined the FDA had to show by a preponderance of the evidence “a significant or unreasonable risk of illness or injury.”5 Therefore, in order to ban all sales of a given product, the FDA must first prove that the dosage amount in the product presents an unreasonable risk.6 Prior to this ruling, the FDA was not required to consider dosage size before banning a substance.

This ruling has limited effects at the moment since the FDA may appeal this decision. Additionally, the ruling has no effect on the laws of several states (including California, Illinois and New York) which have banned all sales of ephedrine alkaloids in dietary supplements. The ruling also only applies to products containing 10 mg or less of ephedrine alkaloids per daily dosage. Any product exceeding that amount is still banned and will continue to be enforced under the FDA rule.7

The court, in its ruling, specifically precluded the FDA from taking any enforcement action against Nutraceutical Corporation, the company that filed the lawsuit, for its sale of products containing 10mg or less of ephedra and for the FDA to consider further rulemaking “consistent with this Order”.8 However, the court did not specifically instruct the FDA to refrain from taking enforcement action against other brands containing less than 10mg of ephedrine.9 As such, companies considering launching new products containing ephedrine alkaloids are advised to do so carefully.

Nutraceutical Corporation president Bruce Hough was cited in The New York Times as saying that the company’s reason for filing the suit was not based on ephedra and that his company had no plans to begin marketing ephedra supplements in the near future.10 Hough was quoted as saying, “We filed it [the lawsuit] because the FDA established rules that could cause problems to the rest of our business.” Hough was referring to the legal basis upon which the FDA banned the sale ephedra. He told the American Botanical Council that the FDA was applying a drug standard of risk vs. benefit to herbs and dietary supplements – technically foods under the law. [Hough B. Personal communication to M. Blumenthal, Apr. 27, 2005.] His company filed the lawsuit in an attempt to deter FDA’s new procedure for creating what he considered arbitrary rules which contradict the plain meaning of existing federal law (DSHEA).

The American Herbal Products Association (AHPA) issued a statement on April 26 clarifying its policy on the sale of ephedra in dietary supplements.11 AHPA has notified all its members that at this time it is the organization’s policy that none of its members should be selling low doses (10 mg or less) of ephedra in dietary supplements until the FDA has clarified its position on the Court decision. At this time it is not clear whether FDA plans on appealing the decision or will implement the new policy set by the Court.

The court decision does not affect the sale of the herb ephedra in traditional formulations intended for use that is consistent with traditional uses, e.g., pulmonary complaints, and are dispensed by licensed healthcare practitioners.

As might be expected, court’s decision has stimulated a new round of media and congressional criticism of the relative safety of herbs and dietary supplements as well as DSHEA. For example, a highly critical article by Chris Mooney was posted on the website of the American Prospect on April 25.12 The Prospect is relatively influential in Democratic and progressive political circles in Washington. The article uses language such as the court decision is a “scandal” and a “disturbing ruling”, refers to DSHEA as “a terrible law” and a “peculiar and misguided law” and the “wrongheaded standards encoded in the DSHEA”, and repeats the often-cited media mantra about “unregulated herbal supplements” and that the “FDA has been hamstrung and effectively rendered impotent.”

More information regarding the sale of ephedrine products or FDA regulations in general is available from the law offices of Rakesh M. Amin at (312) 327-3382 or rakesh@amin-law.com.

References

1 21 C.F.R. Pt. 119, Final Rule Declaring Dietary Supplements Containing Ephedrine Alkaloids Adulterated Because They Present an Unreasonable Risk (Published February 11, 2004) (Effective April 12, 2004) available at /dockets/98fr/1995n-0304-nfr0001.pdf

2 Nutraceutical Corporation and Solaray, Inc. v. Lester Crawford, D.V.M., Acting Commissioner, U.S. Food and Drug Administration, et al., Case No. 2:04CV409TC, U.S. District Court for the Central District of Utah; available at gov/reports/204cv409-28.pdf

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Date: May 13, 2005 08:38 AM
Author: Darrell Miller (dm@vitanetonline.com)

Sulforaphane Stimulates the Body's Cancer-Fighting Enzymes

by Richard Conant, L.Ac, C.N.

The health benefits of vegetables were known historically, long before researchers began seeing a connection between vegetable consumption and cancer prevention. Over the last twenty years, evidence concerning this connection has steadily accumulated. The latest and most promising findings reveal that specific vegetable constituents—"phytochemicals" to use current scientific parlance— enhance the body's defenses against cancer.

This article will focus on one phytochemical in particular, a sulfur-containing compound called "sulforaphane." Found in Cruciferous vegetables such as broccoli, sulforaphane may prove to be one of our most powerful cancer prevention allies. Recent studies have shown that sulforaphane stimulates, or "induces," "Phase two enzymes." These enzymes are an integral part of the body's elaborate detoxification system that renders carcinogens inactive. This detoxification system turns carcinogens and other toxic substances into harmless molecules that are excreted from the body.

We need not fear carcinogens—the body is equipped to deal with them.

These findings, coupled with an appreciation of the body's ability to defend itself against carcinogens, have the potential to dramatically change the way we look at cancer and substances in the environment that "cause" cancer. We need to minimize unnecessary exposure to carcinogens, and the staggering quantity of hazardous chemicals in the environment remains an urgent health concern, for cancer and many other health problems. But, knowing the body is equipped with the means to defend itself against toxins, we do not need to fear carcinogens as perhaps we have in the past.

The natural world is full of carcinogens.

What's more, even if you eat 100 percent organic food and live in a environment free of toxic man-made chemicals, you are still being exposed to carcinogens every day of your life. Food is the primary route of this exposure. Plants, for their own defense, produce over 99% of all the pesticides in agricultural products.1 Almost all foods—in their natural state—contain tiny amounts of naturally-occurring, potentially carcinogenic chemicals.

The point is not to trivialize the concern over environmental toxins. The point is that the natural world is full of toxins that are not man-made. These substances have been around since before we appeared, which is why we have evolved with a highly efficient system for neutralizing them before they can damage our cells and initiate the complex process that produces cancer.

Broccoli sprouts are a concentrated source of cancer-fighting sulforaphane.

We cannot avoid carcinogens. What we can do is support our internal detoxification system. Sulforaphane is a powerful tool in this effort. We can start by following the often-repeated advice to eat a variety of vegetables every day, and include broccoli in our menu.

There is an even richer source of sulforaphane than broccoli itself. In September 1997, a group of scientists at the Johns Hopkins University School of Medicine made a breakthrough discovery— broccoli sprouts contain ten to one hundred times more sulforaphane than mature broccoli.2 Vegetable sprouts are generally regarded as exceptionally healthy foods. Broccoli sprouts now look like a shining star, especially when it comes to cancer prevention.

For those lacking the time or inclination to keep a fresh supply of broccoli sprouts on hand, broccoli spouts have been processed into an extract that is even more concentrated in sulforaphane. More on this later.

What have researchers learned about broccoli consumption and cancer rates?

More than 200 epidemiological studies—studies which track groups of people over time to uncover realtionships between variables such as diet and the incidence of disease—have invesitgated the connections between vegetable consumption and various forms of cancer.1 It should be understood that findings from epidemiological research are generally not regarded as conclusive; these studies are not controlled, and often use data gleaned from questionnaires, which are an imprecise method of gathering information. (In the case of diet questionnaires, for example, the study subjects may or may not record their food intakes with 100 percent accuracy.)

Epidemiological studies look for trends. To be credible, these trends need to show up consistently, in different population groups. Findings from the vegetable intake/cancer studies easily meet these criteria; the number of studies is large and the trend is consistent—vegetable consumption is strongly associated with a lower risk of developing cancer.

What about broccoli in particular? A paper published in the September 1996 issue of Cancer Epidemiology, Biomarkers & Prevention analyzes epidemiological data gathered from 94 studies concerning the cancer preventive effect of brassica vegetables.3 (The Brassica genus, part of the Cruciferae family, includes broccoli, cabbage, kale, cauliflower and brussels sprouts.) The data suggest that broccoli consumption reduces the risk of some of the most feared forms of cancer, including stomach and lung cancer.

Now, to put these data into a balanced perspective, the researchers point out that in most of the studies reviewed, brassica vegetable consumption was reported as part of the total vegetable intake. "In hardly any epidemiological studies was the effect of brassica vegetables separated from the effect of total vegetables or other vegetables by adjusting for consumption of these variables. Therefore, it is difficult to sort out whether the observed observation was attributable to brassica vegetables, to vegetables as a whole, or to other vegetables," they noted.

This uncertainty is a good example of why epidemiological studies alone do not give us open and shut conclusions. But the paper also adds that the apparent anti-cancer effect of brassica vegetables agrees with "the results of experimental studies in which brassica vegetables reduced mammary tumor incidence, hepatic tumor size, numbers of tumors per liver, tumor frequency, and the number of pulmonary metastases when given to rodents before or after a carcinogen insult."3

When you put together a plausible trend from epidemiological research with results of experimental studies that agree with the trend, and then add additional research that reveals the underlying mechanism for these observations, a clear picture begins to take shape. And, indeed, we now have a fairly good idea as to just how brassica vegetables, especially broccoli, help prevent cancer.

How sulforaphane helps prevent cancer from developing.

To see how sulforaphane works, let's look at a brief overview of the body's detoxification system.

The detoxification of carcinogens and other toxic substances takes place in the liver, and involves two distinct enzyme-driven processes or "phases". Phase one enzymes neutralize toxins by various routes. Some of these convert toxins into substances that are immediately eliminated. However, other Phase one steps convert toxins into intermediate products which are carcinogenic themselves, and require further treatment before they can be excreted. Phase two enzymes do this vital job. Phase two enzymes deactivate these carcinogenic metabolites of Phase one, and the final breakdown product is then eliminated once and for all. (For an excellent review of this subject, see Encyclopedia of Natural Medicine, by Drs. Michael Murray and Joseph Pizzorno.4)

Phase two is critical. If Phase one is in good working order, but Phase two is not, the potential threat from carcinogens increases. It is vitally important to keep Phase two operating well. This is where sulforaphane plays its cancer preventive role. Sulforaphane is a powerful inducer of Phase two enzymes.5,6

Broccoli sprouts-the ideal source of sulforaphane

Sulforaphane is one among a group of phytochemicals called "isothiocyanates." (These occur in brassica vegetables largely as "glucosinolates," which are precursors for isothiocyanates2,12 When the plant is crushed, glucosinolates are converted to isothiocyanates.) Sulforaphane induces Phase two enzymes exclusively, leaving Phase one enzymes alone. This means it helps reduce the load of carcinogenic Phase one intermediates without adding to the load by stimulating Phase one.8,9

As reported by the Johns Hopkins University research group, broccoli sprouts are an "exceptionally" rich source of sulforaphane (in the form of "glucoraphanin, sulforaphane's glucosinolate precursor). And broccoli sprouts have another advantage over mature broccoli. They contain almost no indole glucosinolates, phytochemicals present in mature broccoli that "can enhance tumorogenesis."2

Broccoli sprouts as an extract, now available as a dietary supplement, takes the concentration of sulforaphane to the next level. This recently developed nutraceutical product contains a potent 20 to 1 extract of three-day old fresh broccoli sprouts.

One 125 mg capsule supplies the same amount of sulforaphane as 125 grams, or about 5 ounces, of mature broccoli. Taking just one capsule a day is like eating two pounds of broccoli per week, which equals the intake of cruciferous vegetables believed necessary to obtain their health benefits.

References

1. Steinmetz, K.A. Potter, J.D. Vegetables, fruit, and cancer prevention: A review. J Am Diet Assoc. 1996;96:1027-1039.

2. Fahey, J.W., Zhang, Y., Talalay, P. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. 1997; 94:10367-10372.

3. Verhoeven, D.T.H., et. al. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiology, Biomarkers & Prevention 1996;5:733-48.

4. Murray, M. Pizzorno, J. Encyclopedia of Natural Medicine. Rocklin, CA: Prima Publishing;1998:110-120.

5. Zhang, Y. Talalay, P, Cho, C., Posner, G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure. Proc. Natl. Acad. Sci. 1992;89:2399-2403.

6. Gerhäuser, C. et. al. Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes. Cancer Research 1997;57:272-78.

7. McDanell, R., McLean, A.E.M., Hanley, A.B., Heaney, R.K., Fenwick, G.R. Chemical and biological properties of indole glucosinolates (glucobrassicins): A review. Fd. Chem. Toxic. 1988;26(1):59-70.

8. Talalay, P. Mechanisms of induction of enzymes that protect against chemical carcinogenesis. in Advances in Enzyme Regulation, Vol. 28, Weber, G., Ed., 1989: Pergamon Press.

9. Prochaska, H.J. Santamaria, A.B., Talalay, P. Rapid detection of enzymes that protect against carcinogens. Proc. Natl. Acad. Sci. 1992;89:2394-98.