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Vitamin Deficiencies on the Rise: Addressing the Increasing Awareness of Micronutrient Deficiencies   
Date:
May 28, 2024 03:46 PM
Vitamin Deficiencies on the Rise: Addressing the Increasing Awareness of Micronutrient DeficienciesIn recent years, there's been a significant uptick in the awareness of vitamin and mineral deficiencies across global populations. Micronutrients, though required in minuscule amounts, play a critical role in bodily functions, from metabolism to immunity. Despite advancements in healthcare and education, many individuals are still unaware of their own nutritional gaps, with modern diets contributing significantly to these deficiencies.
Factors Contributing to Micronutrient DeficienciesModern Diet TrendsThe rise in convenience foods, which are often calorie-dense but nutrient-poor, has significantly impacted nutritional intake. Fast foods, processed meals, and sugary snacks have become staples in many diets, particularly in urban settings. These foods are typically low in essential vitamins and minerals such as vitamin D, vitamin B12, iron, and magnesium. As people increasingly rely on these quick, palatable options, it often comes at the expense of nutrient-rich fruits, vegetables, lean proteins, and whole grains.
Lifestyle ChangesAnother contributing factor to vitamin deficiencies is the shift in lifestyle patterns. Longer work hours, increased screen time, and reduced physical activity mean that individuals spend less time outdoors. This has a particularly detrimental effect on vitamin D levels, which are naturally synthesized when skin is exposed to sunlight. Furthermore, high-stress levels and poor sleep quality can deplete essential nutrients, exacerbating the issue.
Agricultural PracticesChanges in agricultural practices have also had an inadvertent impact on the micronutrient content of food. Soil depletion, the use of chemical fertilizers, and genetically modified crops can lead to lower levels of vitamins and minerals in produce. Consequently, even those who consume fruits and vegetables regularly might not be getting the expected nutrient benefits.
Fast Food and Nutrient DeficienciesIt is becoming increasingly clear that the widespread consumption of fast food plays a significant role in the rise of vitamin deficiencies. Fast food items are often designed to be highly palatable and energy-dense. However, they are typically laden with unhealthy fats, sugars, and sodium while lacking essential nutrients. Regularly consuming these foods can lead to an imbalance in diet, where the body might get ample calories but insufficient vitamins and minerals. For instance, studies have shown that diets high in fast food are linked to lower intakes of vitamins A and C, dietary fiber, calcium, and iron. These deficiencies can trigger a range of health issues, from diminished immune function and poor bone health to increased susceptibility to chronic diseases.
Addressing the Issue: Food-Based MultivitaminsTo counteract these dietary deficiencies, many nutrition experts recommend incorporating a food-based multivitamin into daily routines. Unlike synthetic supplements, food-based multivitamins are derived from whole foods and contain a spectrum of vitamins and minerals in their natural forms, which can be more readily absorbed and utilized by the body.
Benefits of Food-Based Multivitamins
Selecting a High-Quality MultivitaminWhen choosing a food-based multivitamin, look for products that:
In Summary:The rise in micronutrient deficiencies is a concerning trend that underscores the importance of balanced nutrition. While modern lifestyles and dietary habits contribute significantly to this issue, there are effective ways to address it. Reducing the intake of nutrient-poor fast foods and incorporating food-based multivitamins can help bridge the gap and support overall nutritional needs. By making informed dietary choices, individuals can foster better health and mitigate the risks associated with vitamin and mineral deficiencies.
Take Charge of Your Health TodayUnderstanding the impact of micronutrient deficiencies on overall health is the first step towards making informed dietary choices. By addressing nutritional gaps and prioritizing whole, nutrient-rich foods, you can significantly improve your well-being. We invite you to explore our range of high-quality, food-based multivitamins designed to complement your daily diet and ensure you receive the essential nutrients your body needs.
Shop Now and Transform Your HealthDon't wait until deficiencies affect your vitality. Visit our online store to find the perfect multivitamin for your lifestyle. Our products are crafted with organic, non-GMO ingredients, and are free from unnecessary additives and fillers. Embrace a healthier you with the power of natural, food-based nutrients.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=6603) Pregnant women are not getting enough omega-3 
Date:
September 30, 2017 01:07 PM
Omega-3 fatty acids are important for everyone. Pregnant women need them but aren't getting enough. This may be due to the fact that women are told to avoid certain fish during pregnancy but that is a common source of these important fatty acids. They are found in other foods, though, so it is still possible to get enough of them. If you are pregnant and don't know what to eat you can ask a doctor or dietician. You need to be healthy so the baby inside you can also be healthy. Key Takeaways:
"The first ever study on the intakes of omega-3 polyunsaturated fatty acids in pregnant women in New Zealand, has found only 30 per cent are getting the recommended daily amount." Read more: https://medicalxpress.com/news/2017-09-pregnant-women-omega-.html
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=5295) Researchers find that an egg a day can increase growth in young children
Date:
June 21, 2017 07:14 AM
Eggs have the potential to contribute to reduced growth stunting around the world.Poor nutrition is a major cause of stunting, along with childhood infections and illnesses.eggs were great food for young children with small stomachs.Eggs contain a combination of nutrients, which we think is important.Children in the treatment group had higher dietary intakes of eggs and reduced intake of sugar-sweetened foods compared to control.They theorized that getting very young children to eat eggs might have an impact. Read more: Researchers find that an egg a day can increase growth in young children
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4860) Vitamin D plays essential role in health
Date:
March 11, 2017 03:59 AM
Are you getting the D? Vitamin D plays a critical role in your good health and well-being, and a lack of this nutrient can impede your lifestyle in so many ways. It is time to learn the importance of Vitamin D and how amazingly it works to keep you in the best of health possible. If you're not getting enough of the D, it is time to change that. After you learn the benefits, you'll be excited to make these changes. Key Takeaways:
"Various benefits are touted, some appearing quite outlandish, and their exaggerated claims often have no scientific backing." Read more: https://www.google.com/url?rct=j&sa=t&url=http%3A%2F%2Fwww.miningjournal.net%2Flife%2F2017%2F03%2Fvitamin-d-plays-essential-role-in-health%2F&ct=ga&cd=CAIyGjVkYjY3ZDViNDdiNGM3ZTc6Y29tOmVuOlVT&usg=AFQjCNGba_nWcdt4N_0QAfF46Q8-hksvig
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=4100) Most Americans Have Inadequate Intakes of Vitamins and Minerals: Can Supplements Help?
Date:
December 22, 2016 06:39 PM
It is estimated that 90% of humans are deficient in one or more essential vitamins and minerals. While some may be due to inadequate absorption, most is believed to be due to poor nutrient intake. Vitamin B12 and vitamin D have been identified as two of the worst deficiencies. Although nutrient needs should be met primarily by diet, there are supplements available if the diet doesn’t allow for a proper balance. A multivitamin may be recommended for most people who are at risk of a deficiency. Key Takeaways:
"Evidence clearly shows that many Americans obtain less than the required amounts of a number of vitamins and minerals, and that dietary supplement use increases intakes and reduces rates of nutritional inadequacies." Reference:
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3686) Warning: 4 common vitamins no one told you become toxic if you take too much
Date:
October 28, 2016 03:59 AM
Vitamins are used to enhance your life when you're not eating the right foods. Many vitamins are sold in which you can use to gain these necessary vitamins and minerals. But, before you head out to the vitamin store to make a purchase, take a look at these four common vitamins that, when taken in too large of a quantity, can be toxic. Key Takeaways:
"Excess of some vitamins can cause problems due to toxicity, although far fewer people experience side effects from multivitamin pills compared to the number affected by prescribed medications. Even so, as Goldilocks might have said, it’s important to obtain not too much, not too little, but just the right amount."
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=3340) Health Benefits Of Fish Oil
Date:
November 01, 2013 10:44 AM
Some of the important health benefits of the omega-3 supplementation to the young, the old and everybody in between include: 1. Improved synthesis of proteins The omega-3 fatty acids are renowned for their consequences on heart health and inflammation even though they really have powerful effects on boosting protein synthesis. Out of the 2 most essential omega-3 fatty acids, EPA and DHA, it seems EPA has the more significant effects in the synthesis of proteins. 2. Reduced breakdown of proteins Decreasing protein breakdown and/or increasing protein synthesis leads to muscle growth. The EPA plays 2 unique functions in the growth of muscles. It reduces protein breakdown and increases protein synthesis by acting on totally different mechanisms in metabolism of muscles. 3. Improved immune function It is a huge disappointment when a person gets sidelined from his or nutrition and training program because he or she is sick. Fish oil plays an important function in performance and fitness. This is because it supports the white blood cells (major cells in immunity) function. 4. Enhanced sensitivity of the insulin Excessive adipose tissue (body fat) interrupts the ability of the body to maintain the sensitivity of insulin and control blood sugar level in fat tissue and muscle. The omega-3 fatty acids can improve insulin sensitivity if supplemented in the diet. 5. Enhanced delivery of nutrients to the cells Increased intakes of omega-3 supplements actually alter the composition of cell membrane. Higher levels of omega-3 in cell membrane facilitates the passage of nutrients out and in of the cell. 6. The capacity of omega-3 fatty acids to enhance metabolism is less proven than theoretical. However, as the health of a cell improves during nutrient delivery, the rate of metabolic rate of the cell is also enhanced. 7. Decreased inflammation The omega-3s are renowned for their benefits to heart health. When fish oil is consumed at effective amounts, they have positive effects on the inflammatory of the body. 8. Enhanced brain health The DHA, component of omega-3 fatty acids, play an important function in brain health. It is transmitted from the expectant mother the unborn child, and is crucial for the developing brain. 9. Decreased Triglyceride levels The EPA has been proven to support lower levels of Triglyceride. References
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2868) Benefits Of Zeaxanthin
Date:
February 07, 2012 08:14 AM
With aging, our eyes and the associated muscles weaken. They can degenerate and lose our ability to see properly. Eyes enable us with vision to see the world, and losing the eyesight will halt affect our daily activities and movements. People are frequently worried about losing their sight, and try to find supplements that can prevent the loss of vision. However, this debility can be prevented. Supplements should be ideally be all natural, healthy, and with no side effects. Zeaxanthin is an important nutrient for eye health. This is found in found in green leafy vegetables, and also in other foods like eggs. Zeaxanthin fulfills most of the requirements that most people look in a supplement. WHAT IS ZEAXANTHIN Zeaxanthin and lutein are carotenoids that filter out the harmful high-energy wavelengths of light, and also act as antioxidants in the eye. This helps to maintain and protect healthy eye cells. Out of the six hundred carotenoids found in nature, only these two, Zeaxanthin and Lutein are deposited in high quantities in the retina (macula) of the eye. Unfortunately, our body does not synthesize the zeaxanthin and lutein it requires. This is the reason why green vegetables, eggs and other sources of these carotenoids are essential to proper nutrition. Daily intake of zeaxanthin and lutein through diet, beverages, fortified foods or nutritional supplements and is very important for the protection and continuation of good eye health. Studies have indicated that zeaxanthin and lutein can help to lessen the chance of chronic eye illnesses, including cataracts and age-related macular degeneration (AMD). Zeaxanthin, is also a bioflavonoid, that besides its benefits to ocular health, has been linked to providing many health benefits, including its anti-inflammatory property. Because of zeaxanthin being a carotenoid category bioflavonoid, its main action is over the blood vessels; it works by supporting the blood vessels around the retina area with their proper function. ZEAXANTHIN BENEFITS Zeaxanthin is both an anti-inflammatory phytochemical and an antioxidant; hence this has been used as a preventative measure for macular degeneration and cataracts. Its antioxidant properties keep eyes from being damaged from the harmful ultraviolet rays of the sunlight. Overall, zeaxanthin keeps the eye healthier, and looking younger. ZEAXANTHIN AGAINST CATARACT: Our natural eye collects and focuses light on the retina, and to properly provide this function continuously, the lens must remain clear throughout life. A major cause of cataracts is oxidation of the lens, which clouds it. Antioxidant nutrients, like zeaxanthin and lutein neutralize the free radicals or the unstable molecules associated with this oxidative stress associated with retinal damage. Thus, these phytochemicals play a role in cataract prevention. Higher dietary intakes of vitamin E, zeaxanthin and lutein can considerably reduce the risk of cataract formation. ZEAXANTHIN AGAINST AGE-RELATED MACULAR DEGENERATION (AMD): Zeaxanthin and lutein reduces the risk of AMD. In fact, studies like AREDS2 (Age-Related Eye Disease Study) are being conducted with supplements containing ten mg lutein along with two mg zeaxanthin each day, how it affects or lowers the chance of developing this degeneration. FOOD SOURCES OF ZEAXANTHIN Zeaxanthin is naturally found in some green leafy vegetables like kale and spinach. Other sources of zeaxanthin include egg yolk, yellow squash and bell-peppers. This makes zeaxanthin available as a completely natural nutrient, with no side effects.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2559) Natural Vitamins for the Heart
Date:
July 06, 2010 02:44 PM
The cardio-protective effect of vitamin E seems to come from its ability to bind to LDL cholesterol, which protects it from free-radical induce oxidative damage along with the consequent buildup of atherogenic plaque. Low levels of vitamin E in the blood are a predictive factor of heart health almost 70% of the time. Studies on the general population have suggested that there is a link between the intake of calcium and blood pressure. Although results of the studies have not been consistent, there are several studies showing that calcium supplementation can lower blood pressure in those individuals who experience hypertension. Overall, those intakes of calcium that are sub-optimal contribute directly to hypertension. It seems that dietary calcium reduces blood pressure by normalizing intracellular calcium levels. Supplementation with magnesium is of benefit for the treatment of cardiac arrhythmias and the prevention of potassium depletion. Both magnesium and potassium play an important role in the functioning of the heart. Several studies have found that there is improvement in heart function in those patients that have cardiomyopathies when they supplement with magnesium. Since magnesium acts in so many ways to enhance cardiac function and optimize cellular metabolism, magnesium is widely recognized as a critical nutrient for general cardiac support. Several double-blind studies have taken place in those patients that experience various cardiomyopathies in order to show the benefits of CoQ10 supplementation. One study reported an 89% improvement rate in 80 cardiomyopathy patients who were treated with CoQ10. The coenzyme also appears to moderate blood pressure through the usual mechanism, as it lowers cholesterol levels and also stabilizes the vascular system with its antioxidant properties. Because of this, it is able to reduce vascular resistance. Several studies on CoQ10 supplementation have confirmed that this nutrient posses the ability lower both systolic and diastolic pressures by up to ten percent. There are other nutrients that play important roles in optimizing cardiovascular health and reducing hypertension. Among these nutrients are gamma tocopherol, calcium, magnesium, l-carnitine, acetyl-l-carnitine, procyanidolic oligomers, phenolic compounds, and lycopene. As you can see there are many natural supplements that can help the cardiovascular system. Remember to always consult your doctor before adding supplements to your diet while on prescription drugs. Look to your local or internet health food store for quality vitamins, herbs, and specialty formulas to boost your health and wellness.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2169) Antioxidants and your health
Date:
May 17, 2010 10:44 AM
There is an impressive amount of scientific evidence supporting the health benefits of supplementing with a wide variety of antioxidants. Consequently, there are many health practitioners who have begun to recommend high dietary intakes of these crucial nutrients in order to prevent against oxidative stress. It was anticipated over two decades ago by leading researchers that high-dose supplementation with antioxidants is developing a significant role in the prevention and treatment of a lot of today’s common illnesses. It should be noted that antioxidants do not work in isolation. When an antioxidant neutralizes a free radical, it, itself, is oxidized and must be regenerated by another antioxidant before it can be used again. Because of this, it is crucial to supplement with a wide variety of antioxidants, in order to reflect what actually occurs in nature. Vitamin C, an aqueous-phase antioxidant, is the main guard against oxidative attack in the extra-cellular matrix, as well as within the cytoplasm of the cell. Vitamin C happens to be a substrate for eight different enzyme systems that are involved in various cellular functions. Among these functions are collagen synthesis, ATP synthesis in the mitochondria, and hormone biosynthesis. Its main antioxidant partners are vitamin E and beta carotene, both of which help to regenerate vitamin C. Of all the antioxidants, it seems as if vitamin E offers the greatest protection against heart disease because of its ability to protect the cardiovascular system from oxidative damage. It is lipid-soluble, making it an important component of the cell membrane, where it works to protect the cell against lipid peroxidation and control oxidation-induced inflammatory events. Recently, the gamma tocopherol form of vitamin E has shown a great deal of promise in its ability to reduce the risk of several oxidative stress related disease. Beta-carotene is a member of a diverse group of photosynthetic pigments. It plays a huge role in human nutrition. As an antioxidant, it possesses a double-bond structure that allows it to react effectively with single oxygen radicals, absorbing and diffusing their energy. Beta-carotene also acts as a precursor for vitamin A by supplying a portion of the body’s requirement for the vitamin. This act alone plays a central role in the chemistry of vision. Beta-carotene and vitamin A both prevent the oxidation of cholesterol, reduce oxidative damage to DNA, and disable oxygen free radicals that are produced by exposure to sunlight and air pollution. These antioxidants are also involved in the activation of gene expression and the control of cell differentiation. When combined together, vitamin C, vitamin E, and beta-carotene produce and important antioxidant trio that plays a huge role in fighting oxidative and inflammatory events. There are several other antioxidants that should be noted due to their ability to work synergistically with the vitamin C, vitamin E, and beta-carotene trio. These include vitamin A, alpha-lipoic acid, lycopene, coenzyme Q10, and the antioxidant mineral, selenium. In order to determine whether a nutrient provides antioxidant support, scientists question whether the product contains vitamin C, vitamin E, vitamin A, beta-carotene, alpha-lipoic acid, lycopene, coenzyme Q10, and selenium and to what strength these vitamins and minerals are per serving.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2160) Agave Nectar
Date:
April 08, 2010 04:31 PM
Reading through the attack articles and blogs that have surfaced recently one could think that using agave is bad for one's health. These claims are utterly false and misleading. They are extreme views drawn from extreme examples and applied way out of context. They are propagandizing and clearly designed to frighten, not educate. All of the fears and concerns associated with the overconsumption of sugars and calories in general have been unfairly cast on agave. What is a "healthy" sweetener? One that you use moderately and sensibly. Health concerns related to fructose and caloric sweeteners are all dependant on the overconsumption of them. All foods have calories and it is the overall consumption of calories that lead to obesity and related issues, not any one food source.
Agave's caloric value is comparable to the other sweeteners in the category. Due to its greater sweetness though, less agave is used compared to the others, so agave actually can reduce caloric consumption per serving. This is due to a higher fructose content. The higher content does not mean higher consumption though, due to the smaller portion used. But, it is not the single serving that matters, it is the number of servings which lead to the overconsumption issues which may result in health concerns. As a reference point, 9-10 teaspoon servings of agave would be the approximate caloric equivalent of one 16 oz soft drink. With this perspective, is agave really being overconsumed as a choice of sweetener for home use? Every single health issue which the attackers have tried to associate with agave is really the result of a caloric overconsumption issue. There are no documented issues with normal, moderate consumption of agave or sweeteners in general as part of our everyday diet. For reasons unknown, some have attempted to isolate agave from the real world and real world conditions with the goal of inhibiting agave's use. They play on people's fears, reference false information and fail to address health issues in any meaningful way. The purpose of this article is to debunk the controversial misinformation surrounding agave. All information debunking the myths and misinformation is based on current science and facts. It is our goal to provide you with useful information so that you can make your personal nutritional choices in a well-informed, science-based manner. The Agave Controversy: Exposing the fraudulent article by Rami Nagel By Dr. Susan Kleiner, PhD, RD, FACN, CNS, FISSN And Craig Gerbore, CEO Madhava
The controversy about agave syrup was manufactured by the publication of a single article on the internet, which has been reproduced and adapted for virtually every other article produced on the internet and other media venues. That article, written by Rami Nagel and published on Naturalnews.com, was highly biased and full of inaccuracies, half-truths and misinformation about agave. Since the Naturalnews.com article has been the sole source of nearly all other popular articles in public media, we want to set the record straight with science-based, reliable information to offer a more balanced resource to those interested in learning more about agave syrup. According to the description on the Naturalnews.com website, Rami Nagel is a "citizen journalist". This means that Mr. Nagel is self-employed, and not employed as an in-house journalist by the website. He wrote and published the article without any editorial or content oversight, and the editor of the website, Mike Adams, makes it clear that the article was not checked for incorrect or inaccurate information or facts. The introduction to the article, written by Mr. Adams, states that readers had written to comment that Mr. Nagel's resources were biased with conflicts of interest due to their financial interests in competing sweeteners, such as brown rice syrup. So even the website editor himself states that the article is not fact-checked, and it is biased and unbalanced. Who is Russ Bianchi? The sole resource interviewed for the article is Russ Bianchi, identified by the author as Managing Director and CEO of Adept Solutions, Inc. Mr. Bianchi has clear conflict of interest ties to the sweetener industry. We have documentation of the fact that Mr Bianchi had plans to market a product named Replace. It was to be touted as a low calorie alternative sweetener composed of natural and artificial ingredients! Mr Bianchi was prevented from marketing this sweetener as the result of a lawsuit against him by the owner of the formula. Mr Bianchi is quoted by Nagel extensively and exclusively. Many, if not all, of his statements are blatantly false or misrepresentations of fact. He is clearly propagandizing against agave nectar. Was anyone else interviewed for this article?
Yes. Craig Gerbore, president and owner of Madhava Agave Syrup, was extensively interviewed by the author but no parts of that interview were included in the article. It is important to note that neither Mr Nagel or Mr Bianchi have not made themselves available for questions on their statements since the articles appearance. They remain out of sight and have entirely avoided the controversy their statements created. What is agave nectar? The opening line of this paragraph in the article by Mr. Nagel states: "The principal constituent of the agave is starch, such as what is found in corn or rice." This is absolutely false. There is no starch in agave. The source of carbohydrate in agave syrup is inulin, a polysaccharide made up primarily of strings of fructose units. Starch is a polysaccharide made up of strings of glucose molecules. They are significantly different, and this difference is why agave syrup is naturally sweet. The very basis of the argument presented by Mr. Nagel is false. The Process The agave plant is a succulent, similar to a cactus. The agave sweetener comes from both the Salmiana agave plant and the agave Tequilana (Blue Agave) which are both organically farmed in Mexico and certified organic by USDA approved certifiers. As the salmiana plant grows it produces a stalk called the "quiote" and when this is removed, a natural liquid called "aquamiel". The liquid is collected from the plant, while Blue agave pinons are harvested and shredded to remove the similar juice. Either can be naturally processed thermally or by enzymes into agave nectar. The juice of the plant is not naturally sweet. The string of connected fructose units that makes up the major proportion of inulin does not have a sweet taste, but when the fructose units are separated (the process is called hydrolysis) by the addition of an enzyme, similar to digestion, or thermally for most blue agave, the syrup becomes quite sweet. That is the entire processing chain for agave nectar. There are no additives, other ingredients or chemicals in Madhava agave nectar. It is absolutely pure and organic and GMO free. ? Mr. Nagel claims that agave syrup is a "refined corn fructose" similar to high fructose corn syrup. This is absolutely false. There is no relationship between agave syrup and high fructose corn syrup in any way, including the source of the product, or the manufacturing process. ? Mr. Nagel refers to a "confidential FDA letter" from Mr. Martin Stutsman, claiming that agave is fraudulently labeled. We contacted Mr. Stutsman at the United States Food and Drug Administration, and his response made it clear that there was never a "confidential FDA letter". He did publish a public letter referenced in an FDA document as "FDA letter from Martin Stutsman to Dr. Eric Wilhelmsen (Wilhelmsen Consulting), May 8, 2000", regarding evaporated cane juice, a topic wholly unrelated to agave syrup. ? He continued in his response to us that the paragraph in Mr. Nagel's article inaccurately reflected the substance of his comments in the document. This link will take you to the original document in which the letter was referenced (reference #2): //www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/GuidanceDocuments/FoodLabelingNutrition/ucm181491.htm In fact, Mr. Nagel fabricated the entire story of the letter. Mr. Stutsman is a lawyer, not a doctor. The quotes were completely taken out of context from the document, and the quotes never referred to agave syrup at any time. Nagel goes on to further misrepresent Mr. Stutsman's intent in the published document by weaving in other inaccurate information that is thoroughly unrelated to the original document. Mr Bianchi's subsequent statements on labeling issues are false and without merit. Mr. Nagel is clearly caught red-handed. He has misrepresented the words of a government official, lied about the facts, and twisted the information to achieve his own agenda. This strategy is repeated throughout the article. ? Mr. Nagel continues his deceptive writing by referring to a quote by the late Dr. Varro Tyler in his book, The Honest Herbal. The first line of the paragraph is a direct quote from the book. Nothing else in that paragraph remotely resembles anything else found in Dr. Tyler's book. Mr. Nagel is trying to claim that agave syrup contains large quantities of saponins, and that they can be harmful to health. Here is the debunking of that paragraph: 1. Dr. Tyler does not include the variety of agave plant used for agave syrup. 2. The entire discussion is about the use of the sword-shaped leaves and the stem. Agave syrup is produced from the natural liquid in the plant. The saponins are isolated from the leaves of the plant. 3. There is no documented evidence to suggest agave syrup contains worrisome levels of saponins and the entire rest of the discussion about health dangers is fabricated and false. Sugars People are going to continue to consume sweet food and drink. There are only three categories of choice to sweeten food. Those are artificial sweeteners, stevia, or caloric sweeteners from natural sources, sugars. Most people will not choose artificial. Many will not choose stevia. That only leaves the category of sugars. In this group, agave is a good choice due to its organic quality, ease of use, neutral flavor, low glycemic index and the fact that less is used to equal the sweetness of the others in the category. The sweeteners in this category are composed of three primary sugars used to sweeten foods: glucose, fructose and sucrose. These sugars belong to a class of compounds known as carbohydrates. "Saccharide" is a term that denotes sugar, or substances derived from sugar. Monosaccharides are simple or single sugars; disaccharides are derived from two joined monosaccharides and when they are hydrolyzed, or separated, they yield two molecules of simple sugar. Strings of more than two sugar molecules are called polysaccharides. This category includes compounds such as starches, cellulose and inulin. Glucose and fructose are monosaccharides. Glucose and fructose are found abundantly in nature in fruits and plants. Sucrose is the disaccharide formed by the joining of glucose and fructose, also known as table sugar. When comparing their relative sweetness, glucose is the least sweet tasting, sucrose is next, and fructose is the sweetest of the three sugars, measured as 1.4 times sweeter than table sugar. Because it is so sweet, people typically use less fructose when sweetening foods compared to sucrose. ? In the article by Mr. Nagel he states , "fructose is not what is found in fruit. Commonly, fructose is compared with its opposite and truly naturally occurring sweetener, known as ‘levulose' (made by nature)..." Another fabrication. In fact, levulose is just another name for fructose. There are various nomenclatures used in the scientific naming of compounds. Fructose and levulose are exactly the same thing; the names are interchangeable. It is no different than if you called your father, "dad", and your sibling called your father, "father". He would still be the exact same person. Fructose and levulose are different names for the exact same thing: a sugar found in nature. Mr. Bianchi also is quoted to say that the body does not recognize the fructose in agave. This is another false piece of propaganda which demonstrates just how far he is reaching. If this were true, it would have no impact on us. He immediately contradicts himself with the claims of detrimental effects caused by the overconsumption of fructose. Using Sugars Sugars can be compared to each other in their ability to raise blood sugar levels by using the Glycemic Index. The scale is set from zero to 100, where low numbers do not have much impact on blood sugar levels, and high numbers raise blood sugar levels quickly. Fructose is very low on the scale. Because agave syrup is high in fructose, it has a rating of 32 or lower. Honey, which has a higher proportion of glucose to fructose, has a Glycemic Index of 58. Sucrose has a Glycemic Index of 68, and glucose, serving as the index standard, is 100. All sugars, whether fructose, glucose, sucrose or others, contribute 4 calories per gram to our total diet. 1 teaspoon of sugar = 4 grams = 16 calories In addition to calories, sugars sweeten our foods offering a desirable taste and adding enjoyment and pleasure to our dining. During cooking and baking, sugars allow for browning and the unique consistencies of syrups, candies, frostings and frozen desserts. The varieties of sugars, such as crystallized table sugar, brown sugar, raw sugar, molasses, honey and agave nectar, among others, contribute different properties and flavors to foods. When you add your own sugar to foods you are in control of how much sugar you use. Most people would never add as much sugar as do the food manufacturers. Moderate amounts of sugar can certainly be enjoyed as part of a healthy diet for an active individual. Natural sugars are easily metabolized and utilized by the body, offering a very efficient source of fuel for physical and mental activity. Of course, sugars should be used in moderation in the diet. This can control calories and help create a diet that is dense in nutrients. Impact of sugar on health and disease ? The remainder of Mr. Nagel's article works to link agave syrup with the increased incidence of obesity, diabetes, metabolic disease, and the general rise of morbidity and mortality in the population. This is an overconsumption issue involving far more than the occasional use of agave. Here are the facts: • Rats that are fed a high fructose diet become obese and will develop the chronic diseases associated with obesity: insulin resistance, diabetes and metabolic disease. • No one should eat a diet that reflects this type of experimental diet. • Too much sugar in the diet, whether from fructose, glucose or sucrose, can be unhealthy. Diets high in sugar promote tooth decay and periodontal disease; create an overabundance of calories and a deficit of nutrients. This scenario typically leads to weight gain and the development of chronic disease. • Active individuals can include a moderate amount of added sugar in their diet without negative health consequences. When calorie intake is balanced with physical activity, sugar serves as an efficient source of fuel for muscles, the brain and the central nervous system. • According to the World Health Organization (2003), individuals can healthfully include 10% of their daily calories from added sugars. This translates into 200 calories for a 2000 calorie diet, or 12½ teaspoons of added sugar daily. Clearly, one can safely add a couple of teaspoons of sweetener to a cup of tea or coffee, or have a little sweetened food without worrying about their risk of developing disease. • Agave syrup, which is sweeter than other sugars and low on the Glycemic Index scale, is a good choice to include as one of the added sugars in your diet because you will use less sugar (and therefore fewer calories) and minimally raise blood sugar levels. Just a teaspoon of agave: the healthy use of sweeteners in your diet We all want to live healthier and longer lives. Diet and nutrition plays a key role, impacting our health and our ability to perform physically and mentally now and into the future. Food offers us not only sustenance, but also pleasure and enjoyment. Food is present in so many parts of our lives: at celebrations, business events, family events, religious and spiritual occasions, sports outings, the focus of our family meals, intimate dinners, and sometimes just the excuse to socialize. Sweet foods make us feel good. Sugar allows for the elevation of serotonin in our brains, the "feel good" neurotransmitter that elevates mood, helps us focus, and in the evening, helps us relax and sleep. Sugar is a source of energy for our muscles, brain and central nervous system. Without sugar our bodies will not function at peak capacity. Too much sugar, however, is not good. In small amounts sugar energizes us, but in large doses, repeated throughout the day, day in and day out, sugar puts stress on the body. The extra calories can lead to weight gain and obesity, which in time can lead to chronic disease. In the short term, high sugar intakes can lead to a nutritionally deficient diet and a sense of being on an emotional roller coaster. So be selective about your use of sugars and use them in moderation in your diet. Just like all foods, a variety will enhance the nutritional content of your diet and the flavor and tastes that you can enjoy. Since sugars come in different forms and have different flavors, they can be used most effectively in specific foods and beverages. For instance, agave syrup is liquid and less viscous than honey, making it easy to mix into cold liquids like iced tea and coffee, and is great to add to cold unsweetened cereals for a little sweet taste. Agave's mild flavor allows chefs and bakers to sweeten foods lightly, without overpowering the taste of the dish. Pay attention to how much sugar is added to your diet every day. Read labels so that you know when sugar is added to manufactured foods. Keep the consumption of added sugars in your diet to no more than 10% of your total daily calorie intake so that you have plenty of room for nutrient dense foods like fruits, vegetables, grains, dairy, protein-rich foods, nuts, seeds and healthy oils. Remember that nutrition is a science based on facts. We are making great advances in our understanding of the science of foods and nutrition. Beware of people with hidden agendas using fear tactics to influence your choices. Don't take their opinion at face value. What are their credentials? What conflicts of interest do they have? If they do not disclose conflicts, then assume that they are manipulating the truth. Most of all enjoy food. Think about what you need to eat to promote whole health. Don't overindulge, but don't deprive yourself of the bounty of wonderful tastes, either. Use celebrations as occasions to enjoy your favorite foods and try new ones. A teaspoon or two of sugar easily fits into the diet of an active, healthy person. Agave syrup offers an organic low-glycemic choice for those looking for that option. Resources for this article: Charley H. Food Science, 2nd Edition. John Wiley & Sons, New York, NY, 1982. Figlewicz DP et al. Effect of moderate intake of sweeteners on metabolic health in the rat. Physiology and Behavior 98:618-624, 2009 Johnson RK et al. Dietary sugars intake and cardiovascular health: A scientific statement from the American Heart Association. Circulation: Journal of the American Heart Association, 2009 Tyler VE. The Honest Herbal, Third Edition. Pharmaceutical Products Press, New York, NY, 1993.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=2152) Multiple Vitamins
Date:
February 04, 2009 09:17 AM
It has been announced that it pays to take your vitamins, as the American Medical Association has completely reversed its previous anti-vitamin stance after twenty years and is now encouraging all adults to supplement daily with a multiple vitamin. After this decision, a review of 38 years of scientific evidence has convinced the Journal of the American Medical Association (JAMA) to rewrite its policy guidelines regarding the use of vitamin supplements. It is common knowledge that today's diet is not providing sufficient nutritional value to keep chronic diseases at bay. Although nutrient intakes in North American are generally sufficient to avoid overt vitamin deficiencies, sub-clinical deficiencies are extremely common. Most vitamins and minerals come mainly from fruits and vegetables, causing us to need at least five daily servings of each. Studies have found that the number of servings of fresh fruits and vegetables is well below the recommended fiver servings per day, with the intake of dietary iron, folic acid, and calcium being significantly below recommended levels for adolescent girls. Not many people know that cardiovascular disease is a problem that has been cultivated by modern society, with the first report on cardiovascular disease in America being published in 1912. At that time, the disease was so rare that it took years to find. In less than 100 years, the changes to our lifestyle, environment, and to the food we eat have made cardiovascular disease the number one killer in North America. A groundbreaking report on July 13, 2000 tied the development of most cancers to lifestyle and the exposure to environmental and occupational risk factors. Although a genetic influence was not negated, as it appears to account for about 30% of total cancer risk, the findings placed the blame on poor dietary habits, smoking, alcohol consumption, lack of exercise, and exposure to environmental toxins. It has been recommended that a diet made up of plant-based foods which include vegetables, fruits, and grains is essential. Stroke, the third-leading cause of death in the most developed countries for decades, occurs when blood flow to the brain is cut off due to a thrombotic event in one of the major arteries feeding the brain. A major cause of disability among adults and a principal factor in late-life dementia, small strokes can often go unnoticed. Because hypertension is the major cause of stroke, potassium and its blood pressure-lowering abilities are often helpful. Additionally, nutrients such as folic acid, bioflavonoids, polyphenols, and assorted antioxidants play an important role. The consumption of citrus fruit juices that contain high levels of vitamin C, and cruciferous vegetables like broccoli, cabbage, Brussels sprouts, bok choy, and cauliflower give protection against stroke. Not only are we not eating enough of the proper food groups, the foods we do eat are often short in vital nutrients and high in calories. Nothing can replace the value of a diet that is carefully balanced. However, in today's high-stress world, we often face a absence of physical activity and a surplus of meals on the run, consisting of fast-food and processed foods that lack nutritional value. We should never neglect the importance of a well-balanced diet that is high in fruits and vegetables and we should make every opportunity to eat as close to the earth as possible. Unfortunately, in today's fast-food world, it is hard to get away from the high-calorie, low-nutrition, over-processed, corporate food culture. If you value your health, it makes sense to take the extra step and start supplementing your diet with nutritional supplementation, as it is your personal health insurance to help you age gracefully. Stop into your local or internet health food store and look for a good multiple vitamin supplement to help boost your current diet.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1963) Noni Fruit Extract
Date:
November 22, 2008 09:34 AM
Tahitian Noni juice can promote a healthy body in many ways. These Noni benefits are conferred by the phytochemicals contained within the fruit pulp, but before discussing the benefits of Noni let's first have a look at what it actually is. Morinda citrifolia is also known as the Indian or beach mulberry tree, and is a member of Rubiaceae family. Although it originated in Southeast Asia, it has spread all the way to French Polynesia and the Dominican Republic. It is mainly cultivated in Tahiti for its fruit, known as cheese fruit or Noni fruit. Although it is a staple food in some areas of the Pacific, it has a pungent smell and a bitter taste, and often eaten either raw or cooked only in times of famine. However, the fruit is particularly rich in phytonutrients, and many people swear by the Noni benefits it to maintain a glowing healthy body, free from disease and many of the health problems from which most people suffer. The strange thing about it is the taste: you would not drink Tahitian Noni juice by choice, nor eat the fruit, so how were these Noni health benefits discovered? Hunger likely explains it: those forced to eat it through hunger were likely the lucky ones, who actually ate a nutritional diet even though they were eating a fruit normally eaten only in times of famine. Among the conditions that Noni fruit is believed to protect you from are cardiovascular disease, high cholesterol levels, asthma, cholesterol, strokes, migraines, a weak immune system, arthritis and some cancers. Many of these conditions should give you a clue as to the nature of the phytochemicals contained within the fruit, since most of them involve free radical attack and immune system response. Prior to examining thee diseases and conditions in detail, let's have a look at the chemicals the fruit has been established to contain. It is rich in dietary fiber, offering 100% of the Dietary Reference Intakes of the Institute of Medicine for each 100g serving, and also contains enough carbohydrate to meet 55% of you DTI needs. However, that is just the start. The Noni pulp powder contains ten times the DRI of Vitamin C, and large quantities of Vitamin B3 niacin), potassium and iron. The Tahitian Noni juice itself contains few nutrients, and only the Vitamin C is retained to any useful level. It is therefore the pulp powder that offers the major nutritional benefit. In fact, because it has to be pasteurized at high temperature to meet regulations the for liquid product, Noni juice loses most of its nutritional content, and even the 31% Vitamin C content is surprising since that too is destroyed at high temperatures. It is the high phytochemical content of Noni powder that renders it such an important supplement, and a scan down the following components will give you an idea of how the fruit got its reputation. The known Noni benefits are obtained from: Lignans: these are phytoestrogens that have been reported to offer a reduced risk of ovarian and breast cancers, osteoporosis and also cardiovascular disease. They possess antioxidant properties and although reports as to their effectiveness are varied, they appear to have beneficial health effects. Flavanoids: These are phenolics, including asperulodisic acid and rutin. The former is believed to be effective against certain cancers, while rutin, also contained in buckwheat, is a strong antioxidant that strengthens capillaries, and also helps to prevent atherosclerosis and heart disease. Catechin and epicatechin: strong antioxidants that help prevent heart disease, strokes, diabetes and cancers. It also protects your skin against the harmful effects of the ultra-violet component of the sun's rays. Catechin is a form of flavanoid, and one of the more powerful of the antioxidants needed to destroy the free radicals that would otherwise ravage your body through the destruction of your body cells. B-Sitosterol: a plant sterol that is believed to reduce the cholesterol in your blood, but still requires scientific proof, even though there is plenty of evidence to support its effect. Plant sterols are the basis of the cholesterol-lowering yoghurt drinks that you can but in your local supermarket. This list is not exclusive, and there are several other phytochemicals found in Noni pulp powder that are believed to confer significant health benefits, but that are still seeking scientific support. The fact that such support has yet to be provided is not a reason to doubt their effectiveness, although the above benefits are sufficient to justify the reputation of this nutritional supplement that few have heard about. There have been only around 110 reports on Noni research since the 1950s, so it is not surprising that the scientific proof is weak, although of these around 100 have appeared since the year 2000. Don't forget that there was no proof for the effectiveness of penicillin until it was discovered! Even the biochemistry of the components of Tahitian Noni juice, such as the polysaccharides not mentioned in the above list, is in the early stages of research, and an increasing number of traditional remedies are being found to have a valid scientific and medical basis. These polysaccharides are a form of dietary fiber with probiotic properties that can be fermented by bacteria in the gut to form short chain fatty acids that possess many beneficial health properties. Take the heterocyclic iridoids, for example. These are unknown to most people, yet they are found in many plants that have extensive medicinal properties, and might be responsible for many of them. They appear to possess anti-inflammatory, antiviral and antispasmodic properties, and support the cardiovascular system, the immune system and help to maintain a healthy blood sugar level. These are also contained in Noni pulp powder. Another component of Noni fruit that most people have not heard of is damnacanthal. This inhibits certain tyrosine kinesis that basically have a controlling effect on the division of body cells. They particularly inhibit the Ras genes, responsible for some cancers due to uncontrolled cell division. Damnacanthal can prevent Ras genes from causing these cancers.
There are many more benefits that Tahitian Noni juice, or particularly the powdered Noni pulp, can confer, and it is recommended that it be taken as a supplement by anybody needing a general health tonic since it possesses such a wide variety of beneficial properties. The Noni benefits which those that use it enjoy area available to everyone, even though it is one of the lesser known of the beneficial health supplements.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1937) Trace Minerals
Date:
August 05, 2008 01:13 PM
Unlike macro-minerals such as calcium, which the body needs in gram amounts, trace minerals such as iron, selenium, zinc, silicon, chromium, sulfur, and copper are only needed in milligram or micrograms. However, these small quantities do not reflect the importance of trace minerals, as inadequate intake can have huge effects on the body. Lets discuss a few of these trace minerals. Iron deficiency is the most common nutritional deficiency worldwide, with 20 to 50 percent of people affected. The average body contains only one teaspoon of iron, but this mineral is crucial in oxygen transportation throughout the bloodstream and into cells. A lack of iron will starve the body of oxygen and energy, which cause the symptoms of iron deficiency to be fatigue, foggy thinking, irritability, headaches, and lethargy. A lot of athletes have inadequate iron intake, impairing their exercise performance as it decreases hemoglobin levels and the amount of oxygen that is delivered to the muscles while it increases the time that is needed to recover from exercise. Iron is also important in immunity, with optimal iron intake strengthening the immune system and building resistance to colds, infections, and diseases. Even though inadequate intake is a common concern, too much can also cause health problems including stomach and intestinal cramps, nausea, and constipation. The most important function of selenium is its antioxidant enzyme glutathione peroxidase. This enzyme is invaluable in protecting red blood cells and cell membranes from free radical damage. Selenium works closely with vitamin E, sometimes replacing it in certain situations. Selenium holds an important role in maintaining the immune system and has been shown to reduce the risk of many health problems which include several types of cancer, heart disease, rheumatoid arthritis, and certain birth defects. Zinc is a valuable antioxidant that supports many aspects of the immune system. Zinc works in the eyes to protect them against sunlight-related free radicals. Zinc supplements have been found to slow the progression of macular degeneration, but high intakes of zinc and other antioxidants have been shown to lower the risk of developing this eye disease in the first place. This mineral can reduce the severity and duration of the common cold when in lozenge form, if started within 24 hours of the first cold symptom and taken every couple of hours. Taking 50mg of zinc daily or higher amounts for short periods of time is a good idea, but amounts over 150mg daily could cause metallic taste, stomach upset, or impair immune function. Many modern diets contain extremely low amounts of silicon, especially since food processing removes much of the silicon. Silicon improves the elasticity and suppleness to skin that has been damaged by excessive skin exposure. Silicon is also important in natural bone formation, since deficiencies in silicon lead to bone weakness and sluggish wound health. Bone mineral density can be improved in people with osteoporosis by raising the intake of silicon. Chromium is important in maintaining blood sugar levels, as well as many other roles in the body. Chromium deficiency impairs the blood sugar-insulin relationship, while chromium supplementation improves insulin response. Studies have shown that supplementing with chromium picolinate improves diabetes management by lowering blood sugar, insulin, cholesterol, or triglyceride levels and reducing the reliance on blood sugar medications. This mineral is also important in the metabolism of fat and carbohydrates. Finally, Sulfur is needed in the joints to keep the connective tissues within them strong and stable. One source of sulfur, MSM, has been shown to significantly relieve pain and improve use of knee joints in studies. Through all of the above, one can see that trace minerals are extremely important contributors to health, even in small amounts.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1853) Fruits and Vegetables for a Healthy Mind!
Date:
April 23, 2008 03:06 PM
Although the effects of nutrition on health and school performance are often cited, few research studies have examined the effect of diet quality on the academic performance of children. A new study published in the Journal of School Health studied how good nutrition impacts children’s academic performance by identifying specific dietary factors that are associated with the academic performance. Using multilevel regression methods to examine the associated between indicators of diet quality and academic performance, researchers found that students reporting increased diet quality were significantly less likely to fail the literacy assessment. In particular, students with an increased fruit and vegetable intake and lower caloric intake of fat were significantly less likely to fail the assessment. In particular, students with an increased fruit and vegetable intake and lower caloric intake of fat were significantly less likely to fail a assessment. Dietary fat intake was also demonstrated as important to academic performance. They surveyed 5,000 fifth grade students in Nova Scotia, Canada, gathering information on the dietary intake, height, and weight of each student, and examining socio-demographic variables. Using a food frequency questionnaire, researchers calculated each student’s intake of foods from recommended food groups as well as energy and nutrient intakes. They calculated the diet quality index-international (DQI-I), a composite measure of diet quality. The elementary literacy assessment was used to assess academic performance, requiring students to read a variety of materials and answer written questions based on texts. (Journal of School Health, April 2008, volume 78, number 4, pages 209-2158)
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1767) Liquid Calcium Magnesium – Proactive Support – Supports Optimal Bone Health*
Date:
July 06, 2007 02:14 PM
Liquid Calcium Magnesium – Proactive Support – Supports Optimal Bone Health*
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Reduce the risk of osteoporosis with calcium*
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Osteoporosis affects middle-aged and older persons. A lifetime of regular exercise and a healthy diet that concludes calcium builds and maintains good bone health and may reduce the risk of osteoporosis later in life. Daily intakes above 2,000 mg are not likely to provide any additional benefit to bone health.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1582) Breast Cancer and Natural Supplements
Date:
May 11, 2007 10:47 AM
Breast Cancer and Nutritional Supplements
There is probably nothing more frightening for a woman than the discovery of a lump in her breast. Cancer and all its consequences quickly come to mind. This quick association may materialize, in part, because no woman is immune. Most have a friend, a sister, a mother, or a coworker who has been diagnosed with the disease. And they know how difficult dealing with this disease can be. Fortunately, 80% of all breast lumps are not cancerous. Most are cysts or a benign clump of tissue.
Over her lifetime, a woman’s breasts undergo many, many changes. From before puberty and on, breast tissue is continually evolving. Breasts often feel different before menstrual cycle, returning to normal a few days after. Pregnancy certainly causes changes in a woman’s breasts, as does breastfeeding. And as women age, breast tissue becomes less dense.
Because of these continual changes, breast tissue especially requires adequate nutrition. While everyone benefits from a healthy diet, there are additional nutrients from which women can specifically benefit.
In this issue of Ask the Doctor, we will discuss breast cancer and the vast amount of research that has explored the role nutrition plays in this serious and still deadly disease. Specifically, we will discuss how two B vitamins, calcium D-glucarate, broccoli extract, green tea, maitake mushrooms, and iodine can all help prevent breast cancer.
Q. How can these nutrients prevent breast cancer?
A. Scientists learn a lot about disease from simply observing what is happening around them. One observation that has been recognized for many years is that certain cultures have very low incidence of breast cancer. Women n
Moms (and dads) have also learned a lot about diseases simply by observing what is happening in their families. They have notices that certain vegetables play a large role in the prevention of all types of diseases, including cancer. And, accordingly, they have been urging their offspring to eat their vegetables for several generations.
Building on these observations, scientists have designed and carried out many studies to determine what it is about these nutrients that can prevent breast cancer. What they have discovered, so far, follows. Let’s start with the B vitamins.
Vitamin B12
Deficiencies of this vitamin can result in a serious type of anemia. Nerve damage can also occur if B12 levels are too low. Researchers are now investigating whether breast cancer may, in part, be caused by a B12 deficiency as well.
At
Another study, this one taking place in a laboratory setting, discovered that vitamin B12, applied directly against experimental breast cancer cells, actually stopped the cancer cells from growing. The researchers conducting the experiment believe that giving vitamin B12 to women with breast cancer as part of a chemotherapy regime, might help keep the cancer in check.
Folic Acid
Low folic acid intake is linked to the development of all cancers. This is because folic acid is crucial to the making and continual repair of DNA, the molecule that carries our genetic code. A recent study discovered that high intakes of folic acid might actually reduce the risk of breast cancer. The researchers looked at the diets of over 2600 women. During interviews with the researchers, the women reported what they usually ate. Once the data was collected, the results showed that women, who ate lots of foods that contained folic acid, had much lower rates of breast cancer.
There is no clear-cut, single cause of breast cancer. Many factors are required for the disease to appear. One such factor is estrogen. A recent study showed that women who developed breast cancer tended to have higher levels of estrogen circulating in their bodies than women without breast cancer. This means that women who got their periods before age eleven or entered menopause after age fifty-five have a higher risk of breast cancer. This also supports the theory that the number of menstrual cycles a woman has affects her risk for breast cancer.
Another factor is drinking alcohol. Because alcohol raises estrogen levels, if a woman consumes even moderate amounts of alcohol her risk of breast cancer also is increased. The link between alcohol and breast cancer may even be stronger than other dietary links. However, an important study has discovered that folic acid may uncouple this link.
A very large study of over 34,000 women recently studied the effect of folic acid on the risk of breast cancer. This project was part of the Nurses’ Health Study, an ongoing, long-term study that looks at nutrition’s role in the development of disease. The women in the folic acid and breast cancer study were followed for 12 years. The participants completed detailed food questionnaires that provided the researchers with important data.
The women were divided into four groups:
1. Women with low folic acid levels and drink alcohol
2. Women with high folic acid levels and rink alcohol
3. Women with low folic acid levels and don’t drink alcohol
4. Women with high folic acid levels and don’t drink alcohol
Within these four groups the women were further divided into subgroups according to the amount of alcohol they consumed each day and their specific folic acid intake.
The researchers found that women who consumed the lowest amounts of folic acid and drank at least one alcoholic beverage a day had the highest rate of breast cancer. In contrast, women who had high intakes of folic acid and also drank at least one alcoholic beverage a day, had the same rate of breast cancer as the women with high folic acid intakes who did not drink. In other words, women who had high levels of folic acid in their diet erased their alcohol-related increase in breast cancer risk.
Calcium D-Glucarate
It seems estrogen can be both friend and foe. While women need the hormone to soften skin, thicken hair, and fill out hips and breasts, estrogen can also nourish breast tumors, helping them grow bigger, stronger, and more deadly. Thanks, in part, to good nutrition, American women get their periods early and go through menopause alter in life. Women today also have fewer pregnancies; families with one or two children are quite common.
All of these factors increase the time women’s bodies are exposed to estrogen. As we discussed before, longer exposure means increased opportunities for estrogen to cause trouble. It is also a troubling fact of modern life that we are continuously exposed to cancer-causing chemicals and toxins. These toxins come in part from contaminants in the food we eat and pollutants in the air we breathe.
The body does have a system that eliminates some of the excess estrogen and toxic chemicals before they can cause harm. In the liver, they are bound or attached to a chemical called glucuronic acid. The bound toxin or estrogen is then excreted in bile and eventually eliminated as a waste product in the stool.
However, an enzyme called beta-glucuronidase can break this bond between estrogen and glucuronic acid. When this happens, the hormone or toxin is released from its bone, capable of causing harm once more. Increased beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependant cancers like breast cancer.
Fortunately, scientists have discovered that a natural substance found in foods calcium D-glucarate (CDG) can stop the activity of beta-glucuonidase. CDG keeps the harmful estrogen bound to glucuronidase. While CDG is found in fruits and vegetables, the amounts may not be sufficient to maintain effective levels to stop beta-glucuronidase.
CDG has been shown in experimental studies to significantly stop beast cancer growth. And several human trials are currently underway with CDG to determine its capability to decrease the breast cancer risk in women at high risk for the disease.
Iodine
There are some very interesting connections between breast tissue and thyroid tissue. Iodine is an essential trace element present in a hormone of the thyroid gland and is involved in several metabolic functions. One iodine function is the protection of breast tissue from cancerous cells.
In a laboratory study, researchers exposed breast cancer cells and breast tissue without any cancer to a type of seaweed that contains high levels of iodine. The seaweed killed all of the cancerous cells, yet did not harm the normal breast cells. Japanese women frequently eat this type of seaweed and have very low rates of breast cancer. The study’s researchers believe one reason for this low incidence of breast cancer may be the iodine in the seaweed.
And, for some as yet unknown reasons, women who have thyroid cancer are at higher risk of developing breast cancer. While they are unsure why this happens, researchers are continuing to study this link, and support of healthy thyroid function remains an important consideration.
Broccoli
For quite some time, scientists have observed that cruciferous vegetables, such as broccoli, cabbage, and cauliflower, significantly reduce the risk of disease, including cancer. It seems a phytochemical in broccoli sulforaphane, is one of the chemicals responsible for this beneficial activity. Sulforaphane increases certain enzymes in the body called phase 2 enzymes that deactivate cancer-causing chemicals.
Breast cancer cells exposed to sulforaphane in several lab experiments showed that the compound inhibited the growth of the cancer cells up to 80 percent. Researchers are in the process of setting up clinical trials to study sulforaphane’s effect in women who have breast cancer.
Green Tea
There is a tall amount of research, including finding from the Nurses’ Health Study, that suggest green tea beverage consumption is associated with a lower incidence of breast cancer. In fact, researchers have long noted the low rates of breast cancer in
The active compound in green tea responsible for breast cancer inhibition is epigallocatechin-3 gallate or EGCG. When breast cancer cells are exposed to EGCG in lab experiments, the cells stop growing, lose their ability to replicate, and die.
In a recent study, researchers discovered that drinking green tea prevented the recurrence of breast cancer in women who have previously been diagnosed and treated for the disease. This study involved over 1100 Japanese women. The women who drank green tea every day had very low rates of their breast cancer returning.
Maitake Mushrooms
For thousands of years, maitake mushrooms have been linked to good health in those who eat them. Called “dancing mushrooms” (possibly due to their wavy, rippling appearance or possibly due to the little dance of joy mushroom hunters perform when they find them in the woods), maitakes contain an important compound called D-fraction.
Not only does the D-fraction in maitake mushrooms stop the growth of cancerous tumors, it also alerts and stimulates immune cells (including macrophages and natural killer cells) to fight the disease. Maitake also inhibits some of the mechanism that promotes metastasis, or spread, of cancer cells in the lymph and bloodstream.
Because of this success, maitake is now being used in clinical trials of women with breast cancer. One study reported significant improvement of symptoms, including reduction of the tumor. The maitake was given to breast cancer patients in addition to standard chemotherapy.
Q. Should these nutrients be used in place of traditional treatment for breast cancer?
A. Absolutely not. None of these nutrients can cure breast cancer. However, they can be a part of a validated plan of treatment. If you have breast cancer, talk to your health care practitioner about these nutrients. Remember, nutritional supplements are just that: supplements to food, medication, and treatment. They are intended to enhance and prevent, not replace.
Conclusion
Despite apprehension in performing self-breast exams, women are very proactive in their health. Yearly mammograms and pap tests have been an important part of their lives for many years, and newer and more accurate diagnoses are emerging. The prevention of health problems in themselves and their families has always been a high priority for women. And for women, nutrition has played an important part of health problem prevention.
Nutritionally speaking, what benefits your breasts benefit your whole body. However, as we have learned, there are specific links between nutrition and developing breast cancer that seem to be fairly strong.
Making a few changes may reduce the risk of developing the disease. The nutrients listed here, vitamin B12, folic acid, calcium d-glucarate, iodine, broccoli, green tea, and maitake mushrooms can be an important part of a woman’s preventative health regimen.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1537) Learn about Bone Health!
Date:
April 20, 2007 12:43 PM
Bone Health Approximately 44 million American women and men aged 50 and older have osteoporosis (severe bone loss) or osteopenia (mild bone loss), with women being affected about twice as often as men. At least 1.5 million fractures of the hip, vertebra (back or neck), or wrist occur each year in the United States as a result of osteoporosis, and the annual cost of treating this disorder is nearly $14 billion and rising. Unfortunately, the toll in human suffering and loss of independence is even greater. In this issue of Ask the Doctor, we will discuss the risk factors for osteoporosis and some key nutrients you can add to your diet that can minimize bone loss and reduce your chances of developing this disease. Q. What are the risk factors for osteoporosis? A. Small body frame, underweight, Caucasian or Asian race, a sedentary lifestyle, cigarette smoking, excessive alcohol or caffeine intake, high intake of carbonated beverages (especially colas), and having other family members with osteoporosis all increase personal risk of developing the disease. Certain medical conditions, including diabetes, celiac disease, hyperthyroidism, rheumatoid arthritis, chronic obstructive lung disease, hyperadrenalism, and hyperparathyroidism, are all associated with an increased risk of osteoporosis. Some medications increase the rate at which bone is lost; these include drugs prescribed for the treatment of seizures, drugs used for blood thinning, steroids such as prednisone, aluminum-containing antacids, and loop diuretics (furosemide {Lasix}). Q. Isn’t bone loss just a normal consequence of aging? A. Although bone mass normally declines after the age of 35, bone loss severe enough to cause fractures after just minor trauma (such as bump or fall) seems to be a relatively new phenomenon. Osteoporosis was rare in the late 19th century, and it was not until around 1920 that the condition began to attract attention among doctors. Since that time, the percentage of people who develop osteoporosis has continued to increase. For example, the age-adjusted prevalence of osteoporosis in Q. Can osteoporosis be prevented? A. Engaging in regular weight bearing exercise, avoiding excessive consumption of alcohol and caffeine, and quitting smoking will slow the rate of bone loss. Eating adequate, but not excessive, amounts of protein also enhances bone health. In addition, a growing body of research has shown that supplementing with various vitamins and minerals may not only help prevent, but in some cases actually reverse, bone loss. At least 15 different nutrients have been found to play a role in bone health. Q. What type of calcium is best? A. For most people, calcium salts are absorbed about the same, between 30% and 40% of the administered dose. People who low stomach acid (hypochlorhydria) should not use calcium carbonate, because that form of calcium is absorbed poorly in the absence of stomach acid. Calcium phosphate may be preferable for many older people, because phosphorus is necessary for normal bone formation, the phosphorus intake of older people is often low, and calcium supplements inhibit the absorption of phosphorus. Also, calcium bound to phosphorus is the form in which calcium in the bone is stored, and it has a much greater bone activity than other forms. Q. How much vitamin D is needed to promote strong bones? A. Because vitamin D is produced when the ultraviolet rays from the sun hit skin, people who stay out of the sun, wear sunscreen, or live in a northern latitude (such as Boston or Seattle) where less ultraviolet light reaches the skin, are at increased risk of vitamin D deficiency. In addition, aging decreases a person’s ability to synthesize vitamin D in the skin. Results from five research trials on vitamin D found that supplementation with 700-800 IU of vitamin D per day decreased the number of hip fractures by 26%, but 400 IU per day was ineffective. In addition to enhancing bone health, vitamin D improves nerve and muscle function in older people, thereby reducing their chances of falling down. Supplementation of elderly women with 800 IU of vitamin D per day has been shown to decrease the number of falls by about 50%. Q. Is that much vitamin D safe? A. The Food and Nutrition Board of the Q. Why would nutrients besides calcium and vitamin D is important? A. Bone is living tissue, constantly remodeling itself and engaging in numerous biological functions. Like other tissues in the body, bone has a wide range of nutritional needs. The typical refined and processed American diet has been depleted of many different vitamins and minerals, some of which play a key role in promoting bone health. Not getting enough of one or more of these micronutrients may be and important contributing factor to the modern epidemic of osteoporosis. In addition, supplementing with calcium may cause a loss of magnesium, zinc, silicon, manganese, and phosphorus, unless these nutrients are also provided. Q. What nutrients besides calcium and vitamin D promote healthy bones? A. Magnesium, zinc, copper, manganese, vitamin K, boron, strontium, silicon, folic acid, vitamin B6, vitamin B12, phosphorus, and vitamin C have all been shown to play a role in bone health. Following is a brief description of the role that each of these 15 nutrients play in building healthy bones. Calcium: A component of the mineral crystals that make up bone. Vitamin D: Enhances calcium absorption, prevents falls by improving nerve and muscle function. Magnesium: Important for bone mineralization (accumulation of minerals which form bones). Magnesium deficiency is associated with abnormal bone mineral crystals in humans. In an open clinical trial, magnesium supplementation increased bone mineral density by an average 5% after 1-2 years in postmenopausal women. Copper: Laboratory research has found that copper promotes bone mineralization and decreases bone loss, and that osteoporosis can develop if the diet is deficient in copper. Western diets often contain less copper than the amount recommended by the National Academy of Sciences. In a 2-year double-blind trail, copper supplementation reduced bone loss by 90% in middle-aged women, compared with a placebo. Zinc: Like magnesium, zinc is important for bone mineralization, and also has been shown to decrease bone loss. Low dietary zinc intake was associated with increased fracture risk in a study of middle-aged and elderly men. The zinc content of the diet is frequently low; a study of elderly low-income people found they were consuming only half the Recommended Dietary Allowance for this mineral. Manganese: Plays a role in the creation of the connective-tissue components of bone. Manganese deficiency in laboratory tests resulted in low bone mineral density and weak bones. Manganese deficiency may be associated with the development of osteoporosis. Boron: Supports creation of bone-protecting hormones such as estrogen, testosterone, and DHEA. Boron supplementation prevented bone loss in experimental studies. In human volunteers consuming a low-boron diet, boron supplementation decreased urinary calcium excretion by 25-33%, a change that may indicate reduced bone loss. Silicon: Plays a role in the synthesis of the connective-tissue components of bone. Silicon deficiency has been associated with bone abnormalities. In an observational study, higher dietary silicon intake correlated with higher bone mineral density. In a clinical trial, administration of an organic silicon compound increased bone mineral density of the femur (or thigh bone) in postmenopausal women. B vitamins (folic acid, vitamin B6, and vitamin B12): These three B vitamins have been shown to lower blood levels of homocysteine, a breakdown product of the amino acid methionine. An elevated homocysteine concentration is a strong and independent risk factor for fractures in older men and women. Homocysteine levels increase around the time of menopause, which may explain in part why bone loss accelerates at that time. In a 2-year double-blind trial, supplementation of elderly stroke patients with folic acid and vitamin B12 reduced the number of hip fractures by 78%, compared with a placebo. Strontium: This trace mineral is incorporated into bone and appears to increase bone strength. It also stimulates bone formation and inhibits bone breakdown. Controlled trials have demonstrated that strontium supplementation of postmenopausal women increases bone mineral density and decreases fracture risk. Vitamin K: Best known for its effect on blood clotting, vitamin K is also required for the creation of osteocalcin, a unique protein found in bone that participates in the mineralization process. The amount of vitamin K needed for optimal bone health appears to be greater than the amount needed to prevent bleeding. Vitamin K levels tend to be low in people with osteoporosis. In randomized clinical trials, supplementation of postmenopausal women with vitamin K prevented bone loss and reduced the incidence of fractures. Q. Which form of vitamin K is best? A. Two forms of vitamin K compounds are present in food: vitamin K1 and vitamin K2. Vitamin K1 (also called phylloquinone) is present in leafy green vegetables and some vegetable oils, and vitamin K2 is found in much smaller amounts in meat, cheese, eggs, and natto (fermented soybeans). To make things a little more complicated, Vitamin K2 itself can occur in more than one form. The two most important to this discussion are menaquinine-4 (MK-4, also called menatetrenone), which is licensed as a prescription drug in Research suggests that MK-7 from natto may be an ideal form of vitamin K. The biological activity of MK-7 in laboratory studies was 17 times higher than that of vitamin K1 and 130 times higher than that of MK-4. After oral administration, MK-7 was better absorbed and persisted in the body longer, compared with MK-4 and vitamin K1. Although both have shown ability to prevent osteoporosis in laboratory research, a much lower dosage (600 times lower) of MK-7 is required, compared to MK-4, to obtain beneficial effects. Thus, MK-7 has greater biological activity, greater bioavailability, and possibly more potent effects on bone, compared with other forms of vitamin K. The potential value of MK-7 for bone health is supported by an observational study from Q. Why is strontium so important in building strong bones? A. Strontium is of great interest to bone health researchers and has been studied in very high doses. Surprisingly, lower doses are not only safer for long-term supplementation, but may in fact have a greater impact on bone health than very high doses. Too little, and bone density is impaired; too much and health may be impaired. This is a case where dosing needs to be just right for optimal impact. Therefore, until more is known, it is wise to keep supplemental strontium at less than 6 mg per day. Q. Can people taking osteoporosis medications also take bone-building nutrients? A. Because nutrients work by a different mechanism than osteoporosis drugs, nutritional supplements are likely to enhance the beneficial effect of these medications. Calcium or other minerals may interfere with the absorption of biphophonates such as alendronate (Fosamax) or etidronate (Didronel). For that reason, calcium and other minerals should be taken at least two hours before or two hours after these medications. Also, it is always best to discuss the supplements you are using with your healthcare practitioner to create an integrated health plan. Final thoughts… Bone health ramifications extend beyond osteoporosis and fractures. Bone health is essential for freedom of movement, safety, comfort, independence and longevity. Weak bones do not heal well – sometimes they never heal at all. Osteoporosis-related fractures rob us of our mobility and consign thousands of Americans to walkers and wheelchairs every year. In fact, 40% of people are unable to walk independently after a hip fracture, and 60% still require assistance a year later. The most terrible consequence of fractures related to osteoporosis is mortality. The impairment of the ability to move around freely can cause pneumonia and skin damage leading to serious infections. It is estimated that suffering a hip fracture increases the risk of dying almost 25%. Making bone health a priority now will allow you to reap health dividends for many years to come.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1523) Regulating Blood Pressure Naturally
Date:
March 28, 2007 10:29 AM
Regulating Blood Pressure Naturally
High blood pressure (also known as hypertension) affects about 65 million Americans, or about 1 in 3 adults. There are many potential causes of hypertension, but not necessarily any symptoms. In fact, 30% of the people who have high blood pressure don’t even realize it.
In other words, just because you don’t have symptoms doesn’t mean you don’t have high blood pressure. That’s why it’s called “The Silent Killer.” And, make no mistake about it: high blood pressure is dangerous. It is the number one modifiable cause of stroke. Just lowering blood pressure reduces the chance of stroke by 35 to 40 percent. Other conditions, including heart attack and heart failure can be reduced from 25 to 50 percent, respectively.
In this issue of Ask the Doctor, we’re going to talk about high blood pressure and an exciting natural treatment for lowering blood pressure safely and effectively.
Of course, changing blood pressure numbers depends, in a large part, on the choices we make every day – how much we exercise, the foods we eat, and our lifestyle overall. But, for those times we need extra help, there is a new, scientifically-studied supplement to help us along our path to better health and lower blood pressure.
Blood pressure guidelines from the National Heart, Lung, and Blood Institute.
Q. What exactly is blood pressure?
A. Blood pressure is divided into two parts, systolic and diastolic. Systolic is the pressure of the heart beating. Diastolic is the pressure of the heart and vessels filling. When blood pressure numbers are written out, like “120/80,” 120 is the systolic pressure and 80 is the diastolic pressure. The unit of measurement for blood pressure is millimeters of mercury, written as “mm/Hg.”
Q. What is considered high blood pressure?
A. A person’s blood pressure can naturally vary throughout the day – even between heartbeats.
However, if the numbers are consistently high (over 120 systolic and 80 diastolic), after multiple visits to your healthcare practitioner, you may have either pre-hypertension or high blood pressure.
Young arteries and arteries that are kept young through healthy diet and exercise are typically more elastic and unclogged. Blood flows through them easily and without much effort. However, as we age, our arteries become more prone to plaque buildup (due to diets high in saturated fat and sedentary lifestyles) and don’t “flex” as well under pressure. The result is faster blood flow, all the time. Over the long term, it damages heart tissue, arteries, kidney and other major organs.
To get a better idea of high blood pressure, compare your arteries to a garden hose. When unblocked, a garden hose allows water to flow through it quickly and easily – without any real rush or stress. However, if you block the end of the hose with your thumb, closing it off even a little, water rushes out much more quickly.
For many years, high diastolic pressure was considered even more of a threat than high systolic pressure. That thinking has changed somewhat but high diastolic numbers could still mean organ damage in your body – especially for individuals under 50.
Q. What courses high blood pressure?
A. The reasons for hypertension aren’t always clear. However, there are lifestyle factors that contribute to high blood pressure that you can change:
Body type: Weight isn’t always a reliable indicator of whether or not you’ll have high blood pressure – but the type of weight is. Lean body mass – muscle – doesn’t increase blood pressure levels the way that fat can. However, fat body mass, especially fat around your middle, can contribute to high blood pressure.
Sedentary lifestyle: Too often, many of us sit down all day at work, and then sit down all night at home. Over time, this inactivity usually leads to weight gain, making the heart work harder to pump blood through the body. In a way, it almost seems contradictory, but inactivity usually leads to higher heart rates.
Sodium intake: Sometimes it’s hard to believe how much salt there is in processed foods. However, salt intake in itself is not necessarily bad. For people with a history of congestive heart failure, ischemia, and high blood pressure, sodium is definitely out. For those individuals, it leads to more water retention, which increases blood pressure. (Salt’s effect on water retention is one reason that so many sports drinks have fairly high sodium content – the sodium in the drink prevents your body from sweating out too much water.) But, for healthy individuals, moderate salt intake, especially a mixed mineral salt like sea salt or Celtic salt (good salt should never be white) is fine.
Low potassium intake: Unlike sodium, potassium is a mineral which most Americans get too little of. Potassium helps regulate the amount of sodium in our cells, expelling excess amounts through the kidneys. Low levels of this mineral can allow too much sodium to build up in the body.
Heavy alcohol intake: Having three or more alcoholic drinks a day (two or more for women) nearly doubles an individual’s chance of developing high blood pressure. Over time, heavy drinking puts a lot of stress on the organs, including the heart, liver, pancreas and brain.
Unhealthy eating: Eating a lot of processed or fatty foods contributes to high blood pressure. Adapting a diet that is rich in fruits and vegetables, whole grain products, fish, nuts and magnesium and potassium (like the Dietary Approaches to Stop Hypertension, known as the “DASH” diet) can bring it back down.
Smoking: If you smoke, stop. Smoking damages the heart and arteries – period. Nicotine constricts blood vessels, increases heart rate, and raises blood pressure. This in turn, increases hormone production and adrenaline levels, further stressing the body.
As if that weren’t bad enough, the carbon monoxide in cigarette smoke replaces the oxygen in the blood, making the heart work even harder to make up the difference. Since the effect of a single cigarette can last for an hour, smoking throughout the day leads to continuously revved-up blood pressure.
Some of these factors might sound like a lot to overcome. The important thing to remember is that all of these behaviors are changeable. If you have high blood pressure, modifying any of these can significantly lower blood pressure as part of an overall plan.
Q. What are the blood pressure numbers I should see?
A. Experts consider healthy blood pressure numbers to be 115/75 mm/Hg. The reason? They found that the risk of cardiovascular disease doubles at each increment of 20/10 mmHg over 115/75 mm/Hg. Even small jumps in blood pressure numbers increase the risk of stroke and heart attack.
Q. Okay, so other than diet, exercise and lifestyle changes are there other natural ways or supplements I can use to lower my blood pressure?
A. Yes, in fact, you hear about some of them in the news all the time – fish oil, CoQ10, and garlic. As effective as these symptoms are, they typically lower systolic pressure much more than diastolic pressure.
However, there is a blend of scientifically and clinically studied natural ingredients that lower high blood pressure separately, and work even better when they’re combined. This combination blend contains: dandelion leaf extract, lycopene, stevia extract, olive leaf extract and hawthorn extract.
Every one of these ingredients has been studied and recommended for years. But now, a scientific study on a supplement that combines them in one synergistic formula shows encouraging results for lowering systolic and diastolic blood pressure.
Let’s take a look at each:
Stevia:
Stevia (Stevia rebaudiana) originated in
The leaf of stevia is considered the medicinal part of the plant. Research shows that extracts of the leaf relax arteries and help prevent the buildup of calcium on artery walls – keeping them healthy and reducing blood pressure.
In a long-term, randomized, placebo-controlled clinical study, stevia reduced systolic and diastolic blood pressure. On average, participants’ blood pressure reduced from baseline 150 mm/Hg to 140 mm/Hg systolic and 95 mm/Hg to 89 mm/Hg diastolic.
And, in another double-blind, placebo-controlled clinical study, stevia lowered blood pressure quite significantly – by an average of 14 millimeters of mercury in both systolic and diastolic readings. Those are impressive numbers!
Despite its role as a sweetener, stevia may have a side benefit to for those with hypertension – blood sugar regulation. Scientific studies show that extracts of stevia regulated blood sugar and reduced blood pressure.
A clinical study showed that stevia extract actually improved glucose tolerance by decreasing plasma glucose levels during the test and after overnight fasting in all participants. Regulating blood sugar is very important for those with high blood pressure. When blood sugar levels are high, blood vessels are inflamed. Many people with diabetes have high blood pressure as well. In a paired, cross-over clinical study, stevioside (one of the compounds in stevia) reduced glucose levels in individuals with type 2 diabetes. Further scientific studies show that stevia works to control blood sugar levels by stimulating insulin secretion by the pancreatic beta cells. It shows great potential in treating type 2 diabetes. Further scientific studies show that stevia works to control blood sugar levels by stimulating insulin secretion by the pancreatic beta cells. Its shows great potential in treating type 2 diabetes as well as hypertension.
Hawthorn extract:
Hawthorn (Crataegus spp. Oxycantha) has been used since ancient ties as a medicinal herb – even being mentioned by the Greek herbalist Dioscorides, in the first century AD. Traditionally, it has generally been used for support of the heart. Modern research points to bioflavonoid-like complexes in hawthorn leaf and flower that seem to be most responsible for its benefits on cardiac health, like blood vessel elasticity.
The bioflavonoids found in hawthorn include oligomeric procyanidins, vitexin, quercetin, and hyperoside. They have numerous benefits on the cardiovascular system. Hawthorn can improve coronary artery blood flow and the contractions of the heart muscle. Scientific studies show that the procyanidins in hawthorn are responsible for its ability to make the aorta and other blood vessels more flexible and relaxed, so that blood pumps more slowly and with less effort – sparing the cardiovascular system such a hard workout.
The procyanidins in hawthorn also have antioxidant properties – protecting against free radical cellular damage.
And, hawthorn may also inhibit angiotensin-converting enzyme. Angiotensin-converting enzyme is responsible for retaining sodium and water, and may have roots in our evolutionary development. It influences blood vessel contraction and dilation, sodium and water balance and heart cell development – just about everything that has to do with blood pressure. This may have developed as a way of dealing with periods of drought and stress. By narrowing the blood vessels, the body could guarantee an adequate supply of blood and focus on repairing tissue.
Unfortunately, that can lead to real problems these days. Since many of us live in an industrialized society, and frequently have pretty sedentary lifestyles, conserving sodium just makes the conditions for high blood pressure that much worse.
Like the other ingredients in this combination, hawthorn showed benefits on other body systems, too. In clinical and scientific studies, it not only lowered blood pressure, but also showed anti-anxiety properties and regulated blood sugar.
Olive leaf extract:
Olive leaf (Olea europaea) comes up again and again in scientific and clinical studies as having beneficial effects on hypertension. One of olive leaf’s most beneficial compounds is oleuropein – the same compound that makes olive oil so helpful in reducing blood pressure. Here again, we have to look at the traditional Mediterranean diet, which features voluminous use of olives and olive oil. Not surprisingly, blood pressure is generally much lower in Greek and Italian populations.
But it’s not just the diet – scientific studies showed that oleuropein lowered blood pressure by relaxing the blood vessels and prevented buildup of plaque in arteries. Plus, whether in olive leaf extract or in olive oil, oleuropein works as an antioxidant, too.
Dandelion leaf extract:
Dandelion (Taraxacum offinale) leaves provide a healthy supply of vitamins, much like spinach. In fact, although it has become the bane of North American gardeners and lawn owners, dandelion greens are a component of many gourmet salads.
Medicinally, dandelion has been used for centuries, dating back to ancient
They are a very rich source of vitamin A, and contain vitamin D, vitamin C, carious B vitamins, iron, silicon, magnesium, zinc and manganese, too. Dandelion leaves produce a diuretic effect in the body, similar to a prescription drug. Since one of dandelion leaf’s traditional uses was the treatment of water retention, it’s really not too surprising. Dandelion leaf is also rich in potassium – one of the vital minerals many Americans lack in their diet. So, even though it may act as a diuretic, it replaces more potassium than the body expels.
The diuretic effect of dandelion can relieve hypertension by drawing excess water and sodium from the body and releasing it through the kidneys as urine. Getting rid of extra water and sodium allows the blood vessels to relax – lowering blood pressure.
Lycopene:
If a nutrient can be called exciting, lycopene is it. Lycopene is found mostly in tomatoes and processed tomato products, like pasta and pizza sauce. Related to beta-carotene lycopene shows great antioxidant abilities among its many talents. In fact, it shows even greater free-radical scavenging properties than beta-carotene, its more famous cousin. Healthy intakes of lycopene can guard against a variety of chronic conditions, including lowering LDL (bad) cholesterol, lowering homocysteine levels and reducing blood platelet stickiness that can lead to clogged arteries. It’s even being studied for its protective effect against prostate cancer.
And, for proof, you don’t have to look too far to see the amazing effect lycopene intake can have on health. The Mediterranean diet provides an excellent example. Its high intakes of vegetables, (tomatoes, of course, playing a central role) fish, and whole grains improve cholesterol levels and lower blood pressure. The research on lycopene as a stand-alone nutrient has been compelling. A randomized clinical trial found that not having enough lycopene was associated with early thickening of the arteries.
So, it makes sense that other clinical trials, showed that higher intakes of lycopene frequently meant less thickening of arteries, and a reduced risk of heart attack. In one study, the risk of heart attack was 60% lower in individuals with the highest levels of lycopene. In a multicenter study, similar results were found – men with the highest levels of lycopene had a 48% lower risk of heart attack.
Q. What can I expect taking this herbal combination?
A. You should notice both systolic and diastolic numbers lowering in about two weeks. The scientific study showed that for pre-hypertensive and stage I, (early hypertensive individuals) this combination for ingredients lowers both systolic and diastolic blood pressure.
When you’re taking herbs to support your blood pressure, it’s important to keep it monitored so you have an accurate reading (and record) of your numbers. If you need to, you can pick up a home blood pressure monitoring device. These can retail for anywhere from $30 all the way up to $200, but buying one in the $30 to $50 range is a good idea and money well spent. Consider taking the machine to your local doctor’s office or fire department to have it tested for accuracy against a professional blood pressure monitor. See the chart below for tips on getting an accurate reading from a home monitor.
Tips for Accurate Blood Pressure Monitoring:
-Relax for about 5 to 10 minutes before measurement.
-If you have just come inside from cold outdoors allow yourself to warm up.
-Remove tight-fitting clothing and jewelry.
-Unless your physician recommends otherwise, use left arm to measure pressure.
-Sit, don’t stand.
-Remain still and do not talk while using the monitor.
Q. Are there any side effects?
A. There were no side effects noted in the study. However, because of the mild diuretic effect of dandelion leaf extract, you may notice an increase in trips to the bathroom. It’s always important to make sure you don’t get dehydrated, so you may want to drink more water during the day.
Conclusion:
High blood pressure doesn’t happen overnight. As we get older, the likelihood of developing hypertension increases. And, stressful, fast-forward lifestyles, bad diets and no exercise conspire to raise our blood pressure.
In my own practice I have helped patients move toward a healthier lifestyle, including diet, exercise, and blood-pressure reducing supplements. They live better, more vibrant lives as a result, and their blood pressure normalizes. It really can happen – you can bring your blood pressure back to normal, and this combination of scientifically and clinically validated ingredients can help.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1498) Fruit and Vegetable Lightning drink mixes from Natures Plus
Date:
February 06, 2007 02:41 PM
Enjoy the Rainbow – the Color Wheel of Fruits and Vegetables
We’ve all heard the statistics, and have probably seen the signs in the produce section of our favorite grocery store: eating 5 servings of fruits and veggies a day is important,
Chances are also pretty good that we’ve also seen the newest food pyramid, encouraging Americans to “eat a rainbow of frits and vegetables.” That is, choose from the rich variety of colors for the best all-around health benefits.
In this Ask the Doctor, we’re going to look at the unique health components of different colored fruits and vegetables, and why they’re so important. Plus, we’ll learn about supplemental options, like fruit and vegetable drink mixes, for those days when our diets just aren’t that great.
Q. What’s the big deal about fruits and vegetables?
A. Well, for the main reason that they are whole foods – created by nature (or at least generations of farming) and are rich in a variety of nutrients. Processed foods can’t match the health benefits of strawberries or broccoli – items that have fiber, vitamins, and enzymes built right in.
Q. What does “eating a rainbow” of fruits and vegetables really mean?
A. This is simply an easy way of remembering to get as much color variety in your diet as possible to maximize your intake of a broad range of nutrients. The colors of fruits and vegetables are often a tangible clue to the unique vitamins and other healthy substances they contain. Getting a variety of colors, therefore, means getting a variety of the essential nutrients your body needs to stay healthy and strong.
Enjoying the Rainbow: Fruit and Vegetable Benefits:
Q. Can you tell me a little more about the healthy components of fruits and vegetables?
Let’s take a look at some of the most well-studied and important nutrients:
Quercetin is found in apples, onions and citrus fruits (also is hawthorn and other berries and apple-related fruits usually used in traditional herbal remedies and modern supplements). It prevents LSL cholesterol oxidation and helps the body cope with allergens and other lung and breathing problems.
Clinical studies show that quercetin’s main points of absorption in the body appear to be in the small intestine – about 50%. The rest – at least 47% is metabolized by the colonic micro flora – the beneficial bacteria such as Lactobacillus acidophilus and Bifidobacterium longum. You may consider adding these beneficial bacteria (found in yogurt) either through the diet or a supplemental form.
Ellagic Acid is a component of ellagitannins – dietary polyphenols with antioxidant (and possibly anticancer) properties. Polyphenols are the basic building blocks of many plant-based antioxidants. More complex phenolic compounds, such as flavonoids are created from these molecules.
Ellagic acid is found in many fruits and foods, namely raspberries, strawberries, pomegranates, and walnuts. Clinical studies suggest that ellagitannins and ellagic acid act as antioxidants and anticarcinogens in the gastrointestinal tract.
Ellagitannins are durable antioxidants, and happily, they do not appear to be diminished by processing, like freezing. This means the benefits are still strong, even in frozen packs of raspberries or strawberries, or some of the better multi-ingredient supplement drink mixes.
In scientific studies, ellagic acid also showed an anti-proliferative effect on cancer cells, decreasing their ATP (adenosine triphosphate) production. ATP is the molecule that provides the primary energy source for the cells in our bodies. In a sense, ellagic acid seems to deprive cancer cells of their fuel.
Beta-Carotene: Probably the best-known of the carotenoids, beta-carotene is converted by the body into vitamin A. Many vegetables, especially orange and yellow varieties, are rich in this nutrient. Think summer squash, yams and of course, carrots.
Beta-carotene has long been associated with better eyesight, but it has other benefits, too. In a scientific study, beta-carotene decreased cholesterol levels in the liver by 44% and reduces liver triglycerides by 40%.
Lycopene is a carotenoid mostly found in tomatoes, but also in smaller amounts in watermelon and other fruits. Clinical studies have shown that lycopene consumption may decrease the risk of prostate cancer. In fact, high intakes of lycopene are associated with a 30% to 40% reduced risk. And, as good as beta-carotene is, its cousin, lycopene, seems to be an even stronger nutrient, protecting not just against prostate cancer, but heart disease as well.
Lutein is found in many fruits and vegetables, including blueberries and members of the squash family. Lutein is important for healthy eyes, and in fact it is found in high concentrations naturally in the macular region of the retina – where we see fine detail. It is one of the only carotenoids, along with its close sibling zeaxanthin, that is found in the macula and lens of the eye.
Lutein also supports your heart, too. In a scientific study, lutein reduced atherosclerotic lesion size by 43%. In other words, high intakes of lutein may actually help prevent coronary artery disease!
Interestingly, as is the case with lycopene, cooking or processing foods with lutein may actually make it more easily absorbed.
In clinical studies, men with high intakes of lutein (and its close cousin, zeaxanthin, found in broccoli and spinach) had a 19% lower risk of cataract, and women had a 22% decreased risk, compared to those whose lutein intakes were much lower.
Vitamin C: One of the best-known nutrients out there, vitamin C keeps our immune system strong; speeds wound healing, and promote strong muscles and joints. A free-radical fighter, vitamin C prevents oxidative damage to tissues, builds strength in collagen and connective tissue, and even reduces joint pain.
Sources of vitamin C are scattered throughout the spectrum of fruits and vegetables.
Potassium: Most Americans are deficient in potassium. For the most part, it’s hard to get too much of this valuable mineral. Potassium does great things for our hearts. Higher intakes of dietary potassium from fruits and vegetables have been found in clinical research to lower blood pressure in only 4 weeks.
Many researchers believe that the typical American diet has led to a state of chronic, low-grade acidosis – too much acid in the body. Potassium helps change pH balance to a more alkaline environment in the body and increases bone density.
This was proven in the long-running Framingham Heart Study which showed that dietary potassium, (along with magnesium and fruit and vegetable intake) provided greater bone density in older individuals.
Fiber is another food component many just don’t get enough of – especially if they’re eating a “typical American diet.” Fruits, vegetables and whole grains are excellent sources of fiber. However, fiber from a good fruits and vegetable drink mix should be derived from inulin and chicory root. This soluble fiber source not only adds to the overall amount of fiber you need (25 to 38 grams a day), but also provides a nice “nesting ground” for the beneficial bacteria that populate the intestines. And, even though some fiber has a bad rap for inhibiting mineral absorption, inulin and chicory root are “bone building” fibers – they actually help the body absorb calcium.
Flavonoids are an overarching term that encompasses flavonols, anthocyanidins, and flavones, isoflavones, proanthocyanidins, Quercetin and more. They are almost everywhere: in fruits, vegetables, grains, herbs, nuts and seeds – even in the coffee, wine and tea we drink. Flavonoids are responsible for the colors in the skins of fruits and the leaves of trees and other plants.
Flavonoids have many health benefits. They can help stop the growth of tumor cells and are potent antioxidants. Additionally, flavonoids have also been studied for their ability to reduce inflammation.
Anthocyanins: High on the list of important “visible” nutrients are anthocyanins. They color fruits and vegetables blue and red.
Anthocyanins are members of this extended family of nutmeats, the flavonoids. Typically found in high amounts in berries, anthocyanins are readily absorbed in the stomach and small intestine.
As antioxidants, anthocyanins dive deep into cell membranes, protecting them from damage. IT may be one reason why the anthocyanins from blueberries are considered such an important component in battling neuronal decline, like Alzheimer’s. Blackberries, raspberries, and strawberries are also excellent sources of this flavonoids group.
SDG lignans, (short for secoisolariciresinol diglucoside) are polyphenolic components of flaxseed, pumpkin and other herbal sources. Much of the recent research surrounding lignans has focused on flaxseed. In scientific and clinical studies, lignans from flaxseed support hormonal balance and may have cancer-preventing abilities. In fact, in one study, flaxseed lignans reduced metastatic lung tumor by 82% compared to controls.
The lignans in pumpkin seed, also considered a major source, target 5-alpha reductase activity.
This enzyme catalyzes the conversion of testosterone into the more potent dihydrotestosterone (DHT). DHT, like testosterone, is a steroid hormone or androgen. Androgens are responsible for the development and maintenance of masculine sex characteristics in both men and women. Excess levels of DHT can cause serious problems with prostate or bladder health. That’s why modulation of the 5-alpha reductase enzyme is so important – it helps maintain healthy testosterone and DHT levels. By balancing the levels of these key hormones, pumpkin seed lignans provide protection for prostate and bladder cells.
In addition, pumpkin seed has been shown to modulate the enzyme aromatase. Aromatase is present in the estrogen-producing cells of the adrenal glands, ovaries, testicles, adipose tissue, and brain. Aromatase converts testosterone, an androgen, into estradiol, and estrogen.
Inhibition of the aromatase conversion can help maintain a balance of healthy testosterone levels in women, which has been shown to strengthen pelvic muscles and reduce incidence of incontinence.
In fact, a clinical study, involving a pumpkin extract in conjunction with soy, resulted in significant support for bladder health. After two weeks of supplementation, 23 of the 39 postmenopausal women enrolled in the study showed great improvement in urinary frequency and sleep. By the end of the six week study, 74.4 percent of participants found pumpkin extract safely and significantly improved “nocturnia,” that is, the need to urinate frequently at night. For individuals with 2 to 4 episodes of nocturnia prior to the stud, and 81.8% improvement was seen – also showing great improvement in sleep quality. After all, if you don’t have to wake up every couple of hours to go to the bathroom you’re bound to get better sleep.
Beta glucan: Mushrooms are intense immune-boosting powerhouses due to their beta-glucan content. Three well-studied power-house mushrooms that contribute beta glucan to the diet include maitake, reishi and shiitake.
The most significant constituents of mushrooms are long chain polysaccharides (molecules formed from many sugar units) known as beta-glucan. These huge molecules act as immunoregualtors in the human body, helping to stabilize and balance the immune system.
This includes specific support of white blood cells, or lymphocytes, the primary cells of the immune system. Lymphocytes fall broadly into three categories: T cells, B cells, and natural killer (NK) cells.
In one clinical study, 165 patients with various types of advanced cancer were given maitake mushroom compounds alone or with chemotherapy. Cancer regression or significant symptom improvement was observed in 58% of liver cancer patients, and 62% of lung cancer patients. Plus, when maitake was taken in addition to chemotherapy, the immune cell activities were enhanced 1.2 to 1.4 times, compared with chemotherapy alone.
In another clinical study, researchers determined that Reishi increased the number of cancer killing white blood cells and made them more deadly to cancer cells.
And, in a scientific study of human breast cancer and myeloma cancer and myeloma cancer cell lines, shiitake compounds provided a 51% antiproliferative effect on the cells – inducing “apoptosis’ – the programmed cell death that should occur naturally.
While beta-glucan are distributed throughout the mushroom body, the beta-glucan concentrations are significantly higher in the mycelium – the interwoven fibers or filaments that make up the “feeding structure” of the mushroom.
Bioflavonoids are commonly found in bright yellow citrus fruits, including lemons, limes and oranges. They are responsible for the bright pigment found in the skin of the fruit, and are considered a “companion” to vitamin C, seeming to extend the value of the nutrient within the body.
Hesperidin is just one of the valuable bioflavonoids found in citrus. Hesperidin appears to lower cholesterol levels, as well as support joint collagen in examples of rheumatoid arthritis.
Epigallocatechin gallate (EGCG):
Polyphenols, most notably EGCG, or epigallocatechin gallate, are well-studied and powerful components of tea. EGCG has been shown to reduce colon and breast cancer risk. Green tea also boosts the immune system and encourages T-cell formation – part of the front-line defense of our bodies against sickness and disease.
Q. I’ve been seeing articles about fruits, vegetables and supplements touting “high ORAC value.” What does this mean?
ORAC is an acronym for Oxygen Radical Absorption Capacity, and is simply a measurement of antioxidant activity of nutrients. Oxygen radicals, or free radicals, are unstable molecules. They grab electrons from other cells to use for themselves, and in the process can damage them. It is believed that free radical activity plays a role in the development of many diseases such as heart disease and cancer, and also plays a role in aging.
Antioxidants help prevent this damage by “loaning out” extra electrons to stabilize free radicals/ Consider any fruit or vegetable with a high ORAC rating as having a lot of “antioxidant power.”
I know I should eat more fruits and vegetables, but it just seems so hard to get five servings a day.
The number one excuse I hear for not buying frits and veggies is that “fruits and vegetables are too expensive.” But are they really? Certainly, fresh foods that aren’t in season and have to be shipped a distance can be a bit pricey. If anyone added up how much spend on fast food, or prepackaged or processed snacks, it would probably be shocking.
Luckily, there are many ways to get your “Daily 5”. For instance, frozen fruits and veggies retain much of their nutrient profile. They can be an excellent alternative when certain foods are out of season. So too, are fruit and vegetable drink mixes – excellent supplemental sources of some of the nutrients our bodies need most.
More recently, the American
Of course, for people not accustomed to the fiber in fruits and veggies, there is some reason to think it’ll increase gas. When cell walls break down, and fiber passes through the system, it can create flatulence. Folks who eat fruits and vegetables every day generally don’t have this problem. Their systems are already accustomed to it.
For those just starting out on a better diet, however, start slowly – it helps your body adapt. Cooking vegetables can help, too, because it begins breaking down the cell walls early on.
One thing is certain, however. The “Typical American Diet” and good health are mutually exclusive. The increase in type 2 diabetes, heart disease, high cholesterol, and hypertension all point to the abuse our bodies suffer by eating diets high in fatty meats, processed sugars, and refined grains.
Q. Can I just drink fruit and vegetables drinks in place of 5 servings of fruits and vegetables?
Green drinks and fruit and vegetable drink mixes aren’t meant to replace whole foods, but they can be an excellent substitute when you’re rushed or traveling or just trying to fill everyday nutritional gaps. Their whole food ingredients absorb very easily and gently in the gut, and many of these drink mixes contain healthy doses of fiber, too.
Green drink mixes and food-based drink mixes combine many colorful fruits and vegetables and sometimes grasses in a healthy, mixable supplement assortment. While there have been many advancements in the field of green drinks, there are only a few that take the primary reason we eat into consideration: taste!
Happily, there are some companies out there with great-tasting drink mixes that also formulate based on the color concept, ensuring you get the broadest assortment of nutrients from a full range of fruit and vegetable colors to promote optimal health.
High-quality fruit and vegetable drink mixes offer the best from nature’s color wheel in a convenient and great-tasting supplement. So, the next tie you feel like taking a coffee break – try a fruit and veggie break instead. Your body and spirit will thank you.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1451) Enjoy Some Nuts Every Day
Date:
November 03, 2006 04:00 PM
Although high in fat, nuts contain oils that reduce the risk of coronary heart disease. Nuts also contain potentially cardio protective components including phytosterols, tocopherols and squalene. Walnuts, almonds, pecans, Brazil nuts and macadamia nuts were all found to be good sources of these compounds. Diets that included one or two servings of macadamia nuts a day have been shown in studies done in Brisbane Australia and Honolulu Hawaii to improve blood lipid profiles as effectively as low-fat, complex carbohydrate diets. Furthermore, scientists at the Harvard School of Public Health found that eating nuts and peanut butter reduced the risk of type II diabetes in women. The researchers suggest that nuts might replace refined grain products, and red or processed meats as a way to limit caloric intake. The Lowly Goober Gets New Respect Americans eat more peanuts and peanut butter than all other nuts combined. A Pennsylvania State University study of 13,000 men, women and children revealed that peanut eaters have higher intakes of several hard-to-get nutrients compared to those who did not consume peanuts. Peanut butter and peanut eaters have increased levels of vitamin A, vitamin E, folate, Calcium, magnesium, zinc, iron and phytonutrients resveratrol, beta sitosterol and p-courmaric acid. What’s more, peanut eaters also had leaner bodies than non peanut eaters. This study helps to dispel the myth that higher-fat foods automatically lead to weight gain. The peanut Butter Diet evolved from studies such as this that showed the benefits of eating peanuts and peanut butter, particularly their high satiety factor. In one small study, ten health workers aged fifty-plus, consumed 1500 calories healthy and moderate fat (35%) diet that included two tablespoons of peanut butter eaten twice a day. The woman had at least one cardiovascular risk factor – high blood pressure, altered blood lipids or diabetes. Peanut butter was chosen because previous studies at Harvard/Brigham Women’s hospital had shown that over an eighteen-month period, three times as many women stuck with a diet that included peanut butter or peanuts, because of a hunger curbing effects. Peanuts contain about 2 grams of fiber per tablespoon and when spread on two slices of whole-wheat bread, deliver six grams of fiber. Peanut butter makes some yummy sauces. The barbecued ribs a group of scientists and I prepared during a recent weekend at the Culinary Institute of America Greystone in California’s Napa Valley where the best I have ever eaten. Tropical Oils The term refers to coconut, palm kernel and palm oils. These oils contain a variety of fatty acids, but unlike olive, macadamia and peanut oils, which contain high levels of unsaturated fatty acids and are liquid at room temperature; tropical oils have high levels of saturated fats and are solid at room temperature. They are gaining popularity as food manufacturers push to replace hydrogenated oils that contain trans fats. The latest hoopla over coconut oil has been its inclusion in weight loss regimens. Two books featuring coconut products have hit bestseller lists. Moderate increase of tropical oils including coconut and palm appear to improve blood lipid profiles largely because of their high lauric acid content. The health benefits of medium chain triglycerides (MCTs) such as caprylic and lauric have been known for some time. Lauric acid has been found to improve blood lipids and red palm oil is rich in antioxidants such as beta-carotene and tocotrienols, the vitamin E active constituent. However, there is concern among some experts that eating to many saturated fats, including the tropical oils used to make trans fat free margarine and shortening, can have deleterious effects on cardiovascular health. In addition, there are differences in processing palm and palm kernel oils that make some choices unhealthy. According to Dr. Andrew Weil palm oil is a better choice than palm kernel oil because chemical solvents are needed to extract palm kernel oil while none are required to press the oil from palm fruit. Fractionation is used to process palm and palm kernel oil and eliminates many of their natural antioxidants, which makes them the least desirable of the tropical oils. It seems prudent to check ingredient labels for fractionated palm kernel oil and avoid it. Best of all, look for Now Organic Coconut Oil that has an impressive resume for boosting immunity. It also has a distinctive flavor to foods prepared with an eastern Indian theme.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1417) The sunshine vitamin can impart an all-over healthy glow.
Date:
September 18, 2006 03:42 PM
When papers like the Los Angeles Times write articles with titles like “wonder Pill-really” about a seemingly ho-hum nutrient like vitamin D, attention must be paid. The attention is now forthcoming from researchers who are exploring this humble vitamin’s connection to an astonishingly wide spectrum of health issues. And these scientist are concerned that, dispite fortification of such common foods as milk, many people aren’t getting the D they need for optimal well-being. Vitamin D generally recognized as calcium’s indispensable little helper, which makes it vital to maintaining bone health. But we now know that D’s benefits extend far beyond calcium control; it plays crucial roles in immunity, blood cell formation and hormone regulation. Anti-Cancer D-Fense Scientists believe that vitamin D helps cells differentiate, or mature into specialized roles each is meant to play. That’s important in cancer defense because malignant cells tend to be undifferentiated, primitive types given to reproducing uncontrollably. Cells, both malignant and healthy, have vitamin D receptors on their surface; when d binds to cancer cells, they stop growing. This may help explain why men with low levels of vitamin D are particularly prone to dying of cancer and why higher rates of prostate cancer occur in climates where exposure to the sun-which powers D creation within the skin—is low. On a more positive note, investigators at the Moores UCSD Cancer Center of San Diego report that taking 1,000IU of vitamin D daily appears to drop the risk of developing breast, colon and ovarian cancer by up to 50% (American Assn for Cancer Research, Ninth Meeting). Other studies suggest that even after cancer develops, D may help hinder disease progression and enhance survival. Vitamin D does a body good in a number of other ways. For example, the sunshine vitamin lights up both the immune system and production of insulin, the hormone that controls blood sugar. In one study women who took the amount of vitamin D generally found in multivitamins (400 IU) and had a 31% reduced fisk of dying from heart disease; in another, D from multivitamins dropped the risk of multiple sclerosis development by 40%. Supplements have also helped stroke victims avoid the muscular wasting that leaks to falls and fractures (Cerebrovascular Disease 7/05). Conversely, low D levels have been linked to poor lung function, unexplained muscle pain and increased obesity risk. Widespread D-ficiency Currently, the federal government recommends daily vitamin D intakes of 200IU for people under age 51, 400IU for those 51 – 70 and 600 IU for ages 71 and up. But many prominent scientists believe those levels are two low, especially since so many folks avoid sun exposure to cut skin cancer risk. “I’m 99% sure that vitamin D deficiency is becoming more common,” Harvard nutrition expert Dr. Walter Willett told the LA Times (06/12/06). Deficiencies are more likely among dark-colored individuals (whose skins do not make D effectively), vegans (who avoid dairy) and people with disorders that reduce intestinal absorption, such as Crohn’s disease. Higher dosages should always be taken under practitioner’s watchful eye, especially if a medical condition already exists. No matter what health hazard you’re trying to illuminate, don’t hesitate to bask in the sunshine vitamin’s warm radiance. –Lisa James.
Also available: Solaray Vitamins and Now Vitamins
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1380) Review of Omega-3 Studies shows Heart Health Connection
Date:
August 03, 2006 02:53 PM
Review of Omega-3 Studies shows Heart Health Connection… A recent systematic review of studies on omega-3s from oily fish and supplements showed that the fatty acid may reduce the risk of cardiac and sudden death, and potentially stroke, Published in the American Journal of Clinical Nutrition (2006, Vol.84: 5-17), the review only considered studies that lasted longer than one year and that reported or estimated omega-3 intakes and cardiovascular (CVD) outcomes. Most trials reported that fish oil significantly reduced all-cause mortality, myocardial infraction, cardiac and sudden death, or stroke. Primary prevention of cardiovascular disease was reported in one randomized controlled trial, in 25 prospective cohort studies, and in seven case-control studies. The effects on stroke were inconsistent. Evidence suggests that increased consumption of omega-3s from fish or fish-oil supplements reduces the rates of all-cause mortality, cardiac and sudden death, and possibly stroke.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1338) Best Sugar Balance Svetol (green coffee extract)
Date:
May 05, 2006 06:30 PM
Ingredients Best Sugar Balance featuring Svetol® Svetol® is an extract of green coffee obtained by the use of a traditional patented extraction process from the beans of the species Coffea canephora robusta Pierre. This species is particularly rich in the constituent known as chlorogenic acid. Svetol® green coffee extract contains less than 2% caffeine. The extract is standardized to contain between 45-50% chlorogenic acids. In vitro (test tube) and in vivo research suggests that chlorogenic acids present in coffee may have the ability to regulate blood sugar concentrations after meals by acting on the intestinal absorption of glucose and improving the body's glucose tolerance. Clinical evidence also suggests that Svetol® green coffee extract may help to maintain a healthy blood sugar level when used as a part of the diet.* Benefits Maintains healthy blood sugar levels when used as a part of the diet* CHLOROGENIC ACIDS Chlorogenic acid is the major polyphenol compound found in Svetol® green coffee bean extract. In vitro and animal studies have been conducted to determine the potential actions of this polyphenol. Studies report that chlorogenic acid and related compounds have significant antioxidant potential and are responsible for the high reported antioxidant benefit of green coffee. Several studies suggest that consumption of coffee in the diet is one factor that is correlated to the maintenance of healthy neural function and healthy aging. Coffee has also been shown in vitro to suppress the production of various free radicals. The chlorogenic acid content of coffee has been determined to be a major factor in the free radical quenching properties of coffee. A study was conducted to assess the activity of coffee extracts against the production of hydroxyl radicals in an in vitro system. It was found that coffee extracts possessed significant suppressive activity against hydroxyl radicals. Of the compounds assumed to be responsible for this effect, the researchers concluded that the chlorogenic acids played a major role with some contributions from other compounds found in the extract. This compound may also strongly contribute to any potential neuroprotective effects seen with coffee consumption.1 Two further studies highlight a possible mechanism by which chlorogenic acid mediates its antioxidant activity. In one study, the FRAP (Ferric Reducing Antioxidant Power) assay was used to measure and compare the iron-reducing capacity of chlorogenic acid and caffeine. It was shown that the chlorogenic acid content of the samples tested was highly correlated with iron-reducing activity in this assay. Moreover, lighter roasted coffee samples (closer in nature to green coffee) had the highest iron-reducing activity. Caffeine did not influence the iron-reducing activity of the coffee samples.2 Iron compounds are known to mediate the production of radicals and often serve as catalysts for their production in the body. A second study shows that chlorogenic acid can bind to and Chelate certain iron compounds, preventing them from catalyzing radical-producing reactions. In this way, chlorogenic acid acts as a powerful antioxidant.3 Chlorogenic acid and related compounds have a dual effect on the production and suppression of free radicals. In the case of the hydroxyl radical, studies outlined previously suggest that chlorogenic acid suppresses the production of the radical due to its ability to chelate iron compounds, while other studies suggest that chlorogenic acid has direct scavenging effects on the hydroxyl radical.4 Dietary intake of this potent polyphenol may confer multiple benefits to human health. Several studies further suggest that chlorogenic acid in coffee can have a beneficial effect on blood sugar levels when consumed as a part of the diet. A recent study assessed the effects of coffee and tea consumption on glucose tolerance in middle-aged Japanese men. In this study, the relationship between daily intakes of green tea or coffee and glucose tolerance status was measured by the oral glucose tolerance test (OGTT). More than 3,400 men participated in the study in which fasting glucose was measured before and 2 hours after administration of an oral glucose load. A self-administered questionnaire was used to establish daily levels of dietary coffee and green tea consumption over the past year. The results showed that those individuals who consumed the highest levels of coffee per day had lower fasting glucose levels (by 1.5%) and lower post-test glucose concentrations (4.3% lower) than those who did not consume coffee Chlorogenic acid and related compounds have a dual effect on the production and suppression of free radicals. In the case of the hydroxyl radical, studies outlined previously suggest that chlorogenic acid suppresses the production of the radical due to its ability to chelate iron compounds, while other studies suggest that chlorogenic acid has direct scavenging effects on the hydroxyl radical.4 Dietary intake of this potent polyphenol may confer multiple benefits to human health. Several studies further suggest that chlorogenic acid in coffee can have a beneficial effect on blood sugar levels when consumed as a part of the diet. A recent study assessed the effects of coffee and tea consumption on glucose tolerance in middle-aged Japanese men. In this study, the relationship between daily intakes of green tea or coffee and glucose tolerance status was measured by the oral glucose tolerance test (OGTT). More than 3,400 men participated in the study in which fasting glucose was measured before and 2 hours after administration of an oral glucose load. A self-administered questionnaire was used to establish daily levels of dietary coffee and green tea consumption over the past year. The results showed that those individuals who consumed the highest levels of coffee per day had lower fasting glucose levels (by 1.5%) and lower post-test glucose concentrations (4.3% lower) than those who did not consume coffee on a daily basis. In this study, green tea consumption was not associated with any benefits on glucose concentrations.5 It is likely that the chlorogenic acid found in coffee plays a role in supporting healthy glucose metabolism, whereas the role of caffeine is not clear, with some reports suggesting an adverse effect on sugar metabolism. A second study further confirms an effect of chlorogenic acid at inhibiting the absorption of glucose from the diet. This effect occurs in the small intestine. In this study, nine healthy fasted volunteers consumed 25 grams of glucose in 400 ml of water (the control group), caffeinated coffee, or decaffeinated coffee. Frequent blood samples were taken over the next 3 hours. It was found that glucose and insulin concentrations were higher 30 minutes after the consumption of caffeinated coffee than with either decaffeinated coffee or control (water).While caffeine has specific biological effects on raising glucose levels and impacting insulin profiles, chlorogenic acid was shown to have an antagonistic effect on glucose transport. Previous studies have also shown that chlorogenic acid significantly delays glucose uptake from the small intestine.6 RESEARCH ON SVETOL® Svetol® is a unique extract of Coffea canephora robusta green coffee beans containing between 45 and 50% chlorogenic acids with less than 2% total caffeine concentration. As outlined above, many studies highlight the potential benefits of coffee compounds, including chlorogenic acid, for providing protection against free radicals and promoting healthy glucose metabolism. A number of other potential benefits have been discovered for these compounds. Svetol® has also been the subject of preliminary clinical studies that have shown exciting results. In a pilot study, the effect of Svetol® on sugar concentrations after meals was evaluated in 15 individuals. In the same trial, the longer-term effects of Svetol® on weight management were also evaluated. Blood sugar concentrations were measured on two separate occasions. Patients were administered an oral glucose tolerance test (OGTT) in which they consumed a standard amount of sugar and had their blood sugar levels measured 1 hour after sugar intake. The first measurement was made on day 1 prior to taking Svetol® and the second OGTT was performed on day 2, after beginning the Svetol® regimen in which one tablet (200 mg per tablet) was administered 3 times during the day. Patients were fasted for at least 8 hours prior to the testing. The results showed that Svetol® was able to reduce blood sugar concentrations in 60% of the subjects. The mean reduction of blood sugar concentration in these individuals was 50%. The treatment was continued following the same regimen for 6 weeks to assess the impact of Svetol® on weight. The average weight loss of the participants was 1.5 kg (3.3 lbs) over the treatment period. 7 Based on the studies mentioned above and other related research on the ingredients in Svetol®, scientists have proposed two mechanisms of action whereby Svetol® may influence the metabolism and processing of glucose. The first mechanism seems to be an inhibitory action on glucose absorption from the diet. Svetol® may affect the uptake of glucose in the small intestine by modulating factors needed for sugar absorption. The second mechanism relates to possible effects of Svetol® in the liver's ability to produce glucose. Chlorogenic acids have been shown in vitro and in animal studies to modulate the effects of certain enzymes in the liver that catalyze the production of glucose. By having this dual effect on sugar absorption and sugar production, Svetol® is an effective product for maintaining healthy blood sugar levels when used as a part of the diet.* SAFETY Svetol® is a natural food extract from green coffee beans containing a standardized amount of chlorogenic acid. Studies have shown that chlorogenic acid (up to 500 mg/kg/day) given to pregnant rats from the 5th through 12th day of gestation caused no maternal or fetal mortality and no adverse effects on the nervous system. Chlorogenic acids have also been shown to be non-mutagenic in tests on bacteria such as the Ames test. The LD50 of chlorogenic acids has been determined to be higher than 2500 mg/kg body weight. Svetol® is also extremely low in caffeine, with less than 2% caffeine contained in the extract, and is not expected to have any of caffeine's stimulant effects. Svetol® is extremely safe with no adverse effects having been reported while taking Svetol® at the recommended dosage.7 *This statement has not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure or prevent any disease. Scientific References 1) Daglia M, Racchi M, Papetti A, Lanni C, Govoni S,Gazzani G. In vitro and ex vivo antihydroxyl radical activity of green and roasted coffee. J Agric Food Chem.2004 Mar 24;52(6):1700-4. 2) Moreira DP, Monteiro MC, Ribeiro-Alves M, Donangelo CM, Trugo LC. Contribution of chlorogenic acids to the iron-reducing activity of coffee beverages. J Agric Food Chem. 2005 Mar 9;53(5):1399-402. 3) Kono Y, Kashine S,Yoneyama T, Sakamoto Y, Matsui Y, Shibata H. Iron chelation by chlorogenic acid as a natural antioxidant. Biosci Biotechnol Biochem. 1998 Jan;62(1):22-7. 4) Zang LY, Cosma G, Gardner H, Castranova V, Vallyathan V. Effect of chlorogenic acid on hydroxyl radical. Mol Cell Biochem. 2003 May;247(1-2):205-10. 5) Yamaji T, Mizoue T, Tabata S, Ogawa S, Yamaguchi K, Shimizu E, Mineshita M, Kono S. Coffee consumption and glucose tolerance status in middle-aged Japanese men.Diabetologia. 2004 Dec;47(12):2145-51. Epub 2004 Dec 15. 6) Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr. 2003 Oct;78(4):728-33.
7) Berkem.Text on Svetol®.Gardonne, France: November 2005.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1258) Lutein to fight age-related macular degeneration!
Date:
February 27, 2006 05:53 PM
Lutein: The Antiordinary Antioxidant Lutein belongs to a class of compounds known as carotenoids. Carotenoids in general are yellow, orange, or red pigments responsible for many of the colors of the foods we consume each day. To date, over 600 carotenoids have been identified in nature, but are only produced by plants, algae and bacteria leaving humans and animals to consume carotenoids in the diet. Forty to fifty carotenoids are consumed in the typical US diet, but only 14 have been detected in the blood, indicating a selective use of specific carotenoids by the body. Lutein is one of these carotenoids found in the blood and has been increasingly associated with eye health over the last decade. Lutein’s role in eye health In the human eye, lutein is concentrated in the center of the retina in an area known as the macula. Lutein is deposited in the macula through the lutein we consume in out diet or through supplements. This area is responsible for human central vision and is colored intensely yellow due to high concentrations of lutein. Lutein is thought to be beneficial for eye health by reducing damage in the eye in two ways: 1) by absorbing blue light (blue light is thought to increase free radical formation in the eye) and 2) by acting as an antioxidant, reducing damage in the eye caused by free radicals. Leading carotenoid researchers believe these functions may lead to a reduced risk of age-related macular degeneration (AMD) and cataracts. Age-related macular degeneration Macular degeneration is the leading cause of blindness in the USA in those over 65. twenty-five and thirty million people are afflicted worldwide and currently there are no effective treatments for the disease. The disease has two forms known as dry and wet AMD. Ninety percent of AMD cases diagnosed are the dry form. In dry AMD, also referred to as early AMD, debris deposits under the center of the retina (known as the macula) interfering with its normal function. Parts of the macula atrophy, causing the central vision to slowly become dimmer or more blurry. Wet age-related macular degeneration, also known as late AMD, often develops in areas where dry AMD exists. Abnormal blood vessels grow and leak blood and fluid under the macula, causing scarring, which leads to rapid loss of central vision. Dr. Joanna Seddon published one of the first studies demonstrating a link between lutein intake and AMD risk in 1994 (1). This epidemiological study compared the risk of developing AMD to nutrient intake and showed a significant reduction in risk for developing AMD as lutein intake reached 6mg per day (57% reduction in risk). Since the Seddon study, researchers have shown that increasing dietary lutein intake raises blood levels of lutein as well as levels of lutein in the eye (2). Bone et al. demonstrated that eyes with higher levels of lutein were less likely to be afflicted with AMD (3). The latest clinical trial that investigated lutein’s role in AMD is known as the lutein antioxidant supplementation trial (L.A.S.T) (4). This study evaluated the effects of lutein supplementation for one year in 90 veterans diagnosed with dry AMD. Supplementation with lutein in these subjects significantly increased the concentration of lutein in the macula. Improvements in visual function were also detected with lutein supplementation. Glare recovery, visual acuity, and contrast sensitivity were all improved. This study continues to build on clinical evidence that the dry form of AMD may be responsive to changes in nutrition. Cataracts A cataract is a natural clouding of the lens, the area of the eye responsible for focusing light and producing clear, sharp images. For most people, cataracts are a natural result of aging. Currently in the US, cataracts are the second leading cause of blindness in the elderly behind AMD. Lutein is the major carotenoid that has been identified in the human lens asn is thought to provide similar benefits to the leans that are seen in the retina. Two large epidemiological studies consisting of >70,000 women (age 45-71) and >30,000 men (age 45-75) compared the risk of cataract extraction to nutrient intake (5,6). Similar to AMD, a significant reduction in risk of cataract extraction was associated with lutein intakes of 6mg per day (20% reduction in risk). Besides cataract extraction, higher levels of lutein consumption have been associated with a decreased risk of cataract development and improvements in visual acuity and glare sensitivity in people with age-related cataracts. Lutein consumption The richest source of free lutein in the typical US diet are dark green leafy vegetables, with the highest concentration found in kale followed by spinach. The average daily lutein intake is low, average between 1-2 mg/day. Currently there is no recommendations of the dietary guidelines for Americans 2005 (9 servings of fruits and vegetables every day) you would consume between 4 and 8 mg of lutein a day (7). Epidemiological evidence, animal models, and clinical data have indicated levels of 6-10 mg a day may be necessary to realize the health benefits associated with lutein consumption. By continuing to increase our intake of lutein, we begin to ensure the optimal health of our eyes. References: Seddon et al. (1994) dietary carotenoids, vitamin a, c, and e, and advanced age-related macular degeneration. Eye disease case-control study group. JAMA. 272: 1413-20. Bone et al. (2000) Lutein and zeaxanthin in the eyes, serum and diet of human subjects. Exp. Eye Res. 71: 239-45. Bone et al. (2001) Macular pigment in donor eyes with and without AMD: a case-control study. Invest. Ophthalmal. Vis Sci. 42: 235-40. Richer et al. (2004) Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-relaged macular degeneration: the veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 75: 216-30. Brown et al. (1999) A prospective study of carotenoid intake and risk of cataract extraction in the US men. Am. J. Clin. Nutr. 70: 517-24. Chasen-Taber et al. (1999) A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am. J. Clin. Nutr. 70: 509-16 HHS/USDA. Dietary Guidelines for Americans 2005. //www.healthierus.Gov/dietaryguidelines/CDC. National health and nutrition examination survey data 2001-2002. //www.cdc.gov/nchs/about/major/nhanes/nhanes01-02.html Brandon lewis, Ph.D. is the applied research and Technical services manager at kemin health, L.C. in des moines, iowa. His responsibilities include the initiation and management of laboratory projects pertaining to the inclusion and analysis of kemin ingredients in vitamins and dietary supplements, as well as developing new applications and prototypes that include kemin ingredients. Prior to joining kemin, Brandon was enrolled at the university of Florida where he received his Ph.D. in Nutritional Science from the department of Food Science and Human Nutrition.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1235) OsteoBoron™ Fact Sheet
Date:
December 08, 2005 05:09 PM
OsteoBoron™ Fact SheetNeil E. Levin, CCN, DANLA 8/8/05LIKELY USERS: People looking for joint support; People looking for bone density support; People who want to normalize Vitamin D levels KEY INGREDIENTS: FruiteX-B™ STRUCTURE/FUNCTION CLAIMS: Boron is an important trace mineral for bone and joint health throughout life, as well as for the development and maintenance of healthy bone density. 1,2,4,6,8,9 NOW® OsteoBoron™ is a patented (US Patent # 5,962,049) complex of Boron and Fructose that is safe and more bioavailable than other forms of Boron. 3,7 NOW® OsteoBoron™ is a superior form of Boron that has been the subject of clinical studies demonstrating its efficacy in the support of healthy joints. 7,10 NOW® OsteoBoron™ has also been shown to be safer than other Boron supplements. 3,7 ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: FruiteX-B™ is a patented ingredient that contains boron in a form that is chemically identical to the natural plant forms of boron found in food (Calcium Fructoborate). In human and animal studies this patented form of boron, taken at an amount equal or equivalent to 6 mg. per day, improved bone ash (bone minerals) and Vitamin D status in Vitamin D deficient subjects. In human studies, measurements of joint discomfort were dramatically reduced when taking this dosage for about 2 months. The dose used in most of these studies was equivalent to 2 capsules a day of NOW® OsteoBoron™, a form that has been shown to be biologically more beneficial than other forms of boron.11 SERVING SIZE & HOW TO TAKE IT: One vegetarian capsule twice a day, preferably at separate meals. This dose can be doubled for people with more severe deficiencies, though a physician should normally be consulted in such cases. COMPLEMENTARY PRODUCTS: Vitamin D, Calcium, Magnesium, copper, Silica/silicon, natural sources of phytoestrogens (plant sourced), Ipriflavone, Bone Strength or Bone Calcium formulas CAUTIONS: None. SPECIFIC: Please note any supplements currently consumed which may also contain boron, such as multiple mineral or multiple vitamin formulas, and cut your serving size of NOW® OsteoBoron™ to compensate. People who eat a lot of produce, fruit and nuts may also get a substantial amount from their food and may want to reduce their servings of NOW® OsteoBoron™ accordingly. NOW® OsteoBoron™ is safer (has less toxicity) than boron citrate. Boron may buffer body levels of estrogen, so women at risk from high estrogen should consult a physician before using NOW® OsteoBoron™, even though this problem has not been noted for food source borons. GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time. Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. REFERENCES:
1. Shils ME, Olson JA, Shike M (eds.) (1994) Modern Nutrition in Health and Disease, Eighth Edition. Chapters 20-26, 28, 30. Lea & Febiger Philadelphia.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1001) Tru-E Bio Complex
Date:
December 08, 2005 04:58 PM
Tru-E Bio Complex TMNeil E. Levin, CCN, DANLA 7/27/05LIKELY USERS: Most Americans are deficient in Vitamin E 8,9,10; People needing superior antioxidant protection3,5,6; People needing cardiovascular or cholesterol support27,30,31; People needing nervous system support7; Those wanting healthier skin6; Diabetics may need additional Vitamin E24 KEY INGREDIENTS: Tocopherols from IP-Preserved, non-GMO Soy; Tocotrienols and tocopherols from non-GMO virgin palm; Tocotrienols from non-GMO annatto seed MAIN PRODUCT FEATURES: NOW Tru-E Bio ComplexTM is a unique biologically balanced, patent-pending formula designed to provide optimal Vitamin E activity. This product features 100% natural, Non-Genetically Modified sources of all 8 isomers (forms) of the Vitamin E “family” in ratios similar to what is found in a healthy diet. It provides the superior benefits of foodsource Vitamin E versus those obtained from traditional E supplements. NOW® Tru-E Bio ComplexTM has been carefully blended to supply high levels of the natural gamma and delta “desmethyl” forms of both tocopherols and tocotrienols. This is important because recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues. This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants. This science-based natural Vitamin E supplement is unlike any other and the first to combine all of these benefits in one convenient non-GMO formula! 25-32 Recent research indicates that these isomers work best as a team to quench the lipid and nitrogen free radicals known to cause injury to cells and tissues.1-4, 25-32 This product supports a healthy cardiovascular system, youthful skin and nervous system function with potent antioxidants.1,4-7 Levels of Vitamin E above 100 IU daily are associated with decreased risk of coronary heart disease and certain types of cellular disorders, as well as enhancement of immune function. These vitamin E intakes are considerably above levels obtainable from diet alone. 11,12,13 ADDITIONAL PRODUCT USE INFORMATION & QUALITY ISSUES: This is a product that is Patent Pending, based on months of research into optimal forms, potencies and ratios of the 8 isomers of natural Vitamin E. All of the Vitamin E formulas currently on the market use potencies of tocopherols that are very dissimilar to what is found in a healthy diet, with either too low or too high amounts of gamma and alpha tocopherols for a good balance. Some do not even include tocotrienols. All of the Vitamin E formulas on the market that do contain a mixture of tocopherols and tocotrienols tend to use either 400 IU or 100 IU of alpha tocopherol, some as little as 50-60 IU, combined with varying doses of gamma tocopherol. We have reduced the alpha tocopherol from the standard 400 IU per capsule to 200 IU, allowing more gamma tocopherol in the capsule to follow the typical ratio in a healthy diet. Other brands either cut the alpha tocopherol too low (to keep the gamma tocopherol at a good level) or else cut the gamma and other tocopherols too low (to keep the alpha tocopherol at 400 IU). Special care was used to maintain a certain ratio of tocopherols and of tocotrienols that is unique and from natural sources. Our formula is also unique in mixing sources of tocotrienols to achieve our desired balance, whereas other formulas include only one source, despite the dissimilarity of the mixture to what is found in a healthy, varied diet. Other formulas use either Vitamin E derived from genetically engineered soybeans and/or add soybean oil from similar sources as a base. NOW uses expensive non-GMO sources, the first formula to do so, with no soybean oil added. This enhances the quality of our product compared to every other formula on the market. We use the expensive virgin palm oil rather than the cheap palm distillates because it is un-denatured and contributes additional, valuable oil nutrients such as CoQ10, Squalene and Sterols. Also, much of the clinical research done on tocotrienols was done using virgin palm oil sources 32 Natural Vitamin E is more effective than synthetic Vitamin E.14 - 23 SERVING SIZE & HOW TO TAKE IT: One or two capsules per day, preferably with meal(s). Oils enhance the absorption of Vitamin E. Concentrated fiber supplements may decrease the absorption of Vitamin E, so it is best not to take both at the same meal. SYNERGISTS: Antioxidants (Alpha Lipoic Acid, Vitamin C Complex, Pine or Grapeseed Extracts, VitaBerry Plus+, CoQ10, etc.), Plant Sterols, Fish Oil, Flaxseed Oil, GliSODin, EGCg Green Tea Extract, Lecithin, Nuts and Seeds CAUTIONS: None. SPECIFIC: Aspirin and blood thinners should not be taken with Vitamin E without physician’s approval. Many other pharmaceutical drugs deplete Vitamin E, adding to the likelihood that a person will be deficient. GENERAL: Pregnant and lactating women and people using prescription drugs should consult their physician before taking any dietary supplement. This information is based on my own knowledge and references, and should not be used as diagnosis, prescription or as a specific product claim. This document has not been reviewed by the FDA or by the company posting it. Information given here may vary from what is shown on the product label because this represents my own professional experience and understanding of the science underlying the formula and ingredients. When taking any new formula, use common sense and cautiously increase to the full dose over time. REFERENCES:
1. Jiang Q, Christen S, Shigenaga MK, Ames BN (2001) g-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74:714-722.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=1000) Vitaberry Plus + Super Fruit Antioxidant
Date:
December 07, 2005 05:43 PM
Vitaberry Plus +™ Super Fruit AntioxidantBy Nilesh Patel, NOW Quality Assurance, April 20, 2005 Why are FRUITS AND VEGETABLES important? “Diets rich in FRUITS AND VEGETABLES may reduce the risk of some types of cancer and other chronic diseases.”- National Cancer Institute. OXYGEN AND ANTIOXIDANTS As we all know, “Oxygen is critical to life,” but is itself a double-edged sword. While oxygen is necessary to sustain life and for natural defense against microbes, too much oxygen in our cells can lead to the production of “free radicals” (mitochondrial respiratory chain) or ROS (Reactive Oxygen Species). Free radicals come in many forms - singlet oxygen, hydrogen peroxide, superoxideperoxynitrite, to name a few - but all have one commonality. Each has an unpaired (unbalanced) electron, a situation it remedies by stealing an electron from a stable molecule. This sets off a domino effect of oxidation, a chain reaction that usually ends up damaging cellular integrity and compromising overall health. Nature has a defense system in place to protect these processes in the form of antioxidants. Whether endogenous (produced by the body, such as liver enzymes, SOD, coenzymes and sulfur-containing compounds) or exogenous (obtained through the diet, such as vitamins C & E, bioflavonoids, carotenes, etc.), antioxidants “quench” free radicals by donating an electron to stabilize a molecule, thus controling the chain reaction and stopping the oxidation “domino effect”. ANTIOXIDANT-RICH FOODS Research suggests that eating plenty of foods high in antioxidants helps to slow the processes associated with aging and protect against many chronic diseases. Maximizing one’s antioxidant power will enhance overall health. Fruit and vegetables contain both nutritive and non-nutritive factors that can affect oxidative damage and enzymatic defense and might contribute to redox (antioxidant and prooxidant) actions. A new “6-a-day” study looked into the effects of fruits and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers by The Danish Institute for Food and Veterinary Research in Denmark. The study found that fruits and vegetables increase erythrocyte glutathione peroxidase activity and resistance of plasma lipoproteins to oxidation more efficiently than do the nutritive factors (vitamins and minerals) that the fruits and vegetables are also known to contain. Certain berries, such as blackberries, also contain salicylates, which are also linked to heart health and prevention of atherosclerosis. The protective effects of fruits and vegetables intake on both heart disease death and deaths in general have previously been demonstrated but researchers at the Human Nutrition Research Center on Aging at Tufts University, Boston. Quercetin is an anti-oxidizing flavonoid found in many berries (such as cranberries, bilberries, blueberries, strawberries, etc.) and can prevent CVDs (coronary vascular diseases), according to a recent Finnish study. All these natural plant polyphenols are responsible for the colors of many red and purple berries, fruits, vegetables and flowers. GOVERNMENT GUIDELINES The new federal guidelines released earlier this year by the U.S. Department of Health and Human Services (HHS) and U.S. Department of Agriculture (USDA) recommend eating more fruits and vegetables, combined, than any other food group -- five cups or about 10 servings a day for most adults. The amount of fruits and vegetables recommended has increased for men and women of every age. “Fruits and vegetables are the "good news" story of the new Dietary Guidelines for Americans for food-loving consumers, the industry and America's public health”, stated the Produce for Better Health Foundation (PBH). Eating a variety of colorful phytochemical-rich fruits and vegetables has been associated with lower risk of some chronic diseases such as cancer and heart disease. Many authoritative organizations such as the National Cancer Institute and The American Heart Association recommend getting phytochemicals from whole foods, such as fruits and vegetables, rather than from individual component supplements. The Scottish government is promoting healthy eating through a scheme designed to increase purchasing of fruit and nutritional foods. Scottish health minister Andy Kerr said, "This initiative shows that healthy eating can be good for customers and good for business." Scottish women are said to have the highest rates of death from lung cancer in the world as well as the highest rates in Europe for coronary heart disease. They also have low consumption of fruits and vegetables, shown in studies to help protect against some cancers and benefit heart health. ROS (Reactive Oxygen Species) Free radicals and oxygen free radicals play an important role in the development and progression of many brain disorders such as brain injury, neurodegenerative disease, and Down syndrome. Oxidative stress is an important factor in the etiology and pathogenesis of diabetes & is also linked to other host of degenerative health conditions. Fortunately, antioxidants are available to support the body’s defense and fight disease and aging. Examples of “Fast acting antioxidants” in the body (serum) are: uric acid (polyphenols), ascorbate, bilirubin, vitamin E (the later two are lipid soluble). Examples of “Slow acting antioxidants” are glucose, urea nitrogen etc. In short, free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated as by-products of normal cellular metabolism. Their deleterious effects are minimized in vivo (in the body) by the presence of antioxidant systems. How do Antioxidants work? Antioxidants are substances in plants that help maintain health. Antioxidants protect against damage to cells caused by too many “free oxygen radicals,” which form because of the effects of oxidation. Smoking, sunlight, heavy exercise, and pollution all increase oxidation in the body. Most people would benefit by eating more (five to nine or more servings) fruits and vegetables & colorful plant foods, such as purple, dark green, yellow, orange, blue, and red ones, each day. These have healthful pigments along with antioxidant nutrients such as vitamin C, carotenoids, beta-carotene, lycopene, lutein, zeaxanthin, vitamin E, selenium, flavonoids, and other beneficial substances. There are numerous ways in which these antioxidants affect, but can be explained in two groups: Alpha (a) Effects: This refers to the scavenging or neutralizing of free radicals. These effects do not change the way humans (or animals) feel. There are also no noticeable health, psychological or emotional benefits. While there are no obvious changes, increased total antioxidant intakes are associated with decreased tumor rates, prevention of heart attacks and increased longevity. Beta (ß) Effects: These are the changes on health, psychological or emotional state that you or others will notice. In this case, the antioxidant is affecting metabolic processes (enzymes) with consequent changes in the physical (improvement in joint movements, improved skin condition, tissue damage recovery), emotional (better ability to cope with stress) or psychological state (increased alertness). The ORAC value Because most of the active nutritional components in fruits and vegetables are antioxidants, accurate measurement of antioxidant activity serves as a good indicator of potential health benefit. Scientific opinion runs high that ORAC (Oxygen Radical Absorption Capacity) will eventually become a government standard of reference for overall daily fruits and vegetables intake. ORAC units are a measurement of the ability of food to stop oxidation. It is most generally expressed in terms of Trolox equivalent per gram (µmole Trolox equivalents (TE)/g). POPULATION DATA A survey done by the National Research Council indicates that only 10% of the US population consumes the recommended five servings of fruits and vegetables per day. The equivalent to eating 5 mixed servings of fruits and vegetables per day is about 1,670 ORAC units. Based on scientific evidence it is suggested that daily antioxidant intake should be increased to between 3,000 and 5,000 ORAC units per day, per human subject, in order to reach a significant antioxidant capacity in blood plasma and other tissues. WHAT IS NOW DOING TO HELP? In accord with our mission, “To provide value in products and services that empower people to lead healthier lives,” NOW® Foods is introducing an ALL-FRUIT-DERIVED antioxidant product called VitaBerry Plus +™ Super Fruit Antioxidant Vcaps (vegetarian capsules) (product number #3336). At time of manufacture this product provides an ORAC value of at least 2,500 units per serving from a full-spectrum antioxidant blend of fruits containing phytochemicals and phenolic compounds such as anthocyanins, proanthocyanins, chlorogenic acid, ellagic acid, quinic acid, resveratrol , many organic acids, resveratrol and vitamin C. VitaBerry Plus +™ is formulated with VitaBerry™ Hi-ORAC Fruit Blend [a proprietary blend of fruit extracts & concentrated powders containing Wild Blueberry (Vaccinium angustifolium) extract, Grape (Vitis vinifera) & Grape seed extract, Raspberry (Rubus idaeus) & Raspberry seed extract, Cranberry (Vaccinium macrocarpon), Prune (Prunus domestica), Tart Cherry (Prunus cerasus), Wild Bilberry (Vaccinium myrtillus) extract & Strawberry (Fragaria virginia)], Hi-Active™ Orange (Citrus sinensis) and Pomegranate (Punica granatum) min. 40% ellagic acid fruit extract. One gram of VitaBerry™ Hi-ORAC Fruit Blend provides at least 6,000 ORAC units (i.e., µmole Trolox equivalents (TE)/g). (Also watch for an upcoming antioxidant product from NOW called Enzogenol® (Pinus radiata bark extract from New Zealand) with Rutin (a flavonoid from South American fruit of Dimorphandra mollis) and Grapeseed extract. IS IT EFFECTIVE? Total ORAC value includes both lipophilic and hydrophilic components. VitaBerry Plus +™ contains only water/hydroethanol based extracts and concentrated (100:1 to 125:1) freeze-dried fresh fruit blends, so the lipophilic ORAC value is mere 2-4% of the total ORAC value. Glutathione peroxidase is a selenium-containing enzyme that decreases cell death from brain injuries. It also acts as a critical first-line antioxidant defense on the airway (respiratory) epithelial surface against ROS and RNS (reactive nitrogen species. Genetics research has found that the glutathione S-transferase gene controls the onset of Alzheimer’s, Parkinson’s disease etc. Taking glutathione (GSH) itself as a supplement does not boost cellular glutathione levels, since it breaks down in the digestive tract before it reaches the cells. So glutathione precursor dietary supplements (such as NAC and GliSODin), along with fruits and vegetables, are effective in boosting intracellular levels of GSH. The lungs have a defense system against the ROS oxidants consisting of low molecular weight antioxidants such as GSH and intracellular enzymes such as SOD, catalase and glutathione peroxidase to protect against the toxic effects of oxidants generated within the cells. Some of the primary effects of VitaBerry Plus +™ against the common reactive free-radical species or ROS are as follows: - Superoxide dismutase-SOD (destroys Superoxide radicals),- Catalase (neutralizes peroxides), - Functions similar to reduced Glutathione (GSH), - Glutathione peroxidase enzyme (detoxifies peroxides, using GSH as a reducing agent), - Functions similar to Glutathione S-transferase (GST), - Nullifies Superoxide-generating NADH/NADPH oxidase system In conclusion More concentrated than fresh berries, with over 6000 ORAC units per gram, VitaBerry Plus +™ provides consumers with the antioxidant power of almost 15 servings per day of FRUITS AND VEGETABLES ina convenient vegetarian capsule form! VitaBerry™ PLUS +™ (# 3336) provides a powerful, convenient way to supplement diets that do not include sufficient fruit and vegetable antioxidants Selected References: USDA/HHS guidelines report at: etaryguidelines/dga2005/document/
ls.com/proprietary/pdf/VitaberryBrochure.pdf g Kaplan M., Hayek T. , Raz A., Coleman R. and Aviram M. Pomegranate juice supplementation to apolipoprotein E deficient mice with extensive atherosclerosis reduces macrophages lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr. 131: 2082-2089 (2001) Lars O Dragsted et. al., The 6-a-day study:effects if fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. American Journal of Clinical Nutrition, Vol. 79, No. 6, 1060-1072, June 2004 Fuhrman B. and Aviram M. Polyphenols and flavaonoids protects LDL against atherogenic modifications.In: Handbook of Antioxidants Biochemical, Nutritional and Clinical Aspects, 2nd Edition. Cadenas E & Packer L (Eds.) Marcel Dekker, NY(Pub.). 16:303-336 (2001) Wood, Jacqueline, et al. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry 77 (2002) 155-161 Aviram M. Pomegranate juice as a major source for polyphenolic flavonoids and it is most potent antioxidant against LDL oxidation and atherosclerosis. Free Radical Research 36 (Supplement 1): 71-72 (2002) Jennifer Schraag, Antioxidants: Nature’s Way of Balancing Life. HSR Health Supplement Retailer, Vol. 11, No. 2, 24-27, February 2005 com/news/printNewsBis.asp?id=58665 com/news/printNewsBis.asp?id=58697
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=992) Chloride: The Forgotten Essential Mineral
Date:
November 20, 2005 07:54 AM
Chloride: The Forgotten Essential Mineral Chloride is an “essential” mineral for humans. It is abundant in ionic trace mineral preparations. It is a major mineral nutrient that occurs primarily in body fluids. Chloride is a prominent negatively charged ion of the blood, where it represents 70% of the body’s total negative ion content. On average, an adult human body contains approximately 115 grams of chloride, making up about 0.15% of total body weight.1 The suggested amount of chloride intake ranges from 750 to 900 milligrams per day, based on the fact that total obligatory loss of chloride in the average person is close to 530 milligrams per day. As the principle negatively charged ion in the body, chloride serves as one of the main electrolytes of the body. Chloride, in addition to potassium and sodium, assist in the conduction of electrical impulses when dissolved in bodily water. Potassium and sodium become positive ions as they lose an electron when dissolved and chloride becomes a negative ion as it gains an electron when dissolved. A positive ion is always accompanied by a negative ion, hence the close relationship between sodium, potassium and chloride. The electrolytes are distributed throughout all body fluids including the blood, lymph, and the fluid inside and outside cells.2 The negative charge of chloride balances against the positive charges of sodium and potassium ions in order to maintain serum osmolarity. Pivotal Roles of Chloride in the Body In addition to its functions as an electrolyte, chloride combines with hydrogen in the stomach to make hydrochloric acid, a powerful digestive enzyme that is responsible for the break down of proteins, absorption of other metallic minerals, and activation of intrinsic factor, which in turn absorbs vitamin B12. Chloride is specially transported into the gastric lumen, in exchange for another negatively charged electrolyte (bicarbonate), in order to maintain electrical neutrality across the stomach membrane. After utilization in hydrochloric acid, some chloride is reabsorbed by the intestine, back into the blood stream where it is required for maintenance of extracellular fluid volume. Chloride is both actively and passively absorbed by the body, depending on the current metabolic demands. A constant exchange of chloride and bicarbonate, between red blood cells and the plasma helps to govern the pH balance and transport of carbon dioxide, a waste product of respiration, from the body. With sodium and potassium, chloride works in the nervous system to aid in the transport of electrical impulses throughout the body, as movement of negatively charged chloride into the cell propagates the nervous electrical potential. Deficiency of Chloride Deficiency of chloride is rare. However, when it does occur, it results in a life threatening condition known as alkalosis, in which the blood becomes overly alkaline. A tedious balance between alkalinity and acidity is in constant flux, and must be vigilantly maintained throughout the entire body. Alkalosis may occur as a result of excessive loss of sodium, such as heavy sweating during endurance exercise, and in cases of prolonged vomiting and diarrhea. Symptoms include muscle weakness, loss of appetite, irritability, dehydration, and profound lethargy. Hypochloremia may result from water overload, wasting conditions, and extensive bodily burns with sequestration of extracellular fluids. In a situation in which infants were inadvertently fed chloride-deficient formula, many experienced failure to thrive, anorexia, and weakness in their first year of life.3 Excess Intake? Excessive intakes of dietary chloride only occur with the ingestion of large amounts of salt and potassium chloride. The toxic effects of such diets, such as fluid retention and high blood pressure, are attributed to the high sodium and potassium levels.4 Chloride toxicity has not been observed in humans except in the special case of impaired sodium chloride metabolism, e.g. in congestive heart failure.5 Healthy individuals can tolerate the intake of large quantities of chloride provided that there is a concomitant intake of fresh water. Other situations in which increased blood levels of chloride are seen include diseases of improper waste elimination that occur in kidney diseases. Excess chloride is normally excreted in the urine, sweat, and bowels. In fact, excess urinary excretion of chloride occurs in high salt diets. Excessive intakes of chloride can occur in a person with compromised health in addition to an unhealthy diet. However, those that follow a healthy diet and lead an active lifestyle may need to consider supplementing their diet with this important mineral. Chloride vs. Chlorine The mineral supplement chloride is very different from the gas chlorine. While elemental chlorine is a dangerous gas that does not exist in the free elemental state in nature because of its reactivity, although it is widely distributed in combination with other elements. Chloride is related to chlorine however, as one of the most common chlorine compounds is common salt, NaCl. Chloride is a by-product of the reaction between chlorine and an electrolyte, such as potassium, magnesium, or sodium, which are essential for human metabolism. Chloride salts are essential for sustaining human metabolism and have none of the effects of isolated chlorine gas. Sources of Chloride Chloride occurs naturally in foods at levels normally less than 0.36 milligrams per gram of food. The average intake of chloride during a salt-free diet is approximately 100 milligrams per day. Unfortunately, chloride is found commonly combined with undesirable dietary sources. The most common of these negative sources is table salt. Table salt is made from a combination of sodium and chloride ions. Other unhealthful sources include yeast extracts, processed lunchmeats, and cheeses. Healthier sources of chloride include kelp (seaweed), ionic trace minerals, olives, rye, tomatoes, lettuce, and celery, although not in large enough amounts to supply the needs of an active adult.6 In its original form, however, chloride is leached from various rocks into soil and water by years of weathering processes. The chloride ion is highly mobile and is transported to closed basins, such as the Great Salt Lake, or oceans.7 Summary Chloride is a highly important, vital mineral required for both human and animal life. Without chloride, the human body would be unable to maintain fluids in blood vessels, conduct nerve transmissions, move muscles, or maintain proper kidney function. As a major electrolyte mineral of the body, chloride performs many roles, and is rapidly excreted from the body. Active adults that eat a healthy diet devoid of salt and illnesses in which vomiting and/or diarrhea are profuse warrant the supplementation of additional chloride. Replacement of chloride is essential on a daily basis to maintain regular metabolic function. Chloride is safely utilized by the body, without negative health effects. Of the negative health effects that have been associated with diets high in chloride, these are mainly attributable to the accompanying sodium and potassium, two other electrolyte minerals to which chloride is often attached -------------------------------------------------------------------------------- 1 Wesson LG. Physiology of the human kidney. New York, NY, Grune and Stratton, 1969: 591 2 Weast RC, ed. CRC handbook of chemistry and physics, 67th ed. Boca Raton, FL, CRC Press, 1986. 3 Kaleita TA. Neurologic/behavioral syndrome associated with ingestion of chloride-deficient infant formula. Pediatrics 1986 Oct;78(4):714-5 4 Beard TC. A salt-hypertension hypothesis. J Cardiovasc Pharmacol 1990;16 Suppl 7:S35-8 5 Seelig M. Cardiovascular consequences of magnesium deficiency and loss: pathogenesis, prevalence and manifestations--magnesium and chloride loss in refractory potassium repletion. Am J Cardiol 1989 Apr 18;63(14):4G-21G 6 Altschul AM, Grommet JK. Food choices for lowering sodium intake. Hypertension 1982 Sep-Oct;4(5 Pt 2):III116-20 7 Gelb SB, Anderson MP. Sources of chloride and sulfate in ground water beneath an urbanized area in Southeastern Wisconsin (Report WIS01 NTIS). Chemical abstracts, 1981, 96(2):11366g.
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=958) Trace Minerals and Migraines
Date:
November 16, 2005 12:02 PM
Trace Minerals and Migraines An increasingly large amount of disease today may be attributable to deficiencies in the supply of trace minerals in our diets.1 How can this be the case when the availability of food in our country is unprecedented, with a supermarket on every corner? These deficiencies do not stem from a lack of quantity of food, rather they stem from the quality of food. Trace minerals can be found mainly in whole, unprocessed foods such as vegetables and fruits. Unfortunately, the large majority of fruits and vegetables found in supermarkets today are nutritionally devoid of these minerals, largely in part to the high-yield farming practices in this and other countries. The mineral content of food is mainly dependent on the amount of minerals found in the soil in which it is grown. Current farming practices leave soils with less than optimal amounts of these minerals, especially the less common trace minerals. As a result of this, our food supplies leave us at risk for deficiencies of these very important substances. Because of this situation, it is essential that every person now supplement their diet with trace minerals in order to avoid the many diseases that are attributable to this scarcity. A lack of vital nutrients leaves the body unable to function fully, leaving it vulnerable to disease. Trace minerals have numerous roles. Oftentimes, because these minerals are found in such small quantities in the body, scientists and physicians have paid little attention to their importance in health and disease prevention. However, with the advent of improved science and the recognition of the efficacy of natural medicine, we are beginning to understand how vital these elements are to our health. Trace minerals, in a sense, are akin to the numerous tiny nails, nuts, and bolts that hold a house together. At first glance, a home is made of much more than these items. However, if they are slowly removed and never replaced, the house will continue to sag and finally fall apart. So it is the same with the smallest building blocks of our bodies. Trace minerals are important in the proper functioning of enzyme systems, nerve conduction and muscle function, assisting with transfer of nourishment into cells, providing the framework for tissues, and regulation of organ functions. These ‘behind the scenes’ functions are not possible without a constant, adequate supply of minerals. Even with the many multivitamin and mineral supplements available, most of these products fall short because they do not contain large enough amounts of the trace minerals that are so important to health. Physicians that specialize in natural medicine are some of the biggest proponents of trace mineral supplementation. This type of physician is attuned to the many subtleties of the functions of the human body, and oftentimes addresses health issues with nutritional therapeutics in an attempt to bring the body’s health back into balance. This process of balance, also known as homeostasis, occurs quite wonderfully all by itself, as long as the body has the proper fuel and building materials. Unfortunately, physicians are seeing more and more diseases, which can be attributed to the body’s inability to achieve this balance. This trend towards ill health is directly related to the dearth of nutritional value in our diets today. However, practitioners of natural medicine are very excited with the many dramatic turn-arounds toward health that many of their patients have experienced with the use of mineral supplementation. A common example of this is the treatment of migraine headaches with magnesium. Recent statistics suggest that 18 percent of women and six percent of men suffer from migraine and those numbers are increasing.2 The Centers for Disease Control reported a 60-percent increase in the disease from 1980 to 1989.3 Migraine headaches occur when the blood vessels in the brain spasm and constrict. Soon after this constriction occurs, the blood vessels then reflexively open, or dilate. When the vessels become dilated, they occupy more space in the brain, activating nearby pain receptors. It is speculated that an imbalance of mineral stores in the body can lead to this spasm of the blood vessels. Many researchers have suggested magnesium plays an important role in migraine attacks. The activities of magnesium in the body include preventing blood vessel spasm, inhibiting blood clotting, and stabilizing cell membranes, all of which are involved in migraine develoment4. Magnesium concentration exerts an effect on neurotransmitter production and receptors, pro-inflammatory molecules, and other migraine-related chemicals in the brain.5 Recent evidence suggests up to 50 percent of migraine patients have lowered levels of tissue magnesium during an acute migraine attack.6 Another study discovered brain magnesium concentrations were 19 percent lower in patients during migraine attack compared to healthy controls.7 Because recent research strongly indicates a magnesium deficiency in migraine headaches, natural medicine practitioners prescribe magnesium along with other trace minerals as a primary treatment for this condition with great success. Because of their widespread distribution throughout the metabolic workings of the human body, trace minerals are integral to the functioning of one of the body’s largest organ systems, the muscles. Mainly, magnesium plays a large role in the relaxation of muscles following their contraction. Without this vital nutrient, it would be impossible for the muscles of the human body to function. Muscle cramps are prevalent in western society due to lack of intake of an appropriate amount of minerals. One easy, straightforward cure for muscle cramping is supplementation with magnesium and other trace minerals, as they allow the muscles to function smoothly and correctly. The role of magnesium in relieving cramped muscles also makes it a highly appropriate therapy for the muscle pain associated with fibromyalgia, a condition that is often treated successfully by practitioners of natural medicine. These practitioners often use high doses of magnesium and other trace mineral combinations to reduce the painful and tender muscles that are so common in fibromyalgia patients. Another condition that is successfully treated with magnesium and trace minerals is Chronic Fatigue Syndrome. People with this condition often experience profound muscle aches and weakness. It has been shown that in order for proper muscle contraction and relaxation to occur, magnesium and calcium need to be present in proper amounts in the body, which can be difficult to achieve even on a standard healthy diet. Additionally, magnesium and mineral supplementation may decrease the pain involved with sports-related injuries and excessive physical activity. As we use our muscular system, it is slowly depleted of these minerals, making replacement a top priority. Others signs of magnesium deficiency include disorientation, depression, tingling, numbness, seizures, abnormal heart rhythms in addition to muscle spasms and cramps.8,9 A minimum of at least 60 trace minerals has been demonstrated to be vital to health and well-being.10 This article has covered only a small fraction of the multitudes of health benefits of trace minerals. As science and natural medicine continues to uncover the many roles for all of these trace minerals, doctors are finding exciting solutions to several maladies that may be successfully treated by replacing these nutrients in the body. Unless we begin replacing these minerals early on in life, we put ourselves at risk for the many diseases of mineral deficiency that are becoming more and more prevalent in society today. References: -------------------------------------------------------------------------------- 1 Medical Nutrition from Marz, 2nd Edition. Omni-Press, 1997. Pps. 103-107 2 Stewart WF, Lipton RB, Celentano DD, et al. Prevalence of migraine headache in the United States: relation to age, income, race, and other sociodemographic factors. JAMA 1992;267:64-69. 3 Rappaport AM, Scheftell FD. Headache Disorders: A Management Guide for Practitioners. Philadelphia, PA: WB Saunders Co.;1996:4. 4 McCarty MF. Magnesium taurate and fish oil for prevention of migraine. Med Hypotheses 1996;47:461-466. 5Sinclair, S. Migraine Headaches: Nutritional, Botanical And Other Alternative Approaches. Alternative Medicine Review - Volume 4, Number 2, April 1999. 6 Mauskop A, Altura BM. Role of magnesium in the pathogenesis and treatment of migraine. Clin Neurosci 1998;5:24-27. 7 Ramadan NM, Halvorson H, Vande-Linde A, et al. Low brain magnesium in migraine. Headache 1989;29:590-593. 8 Rude RK. Magnesium deficiency: A cause of heterogeneous disease in humans. J Bone Miner Res 1998;13:749-58. 9 Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
10 Kelly, GS. Sports Nutrition: A Review of Selected Nutritional Supplements For Bodybuilders and Strength Athletes-Alternative Medicine Review - Volume 2, Number 3, May 1997
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=941) Optimizing Your Input
Date:
October 24, 2005 08:22 AM
Optimizing Your Input Multis are a good idea even if you eat a healthy diet. That’s because the government-defined Reference Daily Intake (RDIs) for various nutrients are based on preventing deficiency disorders, such as scurvy caused by a lack of vitamin C. But well-being depends less on avoiding deficiencies and more on getting enough nutrients to counteract the toxins, lack of sleep and high stress that modern flesh is heir to. That’s why multivitamins are often based on ODIs- Optimal Daily Intakes. While ODIs are not defined by any authoritative body, cutting-edge nutrition experts agree that they’re considerably higher than RDIs. Multivitamins also provide tailored nutrition for everyone in the family. For Dad, a men’s multi often contains extra vitamin E and zinc for peak prostate health, while Mom’s formulation might emphasize folate, iron and calcium. And Junior’s multivitamin should contain pint-sized amounts of everything a growing body needs, along with the kid-friendly flavor that ensures those nutrients actually get inside of Junior. (Athletic families take note: Your needs may be considerably different, so consult with a sports nutrition practitioner.)
(https://vitanetonline.com:443/forums/Index.cfm?CFApp=1&Message_ID=870) Nutrition Insurance ....
Date:
October 21, 2005 10:25 AM
All authorities agree that taking prenatal vitamins is a smart idea. Especially important nutrients include: -Folic Acid. This B vitamin helps prevent neural tube birth defects such as spina bifida, in which a malformed spinal cord can cause everything from fluid on the brain to paralysis. “The great news is that supplemental folic acid decreases the risk of neural tube defects pretty significantly,” says Higdon. “It’s recommended that women who are planning to become pregnant take a supplement that supplies 400 mcg.” Low folate is also associated with high levels of metabolic byproduct called homocysteine; it’s not clear whether high homocysteine is a symptom of folate deficiency or a cause of birth defects. To help folate control homocysteine, add vitamins B-6 and B-12 to your regimen, especially if you are a vegan.
-Iron. Iron deficiency is the most common micronutrient deficiency in the US, especially among women of childbearing age, and “has been associated with poor child development after birth along with increased risk of miscarriage and premature delivery,” according to Higdon. “Also, if you’re deficient you’ll get really tired-you get less oxygen delivered to your tissues an the baby’s” A supplement should supply 30mg; vegetarians have to pay particular attention to their iron levels. Eating foods rich in vitamin C can make it easier to absorb iron, as can eating such fermented soy goodies as tempeh and miso.
-Calcium. Building baby’s bones requires plenty of calcium; Jones and Hudson recommend getting 1200mg a day. If you are lactose intolerant-that is, you can’t properly digest milk products-they suggest you “try yogurt made with live active cultures, whose bacteria releases lactose-digesting enzymes.” Supplemental calcium is another option, preferably in gluconate or chelate form for better absorption. (Calcium can also help cut the leg cramps caused by the pressure of a growing baby.)
-Vitamin D. It doesn’t matter how much calcium you take if you’re not getting enough of the vitamin D that lets your body utilize calcium properly. “Vitamin D deficiency is increasingly common,” says Higdon, “and the RDIs (Reference Daily Intakes) might not be high enough for people who don’t get sun exposure.” Spending 15 minutes a day in the sun can restore your body’s supplies, but “the farther north you live, the longer that period in the winter you can’t make vitamin D, and it’s actually not in too many foods.” Taking 400 IU daily can make up the shortfall.
Believe it or not, iodine deficiency is a growing concern in the US as people cut back on salt, which is commonly fortified with iodine. Higdon says that most prenatal vitamins contain 150mcg.
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Date:
October 15, 2005 01:22 PM
Vitamin E for Prostate Health
Vitamin E - is a major antioxidant nutrient that helps maintain healthy membranes and retards cellular aging due to oxidation. It is especially important to sexual and reproductive health. One study that followed more than 29,000 male Finnish smokers, ages 50 to 69, for five to eight years, showed that Vitamin E reduces the risk of prostate cancer.
Our diets contain mostly the gamma tocopherol form of Vitamin E. Most dietary supplements contain only alpha tocopherol, not gamma tocopherol. Unfortunately, high intakes of alpha tocopherol actually pushes the preferred gamma form of Vitamin E out of the body. And since the most current research shows it is gamma tocopherol that is associated with a reduction of prostate cancer—especially when combined with selenium and alpha tocopherol—make sure you take a supplement that contains gamma and alpha, not just alpha tocopherol!
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Date:
October 13, 2005 04:45 PM
Benefits of Total Daily Formula
All fruits and vegetables contain carotenes, the plant pigments responsible for the rich variety of colors we enjoy in the natural world. Beta carotene is the most familiar member of the carotene family. But beta carotene never exists by itself; it is always found with other carotenes in foods. We need more than just beta carotene alone. Carotenes are powerful antioxidants, which means they help reduce the body's free radical burden. Research suggests that carotenes work as a team to keep us healthy.5 Total Daily Formula provides beta carotene, alpha carotene, lutein, lycopene, zeaxanthin and cryptoxanthin from natural sources such as algal extracts, carrot oil, marigold and tomatoes (Caromix®).
Total Daily Formula uses only corn-free vitamin C (ascorbic acid). The full daily intake of 6 tablets provides an exceptionally generous 800 mg of vitamin C.
Total Daily Formula supplies ample amounts of all essential B vitamins. Vitamin B3 is given as niacin plus an extra helping of niacinamide, the non-flush form of this important vitamin. The body uses pantothenic acid (vitamin B5) to deal with stress, so the formula provides 150 mg, which is 15 times the RDA. Vitamin B6 is another B vitamin people may run short of, so 60 mg -- 30 times the RDA -- is supplied. The formula contains 800 mcg of folic acid, the vitamin now recognized by the FDA as essential for prevention of neural tube defects in unborn babies. Folic acid also helps prevent accumulation in the body of homocysteine, a metabolite of the amino acid methionine.6 A high blood homocysteine level is now considered to be a risk factor for heart disease.7
Flavonoids, also known as "bioflavonoids." are plant pigments widely distributed throughout the plant kingdom.8 Previously known as "Vitamin P," because they help reduce capillary permeability (leakiness) flavonoids are now regarded as "semi-essential" non-vitamin nutrients that benefit health in a variety of ways.9 In addition to maintaining the structure of blood vessels, flavonoids function as versatile antioxidants. Flavonoids protect vitamin C from destruction by free-radicals, helping to preserve the body's vitamin C supply.10 Total Daily Formula provides 100 mg of pure flavonoids from 112 mg of citrus extract.
Three superior sources of Calcium
Total Daily Formula contains three of the best absorbed and most effective forms of calcium available. MCHC (microcrystalline hydroxyapatite concentrate) is a naturally-derived compound composed of calcium, plus all the minerals and organic factors in living bone tissue. MCHC has been clinically shown to benefit bone health.11 Calcium citrate malate is a very well-absorbed form of supplemental calcium shown in recent research to be helpful for postmenopausal women.12,13 Calcium glycinate is chelated with the amino acid glycine, one of the most efficient mineral carriers for effective absorption.14,15
Magnesium is essential for strong bones and healthy hearts. This versatile mineral also regulates nerve function, keeps muscles relaxed and coordinates activity of over 300 enzymes in the body.16 Total Daily Formula contains 100 percent magnesium glycinate for exceptional absorption and gentleness on the intestinal tract.17 Magnesium glycinate has been clinically tested on people with severe malabsorption with excellent results.18
Total Daily Formula provides - in addition to zinc, chromium, selenium and iodine - vanadium and molybdenum. Vanadium helps maintain normal blood sugar.19 Molybdenum works as a co-factor for enzymes that help detoxify and eliminate foreign substances from the body.20
Bioperine® for Enhanced Absorption
Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. 21 Betaine HCL - supplies HCL (hydrochloric acid) to assist digestion. All natural tablet coating made of vegetable concentrate and beta carotene.
Scientific References
2. Morgan, K.J. et. al. Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition. 1985;4:195-206.
3. Lakschmanan, F.L., Rao, R.B., Kim, W.W., Kelsay, J.L. Magnesium intakes, balances and blood levels of adults consuming self-selected diets. American Journal of Clinical Nutrition 1984;40:1380-89.
4. Mertz, W. The Essential Trace Elements. Fed. Proc. 1970;29:1482.
5. Perry, G. Byers, T. Dietary carotenes, vitamin C and vitamin E as protective antioxidants in human cancers. Annu. Rev. Nutr. 1992;12:139-59.
6. Landgren, F., et. al. Plasma homocysteine in acute myocardial infarction: Homocysteine-lowering effect of folic acid. J Int Med 1995;237:381-88.
7. Clarke, R., et. al. Hyperhomocysteinemia: an independent risk factor for vascular disease. New Eng J Med 1991;324:1149-55. 8. Havsteen, B. Flavonoids, a class of natural compounds of high pharmacological potency. Biochemical Pharmacology 32(7):1141-48.
9. Middleton, E. The flavonoids. TIPS 1984; 5:335-38.
10. Roger, C.R. The nutritional incidence of flavonoids: some physiological and metabolic considerations. Experientia 44(9):725-804.
11. Dixon, A. St. J. Non-hormonal treatment of osteoporosis. British Medical Journal 1983;286(6370):999-1000.
12. Smith, K.T. et. al. Calcium Absorption from a new calcium delivery system (CCM). Calcif Tissue Int 1987;41:351-352.
13. Dawson-Hughes, B. et. al. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. New England Journal of Medicine 1990 Sep 27;323(13):878-883.
14. Albion Research Notes Vol. 4, No. 1, ©Albion Laboratories Jan,1995.
15. Ashmead, H.D. Intestinal Absorption of Metal Ions and Chelate, Springfield: Charles C Thomas, ©1985.
16. Wester, P.O., Dyckner, T. The importance of the magnesium ion. Magnesium deficiency-symptomatology and occurrence. Acta Med Scand 1992; (Suppl) 661:3-4.
17. Albion Research Notes Vol. 3, No. 1, ©Albion Laboratories, Feb 1994.
18. Schutte, S., et. al. Bioavailability of Mg diglycinate vs MgO in patients with ileal resections. Abstract 115, AJCN 1992;56(4).
19. Cohen, N. et. al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J. Clin Invest 1995; 95:2501-09.
20. Sardesi, V.M. Molybdenum: An essential trace mineral element. Nutr Clin Pract 1993; 8:277-81.
21. Bioperine® - Nature's Bioavailability Enhancing Thermo-nutrient. Executive Summary' 1996; Sabinsa Corporation, Piscataway, N.J.
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Date:
October 06, 2005 10:08 PM
Magnesium is a dietary mineral with a wide array of biological activities in the body. Magnesium participates in numerous life-essential processes that occur both inside and outside cells. Magnesium deficiency impacts normal physiologic function on many levels. Adequate magnesium is a fundamental requirement for optimum function of the cardiovascular system, the nervous system and skeletal muscle, as well as the uterus and GI tract. Magnesium deficiency can affect health of the heart, bones and blood vessels and alter blood sugar balance [1].
Magnesium–Important for Everyone, Deficient in Many The average person living in a modern country today very likely consumes less than the optimum amount of magnesium [2]. An abundance of data collected over the last two decades shows a consistent pattern of low magnesium intake in the U.S. This pattern cuts a wide swath across various age-sex groups. The USDA’s Nationwide Food Consumption Survey found that a majority of Americans consumed less than the recommended daily magnesium intake [3]. Twelve age-sex groups were studied and this low magnesium intake was true for all groups except 0 to 5 year olds.
An analysis of the nutrient content of the diets of 7,810 individuals age four and above included magnesium among several nutrients where the amounts supplied by the average diet "were not sufficient to meet recommended standards" [4]. The FDA’s Total Diet study examined the intakes of eleven minerals, including magnesium, among eight age-sex groups. Data was collected four times yearly from 1982 to 1984. Levels of magnesium, calcium, iron, zinc and copper were low for most age-sex groups [5]. Surveys conducted in Europe and in other parts of North America paint a similar picture. Loss of magnesium during food processing is one explanation for this global lack of adequate dietary magnesium [6].
In particular, the elderly may be susceptible to magnesium deficiency for a variety of reasons, including inadequate magnesium intake, poor absorption due to impaired gastrointestinal function and use of drugs such as diuretics that deplete magnesium from the body [7]. It has recently been theorized that magnesium deficiency may contribute to accelerated aging, through effects on the cardiovascular and nervous systems, as well as muscles and the kidneys [8].
Women who take both synthetic estrogen and calcium supplements may be at risk for low blood levels of magnesium [9]. Estrogen promotes the transfer of magnesium from blood to soft–tissues. Low blood magnesium may result if the ratio of calcium to magnesium intake exceeds 4 to 1. Magnesium supplementation is thus advisable for women taking estrogen and calcium.
Young adults are not immune to magnesium deficiency. The University of California’s Bogalusa Heart Study collected nutritional data from a cross-sectional sample of 504 young adults between age 19 and 28 [10]. The reported intake of magnesium, along with several other minerals and vitamins, was below the RDA.
Glycine is a highly effective mineral chelator. This is because it is a low-molecular-weight amino acid, hence is easily transported across the intestinal membrane. A study conducted at Weber State University found this particular magnesium glycinate was absorbed up to four times more effectively than typical magnesium supplements.
Magnesium-the Versatile Mineral
The average adult body contains anywhere from about 21 to 28 grams of magnesium. Approximately 60 percent of the body’s magnesium supply is stored in bone. Soft tissue, such as skeletal muscle, contains 38%, leaving only about 1 to 2% of the total body magnesium content in blood plasma and red blood cells. Magnesium in the body may be bound either to proteins or "anions" (negatively charged substances.) About 55% of the body’s magnesium content is in the "ionic" form, which means it carries an electrical charge. Magnesium ions are "cations," ions that carry a positive charge. In its charged state, magnesium functions as one of the mineral "electrolytes."
Magnesium works as a "co-factor" for over 300 enzymatic reactions in the body. Metabolism uses a phosphate containing molecule called "ATP" as its energy source. Magnesium is required for all reactions involving ATP [11]. ATP supplies the energy for physical activity, by releasing energy stored in "phosphate bonds".
Skeletal and heart muscle use up large amounts of ATP. The energy for muscle contraction is released when one of ATP’s phosphate bonds is broken, in a reaction that produces ADP. Phosphate is added back to ADP, re-forming ATP. ATP also powers the cellular "calcium pump" which allows muscle cells to relax. Because it participates in these ATP-controlled processes, magnesium is vitally important for muscle contraction and relaxation. By controlling the flow of sodium, potassium and calcium in and out of cells, magnesium regulates the function of nerves as well as muscles [12].
Magnesium’s importance for heart health is widely recognized. The heart is the only muscle in the body that generates its own electrical impulses. Through its influence on the heart’s electrical conduction system, magnesium is essential for maintenance of a smooth, regular heartbeat [13]. Magnesium appears to help the heart resist the effects of systemic stress. Magnesium deficiency aggravates cardiac damage due to acute systemic stress (such as caused by infection or trauma), while magnesium supplementation protects the heart against stress [14]. This has been found true even in the absence of an actual magnesium deficit in the body.
Evidence suggests that magnesium may help support mineral bone density in elderly women. In a two-year open, controlled trial, 22 out of a group of 31 postmenopausal women who took daily magnesium supplements showed gains in bone density. A control group of 23 women who declined taking the supplements had decreases in bone density [15]. The dietary intakes of magnesium, potassium, fruit and vegetables are associated with increased bone density in elderly women and men [16]. In an interesting animal study, rats were fed diets with either high or low levels of magnesium. Compared to the high magnesium-fed rats, bone strength and magnesium content of bone decreased in the low-magnesium rats, even though these rats showed no visible signs of magnesium deficiency [17]. While this finding may or may not apply to humans, it raises the possibility that diets supplying low magnesium intakes may contribute to weakening of bone in the elderly.
Maximizing Absorption––Chelated Minerals Explained Mineral absorption occurs mainly in the small intestine. Like any mineral, magnesium may be absorbed as an "ion," a mineral in its elemental state that carries an electric charge. Mineral ions cross the intestinal membrane either through "active transport" by a protein carrier imbedded in the cells lining the membrane inner wall, or by simple diffusion. The magnesium in mineral salts is absorbed in ionic form. However, absorption of ionic minerals can be compromised by any number of factors, including: 1) Low solubility of the starting salt, which inhibits release of the mineral ion, and 2) Binding of the released ion to naturally occurring dietary factors such as phytates, fats and other minerals that form indigestible mineral complexes [18].
A second absorption mechanism has been discovered for minerals. Experiments have shown that minerals chemically bonded to amino acids (building blocks of protein) are absorbed differently from mineral ions. This has given rise to the introduction of "chelated" minerals as dietary supplements. Mineral amino acid chelates consist of a single atom of elemental mineral that is surrounded by two or more amino acid molecules in a stable, ring-like structure.
Unlike mineral salts, which must be digested by stomach acid before the desired mineral portion can be released and absorbed, mineral chelates are not broken down in the stomach or intestines. Instead, chelates cross the intestinal wall intact, carrying the mineral tightly bound and hidden within the amino acid ring. The mineral is then released into the bloodstream for use by the body. Research by pioneers in the field of mineral chelation and human nutrition indicates that the best-absorbed chelates consist of one mineral atom chelated with two amino acids. This form of chelate is called a "di-peptide." Compared to other chelates, di-peptides have the ideal chemical attributes for optimum absorption [19]. Dipeptide chelates demonstrate superior absorption compared to mineral salts. For example, a magnesium di-peptide chelate was shown to be four times better absorbed than magnesium oxide [20].
Consumer Alert! Not all "amino acid chelates" are true chelates. In order for a mineral supplement to qualify as a genuine chelate, it must be carefully processed to ensure the mineral is chemically bonded to the amino acids in a stable molecule with the right characteristics. The magnesium bis-glycinate/lysinate in High Absorption Magnesium is a genuine di-peptide chelate ("bis" means "two"). It has a molecular weight of 324 daltons, considerably lower than the upper limit of 800 daltons stated in the definition of "mineral amino acid chelates" adopted by the National Nutritional Foods Association in 1996 [21].
Bioperine® For Enhanced Absorption Bioperine® is a natural extract derived from black pepper that increases nutrient absorption.* Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine® [22].
Scientific References 1. Abbott, L.R., R., Clinical manifestations of magnesium deficiency. Miner electrolyte Metab, 1993. 19: p. 314-22. 2. Durlach, J., Recommended dietary amounts of magnesium: Mg RDA. Magnesium Research, 1989. 2(3): p. 195-202. 3. Morgan, K.e.a., Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition, 1985. 4: p. 195-206. 4. Windham, C., Wyse, B., Hurst, R. Hansen, R., Consistency of nutrient consumption patterns in the United States. J AM Diet Assoc, 1981. 78(6): p. 587-95. 5. Pennington, J., Mineral content of foods and total diets: the Selected Minerals in Food Survey, 1982 to 1984. J AM Diet Assoc, 1986. 86(7): p. 876-91. 6. Marier, J., Magnesium Content of the Food Supply in the Modern- Day World. Magnesium, 1986. 5: p. 1-8. 7. Costello, R., Moser-Veillon, P., A review of magnesium intake in the elderly. A cause for concern? Magnesium Research, 1992. 5(1): p. 61-67. 8. Durlach, J., et al., Magnesium status and aging: An update. Magnesium Research, 1997. 11(1): p. 25-42. 9. Seelig, M., Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnesium Research, 1990. 3(3): p. 197-215. 10. Zive, M., et al., Marginal vitamin and mineral intakes of young adults: the Bogalusa Heart Study. J Adolesc, 1996. 19(1): p. 39-47. 11. McLean, R., Magnesium and its therapeutic uses: A review. American Journal of Medicine, 1994. 96: p. 63-76. 12. Graber, T., Role of magnesium in health and disease. Comprehensive Therapy, 1987. 13(1): p. 29-35. 13. Sueta, C., Patterson, J., Adams, K., Antiarrhythmic action of pharmacological administration of magnesium in heart failure: A critical review of new data. Magnesium Research, 1995. 8(4): p. 389- 401. 14. Classen, H.-G., Systemic stress, magnesium status and cardiovascular damage. Magnesium, 1986. 5: p. 105-110. 15. Stendig-Lindberg, G., Tepper, R., Leichter, I., Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnesium Research, 1993. 6(2): p. 155-63. 16. Tucker, K., et al., Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr, 1999. 69(4): p. 727-736. 17. Heroux, O., Peter, D., Tanner, A., Effect of a chronic suboptimal intake of magnesium on magnesium and calcium content of bone and bone strength of the rat. Can J. Physiol. Pharmacol., 1975. 53: p. 304-310. 18. Pineda, O., Ashmead, H.D., Effectiveness of treatment of irondeficiency anemia in infants and young children with ferrous bisglycinate chelate. Nutrition, 2001. 17: p. 381-84. 19. Adibi, A., Intestinal transport of dipetides in man: Relative importance of hydrolysis and intact absorption. J Clin Invest, 1971. 50: p. 2266-75. 20. Ashmead, H.D., Graff, D., Ashmead, H., Intestinal Absorption of Metal Ions and Chelates. 1985, Springfield, Illinois: Charles C. Thomas. 21. NNFA definition of mineral amino acid chlelates, in NNFA Today. 1996. p. 15. 22. Bioperine-Nature's Bioavailability Enhancing Thermonutrient. 1996, Sabinsa Corporation: Piscataway, N.J.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Doctor's Best•1120 Calle Cordillera•Suite 101, San Clemente, CA 92673
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Date:
October 04, 2005 10:54 AM
The prevention of prostate cancer has been shown to be related to dietary intakes of some key nutrients, and several herbal extracts also can strongly influence prostate problems. It is important that herbal extracts and nutrients have the highest quality available and meet European pharmaceutical standards.
We looked hard and selected the following 10 items based on the following criteria:
1. Boron
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Date:
July 27, 2005 12:06 PM
Benefits
Helps maintain strong, healthy bones.*
In Vitro and Animal Studies
Strontium is a bone-seeking mineral incorporated by ionic substitution for calcium onto the crystal surface of bone.2 In the test-tube (in vitro), strontium inhibits the activity of osteoclasts, bone cells that break down bone, or “resorb” bone as part of the normal bone remodeling process.3 The effect of strontium, in the form of strontium ranelate (a salt of strontium and ranelic acid), was studied in monkeys over a six-month period. Strontium altered the remodeling of bone in the monkeys, resulting in decreased bone resorption with a concomitant maintenance of bone formation. A trend toward increased volume of osteoid, the organic matrix of bone, was observed, although this was not associated with defects in bone mineralization.4 In another animal study, monkeys fed strontium at high doses for six weeks showed a marked increase in bone strontium content. No harmful effects on bone mineral chemistry or structure occurred.5 At low doses, strontium has been shown to increase the number of bone forming sites in thighbones of adult rats, without adverse effects on the mineral content of bone or mineralization of the organic bone matrix.6 Strontium was shown to reverse bone loss induced by estrogen deficiency in rats.7
Clinical Trials
Human clinical trials have examined the effect of strontium on bone in postmenopausal women. In the dose-ranging (Phase 2) PREVOS trial, women in early menopause were administered strontium ranelate or a placebo for two years. Strontium ranelate was given at daily doses of 125 mg, 500 mg or 1 gram. (Total weight of compound; strontium plus ranelic acid). Compared to women in the placebo group, who lost bone, women on strontium at the 1 gram dose showed statistically significant increases in bone mineral density (BMD) of the hip, thigh and lumbar spine. Biochemical markers of bone formation, such as serum alkaline phosphatase, increased. No effect on markers of bone resorption was observed, leading to the conclusion that strontium ranelate, at the 1 gram daily dose, increased bone formation without decreasing bone resorption proportionally. It was concluded that 1 gram per day is the minimum effective daily dose of strontium ranelate in these women.8
In another Phase 2 trial (STRATOS trial), 353 postmenopausal women with osteoporosis, who had experienced at least one spinal fracture, took strontium ranelate for two years at daily doses of 500 mg, 1 gram or 2 grams. Women on the 2-gram dose showed a significantly greater increase in lumbar spine BMD than those on placebo. The number of subjects who had new spinal deformities was significantly reduced.9 As in the PREVOS trial, serum levels of alkaline phosphatase, a marker of bone formation, increased, while markers of bone resorption (breakdown) decreased. The overall conclusion is that the minimum effective daily dose of strontium ranelate (whole compound) is 1 gram in early postmenopausal non-osteoporotic women and 2 grams in postmenopausal women with osteoporosis.10
Phase 3 efficacy studies on strontium ranelate have been conducted on 1649 subjects in 12 countries. These studies began with an open-run (non-controlled study period in which subjects took calcium and vitamin D supplements to normalize their blood levels of these nutrients.11 Following this, two parallel groups were administered 2 grams daily of strontium ranelate or placebo for 3-years. The subjects continued to take calcium and vitamin D during the study. In subjects on strontium ranelate, BMD increased in the lumbar vertebrae by 14.4 percent and in the thighbone by 8.3 percent. The number and risk of vertebral fractures decreased.12
Safety
Suggested Use: Take two capsules daily. Calcium intake must also be adequate. Do not take this product with calcium supplements.
Strontium ranelate was well-tolerated in the trials discussed above. The incidence of adverse events in subjects on strontium ranelate was statistically equivalent to the placebo groups, and no negative effects on hematology and other biochemical parameters have been observed.
In view of the fact that subjects on the strontium trials also took calcium, and in some cases vitamin D, to maintain normal blood levels of these nutrients, it is important to ensure calcium and vitamin D intakes are adequate when supplementing with strontium. This is underscored by earlier research on animals suggesting that increasing the intake of strontium via diet may demineralize bone when calcium is deficient.13 In rats with chronic kidney failure, strontium has been shown to cause osteomalacia, a condition in which bone is softened due to lack of mineral content. For this reason, people on kidney dialysis should not use strontium supplements.14
Scientific References
1. Shorr E, Carter AC. The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis 1952; 13:59 -66.
2. Dahl SG, Allain P, Marie PJ, et al. Incorporation and distribution of strontium in bone. Bone 2001;28(4):446-53.
3. Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol 2002; 450:11-17.
4. Buehler J, Chappuis P, Saffar JL, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis) Bone 2001;29(2):176-79.
5. Boivin G, Deloffre P, Perrat B, et al. Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administration. J Bone Miner Res. 1996 Sep;11(9):1302-11.
6. Grynpas MD, Hamilton E, Cheung R, et al. Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 1996;18(3):253-9.
7. Marie PJ, Hott M, Modrowski D, et al. An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats. J Bone Miner Res 1993;8(5):607-15.
8. Reginster JY, Deroisy R, Dougados M, et al. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose ranging, placebo-controlled PREVOS trial. Osteoporosis Int 2002; 13:925-31.
9. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis––a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87(5):2060-66.
10. Reginster JY, Meunier PJ. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. Osteoporosis Int 2003; 14(Suppl 3):S56-S65.
11. Meunier PJ, Reginster JY. Design and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis. Osteoporosis Int 2003;14(Suppl 3):S66-76.
12. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350(5):459-68. 13. Grynpas MD, Marie PJ. Effects of strontium on bone quality and quantity in rats. Bone 1990;11:313-19.
14. Schrooten, I, Cabrera W, Goodman WG, et al. Strontium causes osteomalacia in chronic renal failure in rats. Kidney Int 1998;54:448-56.
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Date:
July 08, 2005 10:48 AM
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Date:
June 25, 2005 08:13 PM
REFERENCES
1 a. The Surgeon General’s “Nutrition and Health Report.” b. The Centers for Disease Control and Prevention’s “National Health and Examination Survey (NHANES III)” c. The National Academy of Science’s. Diet and Health Report: Health Promotion and Disease Objectives (DHHS Publication No. (PHS) 91-50213, Washington, DC: US Government Printing Office, 1990). e. Dietary Guidelines for Americans. 2 Rolls BJ. Carbohydrates, fats, and satiety. Am J Clin Nutr 1995; 61(4 Suppl):960S-967S. 3 McDowell MA, Briefel RR, Alaimo K, et al. Energy and macronutrient intakes of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1:1988-91. Advance data from vital and health statistics of the Centers for Disease Control and Prevention; No. 255. 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Dietetic influences on the formation and prevention of cholesterol gallstones. Z. Ernahrugswiss. 1994;33(1):2-15. 40 Cicuttini FM, Spector TD. Osteoarthritis in the aged. Epidemiological issues and optimal management. Drugs and Aging. 1995;6(5):409-20. 41 Melnyk MG, Wienstein E. Preventing obesity in black women by targeting adolescents: a literature review. J Am. Diet. Association. 1994;94(4):536-40. 42 Robinson BE, Gjerdingen Dk, Houge DR. Obesity: a move from traditional to more patient-oriented management. J. Am. Board of Family Practice. 1995;8(2):99-108. 43 Dulloo AG, Miller DS. Reversal of Obesity in the Genetically Obese fa/fa Zucker Rat with an Ehpedrine/Methylxanthines Thermogenic Mixture. J. Nutrition. 1987;117:383-9. 44 Dulloo AG, Miller DS. The thermogenic properties of ephedrin/methylxanthine mixtures: animal studies. Am J Clinical Nutr. 1986;43:388-394. 45 Richelsen B. Health risks of obesity. Significance of the regional distri-bution of adipose tissue. Ugeskr. 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Digestive Diseases. 1969;14(6) 60 Nauss JL , Thompson JL and Nagyvary J. The binding of micellar lipids to Chitosan. Lipids. 1983;18(10):714-19. 61 Braconnot H, Sue la natrue ces champignons. Ann Chim Phys 1811;79:265. 62 Odier A. Memoire sur la composition chemique des parties cornees des insectes. Mem Soc Hist Nat Paris 1823;1:29. 63 Johnson EL, Peniston QP. Utilization of shellfish waste for chitin and Chitosan production. Chp 19 In: Chemistry and Biochemistry of Marine Food Products. Martin RE, Flick GJ, Hebard CE and Ward DR (eds.) 1982. p.415-. AVI Publishing Co., Westport, CT. 64 Shahram H. Seafood waste: the potential for industrial use. Kem Kemi 1992;19(3),256-8. 65 Rouget C. Des substances amylacees dans le tissue des animux, specialement les Articules (Chitine). Compt Rend 1859;48:792. Commission on Natural Health Products. 1995 67 Peniston QP and Johnson EL. Method for Treating an Aqueous Medium with Chitosan and Derivatives of Chitin to Remove an Impurity. US Patent 3,533,940. Oct. 30:1970. 68 Poly-D-Glucosamine (Chitosan); Exemption from the Requirement of a Tolerance. Federal Register. 1995;60(75):19523-4. Rules and Regulations. Environmental Protection Agency 40 CFR Part 180. April, 19, 1995. 69 Arul J. “Use of Chitosan films to retard post-harvest spoilage of fruits and vegetables,” Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 70 Karlsen J, Skaugrud O. “Excipient properties of Chitosan,” Manufacturing Chemist. 1991;62:18-9. 71 Winterowd JG, Sandford PA. Chitin and Chitosan. In: Food Polysaccharides and their Applications. Ed: Stephen AM. Marcel Dekker 1995. 72 Chitin Workshop. ICNHP, North Carolina State University, Raleigh, NC. 73 Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 74 Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 75 Zikakis, JP. Chitin, Chitosan and Related Enzymes. Academic Press, Inc. 1984. 76 Abelin J and Lassus A. Fat binder as a weight reducer in patients with moderate obesity. ARS Medicina, Helsinki, Aug- October, 1994. 77 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Increasing effect of a Chitosan and ascorbic acid mixture on fecal dietary fat excretion. Biosci Biotech Biochem 1994;58(9):1617-20. 78 Maezaki Y, Tsuji K, Nakagawa Y, et al. Hypocholesterolemic effect of Chitosan in adult males. Biosci Biotchnol Biochem1993;57(9):1439-44. 79 Kobayashi T, Otsuka S, Yugari Y. Effect of Chitosan on serum and liver cholesterol levels in cholesterol-fed rats. Nutritional Rep. Int., 1979;19(3):327-34. 80 Sugano M, Fujikawa T, Hiratsuji Y, Hasegawa Y. Hypocholesterolemic effects of Chitosan in cholesterol-fed rats. Nutr Rep. Int. 1978;18(5):531-7. 81 Vahouny G, Satchanandam S, Cassidy M, Lightfoot F, Furda I. Comparative effects of Chitosan and cholestryramine on lymphatic absorption of lipids in the rat. Am J Clin Nutr, 1983;38(2):278-84 82 Suzuki S, Suzuki M, Katayama H. Chitin and Chitosan oligomers as hypolipemics and formulations containing them. Jpn. Kokai Tokkyo Koho JP 63 41,422 [88,422] 22 Feb1988. 83 Ikeda I, Tomari Y, Sugano M. Interrelated effects of dietary fiber on lymphatic cholesterol and triglyceride absorption in rats. J Nutr 1989;119(10):1383- 7. 84 LeHoux JG and Grondin F. Some effects of Chitosan on liver function in the rat. Endocrinology. 1993;132(3):1078-84. 85 Fradet G, Brister S, Mulder D, Lough J, Averbach BL. “Evaluation of Chitosan as a New Hemostatic Agent: In Vitro and In Vivo Experiments In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 86 Malette W, Quigley H, Gaines R, Johnson N, Rainer WG. Chitosan A New Hemostatic. Annals of Thorasic Surgery. 1983;36:55. 87 Malette W, Quigley H, Adickes ED. Chitosan effect in Vascular Surgery, Tissue Culture and Tissue Regeneration. In R Muzzarelli, C Jeuniaux, GW Gooday, Eds: Chitin in Nature and Technology. Plenum Press, New York. 1986. 88 Okamoto Y, Tomita T, Minami S, et al. Effects of Chitosan on experimental abscess with Staphylococcus aureus in dogs. J. Vet. Med., 1995;57(4):765-7. 89 Klokkevold PR, Lew DS, Ellis DG, Bertolami CN. Effect of Chitosan on lingual hemostasis in rabbits. Journal of Oral-Maxillofac-Surg, 1991;Aug. 49(8):858-63. 89 Surgery, Tissue Culture and Tissue Regeneration. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 90 Hiroshi S, Makoto K, Shoji A, Yoshikazu S. Antibacterial fiber blended with Chitosan. Sixth International Conference on Chitin and Chitosan. Sea Fisheries Institute, Gdynia, Poland. August 1994;16-19. 91 Shimai Y, Tsukuda K, Seino H. Antiacne preparations containing chitin, Chitosan or their partial degradation products. Jpn. Kikai Tokkyo Koho JP 04,288,017 [92,288,017] 13 Oct 1992. 92 Suzuki K, Okawa Y, Suzuki S, Suzuki M. Candidacidal effect of peritoneal exudate cells in mice administered with chitin or Chitosan: the role of serine protease in the mechanism of oxygen-independent candidacidal effect. Microbiol Immunol. 1987;31(4):375-9. 93 Sawada G, Akaha Y, Naito H, Fujita M. Synergistic food preservatives containing organic acids, Chitosan and citrus seed extracts. Jpn, Kokai Kokkyo Koho JP 04 27,373 [92 27,373] 30 Jan 1992. 94 Min H-K, Hatai K, Bai S. Some inhibitory effects of Chitosan on fishpathogenic oomycete, Saprolegnia parasitic. Gyobyo Kenkyu, 1994;29(2):73-4. 95 Nelson JL, Alexander JW, Gianotti L, Chalk CL, Pyles T. The influence of dietary fiber on microbial growth in vitro and bacterial translocation after burn injury in mice. Nutr 1994;10(1):32-6. 96 Ochiai Y, Kanazawa Y. Chitosan as virucide. Jpn Kokai Tokkyo Koho 79 41,326. 97 Hillyard IW, Doczi J, Kiernan. Antacid and antiulcer properties of the polysaccharide Chitosan in the rat. Proc Soc Expl Biol Med 1964; 115:1108-1112. 98 Shibasaki K, Sano H, MatsukuboT, Takaesu Y. pH response of human dental plaque to chewing gum supplemented with low molecular Chitosan. Bull- Tokyo-Dent-Coll, 1994:35(2): 61-6. 99 Kato H, Okuda H. Chitosan as antihypertensive. Jpn. Kikoi Tokyo Koho JP 06 56,674 [94 56,674] 100 Kato H, Taguchi T. Mechanism of the rise in blood pressure by sodium chloride and decrease effect of Chitosan on blood pressure. Baiosaiensu to Indasutori 1993;51(12):987-8. 101 Muzzarelli R, Biagini G, Pugnaoni A, Filippini O, Baldassarre V, Castaldini C, and Rizzoli C. Reconstruction of Periodontal Tissue with Chitosan. Biomaterials. 1989;10:598-603. 102 Sapelli P, Baldassarre V, Muzzarelli R, Emanuelli M. Chitosan in Dentistry. In Chitin in Nature and Technology. Eds: R Muzzarelli, C Jeuniaux, GW Gooday. Plenum Press, New York. 1986. 103 Borah G, Scott G, Wortham K. Bone induction by Chitosan in endochrondral bones of the extremities. In Advances in Chitin and Chitosan. Eds: CJ Brine, PA Sandford, JP Zikakis. Elsevier Applied Science. London. 1992. 104 Ito F. Role of Chitosan as a supplementary food for osteoporosis. Gekkan Fudo Kemikaru, 1995;11(2):39-44. 105 Nakamura S, Yoshioka T, hamada S, Kimura I. Chitosan for enhancement of bioavailability of calcium. Jpn. Kokai Tokkyo Koho JP 07 194,316 [95 194,316] 01 Aug 1995. 106 Maekawa A, Wada M. Food Containing chitin or its derivatives for reduction of blood and urine uric acid. Jpn. Kokai Tokkyo Koho JP 03 280,852 [91 280,852], 11 Dec 1991. 107 Weisberg M, Gubner R. Compositions for oral administration comprising Chitosan and a pharmaceutically acceptable carrier. Antacid preparations for alleviating gastric hyperacidity. U.S. patent 3257275 108 Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E. Mechanism for the inhibition of fat digestion by Chitosan and for the synergistic effect of ascorbate. Biosci Biotech Biochem1995;59(5):786-90. 109 McCausland CW. Fat Binding Properties of Chitosan as Compared to Other Dietary Fibers. Private communication. 24 Jan1995. 110 Deuchi K, Kanauchi O, Imasato Y, Kobayashi E. Biosci Biotech Biochem. 1994:58,1613-6. 111 Ebihara K, Schneeman BO. Interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats. J Nutr 1989;119(8):1100-6. 112 Weil A, M.D. Natural Health Natural Medicine: Boston: Houghton Mifflin, 1990:182. 113 Chen Y-H, Riby Y, Srivastava P, Bartholomew J, Denison M, Bjeldanes L. Regualtion of CYP1A1 by indolo[3,2-b]carbazole in murine hepatoma cells. J Biol Chem 1995;270(38):22548-55. 114 Intestinal Absorption of metal ions and chelates. Ashmead HD, Graff DJ, Ashmead HH. Charles C Thomas, Springfield, IL 1985. 115 Nutrient Interactions. Bodwell CE, Erdman JW Jr. Marcel Dekker New York 1988. 116 Heleniak EP, Aston B. Prostaglandins, Brown Fat and Weight Loss. Medical Hypotheses 1989;28:13-33. 117 Connor WE, DeFrancesco CA, Connor SL. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann NY Acad Sci 1993;683:16-34. 118 Conte AA. A non-prescription alternative in weight reduction therapy. The Bariatrician Summer 1993:17-19. 119 McCarty MF. Inhibition of citrate lyase may aid aerobic endurance. Unpublished manuscript. 120 Bray GA. Weight homeostasis. Annual Rev Med 1991;42:205-216. 121 Dulloo AG, Miller DS. The thermogenic properties of Ephedrin/Methylxanthine mixtures: Human studies. Intl J Obesity 986;10:467-481. 122 Arai K, Kinumaki T, Fujita, T. Bulletin Tokai Regional Fisheries Res Lab. 1968;No. 56. 123 Bough WA. Private communication. 124 Freidrich EJ, Gehan, EA, Rall DP, Schmidt LH, Skipper HE. Cancer Chemotherapy Reports 1966;50(4):219-244. 125 A Drovanti, AA Bignamini, AL Rovati. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: A placebo-controlled double-blind investigation. Clinical Therapeutics 1980;3(4):260-272. 126 K Deuchi, O Kanauchi, M Shizukuishi, E Kobayashi. Continuous and massive intake of Chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet. Biosci. Biotech. Biochemistry. 1995;59(7):1211-6. 127 . BesChitin W in Chitin Wound Healing (video), Unitika Corporation, April 1992.
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June 21, 2005 05:25 PM
GPC (GlyceroPhosphoCholine): Versatile Life Support Nutrient
Parris Kidd, Ph.D.
GPC or GlyceroPhosphoCholine (pronounced gli-sero-fos-fo-ko-lean) is a nutrient with many different roles in human health. It reaches extremely high concentrations within our cells, and its abundance in mother's milk suggests it is crucial to life processes. Clinically, GPC has been most intensively researched for its brain benefits. Biologically, it has great importance for the skeletal "voluntary" muscles, the autonomic nervous system, kidneys, liver, and reproductive organs. GPC goes beyond being a brain nutrient; it is a nutrient for vitality and long life.
As a dietary supplement, GPC's brain benefits are unique. It boosts mental performance in healthy young people, as shown by three double-blind trials. In trials on middle aged subjects, GPC improved several physiologic measures of mental performance: reaction time, visual evoked potential, and EEG delta slow waves. In the elderly, GPC improves mental performance and provides noticeable revitalisation. In 11 human trials with 1,799 patients, memory, attention, and other cognitive measures improved. So did mood (including irritability and emotional lability), and patients often developed renewed interest in relatives and friends. GPC was well tolerated, and generated no bad drug interactions. A large trial on elderly subjects with memory challenges published in 2003 concluded GPC had significant benefits for these individuals.
GPC Supports Normal Brain Function
Circulatory deprivation or surgery can challenge healthy brain function. GPC can speed recovery and support improved quality of life. In four trials with GPC on 2,804 subjects who experienced difficulties under these circumstances, up to 95% showed good or excellent improvement. GPC consistently improved space-time orientation, degree of consciousness, language, motor capacity, and overall quality of life. The investigators concluded GPC offered marked benefits, with an excellent benefit-to-risk profile. Up to half of patients who survive bypass surgery experience problems with memory and other mental performance. A double-blind trial conducted with bypass survivors for six months determined that the GPC group had no remaining memory deterioration, while the placebo group failed to improve.
GPC Works Through Multiple Mechanisms
GPC supports human health through a variety of mechanisms:
1. It helps keep choline and acetylcholine available to the tissues. Choline is an essential nutrient and GPC appears to be the body's main choline reservoir. GPC in mother's milk represents the baby's main source of dietary choline. Acetylcholine (ACh) is an important substance employed extensively throughout the body. ACh is a major brain transmitter; the motor nerves use ACh to drive the skeletal ("voluntary") muscles; the autonomic nervous system uses it to pace all the organs. ACh is also central to mental and physical endurance, and mind-body coordination.
2. GPC is a major cell-level protectant, not as another antioxidant but in pivotal roles of osmotic pressure regulator and metabolic antitoxin. GPC for osmotic regulation can reach very high concentrations in the kidney, bladder, liver, brain, and other organs. As metabolic protectant, GPC shields proteins against urea buildup.
3. GPC is a major reservoir for cell membrane omega-3 phospholipids. These substances are the major building blocks for cell membranes. Enzymes couple GPC with the omega-3 fatty acid DHA, to make the phospholipid PC-DHA. This makes membranes especially fluid, enabling membrane proteins to perform with better efficiency. GPC produces PC-DHA in the skeletal muscles, wherein fluidity is essential for contraction. Muscles that function abnormally can show GPC deficiency.
4. GPC contributes to both male and female in reproduction. As spermatozoa mature, GPC is used to make PC-DHA that makes their membranes fluid to enable motility. With men, the lower their semen GPC the greater the likelihood of poor sperm motility and with it, infertility. Once semen is inserted into the female, an enzyme in uterine secretions breaks down the semen's GPC into substances that energize the sperm to achieve fertilization.
Dosing, Safety, Tolerability, Compatibility
Oral intake of GPC in the clinical trials was usually 1,200 milligrams (mg) per day, taken early in the day on an empty stomach. A reasonable dietary supplementation regimen is 1200 mg/day, taken in divided doses (AM and PM) between meals for 15-30 days, and thereafter 600 mg/day for maintenance. Symptomatic subjects can take 1200 mg/day until adequate improvement is achieved. Young, healthy subjects may experience benefit from daily intakes as low as 300 milligrams. GPC is very safe, being compatible with vitamins and nutrients and with pharmaceuticals. In clinical trial comparisons, GPC's benefits surpassed the nutrients acetylcarnitine and CDP-choline.
GPC is unmatched for its support of active living and healthy aging. In some 23 clinical trials GPC improved mental performance in all functional categories. GPC can revitalize the aging brain, facilitating growth hormone (GH) release and boosting nerve growth factor actions. GPC's ample presence in human mother's milk suggests it could be conditionally essential. By supporting mental integrity, mind-body integration, the autonomic system, and the body's other organs, GPC enhances the active lifestyle. GPC is remarkable nutritional support for optimal health at any age.
Parris M. Kidd, PhD is a cell biologist trained at the University of California, Berkeley and San Francisco. Since entering the dietary supplement field in 1983, he has published many in-depth reviews of integrative medicine in the journal Alternative Medicine Reviews, and is science columnist for totalhealth magazine. Dr. Kidd is internationally recognized for his accomplishments in dietary supplement product development, documentation and quality control.
Disclaimer: the above article is for informational purposes only and is not intended to diagnose or treat a particular illness. The reader is encouraged to seek the advice of a holistically competent licensed professional health care provider.
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Date:
June 21, 2005 05:10 PM
Take Your Vitamins: Reviewing Scientific Approaches to Selecting Daily Multiple Supplements
By Adina Licht, MS
Adina Licht, M.S. is a Nutritional Scientist and Science Writer who works as a Marketing Specialist for Source Naturals. She has a B.A. in Environmental Science from UC Berkeley, an M.S. in Nutrition and Food Science from San Jose State University, and training in Technical Communication from Cal State Hayward. Her work has appeared in publications such as Advances in Packaging and Development, Health Supplement Retailer and Delicious Living.
Americans Need More Nutrients
The U. S. population is drastically malnourished. According to the latest A. C. Nielsen survey, only 12% of Americans claim to eat the 5 recommended servings of fruits and vegetables each day (Warner, 2004). And approximately 1/3 of the calories that people do consume are from nutrient-poor foods such as alcohol and soda (Yang, 2004). This combination has led to a population that consumes too few nutrients, which according to an article in the Journal of the American Medical Association (Fletcher, 2002) puts people at risk for long-term health concerns. With Americans eating fewer healthy foods, taking a daily multiple is one way for people to increase their intake of nutrients. But the search for what defines a good multiple can be confusing, even to health care professionals.
The Confusing U.S. Government Standards
Scientists first recognized the need for vitamins in the early 1900s (Levenstein, 1993). But setting U. S. government standards for vitamins and minerals didn't start until healthy soldiers were needed to fight World War II. And when a committee of scientists was asked to determine the levels of nutrients needed to maintain good health they could only agree on "recommended allowances" to prevent deficiency with a wide margin of safety. In 1941, these allowances became the first Recommended Dietary Allowances (RDAs) for the nation (Levenstein, 1993). In 1997, the Food and Drug Administration (FDA) used latest RDAs to set the new Dietary Reference Intake (DRI) standards, which included Adequate Intakes (AIs) for when there was insufficient evidence to determine an RDA, and Upper Intake Levels (ULs) as the safe daily upper limit. To simplify the information, food labels express nutrient information as a percentage of the Daily Value (DV), which includes RDA values for a healthy adult who consumes 2000 calories per day (Whitney, 2002). However, these values do not include AIs or ULs and many individuals need different levels of nutrients than these.
Confusing Standards equals Confusing Recommendations
The RDAs and subsequent DRIs are the basis of the nutrient standards for at least 40 different nations and many professional health organizations. Currently, the American Dietetic Association (ADA) recommends that people who cannot reach the DRIs through diet take a multiple with nutrient levels that do not exceed the RDAs (JADA, 2001). And in 2002, the American Medical Association (AMA) published a paper that included a recommendation for all adults to take RDA levels of vitamin supplements in their Journal of the American Medical Association (Fletcher, 2002). Despite the benefits of having guidelines, most people only hear about the RDAs and DVs, which may be too low for preventing deficiencies while the ULs and AIs, which can be much more beneficial are rarely discussed. For example, the Daily Value of Vitamin E to prevent deficiency is 30 IU while the daily Upper Intake Limit is 1,467 IU. But, according to the ADA, as many as 75% of cardiologists recommend vitamin E to their patients to promote heart health, usually at a dosage of 400 IU (ADA, 2001; Meydani, 2004; & Whitney, 1998). And the Daily Value for Vitamin C is 60 mg while the daily Upper Intake Limit is 2000 mg, but in clinical studies it took 500 mg per day to help maintain healthy blood pressure (Whitney, 1998, & Hendler, 2001).
Alternative Recommendations
Lyle MacWilliam is a biochemist and former health advisor to the Canadian Ministry of Health, who decided to research, analyze and publish the Comparative Guide to Nutritional Supplements. In this book, the individually published recommendations from seven nutrition experts (Phyllis Balch, CNC, Dr. Michael Colgan, Ph.D., Dr. Earl Mindell, Ph.D., Dr. Michael Murray, N.D., Dr. Richard Passwater, Ph.D., Dr. Ray Strand, M.D., and Dr. Julian Whitaker, M.D.) were combined to create an ultimate blended standard of recommended median intakes for 39 nutrients to promote health. Those nutrients include vitamins, minerals, phytonutrients, and other supplements, that span 14 different health categories and are much closer to the Upper Intake Limit government standards. The guide also includes information about recommended forms, safety, purity and quality (MacWilliam, 2003). One of the most profound differences between MacWilliam?s compiled recommendations and the DRIs is the difference in the number of supplements: 39 vs. 26 respectively. The Comparative Guide standard includes additional nutrients, including many more antioxidants, based on decades of clinical research about their benefits. For example, the fat-soluble antioxidant Coenzyme Q10 that your body manufactures less of as you age is included. So is the fat and water-soluble antioxidant alpha lipoic acid that helps recycle other antioxidants such as vitamins C and E (Hendler, 2001).
Top Ranked Multiples for Optimal Health
In the latter half of MacWilliam's book he uses this ultimate blended standard to rank and compare 500 manufactured multiples. Of the five top-ranked multiples, only the Source Naturals multiples, Life Force and Élan Vitàl, are widely available at natural product stores and health outlets. And the new and improved Life Force formulation now rates higher than any of the products evaluated in the current edition of this guide (MacWilliam, 2004; & Mac-William, 2003). The ingredients that can be found in today's multiple supplements can vary greatly. But multiple choices don't have to lead to confusion. Health professionals, such as Lyle MacWilliam, understand the importance of remaining curious, evaluating the available research, and conferring with other scientists to determine the nutrients that support optimal health.
References
American Dietetic Association. 2001. Vitamin E: Disease Prevention for your Good Health. American Dietetic Association Website. Available at: Public/Other/index_nfs1001.cfm Fletcher, R. H., & Fairfield, K. M. 2002. Vitamins for Chronic Disease Prevention in Adults. JAMA. (23)287:3116-3129. Hendler, S. S., et al. 2001. PDR for Nutritional Supplements. Thomson Healthcare: Montvale. Pages 11-12, 17-21, 60-62, 103, 416-421, 486-498. JADA (Journal of the American Dietetic Association) 2001. Vitamin and mineral supplementation. J AM Diet Assoc.101: 115 Available at: Public/NutritionInformation/92_8343.cfm Levenstein, H. 1993. Paradox of Plenty: A Social History of Eating in Modern America. Oxford University Press: New York. Pages 13-15, 64-67. MacWilliam, L, et al. 2003. Comparative Guide to Nutritional Supplements. Northern Dimensions Publishing: Vernon. Pages 62-70. MacWilliam, L. 2004. Comparative Guide Individual Assessment of New Life Force Formulation. Warner, J. 2004. Few Follow '5 a Day' Fruit and Vegetable Rule. WebMD website. Available at: ent/Article/93/102158.htm Whitney, N. W., & Rolfes, S. R. (1998). Understanding Normal and Clinical Nutrition, 5th ed. Page 358. Whitney, E. N., & Rolfes, S. R. 2002. Understanding Nutrition. 9th ed. Wadsworth Thomson Learning: Belmont. Pages A, B, Y, 13-20, 55-56, 307, 331, 335-341, 401. Yang, S. 2004. Nearly one-third of the calories in the US diet come from junk food, researcher finds.
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Date:
June 14, 2005 10:52 AM
Nutritional Scorecard by Sylvia Whitefeather Energy Times, June 15, 2004
For over 50 years, the federal government has produced Recommended Daily Allowances (RDAs) as guidelines for vitamin and mineral intake. Then, in 1993, the Reference Daily Intakes (RDIs) superseded the RDAs. By applying this new designation, the government's guidelines are now supposed to represent the designated amounts that an average person should consume. With this in mind, and the fact that many experts think you should consume more than some of the RDIs, how does your nutritional scorecard add up? Answering a few nutritional questions can point you in the right direction.
Perfect Protein
Are you trying to lose weight? If you are, the latest thinking on weight loss opines that eating more protein may be the key to keeping your weight down. Two recent studies published in the Annals of Internal Medicine (5/18/04) found that people who ate a low-carbohydrate, high-protein diet lost more weight and had better cholesterol levels than dieters who ate fewer fatty foods. Both studies found that a low-carb diet can improve your triglycerides (blood fats) and boost your HDL, or good, cholesterol.
Eating protein satisfies both tummies and taste buds. Researchers have found that the amount of protein eaten in a meal determines not only how much food you eat but also how satisfied you feel after eating (J Nutr 2004 Apr; 134(4):974S-9S). And when you feel satisfied after eating less food you improve your odds of losing weight.
We need about 50 grams of protein a day to support the body's functions. The best sources of protein are eggs, meat, milk, protein shakes and yogurt.
Classy Carbohydrates
Does your energy level go up and down during the day? To get off the energy rollercoaster, cut down on carbohydrates, and make sure the carbs you do eat are complex.
Carbohydrates have been getting some unflattering press lately. Yes, if you want to lose weight, you may want to go on a strictly low-carb diet. But for those not concerned with weight, carbohydrates are the principle source of energy for the body.
What's more, even if you do restrict carbohydrates, you should still eat a tiny bit of them. Without some carbs in the diet your body cannot regulate protein or fat metabolism. According to Michael and Mary Eades, MD, authors of The 30-Day Low-Carb Diet Solution (Wiley), "Carbohydrates control insulin and insulin controls your metabolic health."
So, make your carbohydrates count. Indulge in complex carbohydrates: whole grains, fruits and vegetables. In those foods, carbs are accompanied by fiber and larger amounts of vitamins and phytonutrients. Other reliable sources of complex carbohydrates are whole wheat bread, brown rice and oatmeal.
Fabulous Fiber
Are you concerned about your heart health? Fiber from beans, oats, legumes, nuts, rice bran, fruits and vegetables helps stabilize blood sugar and reduce cholesterol. Pectins, found in apples, pears, prunes and plums, are a particularly useful form of water-soluble fiber.
Insoluble fiber, in cereals, wheat bran and vegetables, reduces the risk of colon-related problems. In addition to adding fiber to the diet, dried beans and soybeans have been shown to lower cholesterol, improve vascular health and kidney functioning, preserve bone mineral density and reduce menopausal discomforts (AJCN 1999 Sept; 70(3 suppl):464S-74S). Fiber also promotes good bowel health and encourages the growth of beneficial intestinal flora.
You need 25 to 40 grams of fiber daily. If you have cut back on your carbohydrates, be sure to take a reliable fiber supplement.
Fantastic Fats
Do you have problems focusing on mentally challenging tasks? If so, you should eat more fish and get more of the omega-3 fatty acids that fish and flax contain. Higher levels of this type of fat have been linked to better concentration while performing demanding intellectual work (Lipids 2004 Feb; 39(2):117-23).
Fats add flavor to food, making meals taste better. Monounsaturated fats like plain olive oil and canola are liquid at room temperature and are suitable for use in cooking at high temperatures. Researchers have found that a diet high in monounsaturated fat has the ability to decrease LDL (bad) cholesterol (J Nutr 2001; 131:1758-63). Other fats, such as extra virgin olive oil and flaxseed oil, are best used in dishes that don't need cooking, such as salads.
Although the RDI for fat is less than 30% of the total calorie intake, some researchers believe that if you eat healthy fat, eating too much is not a concern. Omega-3 fats are available in supplement form.
Wonderful Water
Do you suffer from dry skin? You may not be drinking enough water. This precious liquid is used by every cell of our bodies and makes up 60% to 75% of our body weight. Water is important for kidney function. Researchers in Italy found that drinking adequate amounts of water can help prevent the formation of kidney stones (Urol Int 2004; 72 Suppl 1:29-33).
Your activity level, environment and diet influence how much water you need daily. Try to drink at least eight cups of fluid a day from noncaffeinated, nonalcoholic sources.
Voluptuous Vitamins
Do you exercise frequently? If you do, you need more antioxidant vitamins like natural vitamin E and vitamin C as well as a healthy supply of carotenoids. A study at the School of Applied Medical Sciences and Sports Studies, University of Ulster, found that exercisers need more antioxidants. Otherwise, their exertion may release an excess number of free radicals (caustic molecules) in their bodies and do damage to the heart arteries and other internal organs.
Vitamins, in general, are defined as micronutrients that are necessary for life. They are necessary for the production of energy, a healthy immune system and hundreds of other functions in the body.
Vitamins aren't the only substances that produce big benefits in small quantities. Phytonutrients are chemicals in plants that have health-promoting properties. These nutrients are getting more and more attention from researchers who are keeping score on our nutritional requirements.
Mineral Crunch
Do your meals contain plenty of calcium? If not, you may need supplements to keep your bones strong and help keep your weight down. One study, presented at the Experimental Biology 2003 meeting in San Diego, found that young women who consumed more calcium had better luck controlling their weight. In this research, it didn't take much calcium to make a difference in waistlines. Consuming just one more serving daily (a cup of milk or a thumb-sized piece of cheese, each of which contain about 300 mg of calcium) made, on average, about a two-pound difference.
In addition, many experts recommend multimineral supplements (along with multivitamins) to promote better health. A recent study of people with immune problems, for instance, found that those kinds of supplements seem to help boost the immune system (AT News 2004 Feb 27; 398:4-5).
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Date:
June 13, 2005 07:43 PM
Celebrating Women: Age Is Just a Number by Carl Lowe Energy Times, March 10, 2004
As women age, their physical needs shift. The health challenges that face a woman in her thirties do not match those of a woman in her fifties.
At the same time, some basic health needs stay constant: At any age, every woman requires a wealth of vitamins, minerals and the other natural chemicals that fruits, vegetables and supplements supply. She also constantly needs families and friends to support her spiritual health.
As the internal workings of your body alter, your lifestyle must stay abreast of those adjustments. Peak health demands a finely tuned health program designed with your individual needs-and your stage of life-in mind.
Ages 30 to 45
When it comes to maintaining health, younger women might seem to have it easier than older women. If they exercise and stay in shape, they maintain more stamina than women 10 to 20 years their senior.
Unfortunately, many women in this age group mistakenly think they don't have to be as careful about their lifestyle habits and their eating habits as they will in later decades. But even if your health doesn't seem to suffer from poor eating choices or a sedentary lifestyle right away, your foundation for health in later life suffers if you don't care for yourself now.
By age 45 you should have established the good habits that will carry you successfully through the aging process. As an added bonus, good lifestyle habits pay immediate dividends. If you pay attention to your nutrients and get plenty of physical activity when younger, you'll feel more energetic and probably enjoy better emotional health.
Set Health Goals
According to Gayle Reichler, MS, RD, CDN, in her book Active Wellness (Avery/Penguin), good health at any age doesn't just come to you-you have to plan for it. In order to stick to good habits, she says, "living a healthy lifestyle needs to be satisfying." Reichler believes that you need to picture your health goals to achieve them: "Every successful endeavor first begins in the mind as an idea, a thought, a dream, a conviction." Good health at this age and in later years requires a concrete strategy and visualization of how your body can improve with a healthy lifestyle.
Your long-term health goals at this age should include an exercise program that will allow you to reach a physically fit old age with a lowered risk of disability. In addition, your short-term plans should encompass losing weight, staying optimistic, living life with more vim and vigor, increasing your capacity for exercise and lowering your stress.
As Reichler points out, "Your long-term goal and your ideal vision establish what you want to achieve....[You should do] something good...for yourself every day and every week that makes your life easier and more consistent with your goals."
Develop an Eating Plan
Today, the average American gains about two pounds annually. As a result, every year a greater portion of the US population is obese and overweight. By controlling your food intake earlier in life, you may be able to avoid this weight gain. In his book Prolonging Health (Hampton Roads), James Williams, OMD, recommends basic changes to your diet that can provide long-term support of your health:
Get Supplemental Help
If you're in your thirties or forties and you don't take at least a multivitamin, start taking one today! A large body of research shows that taking vitamin and mineral supplements over a long period of time significantly supports better health.
Calcium and vitamin D are two of the most important supplemental nutrients, helping to build stronger bones now that can withstand the bone-loss effects of aging.
Calcium can also help keep your weight down. One study of younger women found that for every extra 300 milligrams of calcium a day they consumed, they weighed about two pounds less (Experimental Biology 2003 meeting, San Diego).
In the same way, taking vitamin D supplements not only helps strengthen your bones, it can also lower your risk of multiple sclerosis (Neurology 1/13/04). In this study, which looked at the health records of more than 180,000 women for up to 20 years, taking D supplements dropped the chances of multiple sclerosis (although eating vitamin D-rich foods did not have the same benefit). And if you're thinking about having children at this age, a multivitamin is crucial for lowering your baby's risk of birth defects and other health problems. A study at the University of North Carolina at Chapel Hill found that women who take multivitamins during pregnancy lower their children's risk of nervous system cancer by up to 40% (Epidemiology 9/02).
" Our finding, combined with previous work on reducing several birth defects with vitamin supplementation and other childhood cancers, supports the recommendation that mothers' vitamin use before and during pregnancy may benefit their babies' health," says Andrew F. Olshan, MD, professor of epidemiology at the UNC School of Public Health. "We believe physicians and other health care providers should continue to educate women about these benefits and recommend appropriate dietary habits and daily dietary supplements."
In particular, Dr. Olshan feels that folic acid (one of the B vitamins), and vitamins C and A, are particularly important for lowering the risk of childhood cancers and birth defects.
Ages 45 to 55
When you reach this in-between age-the time when most women have moved past childbearing age but haven't usually fully moved into the post-menopausal stage-you enjoy a propitious opportunity to take stock of your health and plan for an even healthier future. One thing that may need adjustment is your sleep habits, as sleeplessness is a common problem for women in this age group. Even if you haven't been exercising or watching your diet until now, it's not too late to start. Making lifestyle changes at this age can still improve your chances for aging successfully.
For instance, it is at these ages that women should have their heart health checked. Research published in the journal Stroke (5/01) shows that having your cholesterol and blood pressure checked at this time more accurately shows your future chances of heart disease than having it checked at a later date after menopause, in your late fifties.
" The premenopausal risk factors may be a stronger predictor of carotid atherosclerosis [artery blockages] because they represent cumulative risk factor exposure during the premenopausal years, whereas the risk factors...during the early postmenopausal years have a shorter time for influence," says Karen A. Matthews, PhD, a professor at the University of Pittsburgh Medical Center. In other words, Dr. Matthews' research shows that if you have high blood pressure and high cholesterol before menopause, you are at serious risk for a stroke or heart attack soon after menopause: These are important reasons that you need to start improving your health habits immediately.
Increase in Heart Disease
Before menopause, a woman's hormones and other physiological characteristics usually hold down her chance of heart disease. After menopause, when hormones and other bodily changes occur, the risk of heart attacks and stroke in women rises significantly. (Heart disease is the leading killer of women.) At least part of this increased risk is linked to the postmenopausal decrease in estrogen production.
Dr. Matthews studied about 370 women in their late forties, measuring their weight, their BMI (body mass index, an indication of body fat compared to height), blood pressure, cholesterol and blood sugar. Ten years later, after the women had entered menopause, she and her fellow scientists used ultrasound to measure blockages in these women's neck arteries (a sign of heart disease).
The researchers found that indications of potential heart problems (such as high blood pressure, high cholesterol and being overweight) when women were in their forties did indeed forecast future difficulties.
" Women who had elevated cholesterol, higher blood pressures and increased body weight before menopause had increased blood vessel thickening and atherosclerotic plaque formation in the neck arteries after menopause. Such changes in the carotid arteries are associated with an increased heart attack and stroke risk," says Dr. Matthews.
Heart Health Factors
The four main lifestyle factors you should adjust at this age to support better heart function are diet, stress, exercise and weight. According to Dr. James Williams, "[M]ore than any other cause, dietary factors are the most critical factor in cardiovascular disease." He recommends eliminating "dietary saturated fatty acids as found in flame-broiled and fried meats." He also urges women to eat more fish and poultry, consume organic fruits and vegetables and cut back on refined sugar.
Stress becomes an ever more important heart disease factor at this age as estrogen begins to drop.
" Our study [in the lab] indicates that stress affects estrogen levels and can lead to the development of heart disease-even before menopause," says Jay Kaplan, PhD, of the Wake Forest University Baptist Medical Center (The Green Journal 3/02).
Dr. Kaplan's research shows that stress in women ages 45 to 55 may reduce estrogen earlier in life and make women more susceptible to the arterial blockages that lead to heart disease. "We know from [lab] studies that stress can lower estrogen levels to the point that health is affected," he says.
Stress can also hurt bone health: In a study of 66 women with normal-length menstrual periods, estrogen levels were low enough in half of the women to cause bone loss, making the women susceptible to osteoporosis.
Exercise and Weight
Although exercise used to be considered to be mainly a young woman's activity, the thrust of recent research suggests that physical activity actually becomes more important to health as you get older.
A 17-year study of about 10,000 Americans found that exercising and keeping your weight down is probably the most important thing you can do to lower your risk of heart disease as you enter your forties and fifties (Am J Prev Med 11/03).
Of the people who took part in this study, more than 1,500 people died of heart disease. Those who performed the most exercise were thinner and had a 50% chance less of dying of heart disease than overweight nonexercisers.
" The fact is that those who both exercised more and ate more nevertheless had low cardiovascular mortality," says Jing Fang, MD, a researcher at the Albert Einstein College of Medicine in the Bronx, New York.
An added benefit of exercise: If you burn up calories exercising, you can eat more and not have to worry as much about being overweight.
Supplements and Diet
If you're a woman at midlife, a multivitamin and mineral is still good nutritional insurance. Eating plenty of fruits and vegetables are also important for getting enough phytochemicals, the health substances in plants that convey a wealth of health benefits.
As you enter this age group, your immune system gradually slows down. To help support immune function, eating produce rich in antioxidant nutrients, and supplementing with antioxidants like vitamins C and E as well as carotenoids, can be especially important. For example, a study of people with ulcers found that people with less vitamin C in their stomachs are more likely to be infected with Helicobacter pylori, the bacteria that can cause peptic ulcers and is linked to stomach cancer (J Amer Coll Nutr 8/1/03).
This research, which looked at the health of about 7,000 people, found that vitamin C probably helps the immune system fend off this bacterial infection.
" Current public health recommendations for Americans are to eat five or more servings of fresh fruits and vegetables a day to help prevent heart disease, cancer and other chronic diseases," says Joel A. Simon, MD, MPH, professor of medicine at the University of California at San Francisco.
Calcium and Bones
At midlife, calcium continues to be a vital mineral for supporting bone health.
According to Gameil T. Fouad, PhD, "It has been routinely shown that a woman's calcium status and level of physical activity (specifically, the degree to which she participates in weight-bearing exercise) are positively associated with bone mineral density. It is less well appreciated that this is a process which takes place over the course of a lifetime."
Dr. Fouad adds that calcium works in concert with other vitamins and minerals to keep bones healthy: "Research in the United Kingdom involving nearly 1,000 premenopausal women over age 40 illustrates those women with the highest bone density tended to have the highest intake of calcium. Surprisingly, this study also demonstrated that calcium does not act alone: those women with the best bone health also had the highest intakes of zinc, magnesium and potassium."
Dr. Fouad stresses that supplements should go together with a lifestyle that includes enough sleep and exercise to help the body stay in top shape.
" As a general guideline," he says, "a woman concerned with her mineral intake should take concrete steps to make sure she is getting adequate rest, is eating a well-balanced diet focused on fresh fruits, vegetables and lean protein as well as getting adequate exercise....A multi-mineral containing bio-available forms of zinc, magnesium, copper and selenium is probably a safe addition to anyone's routine. Taking these proactive steps dramatically reduces the chances that deficiencies will arise."
Ages 55 and Beyond
Entering the post-menopausal phase of life can present challenging opportunities for a new perspective on life and health. While some signs of aging are inevitable, experts who have looked at how the human body changes with age are now convinced that healthy lifestyle habits can improve how well you can think, move and enjoy life well past age 55.
As Dr. Williams notes, "In your fifties, the force of aging is undeniably present: Your body shape changes and organ function declines, both men and women have a tendency to gain weight....Heart disease becomes more common, energy and endurance are considerably reduced and your memory begins to slip."
But Dr. Williams also points out that you don't have to age as rapidly as other people do. He believes you should employ a "natural longevity program...[that starts] to reverse the course of aging as early as possible."
One key to staying vital as you age is your outlook on life, an aspect of life that's greatly enhanced by strong social ties.
Avoiding the Aging Slowdown The latest research shows that one of the most crucial ways to slow the effects of aging is to exercise and keep your weight down. It won't necessarily be easy, though. The change in hormonal balance at this age makes the body more prone to extra pounds (Society for Neuroscience Meeting, 11/12/03).
" In women, it has been demonstrated that major weight increases often occur during menopause, the time in a woman's life in which cyclic ovarian function ends and the ovarian hormones estrogen and progesterone decline," says Judy Cameron, PhD, a scientist in the divisions of reproductive sciences and neuroscience at the Oregon Health & Science University.
In Dr. Cameron's lab trials, she has found that the decrease in estrogen after menopause "resulted in a 67% jump in food intake and a 5% jump in weight in a matter of weeks."
In other words, the hormonal changes you undergo as enter your late fifties causes your appetite to grow as well as your waistline: Developments that increase your chances of heart disease, cancer, diabetes, stroke and joint problems.
Vigilance against this weight gain is necessary to save your health: Start walking and exercising. Research on exercise in people aged 58 to 78 found that getting off the couch for a walk or other physical activity not only helps control weight but also helps sharpen your thinking and helps you become more decisive (Proceedings of the National Academy of Sciences, 2/16-20/04, online edition). This recent study, done at the University of Illinois at Urbana-Champaign, found that performing aerobic exercise improved mental functioning by 11% (on a computer test).
" We continue to find a number of cognitive benefits in the aerobic group," says Arthur F. Kramer, PhD, a professor of psychology at the Beckman Institute for Advanced Science and Technology at Illinois. "The brain circuits that underlie our ability to think-in this case to attend selectively to information in the environment-can change in a way that is conducive to better performance on tasks as a result of fitness." In simple terms, that means that walking at least 45 minutes a day boosts brain power as well as protecting your heart.
An Herb for Menopause
The physical changes that accompan> y menopause can be uncomfortable. But traditional herbal help is available: Black cohosh (Cimicifuga racemosa), an herb used for eons by aging women, has been shown in recent studies to be both safe and effective (Menopause 6/15/03).
" This [research] should reassure health professionals that they can safely recommend black cohosh to their menopausal patients who cannot or choose not to take HRT [hormone replacement therapy]," says researcher Tieraona Low Dog, MD, Clinical Assistant Professor at the University of New Mexico Department of Family and Community Medicine.
While HRT has been used to help women cope with menopause, a flurry of studies in the past few years have shown that HRT increases the risk of heart disease and cancer. Instead, black cohosh, which alleviates such menopausal discomforts as hot flashes, has been shown to be much safer.
Keeping Track of Crucial Vitamins
While continuing to take multivitamins and minerals at this age is important, some experts believe that as we grow older, vitamin D supplementation, as well as taking antioxidant nutrients, is particularly vital. Arthritis is a common affliction of aging, and rheumatoid arthritis (RA) is one particularly destructive form of this joint problem. But taking vitamin D can significantly lower your risk of this condition.
When scientists analyzed the diets of 30,000 middle-aged women in Iowa over 11 years, they found that women who consumed vitamin D supplements were 34% less likely to suffer RA (Arth Rheu 1/03).
Other vitamins are equally important to an older woman's well-being. For example, vitamins C and natural E have been found to lower the risk of stroke in those over the age of 55 (Neurology 11/11/03). In this study, smokers who consumed the most vitamin C and natural vitamin E were 70% were much less likely to suffer strokes than smokers whose diets were missing out on these vitamins.
Rich sources of vitamin C in food include oranges and other citrus fruits, strawberries, red and green peppers, broccoli and brussels sprouts. Sources of vitamin E include vegetable oils such as sunflower seed, cottonseed, safflower, palm and wheat germ oils, margarine and nuts.
Saving Your Sight
After age 55, your eyes are particularly vulnerable. Eight million Americans of this age are at risk for age-related macular degeneration (AMD), a condition that destroys structures in the back of the eye necessary for vision (Arch Ophthal 11/03). But you can drop your risk of AMD by taking supplements of antioxidant vitamins and zinc, according to researchers at Johns Hopkins' Wilmer Eye Institute.
Their research shows that a dietary supplement of vitamins C, natural vitamin E and beta carotene, along with zinc, lowers the chances of progressing to advanced AMD in certain at-risk people by about 25%. Daily supplements also reduced the risk of vision loss by about 19%.
The carotenoids lutein and zeaxanthin also help protect aging eyes. When scientists compared healthy eyes with eyes suffering from AMD, they found that AMD eyes contained lower levels of these vital nutrients (Ophthalmology 2003; 109:1780). Furthermore, they found that levels of these chemicals generally decline as you grow older.
Healthy at All Ages
When it comes to designing a healthy lifestyle, general rules like these can be followed, but you should individualize your plan to fit your needs. No matter which type of exercises you pick out or what healthy foods you choose, look for a strategy and a plan you can stick to. If you think a selection of foods are good for you but you absolutely hate their taste, chances are you won't be able to stick to a diet that includes them.
The same goes for exercise: Pick out activities that you enjoy and that you can perform consistently. That increases your chance of sticking to an exercise program.
Staying healthy is enjoyable and it helps you get more out of life every day, no matter what stage of life you're in.
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Date:
June 02, 2005 01:21 PM
Committed to providing you with the most advanced and effective forms of nutrition, Source Naturals now offers LIQUID CALCIUM 1200 WITH MAGNESIUM. More than a convenient and great tasting way to ensure your daily intake of calcium, Source Naturals LIQUID CALCIUM 1200 WITH MAGNESIUM also supplies 100% of the magnesium and vitamin D your body needs to utilize calcium—enabling this essential mineral to maintain proper bone and muscle function. And all the minerals in Source Naturals LIQUID CALCIUM 1200 WITH MAGNESIUM are highly soluble and more easily assimilated because they’re in the lactate form, which is nondairy yet highly bio-available. Source Naturals LIQUID CALCIUM 1200 WITH MAGNESIUM is ideal for those who dislike taking large tablets or who have trouble digesting them. One of Source Naturals’ most popular formulas, this unique combination of high-quality nutrition and convenience comes without the chalky taste of many other liquid mineral supplements. Great tasting creamy orange natural flavor.
Calcium is well-known for its role in building strong bones and teeth, but this essential mineral has many other vital functions, including regulating the transmission of nerve impulses throughout the body and the passage of nutrients into and wastes out of cells. Magnesium, too, has numerous metabolic functions in the body. More than 300 different enzymes depend on magnesium, including ones that help convert dietary sugars and fats into energy. Magnesium is needed to synthesize DNA, RNA, and the brain proteins that store and retrieve memories. What’s more, your body uses magnesium to make sure calcium gets into your bones, not your soft tissues.
Calcium and Magnesium Work Together
Even with sufficient calcium in the diet, bone health still depends on adequate levels of magnesium. That’s because vitamin D needs magnesium to synthesize the calcium-binding proteins that transport calcium from the intestine into the blood. Magnesium also controls secretion of thyrocalcitonin, the hormone that directs calcium into bones. And adequate magnesium helps prevent over-secretion of parathyroid hormone that dissolves calcium from bones.
Cardiovascular Health
Taking magnesium with calcium is not only a wise strategy to ensure a healthy skeletal system, it’s also heart smart. Both calcium and magnesium support proper blood coagulation. Calcium affects muscle contraction while magnesium affects muscle relaxation including the heart muscle. The micromuscles surrounding arteries require sufficient magnesium to keep from excessive constriction or spasm. And with potassium, magnesium regulates the heart’s electrical activity. Epidemiological studies worldwide show a direct relationship between heart health and levels of magnesium and calcium in drinking water. A 30-year study of more than 7,000 men found a significant association between higher daily magnesium intake and cardiovascular health. Magnesium supplementation is important because modern diets are low in this vital mineral, and many factors increase magnesium loss from the body. Alcohol is the most notorious depleter of magnesium. Dietary imbalances such as high intakes of fat and/or calcium can intensify magnesium inadequacy. Stress hormones also deplete calcium from bones.
Calcium without the Cow
Source Naturals LIQUID CALCIUM 1200 WITHMAGNESIUM’s highly soluble mineral lactates (unrelated to lactose) offer excellent bio-availability for maximal absorption. This great tasting nondairy mineral supplement takes advantage of the latest knowledge in nutritional science to optimize the many vital functions of calcium and magnesium in the body. It is available in 16 oz and 32 oz sizes.
References
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Date:
May 13, 2005 08:38 AM
by Richard Conant, L.Ac, C.N.
The health benefits of vegetables were known historically, long before researchers began seeing a connection between vegetable consumption and cancer prevention. Over the last twenty years, evidence concerning this connection has steadily accumulated. The latest and most promising findings reveal that specific vegetable constituents—"phytochemicals" to use current scientific parlance— enhance the body's defenses against cancer.
This article will focus on one phytochemical in particular, a sulfur-containing compound called "sulforaphane." Found in Cruciferous vegetables such as broccoli, sulforaphane may prove to be one of our most powerful cancer prevention allies. Recent studies have shown that sulforaphane stimulates, or "induces," "Phase two enzymes." These enzymes are an integral part of the body's elaborate detoxification system that renders carcinogens inactive. This detoxification system turns carcinogens and other toxic substances into harmless molecules that are excreted from the body.
We need not fear carcinogens—the body is equipped to deal with them.
These findings, coupled with an appreciation of the body's ability to defend itself against carcinogens, have the potential to dramatically change the way we look at cancer and substances in the environment that "cause" cancer. We need to minimize unnecessary exposure to carcinogens, and the staggering quantity of hazardous chemicals in the environment remains an urgent health concern, for cancer and many other health problems. But, knowing the body is equipped with the means to defend itself against toxins, we do not need to fear carcinogens as perhaps we have in the past.
The natural world is full of carcinogens.
What's more, even if you eat 100 percent organic food and live in a environment free of toxic man-made chemicals, you are still being exposed to carcinogens every day of your life. Food is the primary route of this exposure. Plants, for their own defense, produce over 99% of all the pesticides in agricultural products.1 Almost all foods—in their natural state—contain tiny amounts of naturally-occurring, potentially carcinogenic chemicals.
The point is not to trivialize the concern over environmental toxins. The point is that the natural world is full of toxins that are not man-made. These substances have been around since before we appeared, which is why we have evolved with a highly efficient system for neutralizing them before they can damage our cells and initiate the complex process that produces cancer.
Broccoli sprouts are a concentrated source of cancer-fighting sulforaphane.
We cannot avoid carcinogens. What we can do is support our internal detoxification system. Sulforaphane is a powerful tool in this effort. We can start by following the often-repeated advice to eat a variety of vegetables every day, and include broccoli in our menu.
There is an even richer source of sulforaphane than broccoli itself. In September 1997, a group of scientists at the Johns Hopkins University School of Medicine made a breakthrough discovery— broccoli sprouts contain ten to one hundred times more sulforaphane than mature broccoli.2 Vegetable sprouts are generally regarded as exceptionally healthy foods. Broccoli sprouts now look like a shining star, especially when it comes to cancer prevention.
For those lacking the time or inclination to keep a fresh supply of broccoli sprouts on hand, broccoli spouts have been processed into an extract that is even more concentrated in sulforaphane. More on this later.
What have researchers learned about broccoli consumption and cancer rates?
More than 200 epidemiological studies—studies which track groups of people over time to uncover realtionships between variables such as diet and the incidence of disease—have invesitgated the connections between vegetable consumption and various forms of cancer.1 It should be understood that findings from epidemiological research are generally not regarded as conclusive; these studies are not controlled, and often use data gleaned from questionnaires, which are an imprecise method of gathering information. (In the case of diet questionnaires, for example, the study subjects may or may not record their food intakes with 100 percent accuracy.)
Epidemiological studies look for trends. To be credible, these trends need to show up consistently, in different population groups. Findings from the vegetable intake/cancer studies easily meet these criteria; the number of studies is large and the trend is consistent—vegetable consumption is strongly associated with a lower risk of developing cancer.
What about broccoli in particular? A paper published in the September 1996 issue of Cancer Epidemiology, Biomarkers & Prevention analyzes epidemiological data gathered from 94 studies concerning the cancer preventive effect of brassica vegetables.3 (The Brassica genus, part of the Cruciferae family, includes broccoli, cabbage, kale, cauliflower and brussels sprouts.) The data suggest that broccoli consumption reduces the risk of some of the most feared forms of cancer, including stomach and lung cancer.
Now, to put these data into a balanced perspective, the researchers point out that in most of the studies reviewed, brassica vegetable consumption was reported as part of the total vegetable intake. "In hardly any epidemiological studies was the effect of brassica vegetables separated from the effect of total vegetables or other vegetables by adjusting for consumption of these variables. Therefore, it is difficult to sort out whether the observed observation was attributable to brassica vegetables, to vegetables as a whole, or to other vegetables," they noted.
This uncertainty is a good example of why epidemiological studies alone do not give us open and shut conclusions. But the paper also adds that the apparent anti-cancer effect of brassica vegetables agrees with "the results of experimental studies in which brassica vegetables reduced mammary tumor incidence, hepatic tumor size, numbers of tumors per liver, tumor frequency, and the number of pulmonary metastases when given to rodents before or after a carcinogen insult."3
When you put together a plausible trend from epidemiological research with results of experimental studies that agree with the trend, and then add additional research that reveals the underlying mechanism for these observations, a clear picture begins to take shape. And, indeed, we now have a fairly good idea as to just how brassica vegetables, especially broccoli, help prevent cancer.
How sulforaphane helps prevent cancer from developing.
To see how sulforaphane works, let's look at a brief overview of the body's detoxification system.
The detoxification of carcinogens and other toxic substances takes place in the liver, and involves two distinct enzyme-driven processes or "phases". Phase one enzymes neutralize toxins by various routes. Some of these convert toxins into substances that are immediately eliminated. However, other Phase one steps convert toxins into intermediate products which are carcinogenic themselves, and require further treatment before they can be excreted. Phase two enzymes do this vital job. Phase two enzymes deactivate these carcinogenic metabolites of Phase one, and the final breakdown product is then eliminated once and for all. (For an excellent review of this subject, see Encyclopedia of Natural Medicine, by Drs. Michael Murray and Joseph Pizzorno.4)
Phase two is critical. If Phase one is in good working order, but Phase two is not, the potential threat from carcinogens increases. It is vitally important to keep Phase two operating well. This is where sulforaphane plays its cancer preventive role. Sulforaphane is a powerful inducer of Phase two enzymes.5,6
Broccoli sprouts-the ideal source of sulforaphane
Sulforaphane is one among a group of phytochemicals called "isothiocyanates." (These occur in brassica vegetables largely as "glucosinolates," which are precursors for isothiocyanates2,12 When the plant is crushed, glucosinolates are converted to isothiocyanates.) Sulforaphane induces Phase two enzymes exclusively, leaving Phase one enzymes alone. This means it helps reduce the load of carcinogenic Phase one intermediates without adding to the load by stimulating Phase one.8,9
As reported by the Johns Hopkins University research group, broccoli sprouts are an "exceptionally" rich source of sulforaphane (in the form of "glucoraphanin, sulforaphane's glucosinolate precursor). And broccoli sprouts have another advantage over mature broccoli. They contain almost no indole glucosinolates, phytochemicals present in mature broccoli that "can enhance tumorogenesis."2
Broccoli sprouts as an extract, now available as a dietary supplement, takes the concentration of sulforaphane to the next level. This recently developed nutraceutical product contains a potent 20 to 1 extract of three-day old fresh broccoli sprouts.
One 125 mg capsule supplies the same amount of sulforaphane as 125 grams, or about 5 ounces, of mature broccoli. Taking just one capsule a day is like eating two pounds of broccoli per week, which equals the intake of cruciferous vegetables believed necessary to obtain their health benefits.
References
1. Steinmetz, K.A. Potter, J.D. Vegetables, fruit, and cancer prevention: A review. J Am Diet Assoc. 1996;96:1027-1039.
2. Fahey, J.W., Zhang, Y., Talalay, P. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. 1997; 94:10367-10372.
3. Verhoeven, D.T.H., et. al. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiology, Biomarkers & Prevention 1996;5:733-48.
4. Murray, M. Pizzorno, J. Encyclopedia of Natural Medicine. Rocklin, CA: Prima Publishing;1998:110-120.
5. Zhang, Y. Talalay, P, Cho, C., Posner, G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure. Proc. Natl. Acad. Sci. 1992;89:2399-2403.
6. Gerhäuser, C. et. al. Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes. Cancer Research 1997;57:272-78.
7. McDanell, R., McLean, A.E.M., Hanley, A.B., Heaney, R.K., Fenwick, G.R. Chemical and biological properties of indole glucosinolates (glucobrassicins): A review. Fd. Chem. Toxic. 1988;26(1):59-70.
8. Talalay, P. Mechanisms of induction of enzymes that protect against chemical carcinogenesis. in Advances in Enzyme Regulation, Vol. 28, Weber, G., Ed., 1989: Pergamon Press.
9. Prochaska, H.J. Santamaria, A.B., Talalay, P. Rapid detection of enzymes that protect against carcinogens. Proc. Natl. Acad. Sci. 1992;89:2394-98.
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Fish oil contains the omega-3 fatty acids that play a crucial role in performance and health throughout life. The omega-3 nutrients, containing EPA and DHA, are most frequently linked with heart health although they accomplish far much than that.
It has been consistently revealed by epidemiological research that individuals with a high dietary intake of antioxidant vitamins have a risk that is lower-than-average of cardiovascular disease. This evidence seems to be especially consistent for vitamin E. Additionally, many clinical studies show that magnesium supplementation is of significant benefit in the treatment of cardiac arrhythmias and in reversing the depletion of 
Comments by Craig Gerbore, CEO of Madhava: 
Who is the author, Rami Nagel? 
